Bruker Introduces High Definition (HD) & the revolutionary NMR Thermometer™ to NMR with the Most Sensitive, Accurate, High ...
April 16 2012 - 7:00AM
Business Wire
At the Experimental Nuclear Magnetic Resonance Conference (ENC)
2012, Bruker introduces the novel AVANCE III HD NMR
spectrometer. Thanks to its new digital RF synthesizer, further
enhanced receiver electronics, redesigned preamplifiers, extended
Digital Lock™ and SmartVT™ capabilities, Bruker now has further
enhanced the most sensitive and most accurate, highest performance
NMR spectrometer on the market today, bringing High Definition (HD)
technology to AVANCE NMR users.
AVANCE III HD 600 NMR system (Photo:
Business Wire)
The AVANCE III HD spectrometer benefits from a
next-generation RF synthesizer with significantly increased digital
integration, incorporating a lower phase noise local oscillator
(LO) and a high speed DA converter running at 960 MHz. This enables
extended digital RF power settings up to NMR frequencies of
1.2 GHz. Together with the new high dynamic range and high
sensitivity preamplifiers, the AVANCE III HD demonstrates
improved spectral purity, fully exploits the increased sensitivity
of the latest NMR probe technology and enables sensitivity
improvements of up to 30% for the most demanding applications.
These include experiments on bio-molecular samples in buffers or
detergents, metabolic beverage analysis for food safety and
quality, and trace analysis such as impurity detection in drugs and
other pharmaceutical compounds.
With the new AVANCE III HD preamplifiers and the new GaAs
FET-based broad-band technology, solid-state NMR applications in
particular will directly benefit from up to a 20% increase in
sensitivity on 13C and other X nuclei. A novel impedance matching
technology ensures solids spectra with excellent symmetry, and the
active, fast high power transmit/receive switch guarantees maximum
linearity even at the lowest power levels. The AVANCE III HD
now provides solid-state NMR researchers with access to fully
broad-banded capacities and easier daily routine operation without
the need for manual interaction. A touch-screen display enables
high-definition tuning and matching of the system and monitoring of
the probe status.
With the revolutionary NMR Thermometer™ for the first
time, the measurement of the exact internal sample temperature by
NMR itself is possible. This is achieved fully automatically
through the measurement of the chemical shift difference between
two deuterium resonances, rather than relying on inaccurate
external thermocouples. While one deuterium signal is used for
field stabilization, the chemical shift difference to the second
signal is used together with the SmartVT™ to both measure and
maintain a constant temperature within the sample. Based on the
measurement of the actual sample temperature, the NMR
Thermometer™ now offers the possibility of up to 50% times
faster on-line regulation of sample temperature, more efficient
compensation for heating effects caused by RF pulse sequences, or
by sample spinning in MAS experiments. This results in an immediate
improvement in the accuracy and precision of the acquired signal
frequencies by up to a factor 5, delivering improved accuracy in
the assignment of resonances, especially in solid-state, and
2D/3D/4D protein and biomolecular NMR applications.
“With our unsurpassed commitment to innovation and to bringing
the latest technology to the field of NMR, the new AVANCE III
HD spectrometer once again offers enabling R&D innovations
and performance breakthroughs from our R&D centers and key
customer collaborations to all NMR customers,” said Dr. Frank
Laukien, Bruker’s President and CEO.
About Bruker Corporation
Bruker Corporation is a leading provider of high-performance
scientific instruments and solutions for molecular and materials
research, as well as for industrial and applied analysis. For more
information about Bruker Corporation (NASDAQ: BRKR), please visit
www.bruker.com
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