The world's biggest miners are hemorrhaging jobs as the price for almost everything they dig up—from gold to aluminum to copper—slides relentlessly downward.

Anglo American PLC, the U.K. mining titan, on Friday announced the most dramatic job-reduction figure yet in the ailing industry, saying it would slash 53,000 jobs over the next several years— including 6,000 in the corporate offices amounting to $500 million in savings. That would amount to a reduction of 35% of its current workforce of 151,000.

"We're looking at every dollar and pulling everything back," Anglo-American Chief Executive Mark Cutifani said in a presentation of the miner's first-half earnings results to investors Friday. "It's a constant process driving out costs."

Also on Friday, South Africa's Lonmin PLC said it would cut 6,000 workers over the next two years. BHP Billiton has recently cut hundreds of jobs linked to its giant copper, gold and uranium mine, Olympic Dam, in South Australia so far this year. Fortescue Metals Group Ltd., the world's fourth largest iron-ore exporter, on Thursday didn't rule out further job cuts as it said it intends to cut costs in the year ahead by nearly the same amount it slashed in the two past fiscal years combined.

Tens of thousands of jobs are estimated to be have been cut across Australia, from the coal fields of Queensland state to the goldfields of the country's west, over the past couple of years.

Staff cuts are among the measures miners are taking to lower their costs amid a historic downturn in commodity prices driven by China's abrupt economic slowdown. Anglo and other big miners such as Rio Tinto PLC have also moved to restructure organizations that had grown quickly when China was gobbling up commodities. Anglo is trying to sell more than a quarter of its assets, while BHP recently spun off more than a dozen mines into a separate, public company called South32.

The moves come as oil companies and their service contractors— roiled by a similar price collapse in the crude market—shed tens of thousands of jobs and are moving to reshape their operations for what could be a long period of lowered commodity prices.

The market for what the big miners sell continued to fall on Friday. Three-month copper futures fell to $5,202.50, their lowest level in six years, as a preliminary gauge China's manufacturing activity dropped to a 15-month low in July. Prices of three-month aluminum, another heavily-traded base metal, also dropped to a six-year low at $1,634 per ton.

Anglo's financial results were hit across all of the commodities it sells, but particularly in iron ore. The price for that key ingredient in steelmaking fell below $50 a ton this year, down from highs of $190 a ton in 2011.

Overall, the company reported a $3 billion loss for the first half, including a one-time $2.9 billion from a write-down in the value of Anglo American's huge Minas-Rio iron-ore project in Brazil.

Experts, including Glencore PLC Chief Executive Ivan Glasenberg, have argued that much of the decline in commodity prices has been driven by overproduction as mining operations launched several years ago during the so-called "supercycle," driven by Chinese demand, come into production.

Jefferies analyst Christopher LaFemina said in a note this week that the "second meltdown phase" for miners, driven by ever-worsening demand, has recently begun.

"Prices for industrial commodities are unlikely to recover until demand improves," he wrote.

None of the big diversified miners has suffered as much as Anglo, which Mr. Cutifani took over in 2013 with high hopes of turning it around. Instead, the company's profits have fallen further. Its share price has hovered at or near 13-year lows in recent weeks.

The job cuts are among the most drastic measures he has announced, as he looks to make the world's fifth-largest miner by market valuation more efficient. They will bring the miners' total workforce down to about 98,000 people, though some of that is dependent on Mr. Cutifani's ability to sell some mines—something he has had trouble doing.

Write to Scott Patterson at scott.patterson@wsj.com

Rhiannon Hoyle in Sydney contributed to this article.

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