Bruker BioSpin 1.7mm MicroCryoProbe(TM) Wins R&D 100 Award for Delivering a Tenfold Jump in NMR Sensitivity for Small Sample Amo
July 23 2008 - 1:15PM
Business Wire
A 2008 R&D 100 Award has been presented to Bruker BioSpin for
its 1.7mm triple resonance NMR MicroCryoProbe� with breakthrough
sensitivity on an active volume of only 30 microliters. The 1.7mm
MicroCryoProbe� together with the MRI CryoProbe� are two
innovations from Bruker BioSpin selected by the independent judging
panel and editors of R&D Magazine in 2008 for this prestigious
award. This novel MicroCryoProbe� offers an increase in mass
sensitivity of more than an order of magnitude, which makes the 1.7
mm MicroCryoProbe� an ideal tool for any Nuclear Magnetic Resonance
(NMR) analysis with limited sample amounts, e.g. natural products,
drug metabolites, isolated low abundance proteins, peptides or
small molecules, or difficult-to-express proteins. Conventional
room-temperature NMR microprobes with 5 and 30 micro liter volumes
have become popular in areas such as natural products chemistry,
drug metabolism, protein NMR and drug screening applications. The
introduction of a cryogenically cooled MicroCryoProbe� is of
significant importance for researchers working with very limited
sample quantities, e.g. natural products isolated in minute
quantities from a variety of organisms, or protein samples that
have been prepared in small scale expression systems. The
significant increase in sensitivity is achieved by cryogenically
cooling both detection coil and preamplifier together with
proprietary high-sensitivity electronics design. For a given sample
amount, a 6-fold gain over a conventional 1.7�mm microprobe and
about a 10-14-fold gain over a conventional 5�mm probe are
obtained. This can lead to a 200-fold reduction in experiment time,
or alternatively it fundamentally enables NMR research with very
low sample quantities that previously would simply not have been
possible or practical. �Bruker�s MicroCryoProbe� offers incredible
mass sensitivity, and enables us to obtain data on natural product
sample obtained�from a single sea mollusc that we collected 15
years ago but were unable to acquire NMR data on because of
insufficient sample amount. Now with the 1.7mm MicroCryoProbe�
we've solved the structures of these molecules,� said Ted Molinski,
Professor at the Skaggs School of Pharmacy and Pharmaceutical
Sciences at University of California San Diego. �Many of our
customers have urged us to develop a MicroCryoProbe�,� said
Mr.�Oskar Schett, a Managing Director of Bruker BioSpin. �It was
clear that after the successes of both our 5mm CryoProbes and our
conventional microprobes a combination of the two technologies was
the next logical step to further lower the detection limits of NMR
for the characterization of many samples that were considered not
measurable by NMR�. ABOUT BRUKER BIOSPIN: For more information
about Bruker BioSpin and Bruker Corporation (NASDAQ: BRKR), please
visit www.bruker-biospin.com and www.bruker.com.
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