HUGO Pacific Pan-Asian SNP Initiative to Explore Genetic Diversity for Nearly Half the World's Population Study Expects to Provide a Detailed and Comprehensive Genetic Picture of Asian Populations BIOPOLIS, Singapore, Nov. 18 /PRNewswire-FirstCall/ -- A coalition of scientists from Asian countries announced today that they are organizing a study of genetic diversity in Asian populations, the HUGO Pacific Pan-Asian SNP Initiative, which will provide a detailed and comprehensive genetic picture of nearly half the world's population. The results from the study will be placed in a public database to help researchers better understand the scope of genetic differences between Asian populations. International collaboration The Pan-Asian SNP Initiative was established by scientists from China, India, Indonesia, Japan, Korea, Malaysia, Nepal, Philippines, Singapore, Thailand and Taiwan. Affymetrix, Inc. (NASDAQ:AFFX) is a co-sponsor of the study and is providing a new microarray technology that will enable the researchers to look at 50,000 genetic differences, or single nucleotide polymorphisms (SNPs) in each study participant. The goal of this initiative is to uncover the breadth of genetic diversity and the extent of genetic similarity in Asia. This information will form the basis for future studies in genomic medicine focused on Asian populations. First detailed look at Asian "genetic history" The study is a natural next step from the Human Genome Project, which showed how similar humans are -- everyone's DNA is 99.9 percent identical -- but revealed little about the genetic factors that make us different. "Just as families share certain genetic characteristics, like eye colour or curly hair, Pan-Asian scientists believe that regional Asian populations share unique genetic variations that go back thousands of years," said Professor Edison Liu, Executive Director, Genome Institute of Singapore. "The study will give scientists a 'genetic map' of human history in Asia, showing how nearly half of the world's population migrated throughout the region and settled to form the distinct cultures that we know today." A picture of a population's genetic profile The Pan-Asian study will also help scientists understand the most important genetic differences between Asian populations, including those that can affect health. "Data from the Pan-Asian study will provide a platform for researchers in this region to study why some populations seem predisposed to certain diseases, or don't respond to certain drugs," said Dr. Yoshi Sakaki, Director, RIKEN Genomics Center in Yokohama, Japan and President of HUGO Pacific. "The initiative will also provide training in population genetics for young researchers in this region and foster additional health studies." New technology enables new science The study will include as many as several hundred people from each of the Asian countries mentioned above, sampling about 2,600 participants in the first phase. Up to now, a study like the Pan-Asian SNP Initiative would have been difficult because the technology needed to look at the genome at this level of detail was not readily accessible. This new SNP microarray technology makes it possible by combining semi-conductor manufacturing technology with chemistry to put millions of different strands of DNA on a single glass chip the size of a thumbnail. "Just a couple of years ago, an experiment like this would have required hundreds of scientists and taken years to complete at costs that would have been prohibitive," said Professor Liu. "This technology is enabling us to do new science; it's opening up the study to all researchers including those with less developed research infrastructures." The study is expected to begin in the middle of 2005. About HUGO Pacific: The Human Genome Organization (HUGO) is an international organization based in the UK and established in 1989 by a group of scientists originally involved in the Human Genome Project (HGP). The HUGO Pacific, which is sponsoring the Pan-Asian SNP Initiative, is a chapter of the main HUGO. Its office is based at the University of Tokyo, Japan. HUGO Pacific has held four conferences in the Asia-Pacific region together with the Asia-Pacific Conference on Human Genetics. Singapore is a founding member of the HUGO Pacific together with Japan, China, Korea, Indonesia, Thailand and Malaysia. DATASOURCE: Affymetrix, Inc. CONTACT: William Chia, +65 6424 6387, or mobile, +65 9684 3800, or , or Gail McIsaac, +65 6424 6370, or mobile, +65 9824 1475, or , both of Fleishman-Hillard Pte Ltd, for Affymetrix, Inc.; or Daniel Lum, Secretariat of Pan-Asian SNP Initiative 2004, +65 6478 8013, or Web site: http://www.affymetrix.com/

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