Bruker Launches solariX™ FTMS Based MALDI System at ASMS Conference
May 23 2010 - 7:00AM
Business Wire
At the 58th ASMS Conference on Mass Spectrometry and Allied
Topics, Bruker today announces a novel MALDI molecular imaging
system based on the extreme performance of the solariX FTMS.
The new MALDI-solariX combines the extreme analytical
performance of the solariX FTMS (resolving power >
1,000,000 at m/z 400 at 7.0 tesla field strength) with a robust and
highly sensitive MALDI source to provide an unrivalled platform for
high performance molecular imaging of small molecules (e.g. drug,
metabolites, lipids) in tissue.
The new solariX MALDI source is based on a dual ion
funnel design that includes the combination of MALDI and
ESI. This unique source is capable of immediate and effortless
switching between the two ionization methods. The combination of
MALDI with the solariX FTMS addresses a need in the
pharmaceutical industry and in academic research institutions for a
high performance imaging solution targeted specifically to the
tissue distribution of small molecule drugs and metabolites,
endogenous metabolic spatial profiling, and lipid imaging.
The solariX MALDI system incorporates the innovative,
proprietary smartbeamTM II laser which
includes a robust solid state 1 kHz laser with advanced optics for
molecular imaging, for:
- Ultra-high mass resolution
high-sensitivity small molecule MALDI-MS imaging, without a loss in
sensitivity due to MS/MS for selectivity
- Sensitivity necessary to detect
drugs and metabolites at therapeutic dosages
- Fast data acquisition of up to 1
pixel/sec with 1 kHz laser speed
- Laser spot sizes down to 20 um
allowing high spatial resolution
- Instantaneous source switching
allowing trouble free changeover from ESI to MALDI
- Highly effective workflow
including MALDI imaging sample preparation with the Bruker
ImagePrep™ station and data acquisition / image processing
with FlexImaging™ software
- First commercially available
software solution for small molecule statistical class imaging
utilizing ClinProTools™
By combining molecular imaging with FTMS detection, researchers
can utilize ultra-high mass resolving power to separate and analyze
molecules of closely related masses in a truly multiplexed approach
– observing all molecular species simultaneously. This provides
selectivity without compromising sensitivity. Additionally,
industry-leading high mass accuracy (< 1 ppm) provides the
requisite specificity for elucidating molecular species without the
need for time consuming MS/MS. Complete, simultaneous, label-free
mapping of drugs and metabolites in tissue can now be conveyed from
single MALDI imaging runs at therapeutic dosing levels. For
complete confidence in molecular assignment of detected masses,
Bruker’s SmartFormula™ software can be used as part of the
small molecule imaging workflow for assigning unambiguous elemental
formula to detected peaks.
David Wagner, Section Manager of the DMPK group for
GlaxoSmithKline, remarked: "We are very excited to be adding this
state-of-the-art capability to the analytical analysis portfolio of
our group. This instrument will serve as the primary
high-performance molecular imaging solution for GSK's development
efforts, and will provide unprecedented power for the spatial
analysis of target metabolites."
Full automation allows researchers to acquire data in a
completely unattended fashion and the unprecedented ease-of-use
offered by the solariX FTMS means MALDI data acquisition and
imaging workflows require minimal operator effort.
The solariX™ FTMS Based MALDI System will be
highlighted at Bruker's Users Meeting on Sunday, May 23rd, 2010
before the 58th ASMS Conference on Mass Spectrometry in Salt Lake
City, Utah (USA). For more information on Bruker’s User Meeting and
other ASMS activities, please visit www.bdal.com/asms2010.
For More Information:
For more information on the solariX™ FTMS Based MALDI
System please visit www.bdal.com/solarix
For information about Bruker Daltonics and Bruker Corporation
(NASDAQ: BRKR), please visit www.bruker.com
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