UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

NOTICE OF EFFECTIVENESS

Effective Date: May 16, 2011
Accession Number: 0000895345-11-000186
Submission Type: POS AM
CIK: 0001040416
Company Name: INSPIRE PHARMACEUTICALS INC
File Number: 333-147733
Inspire Pharmaceuticals, Inc. (MM) (NASDAQ:ISPH)
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