FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Quisel John D		 2. Date of Event Requiring Statement (MM/DD/YYYY)
12/29/2022 

 3. Issuer Name and Ticker or Trading Symbol

Disc Medicine, Inc. [IRON]
(Last)        (First)        (Middle)

C/O DISC MEDICINE, INC., 321 ARSENAL STREET, SUITE 101		 4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Chief Executive Officer /
(Street)

WATERTOWN, MA 02472      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		2. Amount of Securities Beneficially Owned
(Instr. 4)		3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)		2. Date Exercisable and Expiration Date
(MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)  (1)3/10/2030 Common Stock 243911 $1.01 D  
Stock Option (Right to Buy)  (2)10/22/2030 Common Stock 61650 $2.65 D  
Stock Option (Right to Buy)  (3)9/13/2031 Common Stock 168387 $9.86 D  
Explanation of Responses:
(1) 25% of the shares underlying this option vested on February 25, 2021, with the remaining shares vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.
(2) 5,137 shares underlying this option vested on February 25, 2021, with the remaining shares vesting in 44 equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.
(3) The shares underlying this option vest in 48 equal monthly installments following September 1, 2021, subject to the Reporting Person's continued service on each such vesting date.

Remarks:
Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Quisel John D
C/O DISC MEDICINE, INC.
321 ARSENAL STREET, SUITE 101
WATERTOWN, MA 02472		X
Chief Executive Officer
Signatures
/s/ Rahul Khara, attorney-in-fact1/3/2023
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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