UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 2)*
Aytu BioPharma, Inc.
(Name of Issuer)
Common Stock, $0.0001 par value per share
(Title of Class of Securities)
054754858
(CUSIP Number)
September 30, 2024
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[X] Rule 13d-1(b)
[X] Rule 13d-1(c)
[ ] Rule 13d-1(d)
* The remainder of this cover page shall be filled out for a reporting
person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing
information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not
be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise
subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
Potential persons who are to respond to the collection of information
contained in this form are not required to respond unless the form displays a currently valid OMB control number.
| 1. | Names of Reporting Persons.
Stonepine Capital Management, LLC |
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ______
(b) X |
3. SEC Use Only
| 4. | Citizenship or Place of Organization Delaware |
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With: |
5. Sole Voting Power 0
|
6. Shared Voting Power 626,862
|
7. Sole Dispositive Power 0 |
8. Shared Dispositive Power 626,862 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person 626,862 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions) ______ |
| 11. | Percent of Class Represented by Amount in Row (9) 9.99% |
| 12. | Type of Reporting Person (See Instructions) IA, OO |
| 1. | Names of Reporting Persons.
Stonepine Capital, L.P. |
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ______
(b) X |
3. SEC Use Only
| 4. | Citizenship or Place of Organization Delaware |
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With: |
5. Sole Voting Power 0
|
6. Shared Voting Power 626,862
|
7. Sole Dispositive Power 0 |
8. Shared Dispositive Power 626,862 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person 626,862 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions) ______ |
| 11. | Percent of Class Represented by Amount in Row (9) 9.99% |
| 12. | Type of Reporting Person (See Instructions) PN |
| 1. | Names of Reporting Persons.
Stonepine GP, LLC |
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ______
(b) X |
3. SEC Use Only
| 4. | Citizenship or Place of Organization Delaware |
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With: |
5. Sole Voting Power 0
|
6. Shared Voting Power 626,862
|
7. Sole Dispositive Power 0 |
8. Shared Dispositive Power 626,862 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person 626,862 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions) ______ |
| 11. | Percent of Class Represented by Amount in Row (9) 9.99% |
| 12. | Type of Reporting Person (See Instructions) OO |
| 1. | Names of Reporting Persons.
Jon M. Plexico |
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ______
(b) X |
3. SEC Use Only
| 4. | Citizenship or Place of Organization U.S.A. |
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With: |
5. Sole Voting Power 0
|
6. Shared Voting Power 626,862
|
7. Sole Dispositive Power 0 |
8. Shared Dispositive Power 626,862 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person 626,862 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions) ______ |
| 11. | Percent of Class Represented by Amount in Row (9) 9.99% |
| 12. | Type of Reporting Person (See Instructions) HC, IN |
Item 1.
| (a) | Name of Issuer
Aytu BioPharma, Inc.
|
| (b) | Address of Issuer’s Principal Executive Offices
7900 East Union Avenue, Suite 920, Denver, CO 80237 |
Item 2.
| (a) | The names of the persons filing this statement are:
|
Stonepine Capital Management, LLC, a Delaware
limited liability company (“Stonepine”)
Stonepine Capital, L.P., a Delaware limited
partnership (the “Partnership”)
Stonepine GP, LLC, a Delaware limited
liability company (the “General Partner”)
Jon M. Plexico (collectively, the “Filers”)
Stonepine and the General Partner are the investment
adviser and general partner, respectively, of the Partnership. Mr. Plexico is the control person of Stonepine and the General Partner.
The Filers are filing this Schedule 13G jointly, but not as members of a group, and each disclaims membership in a group. Each Filer also
disclaims beneficial ownership of the Stock except to the extent of that person’s pecuniary interest therein. In addition, the filing
of this Schedule 13G on behalf of the Partnership should not be construed as an admission that it is, and it disclaims that it is, a beneficial
owner, as defined in Rule 13d-3 under the Act, of any of the Stock covered by this Schedule 13G.
| (b) | The principal business office of the Filers is located at |
919 NW Bond Street, Suite 204
Bend, OR 97703
| (c) | For citizenship of Filers, see Item 4 of the cover sheet for each Filer. |
| (d) | This statement relates to the Issuer’s Common Stock, $0.0001 par value per share (the “Stock”). |
| (e) | The CUSIP number of the Issuer is: 054754858 |
| Item 3. | If this statement is filed pursuant to rule 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a: |
| (a) | [ ] Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o). |
| (b) | [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c). |
| (c) | [ ] Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c). |
| (d) | [ ] Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). |
| (e) | [X] An investment adviser in accordance with section 240.13d-1(b)(1)(ii)(E). As to Stonepine and the General Partner. |
| (f) | [ ] An employee benefit plan or endowment fund in accordance with section 240.13d-1(b)(1)(ii)(F). |
| (g) | [X] A parent holding company or control person in accordance with 240.13d-1(b)(1)(ii)(G). As to Mr. Plexico. |
| (h) | [ ] A savings association as defined in section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813). |
| (i) | [ ] A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company
Act of 1940 (15 U.S.C. 80a-3). |
| (j) | [ ] A non-U.S. institution in accordance with §240.13d-1(b)(ii)(J). |
| (k) | [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(K). |
If filing as a non-U.S. institution in accordance
with §240.13d-1(b)(1)(ii)(J), please specify the type of institution _______________________________________________________________.
See Items 5-9 and 11 of the cover page for each Filer.
The shares of the Stock beneficially owned by the Filers reported in this
Schedule 13G consist of (1) 500,958 shares of the Stock, (2) Prefunded Warrants to acquire 430,217 shares of the Stock, (3) Tranche A
Warrants to acquire 815,217 shares of the Stock and (4) Tranche B Warrants to acquire 815,217 shares of the Stock. The Prefunded Warrants,
the Tranche A Warrants and the Tranche B Warrants are each subject to a 9.99% beneficial ownership limitation. The percentages reported
in this Schedule 13G are based on 6,148,993 shares of the Stock outstanding as of September 16, 2024, as reported in the Form 10-K filed
by the Issuer on September 26, 2024.
| Item 5. | Ownership of Five Percent or Less of a Class |
If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following
[ ].
| Item 6. | Ownership of More than Five Percent on Behalf of Another Person. |
The Partnership holds the Stock for the benefit of its investors and has
the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Stock.
| Item 7. | Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. |
Not applicable.
| Item 8. | Identification and Classification of Members of the Group. |
Not applicable.
| Item 9. | Notice of Dissolution of Group |
Not applicable.
|
Item 10. | Material to Be Filed as Exhibits |
Agreement Regarding Joint Filing of Statement on Schedule 13D or
13G.
| Item 11. | Certification of Stonepine, the General Partner and Mr. Plexico |
By signing below I certify that, to the best of my knowledge
and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are
not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely
in connection with a nomination under § 240.14a-11.
Certification of the Partnership
By signing below I certify that, to the best of my knowledge
and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing
the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction
having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and correct.
Dated: November 13, 2024
|
STONEPINE CAPITAL MANAGEMENT, LLC
By: /s/ Jon M. Plexico
Jon M. Plexico
Managing Member
|
|
|
STONEPINE CAPITAL, L.P.
By: Stonepine GP, LLC,
General Partner
By: /s/ Jon M. Plexico
Jon M. Plexico
Managing Member
|
|
|
STONEPINE GP, LLC
By: /s/ Jon M. Plexico
Jon M. Plexico
Managing Member
|
|
|
/s/ Jon M. Plexico
Jon M. Plexico |
|
EXHIBIT A
AGREEMENT REGARDING JOINT FILING
OF STATEMENT ON SCHEDULE 13D OR 13G
The undersigned agree to file jointly with the Securities
and Exchange Commission (the “SEC”) any and all statements on Schedule 13D or Schedule 13G or Forms 3, 4 or 5(and any amendments
or supplements thereto) required under section 13(d) and 16(a) of the Securities Exchange Act of 1934, as amended, in connection with
purchases by the undersigned of the securities of any issuer. For that purpose, the undersigned hereby constitute and appoint Stonepine
Capital Management, LLC, a Delaware limited liability company, as their true and lawful agent and attorney-in-fact, with full power and
authority for and on behalf of the undersigned to prepare or cause to be prepared, sign, file with the SEC and furnish to any other person
all certificates, instruments, agreements and documents necessary to comply with section 13(d) and section 16(a) of the Securities Exchange
Act of 1934, as amended, in connection with said purchases, and to do and perform every act necessary and proper to be done incident to
the exercise of the foregoing power, as fully as the undersigned might or could do if personally present.
Dated: October 10, 2024
|
STONEPINE CAPITAL MANAGEMENT, LLC
By: /s/ Jon M. Plexico
Jon M. Plexico
Managing Member
|
|
STONEPINE CAPITAL, L.P.
By: Stonepine GP, LLC,
General Partner
By: /s/ Jon M. Plexico
Jon M. Plexico
Managing Member
|
|
STONEPINE GP, LLC
By: /s/ Jon M. Plexico
Jon M. Plexico
Managing Member
|
|
/s/ Jon M. Plexico
Jon M. Plexico |
|
|
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