FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Bryce Joanne
2. Date of Event Requiring Statement (MM/DD/YYYY)
12/29/2022 

3. Issuer Name and Ticker or Trading Symbol

Disc Medicine, Inc. [IRON]
(Last)        (First)        (Middle)

C/O DISC MEDICINE, INC., 321 ARSENAL STREET, SUITE 101
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Chief Financial Officer /
(Street)

WATERTOWN, MA 02472      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 3452 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)  (1)11/5/2029 Common Stock 8406 $1.01 D  
Stock Option (Right to Buy)  (2)11/5/2029 Common Stock 6028 $1.01 D  
Stock Option (Right to Buy)  (3)10/22/2030 Common Stock 4753 $2.65 D  
Stock Option (Right to Buy)  (4)10/22/2030 Common Stock 4753 $2.65 D  
Stock Option (Right to Buy)  (5)9/13/2031 Common Stock 79245 $9.86 D  

Explanation of Responses:
(1) The shares underlying this option vest in 16 equal quarterly installments following September 13, 2019, subject to the Reporting Person's continued service on each such vesting date.
(2) The shares underlying this option vest in 16 equal quarterly installments following May 1, 2020, subject to the Reporting Person's continued service on each such vesting date.
(3) The shares underlying this option vest in 48 equal monthly installments following January 1, 2020, subject to the Reporting Person's continued service on each such vesting date.
(4) The shares underlying this option vest in 48 equal monthly installments following October 7, 2020, subject to the Reporting Person's continued service on each such vesting date.
(5) The shares underlying this option vest in 48 equal monthly installments following September 1, 2021, subject to the Reporting Person's continued service on each such vesting date.

Remarks:
Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Bryce Joanne
C/O DISC MEDICINE, INC.
321 ARSENAL STREET, SUITE 101
WATERTOWN, MA 02472


Chief Financial Officer

Signatures
/s/ Rahul Khara, attorney-in-fact1/3/2023
**Signature of Reporting PersonDate


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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