RNS Number:3993R
Skyepharma PLC
28 October 2003


For Immediate Release                                            28 October 2003



                         SkyePharma PLC ("the Company")

                    Notification of Major Interest in Shares


In accordance with Part VI of the Companies Act 1985 (as amended) the Company
was informed on 28 October 2003 that on 27 October 2003 Standard Life
Investments, on behalf of the Standard Life Group, purchased 250,000 SkyePharma
plc Ordinary Shares, thus increasing their holding to 18,753,893 Ordinary
Shares, representing 3.035% of the issued share capital of the Company. These
Ordinary Shares are registered in the name of Stanlife Nominees Limited.


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