Bruker Announces Release of Breakthrough CaptiveSpray™ Nano/Capillary Electrospray Ion Source for Proteomics at ASMS 2011
June 06 2011 - 7:00AM
Business Wire
At ASMS 2011, Bruker is introducing the breakthrough,
proprietary CaptiveSpray electrospray ion source for
nano-HPLC applications in proteomics. Using CaptiveSpray
technology in many cases increases bottom-up protein
identifications significantly, and CaptiveSpray is presently
the best available technology for robust, reproducible protein ID
or quantitative proteomics applications, with excellent, stable
sensitivity over long time periods.
CaptiveSpray LC-MS Source (Photo:
Business Wire)
Unlike a traditional pulled nanospray tip, the
Etch-TaperTM technology employed by
CaptiveSpray ensures that the internal diameter of the spray
tip remains constant, thereby reducing tip clogging, and providing
excellent spray stability over the entire LC gradient and robust
operation for long time periods, even with heavy proteomics samples
loads. A key proprietary feature of the CaptiveSpray is its
novel gas-flow focusing technology for dramatic sensitivity gains
compared to normal electrospray. The CaptiveSpray source
delivers nanospray sensitivity without the need for complex and
time consuming spray tip adjustments, while its innovative
plug-and-play design fits all current Bruker LC-MS instruments,
including the latest maXis UHR-Qq-TOF systems,
solariX FTMS systems and amaZon ETD ion trap mass
spectrometers.
The novel CaptiveSpray source is uniquely designed to
operate with LC flow rates from as low as 50 nL/min up to 5 uL/min
and higher. This wide LC flow range allows analysts to
significantly reduce column loading times, minimize column
re-equilibration, and dramatically increase overall MS utilization
time. The ability to run at higher LC flow rates, without
compromising sensitivity, also increases sample loading capacity
and expands the dynamic range of analysis. This combination of
attributes provided by the unique CaptiveSpray source
enhances the overall ability of the MS system to identify and
quantify low-level peptides.
Dr. Kerry Nugent, Senior Vice President for Liquid
Chromatography at Bruker’s Chemical & Applied Markets Division,
commented: “With the introduction of the CaptiveSpray ion
source, Bruker has taken another step to enhance our leadership
position in proteomics. The ability of the CaptiveSpray
source to deliver a robust consistent spray, regardless of gradient
composition or flow rate, makes it the ideal high-sensitivity MS
source for applications that require a high level of accuracy and
precision, such as bottom-up proteomics, peptide ID and protein
quantification.”
For More Information:
For more information on CaptiveSpray and Bruker Daltonics
please visit
http://www.bdal.de/products/lc-ms/ion-sources/captivespray/overview.
For information about Bruker Corporation (NASDAQ: BRKR), please
visit www.bruker.com.
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