biOasis Presents Results From It's BT2111 Program at International
Cancer Research Conference
biOasis and collaborators from Alexandria University, Egypt;
Texas Tech University HSC, Amarillo, Texas and; the West Virginia
University HSC, School of Pharmacy, Morgantown, WV; Presents
Progress in Developing a Novel Therapy to Treat Brain Metastases of
Breast Cancer
VANCOUVER, BRITISH COLUMBIA--(Marketwired - Apr 3, 2014) -
biOasis Technologies Inc. (TSX-VENTURE:BTI)(OTCQX:BIOAF), a
pioneering biopharmaceutical company focused on overcoming the
limitations of therapeutic drug delivery across the blood-brain
barrier, will present results from it's BT2111 program at the 105th
Annual Meeting of the American Academy of Cancer Research (AACR)
being held April 5th to 9th, 2014, in San Diego, California.
Details of the presentations are as follows:
Presentation 642. Transcend, a protein vector for
brain delivery, allows trastuzumab to reach the brain at effective
concentration after incorporation to form BT2111 |
|
Session: Immune Mechanisms Invoked by Radiation, Chemotherapy, or
Targeted Therapy |
Apr 6, 1:00 - 5:00 PM |
|
Presentation 2653. Anti-cancer antibody
trastuzumab-melanotransferrin conjugate (BT2111) for the treatment
of metastatic HER2+ breast cancer tumors in the brain: An in vivo
study |
|
Session: New Antibodies and Antibody Drug Conjugates |
Apr 7, 1:00 - 5:00 PM |
|
Presentation 2905. The activity of a new class of
biologics: trastuzumab conjugates designed to treat brain
metastases of HER2+ breast cancers |
|
Session: Prophylactic and Therapeutic Immune-based Therapies |
Apr 7, 1:00 - 5:00 PM |
About BT2111
BT2111 is a hybrid drug candidate consisting of a biOasis'
Transcend delivery vector linked to trastuzumab, a humanized
monoclonal antibody used clinically in the treatment of HER2+
breast cancer. It is reported that up to 30% of HER2+ breast cancer
patients develop brain metastasis for which therapeutic options are
limited. Because of its ability to cross the blood-brain barrier,
biOasis is developing BT2111 as a potential treatment for brain
metastases of HER2+ breast cancer.
About the 105th AACR Annual Meeting
The 105th Annual Meeting of the American Association for Cancer
Research, the premier annual cancer research event where the latest
and most exciting basic, translational, and clinical discoveries
are presented, will be held April 5-9, 2014, in San Diego,
California. The theme for this year's meeting, "Harnessing
Breakthroughs - Targeting Cures," reflects the fact that the
translation of basic science into clinical advances for the benefit
of cancer patients is occurring at an increasing pace and more
seamlessly than ever before. Approximately 18,000 researchers,
patient advocates, and other professionals in the cancer field from
around the world are scheduled to be in attendance. The 2014 AACR
meeting provides a unique opportunity for members of the worldwide
cancer research community to learn about cutting-edge advances,
obtain feedback on their own research, and make connections that
will foster future collaborations. For more information on the
105th AACR Annual Meeting please visit:
http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx
About Transcend
Transcend offers the creation of a new class of drugs that can
cross the blood-brain barrier to address unmet medical needs in the
treatment of brain metastatic cancer and other brain disorders,
such as neurodegeneration and metabolic disease. The blood-brain
barrier represents the single greatest challenge in treating
diseases and other disorders within the brain. Diseases such as
cancer are readily treated in many areas of the body, but drugs
designed to treat cancer simply cannot penetrate the blood- brain
barrier.
Over the past five years, biOasis has developed a unique and
novel blood-brain barrier vector called Transcend. Trials in animal
models have shown that Transcend can deliver Herceptin®, a
chemotherapeutic used to treat HER2-positive breast cancer, in
sufficient quantity to the brain to significantly reduce the number
of HER2-positive metastatic brain tumors. Further, after only four
treatments, the remaining tumor masses were reduced in size by an
average of 58%.
Also in animal models, the company has demonstrated that the
Transcend vector could deliver a 4-to-8- fold increase of a variety
of different therapeutic biologics across the blood-brain-tumor
barrier versus the compounds on their own.
The ability to more effectively permeate both the blood-brain
and the blood-tumor barrier opens the door for the creation of new
drugs designed to treat a wide variety of neurological diseases and
disorders. Additionally, Transcend offers the potential to take
existing clinically approved drugs that are near their end of
patent life and extend them.
About biOasis
biOasis Technologies Inc. is a biopharmaceutical company
headquartered in Richmond, BC, Canada. Based on Transcend, biOasis'
proprietary brain delivery platform, the company is focused on
creating new drugs that can cross the blood-brain barrier to
address unmet medical needs in the treatment of brain disorders
such as neurodegeneration, metastatic cancer and metabolic
diseases. biOasis trades on the OTCQX under the symbol "BIOAF" and
on the TSX Venture Exchange under the symbol "BTI". For more
information about the company please visit www.bioasis.ca.
Forward-Looking Statements
Certain statements in this press release contain forward-looking
statements within the meaning of the Private Securities Litigation
Reform Act of 1995 or forward-looking information under applicable
Canadian securities legislation that may not be based on historical
fact, including without limitation statements containing the words
"believe", "may", "plan", "will", "estimate", "continue",
"anticipate", "intend", "expect" and similar expressions. Such
forward-looking statements or information involve known and unknown
risks, uncertainties and other factors that may cause our actual
results, events or developments, or industry results, to be
materially different from any future results, events or
developments express or implied by such forward-looking statements
or information. Such factors include, among others, our stage of
development, lack of any product revenues, additional capital
requirements, risk associated with the completion of clinical
trials and obtaining regulatory approval to market our products,
the ability to protect our intellectual property, dependence on
collaborative partners and the prospects for negotiating additional
corporate collaborations or licensing arrangements and their
timing. Specifically, certain risks and uncertainties that could
cause such actual events or results expressed or implied by such
forward- looking statements and information to differ materially
from any future events or results expressed or implied by such
statements and information include, but are not limited to, the
risks and uncertainties that: products we develop may not succeed
in preclinical or clinical trials, or future products in our
targeted corporate objectives; our future operating results are
uncertain and likely to fluctuate; we may not be able to raise
additional capital; we may not be successful in establishing
additional corporate collaborations or licensing arrangements; we
may not be able to establish marketing and the costs of launching
our products may be greater than anticipated; we have no experience
in commercial manufacturing; we may face unknown risks related to
intellectual property matters; we face increased competition from
pharmaceutical and biotechnology companies; and other factors as
described in detail in our filings with the Canadian securities
regulatory authorities at www.sedar.com. Given these risks and
uncertainties, you are cautioned not to place undue reliance on
such forward-looking statements and information, which are
qualified in their entirety by this cautionary statement. All
forward-looking statements and information made herein are based on
our current expectations and we undertake no obligation to revise
or update such forward- looking statements and information to
reflect subsequent events or circumstances, except as required by
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On Behalf of the Board of Directors,
Rob Hutchison, Chairman & CEO
"Neither the TSX
Venture Exchange nor its Regulation Services Provider (as that term
is defined in the policies of the TSX Venture Exchange) accepts
responsibility for the adequacy or accuracy of this release"
biOasis Technologies Inc.Rob HutchisonChairman &
CEO778-383-3280rob@bioasis.cawww.bioasis.caInvestor Relations
Contact:Liolios Group, Inc.Ron BothSenior Managing
Director949-574-3860BTI@liolios.com
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