RNS Number:8869W Pharmagene PLC 8 January 2001 DEALINGS BY SUBSTANTIAL SHAREHOLDERS 1) NAME OF COMPANY PHARMAGENE PLC 2) NAME OF SHAREHOLDER HAVING A MAJOR INTEREST DR NOWELL STEBBING AND ABACUS NOMINEES LIMITED V0326 (CONNECTED PERSON) 3) Please state whether notification indicates that it is in respect of holding of the Shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 HOLDING OF DR NOWELL STEBBING AND ABACUS NOMINEES LIMITED V0326 4) Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them. DR NOWELL STEBBING - 1,163,064 SHARES ABACUS NOMINEES LIMITED V0326 - 826,165 SHARES 5) Number of shares/amount of stock acquired. 172,000 6) ( 0.33% ) of issued Class 7) Number of shares/amount of stock disposed 8) ( N/A %) of issued Class 9) Class of security ORDINARY SHARES 10) Date of transaction 27/12/00 11) Date company informed 5/1/01 12) Total holding following this notification 1,991,229 13) Total percentage holding of issued class following this notification 3.92% 14) Any additional information ABACUS NOMINEES LIMITED V0326 IS A CONNECTED PERSON 15) Name of contact and telephone number for queries MR J W BUCKIE 01763 211600 16) Name and signature of authorised company official responsible for making this notification Date of Notification 8/1/2001 DEALINGS BY DIRECTORS 1) NAME OF COMPANY PHARMAGENE PLC 2) NAME OF DIRECTOR DR NOWELL STEBBING 3) Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 or in respect of an non-beneficial interest HOLDING OF ABACUS NOMINEES LIMITED - CONNECTED PERSON 4) Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them. (If notified) ABACUS NOMINEES LIMITED V0326 828,165 ORDINARY SHARES 5) Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s) ABACUS NOMINEES LIMITED V0326 - CONNECTED PERSON 6) Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary ACQUISITION OF SHARES 7) Number of shares/amount of stock acquired 172,000 8) ( 0.33% ) of issued Class 9) Number of shares/amount of stock disposed 10) ( N/A %) of issued Class 11) Class of security ORDINARY SHARES 12) Price per share #1.15 13) Date of transaction 27/12/00 14) Date company informed 5/1/01 15) Total holding following this notification 828,165 16) Total percentage holding of issued class following this notification 1.63% IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE COMPLETE THE FOLLOWING BOXES 17) Date of grant 18) Period during which or date on which exercisable 19) Total amount paid (if any) for grant of the option 20) Description of shares or debentures involved: class, number. 21) Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise 22) Total number of shares or debentures over which options held following this notification 23) Any additional information 24) Name of contact and telephone number for queries MR J W BUCKIE - 01763 211600 25) Name and signature of authorised company official responsible for making this notification Date of Notification 8/1/2001 10