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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-Q
(Mark One)
☒ | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the quarterly period ended June 30, 2024
OR
☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the transition period from _______________ to ______________.
Commission File Number 001-11889
Colorado | | 84-0916344 |
State or other jurisdiction incorporation | | (IRS) Employer Identification Number |
8229 Boone Boulevard, Suite 802
Vienna, Virginia 22182
Address of principal executive offices
(703) 506-9460
Registrant's telephone number, including area code
Securities registered pursuant to Section 12(b) of the Act:
Title of Each Class | | Trading Symbol(s) | | Name of Each Exchange on Which Registered |
Common Stock | | CVM | | NYSE American |
Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports) and (2) had been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes ☒ No ☐
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act:
Large accelerated filer | ☐ | Accelerated filer | ☐ |
Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
| | Emerging growth company | ☐ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the Registrant is a shell company (as defined in Exchange Act Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
Class of Stock | | No. Shares Outstanding | | Date |
Common | | 61,493,229 | | August 8, 2024 |
TABLE OF CONTENTS
PART I FINANCIAL INFORMATION
CEL-SCI CORPORATION |
CONDENSED BALANCE SHEETS |
| | | | | | |
| | JUNE 30, | | | SEPTEMBER 30, | |
ASSETS | | 2024 | | | 2023 | |
| | (UNAUDITED) | | | | |
Current assets: | | | | | | |
Cash and cash equivalents | | $ | 384,652 | | | $ | 4,145,735 | |
Prepaid expenses | | | 551,337 | | | | 520,368 | |
Supplies used for R&D and manufacturing | | | 2,555,249 | | | | 2,248,072 | |
Deposits | | | 51,129 | | | | 4,245 | |
| | | | | | | | |
Total current assets | | | 3,542,367 | | | | 6,918,420 | |
| | | | | | | | |
Finance lease right of use assets | | | 7,800,909 | | | | 9,131,987 | |
Operating lease right of use assets | | | 1,548,010 | | | | 1,698,243 | |
Property and equipment, net | | | 8,613,316 | | | | 10,188,126 | |
Patent costs, net | | | 173,028 | | | | 197,704 | |
Deposits | | | 2,319,101 | | | | 2,319,101 | |
Supplies used for R&D and manufacturing | | | 71,589 | | | | 74,669 | |
| | | | | | | | |
Total assets | | $ | 24,068,320 | | | $ | 30,528,250 | |
| | | | | | | | |
LIABILITIES AND STOCKHOLDERS' EQUITY | | | | | | | | |
| | | | | | | | |
Current liabilities: | | | | | | | | |
Accounts payable | | $ | 1,369,441 | | | $ | 2,009,786 | |
Accrued expenses | | | 1,272,149 | | | | 1,049,581 | |
Due to employees | | | 696,487 | | | | 557,244 | |
Finance lease obligation, current portion | | | 1,949,245 | | | | 1,771,804 | |
Operating lease obligation, current portion | | | 219,019 | | | | 197,431 | |
| | | | | | | | |
Total current liabilities | | | 5,506,341 | | | | 5,585,846 | |
| | | | | | | | |
Finance lease obligations, net of current portion | | | 8,477,784 | | | | 9,949,565 | |
Operating lease obligations, net of current portion | | | 1,486,138 | | | | 1,652,949 | |
Other liabilities | | | 125,000 | | | | 125,000 | |
| | | | | | | | |
Total liabilities | | | 15,595,263 | | | | 17,313,360 | |
| | | | | | | | |
Commitments and contingencies (refer to Note E) | | | | | | | | |
| | | | | | | | |
STOCKHOLDERS' EQUITY | | | | | | | | |
Preferred stock, $0.01 par value; 200,000 shares authorized; 0 shares issued and outstanding | | | - | | | | - | |
Common stock, $0.01 par value; 600,000,000 shares authorized; 54,257,884 and 47,422,304 shares issued and outstanding at June 30, 2024 and September 30, 2023, respectively | | | 542,578 | | | | 474,223 | |
Additional paid-in capital | | | 515,832,848 | | | | 499,832,063 | |
Accumulated deficit | | | (507,902,369 | ) | | | (487,091,396 | ) |
| | | | | | | | |
Total stockholders' equity | | | 8,473,057 | | | | 13,214,890 | |
| | | | | | | | |
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY | | $ | 24,068,320 | | | $ | 30,528,250 | |
| | | | | | | | |
See notes to condensed financial statements. |
CEL-SCI CORPORATION |
CONDENSED STATEMENTS OF OPERATIONS |
NINE MONTHS ENDED JUNE 30, 2024 and 2023 |
(UNAUDITED) |
| | | | | | |
| | 2024 | | | 2023 | |
| | | | | | |
Operating expenses: | | | | | | |
Research and development | | $ | 13,684,204 | | | $ | 17,203,823 | |
General and administrative | | | 6,547,866 | | | | 6,804,729 | |
Total operating expenses | | | 20,232,070 | | | | 24,008,552 | |
| | | | | | | | |
Operating loss | | | (20,232,070 | ) | | | (24,008,552 | ) |
| | | | | | | | |
Interest expense, net | | | (571,102 | ) | | | (493,522 | ) |
Other expense | | | (7,801 | ) | | | (61,525 | ) |
| | | | | | | | |
Net loss | | | (20,810,973 | ) | | | (24,563,599 | ) |
Modification of warrants | | | (659,456 | ) | | | (171,552 | ) |
| | | | | | | | |
Net loss available to common shareholders | | $ | (21,470,429 | ) | | $ | (24,735,151 | ) |
| | | | | | | | |
Net loss per common share – basic and diluted | | $ | (0.42 | ) | | $ | (0.57 | ) |
Weighted average common shares outstanding – basic and diluted | | | 51,479,454 | | | | 43,761,395 | |
| | | | | | | | |
See notes to condensed financial statements. |
CEL-SCI CORPORATION |
CONDENSED STATEMENTS OF OPERATIONS |
THREE MONTHS ENDED JUNE 30, 2024 and 2023 |
(UNAUDITED) |
| | | | | | |
| | 2024 | | | 2023 | |
| | | | | | |
Operating expenses: | | | | | | |
Research and development | | $ | 4,703,160 | | | $ | 5,727,789 | |
General and administrative | | | 1,967,075 | | | | 2,453,968 | |
Total operating expenses | | | 6,670,235 | | | | 8,181,757 | |
| | | | | | | | |
Operating loss | | | (6,670,235 | ) | | | (8,181,757 | ) |
| | | | | | | | |
Interest expense, net | | | (190,705 | ) | | | (181,670 | ) |
Other income (expense) | | | 4,382 | | | | (3,854 | ) |
| | | | | | | | |
Net loss | | | (6,856,558 | ) | | | (8,367,281 | ) |
Modification of warrants | | | (659,456 | ) | | | - | |
| | | | | | | | |
Net loss available to common shareholders | | $ | (7,516,014 | ) | | $ | (8,367,281 | ) |
| | | | | | | | |
Net loss per common share – basic and diluted | | $ | (0.14 | ) | | $ | (0.19 | ) |
Weighted average common shares outstanding – basic and diluted | | | 53,994,384 | | | | 44,254,363 | |
| | | | | | | | |
See notes to condensed financial statements. |
CEL-SCI CORPORATION
STATEMENTS OF STOCKHOLDERS’ EQUITY
(UNAUDITED)
| | | | | | | | Additional | | | | | | | |
| | Common Stock | | | Paid-In | | | Accumulated | | | | |
| | Shares | | | Amount | | | Capital | | | Deficit | | | Total | |
| | | | | | | | | | | | | | | |
BALANCES AT SEPTEMBER 30, 2023 | | | 47,422,304 | | | $ | 474,223 | | | $ | 499,832,063 | | | $ | (487,091,396 | ) | | $ | 13,214,890 | |
| | | | | | | | | | | | | | | | | | | | |
401(k) contributions paid in common stock | | | 17,724 | | | | 177 | | | | 48,730 | | | | - | | | | 48,907 | |
Stock issued to nonemployees for service | | | 88,573 | | | | 886 | | | | 201,421 | | | | - | | | | 202,307 | |
Proceeds from the sale of common stock | | | 2,490,000 | | | | 24,900 | | | | 4,955,100 | | | | - | | | | 4,980,000 | |
Equity based compensation – employees | | | - | | | | - | | | | 1,383,909 | | | | - | | | | 1,383,909 | |
Share issuance costs | | | - | | | | - | | | | (470,229 | ) | | | - | | | | (470,229 | ) |
Net loss | | | - | | | | - | | | | - | | | | (6,709,524 | ) | | | (6,709,524 | ) |
BALANCES AT DECEMBER 31, 2023 | | | 50,018,601 | | | $ | 500,186 | | | $ | 505,950,994 | | | $ | (493,800,920 | ) | | $ | 12,650,260 | |
401(k) contributions paid in common stock | | | 27,373 | | | | 274 | | | | 53,211 | | | | - | | | | 53,485 | |
Stock issued to nonemployees for service | | | 162,744 | | | | 1,627 | | | | 379,243 | | | | - | | | | 380,870 | |
Proceeds from the sale of common stock | | | 3,875,000 | | | | 38,750 | | | | 7,711,250 | | | | - | | | | 7,750,000 | |
Equity based compensation – employees | | | - | | | | - | | | | 1,432,540 | | | | - | | | | 1,432,540 | |
Share issuance costs | | | - | | | | - | | | | (717,621 | ) | | | - | | | | (717,621 | ) |
Net loss | | | - | | | | - | | | | - | | | | (7,244,891 | ) | | | (7,244,891 | ) |
BALANCES AT MARCH 31 , 2024 | | | 54,083,718 | | | $ | 540,837 | | | $ | 514,809,617 | | | $ | (501,045,811 | ) | | $ | 14,304,643 | |
401(k) contributions paid in common stock | | | 45,722 | | | | 457 | | | | 60,120 | | | | - | | | | 60,577 | |
Stock issued to nonemployees for service | | | 70,444 | | | | 704 | | | | 154,951 | | | | - | | | | 155,655 | |
Purchase of stock by officers and directors | | | 58,000 | | | | 580 | | | | 80,040 | | | | - | | | | 80,620 | |
Equity based compensation – employees | | | - | | | | - | | | | 728,120 | | | | - | | | | 728,120 | |
Net loss | | | - | | | | - | | | | - | | | | (6,856,558 | ) | | | (6,856,558 | ) |
BALANCES AT JUNE 30, 2024 | | | 54,257,884 | | | $ | 542,578 | | | $ | 515,832,848 | | | $ | (507,902,369 | ) | | $ | 8,473,057 | |
See notes to condensed financial statements.
CEL-SCI CORPORATION
STATEMENTS OF STOCKHOLDERS’ EQUITY (continued)
(UNAUDITED)
| | | | | | | | Additional | | | | | | | |
| | Common Stock | | | Paid-In | | | Accumulated | | | | |
| | Shares | | | Amount | | | Capital | | | Deficit | | | Total | |
| | | | | | | | | | | | | | | |
BALANCES AT SEPTEMBER 30, 2022 | | | 43,448,317 | | | $ | 434,484 | | | $ | 486,625,816 | | | $ | (454,897,093 | ) | | $ | 32,163,207 | |
| | | | | | | | | | | | | | | | | | | | |
Warrant exercises | | | 217,752 | | | | 2,177 | | | | 445,114 | | | | - | | | | 447,291 | |
Equity based compensation – employees | | | - | | | | - | | | | 1,703,931 | | | | - | | | | 1,703,931 | |
401(k) contributions paid in common stock | | | 21,331 | | | | 213 | | | | 49,965 | | | | - | | | | 50,178 | |
Stock issued to nonemployees for service | | | 40,236 | | | | 402 | | | | 91,221 | | | | - | | | | 91,623 | |
2014 incentive stock forfeited | | | (2,000 | ) | | | (20 | ) | | | (11,080 | ) | | | - | | | | (11,100 | ) |
Net loss | | | - | | | | - | | | | - | | | | (7,853,509 | ) | | | (7,853,509 | ) |
BALANCES AT DECEMBER 31, 2022 | | | 43,725,636 | | | $ | 437,256 | | | $ | 488,904,967 | | | $ | (462,750,602 | ) | | $ | 26,591,621 | |
| | | | | | | | | | | | | | | | | | | | |
Equity based compensation – employees | | | - | | | | - | | | | 1,743,288 | | | | - | | | | 1,743,288 | |
401(k) contributions paid in common stock | | | 23,627 | | | | 236 | | | | 54,629 | | | | - | | | | 54,865 | |
Stock issued to nonemployees for service | | | 38,562 | | | | 386 | | | | 100,249 | | | | - | | | | 100,635 | |
Net loss | | | - | | | | - | | | | - | | | | (8,342,809 | ) | | | (8,342,809 | ) |
BALANCES AT MARCH 31 , 2023 | | | 43,787,825 | | | $ | 437,878 | | | $ | 490,803,133 | | | $ | (471,093,411 | ) | | $ | 20,147,600 | |
| | | | | | | | | | | | | | | | | | | | |
Equity based compensation – employees | | | - | | | | - | | | | 1,551,319 | | | | - | | | | 1,551,319 | |
401(k) contributions paid in common stock | | | 12,855 | | | | 129 | | | | 52,534 | | | | - | | | | 52,663 | |
Stock issued to nonemployees for service | | | 36,523 | | | | 365 | | | | 135,304 | | | | - | | | | 135,669 | |
Proceeds from the sale of common stock | | | 913,234 | | | | 9,132 | | | | 1,543,365 | | | | - | | | | 1,552,497 | |
2014 Incentive Stock Forfeited | | | (2,000 | ) | | | (20 | ) | | | (11,080 | ) | | | - | | | | (11,100 | ) |
Share issuance costs | | | - | | | | - | | | | (271,968 | ) | | | - | | | | (271,968 | ) |
Net loss | | | - | | | | - | | | | - | | | | (8,367,281 | ) | | | (8,367,281 | ) |
BALANCES AT JUNE 30 , 2023 | | | 44,748,437 | | | $ | 447,484 | | | $ | 493,802,607 | | | $ | (479,460,692 | ) | | $ | 14,789,399 | |
See notes to condensed financial statements.
CEL-SCI CORPORATION |
CONDENSED STATEMENTS OF CASH FLOWS |
NINE MONTHS ENDED JUNE 30, 2024 and 2023 |
(UNAUDITED) |
| | | | | | |
| | 2024 | | | 2023 | |
| | | | | | |
Net loss | | $ | (20,810,973 | ) | | $ | (24,563,599 | ) |
Adjustments to reconcile net loss to net cash used in operating activities: | | | | | | | | |
Depreciation and amortization | | | 2,977,603 | | | | 2,959,681 | |
Non-cash lease expense | | | 5,008 | | | | 12,788 | |
Share-based payments for services | | | 778,571 | | | | 473,723 | |
Equity-based compensation | | | 3,544,569 | | | | 4,976,338 | |
Common stock contributed to 401(k) plan (Increase)/decrease in assets: | | | 162,969 | | | | 157,706 | |
Prepaid expenses | | | (15,708 | ) | | | 208,419 | |
Supplies used for R&D and manufacturing | | | (304,097 | ) | | | (24,491 | ) |
Deposits | | | (46,884 | ) | | | (2,342,951 | ) |
Increase/(decrease) in liabilities: | | | | | | | | |
Accounts payable | | | (592,370 | ) | | | 66,616 | |
Accrued expenses | | | 167,568 | | | | 243,800 | |
Due to employees | | | 139,243 | | | | 28,173 | |
| | | | | | | | |
Net cash used in operating activities | | | (13,994,502 | ) | | | (17,803,797 | ) |
| | | | | | | | |
CASH FLOWS FROM INVESTING ACTIVITIES: | | | | | | | | |
Purchases of property and equipment | | | (75,122 | ) | | | (361,892 | ) |
Expenditures for patent costs | | | (13,211 | ) | | | - | |
| | | | | | | | |
Net cash used in investing activities | | | (88,333 | ) | | | (361,892 | ) |
| | | | | | | | |
CASH FLOWS FROM FINANCING ACTIVITIES: | | | | | | | | |
Proceeds from issuance of common stock | | | 12,730,000 | | | | 1,552,497 | |
Payments of stock issuance costs | | | (1,173,577 | ) | | | (213,796 | ) |
Proceeds from the purchase of stock by officers and directors | | | 80,620 | | | | - | |
Proceeds from the exercise of warrants | | | - | | | | 447,291 | |
Payments on obligations under finance leases | | | (1,315,291 | ) | | | (1,157,371 | ) |
| | | | | | | | |
Net cash provided by financing activities | | | 10,321,752 | | | | 628,621 | |
| | | | | | | | |
NET DECREASE IN CASH AND CASH EQUIVALENTS | | | (3,761,083 | ) | | | (17,537,068 | ) |
| | | | | | | | |
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD | | | 4,145,735 | | | | 22,672,138 | |
| | | | | | | | |
CASH AND CASH EQUIVALENTS, END OF PERIOD | | $ | 384,652 | | | $ | 5,135,070 | |
| | | | | | | | |
See notes to condensed financial statements. |
CEL-SCI CORPORATION
CONDENSED STATEMENTS OF CASH FLOWS
NINE MONTHS ENDED JUNE 30, 2024 and 2023
(UNAUDITED)
| | 2024 | | | 2023 | |
SUPPLEMENTAL SCHEDULE OF NON-CASH INVESTING AND FINANCING ACTIVITIES: | | | | | | |
Assets purchased under finance leases | | $ | 20,797 | | | $ | - | |
Finance lease obligation included in accounts payable | | $ | 1,296 | | | $ | 927 | |
Property and equipment included in current liabilities | | $ | 2,770 | | | | - | |
Consulting services paid with issuance of common stock | | $ | 738,832 | | | $ | 327,927 | |
Accrued consulting services to be paid with common stock | | $ | 110,000 | | | $ | 110,000 | |
Financing costs included in current liabilities | | $ | 91,975 | | | $ | 58,172 | |
| | | | | | | | |
Cash paid for interest | | $ | 706,517 | | | $ | 809,495 | |
| | | | | | | | |
See notes to condensed financial statements. |
CEL-SCI CORPORATION
NOTES TO CONDENSED FINANCIAL STATEMENTS
NINE MONTHS ENDED JUNE 30, 2024 AND 2023 (UNAUDITED)
A. BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Basis of Presentation
The accompanying condensed financial statements of CEL-SCI Corporation (the “Company”) are unaudited and certain information and footnote disclosures normally included in the annual financial statements prepared in accordance with accounting principles generally accepted in the United States of America have been omitted pursuant to the rules and regulations of the Securities and Exchange Commission. While management of the Company believes that the disclosures presented are adequate to make the information presented not misleading, these interim condensed financial statements should be read in conjunction with the financial statements and notes included in the Company’s annual report on Form 10-K for the year ended September 30, 2023.
In the opinion of management, the accompanying unaudited condensed financial statements contain all adjustments (all of which are of a normal recurring nature) and disclosures necessary for a fair presentation of the Company’s financial position as of June 30, 2024 and the results of its operations for the nine months then ended. The condensed balance sheet as of September 30, 2023 is derived from the September 30, 2023 audited financial statements.
Due to recurring losses from operations and future liquidity needs, there is substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of this uncertainty. Refer to discussion in Note B.
Summary of Significant Accounting Policies:
Cash and Cash Equivalents – Cash and cash equivalents consist principally of unrestricted cash on deposit and short-term money market funds. The Company considers all highly liquid investments with a maturity when purchased of less than three months to be cash equivalents.
Property and Equipment – Property and equipment is recorded at cost and depreciated using the straight-line method over estimated useful lives of five to seven years. Leasehold improvements are depreciated over the shorter of the estimated useful life of the asset or the term of the lease. Repairs and maintenance which do not extend the life of the asset are expensed when incurred. Property and equipment is reviewed on a quarterly basis to determine if any of the assets are impaired.
Supplies used for R&D and manufacturing – Supplies are consumable items kept on hand to support the Company’s R&D and manufacturing operations. Supplies are recorded at cost and are charged to expense as they are used in operations.
Patents – Patent expenditures are capitalized and amortized using the straight-line method over the shorter of the expected useful life or the legal life of the patent (17 years). In the event changes in technology or other circumstances impair the value or life of the patent, appropriate adjustments to the asset value and period of amortization are made. An impairment loss is recognized when estimated future undiscounted cash flows expected to result from the use of the asset, and from its disposition, are less than the carrying value of the asset. The amount of the impairment loss would be the difference between the estimated fair value of the asset and its carrying value.
Leases – The Company accounts for contracts that convey the right to control the use of identified property, plant or equipment over a period of time in exchange for consideration as leases upon inception. The Company leases certain real estate, machinery, laboratory equipment and office equipment over varying periods. Many of these leases include an option to either renew or terminate the lease. For purposes of calculating lease liabilities, these options are included in the lease term when it is reasonably certain that the Company will exercise such options. The incremental borrowing rate utilized to calculate the lease liabilities is based on the information available at the commencement date, as most of the leases do not provide an implicit borrowing rate. Short-term leases, defined as leases with initial terms of 12 months or less, are not reflected on the balance sheet. Lease expense for such short-term leases is not material.
Share-Based Compensation – Compensation cost for all share-based awards is measured at fair value as of the grant date in accordance with the provisions of ASC 718, Compensation – Stock Compensation (“ASC 718”). The fair value of stock options is calculated using the Black-Scholes option pricing model. The Black-Scholes model requires five input variables: the strike price of an option, the current stock price, the time to expiration, the risk-free rate, and the volatility. The share-based compensation cost is recognized using the straight-line method as expense over the requisite service or vesting period.
The Company has Incentive Stock Option Plans, Non-Qualified Stock Option Plans, Stock Compensation Plans, Stock Bonus Plans and an Incentive Stock Bonus Plan. These Plans are collectively referred to as the “Plans”. All Plans have been approved by the Company’s stockholders.
The Company’s stock options are not transferable, and the actual value of the stock options that an employee may realize, if any, will depend on the excess of the market price on the date of exercise over the exercise price. For options issued with service conditions only, the Company has based its assumption for stock price volatility on the variance of daily closing prices of the Company’s stock. The risk-free interest rate assumption is based on the U.S. Treasury rate at the date of grant with the term equal to the expected life of the option. Forfeitures are accounted for when they occur. The expected term of options represents the period that options granted are expected to be outstanding and has been determined based on an analysis of historical exercise behavior. If any of the assumptions used in the Black-Scholes model change significantly, share-based compensation expense for new awards may differ materially in the future from that recorded in the current period.
Restricted stock granted under the Incentive Stock Bonus Plan and options granted under the Non-Qualified Stock Option Plans are subject to service, performance and market conditions and meet the classification of equity awards. These awards were measured at fair value on the grant dates using a Monte Carlo simulation for issuances where the attainment of performance criteria is uncertain. The total compensation cost will be expensed over the estimated requisite service period.
Research and Development Costs – Research and development costs are expensed as incurred. Management accrues Clinical Research Organization (“CRO”) expenses and clinical trial study expenses based on services performed and relies on the CROs to provide estimates of those costs applicable to the completion stage of a study. Estimated accrued CRO costs are subject to revisions as such studies progress to completion. The Company records revisions to estimated expense in the period in which the facts that give rise to the revision become known.
Net Loss Per Common Share – The Company calculates net loss per common share in accordance with ASC 260, Earnings Per Share. Basic and diluted net loss per common share was determined by dividing net loss applicable to common shareholders by the weighted average number of common shares outstanding during the period. The Company’s potentially dilutive shares, which include outstanding common stock options, unvested restricted stock and common stock warrants, have not been included in the computation of diluted net loss per share for all periods as the result would be anti-dilutive.
Income Taxes – The Company accounts for income taxes in accordance with the provisions of ASC 740, Income Taxes, on a tax jurisdiction basis. Deferred tax assets and liabilities are recognized for future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases and operating and tax loss carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. The Company records a valuation allowance to reduce the deferred tax assets to the amount that is more likely than not to be recognized. A full valuation allowance was recorded against the deferred tax assets as of June 30, 2024 and September 30, 2023.
Impairment of long-lived assets – CEL-SCI’s fixed assets are made up of leasehold improvements, furniture, and equipment. ASC 360-10 requires that a long-lived asset group be reviewed for impairment only when events or changes in circumstances indicate that the carrying amount of the long-lived asset (group) might not be recoverable. CEL-SCI’s recurring losses are a triggering event that could indicate impairment of long-lived assets such as fixed assets. CEL-SCI reviews these assets to determine if events or changes in circumstances indicate the existence of impairment. If indicators of impairment exist, the Company tests for recoverability, then, if necessary, measures and records the impairment. The amount of the impairment loss would be the amount by which the carrying amount of the asset (group) exceeds its fair value.
Use of Estimates – The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and the accompanying disclosures. These estimates are based on management’s best knowledge of current events and actions the Company may undertake in the future. Estimates are used in accounting for, among other items, inventory obsolescence, accruals, stock options, useful lives for depreciation and amortization of long-lived assets, right of use assets and lease liabilities, deferred tax assets and the related valuation allowance. Actual results could differ from estimates, although management does not generally believe such differences would materially affect the financial statements in any given year. Additionally, in calculating the right of use assets and lease liabilities, estimates and assumptions were used to determine the incremental borrowing rates and the expected lease terms. The Company considers the estimates used in valuing the stock options and the lease assets and liabilities to be significant.
Recently Adopted Accounting Standards
In June 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update No. 2016-13, Financial Instruments – Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments (“ASU 2016-13”). ASU 2016-13 requires a financial asset (or a group of financial assets) measured at amortized cost basis to be presented at the net amount expected to be collected. The amendments in ASU 2016-13 replace the incurred loss impairment methodology in current U.S. GAAP with a methodology that reflects expected credit losses and requires consideration of a broader range of reasonable and supportable information. ASU 2016-13 was effective for SEC filers, excluding smaller reporting companies, for fiscal years beginning after December 15, 2019, including interim periods within those fiscal years. As a smaller reporting company, the Company was permitted to adopt the new standard for fiscal years beginning after December 15, 2022, including interim periods within those fiscal years. Effective October 1, 2023, the Company adopted ASU 2016-13 using a modified retrospective transition method. The adoption of ASU 2016-13 had no impact on the Company’s financial position, results of operations, or cash flows.
New Accounting Pronouncements
In November 2023, the FASB issued Accounting Standards Update No. 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures (“ASU 2023-07”), which expands disclosures about a public entity’s reportable segments and requires more enhanced information about a reportable segment’s expenses, interim segment profit or loss, and how a public entity’s chief operating decision maker uses reported segment profit or loss information in assessing segment performance and allocating resources. The update will be effective for annual periods beginning after December 15, 2023 and interim periods beginning after December 15, 2024. The Company is assessing the effect of this update on the condensed financial statement disclosures.
In December 2023, the FASB issued Accounting Standards Update No. 2023-09, Improvements to Income Tax Disclosures, which require greater disaggregation of income tax disclosures related to the income tax rate reconciliation and income taxes paid. The update will be effective for annual periods beginning after December 15, 2024. The guidance should be applied on a prospective basis with the option to apply the standard retrospectively. Early adoption is permitted. The Company is currently evaluating the impact that this change will have on the Company's disclosures.
B. LIQUIDITY
The Company has incurred significant costs since its inception for the acquisition of certain proprietary technology and scientific knowledge relating to the human immunological defense system, patent applications, research and development, administrative costs, construction and expansion of manufacturing and laboratory facilities and conducting clinical trials. The Company has funded such costs primarily with proceeds from loans and the public and private sale of its securities. The Company will be required to raise additional capital or find additional long-term financing to continue with its efforts to bring Multikine, the Company’s lead investigational therapy, to market. The ability to raise capital may be dependent upon market conditions that are outside the control of the Company. The ability of the Company to obtain approval from any regulatory agency for the sale of products to be developed on a commercial basis is uncertain. Ultimately, the Company must complete the development of its products, obtain the appropriate regulatory approvals and obtain sufficient revenues to support its cost structure.
To finance the Company through marketing approval, the Company plans to raise additional capital in the form of corporate partnerships, and debt and/or equity financings. The Company believes that it will be able to obtain additional financing because it has done so consistently in the past and because Multikine showed great survival benefit in the Phase 3 study in one of the two treatment arms for advanced primary head and neck cancer. However, there can be no assurance that the Company will be successful in raising additional funds on a timely basis or that the funds will be available to the Company on acceptable terms or at all. If the Company does not raise the necessary amounts of money, it may have to curtail its operations until such time as it is able to raise the required funding.
Due to the Company’s recurring losses from operations and future liquidity needs, there is substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.
C. STOCKHOLDERS’ EQUITY
Proceeds from the Sale of Common Stock
In February 2024, the Company sold 3,875,000 shares of common stock at a public offering price of $2.00 per share and received proceeds of approximately $7.0 million, net of issuance costs of approximately $0.7 million.
In November 2023, the Company sold 2,490,000 shares of common stock at a public offering price of $2.00 per share and received proceeds of approximately $4.5 million, net of issuance costs of approximately $0.5 million.
In April 2023, the Company sold 794,117 shares of common stock at a public offering price of $1.70 per share and received proceeds of approximately $1.4 million. The Company granted the underwriters a 30-day option to purchase up to 119,117 additional shares of common stock to cover over-allotments. The underwriter fully exercised this option in May 2023, resulting in additional proceeds to the Company of approximately $200,000. The Company incurred issuance costs of approximately $0.2 million related to this offering.
Equity Compensation
Underlying share information for equity compensation plans as of June 30, 2024 is as follows:
Name of Plan | | Total Shares Reserved Under Plans | |
Incentive Stock Option Plans | | | 138,400 | |
Non-Qualified Stock Option Plans | | | 17,787,200 | |
Stock Bonus Plans | | | 1,283,760 | |
Stock Compensation Plans | | | 634,000 | |
Incentive Stock Bonus Plan | | | 640,000 | |
Stock option activity:
| | Nine months ended June 30, | |
| | 2024 | | | 2023 | |
Options granted | | | 1,967,500 | | | | 6,500 | |
Options exercised | | | - | | | | - | |
Options forfeited | | | 293,000 | | | | 179,832 | |
Options expired | | | 27,075 | | | | 58,787 | |
| | Three Months Ended June 30, | |
| | 2024 | | | 2023 | |
Options granted | | | 1,964,500 | | | | 2,000 | |
Options exercised | | | - | | | | - | |
Options forfeited | | | 240,000 | | | | 57,500 | |
Options expired | | | 40 | | | | 13,383 | |
On March 1, 2024, the Company accelerated the vesting of 234,332 stock options issued to directors to vest on April 19, 2024. The Company concluded that the change in vesting of the options should be treated as a modification in accordance with ASC 718. As such, the Company revalued the options as of March 1, 2024 (the modification date) and subtracted any compensation cost already recognized prior to the modification date. This resulted in remaining compensation cost of approximately $260,000 that was amortized on a straight-line basis over the remaining service period. The remaining compensation cost of approximately $101,000 as of March 31, 2024 was expensed during the three months ended June 30, 2024.
Share-Based Compensation Expense:
| | Nine months ended June 30, | |
| | 2024 | | | 2023 | |
Employees | | $ | 3,544,569 | | | $ | 4,976,338 | |
Non-employees | | $ | 600,841 | | | $ | 473,723 | |
| | Three Months Ended June 30, | |
| | 2024 | | | 2023 | |
Employees | | $ | 728,120 | | | $ | 1,540,219 | |
Non-employees | | $ | 230,678 | | | $ | 188,001 | |
Employee compensation expense includes the expense related to options and restricted stock that is expensed over the vesting periods. Non-employee expense includes the expense related to options and stock issued to consultants expensed over the period of the related service contracts.
Warrants and Non-Employee Options
The following chart represents the warrants and non-employee options outstanding at June 30, 2024:
Warrant/ Options | | Issue Date | | Shares Issuable upon Exercise of Warrants/ Options | | | Exercise Price | | | Expiration Date | |
Series N | | 8/18/2008 | | | 85,339 | | | $ | 3.00 | | | 8/18/2026 | |
Series UU | | 6/11/2018 | | | 93,603 | | | $ | 2.80 | | | 6/30/2026 | |
Series X | | 1/13/2016 | | | 120,000 | | | $ | 9.25 | | | 7/13/2026 | |
Series Y | | 2/15/2016 | | | 26,000 | | | $ | 12.00 | | | 8/15/2026 | |
Series MM | | 6/22/2017 | | | 333,432 | | | $ | 1.86 | | | 6/22/2026 | |
Series NN | | 7/24/2017 | | | 200,087 | | | $ | 2.52 | | | 7/24/2026 | |
Series RR | | 10/30/2017 | | | 234,009 | | | $ | 1.65 | | | 10/30/2026 | |
Consultant Options | | 7/28/2017 – 9/2/2023 | | | 110,000 | | | | $1.39- $2.18 | | | 7/27/2027 - 9/1/2028 | |
1. Equity Warrants
Changes in Equity Warrants
No warrants recorded as equity were exercised during the nine months ended June 30, 2024. The following warrants recorded as equity were exercised during the nine months ended June 30, 2023.
Warrants | | Warrants Exercised | | | Exercise Price | | | Proceeds | |
Series RR | | | 17,752 | | | $ | 1.65 | | | $ | 29,291 | |
Series SS | | | 200,000 | | | $ | 2.09 | | | | 418,000 | |
| | | 217,752 | | | | | | | $ | 447,291 | |
No warrants recorded as equity expired during the nine and three months ended June 30,2024. On February 5, 2023, 600 Series TT warrants, with an exercise price of $2.24, expired.
On May 4, 2024, the Company modified the terms of Series UU, X, Y, N, MM, NN and RR warrants by extending the expiration dates by twenty-four (24) months from their current expiration dates. The incremental cost of this extension was approximately $659,455, which was recorded as a deemed dividend in the financial statements for the nine and three months ended June 30, 2024. The Series N, X, MM, NN, RR and UU warrants are held by current Officers of the Company.
On October 28, 2022, the expiration date of the Series RR warrants was extended two years from October 30, 2022 to October 30, 2024. The incremental cost of this extension was approximately $172,000, which was recorded as a deemed dividend. The Series RR warrants are held by current Officers of the Company.
2. Options and Shares Issued to Consultants
During the nine months ended June 30, 2024 and 2023, the Company issued 321,761 and 115,321 shares, respectively, of restricted common stock to consultants for services. The weighted average grant date fair value of the shares issued to consultants was $1.84 and $2.45 during the nine months ended June 30, 2024 and 2023, respectively. During the three months ended June 30, 2024 and 2023, the Company issued 70,444 and 36,523 shares, respectively, of restricted common stock to consultants for services. The weighted average grant date fair value of the shares issued to consultants was $1.33 and $2.41 during the three months ended June 30, 2024 and 2023, respectively.
No options were issued to a consultant during the nine months ended June 30, 2024. During the nine months ended June 30, 2023, 5,000 options with an exercise price of $11.61 issued to a consultant expired.
During the nine months ended June 30, 2024 and 2023, the Company recorded total expense of approximately $601,000 and $474,000, respectively, relating to the share-based compensation under various consulting agreements. During the three months ended June 30, 2024 and 2023, the Company recorded total expense of approximately $231,000 and $188,000, respectively, relating to the share-based compensation under these consulting agreements. On June 30, 2024 and September 30, 2023, consulting fees of approximately $221,000 and $205,000, respectively, are included in current assets as prepaid expenses and will be amortized over the remaining service periods.
D. RELATED PARTY TRANSACTIONS
During the nine and three months ended June 30, 2024, certain officers and directors purchased 58,000 shares of restricted common stock at an aggregated fair market value of approximately $80,620. No restricted shares of the Company’s common stock were purchased by related parties during the nine and three months ended June 30, 2023.
On May 4, 2024, the Company modified the terms of Series UU, X, Y, N, MM, NN and RR warrants by extending the expiration dates by twenty-four (24) months from their current expiration dates. The incremental cost of this extension was approximately $659,455, which was recorded as a deemed dividend in the financial statements for the three months ended June 30, 2024. The Series N, X, MM, NN, RR and UU warrants are held by Geert Kersten, Patricia Prichep (current Officers of the Company) and the de Clara Trust, of which the Company’s CEO, Geert Kersten, is a beneficiary.
On October 28, 2022, the expiration date of the Series RR warrants was extended two years from October 30, 2022 to October 30, 2024 (Note C). The incremental cost of this extension was approximately $172,000, which was recorded as a deemed dividend.
E. COMMITMENTS AND CONTINGENCIES
Clinical Research Agreement
Under co-development and revenue sharing agreements with Ergomed, Ergomed agreed to contribute up to $12 million towards the Company’s Phase 3 Clinical Trial in the form of discounted clinical services in exchange for a single digit percentage of milestone and royalty payments, up to a specific maximum amount. The Company accounted for the co-development and revenue sharing agreements in accordance with ASC 808, Collaborative Arrangements. The Company determined the payments to Ergomed are within the scope of ASC 730, Research and Development. Therefore, the Company records the discount on the clinical services as a credit to research and development expense on its statements of operations. Since the inception of the agreement with Ergomed, the Company has incurred research and development expenses of approximately $35.8 million for Ergomed’s services. This amount is net of Ergomed’s discount of approximately $11.9 million. During the nine months ended June 30, 2024 and 2023, the Company recorded, net of Ergomed’s discount, approximately $0.1 million for each period as research and development expense related to Ergomed’s services. During the three months ended June 30, 2024 the Company did not record any research and development expense related to Egromed’s services and during three months ended June 30, 2023, the Company recorded, net of Ergomed’s discount, less than $0.1 million as research and development expense related to Ergomed’s services.
Lease Agreements
The Company leases a manufacturing facility near Baltimore, Maryland (the San Tomas lease). The building was remodeled in accordance with the Company’s specifications so that it can be used by the Company to manufacture Multikine for the Company’s Phase 3 clinical trial and sales of the drug if approved by any regulatory agency. The lease is for a term of twenty years and requires annual base rent to escalate each year at 3%. The Company is required to pay all real estate and personal property taxes, insurance premiums, maintenance expenses, repair costs and utilities. The lease allows the Company, at its election, to extend the lease for two ten-year periods or to purchase the building at the end of the 20-year lease, which expires in October 2028. The renewal options are not included in the calculation of the right of use asset and lease liability because exercise of those options is not reasonably certain.
The San Tomas lease is classified as a finance lease on the Company’s balance sheet, as well as several other smaller finance leases for office equipment. The finance right of use assets are being depreciated using the straight-line method over the underlying lease terms. Total cash paid related to finance leases during the nine months ended June 30, 2024 and 2023 was approximately $2.0 and $1.9 million, respectively, of which approximately $0.7 and $0.8 million was for interest, respectively, in each nine-month period. As of June 30, 2024, the weighted average discount rate of the Company’s finance leases is 8.46% and the weighted average time to maturity is 4.34 years.
On January 11, 2023, the Company was required to deposit approximately $2.3 million to its landlord, equivalent to one year’s rent, for falling below the stipulated cash threshold in accordance with the San Tomas lease. The amount will be included as an asset on the balance sheet until the Company meets the minimum cash balance required and the deposit is returned.
Approximate future minimum lease payments under finance leases as of June 30, 2024 are as follows:
Three months ending September 30, 2024 | | $ | 666,000 | |
Year ending September 30, | | | | |
2025 | | | 2,747,000 | |
2026 | | | 2,838,000 | |
2027 | | | 2,929,000 | |
2028 | | | 3,021,000 | |
2029 | | | 255,000 | |
Total future minimum lease obligation | | | 12,456,000 | |
Less imputed interest on finance lease obligations | | | (2,029,000 | ) |
Net present value of financing lease obligations | | | 10,427,000 | |
Less net present value of financing lease obligations – current portion | | | (1,949,000 | ) |
Net present value of financing lease obligations - non-current portion | | $ | 8,478,000 | |
The Company leases two facilities under operating leases. The lease for the Company’s office headquarters will expire on November 30, 2025. The lease for its research and development laboratory was renewed in September 2021 for an additional ten years and will expire on February 29, 2032. The renewal was considered a modification for accounting purposes and the right of use asset and liability were remeasured as of the date of the renewal. The operating leases include escalating rental payments. The Company is recognizing the related rent expense on a straight-line basis over the terms of the leases. The Company incurred lease expense for operating leases of approximately $0.3 million for both the nine months ended June 30, 2024 and 2023. Total cash paid related to operating leases during the nine months ended June 30, 2024 and 2023 was approximately $0.3 million for each period. The weighted average discount rate of the Company’s operating leases is 10.19% and the weighted average time to maturity is 7.16 years.
As of June 30, 2024, approximate future minimum lease payments under operating leases are as follows:
Three months ending September 30, 2024 | | $ | 90,000 | |
Year ending September 30, | | | | |
2025 | | | 366,000 | |
2026 | | | 287,000 | |
2027 | | | 277,000 | |
2028 | | | 285,000 | |
2029 | | | 294,000 | |
Thereafter | | | 746,000 | |
Total future minimum lease obligation | | | 2,345,000 | |
Less imputed interest on operating lease obligation | | | (640,000 | ) |
Net present value of operating lease obligations | | | 1,705,000 | |
Less net present value of operating lease obligations - current portion | | | (219,000 | ) |
Net present value of operating lease obligations - non-current portion | | $ | 1,486,000 | |
G. PATENTS
During the nine and three months ended June 30, 2024 and 2023, there was no impairment of patent costs. The weighted average amortization period for patents is approximately 8 years. For the nine months ended June 30, 2024 and 2023, amortization of patent costs totaled approximately $25,000 and $29,000, respectively. For the three months ended June 30, 2024 and 2023, amortization of patent costs totaled approximately $7,000 and $9,000, respectively. The total estimated future amortization is as follows:
Three months ending September 30, 2024 | | $ | 8,000 | |
Year ending September 30, | | | | |
2025 | | | 29,000 | |
2026 | | | 25,000 | |
2027 | | | 22,000 | |
2028 | | | 19,000 | |
2029 | | | 16,000 | |
Thereafter | | | 54,000 | |
Total | | $ | 173,000 | |
H. LOSS PER COMMON SHARE
Basic loss per share is computed by dividing net loss available to common stockholders by the weighted average number of common shares outstanding during the period. The Company’s potentially dilutive shares, which include outstanding common stock options, common stock warrants and unvested restricted stock are not included in the computation of diluted net loss per share if their effect would be anti-dilutive.
The following table provides a reconciliation of the numerators and denominators of the basic and diluted loss per-share computations:
| | Nine Months Ended | | | Three Months Ended | |
| | June 30, | | | June 30, | |
Loss per share – basic and diluted | | 2024 | | | 2023 | | | 2024 | | | 2023 | |
Net loss available to common – basic and diluted | | $ | (21,470,429 | ) | | $ | (24,735,151 | ) | | $ | (7,516,014 | ) | | $ | (8,367,281 | ) |
Weighted average shares outstanding – basic and diluted | | | 51,479,454 | | | | 43,761,395 | | | | 53,994,384 | | | | 44,254,363 | |
Basic and diluted loss per common share | | $ | (0.42 | ) | | $ | (0.57 | ) | | $ | (0.14 | ) | | $ | (0.19 | ) |
In accordance with the contingently issuable shares guidance of ASC 260, Earnings Per Share, the calculation of diluted net earnings (loss) per share excludes the following securities because their inclusion would have been anti-dilutive as of June 30 :
| | 2024 | | | 2023 | |
Options and Warrants | | | 17,497,453 | | | | 13,824,365 | |
Unvested Restricted Stock | | | 147,250 | | | | 147,250 | |
Total | | | 17,644,703 | | | | 13,971,615 | |
J. SUBSEQUENT EVENTS
On July 11, 2024, Geert Kersten, the Company’s Chief Executive Officer and a director, loaned the Company $200,000. On July 18, 2024, Mr. Kersten loaned the Company an additional $250,000. These amounts were repaid on July 30, 2024.
On July 29, 2024, the Company sold 3,715,000 shares of common stock at an offering price of $1.00 per share, and pre-funded warrants to purchase up to 7,130,000 shares of common stock, at an offering price of $0.99 per pre-funded warrant, for gross proceeds of approximately $10.8 million.
Item 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
Company Overview and Product Candidates
CEL-SCI Corporation is a late clinical-stage biotechnology company dedicated to research and development directed at improving the treatment of cancer and other diseases by using the immune system, the body’s natural defense system. CEL-SCI is currently focused on the development of the following product candidates and technologies:
| 1) | Multikine, an investigational immunotherapy under development for the potential treatment of certain head and neck cancers; and |
| | |
| 2) | L.E.A.P.S. (Ligand Epitope Antigen Presentation System) technology, or LEAPS, with several product candidates under development for the potential treatment of rheumatoid arthritis. |
Multikine (Leukocyte Interleukin, Injection) is the full name of this investigational therapy, which, for simplicity, is referred to in this report as Multikine. Multikine is the trademark that the Company has registered for this investigational therapy, and this proprietary name is subject to FDA review under the Company’s future anticipated regulatory submission for approval. None of the Company’s product candidates have been approved for sale, barter or exchange by the Food and Drug Administration (FDA) or any other regulatory agency for any use to treat disease in humans nor has the safety or efficacy of these products been established for any use. There can be no assurance that obtaining marketing approval from the FDA in the United States and by comparable agencies in most foreign countries will be granted.
MULTIKINE, THE PHASE III CLINICAL TRIAL RESULTS, AND PATH FORWARD
Immunotherapy is a large, high growth market. Immunotherapies use the patient’s own immune system to fight disease. These “targeted therapies” are at the forefront of modern cancer research. A recent Bloomberg report from January 2023 asserted that:
The global cancer immunotherapy market is expected to reach USD $196.45 billion by 2030, registering CAGR of 7.2% during the forecast period, according to a new report by Grand View Research, Inc. The rising adoption of immunotherapy over other therapy options for cancer owing to its targeted action is anticipated to increase the adoption during the forecast period. Moreover, increasing regulatory approvals from authoritarian establishments for novel immunotherapy used for oncology is also expected to further fuel the market growth. (https://www.bloomberg.com/press-releases/2023-01-18/cancer-immunotherapy-market-worth-196-45-billion-by-2030-grand-view-research-inc)
CEL-SCI hopes to participate in this growing market with its lead investigational therapy Multikine® (Leukocyte Interleukin, Injection). Multikine is unique among approved cancer immunotherapies because it is given first, right after diagnosis, before any other treatment including surgery.
Multikine has been tested in approximately 740 patients in Phase 1, 2 and 3 clinical studies conducted in the U.S., Canada, Europe, Israel and Asia. In these studies, it has been administered in multiple doses by various routes and various frequencies to determine its safety and efficacy. The data from these studies allowed CEL-SCI to determine the patient population most responsive to Multikine and most likely to benefit from it. The target population is newly diagnosed advanced primary head and neck cancer patients with no lymph node involvement (determined via PET imaging) and with low PD-L1 tumor expression (determined via biopsy), two features that physicians routinely assess at baseline as part of standard practice.
In the target patient population CEL-SCI believes Multikine significantly extended life. In the Phase III study, CEL-SCI observed a 73% survival rate with Multikine vs. only 45% without Multikine at 5 years after treatment, and a Hazard ratio of 0.35 (95% CIs [0.19, 0.66]).
CEL-SCI completed a bias analysis for the target population in the Phase III study in preparation for submission of data to regulatory agencies including the FDA for confirmatory registration study. The detailed data on parameters including patient age, sex, race, tumor locations, and staging demonstrate balance between the treatment and control arms. Therefore, no bias was found, which supports confidence in Multikine’s efficacy results.
CEL-SCI applied to the FDA for a 212-patient randomized controlled confirmatory registration study focusing only on those patients in the target population, this accounts for approximately 100,000 patients worldwide per year. In May 2024, CEL-SCI announced that the FDA indicated CEL-SCI may move forward with a confirmatory registration study of Multikine in the target population.
What is Multikine and who is it for? Multikine is a biological medicinal immunotherapy comprised of a mixture of natural cytokines and small biological molecules. Multikine is injected around the tumor and adjacent lymph nodes for three weeks as a first-line treatment before the standard of care (SOC), which is surgery followed by either radiotherapy or chemoradiotherapy. Multikine’s rationale for use is to incite a locoregional immune response against the tumor before the local immune system has been compromised by the standard of care and/or disease progression.
The Multikine target population is not yet treated adult patients with resectable locally advanced primary squamous cell carcinoma of the head and neck (SCCHN) in the oral cavity and who have:
| · | No lymph node involvement (via PET imaging) |
| · | Low PD-L1 tumor expression (TPS<10) (via biopsy) |
PD-L1 is a protein receptor on the tumor surface that helps the tumor repel cells of the immune system. CEL-SCI believes that patients with tumors having low PD-L1 would be more likely to respond to Multikine because their tumors have lower defenses against the patient’s immune system. CEL-SCI estimates that patients with tumors having low PD-L1 represent about 70% of locally advanced primary SCCHN patients.
Targeting low PD-L1 also differentiates Multikine from other immunotherapies. For example, checkpoint inhibitors like Keytruda and Opdivo appear to best serve patients having high PD-L1, because these drugs work by blocking PD1/PD-L1 receptors interaction; when this interaction (PD1/PD-L1) happens it leads to inactivation/death of the immune cells attacking the tumor. These checkpoint inhibitors appear to act best when tumors express high levels of PD-L1 receptors (usually TPS >20 to TPS >50). While none of these drugs are currently approved as a first-line treatment before surgery, even if such approvals were to come in the future, we believe the large majority of patients in this group having low PD-L1 would still be expected to need Multikine.
CEL-SCI believes Multikine leads to longer survival with no safety issues. Clinical investigations of Multikine, presented at ESMO (Europe Society for Medical Oncology) in October 2023, have demonstrated in the randomized controlled Phase III trial (RCT) the following in the target population:
| · | risk of death cut in half at five years versus the control; |
| · | 28.6% absolute 5-year overall survival benefit versus control (p=0.0015); |
| · | 0.349 hazard ratio vs control (95% CIs [0.18, 0.66], Wald p=0.0012); |
| · | >35% rate of pre-surgery reductions and/or downstages (p<0.01); and |
| · | low PD-L1 tumor expression (vs high PD-L1 where Keytruda and Opdivo work best). |
There were no demonstrable safety signals or toxicities observed in approximately 740 Multikine-treated subjects across multiple clinical trials. Adverse event (AE) and serious adverse event (SAE) incidences were not significantly different among treatment and control groups. There were no Multikine-related deaths, no Multikine-related delays of surgery, no Multikine-related interference with post-surgical treatment, and only two discontinuations. Multikine-related AEs before surgery were local and resolved after surgery. Although the literature reports that some of Multikine’s components may be toxic when administered systemically (e.g., TNFα, IFN γ, IL-1β), these toxicities did not emerge with Multikine, even at doses many times higher than those administered in the Phase III trial, primarily due to Multikine’s delivery by local injection and dosage.
CEL-SCI published its data as abstracts and posters at the annual conferences for the 2022 American Society of Clinical Oncology (ASCO), 2022 and 2023 European Society for Medical Oncology (ESMO), and the 2023 European Head and Neck Society’s (EHNS’s) annual European Conference On Head And Neck Oncology (ECHNO) and the 2023 European Society for Therapeutic Radiology and Oncology (ESTRO) and 2023 American Head and Neck Society (AHNS). These publications can be accessed at http://www.cel-sci.com.
Multikine works by inducing pre-surgical responses. CEL-SCI observed statistically significant pre-surgical responses after Multikine treatment, and therefore CEL-SCI believes in the following:
| ➢ | Multikine causes pre-surgical responses; |
| ➢ | Pre-surgical responses lead to longer life; |
| ➢ | Therefore, selecting more patients predicted to have a pre-surgical response should lead to much better survival in the target population. |
A “pre-surgical response” is a significant change in disease before surgery. CEL-SCI saw two kinds of responses in the Phase III trial. First, there were “reductions” in the size of the tumor—a reduction of 30% or more qualified as a “pre-surgical reduction,” or “PSR” for short. Second, there were disease “downstages” (e.g., the disease improved from Stage IV to Stage III) pre-surgery. CEL-SCI calls this a “pre-surgical downstaging” or “PSD” for short. CEL-SCI’s 2022 ESMO cancer conference presentation reported on PSR, and CEL-SCI’s new 2023 ESMO presentation reported on PSD.
Across the whole Phase III trial, PSRs were seen in 8.5% of Multikine patients compared to none in the control group. PSDs were seen in 22% of Multikine patients as compared to 13% in the control group. Because Multikine was the only therapy given to these patients before surgery, it is CEL-SCI’s strong belief that Multikine had to be the cause of the higher rates of PSR and PSD. These data are presented visually below. The taller blue columns show PSR and PSD rates in all 529 Multikine-treated patients in the Phase III trial, and the gray columns show PSR and PSD rates for all 394 control patients.
![cvm_10qimg8.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg8.jpg)
It was not enough for us to show that Multikine likely leads to PSRs and PSDs as compared to a control group, CEL-SCI also had to test if PSRs and PSDs lead to improved survival. CEL-SCI’s Phase III trial demonstrated that PSR patients were 72% likely to be alive after five years, whereas control patients were only about 49% likely to be alive after five years. Patients with PSD saw similar improvement in CEL-SCI’s Phase III trial. Their five-year chance of survival was approximately 68%. Therefore, CEL-SCI believes that the Phase III trial demonstrated that those patients who had PSR or PSD resulting from Multikine lived longer than those who were not treated with Multikine. It is important to note that these results are from the entire Phase III study population, not from a subgroup. The likelihood of living at least five years is shown in the graphic below for patients with PSR (blue), patients with PSD (orange) and control patients who did not receive Multikine (gray).
![cvm_10qimg9.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg9.jpg)
Multikine cut the 5-year risk of death in half in the target population. CEL-SCI’s results show that Multikine can cut the risk of death in half at five years versus the control group in the target population. Survival increased from 45% in the control group to 73% in the Multikine group, at five years. This means the risk of death fell to 27% in the Multikine group from 55% in the control, shown below.
![cvm_10qimg10.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg10.jpg)
Another way to see the survival benefit of Multikine in the target population is the Kaplan-Meier curve from our ESMO ’23 poster, shown below. On the vertical axis is the probability of survival and the horizontal axis is time in months. The blue Multikine line is far above the green control line, meaning the chance of survival is much higher in the Multikine group at every point in time compared to the control. These results had a low (log rank) p-value of 0.0015, which is very significant as a statistical matter.
![cvm_10qimg11.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg11.jpg)
CEL-SCI’s physician consultants tell CEL-SCI that the early separation of these two survival curves (e.g., at 12 months) adds validation to the potential positive effects of Multikine.
Another measure of survival benefit is called the “hazard ratio,” which compares the rate of an event (chances) of dying between two different groups. Here, in the Multikine target population, the hazard ratio was 0.35, which means that deaths occurred in the Multikine group about one-third as frequently as in the control group. It is also important to note that the hazard ratio’s 95% confidence interval remained far below 1.0 (which would mean parity between the compared groups). In the case of Multikine, statistically speaking, there is a 95% chance that the hazard ratio would fall between 0.18 and 0.66 if Multikine were tested in the target population in another study. A hazard ratio of 0.66 as the “so called worst case scenario” (the upper limit of the 95% confidence interval - for the hazard ration - in this case) is still below (better) than the hazard ratio required for most drug approvals.
CEL-SCI completed a bias analysis for the target population in the Phase III study in preparation for submission of data to regulatory agencies including the FDA for confirmatory registration study. The detailed data on parameters including patient age, sex, race, tumor locations, and staging demonstrate balance between the treatment and control arms. Therefore, no bias was found, which supports confidence in Multikine’s efficacy results.
![cvm_10qimg15.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg15.jpg)
These positive survival outcomes—increased overall survival, reduced risk of death, widely separated Kaplan-Meier curves with early separation, low hazard ratio, low p-values, low confidence intervals—CEL-SCI believes were driven by high PSR/PSD rates in the target population, as shown in the graphic below:
![cvm_10qimg12.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg12.jpg)
CEL-SCI relies on all of these data together to support its plan to request accelerated/conditional approval in the new target population without waiting until the completion of another clinical trial. CEL-SCI’s regulatory strategy going forward is to seek approval of Multikine following full enrollment of our confirmatory study wherever possible.
CEL-SCI applied to the FDA for a 212-patient randomized controlled confirmatory registration study focusing only on those patients in the target population, this accounts for approximately 100,000 patients worldwide per year. In May 2024, CEL-SCI announced that the FDA indicated CEL-SCI may move forward with a confirmatory registration study of Multikine in the target population.
![cvm_10qimg13.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg13.jpg)
| · | The confirmatory study will be a randomized controlled trial with two arms: Multikine treatment plus standard of care versus standard of care alone. CEL-SCI expects to commence enrollment in Q4 2024 / Q1 2025 and reach full enrollment in Q2 2026. |
| | |
| · | If approved as a pre-surgical treatment, CEL-SCI believes Multikine should be added to the standard of care for the target population in this unmet medical need. |
| | |
| · | CEL-SCI believes that the confirmatory study has a high likelihood of success based on the large survival benefit that has already been observed in the target population from the completed Phase III study. The planned confirmatory study will be much smaller—less than a quarter the size of the prior study— and will focus on the patients who saw the greatest survival benefit when treated with Multikine. |
Why Do We Believe Our Confirmatory Study Will Be Successful?
![cvm_10qimg14.jpg](https://www.sec.gov/Archives/edgar/data/725363/000165495424010651/cvm_10qimg14.jpg)
An “unmet need” is a factor for approval considered by all major regulatory bodies worldwide. In the Multikine target population, there is also a great unmet need for improved survival. The current standard of care provides only about a 50/50 chance of surviving five years, whereas Multikine could increase that survival rate to over 70% in the target population based on the Phase III data. Chemotherapy (in addition to radiotherapy following surgery) has improved survival outcome for some head and neck patients, but chemotherapy is only indicated for high-risk patients, who are not likely to fall within the Multikine target population. Currently available immunotherapies are given after surgery or where surgery is not indicated, in contrast to Multikine, which is given before surgery to patients with resectable tumors. Available checkpoint inhibitors work best on tumors with high PD-L1 expression, whereas Multikine works best in tumors with low PD-L1 expression. Therefore, Multikine’s target population is underserved, and will continue to be underserved, by current therapies, but Multikine can meet the need for improved survival.
The major regulatory bodies with whom we are working, U.S. FDA, Health Canada, European Medicines Agency (EMA) and the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom (UK) all have conditional approval pathways designed for situations where the target population has not been fully tested prospectively and there is strong data supporting clinical benefit for patients. The reason is that regulators understand that in many cases patients should not have to wait for additional data before being offered the chance to benefit from a new drug, especially if the drug has shown to be safe. Every situation is different and depends on the specific facts.
IN CONCLUSION
| · | Strong survival data: Multikine-treated patients in the target population had a 73% 5-year survival vs a 45% 5-year survival in the control group who did not receive Multikine in the Phase III study. In addition, no safety signals or toxicities versus standard of care. The Hazard ratio is 0.35 with an upper limit of 0.66. |
| | |
| · | Addressing an unmet medical need: Multikine focuses on the 70% of patients not well served by the two leading approved drugs for head and neck cancer, Keytruda and Opdivo. Multikine’s proposed indication is a pre-surgical treatment in head & neck cancer, where no drug is currently approved. |
| | |
| · | Multikine’s Target Population: The confirmatory registration study will focus on newly diagnosed locally advanced primary head and neck cancer patients with no lymph node involvement (determined via PET scan) and with low PD-L1 tumor expression (determined via biopsy). |
| | |
| · | FDA pathway: CEL-SCI is aiming to begin enrollment for a 212-patient confirmatory registration study in Q4 2024 / Q1 2025 with full enrollment expected about Q2 2026. Potential to seek early approval after full enrollment. |
Liquidity and Capital Resources
Since inception, the Company has financed its operations through the issuance of equity securities, convertible notes, loans and certain research grants. The Company will likely continue to generate net operating losses as it continues the development of Multikine and brings other drug candidates into clinical trials. Until such time as the Company becomes profitable, any or all of these financing vehicles or others may be utilized to assist the Company’s capital requirements.
Capital raised by the Company has been expended primarily for patent applications, research and development, administrative costs, the construction and upgrade of the Company’s manufacturing and laboratory facilities and clinical trials. The Company does not anticipate realizing significant revenues until entering into licensing arrangements for its technology and know-how or until it receives regulatory approval to sell its products (which could take several years). Thus, the Company has been dependent upon the proceeds from the sale of its securities to meet all of the Company’s liquidity and capital requirements and anticipates having to do so in the future.
The cost of the confirmatory registration study is estimated to be about $30 million. The Company will be required to raise additional capital or find additional long-term financing to continue with its research efforts. The ability to raise capital may be dependent upon market conditions that are outside the control of the Company. The ability of the Company to complete the necessary clinical trials and obtain FDA approval for the sale of products to be developed on a commercial basis is uncertain. Ultimately, the Company must complete the development of its products, obtain the appropriate regulatory approvals and obtain sufficient revenues to support its cost structure. However, there can be no assurance that the Company will be able to raise sufficient capital to support its operations. Due to recurring losses from operations and future liquidity needs, there is substantial doubt about the Company’s ability to continue as a going concern.
Under a co-development agreement, Ergomed agreed to contribute up to $12 million towards the completed Phase 3 study where it performed clinical services in exchange for a single digit percentage of milestone and royalty payments, up to a specified maximum amount. Approximately $11.9 million of the committed $12 million contribution has been realized as of June 30, 2024.
During the nine months ended June 30, 2024, the Company’s cash decreased by approximately $3.8 million. Significant components of this decrease included cash used to fund the Company’s regular operations of approximately $13.9 million and approximately $1.3 million in payments on finance lease obligations offset by net proceeds from the November 2023 and February 2024 financing of $11.4 million.
During the nine months ended June 30 , 2023, the Company’s cash decreased by approximately $17.5 million. The significant component of this decrease included cash used to fund the Company’s regular operations of approximately $17.8 million, which includes the approximate $2.3 million deposit made to the Company’s landlord as a result of falling below certain cash requirements per the San Tomas lease. Other components of this decrease include approximately $0.4 million used to make leasehold improvements and acquire research and development equipment, and approximately $1.2 million in payments on the Company’s finance leases.
During the nine months ended June 30, 2024, no warrants were exercised. During the nine months ended June 30 , 2023, 217,752 warrants were exercised at a weighted average exercise price of $2.05 for total proceeds of approximately $0.5 million.
Results of Operations and Financial Condition
The Company incurred a net operating loss of approximately $20.2 million for the nine months ended June 30, 2024. This net operating loss consists of significant non-cash expenses including approximately $4.1 million in share-based compensation to employees and non-employees, and approximately $3.0 million in depreciation and amortization expense. The Company incurred a net operating loss of approximately $6.7 million for the three months ended June 30, 2024. This net operating loss consists of significant non-cash expenses including approximately $1.0 million in share-based compensation to employees and non-employees, and approximately $1.0 million in depreciation and amortization expense.
During the nine months ended June 30, 2024, research and development expenses decreased by approximately $3.5 million, or 20%, compared to the nine months ended June 30 , 2023. Major components of this decrease include an approximately $2.4 million decrease in expenses related to the Phase 3 study, a decrease of approximately $1.1 million of employee stock compensation expense and an approximately $0.1 million decrease in other research and development costs which is offset by $0.1 million increase in costs incurred to prepare for the potential commercial sale of Multikine.
During the three months ended June 30, 2024, research and development expenses decreased by approximately $1.0 million, or 18%, compared to the three months ended June 30 , 2023. Major components of this decrease include an approximately $0.9 million decrease in expenses related to the Phase 3 study, a decrease of approximately $0.5 million of employee stock compensation expense which is offset by $0.4 million increase in costs incurred to prepare for the confirmatory Registration Study and potential commercial sale of Multikine.
During the nine months ended June 30, 2024, general and administrative expenses decreased by approximately $0.3 million, or 4%, compared to the nine months ended June 30 , 2023. This decrease is primarily due to an approximately $0.5 million decrease in consulting fees and a decrease of approximately $0.4 million of employee stock compensation expense, which is offset by increase of approximately $0.6 million in other general and administrative costs.
During the three months ended June 30, 2024, general and administrative expenses decreased by approximately $0.5 million, or 20%, compared to the three months ended June 30 , 2023. This decrease is primarily due to an approximately $0.3 million decrease in consulting fees, an decrease of approximately $0.4 million of employee stock compensation expense which is offset by net increase of approximately $0.2 million in other general and administrative expenses.
During the nine months ended June 30, 2024, net interest expense increased by approximately $0.1 million compared to the nine months ended June 30, 2023. While the amount of interest paid on the Company’s lease liabilities are approximately $0.7 million and $0.8 million for the nine months ended June 30, 2024 and 2023, the Company earned approximately $0.2 million less in interest income during the nine months ended June 30, 2024 compared to the nine months ended June 30, 2023. Net interest expense, which consists primarily of interest paid on lease liabilities, are approximately $0.2 for both the three months ended June 30, 2024 and June 30 , 2023.
Research and Development Expenses
The Company’s research and development efforts involve Multikine and LEAPS. The table below shows the research and development expenses associated with each project.
| | Nine months ended, | | | Three months ended, | |
| | June 30, | | | June 30, | |
| | 2024 | | | 2023 | | | 2024 | | | 2023 | |
MULTIKINE | | $ | 13,615,922 | | | $ | 16,919,843 | | | $ | 4,681,127 | | | $ | 5,661,214 | |
LEAPS | | | 68,282 | | | | 283,980 | | | | 22,033 | | | | 66,575 | |
TOTAL | | $ | 13,684,204 | | | $ | 17,203,823 | | | $ | 4,703,160 | | | $ | 5,727,789 | |
Clinical and other studies necessary to obtain regulatory approval of a new drug involve significant costs and require several years to complete. The extent of the Company’s clinical trials and research programs are primarily based upon the amount of capital available to the Company and the extent to which the Company has received regulatory approvals for clinical trials. The inability of the Company to conduct clinical trials or research, whether due to a lack of capital or regulatory approval, will prevent the Company from completing the studies and research required to obtain regulatory approval for any products which the Company is developing. Without regulatory approval, the Company will be unable to sell any of its products. Since all of the Company’s projects are under development, the Company cannot predict when it will be able to generate any revenue from the sale of any of its products.
Critical Accounting Estimates
Management’s discussion and analysis of the Company’s financial condition and results of operations is based on its unaudited condensed financial statements. The preparation of these financial statements is based on the selection of accounting policies and the application of significant accounting estimates, some of which require management to make judgments, estimates and assumptions that affect the amounts reported in the financial statements and notes.
The Company believes some of the more critical estimates that affect its financial condition and results of operations are in the areas of leases and share-based compensation.
The measurement of the finance and operating lease right-of-use asset and lease liabilities requires the determination of an estimated lease term and an incremental borrowing rate, which involves complex judgment by management. Significant judgment is required by management to develop inputs and assumptions used to determine the incremental borrowing rate for lease contracts. The fair value of the stock options is calculated using the Black-Scholes option pricing model which requires various judgmental assumptions including volatility and expected option life. The compensation cost is recognized as expense over the requisite service or vesting period. Performance-based options are valued using a Monte-Carlo simulation model, which requires inputs based on estimates, including the likelihood of the occurrence of performance and market conditions, volatility and expected option life.
For more information regarding the Company’s critical accounting estimates, see Part II, Item 7 of the Company’s Annual Report on Form 10-K for the year ended September 30, 2023. The application of these critical accounting estimates has been discussed with the Audit Committee of the Company’s Board of Directors.
Item 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISKS
The Company does not believe that it has any significant exposure to market risk.
Item 4. CONTROLS AND PROCEDURES
Evaluation of Disclosure Controls and Procedures
Under the direction and with the participation of the Company’s management, including the Company’s Chief Executive Officer and Chief Financial Officer, the Company carried out an evaluation of the effectiveness of the design and operation of its disclosure controls and procedures as of June 30, 2024. The Company maintains disclosure controls and procedures that are designed to ensure that information required to be disclosed in its periodic reports with the Securities and Exchange Commission is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and regulations, and that such information is accumulated and communicated to the Company’s management, including its principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure. The Company’s disclosure controls and procedures are designed to provide a reasonable level of assurance of reaching its desired disclosure control objectives.
The Company’s Chief Executive Officer and Chief Financial Officer has concluded that the Company’s disclosure controls and procedures were not effective as of June 30, 2024 due to the material weaknesses described in the Company's Annual Report on Form 10-K for the year ended September 30, 2023.
Changes in Internal Control over Financial Reporting
There were no changes in the Company’s internal control over financial reporting that occurred during the three months ended June 30, 2024 that have materially affected, or are reasonably likely to materially affect, the Company’s internal control over financial reporting.
PART II
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
During the nine months ended June 30, 2024, the Company issued 321,761 restricted shares of common stock to consultants for investor relations services and clinical drug and corporate development.
The Company relied upon the exemption provided by Section 4(a)(2) of the Securities Act of 1933 with respect to the issuance of these shares. The individuals who acquired these shares were sophisticated investors and were provided full information regarding the Company’s business and operations. There was no general solicitation in connection with the offer or sale of these securities. The individuals who acquired these shares acquired them for their own accounts. The certificates representing these shares bear a restricted legend which provides they cannot be sold except pursuant to an effective registration statement or an exemption from registration. No commission or other form of remuneration was given to any person in connection with the issuance of these shares.
Item 5. Other Information
None of our directors or officers adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement (as defined in Item 408(c) of Regulation S-K) during the quarterly period ending June 30, 2024.
Item 6. Exhibits
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
| CEL-SCI CORPORATION | |
| | | |
Date: August 14, 2024 | By: | /s/ Geert Kersten | |
| | Geert Kersten | |
| | Principal Executive Officer* | |
* Also signing in the capacity of the Principal Accounting and Financial Officer.
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v3.24.2.u1
CONDENSED BALANCE SHEETS - USD ($)
|
Jun. 30, 2024 |
Sep. 30, 2023 |
Current assets: |
|
|
Cash and cash equivalents |
$ 384,652
|
$ 4,145,735
|
Prepaid expenses |
551,337
|
520,368
|
Supplie used for R&D and manufacturing |
2,555,249
|
2,248,072
|
Deposits current |
51,129
|
4,245
|
Total current assets |
3,542,367
|
6,918,420
|
Finance lease right of use assets |
7,800,909
|
9,131,987
|
Operating lease right of use assets |
1,548,010
|
1,698,243
|
Property and equipment, net |
8,613,316
|
10,188,126
|
Patent costs, net |
173,028
|
197,704
|
Deposits |
2,319,101
|
2,319,101
|
Supplies used for R&D and manufacturing |
71,589
|
74,669
|
Total assets |
24,068,320
|
30,528,250
|
Current liabilities: |
|
|
Accounts payable |
1,369,441
|
2,009,786
|
Accrued expenses |
1,272,149
|
1,049,581
|
Due to employees |
696,487
|
557,244
|
Finance lease obligation, current portion |
1,949,245
|
1,771,804
|
Operating lease obligation, current portion |
219,019
|
197,431
|
Total current liabilities |
5,506,341
|
5,585,846
|
Finance lease obligations, net of current portion |
8,477,784
|
9,949,565
|
Operating lease obligations, net of current portion |
1,486,138
|
1,652,949
|
Other liabilities |
125,000
|
125,000
|
Total liabilities |
15,595,263
|
17,313,360
|
STOCKHOLDERS' EQUITY |
|
|
Preferred stock, $.01 par value; 200,000 shares authorized; 0 shares issued and outstanding |
0
|
0
|
Common stock, $.01 par value; 600,000,000 shares authorized; 54,257,884 and 47,422,304 shares issued and outstanding at June 30, 2024 and September 30, 2023, respectively |
542,578
|
474,223
|
Additional paid-in capital |
515,832,848
|
499,832,063
|
Accumulated deficit |
(507,902,369)
|
(487,091,396)
|
Total stockholders' equity |
8,473,057
|
13,214,890
|
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY |
$ 24,068,320
|
$ 30,528,250
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v3.24.2.u1
CONDENSED BALANCE SHEETS (Parenthetical) - $ / shares
|
Jun. 30, 2024 |
Sep. 30, 2023 |
CONDENSED BALANCE SHEETS |
|
|
Preferred stock, par value |
$ 0.01
|
$ 0.01
|
Preferred stock, shares authorized |
200,000
|
200,000
|
Preferred stock, shares issued |
0
|
0
|
Preferred stock, shares outstanding |
0
|
0
|
Common stock, par value |
$ 0.01
|
$ 0.01
|
Common stock, shares authorized |
600,000,000
|
600,000,000
|
Common stock, shares issued |
54,257,884
|
47,422,304
|
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54,257,884
|
47,422,304
|
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- DefinitionFace amount or stated value per share of common stock.
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v3.24.2.u1
CONDENSED STATEMENTS OF OPERATIONS (UNAUDITED) - USD ($)
|
3 Months Ended |
9 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Operating expenses: |
|
|
|
|
Research and development |
$ 4,703,160
|
$ 5,727,789
|
$ 13,684,204
|
$ 17,203,823
|
General and administrative |
1,967,075
|
2,453,968
|
6,547,866
|
6,804,729
|
Total operating expenses |
6,670,235
|
8,181,757
|
20,232,070
|
24,008,552
|
Operating loss |
(6,670,235)
|
(8,181,757)
|
(20,232,070)
|
(24,008,552)
|
Interest expense, net |
(190,705)
|
(181,670)
|
(571,102)
|
(493,522)
|
Other expense |
(4,382)
|
(3,854)
|
(7,801)
|
(61,525)
|
Net loss |
(6,856,558)
|
(8,367,281)
|
(20,810,973)
|
(24,563,599)
|
Modification of warrants |
(659,456)
|
0
|
(659,456)
|
(171,552)
|
Net loss available to common shareholders |
$ (7,516,014)
|
$ (8,367,281)
|
$ (21,470,429)
|
$ (24,735,151)
|
Net loss per common share - basic and diluted |
$ (0.14)
|
$ (0.19)
|
$ (0.42)
|
$ (0.57)
|
Weighted average common shares outstanding - basic and diluted |
53,994,384
|
44,254,363
|
51,479,454
|
43,761,395
|
X |
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v3.24.2.u1
STATEMENTS OF STOCKHOLDERS EQUITY (UNAUDITED) - USD ($)
|
Total |
Common Stock |
Additional Paid-In Capital |
Retained Earnings (Accumulated Deficit) |
Balance, shares at Sep. 30, 2022 |
|
43,448,317
|
|
|
Balance, amount at Sep. 30, 2022 |
$ 32,163,207
|
$ 434,484
|
$ 486,625,816
|
$ (454,897,093)
|
Warrant exercises shares |
|
217,752
|
|
|
Warrant exercises amount |
447,291
|
$ 2,177
|
445,114
|
0
|
Equity based compensation - employees |
1,703,931
|
$ 0
|
1,703,931
|
0
|
401(k) contributions paid in common stock shares |
|
21,331
|
|
|
401(k) contributions paid in common stock amount |
50,178
|
$ 213
|
49,965
|
0
|
Stock issued to nonemployees for service shares |
|
40,236
|
|
|
Stock issued to nonemployees for service amount |
91,623
|
$ 402
|
91,221
|
0
|
2014 incentive stock forfeited shares |
|
(2,000)
|
|
|
2014 incentive stock forfeited amount |
(11,100)
|
$ (20)
|
(11,080)
|
0
|
Net Income (Loss) |
(7,853,509)
|
$ 0
|
0
|
(7,853,509)
|
Balance, shares at Dec. 31, 2022 |
|
43,725,636
|
|
|
Balance, amount at Dec. 31, 2022 |
26,591,621
|
$ 437,256
|
488,904,967
|
(462,750,602)
|
Balance, shares at Sep. 30, 2022 |
|
43,448,317
|
|
|
Balance, amount at Sep. 30, 2022 |
32,163,207
|
$ 434,484
|
486,625,816
|
(454,897,093)
|
Net Income (Loss) |
(24,563,599)
|
|
|
|
Balance, shares at Jun. 30, 2023 |
|
44,748,437
|
|
|
Balance, amount at Jun. 30, 2023 |
14,789,399
|
$ 447,484
|
493,802,607
|
(479,460,692)
|
Balance, shares at Dec. 31, 2022 |
|
43,725,636
|
|
|
Balance, amount at Dec. 31, 2022 |
26,591,621
|
$ 437,256
|
488,904,967
|
(462,750,602)
|
Equity based compensation - employees |
1,743,288
|
$ 0
|
1,743,288
|
0
|
401(k) contributions paid in common stock shares |
|
23,627
|
|
|
401(k) contributions paid in common stock amount |
54,865
|
$ 236
|
54,629
|
0
|
Stock issued to nonemployees for service shares |
|
38,562
|
|
|
Stock issued to nonemployees for service amount |
100,635
|
$ 386
|
100,249
|
0
|
Net Income (Loss) |
(8,342,809)
|
$ 0
|
0
|
(8,342,809)
|
Balance, shares at Mar. 31, 2023 |
|
43,787,825
|
|
|
Balance, amount at Mar. 31, 2023 |
20,147,600
|
$ 437,878
|
490,803,133
|
(471,093,411)
|
Equity based compensation - employees |
1,551,319
|
$ 0
|
1,551,319
|
0
|
401(k) contributions paid in common stock shares |
|
12,855
|
|
|
401(k) contributions paid in common stock amount |
52,663
|
$ 129
|
52,534
|
0
|
Stock issued to nonemployees for service shares |
|
36,523
|
|
|
Stock issued to nonemployees for service amount |
135,669
|
$ 365
|
135,304
|
0
|
2014 incentive stock forfeited shares |
|
(2,000)
|
|
|
2014 incentive stock forfeited amount |
(11,100)
|
$ (20)
|
(11,080)
|
0
|
Net Income (Loss) |
(8,367,281)
|
$ 0
|
0
|
(8,367,281)
|
Proceeds from the sale of common stock shares |
|
913,234
|
|
|
Proceeds from the sale of common stock amount |
1,552,497
|
$ 9,132
|
1,543,365
|
0
|
Share issuance costs |
(271,968)
|
$ 0
|
(271,968)
|
0
|
Balance, shares at Jun. 30, 2023 |
|
44,748,437
|
|
|
Balance, amount at Jun. 30, 2023 |
14,789,399
|
$ 447,484
|
493,802,607
|
(479,460,692)
|
Balance, shares at Sep. 30, 2023 |
|
47,422,304
|
|
|
Balance, amount at Sep. 30, 2023 |
13,214,890
|
$ 474,223
|
499,832,063
|
(487,091,396)
|
Equity based compensation - employees |
1,383,909
|
$ 0
|
1,383,909
|
0
|
401(k) contributions paid in common stock shares |
|
17,724
|
|
|
401(k) contributions paid in common stock amount |
48,907
|
$ 177
|
48,730
|
0
|
Stock issued to nonemployees for service shares |
|
88,573
|
|
|
Stock issued to nonemployees for service amount |
202,307
|
$ 886
|
201,421
|
0
|
Net Income (Loss) |
(6,709,524)
|
$ 0
|
0
|
(6,709,524)
|
Proceeds from the sale of common stock shares |
|
2,490,000
|
|
|
Proceeds from the sale of common stock amount |
4,980,000
|
$ 24,900
|
4,955,100
|
0
|
Share issuance costs |
(470,229)
|
$ 0
|
(470,229)
|
0
|
Balance, shares at Dec. 31, 2023 |
|
50,018,601
|
|
|
Balance, amount at Dec. 31, 2023 |
12,650,260
|
$ 500,186
|
505,950,994
|
(493,800,920)
|
Balance, shares at Sep. 30, 2023 |
|
47,422,304
|
|
|
Balance, amount at Sep. 30, 2023 |
13,214,890
|
$ 474,223
|
499,832,063
|
(487,091,396)
|
Net Income (Loss) |
(20,810,973)
|
|
|
|
Balance, shares at Jun. 30, 2024 |
|
54,257,884
|
|
|
Balance, amount at Jun. 30, 2024 |
8,473,057
|
$ 542,578
|
515,832,848
|
(507,902,369)
|
Balance, shares at Dec. 31, 2023 |
|
50,018,601
|
|
|
Balance, amount at Dec. 31, 2023 |
12,650,260
|
$ 500,186
|
505,950,994
|
(493,800,920)
|
Equity based compensation - employees |
1,432,540
|
$ 0
|
1,432,540
|
0
|
401(k) contributions paid in common stock shares |
|
27,373
|
|
|
401(k) contributions paid in common stock amount |
53,485
|
$ 274
|
53,211
|
0
|
Stock issued to nonemployees for service shares |
|
162,744
|
|
|
Stock issued to nonemployees for service amount |
380,870
|
$ 1,627
|
379,243
|
0
|
Net Income (Loss) |
(7,244,891)
|
$ 0
|
0
|
(7,244,891)
|
Proceeds from the sale of common stock shares |
|
3,875,000
|
|
|
Proceeds from the sale of common stock amount |
7,750,000
|
$ 38,750
|
7,711,250
|
0
|
Share issuance costs |
(717,621)
|
$ 0
|
(717,621)
|
0
|
Balance, shares at Mar. 31, 2024 |
|
54,083,718
|
|
|
Balance, amount at Mar. 31, 2024 |
14,304,643
|
$ 540,837
|
514,809,617
|
(501,045,811)
|
Equity based compensation - employees |
728,120
|
$ 0
|
728,120
|
0
|
401(k) contributions paid in common stock shares |
|
45,722
|
|
|
401(k) contributions paid in common stock amount |
60,577
|
$ 457
|
60,120
|
0
|
Stock issued to nonemployees for service shares |
|
70,444
|
|
|
Stock issued to nonemployees for service amount |
155,655
|
$ 704
|
154,951
|
0
|
Net Income (Loss) |
(6,856,558)
|
$ 0
|
0
|
(6,856,558)
|
Purchase of stock by officers and directors sahres |
|
58,000
|
|
|
Purchase of stock by officers and directors amount |
80,620
|
$ 580
|
80,040
|
0
|
Balance, shares at Jun. 30, 2024 |
|
54,257,884
|
|
|
Balance, amount at Jun. 30, 2024 |
$ 8,473,057
|
$ 542,578
|
$ 515,832,848
|
$ (507,902,369)
|
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v3.24.2.u1
CONDENSED STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($)
|
9 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
CONDENSED STATEMENTS OF CASH FLOWS (UNAUDITED) |
|
|
Net loss |
$ (20,810,973)
|
$ (24,563,599)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Depreciation and amortization |
2,977,603
|
2,959,681
|
Non-cash lease expense |
5,008
|
12,788
|
Share-based payments for services |
778,571
|
473,723
|
Equity-based compensation |
3,544,569
|
4,976,338
|
Common stock contributed to 401(k) plan (Increase)/decrease in assets: |
162,969
|
157,706
|
Prepaid expenses |
(15,708)
|
208,419
|
Supplies used for R&D and manufacturing |
(304,097)
|
(24,491)
|
Deposits |
(46,884)
|
(2,342,951)
|
Increase/(decrease) in liabilities: |
|
|
Accounts payable |
(592,370)
|
66,616
|
Accrued expenses |
167,568
|
243,800
|
Due to employees |
139,243
|
28,173
|
Net cash used in operating activities |
(13,994,502)
|
(17,803,797)
|
CASH FLOWS FROM INVESTING ACTIVITIES: |
|
|
Purchases of property and equipment |
(75,122)
|
(361,892)
|
Expenditures for patent costs |
(13,211)
|
0
|
Net cash used in investing activities |
(88,333)
|
(361,892)
|
CASH FLOWS FROM FINANCING ACTIVITIES: |
|
|
Proceeds from issuance of common stock |
12,730,000
|
1,552,497
|
Payments of stock issuance costs |
(1,173,577)
|
(213,796)
|
Proceeds from the purchase of stock by officers and directors |
80,620
|
0
|
Proceeds from the exercise of warrants |
0
|
447,291
|
Payments on obligations under finance leases |
(1,315,291)
|
(1,157,371)
|
Net cash provided by financing activities |
10,321,752
|
628,621
|
NET DECREASE IN CASH AND CASH EQUIVALENTS |
(3,761,083)
|
(17,537,068)
|
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD |
4,145,735
|
22,672,138
|
CASH AND CASH EQUIVALENTS, END OF PERIOD |
384,652
|
5,135,070
|
SUPPLEMENTAL SCHEDULE OF NON-CASH INVESTING AND FINANCING ACTIVITIES: |
|
|
Assets purchased under finance leases |
20,797
|
0
|
Finance lease obligation included in accounts payable |
1,296
|
927
|
Property and equipment included in current liabilities |
2,770
|
0
|
Consulting services paid with issuance of common stock |
738,832
|
327,927
|
Accrued consulting services to be paid with common stock |
110,000
|
110,000
|
Financing costs included in current liabilities |
91,975
|
58,172
|
Cash paid for interest |
$ 706,517
|
$ 809,495
|
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v3.24.2.u1
BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
|
9 Months Ended |
Jun. 30, 2024 |
BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES |
|
BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES |
A. BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Basis of Presentation The accompanying condensed financial statements of CEL-SCI Corporation (the “Company”) are unaudited and certain information and footnote disclosures normally included in the annual financial statements prepared in accordance with accounting principles generally accepted in the United States of America have been omitted pursuant to the rules and regulations of the Securities and Exchange Commission. While management of the Company believes that the disclosures presented are adequate to make the information presented not misleading, these interim condensed financial statements should be read in conjunction with the financial statements and notes included in the Company’s annual report on Form 10-K for the year ended September 30, 2023. In the opinion of management, the accompanying unaudited condensed financial statements contain all adjustments (all of which are of a normal recurring nature) and disclosures necessary for a fair presentation of the Company’s financial position as of June 30, 2024 and the results of its operations for the nine months then ended. The condensed balance sheet as of September 30, 2023 is derived from the September 30, 2023 audited financial statements. Due to recurring losses from operations and future liquidity needs, there is substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of this uncertainty. Refer to discussion in Note B. Summary of Significant Accounting Policies: Cash and Cash Equivalents – Cash and cash equivalents consist principally of unrestricted cash on deposit and short-term money market funds. The Company considers all highly liquid investments with a maturity when purchased of less than three months to be cash equivalents. Property and Equipment – Property and equipment is recorded at cost and depreciated using the straight-line method over estimated useful lives of five to seven years. Leasehold improvements are depreciated over the shorter of the estimated useful life of the asset or the term of the lease. Repairs and maintenance which do not extend the life of the asset are expensed when incurred. Property and equipment is reviewed on a quarterly basis to determine if any of the assets are impaired. Supplies used for R&D and manufacturing – Supplies are consumable items kept on hand to support the Company’s R&D and manufacturing operations. Supplies are recorded at cost and are charged to expense as they are used in operations. Patents – Patent expenditures are capitalized and amortized using the straight-line method over the shorter of the expected useful life or the legal life of the patent (17 years). In the event changes in technology or other circumstances impair the value or life of the patent, appropriate adjustments to the asset value and period of amortization are made. An impairment loss is recognized when estimated future undiscounted cash flows expected to result from the use of the asset, and from its disposition, are less than the carrying value of the asset. The amount of the impairment loss would be the difference between the estimated fair value of the asset and its carrying value. Leases – The Company accounts for contracts that convey the right to control the use of identified property, plant or equipment over a period of time in exchange for consideration as leases upon inception. The Company leases certain real estate, machinery, laboratory equipment and office equipment over varying periods. Many of these leases include an option to either renew or terminate the lease. For purposes of calculating lease liabilities, these options are included in the lease term when it is reasonably certain that the Company will exercise such options. The incremental borrowing rate utilized to calculate the lease liabilities is based on the information available at the commencement date, as most of the leases do not provide an implicit borrowing rate. Short-term leases, defined as leases with initial terms of 12 months or less, are not reflected on the balance sheet. Lease expense for such short-term leases is not material. Share-Based Compensation – Compensation cost for all share-based awards is measured at fair value as of the grant date in accordance with the provisions of ASC 718, Compensation – Stock Compensation (“ASC 718”). The fair value of stock options is calculated using the Black-Scholes option pricing model. The Black-Scholes model requires five input variables: the strike price of an option, the current stock price, the time to expiration, the risk-free rate, and the volatility. The share-based compensation cost is recognized using the straight-line method as expense over the requisite service or vesting period. The Company has Incentive Stock Option Plans, Non-Qualified Stock Option Plans, Stock Compensation Plans, Stock Bonus Plans and an Incentive Stock Bonus Plan. These Plans are collectively referred to as the “Plans”. All Plans have been approved by the Company’s stockholders. The Company’s stock options are not transferable, and the actual value of the stock options that an employee may realize, if any, will depend on the excess of the market price on the date of exercise over the exercise price. For options issued with service conditions only, the Company has based its assumption for stock price volatility on the variance of daily closing prices of the Company’s stock. The risk-free interest rate assumption is based on the U.S. Treasury rate at the date of grant with the term equal to the expected life of the option. Forfeitures are accounted for when they occur. The expected term of options represents the period that options granted are expected to be outstanding and has been determined based on an analysis of historical exercise behavior. If any of the assumptions used in the Black-Scholes model change significantly, share-based compensation expense for new awards may differ materially in the future from that recorded in the current period. Restricted stock granted under the Incentive Stock Bonus Plan and options granted under the Non-Qualified Stock Option Plans are subject to service, performance and market conditions and meet the classification of equity awards. These awards were measured at fair value on the grant dates using a Monte Carlo simulation for issuances where the attainment of performance criteria is uncertain. The total compensation cost will be expensed over the estimated requisite service period. Research and Development Costs – Research and development costs are expensed as incurred. Management accrues Clinical Research Organization (“CRO”) expenses and clinical trial study expenses based on services performed and relies on the CROs to provide estimates of those costs applicable to the completion stage of a study. Estimated accrued CRO costs are subject to revisions as such studies progress to completion. The Company records revisions to estimated expense in the period in which the facts that give rise to the revision become known. Net Loss Per Common Share – The Company calculates net loss per common share in accordance with ASC 260, Earnings Per Share. Basic and diluted net loss per common share was determined by dividing net loss applicable to common shareholders by the weighted average number of common shares outstanding during the period. The Company’s potentially dilutive shares, which include outstanding common stock options, unvested restricted stock and common stock warrants, have not been included in the computation of diluted net loss per share for all periods as the result would be anti-dilutive. Income Taxes – The Company accounts for income taxes in accordance with the provisions of ASC 740, Income Taxes, on a tax jurisdiction basis. Deferred tax assets and liabilities are recognized for future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases and operating and tax loss carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. The Company records a valuation allowance to reduce the deferred tax assets to the amount that is more likely than not to be recognized. A full valuation allowance was recorded against the deferred tax assets as of June 30, 2024 and September 30, 2023. Impairment of long-lived assets – CEL-SCI’s fixed assets are made up of leasehold improvements, furniture, and equipment. ASC 360-10 requires that a long-lived asset group be reviewed for impairment only when events or changes in circumstances indicate that the carrying amount of the long-lived asset (group) might not be recoverable. CEL-SCI’s recurring losses are a triggering event that could indicate impairment of long-lived assets such as fixed assets. CEL-SCI reviews these assets to determine if events or changes in circumstances indicate the existence of impairment. If indicators of impairment exist, the Company tests for recoverability, then, if necessary, measures and records the impairment. The amount of the impairment loss would be the amount by which the carrying amount of the asset (group) exceeds its fair value. Use of Estimates – The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and the accompanying disclosures. These estimates are based on management’s best knowledge of current events and actions the Company may undertake in the future. Estimates are used in accounting for, among other items, inventory obsolescence, accruals, stock options, useful lives for depreciation and amortization of long-lived assets, right of use assets and lease liabilities, deferred tax assets and the related valuation allowance. Actual results could differ from estimates, although management does not generally believe such differences would materially affect the financial statements in any given year. Additionally, in calculating the right of use assets and lease liabilities, estimates and assumptions were used to determine the incremental borrowing rates and the expected lease terms. The Company considers the estimates used in valuing the stock options and the lease assets and liabilities to be significant. Recently Adopted Accounting Standards In June 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update No. 2016-13, Financial Instruments – Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments (“ASU 2016-13”). ASU 2016-13 requires a financial asset (or a group of financial assets) measured at amortized cost basis to be presented at the net amount expected to be collected. The amendments in ASU 2016-13 replace the incurred loss impairment methodology in current U.S. GAAP with a methodology that reflects expected credit losses and requires consideration of a broader range of reasonable and supportable information. ASU 2016-13 was effective for SEC filers, excluding smaller reporting companies, for fiscal years beginning after December 15, 2019, including interim periods within those fiscal years. As a smaller reporting company, the Company was permitted to adopt the new standard for fiscal years beginning after December 15, 2022, including interim periods within those fiscal years. Effective October 1, 2023, the Company adopted ASU 2016-13 using a modified retrospective transition method. The adoption of ASU 2016-13 had no impact on the Company’s financial position, results of operations, or cash flows. New Accounting Pronouncements In November 2023, the FASB issued Accounting Standards Update No. 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures (“ASU 2023-07”), which expands disclosures about a public entity’s reportable segments and requires more enhanced information about a reportable segment’s expenses, interim segment profit or loss, and how a public entity’s chief operating decision maker uses reported segment profit or loss information in assessing segment performance and allocating resources. The update will be effective for annual periods beginning after December 15, 2023 and interim periods beginning after December 15, 2024. The Company is assessing the effect of this update on the condensed financial statement disclosures. In December 2023, the FASB issued Accounting Standards Update No. 2023-09, Improvements to Income Tax Disclosures, which require greater disaggregation of income tax disclosures related to the income tax rate reconciliation and income taxes paid. The update will be effective for annual periods beginning after December 15, 2024. The guidance should be applied on a prospective basis with the option to apply the standard retrospectively. Early adoption is permitted. The Company is currently evaluating the impact that this change will have on the Company's disclosures.
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v3.24.2.u1
LIQUIDITY
|
9 Months Ended |
Jun. 30, 2024 |
LIQUIDITY |
|
LIQUIDITY |
B. LIQUIDITY The Company has incurred significant costs since its inception for the acquisition of certain proprietary technology and scientific knowledge relating to the human immunological defense system, patent applications, research and development, administrative costs, construction and expansion of manufacturing and laboratory facilities and conducting clinical trials. The Company has funded such costs primarily with proceeds from loans and the public and private sale of its securities. The Company will be required to raise additional capital or find additional long-term financing to continue with its efforts to bring Multikine, the Company’s lead investigational therapy, to market. The ability to raise capital may be dependent upon market conditions that are outside the control of the Company. The ability of the Company to obtain approval from any regulatory agency for the sale of products to be developed on a commercial basis is uncertain. Ultimately, the Company must complete the development of its products, obtain the appropriate regulatory approvals and obtain sufficient revenues to support its cost structure. To finance the Company through marketing approval, the Company plans to raise additional capital in the form of corporate partnerships, and debt and/or equity financings. The Company believes that it will be able to obtain additional financing because it has done so consistently in the past and because Multikine showed great survival benefit in the Phase 3 study in one of the two treatment arms for advanced primary head and neck cancer. However, there can be no assurance that the Company will be successful in raising additional funds on a timely basis or that the funds will be available to the Company on acceptable terms or at all. If the Company does not raise the necessary amounts of money, it may have to curtail its operations until such time as it is able to raise the required funding. Due to the Company’s recurring losses from operations and future liquidity needs, there is substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.
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v3.24.2.u1
STOCKHOLDERS EQUITY
|
9 Months Ended |
Jun. 30, 2024 |
STOCKHOLDERS EQUITY |
|
STOCKHOLDERS' EQUITY |
C. STOCKHOLDERS’ EQUITY Proceeds from the Sale of Common Stock In February 2024, the Company sold 3,875,000 shares of common stock at a public offering price of $2.00 per share and received proceeds of approximately $7.0 million, net of issuance costs of approximately $0.7 million. In November 2023, the Company sold 2,490,000 shares of common stock at a public offering price of $2.00 per share and received proceeds of approximately $4.5 million, net of issuance costs of approximately $0.5 million. In April 2023, the Company sold 794,117 shares of common stock at a public offering price of $1.70 per share and received proceeds of approximately $1.4 million. The Company granted the underwriters a 30-day option to purchase up to 119,117 additional shares of common stock to cover over-allotments. The underwriter fully exercised this option in May 2023, resulting in additional proceeds to the Company of approximately $200,000. The Company incurred issuance costs of approximately $0.2 million related to this offering. Equity Compensation Underlying share information for equity compensation plans as of June 30, 2024 is as follows: Name of Plan | | Total Shares Reserved Under Plans | | Incentive Stock Option Plans | | | 138,400 | | Non-Qualified Stock Option Plans | | | 17,787,200 | | Stock Bonus Plans | | | 1,283,760 | | Stock Compensation Plans | | | 634,000 | | Incentive Stock Bonus Plan | | | 640,000 | |
Stock option activity: | | Nine months ended June 30, | | | | 2024 | | | 2023 | | Options granted | | | 1,967,500 | | | | 6,500 | | Options exercised | | | - | | | | - | | Options forfeited | | | 293,000 | | | | 179,832 | | Options expired | | | 27,075 | | | | 58,787 | |
| | Three Months Ended June 30, | | | | 2024 | | | 2023 | | Options granted | | | 1,964,500 | | | | 2,000 | | Options exercised | | | - | | | | - | | Options forfeited | | | 240,000 | | | | 57,500 | | Options expired | | | 40 | | | | 13,383 | |
On March 1, 2024, the Company accelerated the vesting of 234,332 stock options issued to directors to vest on April 19, 2024. The Company concluded that the change in vesting of the options should be treated as a modification in accordance with ASC 718. As such, the Company revalued the options as of March 1, 2024 (the modification date) and subtracted any compensation cost already recognized prior to the modification date. This resulted in remaining compensation cost of approximately $260,000 that was amortized on a straight-line basis over the remaining service period. The remaining compensation cost of approximately $101,000 as of March 31, 2024 was expensed during the three months ended June 30, 2024. Share-Based Compensation Expense: | | Nine months ended June 30, | | | | 2024 | | | 2023 | | Employees | | $ | 3,544,569 | | | $ | 4,976,338 | | Non-employees | | $ | 600,841 | | | $ | 473,723 | |
| | Three Months Ended June 30, | | | | 2024 | | | 2023 | | Employees | | $ | 728,120 | | | $ | 1,540,219 | | Non-employees | | $ | 230,678 | | | $ | 188,001 | |
Employee compensation expense includes the expense related to options and restricted stock that is expensed over the vesting periods. Non-employee expense includes the expense related to options and stock issued to consultants expensed over the period of the related service contracts. Warrants and Non-Employee Options The following chart represents the warrants and non-employee options outstanding at June 30, 2024: Warrant/ Options | | Issue Date | | Shares Issuable upon Exercise of Warrants/ Options | | | Exercise Price | | | Expiration Date | | Series N | | 8/18/2008 | | | 85,339 | | | $ | 3.00 | | | 8/18/2026 | | Series UU | | 6/11/2018 | | | 93,603 | | | $ | 2.80 | | | 6/30/2026 | | Series X | | 1/13/2016 | | | 120,000 | | | $ | 9.25 | | | 7/13/2026 | | Series Y | | 2/15/2016 | | | 26,000 | | | $ | 12.00 | | | 8/15/2026 | | Series MM | | 6/22/2017 | | | 333,432 | | | $ | 1.86 | | | 6/22/2026 | | Series NN | | 7/24/2017 | | | 200,087 | | | $ | 2.52 | | | 7/24/2026 | | Series RR | | 10/30/2017 | | | 234,009 | | | $ | 1.65 | | | 10/30/2026 | | Consultant Options | | 7/28/2017 – 9/2/2023 | | | 110,000 | | | | $1.39- $2.18 | | | 7/27/2027 - 9/1/2028 | |
1. Equity Warrants Changes in Equity Warrants No warrants recorded as equity were exercised during the nine months ended June 30, 2024. The following warrants recorded as equity were exercised during the nine months ended June 30, 2023. Warrants | | Warrants Exercised | | | Exercise Price | | | Proceeds | | Series RR | | | 17,752 | | | $ | 1.65 | | | $ | 29,291 | | Series SS | | | 200,000 | | | $ | 2.09 | | | | 418,000 | | | | | 217,752 | | | | | | | $ | 447,291 | |
No warrants recorded as equity expired during the nine and three months ended June 30,2024. On February 5, 2023, 600 Series TT warrants, with an exercise price of $2.24, expired. On May 4, 2024, the Company modified the terms of Series UU, X, Y, N, MM, NN and RR warrants by extending the expiration dates by twenty-four (24) months from their current expiration dates. The incremental cost of this extension was approximately $659,455, which was recorded as a deemed dividend in the financial statements for the nine and three months ended June 30, 2024. The Series N, X, MM, NN, RR and UU warrants are held by current Officers of the Company. On October 28, 2022, the expiration date of the Series RR warrants was extended two years from October 30, 2022 to October 30, 2024. The incremental cost of this extension was approximately $172,000, which was recorded as a deemed dividend. The Series RR warrants are held by current Officers of the Company. 2. Options and Shares Issued to Consultants During the nine months ended June 30, 2024 and 2023, the Company issued 321,761 and 115,321 shares, respectively, of restricted common stock to consultants for services. The weighted average grant date fair value of the shares issued to consultants was $1.84 and $2.45 during the nine months ended June 30, 2024 and 2023, respectively. During the three months ended June 30, 2024 and 2023, the Company issued 70,444 and 36,523 shares, respectively, of restricted common stock to consultants for services. The weighted average grant date fair value of the shares issued to consultants was $1.33 and $2.41 during the three months ended June 30, 2024 and 2023, respectively. No options were issued to a consultant during the nine months ended June 30, 2024. During the nine months ended June 30, 2023, 5,000 options with an exercise price of $11.61 issued to a consultant expired. During the nine months ended June 30, 2024 and 2023, the Company recorded total expense of approximately $601,000 and $474,000, respectively, relating to the share-based compensation under various consulting agreements. During the three months ended June 30, 2024 and 2023, the Company recorded total expense of approximately $231,000 and $188,000, respectively, relating to the share-based compensation under these consulting agreements. On June 30, 2024 and September 30, 2023, consulting fees of approximately $221,000 and $205,000, respectively, are included in current assets as prepaid expenses and will be amortized over the remaining service periods.
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v3.24.2.u1
RELATED PARTY TRANSACTIONS
|
9 Months Ended |
Jun. 30, 2024 |
RELATED PARTY TRANSACTIONS |
|
RELATED PARTY TRANSACTIONS |
D. RELATED PARTY TRANSACTIONS During the nine and three months ended June 30, 2024, certain officers and directors purchased 58,000 shares of restricted common stock at an aggregated fair market value of approximately $80,620. No restricted shares of the Company’s common stock were purchased by related parties during the nine and three months ended June 30, 2023. On May 4, 2024, the Company modified the terms of Series UU, X, Y, N, MM, NN and RR warrants by extending the expiration dates by twenty-four (24) months from their current expiration dates. The incremental cost of this extension was approximately $659,455, which was recorded as a deemed dividend in the financial statements for the three months ended June 30, 2024. The Series N, X, MM, NN, RR and UU warrants are held by Geert Kersten, Patricia Prichep (current Officers of the Company) and the de Clara Trust, of which the Company’s CEO, Geert Kersten, is a beneficiary. On October 28, 2022, the expiration date of the Series RR warrants was extended two years from October 30, 2022 to October 30, 2024 (Note C). The incremental cost of this extension was approximately $172,000, which was recorded as a deemed dividend.
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- DefinitionThe entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.
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v3.24.2.u1
COMMITMENTS AND CONTINGENCIES
|
9 Months Ended |
Jun. 30, 2024 |
COMMITMENTS AND CONTINGENCIES |
|
COMMITMENTS AND CONTINGENCIES |
E. COMMITMENTS AND CONTINGENCIES Clinical Research Agreement Under co-development and revenue sharing agreements with Ergomed, Ergomed agreed to contribute up to $12 million towards the Company’s Phase 3 Clinical Trial in the form of discounted clinical services in exchange for a single digit percentage of milestone and royalty payments, up to a specific maximum amount. The Company accounted for the co-development and revenue sharing agreements in accordance with ASC 808, Collaborative Arrangements. The Company determined the payments to Ergomed are within the scope of ASC 730, Research and Development. Therefore, the Company records the discount on the clinical services as a credit to research and development expense on its statements of operations. Since the inception of the agreement with Ergomed, the Company has incurred research and development expenses of approximately $35.8 million for Ergomed’s services. This amount is net of Ergomed’s discount of approximately $11.9 million. During the nine months ended June 30, 2024 and 2023, the Company recorded, net of Ergomed’s discount, approximately $0.1 million for each period as research and development expense related to Ergomed’s services. During the three months ended June 30, 2024 the Company did not record any research and development expense related to Egromed’s services and during three months ended June 30, 2023, the Company recorded, net of Ergomed’s discount, less than $0.1 million as research and development expense related to Ergomed’s services. Lease Agreements The Company leases a manufacturing facility near Baltimore, Maryland (the San Tomas lease). The building was remodeled in accordance with the Company’s specifications so that it can be used by the Company to manufacture Multikine for the Company’s Phase 3 clinical trial and sales of the drug if approved by any regulatory agency. The lease is for a term of twenty years and requires annual base rent to escalate each year at 3%. The Company is required to pay all real estate and personal property taxes, insurance premiums, maintenance expenses, repair costs and utilities. The lease allows the Company, at its election, to extend the lease for two ten-year periods or to purchase the building at the end of the 20-year lease, which expires in October 2028. The renewal options are not included in the calculation of the right of use asset and lease liability because exercise of those options is not reasonably certain. The San Tomas lease is classified as a finance lease on the Company’s balance sheet, as well as several other smaller finance leases for office equipment. The finance right of use assets are being depreciated using the straight-line method over the underlying lease terms. Total cash paid related to finance leases during the nine months ended June 30, 2024 and 2023 was approximately $2.0 and $1.9 million, respectively, of which approximately $0.7 and $0.8 million was for interest, respectively, in each nine-month period. As of June 30, 2024, the weighted average discount rate of the Company’s finance leases is 8.46% and the weighted average time to maturity is 4.34 years. On January 11, 2023, the Company was required to deposit approximately $2.3 million to its landlord, equivalent to one year’s rent, for falling below the stipulated cash threshold in accordance with the San Tomas lease. The amount will be included as an asset on the balance sheet until the Company meets the minimum cash balance required and the deposit is returned. Approximate future minimum lease payments under finance leases as of June 30, 2024 are as follows: Three months ending September 30, 2024 | | $ | 666,000 | | Year ending September 30, | | | | | 2025 | | | 2,747,000 | | 2026 | | | 2,838,000 | | 2027 | | | 2,929,000 | | 2028 | | | 3,021,000 | | 2029 | | | 255,000 | | Total future minimum lease obligation | | | 12,456,000 | | Less imputed interest on finance lease obligations | | | (2,029,000 | ) | Net present value of financing lease obligations | | | 10,427,000 | | Less net present value of financing lease obligations – current portion | | | (1,949,000 | ) | Net present value of financing lease obligations - non-current portion | | $ | 8,478,000 | |
The Company leases two facilities under operating leases. The lease for the Company’s office headquarters will expire on November 30, 2025. The lease for its research and development laboratory was renewed in September 2021 for an additional ten years and will expire on February 29, 2032. The renewal was considered a modification for accounting purposes and the right of use asset and liability were remeasured as of the date of the renewal. The operating leases include escalating rental payments. The Company is recognizing the related rent expense on a straight-line basis over the terms of the leases. The Company incurred lease expense for operating leases of approximately $0.3 million for both the nine months ended June 30, 2024 and 2023. Total cash paid related to operating leases during the nine months ended June 30, 2024 and 2023 was approximately $0.3 million for each period. The weighted average discount rate of the Company’s operating leases is 10.19% and the weighted average time to maturity is 7.16 years. As of June 30, 2024, approximate future minimum lease payments under operating leases are as follows: Three months ending September 30, 2024 | | $ | 90,000 | | Year ending September 30, | | | | | 2025 | | | 366,000 | | 2026 | | | 287,000 | | 2027 | | | 277,000 | | 2028 | | | 285,000 | | 2029 | | | 294,000 | | Thereafter | | | 746,000 | | Total future minimum lease obligation | | | 2,345,000 | | Less imputed interest on operating lease obligation | | | (640,000 | ) | Net present value of operating lease obligations | | | 1,705,000 | | Less net present value of operating lease obligations - current portion | | | (219,000 | ) | Net present value of operating lease obligations - non-current portion | | $ | 1,486,000 | |
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- DefinitionThe entire disclosure for commitments and contingencies.
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v3.24.2.u1
PATENTS
|
9 Months Ended |
Jun. 30, 2024 |
PATENTS |
|
PATENTS |
G. PATENTS During the nine and three months ended June 30, 2024 and 2023, there was no impairment of patent costs. The weighted average amortization period for patents is approximately 8 years. For the nine months ended June 30, 2024 and 2023, amortization of patent costs totaled approximately $25,000 and $29,000, respectively. For the three months ended June 30, 2024 and 2023, amortization of patent costs totaled approximately $7,000 and $9,000, respectively. The total estimated future amortization is as follows: Three months ending September 30, 2024 | | $ | 8,000 | | Year ending September 30, | | | | | 2025 | | | 29,000 | | 2026 | | | 25,000 | | 2027 | | | 22,000 | | 2028 | | | 19,000 | | 2029 | | | 16,000 | | Thereafter | | | 54,000 | | Total | | $ | 173,000 | |
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- DefinitionThe entire disclosure for all or part of the information related to intangible assets.
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v3.24.2.u1
LOSS PER COMMON SHARE
|
9 Months Ended |
Jun. 30, 2024 |
LOSS PER COMMON SHARE |
|
LOSS PER COMMON SHARE |
H. LOSS PER COMMON SHARE Basic loss per share is computed by dividing net loss available to common stockholders by the weighted average number of common shares outstanding during the period. The Company’s potentially dilutive shares, which include outstanding common stock options, common stock warrants and unvested restricted stock are not included in the computation of diluted net loss per share if their effect would be anti-dilutive. The following table provides a reconciliation of the numerators and denominators of the basic and diluted loss per-share computations: | | Nine Months Ended | | | Three Months Ended | | | | June 30, | | | June 30, | | Loss per share – basic and diluted | | 2024 | | | 2023 | | | 2024 | | | 2023 | | Net loss available to common – basic and diluted | | $ | (21,470,429 | ) | | $ | (24,735,151 | ) | | $ | (7,516,014 | ) | | $ | (8,367,281 | ) | Weighted average shares outstanding – basic and diluted | | | 51,479,454 | | | | 43,761,395 | | | | 53,994,384 | | | | 44,254,363 | | Basic and diluted loss per common share | | $ | (0.42 | ) | | $ | (0.57 | ) | | $ | (0.14 | ) | | $ | (0.19 | ) |
In accordance with the contingently issuable shares guidance of ASC 260, Earnings Per Share, the calculation of diluted net earnings (loss) per share excludes the following securities because their inclusion would have been anti-dilutive as of June 30 : | | 2024 | | | 2023 | | Options and Warrants | | | 17,497,453 | | | | 13,824,365 | | Unvested Restricted Stock | | | 147,250 | | | | 147,250 | | Total | | | 17,644,703 | | | | 13,971,615 | |
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v3.24.2.u1
SUBSEQUENT EVENTS
|
9 Months Ended |
Jun. 30, 2024 |
SUBSEQUENT EVENTS |
|
SUBSEQUENT EVENTS |
J. SUBSEQUENT EVENTS On July 11, 2024, Geert Kersten, the Company’s Chief Executive Officer and a director, loaned the Company $200,000. On July 18, 2024, Mr. Kersten loaned the Company an additional $250,000. These amounts were repaid on July 30, 2024. On July 29, 2024, the Company sold 3,715,000 shares of common stock at an offering price of $1.00 per share, and pre-funded warrants to purchase up to 7,130,000 shares of common stock, at an offering price of $0.99 per pre-funded warrant, for gross proceeds of approximately $10.8 million.
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- DefinitionThe entire disclosure for significant events or transactions that occurred after the balance sheet date through the date the financial statements were issued or the date the financial statements were available to be issued. Examples include: the sale of a capital stock issue, purchase of a business, settlement of litigation, catastrophic loss, significant foreign exchange rate changes, loans to insiders or affiliates, and transactions not in the ordinary course of business.
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v3.24.2.u1
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)
|
9 Months Ended |
Jun. 30, 2024 |
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies) |
|
Cash and Cash Equivalents |
Cash and Cash Equivalents – Cash and cash equivalents consist principally of unrestricted cash on deposit and short-term money market funds. The Company considers all highly liquid investments with a maturity when purchased of less than three months to be cash equivalents.
|
Property and Equipment |
Property and Equipment – Property and equipment is recorded at cost and depreciated using the straight-line method over estimated useful lives of five to seven years. Leasehold improvements are depreciated over the shorter of the estimated useful life of the asset or the term of the lease. Repairs and maintenance which do not extend the life of the asset are expensed when incurred. Property and equipment is reviewed on a quarterly basis to determine if any of the assets are impaired.
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Supplies used for R&amp;D and manufacturing |
Supplies used for R&D and manufacturing – Supplies are consumable items kept on hand to support the Company’s R&D and manufacturing operations. Supplies are recorded at cost and are charged to expense as they are used in operations.
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Patents |
Patents – Patent expenditures are capitalized and amortized using the straight-line method over the shorter of the expected useful life or the legal life of the patent (17 years). In the event changes in technology or other circumstances impair the value or life of the patent, appropriate adjustments to the asset value and period of amortization are made. An impairment loss is recognized when estimated future undiscounted cash flows expected to result from the use of the asset, and from its disposition, are less than the carrying value of the asset. The amount of the impairment loss would be the difference between the estimated fair value of the asset and its carrying value.
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Leases |
Leases – The Company accounts for contracts that convey the right to control the use of identified property, plant or equipment over a period of time in exchange for consideration as leases upon inception. The Company leases certain real estate, machinery, laboratory equipment and office equipment over varying periods. Many of these leases include an option to either renew or terminate the lease. For purposes of calculating lease liabilities, these options are included in the lease term when it is reasonably certain that the Company will exercise such options. The incremental borrowing rate utilized to calculate the lease liabilities is based on the information available at the commencement date, as most of the leases do not provide an implicit borrowing rate. Short-term leases, defined as leases with initial terms of 12 months or less, are not reflected on the balance sheet. Lease expense for such short-term leases is not material.
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Stock-Based Compensation |
Share-Based Compensation – Compensation cost for all share-based awards is measured at fair value as of the grant date in accordance with the provisions of ASC 718, Compensation – Stock Compensation (“ASC 718”). The fair value of stock options is calculated using the Black-Scholes option pricing model. The Black-Scholes model requires five input variables: the strike price of an option, the current stock price, the time to expiration, the risk-free rate, and the volatility. The share-based compensation cost is recognized using the straight-line method as expense over the requisite service or vesting period. The Company has Incentive Stock Option Plans, Non-Qualified Stock Option Plans, Stock Compensation Plans, Stock Bonus Plans and an Incentive Stock Bonus Plan. These Plans are collectively referred to as the “Plans”. All Plans have been approved by the Company’s stockholders. The Company’s stock options are not transferable, and the actual value of the stock options that an employee may realize, if any, will depend on the excess of the market price on the date of exercise over the exercise price. For options issued with service conditions only, the Company has based its assumption for stock price volatility on the variance of daily closing prices of the Company’s stock. The risk-free interest rate assumption is based on the U.S. Treasury rate at the date of grant with the term equal to the expected life of the option. Forfeitures are accounted for when they occur. The expected term of options represents the period that options granted are expected to be outstanding and has been determined based on an analysis of historical exercise behavior. If any of the assumptions used in the Black-Scholes model change significantly, share-based compensation expense for new awards may differ materially in the future from that recorded in the current period. Restricted stock granted under the Incentive Stock Bonus Plan and options granted under the Non-Qualified Stock Option Plans are subject to service, performance and market conditions and meet the classification of equity awards. These awards were measured at fair value on the grant dates using a Monte Carlo simulation for issuances where the attainment of performance criteria is uncertain. The total compensation cost will be expensed over the estimated requisite service period.
|
Research and Development Costs |
Research and Development Costs – Research and development costs are expensed as incurred. Management accrues Clinical Research Organization (“CRO”) expenses and clinical trial study expenses based on services performed and relies on the CROs to provide estimates of those costs applicable to the completion stage of a study. Estimated accrued CRO costs are subject to revisions as such studies progress to completion. The Company records revisions to estimated expense in the period in which the facts that give rise to the revision become known.
|
Net Loss Per Common Share |
Net Loss Per Common Share – The Company calculates net loss per common share in accordance with ASC 260, Earnings Per Share. Basic and diluted net loss per common share was determined by dividing net loss applicable to common shareholders by the weighted average number of common shares outstanding during the period. The Company’s potentially dilutive shares, which include outstanding common stock options, unvested restricted stock and common stock warrants, have not been included in the computation of diluted net loss per share for all periods as the result would be anti-dilutive.
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Income Taxes |
Income Taxes – The Company accounts for income taxes in accordance with the provisions of ASC 740, Income Taxes, on a tax jurisdiction basis. Deferred tax assets and liabilities are recognized for future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases and operating and tax loss carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. The Company records a valuation allowance to reduce the deferred tax assets to the amount that is more likely than not to be recognized. A full valuation allowance was recorded against the deferred tax assets as of June 30, 2024 and September 30, 2023.
|
Impairment of long-lived assets |
Impairment of long-lived assets – CEL-SCI’s fixed assets are made up of leasehold improvements, furniture, and equipment. ASC 360-10 requires that a long-lived asset group be reviewed for impairment only when events or changes in circumstances indicate that the carrying amount of the long-lived asset (group) might not be recoverable. CEL-SCI’s recurring losses are a triggering event that could indicate impairment of long-lived assets such as fixed assets. CEL-SCI reviews these assets to determine if events or changes in circumstances indicate the existence of impairment. If indicators of impairment exist, the Company tests for recoverability, then, if necessary, measures and records the impairment. The amount of the impairment loss would be the amount by which the carrying amount of the asset (group) exceeds its fair value.
|
Use of Estimates |
Use of Estimates – The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and the accompanying disclosures. These estimates are based on management’s best knowledge of current events and actions the Company may undertake in the future. Estimates are used in accounting for, among other items, inventory obsolescence, accruals, stock options, useful lives for depreciation and amortization of long-lived assets, right of use assets and lease liabilities, deferred tax assets and the related valuation allowance. Actual results could differ from estimates, although management does not generally believe such differences would materially affect the financial statements in any given year. Additionally, in calculating the right of use assets and lease liabilities, estimates and assumptions were used to determine the incremental borrowing rates and the expected lease terms. The Company considers the estimates used in valuing the stock options and the lease assets and liabilities to be significant.
|
Recently Adopted Accounting Standards |
In June 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update No. 2016-13, Financial Instruments – Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments (“ASU 2016-13”). ASU 2016-13 requires a financial asset (or a group of financial assets) measured at amortized cost basis to be presented at the net amount expected to be collected. The amendments in ASU 2016-13 replace the incurred loss impairment methodology in current U.S. GAAP with a methodology that reflects expected credit losses and requires consideration of a broader range of reasonable and supportable information. ASU 2016-13 was effective for SEC filers, excluding smaller reporting companies, for fiscal years beginning after December 15, 2019, including interim periods within those fiscal years. As a smaller reporting company, the Company was permitted to adopt the new standard for fiscal years beginning after December 15, 2022, including interim periods within those fiscal years. Effective October 1, 2023, the Company adopted ASU 2016-13 using a modified retrospective transition method. The adoption of ASU 2016-13 had no impact on the Company’s financial position, results of operations, or cash flows.
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New Accounting Pronouncements |
In November 2023, the FASB issued Accounting Standards Update No. 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures (“ASU 2023-07”), which expands disclosures about a public entity’s reportable segments and requires more enhanced information about a reportable segment’s expenses, interim segment profit or loss, and how a public entity’s chief operating decision maker uses reported segment profit or loss information in assessing segment performance and allocating resources. The update will be effective for annual periods beginning after December 15, 2023 and interim periods beginning after December 15, 2024. The Company is assessing the effect of this update on the condensed financial statement disclosures. In December 2023, the FASB issued Accounting Standards Update No. 2023-09, Improvements to Income Tax Disclosures, which require greater disaggregation of income tax disclosures related to the income tax rate reconciliation and income taxes paid. The update will be effective for annual periods beginning after December 15, 2024. The guidance should be applied on a prospective basis with the option to apply the standard retrospectively. Early adoption is permitted. The Company is currently evaluating the impact that this change will have on the Company's disclosures.
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v3.24.2.u1
COMMITMENTS AND CONTINGENCIES (Tables)
|
9 Months Ended |
Jun. 30, 2024 |
COMMITMENTS AND CONTINGENCIES |
|
Schedule of future minimum payments under finance leases |
Three months ending September 30, 2024 | | $ | 666,000 | | Year ending September 30, | | | | | 2025 | | | 2,747,000 | | 2026 | | | 2,838,000 | | 2027 | | | 2,929,000 | | 2028 | | | 3,021,000 | | 2029 | | | 255,000 | | Total future minimum lease obligation | | | 12,456,000 | | Less imputed interest on finance lease obligations | | | (2,029,000 | ) | Net present value of financing lease obligations | | | 10,427,000 | | Less net present value of financing lease obligations – current portion | | | (1,949,000 | ) | Net present value of financing lease obligations - non-current portion | | $ | 8,478,000 | |
|
Schedule of future minimum payments under operating leases |
Three months ending September 30, 2024 | | $ | 90,000 | | Year ending September 30, | | | | | 2025 | | | 366,000 | | 2026 | | | 287,000 | | 2027 | | | 277,000 | | 2028 | | | 285,000 | | 2029 | | | 294,000 | | Thereafter | | | 746,000 | | Total future minimum lease obligation | | | 2,345,000 | | Less imputed interest on operating lease obligation | | | (640,000 | ) | Net present value of operating lease obligations | | | 1,705,000 | | Less net present value of operating lease obligations - current portion | | | (219,000 | ) | Net present value of operating lease obligations - non-current portion | | $ | 1,486,000 | |
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v3.24.2.u1
STOCKHOLDERS EQUITY (Tables)
|
9 Months Ended |
Jun. 30, 2024 |
STOCKHOLDERS EQUITY |
|
Schedule of equity compensation plans |
Name of Plan | | Total Shares Reserved Under Plans | | Incentive Stock Option Plans | | | 138,400 | | Non-Qualified Stock Option Plans | | | 17,787,200 | | Stock Bonus Plans | | | 1,283,760 | | Stock Compensation Plans | | | 634,000 | | Incentive Stock Bonus Plan | | | 640,000 | |
|
Schedule of Stock option activity |
| | Nine months ended June 30, | | | | 2024 | | | 2023 | | Options granted | | | 1,967,500 | | | | 6,500 | | Options exercised | | | - | | | | - | | Options forfeited | | | 293,000 | | | | 179,832 | | Options expired | | | 27,075 | | | | 58,787 | |
| | Three Months Ended June 30, | | | | 2024 | | | 2023 | | Options granted | | | 1,964,500 | | | | 2,000 | | Options exercised | | | - | | | | - | | Options forfeited | | | 240,000 | | | | 57,500 | | Options expired | | | 40 | | | | 13,383 | |
|
Schedule of Stock-Based Compensation Expense |
| | Nine months ended June 30, | | | | 2024 | | | 2023 | | Employees | | $ | 3,544,569 | | | $ | 4,976,338 | | Non-employees | | $ | 600,841 | | | $ | 473,723 | |
| | Three Months Ended June 30, | | | | 2024 | | | 2023 | | Employees | | $ | 728,120 | | | $ | 1,540,219 | | Non-employees | | $ | 230,678 | | | $ | 188,001 | |
|
Schedule of warrants and non-employee options outstanding |
Warrant/ Options | | Issue Date | | Shares Issuable upon Exercise of Warrants/ Options | | | Exercise Price | | | Expiration Date | | Series N | | 8/18/2008 | | | 85,339 | | | $ | 3.00 | | | 8/18/2026 | | Series UU | | 6/11/2018 | | | 93,603 | | | $ | 2.80 | | | 6/30/2026 | | Series X | | 1/13/2016 | | | 120,000 | | | $ | 9.25 | | | 7/13/2026 | | Series Y | | 2/15/2016 | | | 26,000 | | | $ | 12.00 | | | 8/15/2026 | | Series MM | | 6/22/2017 | | | 333,432 | | | $ | 1.86 | | | 6/22/2026 | | Series NN | | 7/24/2017 | | | 200,087 | | | $ | 2.52 | | | 7/24/2026 | | Series RR | | 10/30/2017 | | | 234,009 | | | $ | 1.65 | | | 10/30/2026 | | Consultant Options | | 7/28/2017 – 9/2/2023 | | | 110,000 | | | | $1.39- $2.18 | | | 7/27/2027 - 9/1/2028 | |
|
Schedule of derivative liabilities |
Warrants | | Warrants Exercised | | | Exercise Price | | | Proceeds | | Series RR | | | 17,752 | | | $ | 1.65 | | | $ | 29,291 | | Series SS | | | 200,000 | | | $ | 2.09 | | | | 418,000 | | | | | 217,752 | | | | | | | $ | 447,291 | |
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v3.24.2.u1
PATENTS (Tables)
|
9 Months Ended |
Jun. 30, 2024 |
PATENTS |
|
Schedule of total estimated future amortization |
Three months ending September 30, 2024 | | $ | 8,000 | | Year ending September 30, | | | | | 2025 | | | 29,000 | | 2026 | | | 25,000 | | 2027 | | | 22,000 | | 2028 | | | 19,000 | | 2029 | | | 16,000 | | Thereafter | | | 54,000 | | Total | | $ | 173,000 | |
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v3.24.2.u1
LOSS PER COMMON SHARE (Tables)
|
9 Months Ended |
Jun. 30, 2024 |
LOSS PER COMMON SHARE |
|
Schedule of reconciliation of the numerators and denominators of the basic and diluted per-share computations |
| | Nine Months Ended | | | Three Months Ended | | | | June 30, | | | June 30, | | Loss per share – basic and diluted | | 2024 | | | 2023 | | | 2024 | | | 2023 | | Net loss available to common – basic and diluted | | $ | (21,470,429 | ) | | $ | (24,735,151 | ) | | $ | (7,516,014 | ) | | $ | (8,367,281 | ) | Weighted average shares outstanding – basic and diluted | | | 51,479,454 | | | | 43,761,395 | | | | 53,994,384 | | | | 44,254,363 | | Basic and diluted loss per common share | | $ | (0.42 | ) | | $ | (0.57 | ) | | $ | (0.14 | ) | | $ | (0.19 | ) |
|
Schedule of anti-dilutive securities |
| | 2024 | | | 2023 | | Options and Warrants | | | 17,497,453 | | | | 13,824,365 | | Unvested Restricted Stock | | | 147,250 | | | | 147,250 | | Total | | | 17,644,703 | | | | 13,971,615 | |
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v3.24.2.u1
STOCKHOLDERS EQUITY (Details 1) - shares
|
3 Months Ended |
9 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
STOCKHOLDERS EQUITY |
|
|
|
|
Options Granted |
1,964,500
|
2,000
|
1,967,500
|
6,500
|
Options Forfeited |
240,000
|
57,500
|
293,000
|
179,832
|
Option Exercised |
0
|
0
|
0
|
0
|
Options Expired |
40
|
13,383,000
|
27,075
|
58,787
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v3.24.2.u1
STOCKHOLDERS EQUITY (Details 2) - USD ($)
|
3 Months Ended |
9 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Employees |
|
|
|
|
Stock Based Compensation Expense |
$ 728,120
|
$ 1,540,219
|
$ 3,544,569
|
$ 4,976,338
|
Non-employees |
|
|
|
|
Stock Based Compensation Expense |
$ 230,678
|
$ 188,001
|
$ 600,841
|
$ 473,723
|
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v3.24.2.u1
STOCKHOLDERS EQUITY (Details Narrative) - USD ($)
|
1 Months Ended |
3 Months Ended |
9 Months Ended |
|
Feb. 29, 2024 |
Nov. 30, 2023 |
May 31, 2023 |
Oct. 28, 2022 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Sep. 30, 2023 |
Common stock shares issued |
3,875,000
|
2,490,000
|
|
|
54,257,884
|
|
54,257,884
|
|
47,422,304
|
Public offering price |
$ 2
|
$ 2.00
|
|
|
|
|
|
|
|
Proceeds from issuance of common stock |
$ 7,000,000
|
$ 4,500,000
|
|
|
|
|
$ 12,730,000
|
$ 1,552,497
|
|
Amortization cost |
|
|
|
|
$ 101,000
|
|
260,000
|
|
|
Net of issuance costs |
$ 700,000
|
$ 500,000
|
|
|
|
|
|
|
|
Stock options |
|
|
|
|
|
|
$ 234,332
|
|
|
Consulting Agreements [Member] |
|
|
|
|
|
|
|
|
|
Weighted average grant date fair value |
|
|
|
|
|
|
$ 1.84
|
$ 2.45
|
|
Options issued |
|
|
|
|
|
|
|
5,000
|
|
Consulting fees inclued prepaid expenses |
|
|
|
|
221,000
|
|
$ 221,000
|
|
$ 205,000
|
Total expense |
|
|
|
|
$ 231,000
|
$ 188,000
|
$ 601,000
|
$ 474,000
|
|
Consulting Agreements Other [Member] |
|
|
|
|
|
|
|
|
|
Weighted average grant date fair value |
|
|
|
|
|
|
$ 11.61
|
|
|
Restricted Stock [Member] | Consultants [Member] |
|
|
|
|
|
|
|
|
|
Weighted average grant date fair value |
|
|
|
|
$ 1.33
|
$ 2.41
|
$ 2.24
|
|
|
Common stock issued for service, shares |
|
|
|
|
70,444
|
36,523
|
321,761
|
115,321
|
|
Common Stock sale [Member] |
|
|
|
|
|
|
|
|
|
Public offering price |
|
|
|
|
$ 1.70
|
|
$ 1.70
|
|
|
Proceeds from issuance of common stock |
|
|
$ 200,000
|
|
|
|
$ 1,400,000
|
|
|
Issuance cost of common stock |
|
|
|
|
|
|
$ 200,000
|
|
|
Sale of common stock at a public offering price |
|
|
|
|
|
|
794,117
|
|
|
Additional purchase of common stock |
|
|
|
|
|
|
119,117
|
|
|
Series RR [Member] |
|
|
|
|
|
|
|
|
|
Incremental cost |
|
|
|
$ 172,000
|
|
|
$ 659,455
|
|
|
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v3.24.2.u1
RELATED PARTY TRANSACTIONS (Details Narrative ) - Officer And Director [Member] - USD ($)
|
|
1 Months Ended |
3 Months Ended |
9 Months Ended |
May 04, 2024 |
Oct. 28, 2023 |
Jun. 30, 2024 |
Jun. 30, 2024 |
Incremental cost |
$ 659,455
|
$ 172,000
|
|
|
Purchase of newly issued shares by insiders |
|
|
58,000
|
58,000
|
Purchase of restricted common stock fair value |
|
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$ 80,620
|
$ 80,620
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v3.24.2.u1
COMMITMENTS AND CONTINGENCIES (Details)
|
Jun. 30, 2024
USD ($)
|
COMMITMENTS AND CONTINGENCIES |
|
Three months ending September 30, 2024 |
$ 666,000
|
2025 |
2,747,000
|
2026 |
2,838,000
|
2027 |
2,929,000
|
2028 |
3,021,000
|
2029 |
255,000
|
Total future minimum lease obligation |
12,456,000
|
Less imputed interest on finance lease obligations |
(2,029,000)
|
Net present value of financing lease obligations |
10,427,000
|
Less net present value of financing lease obligations - current portion |
(1,949,000)
|
Net present value of financing lease obligations - non-current portion |
$ 8,478,000
|
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v3.24.2.u1
COMMITMENTS AND CONTINGENCIES (Details 1)
|
Jun. 30, 2024
USD ($)
|
COMMITMENTS AND CONTINGENCIES |
|
Three months ending September 30, 2024 |
$ 90,000
|
2025 |
366,000
|
2026 |
287,000
|
2027 |
277,000
|
2028 |
285,000
|
2029 |
294,000
|
Thereafter |
746,000
|
Total Future Minimum Lease Obligation |
2,345,000
|
Less Imputed Interest On Operating Lease Obligation |
(640,000)
|
Net Present Value Of Operating Lease Obligation |
1,705,000
|
Net present value of lease finance lease obligations - current portion |
(219,000)
|
Net present value of lease finance lease obligations - non-current portion |
$ 1,486,000
|
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v3.24.2.u1
COMMITMENTS AND CONTINGENCIES (Details Narrative) - USD ($)
|
|
3 Months Ended |
9 Months Ended |
|
Jan. 11, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Dec. 31, 2023 |
Interest amount |
|
|
|
$ 700,000
|
$ 800,000
|
|
Lease expense for operating leases |
|
|
|
300,000.0
|
300,000
|
|
Total cash payment for oprating lease |
|
|
|
$ 300,000
|
300,000.0
|
|
Annual increase to interest payments |
|
8.46%
|
|
8.46%
|
|
3.00%
|
Weighted average time of maturity of operating leases |
|
4 years 4 months 2 days
|
|
7 years 1 month 28 days
|
|
|
Research and development expenses |
|
$ 35,800,000
|
|
|
|
|
Weighted average discount rate operating lease |
|
10.19%
|
|
10.19%
|
|
|
Lease Agreements [Member] |
|
|
|
|
|
|
Total cash payment for oprating lease |
|
|
|
$ 2,000,000
|
1,900,000
|
|
Landlord [Member] |
|
|
|
|
|
|
Financing arrangement deposit base rent amount |
$ 2,300,000
|
|
|
|
|
|
Ergomed [Member] |
|
|
|
|
|
|
Net Of Discount |
|
|
|
11,900,000
|
|
|
Research and development expenses |
|
|
$ 100,000
|
100,000
|
$ 100,000.0
|
|
Clinical service trial |
|
|
|
$ 12,000,000
|
|
|
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PATENTS (Details)
|
Jun. 30, 2024
USD ($)
|
PATENTS |
|
Three months ending September 30, 2024 |
$ 8,000
|
2025 |
29,000
|
2026 |
25,000
|
2027 |
22,000
|
2028 |
19,000
|
2029 |
16,000
|
Thereafter |
54,000
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Total |
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LOSS PER COMMON SHARE (Details) - USD ($)
|
3 Months Ended |
9 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
LOSS PER COMMON SHARE |
|
|
|
|
Net loss available to common shareholders - basic and diluted |
$ (7,516,014)
|
$ (8,367,281)
|
$ (21,470,429)
|
$ (24,735,151)
|
Loss per share- basic and diluted |
|
|
|
|
Weighted average shares outstanding - basic and diluted |
53,994,384
|
44,254,363
|
51,479,454
|
43,761,395
|
Basic and diluted loss per common share |
$ (0.14)
|
$ (0.19)
|
$ (0.42)
|
$ (0.57)
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LOSS PER COMMON SHARE (Details 1) - shares
|
9 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Antidilutive Securities |
17,644,703
|
13,971,615
|
Options and Warrants |
|
|
Antidilutive Securities |
17,497,453
|
13,824,365
|
Unvested Restricted Stock [Member] |
|
|
Antidilutive Securities |
147,250
|
147,250
|
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v3.24.2.u1
SUBSEQUENT EVENTS (Details Narrative) - USD ($)
|
1 Months Ended |
3 Months Ended |
|
Jul. 29, 2024 |
Jul. 18, 2024 |
Mar. 31, 2024 |
Dec. 31, 2023 |
Jun. 30, 2023 |
Jul. 11, 2024 |
Proceeds from newly issued shares |
|
|
$ 7,750,000
|
$ 4,980,000
|
$ 1,552,497
|
|
Subsequent Event [Member] |
|
|
|
|
|
|
Public offering price |
$ 1.00
|
|
|
|
|
|
Pre funded warrants offering price |
$ 0.99
|
|
|
|
|
|
Sale of common stock at a public offering price |
3,715,000
|
|
|
|
|
|
Proceeds from newly issued shares |
$ 10,800,000
|
|
|
|
|
|
Pre-funded warrants to purchase common stock |
7,130,000
|
|
|
|
|
|
Subsequent Event [Member] | Mr. Kersten [Member] |
|
|
|
|
|
|
Additional loan amount |
|
$ 250,000
|
|
|
|
|
Subsequent Event [Member] | Chief Executive Officer [Member] |
|
|
|
|
|
|
Amount of loan |
|
|
|
|
|
$ 200,000
|
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