RNS Number:0367Q
Protherics PLC
22 September 2003

                         Protherics plc ("Protherics")

                              Directors' dealings

Protherics announces that three directors of Protherics agreed on 19 September
2003 to purchase a total of #99,999 in nominal value of the Protherics 6%
Unsecured Convertible Loan Notes 2010 ("Loan Notes").

Stuart Wallis has agreed to purchase #60,606 in nominal value of the Loan Notes
for consideration of #50,000. Dr. Andrew Heath has agreed to purchase #24,242 in
nominal value of the Loan Notes for consideration of #20,000. Barry Riley has
agreed to purchase #15,151 in nominal value of the Loan Notes for consideration
of #12,500.

The Loan Notes, in accordance with their terms of issue, are convertible into
Ordinary Shares of 2p each in the capital of Protherics ("Ordinary Shares") at a
conversion rate of 25p per Ordinary Share during the period from 19 December
2004 until 19 June 2010. In certain circumstances the Loan Notes will be
convertible from 19 June 2004.

In addition, Protherics announces the take-up by directors of their entitlements
to new Ordinary Shares pursuant to the Cash Placing and Open Offer by Protherics
announced on 7 May 2003. All of the directors named below subscribed their full
entitlement to new Ordinary Shares.

Pursuant to the aforementioned Cash Placing and Open Offer:-

Stuart Wallis subscribed 21,806 Ordinary Shares, taking his aggregate holding to
457,931 Ordinary Shares.

Andrew Heath subscribed 14,999 Ordinary Shares, taking his aggregate holding to
314,999 Ordinary Shares.

David Gration subscribed 2,044 Ordinary Shares, taking his aggregate holding to
42,941 Ordinary Shares.

Barry Riley subscribed 740 Ordinary Shares, taking his aggregate holding to
15,554 Ordinary Shares.

James Christie subscribed 58 Ordinary Shares, taking his aggregate holding to
1,221 Ordinary Shares.

Michael Gatenby subscribed 1,333 Ordinary Shares, taking his aggregate holding
to 27,999 Ordinary Shares.

All Ordinary Shares subscribed pursuant to the Cash Placing and Open Offer were
subscribed at a price of 16p per Ordinary Share and were issued on 4 June 2003.

Disclosure of the subscriptions pursuant to the Cash Placing and Open Offer was
made to the Company on 4 June 2003.

22 September 2003


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