Explanation of Responses:
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1)
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Pursuant to the Agreement and Plan of Merger, dated September 5, 2013, between the Issuer, Otsuka Pharmaceutical Co. Ltd., and Autumn Aquisition Corporation (the "Merger Agreement"), each share of Common Stock was exchanged for $8.50 in cash.
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2)
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The option provided for vesting as to 1/4th of the shares on May 6, 2004 and on each three month anniversary thereafter.
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3)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $15,975.00, which represents the difference between $8.50 and the exercise price of the option per share.
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4)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $26,200.00, which represents the difference between $8.50 and the exercise price of the option per share.
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5)
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The option provided for vesting as to 1/4th of the shares on May 12, 2005 and on each three month anniversary thereafter.
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6)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $82,350.00, which represents the difference between $8.50 and the exercise price of the option per share.
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7)
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The option provided for vesting as to 1/4th of the shares on June 9, 2006 and on each three month anniversary thereafter.
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8)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $135,900.00, which represents the difference between $8.50 and the exercise price of the option per share.
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9)
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The option provided for vesting as to 1/4th of the shares on June 14, 2007 and on each three month anniversary thereafter.
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10)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $78,300.00, which represents the difference between $8.50 and the exercise price of the option per share.
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11)
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The option provided for vesting as to 1/4th of the shares on June 12, 2008 and on each three month anniversary thereafter.
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12)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $194,700.00, which represents the difference between $8.50 and the exercise price of the option per share.
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13)
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The option provided for vesting as to 1/4th of the shares on June 11, 2009 and on each three month anniversary thereafter.
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14)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $195,600.00, which represents the difference between $8.50 and the exercise price of the option per share.
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15)
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The option provided for vesting as to 1/4th of the shares on June 10, 2010 and on each three month anniversary thereafter.
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16)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $222,600.00, which represents the difference between $8.50 and the exercise price of the option per share.
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17)
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The option provided for vesting as to 1/4th of the shares on June 16, 2011 and on each three month anniversary thereafter.
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18)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $195,300.00, which represents the difference between $8.50 and the exercise price of the option per share.
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19)
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The option provided for vesting as to 1/4th of the shares on June 22, 2012 and on each three month anniversary thereafter.
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20)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $288,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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21)
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The option originally provided for vesting as to 1/4th of the shares on June 13, 2013 and on each three month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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22)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $175,500.00, which represents the difference between $8.50 and the exercise price of the option per share.
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