FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Breen Michael Martin
2. Issuer Name and Ticker or Trading Symbol

GT Biopharma, Inc. [ GTBP ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)

C/O GT BIOPHARMA, INC, 9350 WILSHIRE BLVD., STE. 203
3. Date of Earliest Transaction (MM/DD/YYYY)

2/16/2021
(Street)

BEVERLY HILLS, CA 90212
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 2/16/2021  A  278058 (1)A$0.00 278058 D  
Common Stock 2/25/2021  C  40243 A$3.40 318301 D  
Common Stock 2/25/2021  C  9859 A$3.40 328160 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Option to purchase Common Stock $6.33 2/16/2021  A   50000     (2)2/15/2031 Common Stock 50000 $0.00 50000 D  
10% Senior Convertible Debenture $3.40 2/25/2021  C     100000  9/7/2018  (3)Common Stock 40243 $0 0 D  
10% Senior Convertible Debenture $3.40 2/25/2021  C     30000  6/23/2020 6/23/2021 Common Stock 9859 $0 0 D  

Explanation of Responses:
(1) Represents a grant of shares of restricted stock ("RSAs"). 1/3rd of the RSAs vest on January 13, 2021, 2022 and 2023.
(2) 1/3rd of the shares vest on February 16, 2021, 2022 and 2023.
(3) While the maturity date of the Debenture was September 7, 2019, the Registrant did not repay the Debenture on the maturity date and the Debenture remained outstanding until converted.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Breen Michael Martin
C/O GT BIOPHARMA, INC
9350 WILSHIRE BLVD., STE. 203
BEVERLY HILLS, CA 90212
X



Signatures
/s/ Michael Martin Bree11/9/2021
**Signature of Reporting PersonDate

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