Bruker Daltonics Introduces Advanced Solution for Quantitative Proteomics at ASMS 2005; Quantitative Proteomics for TOF/TOF and
June 06 2005 - 7:00AM
Business Wire
Bruker Daltonics Inc. today announces Proteineer-LC 1.1, a unique
LC-MS/MS-based quantitative proteomics solution, and the new
ProteinScape 1.3 release of its bioinformatics software. Stable
Isotope Labeling Experiments (SILE) such as ICAT(TM), the more
recently introduced ICPL(TM) technology, or even user-defined
isotopic labels are fully supported in the new software releases.
The Proteineer software suite extends the existing workflow support
from 2D gel to LC-MS/MS based protein identification and
quantitation using Bruker Daltonics' Ultraflex II MALDI-TOF/TOF and
HCTultra ion trap mass spectrometers. Proteineer-LC 1.1 now
provides the quantitative information associated with protein
identification to deliver the desired biological insights. As
complex protein mixtures are analysed more and more in depth, there
is a demand for proteome analyses of increasing numbers of
fractions. The resulting very large amounts of data require
database solutions that merge the information and provide powerful
data validation tools. ProteinScape(TM) software, co-developed with
Protagen AG, integrates all major search engines including
Mascot(TM), Phenyx(TM) and Profound(TM). The unique MetaScore(TM)
algorithm combines the results from these search engines to
increase information readout. The unique ProteinExtractor(TM)
algorithm generates true non-redundant protein lists from LC-MS/MS
search results. Both algorithms reduce manual validation efforts
significantly. For in-depth analysis, more detailed protein
sequence and modification interpretation is provided by the
fully-integrated BioTools(TM) protein analysis software for
interactive data validation and discovery: PTM and mutation
screening, or de novo sequencing combined with homology searches
allow the extraction of more information based on sequence
annotated data. LC-MALDI utilizes Bruker Daltonics' disposable
Prespotted AnchorChips(TM) for highest sensitivity, elimination of
interfering memory effects and ultimate spot-to-spot quantitation
reproducibility. The unique Proteineer-LC 1.1 combination of
LC-ESI-MALDI into a single workflow, allows scientists to validate
and complement LC-ESI-MS/MS results with LC-MALDI-TOF/TOF data. The
new Proteineer-LC 1.1 Survey Viewer(TM) provides a new level of
interactive LC-MS and MS/MS data evaluation. Prof. Dr. Helmut E.
Meyer from the Medical Proteome Centre of the University of Bochum,
Germany and Coordinator of the HUPO Brain Proteome Project (HBPP)
said: "ProteinScape is already used by the HBPP research groups
around the globe. We are happy to see that a great number of
proteomics workflows are now manageable under ProteinScape 1.3.
Within HBPP, we routinely share data from entire projects within
our research network on this bioinformatics platform. This enables
us to build a data collection centre providing proteomics data to
the scientific community via EBI's PRIDE database." Professor Dr.
Herbert Thiele, Director of Bioinformatics at Bruker Daltonics,
added: "We believe the increased functionality and algorithms of
our new software suite give researchers options they have been
looking for. We have collaborated with the HUPO Proteomics
Standards Initiative (PSI) since its inception to define community
standards for data representation in proteomics, and we fully
support the mzData standard in ProteinScape 1.3." PROTEINEER-LC 1.1
will be presented in scientific contributions from Bruker Daltonics
during the 53rd ASMS conference on Mass Spectrometry in San
Antonio, Texas this week. ICAT is a trademark of the University of
Washington, ICPL is a trademark of TopLab, Mascot is a trademark of
Matrix Science, Phenyx is a trademark of GeneBio, Profound is a
trademark of Genomics Solutions, all other trademarks are owned by
Bruker Daltonics. ABOUT BRUKER BIOSCIENCES (NASDAQ: BRKR) Bruker
BioSciences Corporation, headquartered in Billerica, Massachusetts,
is the publicly traded parent company of Bruker Daltonics Inc. and
Bruker AXS Inc. Bruker AXS is a leading developer and provider of
life science and advanced materials research tools based on x-ray
technology. Bruker Daltonics is a leading developer and provider of
innovative life science tools based on mass spectrometry. Bruker
Daltonics also offers a broad line of nuclear, biological and
chemical (NBC) detection systems for homeland security. For more
information: www.bruker-biosciences.com CAUTIONARY STATEMENT OF
BRUKER BIOSCIENCES Any statements contained in this press release
that do not describe historical facts may constitute
forward-looking statements as that term is defined in the Private
Securities Litigation Reform Act of 1995. Any forward-looking
statements contained herein are based on current expectations, but
are subject to a number of risks and uncertainties. The factors
that could cause actual future results to differ materially from
current expectations include, but are not limited to, risks and
uncertainties relating to the Company's reorganization strategies,
integration risks, failure of conditions, technological approaches,
product development, market acceptance, cost and pricing of the
Company's products, changes in governmental regulations, capital
spending and government funding policies, FDA and other regulatory
approvals to the extent applicable, competition, the intellectual
property of others, patent protection and litigation. These and
other factors are identified and described in more detail in our
filings with the SEC, including, without limitation, our annual
report on Form 10-K for the year ended December 31, 2004, our most
recent quarterly reports on Form 10-Q and our current reports on
Form 8-K. We disclaim any intent or obligation to update these
forward-looking statements.
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