APRE Aprea Therapeutics Inc

CUSIP No. 03836J102

1

Name of Reporting Person
KDev Investments AB

2

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3

SEC Use Only

4

Citizenship or Place of Organization
Sweden

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0

6

Shared Voting Power
2,444,837 (1)

7

Sole Dispositive Power
0

8

Shared Dispositive Power
2,444,837 (1)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
2,444,837 (1)

10

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11

Percent of Class Represented by Amount in Row (9)
11.6% (2)

12

Type of Reporting Person (See Instructions)
OO

CUSIP No. 03836J102

1

Name of Reporting Person
Karolinska Development AB

2

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3

SEC Use Only

4

Citizenship or Place of Organization
Sweden

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0

6

Shared Voting Power
2,444,837 (1)

7

Sole Dispositive Power
0

8

Shared Dispositive Power
2,444,837 (1)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
2,444,837 (1)

10

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11

Percent of Class Represented by Amount in Row (9)
11.6% (2)

12

Type of Reporting Person (See Instructions)
OO

CUSIP No. 03836J102

1

Name of Reporting Person
KCIF Co-Investment Fund KB

2

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3

SEC Use Only

4

Citizenship or Place of Organization
Sweden

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0

6

Shared Voting Power
2,444,837 (1)

7

Sole Dispositive Power
0

8

Shared Dispositive Power
2,444,837 (1)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
2,444,837 (1)

10

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11

Percent of Class Represented by Amount in Row (9)
11.6%(2)

12

Type of Reporting Person (See Instructions)
OO

Item 1.

(a)

Name of Issuer

Aprea Therapeutics, Inc. (the “Issuer”)

(b)

Address of Issuer’s Principal Executive Offices

535 Boylston Street
Boston, MA 02116

Item 2.

(a)

Names of Persons Filing

KDev Investments AB
Karolinska Development AB
KCIF Co-Investment Fund KB

(b)

Address of Principal Business Office or, if none, Residence

KDev Investments AB
Tomtebodavägen 23A
171 65 Solna, Sweden

Karolinska Development AB
Tomtebodavägen 23A
171 65 Solna, Sweden

KCIF Co-Investment Fund KB
Tomtebodavägen 23A
171 65 Solna, Sweden

(c)

Citizenship

KDev Investments AB: Sweden
Karolinska Development AB: Sweden
KCIF Co-Investment Fund KB: Sweden

(d)

Title of Class of Securities

Common Stock, $0.001 par value

(e)

CUSIP Number

03836J102

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

o

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

(b)

o

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

(c)

o

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

(d)

o

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8);

(e)

o

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f)

o

An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g)

o

A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);

(h)

o

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

o

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

o

A non-U.S. institution in accordance with § 240.13d–1(b)(1)(ii)(J);

(k)

o

Group, in accordance with § 240.13d–1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with

§ 240.13d–1(b)(1)(ii)(J), please specify the type of institution:____________________________

Item 4.

Ownership.

(a)

Amount beneficially owned:   

KDev Investments AB — 2,444,837 (1)
Karolinska Development AB — 2,444,837 (1)
KCIF Co-Investment Fund KB — 2,444,837 (1)

(b)

Percent of class:   

KDev Investments AB — 11.6% (2)
Karolinska Development AB — 11.6% (2)
KCIF Co-Investment Fund KB — 11.6% (2)

(c)

Number of shares as to which KDev Investments AB has:

(i)

Sole power to vote or to direct the vote:   

0

(ii)

Shared power to vote or to direct the vote:    

2,444,837 (1)

(iii)

Sole power to dispose or to direct the disposition of:   

0

(iv)

Shared power to dispose or to direct the disposition of:   

2,444,837 (1)

Number of shares as to which Karolinska Development AB has:

(i)

Sole power to vote or to direct the vote:   

0

(ii)

Shared power to vote or to direct the vote:    

2,444,837 (1)

(iii)

Sole power to dispose or to direct the disposition of:   

0

(iv)

Shared power to dispose or to direct the disposition of:   

2,444,837 (1)

Number of shares as to which KCIF Co-Investment Fund KB has:

(i)

Sole power to vote or to direct the vote:   

0

(ii)

Shared power to vote or to direct the vote:    

2,444,837 (1)

(iii)

Sole power to dispose or to direct the disposition of:   

0

(iv)

Shared power to dispose or to direct the disposition of:   

2,444,837 (1)

Item 5.

Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following   o

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

N/A

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

N/A

Item 8.

Identification and Classification of Members of the Group.

N/A

Item 9.

Notice of Dissolution of Group.

N/A

Item 10.

Certifications.

N/A

Karolinska Development AB

By:

/s/ Viktor Drvota

Name: Viktor Drvota

Title: Board Director

KDev Investments AB

By: Karolinska Development AB, Majority Owner and Co-Manager

By:

/s/ Viktor Drvota

Name: Viktor Drvota

Title: Board Director

KCIF Co-Investment Fund KB

By: KCIF Fund Management AB

By:

/s/ Ulf Richenberg

Name: Ulf Richenberg

Title: Board Director