Filed
Pursuant to Rule 433
Issuer
Free Writing Prospectus dated March 4, 2010
Relating
to Prospectus dated January 5, 2010
and
Prospectus Supplement dated March 5, 2010
Registration
Statement No. 333-163987
INTERLEUKIN
GENETICS, INC.
FREE
WRITING PROSPECTUS
The
following article was published by The Wall Street Journal on March 4,
2010. Interleukin Genetics, Inc. (“Interleukin” or, the “Company”)
did not prepare or review this article in advance of its publication. The
publisher of this article is not affiliated with the Company, and the Company
made no payment and gave no consideration to the publisher in consideration for
the publication of the article. This article is being filed because of the
timing of its appearance and because it contains a statement attributed to
Kenneth S. Kornman, the President and Chief Scientific Officer of
Interleukin. The Company does not endorse any other statement
expressed in the article.
Certain
statements contained in the article are “forward-looking” statements.
Because such statements include risks and uncertainties, actual results may
differ materially from those expressed or implied by such forward-looking
statements. Factors that could cause actual results to differ materially
from those expressed or implied by such forward-looking statements include those
risks and uncertainties described in the Company’s annual report on Form
10-K for the year ended December 31, 2008, quarterly reports on Form 10-Q and
other filings with the Securities and Exchange Commission (SEC). The Company
disclaims any obligation or intention to update these forward-looking
statements.
The
issuer has filed a registration statement (including a prospectus and prospectus
supplement) with the SEC for the offering to which this communication relates.
Before you invest, you should read the prospectus and accompanying prospectus
supplement in that registration statement and other documents the issuer has
filed with the SEC for more complete information about the issuer and this
offering. You may obtain these documents for free by visiting EDGAR on the SEC
Web site at
www.sec.gov
. Alternatively,
the issuer will arrange to send you a copy of these documents if you request
them by calling toll free at 866-990-4363.
* * *
Genes
Point to Best Diets
Study
Shows Some Women Benefit From Low-Fat Plan, Others From Low-Carb
By Ron
Winslow
SAN
FRANCISCO - In the long-running debate over diets - low-fat or low-carb -
Stanford University researchers reported Wednesday that a genetic test can help
people choose which one works best for them.
In a
study involving 133 overweight women, those with a genetic predisposition to
benefit from a low-carbohydrate diet lost 2½ times as much weight as those on
the same diet without the predisposition. Similarly, women with a
genetic makeup that favored a low-fat diet lost substantially more weight than
women who curbed fat calories without low-fat genes. The women were
followed for a year.
“Knowing
your genotype for low-carb or low-fat diets could help you increase your
weight-loss success,” said Christopher Gardner, an associate professor of
medicine at Stanford and a co-author of the study.
Data from
a separate study indicate that 45% of white women have a low-carb geno-type
while 39% are predisposed to a low-fat diet, suggesting the test has the
potential to yield a useful result for much of the population. The test is based
on variations in three genes known to regulate how the body metabolizes fat and
carbohydrates.
The
findings need confirmation in a larger study, and additional research is also
necessary to determine how it applies to men and different racial
groups.
The
results help explain a common phenomenon in the weight-loss wars: why two people
decide to lose weight and go on the same diet and exercise plan, only to have
one succeed while the other is frustrated.
The
results suggest even strict adherence to a diet won’t matter if people’s diets
are out of synch with their genetics, he added.
The test
was developed by Interleukin Genetics Inc., a Waltham, Mass., developer of
genetic tests that sponsored the study. The test uses a cheek swab to
obtain cells for DNA analysis, and is on the market for $149.
In the
past decade, about a dozen studies pitting low-fat vs. low-carb diets have been
published in major medical journals. For the most part, no winner has
emerged, and none of the diets resulted, on average, in weight loss exceeding 10
pounds in a year. Experts began to believe the type of diet didn’t
matter.
“This
makes the whole topic relevant again,” Dr. Gardner said.
Researchers
said that determining a person’s genetic predisposition could become a new tool
in the battle against overweight and obesity.
“This is
one step forward to realizing personalized nutrition for weight loss,” said
Mindy Dopler Nelson, a researcher at Stanford and lead author of the
report. The researchers said they didn’t have any financial interest
in the Interleukin Genetics test.
“To match
individuals with a diet type will help us to better target interventions and
help them be successful,” added Sachiko St. Jeor, a professor in the division of
endocrinology, nutrition and metabolism at University of Nevada School of
Medicine, Reno. Dr. St. Jeor wasn't involved with the study.
The
study, presented at the American Heart Association’s annual epidemiology and
prevention conference, has just been submitted to a medical journal and thus
hasn't yet cleared rigorous peer review that precedes publication. But it was
reviewed by a committee that, approves papers for presentation at the
meeting.
Despite
the relatively small number of participants, the findings achieved strong
statistical significance, researchers said, meaning it isn't likely they were
the result of chance. The findings are also based in part on an earlier paper,
called the A to Z weight-loss study published in the Journal of the American
Medical Association in 2007.
Just
matching the right diet with your genes doesn't guarantee significant weight
loss for everyone, Dr. Gardner cautioned. If low-carb people make a diet out of
low-carb cupcakes, he said, they're unlikely to see the results they want on a
scale.
The 133
women were among 301 participants in the A to Z study, which compared the
effects of four popular weight-loss diets: the Atkins and Zone diets, which are
low-carb, and the Learn and Ornish diets, which call for curbing fat
calories.
In that
study, the Atkins diet was slightly more effective. than the other three, but on
average, the total weight loss after one year was only about 10
pounds.
Yet, Dr,
Nelson pointed out, within each diet group, a handful of women lost more than 30
pounds, while some others gained about 10 pounds. The new study examined whether
genetics could explain part of the more than 40-pound swing.
Kenneth
S. Kornman, president and chief scientific officer at Interleukin, said the
company asked if the Stanford team could use its genetic test on the A to Z
participants to see if their genetic makeup predicted their weight-loss
experience.
Since
Stanford researchers hadn't obtained DNA samples, Dr. Nelson led an effort to
track down the original participants. She said over 130 agreed to submit cheek
swab samples to determine genetic predisposition.
The
article is accompanied by a graphic entitled “Dietary DNA - How a genetic
variation affected weight loss in a study of four popular diets.”
The
graphic provides a brief description of the following four diets:
|
·
|
Ornish
diet:
Concentrates on removing fats and cholesterol,
promotes consuming mostly whole grains, legumes, fruits and
vegetables.
|
|
·
|
Learn
diet:
Stands for Lifestyle, Exercise, Attitudes,
Relationships, and Nutrition. Recommends 55% - 60% from carbs
and less than 10% from saturated
fat.
|
|
·
|
Zone diet:
Advocates
balance. Diet centers on a ’40:30:30’ ratio of calories
obtained from carbohydrates, proteins and fats,
respectively.
|
|
·
|
Atkins diet:
Promotes
low-carbohydrate, high-protein meals. Recommends no more than
20% of calories from saturated fat.
|
The
following data is also depicted in graphic form:
|
·
|
Ornish
diet:
Study participants following this lowest fat diet
who had the low-fat gene lost an average of 14.1 pounds as compared to
study participants following this diet who had the low-carb gene who lost
an average of 3.1 pounds.
|
|
·
|
Learn
diet:
Study participants following this diet who had the
low-fat gene lost an average of 10.1 pounds as compared to study
participants following this diet who had the low-carb gene who lost an
average of 6.8 pounds.
|
|
·
|
Zone diet:
Study
participants following this diet who had the low-fat gene lost an average
of 5.3 pounds as compared to study participants following this diet who
had the low-carb gene who lost an average of 5.3
pounds.
|
|
·
|
Atkins diet:
Study
participants following this lowest carb diet who had the low-carb gene
lost an average of 12.3 pounds as compared to study participants following
this diet who had the low-fat gene who lost an average of 2.2
pounds.
|
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