CUSIP No: 74638P109
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS
FILED PURSUANT
TO § 240.13d-1(b), (c) AND (d) AND
AMENDMENTS THERETO FILED
PURSUANT TO § 240.13d-2.
(Amendment No. 1)*
Purple
Biotech Ltd. (formerly Kitov Pharma Ltd.)
(Name of Issuer)
Ordinary Shares, no par value
(Title of Class of Securities)
74638P109
(CUSIP Number)
December 31, 2020
(Date of Event Which Requires Filing of
this statement)
Check the appropriate box to designate
the rule pursuant to which this Schedule is filed:
¨ Rule 13d-1(b)
x Rule 13d-1(c)
¨ Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a
reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder
of this cover page shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934
(“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).
CUSIP No: 74638P109
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(1)
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NAMES OF REPORTING PERSONS
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CVI Investments, Inc.
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(2)
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
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(SEE INSTRUCTIONS)
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(a) ¨
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(b) ¨
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(3)
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SEC USE ONLY
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(4)
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CITIZENSHIP OR PLACE OF ORGANIZATION
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Cayman Islands
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NUMBER OF
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(5)
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SOLE VOTING POWER
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SHARES
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0
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BENEFICIALLY
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(6)
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SHARED VOTING POWER **
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OWNED BY
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1,348,889
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EACH
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(7)
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SOLE DISPOSITIVE POWER
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REPORTING
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0
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PERSON WITH
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(8)
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SHARED DISPOSITIVE POWER **
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1,348,889
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(9)
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
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1,348,889
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(10)
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CHECK BOX IF THE AGGREGATE AMOUNT
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IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
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¨
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(11)
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
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0.8%
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(12)
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TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
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CO
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** Heights Capital Management, Inc. is the investment manager
to CVI Investments, Inc. and as such may exercise voting and dispositive power over these shares.
CUSIP No: 74638P109
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(1)
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NAMES OF REPORTING PERSONS
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Heights Capital Management, Inc.
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(2)
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
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(SEE INSTRUCTIONS)
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(a) ¨
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(b) ¨
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(3)
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SEC USE ONLY
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(4)
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CITIZENSHIP OR PLACE OF ORGANIZATION
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Delaware
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NUMBER OF
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(5)
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SOLE VOTING POWER
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SHARES
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0
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BENEFICIALLY
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(6)
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SHARED VOTING POWER **
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OWNED BY
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1,348,889
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EACH
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(7)
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SOLE DISPOSITIVE POWER
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REPORTING
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0
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PERSON WITH
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(8)
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SHARED DISPOSITIVE POWER **
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1,348,889
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(9)
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
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1,348,889
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(10)
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CHECK BOX IF THE AGGREGATE AMOUNT
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IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
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¨
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(11)
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
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0.8%
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(12)
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TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
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CO
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** Heights Capital Management, Inc. is the investment manager
to CVI Investments, Inc. and as such may exercise voting and dispositive power over these shares.
CUSIP No: 74638P109
Item 1.
Purple Biotech Ltd. (formerly Kitov Pharma
Ltd.)(the “Company”)
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(b)
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Address of Issuer’s Principal Executive Offices
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4 Oppenheimer Street, Science Park, Rehovot 7670104,
Israel
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Item 2(a).
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Name of Person Filing
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This statement is filed by the entities listed below,
who are collectively referred to herein as “Reporting Persons,” with respect to the ordinary shares of the Company,
no par value (the “Shares”).
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(i)
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CVI Investments, Inc.
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(ii)
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Heights Capital Management, Inc.
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Item 2(b).
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Address of Principal Business Office or, if none, Residence
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The address of the principal business office of CVI
Investments, Inc. is:
P.O. Box 309GT
Ugland House
South Church Street
George Town
Grand Cayman
KY1-1104
Cayman Islands
The address of the principal business office of Heights
Capital Management, Inc. is:
101 California Street, Suite 3250
San Francisco, California 94111
Citizenship is set forth in Row 4 of the cover page
for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person.
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Item 2(d)
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Title of Class of Securities
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Ordinary shares, no par value
74638P109 The
CUSIP Number applies to the American Depositary Shares, each of which represents one (1) Share.
CUSIP No: 74638P109
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Item 3.
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If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is
a:
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(a)
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Broker
or dealer registered under Section 15 of the Act (15 U.S.C. 78o).
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(b)
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¨
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Bank
as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).
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(c)
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¨
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Insurance
company as defined in Section 3(a)(19) of the Act (15 U.S.C. 78c).
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(d)
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¨
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Investment
company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
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(e)
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¨
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An
investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
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(f)
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¨
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An
employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
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(g)
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¨
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A
parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);
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(h)
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¨
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A
savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
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(i)
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¨
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A
church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company
Act of 1940 (15 U.S.C. 80a-3);
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(j)
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A non-U.S.
institution in accordance with §240.13d-1(b)(1)(ii)(J);
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(k)
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Group,
in accordance with Rule 13d-1(b)(1)(ii)(K).
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If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J),
please specify the type of institution: ________________
Provide the following information regarding
the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
The information required by Items 4(a) – (c)
is set forth in Rows 5 – 11 of the cover page for each Reporting Person hereto and is incorporated herein by reference for
each such Reporting Person.
The number of Shares reported as beneficially owned
consists of Shares (represented by American Depositary Shares) issuable upon the exercise of warrants to purchase American Depositary
Shares.
The Company’s Proxy Statement, filed on October
22, 2020, indicates there were 172,105,742 Shares outstanding as of October 20, 2020.
Heights Capital Management, Inc., which serves as
the investment manager to CVI Investments, Inc., may be deemed to be the beneficial owner of all Shares owned by CVI Investments,
Inc. Each of the Reporting Persons hereby disclaims any beneficial ownership of any such Shares, except for their pecuniary interest
therein.
CUSIP No: 74638P109
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Item 5.
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Ownership of Five Percent or Less of a Class
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If
this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial
owner of more than five percent of the class of securities, check the following: [x]
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Item 6.
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Ownership of More than Five Percent on Behalf of Another Person
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Not applicable.
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Item 7.
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Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company
or Control Person
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Not applicable.
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Item 8.
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Identification and Classification of Members of the Group
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Not applicable.
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Item 9.
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Notice of Dissolution of Group
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Not applicable.
By signing below each of the undersigned
certifies that, to the best of its knowledge and belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction having that purpose or effect.
CUSIP No: 74638P109
SIGNATURES
After reasonable inquiry and to the
best of its knowledge and belief, each of the undersigned certifies that the information with respect to it set forth in this
statement is true, complete, and correct.
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Dated: February 10, 2021
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CVI INVESTMENTS, INC.
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HEIGHTS CAPITAL MANAGEMENT, INC.
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By: Heights Capital Management, Inc.
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By:
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/s/ Brian Sopinsky
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pursuant to a Limited
Power of
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Name: Brian Sopinsky
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Attorney, a copy of which was
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Title: Secretary
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previously filed
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By:
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/s/ Brian Sopinsky
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Name: Brian Sopinsky
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Title: Secretary
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CUSIP No: 74638P109
EXHIBIT INDEX
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EXHIBIT
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DESCRIPTION
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I
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Limited Power of Attorney*
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II
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Joint Filing Agreement*
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*Previously filed