By Sabela Ojea

International stocks trading in New York closed mostly lower on Wednesday.

The S&P/BNY Mellon index of American depositary receipts fell 0.08% to 150.05. The European index declined 0.3% to 150.68, the Asian index rose 0.5% to 163.83, the Latin American index dropped 0.4% to 182.77 and the emerging markets index increased 0.06% to 270.86.

ADRs of Dassault Systemes SE dropped 5.8% to $38.32 after the French software company reported lower first-quarter adjusted operating margin, and said it targets a lower adjusted margin for the current quarter.

ADRs of LianBio closed up 2.1% to $1.97 after the Shanghai and Princeton, N.J.-based biotechnology company said it saw positive topline results from a Phase 3 investigating mavacamten for the treatment of Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy.

Write to Sabela Ojea at sabela.ojea@wsj.com; @sabelaojeaguix

(END) Dow Jones Newswires

April 26, 2023 18:36 ET (22:36 GMT)

Copyright (c) 2023 Dow Jones & Company, Inc.
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