FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public
Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

GRISWOLD JAMES B 		2. Issuer Name and Ticker or Trading Symbol

KEITHLEY INSTRUMENTS INC [ KEI ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

KEITHLEY INSTRUMENTS, INC., 28775 AURORA ROAD 		3. Date of Earliest Transaction (MM/DD/YYYY)

5/13/2010
(Street)

SOLON, OH 44139
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Shares   5/13/2010     A    1417   A $0.00   35164   D    
Common Shares                  20000   D   (1)  

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Common Stock Option   $36.85                    8/18/2001   2/17/2011   Common Stk   10000     10000   D    
Common Stock Option   $19.23                    8/17/2002   2/16/2012   Common Stk   10000     10000   D    
Common Stock Option   $23.13                    8/15/2004   2/14/2014   Common Stk   10000     10000   D    
Common Stock Option   $16.67                    5/13/2005   2/12/2015   Common Stk   10000     10000   D    
Phantom Stock Units     (2)                    (3)   (3) Common Stock   59045.17   (2)   59045.17   (2) D    

Explanation of Responses:
( 1)  Roth IRA
( 2)  Phantom shares were acquired on various dates (beginning 09/19/1995) with prices ranging from $2.469 to $64.00.
( 3)  The phantom stock units were accrued under the Keithley Instruments, Inc. Deferred Stock Plan and are to be settled in ten annual installments in common stock or cash upon the retirement from the Board of the reporting person; retirement date is not yet known.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
GRISWOLD JAMES B
KEITHLEY INSTRUMENTS, INC.
28775 AURORA ROAD
SOLON, OH 44139 		X



Signatures
Mark J. Plush, Attorney-in Fact 5/14/2010
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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