Explanation of Responses:
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1)
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Pursuant to the Agreement and Plan of Merger, dated September 5, 2013, between the Issuer, Otsuka Pharmaceutical Co. Ltd., and Autumn Aquisition Corporation (the "Merger Agreement"), each share of Common Stock was exchanged for $8.50 in cash.
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2)
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Includes 60 shares held individually by spouse and 10 shares held by spouse as custodian for their daughter under the Uniform Grant to Minors Act.
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3)
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The option provided for vesting as to 1/12th of the shares on February 1, 2005 and on each one month anniversary thereafter.
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4)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $600,000.00 which represents the difference between $8.50 and the exercise price of the option per share.
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5)
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The option provided for vesting as to 1/12th of the shares on February 1, 2006 and on each one month anniversary thereafter.
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6)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $867,500.00, which represents the difference between $8.50 and the exercise price of the option per share.
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7)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $726,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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8)
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The option provided for vesting as to 1/12th of the shares on February 1, 2007 and on each one month anniversary thereafter.
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9)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,238,400.00, which represents the difference between $8.50 and the exercise price of the option per share.
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10)
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The option provided for vesting upon the satisfaction of certain milestones as set forth in the employment agreement between the Issuer and the reporting person effective January 1, 2007. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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11)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $3,440,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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12)
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The option provided for vesting as to 1/12th of the shares on February 1, 2008 and on each one month anniversary thereafter.
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13)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,764,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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14)
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The option provided for vesting as to 1/12th of the shares on February 1, 2009 and on each one month anniversary thereafter.
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15)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $2,340,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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16)
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The option provided for vesting upon the satisfaction of certain milestones as set forth in the employment agreement between the Issuer and the reporting person effective April 1, 2009. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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17)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $8,088,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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18)
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The option provided for vesting as to 1/12th of the shares on May 1, 2010 and on each one month anniversary thereafter.
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19)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,936,800.00, which represents the difference between $8.50 and the exercise price of the option per share.
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20)
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The option provided for vesting upon the satisfaction of certain milestones as set forth in the employment agreement between the Issuer and the reporting person effective October 1, 2010. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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21)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $5,104,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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22)
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The option provided for vesting as to 1/12th of the shares on May 1, 2011 and on each one month anniversary thereafter.
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23)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,922,400.00, which represents the difference between $8.50 and the exercise price of the option per share.
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24)
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The option provided for vesting as to 1/12th of the shares on May 1, 2012 and on each one month anniversary thereafter.
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25)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $2,397,600.00, which represents the difference between $8.50 and the exercise price of the option per share.
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26)
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The option provided for vesting as to 1/12th of the shares on May 1, 2013 and on each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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27)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,414,800.00, which represents the difference between $8.50 and the exercise price of the option per share.
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