UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

NOTICE OF EFFECTIVENESS

Effective Date: February 21, 2019
Accession Number: 0001193125-19-042490
Submission Type: POS AM
CIK: 0001581720
Company Name: Loxo Oncology, Inc.
File Number: 333-214392
LOXO ONCOLOGY, INC. (NASDAQ:LOXO)
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