Protherics PLC


               Notification of Major Interest in Shares



London, UK; Brentwood, TN, US; 28 October 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that the
following notification of interest in the ordinary share capital of the
Company was received today from Aviva plc.



1. Reason for the notification     (please tick the
appropriate box or boxes)

An acquisition or disposal voting rights

An acquisition or disposal of financial instruments
which may result in the acquisition of shares already
issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify): INCREASE IN NUMBER OF VOTING   X
SHARES IN ISSUE

2. Full name of person(s) subject to the             Aviva plc & its
notification obligation:                             subsidiaries

3. Full name of shareholder(s) (if different from    Registered Holder:
2.):

                                                     BNY Norwich Union
                                                     Nominees Limited
                                                      6,033,442*


                                                     Chase GA Group
                                                     Nominees Limited
                                                      19,592,672*


                                                     Chase Nominees
                                                     Limited
                                                     881,559*


                                                     CUIM Nominee
                                                     Limited
                                                     4,416,028*


                                                     Vidacos Nominees
                                                     Limited
                                                     65,125*



                                                     *denotes direct
                                                     interest

                                                     BNP Paribas
                                                     - London
                                                     636,429


                                                     Chase Nominees
                                                     Limited
                                                     3,171,774


                                                     State Street
                                                     Nominees Limited
                                                     9,428,137  Vidacos Nominees
                                                     Limited
                                                     1,746,000


4. Date of the transaction (and date on which the    27 October 2008
threshold is crossed or reached if different):

5. Date on which issuer notified:                    28 October 2008


6. Threshold(s) that is/are crossed or reached:      9% to 8% Change
                                                     at Direct Interest
                                                     level


7. Notified details:




A: Voting rights attached to shares

Class/type      Situation previous    Resulting situation after the
of shares       to the Triggering     triggering transaction
                transaction
if possible
using the     Number of   Number of    Number of  Number of voting
ISIN CODE     Shares      Voting       shares     rights
                          Rights
                                       Direct     Direct     Indirect

Ordinary
Shares       46,722,061  46,722,061  30,988,826   30,988,826 14,982,340
GB0007029209



Resulting situation after
the triggering transaction

 %of voting rights

Direct     Indirect

8.84%       4.28%



B: Financial Instruments

Resulting situation after the triggering transaction

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted.



                                   N/A




Total (A+B)

Number of voting rights    % of voting rights

45,971,166                  13.12%




8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :


The voting rights are managed and controlled by Aviva Investors Global
Services Limited, with the following chain of controlled undertakings:-


Aviva Investors Global Services Limited:

  - Aviva plc (Parent Company)

  - Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc)

  - Aviva Investors Holdings Limited (wholly owned subsidiary of Aviva
    Group Holdings Limited)

  - Aviva Investors Global Services Limited (wholly owned subsidiary of
    Aviva Investors Holdings Limited)




Proxy Voting:

9. Name of the proxy holder:                            See Section 3

10. Number of voting rights proxy holder will cease to
hold:

11. Date on which proxy holder will cease to hold voting
rights:



12. Additional      Figures are based on a revised total number of
information:        voting rights of 340,427,481





                                   / Ends /



For further information please contact:


Protherics

Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510

Julie Vickers, Company Secretary            +44 (0)1928 518010


Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113

New York: John Capodanno                    +1 212 850 5600



Or visit  www.protherics.com

                    This information is provided by RNS
          The company news service from the London Stock Exchange

END

Contacts: RNS Customer Services 0044-207797-4400 Email Contact http://www.rns.com

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