UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 10-K
(Mark One)
☒
ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF
1934
For
the fiscal year ended December 31, 2023
OR
☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For
the transition period from to
Commission File Number: 001-40877
CERO THERAPEUTICS HOLDINGS, INC.
(Exact name of registrant as specified in its charter)
Delaware | | 81-4182129 |
(State or other jurisdiction of
incorporation or organization) | | (I.R.S. Employer
Identification No.) |
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201 Haskins Way, Suite 230 | | |
South San Francisco, CA | | 94080 |
(Address of principal executive offices) | | (Zip Code) |
(215) 731-9450
(Registrant’s telephone number, including area code)
N/A
(Former name, former address and former fiscal year,
if changed since last report)
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Securities registered pursuant to Section 12(b) of the Act: |
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Title of each class | | Trading Symbol(s) | | Name of each exchange on which registered |
Common Stock,
par value $0.0001 per share | | CERO | | Nasdaq Global Market |
Warrants to purchase one share of Common Stock | | CEROW | | Nasdaq Capital Market |
Securities registered pursuant to Section 12(g)
of the Act: None
Indicate by check mark if the Registrant is a
well-known seasoned issuer, as defined in Rule 405 of the Securities Act. YES ☐
NO ☒
Indicate by check mark if the Registrant is not
required to file reports pursuant to Section 13 or 15(d) of the Act. YES ☐
NO ☒
Indicate by check mark whether the registrant (1) has filed all
reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months
(or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements
for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically
every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during
the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒
No ☐
Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging
growth company” in Rule 12b-2 of the Exchange Act.
| |
Large accelerated filer ☐ | Accelerated filer ☐ |
Non-accelerated filer ☒ | Smaller reporting company ☒ |
| Emerging growth company ☒ |
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant has filed a report on
and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section
404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐
If securities are registered pursuant to Section 12(b) of the Act,
indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to
previously issued financial statements. ☐
Indicate by check mark whether any of those error corrections are restatements
that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during
the relevant recovery period pursuant to §240.10D-1(b). ☐
Indicate by check mark whether the registrant is a shell company (as
defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
As of June 30, 2023, the last business day
of the registrant’s most recently completed second fiscal quarter, the aggregate market value of the registrant’s voting securities
held by non-affiliates was approximately $2,688,948 based on the number of shares held by non-affiliates and the last reported sales price
of the registrant’s Class A common stock as of that date.
As of April 1, 2024, the registrant had 14,723,565 shares of common
stock, par value $0.0001 per share, outstanding.
Table of Contents
CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Annual Report on
Form 10-K (this “Annual Report”) contains forward-looking statements within
the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the
Securities Exchange Act of 1934, as amended (the “Exchange Act”). All statements other than statements of
historical facts contained in this Annual Report, including statements regarding our future results of operations and financial
position, business strategy, drug candidates, planned preclinical studies and clinical trials, results of preclinical studies,
clinical trials, research and development (“R&D”) costs, regulatory approvals, timing and likelihood of success, as
well as plans and objectives of management for future operations, are forward-looking statements. These statements involve known and
unknown risks, uncertainties and other important factors that are in some cases beyond our control and may cause our actual results,
performance or achievements to be materially different from any future results, performance or achievements expressed or implied by
the forward-looking statements.
In some cases, you can identify
forward-looking statements by terms such as “may,” “will,” “should,” “would,” “expect,”
“plan,” “anticipate,” “could,” “intend,” “target,” “project,”
“believe,” “estimate,” “predict,” “potential,” or “continue” or the negative
of these terms or other similar expressions. Forward-looking statements contained in this Annual Report include, but are not limited to,
statements about:
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our financial performance; |
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our ability to obtain additional cash and
the sufficiency of our existing cash, cash equivalents and marketable securities to fund our future operating expenses and capital
expenditure requirements, including the development and, if approved, commercialization of our product candidates; |
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our ability to realize the benefits expected
from the business combination (the “Business Combination”) pursuant to the Business Combination Agreement, dated as of
June 4, 2023, as amended from time to time (as amended, the “Business Combination Agreement”), by and among CERo Therapeutics,
Inc. (“Legacy CERo”), Phoenix Biotech Acquisition Corp. (“PBAX”) and PBCE Merger Sub, Inc. (“Merger
Sub”); |
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successfully defend litigation that may
be instituted against us in connection with the Business Combination; |
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the accuracy of our estimates regarding
expenses, future revenue, capital requirements, and needs for additional financing; |
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the scope, progress, results and costs of
developing CER-1236 or any other product candidates we may develop, and conducting preclinical studies and clinical trials; |
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the timing and costs involved in obtaining
and maintaining regulatory approval of CER-1236 or any other product candidates we may develop, and the timing or likelihood of regulatory
filings and approvals, including our expectation to seek special designations or accelerated approvals for our drug candidates for
various indications; |
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current and future agreements with third
parties in connection with the development and commercialization of CER-1236 or any other future product candidate; |
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our ability to advance product candidates
into and successfully complete clinical trials; |
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the ability of our clinical trials to demonstrate
the safety and efficacy of CER-1236 and any other product candidates we may develop, and other positive results; |
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the size and growth potential of the markets
for our product candidates, and its ability to serve those markets; |
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the rate and degree of market acceptance
of our product candidates; |
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our plans relating to commercializing CER-1236
and any other product candidates we may develop, if approved, including the geographic areas of focus and our ability to grow a sales
team; |
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the success of competing drugs, therapies
or other products that are or may become available; |
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developments relating to our competitors
and our industry, including competing product candidates and therapies; |
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our plans relating to the further development
and manufacturing of CER-1236 and any other product candidates we may develop, including additional indications that we may pursue
for CER-1236 or other product candidates; |
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existing regulations and regulatory developments
in the United States and other jurisdictions; |
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our potential and ability to successfully
manufacture and supply CER-1236 and any other product candidates we may develop for clinical trials and for commercial use, if approved; |
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the rate and degree of market acceptance
of CER-1236 and any other product candidates we may develop, as well as the pricing and reimbursement of CER-1236 and any other product
candidates we may develop, if approved; |
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our expectations regarding our ability to
obtain, maintain, protect and enforce intellectual property protection for CER-1236 and for any other product candidate; |
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our ability to operate its business without
infringing, misappropriating or otherwise violating the intellectual property rights of third parties; |
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our ability to realize the anticipated benefits
of any strategic transactions; |
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our ability to attract and retain the continued
service of our key personnel and to identify, hire, and then retain additional qualified personnel and our ability to attract additional
collaborators with development, regulatory and commercialization expertise; |
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our ability to maintain proper and effective
internal controls; |
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the ability to obtain or maintain the listing
of our common stock, par value $0.0001 per share (“Common Stock”), and our public warrants (“Public Warrants”)
on the Nasdaq Stock Market LLC (“Nasdaq”) following the Business Combination; |
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the impact of macroeconomic conditions and
geopolitical turmoil on our business and operations; |
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our expectations regarding the period during
which we will qualify as an emerging growth company under the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”)
and as a smaller reporting company under the federal securities laws; and |
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our anticipated use of our existing cash,
cash equivalents and marketable securities. |
We have based these forward-looking
statements largely on our current expectations and projections about our business, the industry in which we operate and financial trends
that we believe may affect our business, financial condition, results of operations and prospects, and these forward-looking statements
are not guarantees of future performance or development. These forward-looking statements speak only as of the date of this Annual Report
and are subject to a number of risks, uncertainties and assumptions described in “Risk Factors” and elsewhere in this
Annual Report. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted
or quantified, you should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected
in our forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the
forward-looking statements. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements
contained herein until after we distribute this Annual Report, whether as a result of any new information, future events or otherwise.
In addition, statements that
“we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based upon
information available to us as of the date of this Annual Report, and while we believe such information forms a reasonable basis for such
statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted an
exhaustive inquiry into, or review of, all potentially available relevant information. These statements are inherently uncertain, and
you are cautioned not to unduly rely upon these statements.
This Annual Report includes
trademarks, tradenames and service marks that are the property of other organizations. Solely for convenience, trademarks and tradenames
referred to in this Annual Report appear without the ® and ™ symbols, but those references are not intended to indicate, in
any way, that we will not assert, to the fullest extent under applicable law, our rights, or that the applicable owner will not assert
its rights, to these trademarks and tradenames.
Unless the context otherwise
requires, all references herein to “we,” “us,” or “our” refer to the business and operations of PBAX
and its subsidiaries prior to consummation of the Business Combination and to CERo Therapeutics Holdings, Inc. (“CERo”) and
its subsidiaries following the consummation of the Business Combination.
RISK FACTORS SUMMARY
Our
business is subject to numerous risks and uncertainties that you should consider before investing in our securities. Some of the principal
risk factors are summarized below:
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We have incurred significant losses in every
year since our inception. We expect to continue to incur losses over the next several years and may never achieve or maintain profitability. |
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Our independent registered public accountants
have expressed substantial doubt as to our ability to continue as a going concern. |
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Our business is highly dependent on the
success of our lead product candidate. If we are unable to advance clinical development, obtain approval of and successfully commercialize
our lead product candidate for the treatment of patients in approved indications, our business would be significantly harmed. |
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Our engineered Chimeric Engulfment Receptor
T (“CER-T”) cells represent a novel approach to cancer treatment that creates significant challenges for us. |
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preclinical programs may experience delays or may never advance to clinical trials, which
would adversely affect our ability to obtain regulatory approvals or to commercialize these
programs on a timely basis or at all, which would have an adverse effect on our business. |
| ● | Success
in preclinical studies or clinical trials may not be indicative of results in future clinical
trials. |
| ● | Manufacturing
genetically engineered products is complex and we, or our third-party manufacturers, may
encounter difficulties in production. If we or any of our third-party manufacturers encounter
such difficulties, our ability to provide supply of our product candidates for clinical trials
or our products for patients, if approved, could be delayed or prevented. |
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we are unable to advance clinical development, obtain approval of and successfully commercialize
our lead product candidate for the treatment of patients in approved indications, our business
would be significantly harmed. |
| ● | Genetic
engineering of T cells to create CER-T cells is a relatively new technology, and if we are
unable to use this technology in our intended product candidates, our revenue opportunities
will be materially limited. |
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may not be successful in our efforts to identify or discover additional product candidates. |
| ● | Data
from our preclinical trials is limited and may change as patient data becomes available or
may not be validated in any future or advanced clinical trial. |
| ● | Clinical
trials are difficult to design and implement, involve uncertain outcomes and may not be successful. |
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will depend on enrollment of patients in our clinical trials for our product candidates.
If we encounter difficulties enrolling patients in our clinical trials, our clinical development
activities could be delayed or otherwise adversely affected. |
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face competition from companies that have developed or may develop product candidates for
the treatment of the diseases that we may target, including companies developing novel therapies
and platform technologies. If these companies develop platform technologies or product candidates
more rapidly than we do, if their platform technologies or product candidates are more effective
or have fewer side effects, our ability to develop and successfully commercialize product
candidates may be adversely affected. |
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operate in a rapidly changing industry and face significant competition, which may result
in others discovering, developing or commercializing products before or more successfully
than we do. |
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are highly dependent on our key personnel, including individuals with expertise in cell therapy
development and manufacturing, and if we are not successful in attracting and retaining highly
qualified personnel, we may not be able to successfully implement our business strategy. |
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will need substantial additional financing to develop our products and implement our operating
plans, which financing we may be unable to obtain, or unable to obtain on acceptable terms.
If we fail to obtain additional financing, we may be unable to complete the development and
commercialization of our product candidates. |
| ● | If
our security measures, or those of our contract research organizations (“CROs”),
contract development and manufacturing organizations (“CDMOs”), collaborators,
contractors, consultants or other third parties upon whom we rely, are compromised or the
security, confidentiality, integrity or availability of our information technology, software,
services, networks, communications or data is compromised, limited or fails, we could experience
a material adverse impact. |
| ● | Our
product candidates may cause undesirable side effects, safety concerns, efficacy problems
or have other properties that have halted and could in the future halt their clinical development,
prevent their regulatory approval, limit their commercial potential or result in significant
negative consequences. |
| ● | We
will rely on third parties to conduct our clinical trials. If these third parties do not
properly and successfully carry out their contractual duties or meet expected deadlines,
we may not be able to obtain regulatory approval of or commercialize our product candidates. |
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rely on third parties to manufacture and store our clinical product supplies, and we may
have to rely on third parties to produce and process our product candidates, if approved.
There can be no assurance that we will be able to establish or maintain relationships with
such third parties. We may in the future establish our own manufacturing facility and infrastructure
in addition to or in lieu of relying on third parties for the manufacture of our product
candidates, which would be costly, time-consuming and which may not be successful. |
| ● | We
maintain single supply relationships for certain key components, and our business and operating
results could be harmed if supply is restricted or ends or the price of raw materials used
in our suppliers’ manufacturing process increases. |
| ● | Our
product candidates rely on the availability of specialty raw materials. |
| ● | Clinical
development and the regulatory approval process involve a lengthy and expensive process with
an uncertain outcome and results of earlier studies and preclinical data, and trials may
not be predictive of future clinical trial results. If our preclinical studies and clinical
trials are not sufficient to support regulatory approval of any of our product candidates,
we may incur additional costs or experience delays in completing, or ultimately be unable
to complete, the development of such product candidate. |
| ● | Regulatory
requirements in the United States and abroad governing cell therapy products have changed
frequently and may continue to change in the future, which could negatively impact our ability
to complete clinical trials and commercialize our product candidates in a timely manner,
if at all. |
| ● | We
are subject to stringent and changing privacy laws, regulations and standards as well as
policies, contracts and other obligations related to data privacy and security. |
| ● | Our
intellectual property rights are valuable, and any inability to protect them could reduce
the value of our products, services and brand. |
| ● | An
active trading market for our Common Stock may not be available on a consistent basis to
provide stockholders with adequate liquidity. The price of our Common Stock may be extremely
volatile, and stockholders could lose all or part of their investment. |
| ● | Unstable
market and economic conditions may have serious adverse consequences on our business, financial
condition and stock price. |
| ● | We
will incur significant increased costs as a result of operating as a public company, and
our management will be required to devote substantial time to new compliance initiatives
and corporate governance practices. |
| ● | Our
failure to meet the continued listing requirements of Nasdaq could result in a delisting
of our securities. |
| ● | Because
we became a public reporting company by means other than a traditional underwritten initial
public offering, our stockholders will face additional risks and uncertainties. |
| ● | Since
the completion of our initial public offering (“IPO”), there has been a precipitous
drop in the market values of companies formed through mergers involving special purpose acquisition
companies. Accordingly, securities of companies such as ours may be more volatile than other
securities and may involve special risks. |
| ● | Securities
of companies formed through mergers with special purpose acquisition companies such as ours
may experience a material decline in price relative to the share price of the special purpose
acquisition companies prior to the merger. |
| ● | Our
Warrants will become exercisable for our Common Stock, which would increase the number of
shares eligible for future resale in the public market and would result in dilution to our
stockholders. |
PART
I
Item 1. Business.
Overview
We
are an innovative immunotherapy company advancing the development of next-generation engineered T cell therapeutics for the treatment
of cancer. Our proprietary approach to T cell engineering, which enables us to integrate certain desirable characteristics of both innate
and adaptive immunity into a single therapeutic construct, is designed to engage the body’s full immune repertoire to achieve optimized
cancer therapy. Our novel cellular immunotherapy platform is designed to redirect patient-derived T cells to eliminate tumors by building
in engulfment pathways that employ phagocytic mechanisms to destroy cancer cells, creating what we refer to as CER-T cells. We believe
the differentiated activity of CER-T cells will afford them greater therapeutic application than currently approved chimeric antigen
receptor T (“CAR-T”) cell therapies, for use spanning both hematological malignancies and solid tumors. We are nearing completion
of extensive preclinical testing and studies which are needed to obtain regulatory clearance to initiate human clinical trials with CER-1236,
and have engaged in a pre-IND meeting with the Federal Drug Administration (the “FDA”). We anticipate filing an investigational new drug (“IND”) application
and, if allowed to proceed, initiating clinical trials for our lead drug candidate, CER-1236, in 2024. However, manufacturing delays
or other delays with IND-enabling studies, among other factors, may impact the timing and approval of such trials.
The
ability to enhance the activity of T cells against human cancers through genetic engineering has been among the most significant advances
in cancer therapy in the last decade. One of the more promising therapeutic uses of T cells to emerge has been CAR-T cell technology.
Yet as remarkable a development as CAR-T cell therapy has been, its use has been largely limited to the treatment of certain hematological
cancers due to CAR-T cells’ limited ability to proliferate, traffic, and circulate in solid tumors. Curative cell therapies for
solid tumors currently do not exist, and the significance of this limitation is underscored by the prevalence of solid tumor malignancies.
The American Cancer Society estimates that solid tumor cancers accounted for more than 1.7 million of the 1.9 million people
newly diagnosed with cancer in 2022. Even in hematological malignancies with approved CAR-T cell therapies, cure rates do not exceed
60%. Nevertheless, despite such limitations, sales of CAR-T cell therapies are anticipated to grow rapidly over the next several years
and are expected to exceed $10 billion globally by 2030.
We
believe that the preferential attributes engineered into our CER-T cell therapy enables us to overcome many of the limitations which
hinder the wider application of CAR-T technology. Our CER-T cells employ a novel targeting mechanism that enables the use of phagocytic
pathways. Specifically, they target phosphatidylserine (“PS”), a critical component of the cell’s plasma membrane that
has a key role in cell cycle regulation. Exposure of PS on the outer surface of the plasma membrane acts as an “eat-me” signal
and marks abnormal, stressed and dying or dead cells for phagocytosis. The pro-phagocytic activities of CER-T cells are designed to integrate
innate immune effector functions into cytotoxic killer T cells, creating within a single T cell the ability to directly mediate cytotoxic
effects and indirectly prime other immune cells. As externally oriented PS is ubiquitously expressed by numerous cancer cell types, we
believe a single CER-T construct may have broad clinical utility in treating an array of cancers. Moreover, in preclinical studies, we
have observed CER-T cells to exhibit superior cross-presentation abilities compared to conventional T cells, potentially triggering a
broad complement of immune effector cells against tumors. In consequence, we envision CER-T therapeutics as potentially having differentiated
therapeutic utility with application across a wide array of cancer types.
We
have patterned the design of our CER-T constructs based upon many of the components found in existing conventional CAR-T cell therapies,
which we believe could shorten development timelines and enhance commercial application. The processes and protocols used to genetically
modify a patient’s T cells to produce CAR-T cells are already well recognized, as is the use of lentivirus in the manufacture of
these therapies. Accordingly, we have developed CER-T cell manufacturing processes that closely resemble those used to produce existing
engineered CAR-T cells. We also expect to benefit from the well-defined and recognized regulatory guidelines established by both U.S. and
European regulatory authorities related to CAR-T therapy and its use. In contrast to these attributes, we believe that other emerging
CAR-based drug candidates which involve immune effector cells other than T cells, such as CAR-NK and CAR-M therapies, that are in the
earlier stages of clinical development are unlikely to enjoy similar benefits.
In
preclinical studies, we have observed CER-1236 to display attractive functional attributes, among which are:
| ● | target-dependent
activation, anti-tumor cytokine production and high proliferative capacity; |
| ● | phagocytosis
of tumor cells; |
| ● | distinct
transcriptome, cytokine and chemokine signatures that substantiate the complementary activity of both the innate and adaptive immune
response; |
| ● | enhanced
antigen acquisition, processing and presentation; |
| ● | no
evidence of T cell exhaustion despite repeated challenges; |
| ● | no
observed off-target or off-tumor toxicities; |
| ● | expression
and maintenance of diverse T cell populations, including naïve and memory cells, likely indicative of response persistence and durability;
and |
| ● | well
defined and scalable manufacturing protocols. |
Based
on the preclinical data regarding the use of CER-1236 T cells to combat hematologic malignancies, we currently intend to file an IND
application to begin clinical trials in 2024. We anticipate that our initial targets will be relapsed, remitting acute myeloid leukemia
(“AML”) patients as well as aggressive, difficult-to-treat B cell malignancies, including aggressive mantle cell lymphoma
(“MCL”) and refractory chronic lymphocytic leukemia (“CLL”). AML is a heterogenous and aggressive hematopoietic
malignancy characterized by the rapid buildup of immature myeloid cells in the bone marrow and blood. This process results in the inhibition
of normal hematopoiesis, manifesting as neutropenia, anemia, thrombocytopenia, and the clinical features of bone marrow failure. AML
accounts for 90% of all acute leukemias in adults, with an estimated 20,240 new cases and 11,400 deaths expected in the United States
in 2023. The disease often presents with signs and symptoms related to infiltration of leukemic blasts into the bone marrow resulting
in infections and disruption of normal hematopiesis and is associated with a variety of laboratory derangements in addition to abnormal
blood counts. The current treatment has remained largely unchanged over several decades with combination chemotherapy with cytarabine
for 7 days and an anthracycline for 3 days (“7+3”). Newer, targeted approaches that include multi-kinase domain inhibitors
and antibody-drug conjugates are now available during induction chemotherapy for certain patients. For patients that are sufficiently
healthy and at unfavorable risk, allogeneic Hematopoietic Stem Cell Transplants (“HSCTs”) are commonly performed. Despite
these interventions, there is significant unmet medical need for novel therapies, including cell therapeutic approaches. In the difficult-to-treat
B-cell malignancies, durable responses with CAR-T cell therapy are often evasive and the high frequency of acute multi-organ complications
often limits its use, particularly among chronically ill or elderly patients. Existing FDA-approved CD19-targeted CAR-T cell therapies produce an overall response rate of between 50% and 80%. Our Phase 1 clinical trial
of around 25 patients, is intended to evaluate the safety, potential therapeutic utility and applicable dose of CER-1236. Following a
trial in these hematological malignancies, we intend to expand the clinical development of CER-1236 to include solid tumors such as non-small
cell lung cancer (“NSCLC”) and ovarian cancer. We believe that CER-1236 has the potential to be a therapy for the unmet needs
of targeted indications, if approved, and differentiated by its safety, tolerability, efficacy and clinical benefit over current therapeutic
alternatives, which have been observed in preclinical studies. None of the abovementioned statements regarding any of our products in
development are intended to be a prediction or conclusion of efficacy. No clinical trials on our product candidates have commenced so
no conclusions relating to such attributes can be made.
Our Strategy
Our
intent is to become a leading biopharmaceutical company focused on the capital-efficient advancement of innovative anti-cancer product
candidates targeting the unmet medical need associated with aggressive and difficult-to-treat hematological malignancies and solid tumors.
To accomplish this objective, the key elements of our strategy include:
| ● | Advance
the clinical development of CER-1236 for the treatment of AML patients and difficult-to-treat B cell malignancies. Based on preclinical
data generated to date related to the use of CER-1236 to treat hematological cancers, we intend to initially target relapsed and refractory
AML patients as well as MCL and refractory or relapsed CLL for clinical development. These are aggressive cancers with limited treatment
options. Moreover, these cancers represent a significant unmet medical need, as patients diagnosed with AML, MCL or refractory or relapsed
CLL are often ineligible for CAR-T cell therapy. Approximately 20,000 cases of AML, 4,800 cases of MCL and 19,000 cases of CLL are diagnosed
annually in the U.S. |
| ● | Leverage
past and current CAR-T product approvals to shorten the regulatory and manufacturing pathway for CER-1236. We have designed our CER-T
cells to share similar construction to currently approved CAR-T cell therapies. The processes and protocols used to produce autologous
CAR-T cells are well recognized, and we expect to benefit from the well-defined regulatory guidelines established by both U.S. and
European regulatory authorities related to CAR-T cell therapy manufacture. Accordingly, we have configured CER-T cell manufacturing processes
to share similarities with those employed in the production of CAR-T cells. |
| ● | Expand
CER-1236 development activities to target solid tumors. If supported by the clinical data of CER-1236 for the treatment of AML and/or
B cell malignancies, we subsequently intend to expand the clinical development of CER-1236 to include solid tumors. To this end, we plan
on evaluating the potential therapeutic utility of CER-1236 to treat NSCLC and ovarian cancer, indications for which efficacious treatments
have proven elusive. We believe CER-1236’s differentiated mechanism of action enables the enhanced activity of a broader contingent
of immune effector cells, which may allow CER-1236 to achieve success treating cancers for which currently approved CAR-T cell therapies
have demonstrated little clinical benefit. |
| ● | Seek
strategic partnerships for select indications. CER-1236 is designed to have broad application in the treatment of both hematological
diseases and solid tumor indications. As such, we believe this single therapeutic candidate may offer opportunity in multiple treatment
protocols. We intend to pursue preclinical and clinical development opportunities for certain of these cancers in a capital-efficient
manner, including selectively pursuing strategic partnerships with leading biopharmaceutical companies with clinical development expertise
to maximize the value of our pipeline. As we seek to commercialize any approved products, we plan to retain worldwide rights for certain
development initiatives, while considering partnership opportunities for others. |
The Immune
System and its Function
The
immune system is a host defense system comprising multiple structures and processes within an organism that protects against disease.
As with other mammalian species, the human immune system is segregated into two separate yet interconnected components, the innate immune
system and the adaptive immune system. The innate immune system is responsible for an immediate, non-specific response to infected or
diseased cells. Triggering its activation are pathogen-associated and damage-associated molecular patterns recognized by preconfigured
pattern recognition receptors which reside on the surface of various types of leukocytes, or white blood cells, that make up the innate
immune system, including macrophages, dendritic cells, eosinophils and natural killer (“NK”) cells. In addition to its direct
participation in eliminating damaged or diseased cells, certain components of the innate immune system function significantly as antigen-presenting
cells (“APCs”) promoting the activity of the adaptive immune system.
The
adaptive immune system is composed of special types of leukoctyes known as T and B lymphocytes, also known as T and B cells, respectively.
T cells participate primarily in the cell-mediated immune response while B cells are involved in the humoral immune response. T
cells are an essential component of the adaptive immune system, targeting specific antigens and either destroying targeted cells directly
or participating in their destruction by activating other immune cells. T cells use T cell specific receptors to recognize antigens presented
via major histocompatibility complex (“MHC”) molecules on APCs. Through this mechanism, T cells have the ability to target
tumor-transformed or virus infected cells, as well as help coordinate the activity of other immune cells.
T
cells are differentiated by the expression of protein markers on their surface. The two most prominent types of T cells are those
that express CD8 molecules and are known as CD8 T cells, and those that express CD4 molecules and are known as CD4 T cells. CD8 T cells,
also referred to as cytotoxic lymphocytes (“CTLs”), eliminate cells which they encounter that are recognized as being infected
with viruses or other pathogens or are otherwise damaged or dysfunctional through a process referred to as cell lysis, which involves
the release by these killer T cells of perforins and granzymes to compromise the integrity of the target cell’s membrane. Endogenous
pathogens are broken down by mechanisms present in virtually all cells into smaller fragments and presented to CD8 T cells in combination
with an MHC class I molecule. CD4 T cells, also referred to as T helper cells, have limited cytotoxic activity and typically do
not kill infected or dysfunctional cells or eliminate pathogens directly. Instead, they participate in the immune response by providing
signals which activate and orchestrate other types of immune cells to perform these tasks. Professional APCs, such as dendritic cells
and macrophages, process exogenous pathogens and then present small fragments of the degraded pathogen to CD4 T cells in combination
with an MHC class II molecule, through a phenomenon known as cross-presentation, antigens of exogenous origin are coupled with an
MHC Class I molecule to amplify CD8 T cell activity. Antigen cross presentation is of particular importance in the immune system’s
response to cancer.
Genetically
Engineered T Cells
The
ability to enhance the activity of T cells against human cancers through genetic engineering has been among the most significant advances
in cancer therapy in the last decade. Advances in understanding T cells and their role in immunology, and an appreciation of their potential
use to treat cancer, has increased interest in the clinical application of T cells in recent years, with the field of adoptive immunotherapy
attaining increased prominence as a means of enhancing immune control over tumors. Modern molecular biological techniques allow scientists
to introduce genes into human T cells that enhance T cell activity, expand their numbers and infuse them back into the patient from whom
they were originally harvested. We have developed a novel approach to T cell engineering which has enabled us to integrate certain desirable
characteristics of both the innate immune system and the adaptive immune system into a single therapeutic construct intended to optimize
cancer therapy. This novel cellular immunotherapy platform is designed to redirect T cells to eliminate tumors by building in engulfment
pathways that employ phagocytic programs, creating our CER-T cell therapy.
Phagocytosis
is a vital cellular process by which a phagocytic cell engulfs and internalizes a target for elimination and is a major mechanism for
the removal of pathogens and unwanted cells to maintain tissue homeostasis. The human body removes billions of cells daily through phagocytic
processes. Phagocytic removal employs specific cell clearance programs and machinery to eliminate target cells. The process is a crucial
part of the innate immune system and is distinct from the adaptive immune response which involves the generation of cytotoxic T cells
to elicit antigen-specific, cytolytic target elimination. To optimize anti-tumor function, we developed CER-T cell therapy to collaboratively
mediate both cytotoxic and phagocytic mechanisms. By leveraging the strength of both immune responses, engulfment has the potential for
more silent and nontoxic cell removal compared to current CAR-T cell therapies. By leveraging both immune responses, we believe CER-T
cell therapy has the potential to eliminate cancer cells more effectively and with fewer side effects than traditional CAR-T cell therapies.
The
recognition of phagocytosis as a therapeutic modality to directly clear cancer cells and initiate anti-tumor T cell immune responses
has fueled interest in effectively engaging phagocytes for use in cancer therapy. Macrophage cell engineering and macrophage-targeting
approaches that enhance cytotoxic, phagocytic and cytokine-mediated anti-tumor function are in development. Early clinical trial data
from therapeutic candidates targeting myeloid inhibitor function has demonstrated the potential to elicit clinical responses. However,
the diverse pro-tumor functions of myelo-monocytic cells may offset these efforts by supporting cancer cell survival, proliferation and
the release of factors that may impede anti-tumor immune responses. Limited in vivo proliferation and manufacturing challenges have also
been hurdles in the development of mononuclear phagocyte-based cellular therapy.
Experimental
evidence demonstrates the ability of CER-T cells to engulf targeted cells, employ cytolytic and non-cytolytic killing mechanisms, and
exhibit pro-inflammatory and antigen processing capabilities that augment the current capabilities of T cell immunotherapy. To that end,
we believe CER-T cell therapy, if approved, may become a component of standard of care treatment regimens, used in combination with both
small molecule therapeutics and biologics including monoclonal antibodies, and CAR-T and high affinity T cell receptor (“TCR”)
T cell therapies to direct robust tumor elimination.
The Increasing
Prominence of CAR-T Technology
Immunotherapy
is a treatment that harnesses the components and mechanics of the immune system to address diseases and disorders. Cellular immunotherapy
is a form of immunotherapy that focuses on modulating or enhancing the activity of different immune cells. One of the more prominent
and promising therapeutic uses of T-cells to emerge has been CAR-T cell technology.
CAR-T
therapy recognizes specific antigens that are present on the surface of tumor cells and destroys them. The concept of CAR-T builds upon
the normal biology of CTLs, whereby naturally occurring receptors serve to activate these cells when a foreign pathogen or cancerous
cell is detected. Conventional CAR-T cell therapy involves the genetic manipulation of a patient’s T cells to enable the expression
by those modified cells of a receptor designed to bind to a specific surface antigen. After the removal of the T cells from the patient’s
blood, a viral vector containing the genetic instructions for the CAR is employed to insert those genes into the genome of the T cell
through a process known as transduction. Aggregated in a single viral vector are the genes encoding for each component of the CAR. Typical
of the prevailing generation of CAR architecture is the inclusion of these components:
| ● | Antigen
recognition domain. At one end of the CAR is a binding domain that is specific to a targeted antigen. This domain is exposed to the
outside of the engineered lymphocyte, where it can recognize the target antigen or antigens. The extracellular target binding domain
of CAR-T therapies currently approved by the FDA typically use a single-chain variable fragment (“scFv”), consisting of the
heavy-chain and light-chain variable regions of an antibody. |
| ● | Extracellular
hinge domain. The hinge domain is a small structural component which extends from the outer cell membrane to the antigen recognition
domain and provides conformational flexibility to facilitate optimal binding of the antigen recognition domain to the targeted antigen
on the surface of the cancer cell. |
| ● | Transmembrane
domain. This middle portion of the CAR links the antigen recognition domain to the activating elements inside the cell. The transmembrane
domain anchors the CAR in the lymphocyte’s membrane, bridging the extracellular hinge and antigen recognition domains with the
intracellular signaling domain and provides critical stability to the CAR. In addition, the transmembrane domain may also interact
with other transmembrane proteins that enhance CAR function. |
| ● | Intracellular
signaling domain. The other end of the CAR, inside the T cell, is connected to two or more contiguous domains responsible for activating
the lymphocyte when the CAR binds to its target antigen. The first, found in almost all CAR constructs, is called CD3-ξ. The CD3-ξ
domain delivers an essential primary signal within the T cell and is the natural basis for activation of these lymphocytes. The current
generation of CAR-T configurations generally employ one or more costimulatory domains, such as CD28, to provide enhanced activation signals
and augment lymphocyte activity. Together, these signals result in the proliferation of the CAR-enabled T cells and selective cellular
destruction. In addition, activated CAR-T cells stimulate the local secretion of cytokines and other molecules that can recruit and activate
additional immune cells to increase target elimination. |
The
assembly of these core CAR components is depicted in the schematic presented below to which certain non-coding regulatory sequences may
be used to augment viral gene expression.
Delivery
of conventional CAR-T cell therapies involves a single viral vector.
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_001.jpg)
Conventional
CAR-T cell therapies often utilize a lentiviral vector for the delivery of CAR specific genes. Lentiviral particles offer a well-characterized
transduction mechanism and are recognized as efficient and convenient vehicles for gene transfer as they demonstrate broad tropism, or
activity, in a wide array of cell types, and can be used to target quiescent, or non-dividing, cells. In addition, they do not integrate
close to the promoter regions of genes with the frequency of other gene delivery alternatives and lack the immunogenicity of DNA-based
vectors, characteristics which provide for enhanced safety. The use of a lentiviral vector to facilitate ex vivo clinical gene transfer
has been demonstrated to be safe in humans for two decades with no genotoxicity observed in hundreds of patients following gene transfer
into T cells or hematopoietic progenitor cells.
Currently,
six CAR-T cell therapies have been approved by the FDA for the treatment of certain types of hematological cancers. The first two, approved
in 2017, are axicabtagene ciloleucel, sold by Gilead Sciences under the brand name Yescarta, and tisagenlecleucel, sold by Novartis under
the brand name Kymriah. A third CAR-T cell therapy, brexucabtagene autoleucel, which is comparable to Yescarta and sold by Gilead under
the tradename Tecartus, was approved in 2020. Lisocabtagene matraleucel, sold by Bristol Myers Squibb under the brand name Breyanzi,
received FDA approval in February 2021 with Bristol Myers Squibb also receiving approval for idecabtagene vicleucel, sold under
the tradename Abecma, in March of that year. Most recently, Janssen Biotech received FDA approval for ciltacabtagene autoleucel, brand
name Carvykti, to treat adult patients with relapsed or refractory multiple myeloma and which targets the BMCA protein expressed on cancer
cells rather than CD19, the target of the other approved CAR-T cell therapies. Each of these therapies is an autologous therapy and is
made from T cells first collected from the patient, which are then genetically modified and administered back to the same patient. Sales
of CAR-T cell therapies are anticipated to grow rapidly over the next several years and are expected to exceed $10 billion
by 2030. CAR-constructs incorporating alternate immune effector cell types, including NK cells and macrophages, are in earlier stages
of clinical development and have only recently entered clinical trials. To date, no CAR-based therapies that employ NK cells or macrophages
have received FDA approval. There are at present no FDA approved CAR T cell products for AML.
The Limitations
of Current CAR-T Technology
Much
of the excitement of cellular therapy surrounds the curative potential of adoptive transfer of genetically engineered T cells. Adoptively
transferred T cells proliferate upon their engagement with target antigens and represent a form of therapy that can be appropriately
characterized as living and expanding. Efficient targeted killing and tumor elimination may be achieved in a short period of time. However,
multiple barriers limit the efficacy of conventional CAR-T cell therapy. A high rate of side effects often accompany treatment with currently
approved products, especially in those patients with high tumor burdens. In addition, partial responses occur, often associated with
immune escape of the tumor from the TCR or the display by the T cells of an exhaustion phenotype. Moreover, while engineered CAR-T cells
have shown remarkable potential in the treatment of hematological cancers, they have not demonstrated equivalent efficacy in the treatment
of solid tumors. Curative cell therapies for solid tumors currently do not exist and the importance of this limitation is underscored
by the prevalence of solid tumor malignances. The American Cancer Society estimates that solid tumor cancers accounted for more than
1.7 million of the 1.9 million people newly diagnosed with cancer in 2021. Even in hematological malignancies with approved
CAR-T cell therapies, less toxic orthogonal treatment approaches are needed as cure rates for CD19-targeted CAR-T cell therapies do not
exceed 60%.
Challenges
to the use of cellular therapy to address solid tumors often relate to difficulty in developing receptors directed towards targets expressed
in high frequency on cancer cells as well as overcoming the immunosuppressive microenvironments that contribute to ineffective immune
responses. The tumor stroma, made up of a dense fibrotic matrix, often surrounds solid tumors and acts as a physical barrier, which restricts
CAR-T cell access to the tumor. CAR-T cell activity may be further hindered by the tumor microenvironment (“TME”). In the
TME, multiple cell types which drive immunosuppression infiltrate solid tumors, including myeloid-derived suppressor cells, tumor-associated
macrophages, and regulatory T cells. The interaction of these cells and the tumor cells increases the expression of signaling molecules
that enable tumor cell proliferation while dampening the generation of co-stimulatory signals necessary for T cell expansion and persistence.
In addition, TME-associated immune dysfunction may result in a down regulation of MHC class I molecules, limiting proper antigen
presentation and T cell proliferation. Collectively, these attributes of solid tumors enable them to avoid normal immune surveillance.
Increased engagement of the endogenous host response is also an important, if not critical, component of CAR-T cell therapy clinical
success as the recruitment into the tumor of bystander lymphocytes has been observed in tumor biopsies from patients with curative CAR-T
cell therapy. Enhancing the host’s own response to tumor cells offers an important opportunity to improve current CAR T cell responses.
CAR-T
recipients may also incur serious adverse events (“SAEs”), perhaps the most prominent of which is cytokine release syndrome
(“CRS”). Believed to be related to the rapid proliferation and activation of T cells upon detection of a target antigen,
severe or life-threatening CRS was noted in a significant number of patients who participated in the registrational trials of FDA-approved
CAR-T therapies. These SAEs can result in patients who receive conventional CAR-T therapy requiring longer hospitalizations and more
intensive medical care. The frequency and severity of observed SAEs was one of the primary reasons that administration of currently approved
CAR-T therapy is restricted to a select number of treatment centers. Moreover, aside from the low-level expression of certain cancer
specific neoantigens, most tumor associated antigens are also found on normal cells which may lead to serious, if not life threatening,
“on-target, off-tumor” toxicities.
We
believe that the preferential attributes engineered into our CER-T cell therapies have the potential to represent a next-generation adoptive
cellular immunotherapy approach and enable us to overcome many of the limitations which hinder the wider application of current CAR-T
technology. The prophagocytic and immunomodulatory properties of CER-T cells are designed to overcome some of the immunosuppressive elements
in many solid tumors. In addition, their anticipated superior antigen presentation properties may enhance a patient’s ongoing immune
response against tumor antigens. In consequence, we envision CER-T therapeutics as having a differentiated mechanism for tumor clearance
that enables the potential for enhanced activity across a broad array of hematological malignancies and solid tumors.
CER-T
Cell Therapy Technology
Distinguishing
our CER-T cell therapy candidate is the integration into a single therapeutic construct of many of the anti-tumor capabilities resident
in both the innate and the adaptive immune systems. We believe the coupling of these functions better emulates normal immune system activity
which may promote enhanced T cell activation, proliferation and durability for more robust elimination of cancerous cells and reduction
in tumor burden.
We
have designed our CER-T constructs to embrace many of the components found in conventional CAR-T cell therapies. The processes and protocols
used to genetically modify a patient’s T cells to produce CAR-T cells are well recognized, as is the use of lentivirus in the manufacture
of these therapies. Accordingly, we have constructed CER-T cell manufacturing processes to be similar to those of CAR-T cells. We expect
to benefit from the well-defined regulatory guidelines established by both U.S. and European regulatory authorities related to CAR-T
cell therapy and its use.
The biological
foundations for CER-T cell therapy
PS
is a component of a cell’s plasma membrane and has a key role in cell removal. Under normal physiological conditions, PS is restricted
to the inner leaflet of the phospholipid bilayer which makes up the plasma membrane of a cell. However, cellular stresses cause the externalization
of PS to the cell surface. Exposure of PS on the outer surface acts as an “eat-me” signal and marks abnormal, stressed and
dying or dead cells for phagocytic clearance. A variety of tumors have been shown to have increased surface PS as a result of altered
plasma membrane regulation. Among hematologic tumors, loss-of-function mutations in the flippase chaperone transmembrane protein 30A
(“TMEM30A”), have been identified in approximately 5% to 11% of patients with diffuse large B cell lymphoma (“DLBCL”)
and among a cohort of newly diagnosed patients, this mutation was correlated with improved response to the standard therapeutic regimen
suggesting the host’s immune elimination of PS positive tumor cells enhances tumor clearance. We are seeking to exploit the presence
of PS expressed on the outer cell surface of both hematological malignancies and solid tumors to create our next generation anti-cancer
agents.
CER-1236:
Our Lead Development Candidate
As
externally oriented PS is present on many cancerous cells regardless of tumor type, we believe a single CER construct may demonstrate
clinical utility in treating an array of cancers. To that end, we have focused our development activities on optimizing the cancer killing
capabilities of a specific CER-T therapeutic design. These efforts have resulted in our lead clinical candidate, CER-1236. In preclinical
studies, we have observed CER-1236 to display attractive functional capabilities and product characteristics, among which are:
| ● | target-dependent
activation, anti-tumor cytokine production and high proliferative capacity; |
| ● | tumor
cell phagocytosis; |
| ● | distinct
transcriptome, cytokine and chemokine signatures that substantiate the complementary activity of both the innate and adaptive immune
response; |
| ● | enhanced
antigen acquisition, processing and presentation; |
| ● | no
evidence of T cell exhaustion despite repeated challenges; |
| ● | no
observed off-target or off-tumor toxicities; |
| ● | expression
and maintenance of diverse T cell populations, including naïve and memory cells, likely indicative of response persistence and durability;
and |
| ● | well
defined and scalable manufacturing protocols. |
We
have designed CER-1236 to align with components included in the current generation of conventional CAR-T configurations by fusing the
external domain of TIM-4, a phagocytic receptor, with intracellular signaling domains from T cells and innate immune cells. TIM-4 harbors
endogenous phagocytic capacity through its binding to the pro-phagocytic “eat-me” signal PS. CER-1236’s intracellular
signaling domains, including TLR2/TIR, CD28 and CD3ξ motifs, are designed to augment both TIM-4 mediated phagocytosis and cytotoxic
T cell function. Another similarity between conventional CAR-T therapeutic formats and our CER-T design is the delivery vehicle used
in transduction. As is found in many approved CAR-T therapies, our CER-T technology also employs a lentiviral vector to facilitate gene
delivery to patient-derived T cells. A schematic of the structural elements of CER-1236 is presented below.
Schematic
of CER-1236
Abbreviations:
TIM-4 = ectodomain of the T cell immunoglobulin mucin domain protein 4; TLR2 = toll-like receptor 2; TIR = toll/interleukin-1 receptor.
CER-1236
employs an innovative mechanism of action
CER-1236
is an autologous T cell therapy candidate designed to target PS through the external domain of the prophagocytic receptor TIM-4 protein.
This therapeutic construct was developed to combine adaptive T cell killing activity with phagocytic clearance and antigen presentation
activity to create T cells with enhanced cancer immunotherapy capabilities. The approach builds on the early success of adoptive T cell
transfer, which has demonstrated the ability of T cells to proliferate, traffic, and circulate within both primary and metastatic tumors.
By
enhancing phagocytic clearance and antigen presentation activity and integrating them into T cells, we believe CER-T cells offer the
potential for more effective elimination of cancer cells. The industry’s decades-long experience with engineered T cell use provides
a solid foundation for the development of CER-1236.
As
the target ligand of our initial CER-T cell is not an antigen restricted to only certain tumors, CER-1236 T cells may provide clinical
benefit across multiple tumor types. The functional interaction of CER-1236 T cells is depicted in the illustration presented below.
CER-1236
T cells are designed to harness the power of both the innate and adaptive immune systems
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_002.jpg)
CER-1236
expresses the external domain of the prophagocytic receptor TIM-4 which is linked to T cell and innate immune cell intracellular signaling
domains. TIM-4 is normally expressed on subsets of macrophages and dendritic cells and harbors endogenous phagocytic capacity through
its binding to and recognition of PS. The intracellular signaling domains in CER-1236 are designed to trigger T cell cytotoxic function
and enhance TIM-4 mediated phagocytosis. CD3ξ is the signaling component of the TCR and CD28 is a co-stimulatory domain needed for
optimal activation. The TLR2/TIR domain is involved in both innate and adaptive immune responses and activation of TIR further enhances
signaling through both NFξB and the mitogen-activated protein (“MAP”) kinase family, promoting T cell activity and phagocytic
uptake. Both CD28 and CD3ξ signaling domains are incorporated into approved CAR-T cell products. A third generation anti-CD19 CAR-T
cell that incorporates a TLR2/TIR is currently in clinical development.
By
virtue of the TIM-4 engulfment receptor and the intracellular signaling domains, CER-1236 combines attributes of both T cells and phagocytic
cells. In phagocytic cells, such as macrophages and dendritic cells, recognition of the TIM-4 ligand, PS, on the surface of apoptotic
cells by native TIM-4 leads internalization by utilizing integrin coreceptors to activate phagocytic signaling. TIM-4-mediated phagocytosis
depends on activation of the RAC1 GTPase which is similarly targeted by TLR signaling, especially TLR9 and TLR2. However, it has been
shown that deletion of the intracellular portion of TIM-4 is not required for phagocytosis, and therefore the extracellular domain (“ECD”)
of TIM-4 appears to function as a tether during phagocytosis to allow intracellular signaling by other transmembrane phagocytic molecules
with which it associates, such as the integrins which are expressed ubiquitously on T cells. Since CER-1236 contains only the ECD of
TIM-4, binding to PS on tumor cells recruits the cell-surface phagocytosis machinery, and simultaneously directly activates CER-1236
T cells through the intracellular CD3ξ and CD28 costimulatory domains. Phagocytosis and cytokine secretion are further enhanced by
the TLR2/TIR intracellular signaling domain.
In preclinical
studies, CER-1236 empowers T cells with phagocytic and cytotoxic potency
In
an in vitro evaluation of the phagocytic potential of CER-1236, CER-transduced T cells demonstrated robust phagocytosis of PS. CER-1236
T cells were produced by transducing donor T cells using a lentiviral vector encoding for the chimeric receptor CER-1236, yielding a
high percentage of T cells expressing the TIM-4 receptor, in similar CD4:CD8 ratios to untransduced cells. CER-1251 T cells, which express
matching intracellular signaling domains but are unable to bind to PS due to a mutation in the gene encoding for the TIM-4 binding site,
were also produced as a negative control.
PS-coated
agarose beads were prelabeled with pHrodo red, a pH-sensitive dye which displays limited fluorescence at neutral pH but generates significant
fluorescence in acidic pH. The post-phagocytic fusion of phagosomes and lysosomes leads to a drop in pH which can be detected by
pH-sensitive dyes. As is illustrated in the graphic below, CER-1236 T cells co-cultured with PS-coated beads displayed significant phagocytic
activity with up to 60% of CER-T cells acquiring a pHrodo red signal, indicative of bead capture and internalization. By contrast, untransduced
T cells and CER-1251 T cells, with a mutation in the TIM-4 binding site, demonstrated minimal pHrodo red binding.
CER-1236
displays robust, target-specific phagocytic activity
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_003.jpg)
Gene
expression patterns demonstrate the combined cytotoxic and phagocytic functions which reside in the CER-1236 T cell. RNA-sequencing enabled
the interrogation of the transcriptional profile of CER-1236 T cells after stimulation, with defined separation between the CER-1236
activated cells and the untransduced and CER-1251 control T cells. As is presented in the gene expression profile below, over 1,700 genes
were noted to be differentially expressed in CER-1236 stimulated T cells in comparison to CER-1251 stimulated T cells. Among these genes
were those related to pathways with well-known involvement in regulating phagocytosis, genes involved in nucleation of the ARP-WASP complex,
Rho family GTPases, RAC signaling and phagosome formation. Of note, the RhoG subfamily of GTPase has been previously implicated in TCR-driven
phagocytic processes. This aggregate of transcriptional signatures is indicative of the multi-modal immune response elicited by CER-1236
T cells.
Phagocytic
and cytotoxic transcriptional signatures demonstrate the plasticity of CER-1236 T cells
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_004.jpg)
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_005.jpg)
CER-1236
T cells were also observed to generate potent anti-cancer responses in cell lines derived from specific hematological malignancies and
solid tumors. Using an MCL cell line that has been modified to constitutively express externalized cell surface PS, MCL cells were co-cultured
with either CER-1236 T cells or untransduced T cells. Notably, CER-1236 T cells eliminated 87% of the MCL cells while the untransduced
cells demonstrated minimal cytotoxic ability. In addition, CER-1236 T cells secreted multiple cytokines, including IFNξ, granzyme
B and TNFξ, all indicative of robust and sustained T cell cytotoxicity. Cytokine secretion was determined to be dependent of binding
to PS, as CER-1251 T cells did not secrete cytokines despite exposure to cell surface PS. Further visual evidence of the cancer-killing
capacity of CER-1236 T cells is illustrated in the staining assays depicted in the graphs presented below. In the assays with no CER-1236
T cells, a significant proliferation of cancer cells was observed, as evidenced by the increase in red staining, while the growth of
cancer cells when exposed to CER-1236 T cells was limited. These results are presented in the graph to the left below.
CER-1236
T cells demonstrates potent cytotoxic responses to cancer cells in vitro
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_006.jpg)
Significant
cytotoxic activity of CER-1236 was also noted in an advanced NSCLC cell line which had a mutation in its epidermal growth factor receptor
(“EGFR”) gene, a cancer type accounting for between 10% and 15% of all lung adenocarcinoma cases in persons of European descent
and higher among the Asian population. As is depicted in the above, right graph, while the addition of CER-1236 alone to a NSCLC cell
line which harbors L858R double mutations, demonstrated moderate cancer cell killing activity, the addition of osimertinib, the preferred
tyrosine kinase inhibitor option for first-line treatment of EGFR-mutation positive advanced NSCLC, substantially enhanced CER-1236 T
cell killing in a tyrosine kinase inhibitor-concentration dependent manner. In contrast, HCC827 cells co-cultured with untransduced T
cells displayed minimal changes in cell number as compared to cells incubated in the absence of T cells, at all drug concentrations tested.
Conditional cytokine proliferation was also observed with CER-1236 T cell treatment, with IFNξ levels over 400-fold higher in cancer
cell cultures which used CER-1236 T cells, in contrast to co-cultures which used untransduced T cells. The addition of osimertinib to
co-cultures further increased IFNξ levels by more than two-fold, compared with CER-1236 treatment alone. Similar trends were observed
with TNFξ and Granzyme B levels and increases in osimertinib concentrations led to dose-dependent CER-1236 T cell proliferation. These
results demonstrated that CER-1236 T cell activity could be significantly enhanced by upregulating target expression through concomitant
dosing of standard of care medication.
PS,
a lipid moiety recognized by phagocytic cells as an “eat me” signal, has previously been shown to be aberrantly upregulated
on acute promyelocytic (“APL”) blasts, a subset of AML. To further interrogate phosphatidylserine across other AML subtypes,
we evaluated a panel of primary bone marrow samples and peripheral blood from AML patients. We screened a preliminary panel of primary,
treatment-naïve or on-therapy AML bone marrow and PBMC samples by flow cytometry: (n=5 adverse, n=5 intermediate, n=1 APL, n=1 familial,
n=5 N/A) (Table 1). We observed both high percent (35.5 % ± 21.6) and gMFI of cell surface PS on a range of AML bone marrow samples.
The median MFI of tertiles 1-3 was: T1 n=7, gMFI = 5033; T2 n=8, gMFI = 1873; T3 n=8, gMFI = 611. Of note, the two on-therapy samples
showed high percent and gMFI of cell surface PS, with a patient receiving 5-azacytidine showing 1.8 fold PS gMFI over median. The second
patient receiving TKI therapy showed 3.3 fold PS gMFI over median. Healthy donor samples had much lower cell surface PS, with a mean
gMFI of 582. Circulating AML leukemic blasts were also evaluated for cell surface PS and showed high concordance with BM blasts, with
high levels of cell surface PS compared to healthy donor peripheral blood mononuclear cells (“PBMCs”).
Table
1. AML patient characteristics
Patient:
Patient ID |
|
Treatment
Status: Disease Status |
|
Previous
Treatments |
|
Patient
Age At Collection |
|
Gender |
|
Race |
|
Patient:
Ethnicity |
|
%
Blast Cells |
|
Risk
Category |
|
Genetic
Abnormality |
|
Cytogenetics |
|
200001107 |
|
Newly
Diagnosed |
|
none |
|
67 |
|
Female |
|
White |
|
Non-
Hispanic/Latino |
|
91 |
|
Adverse |
|
RUNX1 |
|
N/A |
|
200015767 |
|
Newly
Diagnosed |
|
none |
|
59 |
|
Female |
|
White |
|
Non-
Hispanic/Latino |
|
35 |
|
Adverse |
|
TP53 |
|
N/A |
|
200013141 |
|
Newly
Diagnosed |
|
none |
|
69 |
|
Male |
|
White |
|
Non-
Hispanic/Latino |
|
75 |
|
Intermediate |
|
VAF
ASXL1 < 50% |
|
N/A |
|
200015300 |
|
Newly
Diagnosed |
|
none |
|
59 |
|
Male |
|
White |
|
|
|
93.03 |
|
|
|
N/A |
|
|
|
200018491 |
|
Newly
Diagnosed |
|
none |
|
62 |
|
Female |
|
White |
|
Non-
Hispanic/Latino |
|
30 |
|
Adverse |
|
TP53 |
|
N/A |
|
130802218 |
|
Newly
Diagnosed |
|
none |
|
71 |
|
Male |
|
White |
|
|
|
94.77 |
|
|
|
N/A |
|
|
|
200018493 |
|
Newly
Diagnosed |
|
none |
|
48 |
|
Male |
|
White |
|
Non-
Hispanic/Latino |
|
82 |
|
Adverse |
|
ASXL1,
FLT3-ITD |
|
N/A |
|
200015400 |
|
Newly
Diagnosed |
|
none |
|
51 |
|
Male |
|
White |
|
Non-
Hispanic/Latino |
|
80.2 |
|
Familial |
|
GATA2
Deficiency |
|
N/A |
|
130776684 |
|
Newly
Diagnosed |
|
none |
|
38 |
|
Female |
|
White |
|
|
|
89.78 |
|
|
|
N/A |
|
|
|
200055487 |
|
Newly
Diagnosed |
|
none |
|
74 |
|
Male |
|
White |
|
|
|
80.9 |
|
|
|
N/A |
|
|
|
130781611 |
|
Newly
Diagnosed |
|
none |
|
62 |
|
Female |
|
White |
|
|
|
81.67 |
|
Intermediate |
|
N/A |
|
Normal |
|
200015406 |
|
Newly
Diagnosed |
|
none |
|
43 |
|
Male |
|
White |
|
|
|
91.37 |
|
Adverse |
|
FLT-3
ITD |
|
N/A |
|
200036152 |
|
Newly
Diagnosed |
|
none |
|
85 |
|
Female |
|
White |
|
|
|
70.13 |
|
|
|
|
|
|
|
200015557 |
|
Newly
Diagnosed |
|
none |
|
69 |
|
Female |
|
White |
|
Non-
Hispanic/Latino |
|
84 |
|
Intermediate |
|
DNMT3A |
|
N/A |
|
200019235 |
|
Stable |
|
Azacitidine
8 cycles |
|
71 |
|
Female |
|
White |
|
|
|
72.63 |
|
Intermediate |
|
N/A |
|
N/A |
|
200018645 |
|
Newly
Diagnosed |
|
none |
|
41 |
|
Male |
|
White |
|
|
|
76.54 |
|
APL |
|
N/A |
|
t(15;17) |
|
200015508 |
|
Progressive |
|
Imatinib
400 mg. |
|
63 |
|
Female |
|
White |
|
Non-
Hispanic/Latino |
|
50 |
|
Intermediate |
|
VAF
< 50% |
|
N/A |
|
200019095 |
|
Newly
Diagnosed |
|
none |
|
63 |
|
Female |
|
White |
|
|
|
82.65 |
|
|
|
|
|
|
|
200013114 |
|
Newly
Diagnosed |
|
none |
|
83 |
|
Male |
|
White |
|
|
|
56.8 |
|
|
|
NRAS |
|
|
|
130800395 |
|
Newly
Diagnosed |
|
none |
|
72 |
|
Female |
|
White |
|
|
|
75.7 |
|
Adverse |
|
TET2,
ASXL1, TP53 |
|
|
|
200015280 |
|
Newly
Diagnosed |
|
none |
|
67 |
|
Female |
|
White |
|
|
|
15.3 |
|
|
|
ETV6,
BCORL, KRAS |
|
|
|
200009820 |
|
Newly
Diagnosed |
|
none |
|
31 |
|
Male |
|
White |
|
|
|
85.7 |
|
|
|
KRAS |
|
|
|
200009056 |
|
Newly
Diagnosed |
|
none |
|
21 |
|
Female |
|
White |
|
|
|
94.8 |
|
Adverse |
|
DNMT3A,
BCORL1, TP53 |
|
|
|
AML
from bone marrow or PBMC have elevated cell surface “Eat Me” signal
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_007.jpg)
CER-1236
T cells were also observed to generate potent anti-cancer responses against myeloid malignancies. AML is a heterogenous, and aggressive
hematopoietic malignancy characterized by the rapid buildup of immature myeloid cells in the bone marrow and blood. We used AML cell
lines depicted in the graph below, Kasumi-1 and MV4-11 to demonstrate cytotoxic anti-AML responses in co-culture studies with CER-1236.
Similar to in vitro cytotoxicity results observed with B cell malignancy and NSCLC cell lines we show the addition of CER-1236 alone
to AML cell lines demonstrates potent cell killing activity. Kasumi-1 harbors a p53 mutation, marking a subset of unfavorable disease
risk AML patients, while MV4-11 cells carry a FLT-3 mutation, a proliferative AML leukemia subset. Both cell lines co-cultured with untransduced
T cells displayed minimal changes in cell number as compared to cells incubated in the absence of T cells. CER-1236 T cells secreted
multiple cytokines in co-cultures with AML cell lines, including IFNξ, granzyme B and TNFξ, all indicative of robust and sustained
T cell cytotoxicity.
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_008.jpg)
CER-1236
T cells demonstrate robust in vivo elimination of MCL xenografts
The
cancer killing capacity of CER-1236 that was demonstrated in studies involving MCL cell lines was also noted in a mouse xenograft model.
Immune deficient NOD scid gamma (“NSG”) mice were xenografted with the human REC-1 cell line at Day -2 and then treated with
8 mg/kg ibrutinib or vehicle and administered CER-1236 T cells daily from Day -1 to study completion. Administration of 7.5e6 CER-1236
T cells in the presence of ibrutinib resulted in the elimination of REC-1 tumor burden in all 11 of the mice in this treatment cohort.
The administration of CER-1236 T cells in the absence of ibrutinib eliminated the tumors in all nine animals treated with CER-1236 T
cells alone. No tumor growth inhibition was observed in either the vehicle-treated or ibrutinib-treated control groups. Median survival
for mice receiving CER-1236 T cells with or without co-administration of ibrutinib was not reached during the study period. The results
of this study are presented in the charts below.
A
single infusion of CER-1236 T cells eliminates tumors and improves survival
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_009.jpg)
The
level of CER-1236 T cells in peripheral blood displayed robust expansion at Day 7, with or without the concomitant administration
of ibrutinib. Animals that received CER-1236 T cells demonstrated an expansion of over 400-fold as compared to Day 2 levels both in the
absence and presence of ibrutinib. High levels of CER-1236 T cells did not persist in the periphery and animals that received CER-1236
T cells showed a greater than 95% contraction in cell count from peak numbers by Day 14 with subsequent CER-T cell expansion likely prompted
by residual tumor cell encounters. CER-1236 T cells also maintained robust proliferative capacity despite repeated antigen challenges
with no evidence of T cell exhaustion noted. These findings are illustrated in the following charts.
A
single infusion of CER-1236 T cells generated rapid cell expansion across repeated challenges.
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_010.jpg)
CER-1236
demonstrates in vivo tumor clearance in NSCLC adenocarcinoma xenograft.
We
envisioned that the simultaneous exposure to both osimertinib and CER-1236 would lead to synergistic in vivo anti-tumor responses. HCC827
NSCLC cells were inoculated into the flanks of NSG mice. Once established, the mice were dosed with a short course of the EGFR inhibitor
osimeretinib to prime PS antigen on tumors and administered 2.5e6 CER-1236 T cells. Treatment groups that received the EGFR inhibitor
alone, after initial tumor regression, developed progressive disease. In contrast, animals infused with CER-1236 T cells demonstrated
potent anti-tumor responses in the presence of osimertinib. CER-1236 T cells expanded rapidly in the blood, with the highest expansion
observed in the osimertinib-treated cohorts. Importantly, no evidence of organ toxicity or weight loss was observed with increases in
body weight recorded in all groups over the course of the study. Analysis of the tumors post-infusion indicated extensive infiltration
of T cells compared to untransduced controls.
CER-1236
T cells infused to Osimertinib dosed animals showed higher levels of T cell expansion
![](https://www.sec.gov/Archives/edgar/data/1870404/000121390024029051/image_011.jpg)
We
believe that the preclinical models of AML, MCL, ovarian cancer and EGFR-mutation positive NSCLC demonstrate the ability of CER-1236
T cells to induce collaborative innate-adaptive anti-tumor immune responses in both in vitro and in vivo studies. Moreover, concurrent
treatment with standard-of-care therapeutics for each of these indications increases target ligand, conditionally bolstering CER-1236
T cell function to augment anti-tumor activity. Additionally, in antigen presentation assays, activated CER-1236 T cells exhibited superior
cross-presentation ability relative to conventional T cells, triggering specific TCR-T cell responses in an MHC class I and TLR-2
dependent manner, overcoming the limited antigen presentation capabilities of conventional T cells. These results indicate that CER-1236
T cells have the potential to achieve optimal tumor control by eliciting both cytotoxic effects and mediated cross-priming.
CER-1236
T cells did not elicit safety signals in preclinical studies
Importantly,
no evidence of toxicity was observed after the single administration of 7.5e6 CER-1236 T cells. No incidence of anemia, thrombocytopenia,
neutropenia or coagulation abnormalities were recorded. Complete blood count, prothrombin time, and partial thromboplastin time were
measured in blood taken at the peak of T cell expansion and after T cell contraction. Hematologic indices, including hemoglobin/hematocrit,
platelets and neutrophils remained stable throughout the study. Prothrombin and partial thromboplastin time were unaffected at the peak
of T cell expansion and after contraction. None of the animals experienced weight loss, morbidity or unexpected mortality. CER-1236 T
cells showed a restricted pattern of tissue distribution similar to other T cell products and did not result in tissue damage with no
histological abnormalities observed in any organ evaluated, including heart, lung, liver, kidney and brain.
CER-1236
Clinical Development Strategy
Based
on the extensive preclinical data that we have assembled regarding the use of CER-1236 T cells to combat cancer, we currently anticipate
filing an initial IND in 2024 to commence clinical trials with our initial treatment target being patients suffering from relapsed, or
refractory AML as well as certain B cell lymphomas with unmet medical need. We subsequently intend to expand the clinical development
of CER-1236 to include solid tumors such as NSCLC and ovarian cancer. We expect these clinical trials to evaluate the safety, the potential
therapeutic utility and applicable dose of CER-1236. In addition, we anticipate that these clinical trials may provide insight into the
possible use of CER-1236 to treat an array of hematologic and solid tumors. We believe this drug candidate has the potential to be a
therapy for the unmet needs of targeted indications, if approved, and by leveraging the innate immune system’s phagocytic capabilities,
could be differentiated by its safety, tolerability, efficacy and clinical benefit over current therapeutic approaches, which have been
observed in preclinical studies. None of the abovementioned statements regarding any of our products in development are intended to be
a prediction or conclusion of efficacy. No clinical trials on our product candidates have commenced so no conclusions relating to such
attributes can be made.
Disease
background
Acute
Myeloid Leukemia
Approximately, 20,000
patients in the U.S. are diagnosed with AML annually. In adults, AML, characterized by the rapid buildup of abnormal myeloid cells in
the bone marrow and blood, is the most common acute leukemia worldwide. In children and young adults under 20 years old AML
comprises 74% of acute leukemia cases. Despite the many available treatments for AML, prognosis for patients remains poor. There are
several molecular alterations of AML that make it difficult to treat with individual therapies. The process of categorizing the
disease state as well a patient’s degree of “fitness” for toxic chemotherapeutic regimens is the subject of
ongoing debate and discussion. Moreover, the development of engineered T cell therapies for AML has proven difficult in part due to
the identification of suitable target antigens.
B cell
lymphoma
B
cell lymphomas include patients diagnosed with Hodgkin’s disease and those diagnosed with non-Hodgkin’s lymphoma (“NHL”).
In the U.S., the American Cancer Society estimates that in 2023, approximately 8,800 cases of Hodgkin’s lymphoma and 81,000 cases
of NHL will be diagnosed, with the number of new diagnoses expected to increase annually. Aggressive B cell lymphomas are a heterogenous
group of cancers that arise from B lymphocytes in various stages of development that make up part of the immune system. Included in this
group is DLBCL and its variants, MCL, Burkitt lymphoma and B cell lymphoblastic lymphoma. There are an estimated 15,000 patients receiving
second or third-line therapies for refractory or recurrent NHL.
We
intend to focus the initial development of CER-1236 on the lymphoid malignancies MCL and CLL, a malignancy of mature B cells. MCL is
a rare and difficult-to-treat B cell lymphoma with a relapsing and remitting clinical course. Most cases of MCL are diagnosed with advanced-stage
disease. Extranodal involvement is common, including involvement of the bone marrow, the gastrointestinal tract and peripheral blood
which can result in significant morbidity. MCL accounts for approximately 6% of all cases of NHL diagnosed annually. CLL tends to progress
slowly, with a benign phase followed by a terminal phase marked by progressive disease resistant to treatment. The course of CLL is complicated
by immune dysfunction, which leads to an increased risk of infection, autoimmune complications and other cancers. An estimated 19,000
new cases of CLL are diagnosed annually in the U.S. and CLL is the cause of approximately 4,300 deaths per year.
Current
therapies and their limitations
Until
recent years, AML has been treated with decades-old combination chemotherapy regimens, including cytarabine and anthracycline. This
regimen has about a 70-80% complete response (“CR”) rates of adults younger than 60 years and 40-60% of fit
adults older than 60 years old. For those eligible for the chemotherapy regimen and experiencing a CR, many patients with adverse
features (70%) undergo allogeneic HSCT which, in some patients are “curative.” Unfortunately, a significant proportion (up
to 50%) of AML patients are over the age of 65 and are “unfit” for intensive chemotherapy, requiring different treatment
approaches for medically unfit patients. The treatment landscape for older unfit adults with AML fundamentally changed with the recent
availability of new drugs, in particular the oral B-cell lymphoma 2 inhibitor venetoclax. Venetoclax is used in conjunction with azacytidine
to treat these patients, with a complete response rate ~65%. However the majority of adult patients with AML experience relapse despite
initially attaining CR; a venetoclax-based doublet therapy for medically less-fit adults carries a median survival of ~14.7 months
and 4-year survival of less than 20%. The prognosis for patients who are refractory to or relapse after frontline azacitidine venetoclax
is dismal with median overall survival of 2.4 months, making this an area of high unmet need. Such patients who do not respond to
frontline therapy with azacitidine or venetoclax, and the subset who do not respond to targeted therapies, e.g., IDH1/2 inhibitors, are
candidates for investigational trials. To date, there are no approved cell therapeutic approaches to treat AML.
Treatment
of NHL is dependent on disease designation. Indolent disease may be treated with localized radiation or simply monitored for disease
progression, at which time the disease is often treated with rituximab, with or without chemotherapy. Aggressive disease is treated
with chemotherapy if diagnosed in the earlier stages of disease progression or with a combination of rituximab and chemotherapy if
diagnosed in the more advanced stages. Targeted therapeutics, including the Bruton Tyrosine Kinase (“BTK”) inhibitors, may be used as first line therapy
or as treatment for refractory or relapsed disease. These neoplasms are typically characterized by rapid progressive disease and,
although often potentially curable, are associated with relatively short survival of the patient in the absence of successful
therapy.
While
novel agents, including chemoimmunotherapy, targeted agents and cellular therapy, have transformed the care of patients with MCL, therapeutic
resistance remains a challenge in relapsed or refractory MCL, particularly among patients whose disease characteristics designate them
as high risk. Several approaches may be employed as second-line therapy for patients who relapse or progress on first-line therapy, including
induction with alternate chemotherapies, and targeted therapeutics such as bortezomib, lenalidomide in combination with the monoclonal
antibody rituximab, and BTK inhibitors. The use of a BTK inhibitor is generally the preferred second-line therapy and may also be used
as third-line therapy in patients who have not been previously administered a BTK inhibitor. CD19 directed CAR-T cell therapy is the
recommended third-line treatment for patients who relapse or progress after the administration of chemoimmunotherapy and a BTK inhibitor.
Autologous or allogeneic stem cell transplant is another treatment option for patients who relapse.
The
management of CLL has evolved rapidly over the past decade with newer, targeted therapeutics becoming the standard of care for a significant
majority of previously untreated patients. Options for therapy at relapse include the BTK inhibitors, BCL-2 inhibitors, P13Kδ inhibitors.
Existing
FDA-approved CD19-targeted CAR-T cell therapies produce overall response rates between 50% and 80%. Dosing with brexucabtagene autoleucel
resulted in progression free survival of 25.8 months and overall survival of 46.6 months in patients with MCL and the National
Cancer Care Network has made the treatment its recommended salvage therapy for eligible patients. CAR-T cell therapy has also demonstrated
efficacy in treating aggressive and indolent lymphoma subpopulations and is currently being evaluated as a treatment for CLL. Yet
while these treatments have transformed care, durable responses are often elusive. Moreover, they have a high frequency of acute multi-organ
complications, limiting their use in chronically ill and elderly patients. As such, a significant medical need still exists in refractory
or relapsed patients, particularly in patients whose disease is characterized by high-risk features.
Our therapeutic
approach and development program
We
anticipate the design of the clinical development program for CER-1236 to enable our evaluation of its therapeutic utility in treating
both hematologic and solid tumors, as the capacity of a single therapeutic construct to provide clinical benefit across this diversity
of tumor types would represent a significant advance in cancer immunotherapy. Due to the therapy’s novel mechanism of action, engaging
both the innate and the adaptive immune response, and the broad expression profile of PS on a variety of hematologic and solid tumors,
we intend to employ an adaptive Phase 1 trial design to evaluate patient response to CER-1236. As such, the dosing protocol will
emphasize a gradual increase in the delivered dose with the objective of achieving a clinical signal, while ensuring patient safety.
We also intend our Phase 1 trial design to enable an evaluation of appropriate dosing strategies to optimize CER-T engagement and
proliferation.
To
enhance patient recruitment opportunities, we intend to enroll AML patients who are relapsed and refractory to chemotherapy and eligible
for HSCT. While we expect the majority of our initial enrollments to be with AML patients, we also intend to make all B cell lymphoma
patients eligible to enroll as initial participants in our Phase 1 trial. With safe dosage established in these first patients,
our intent is to subsequently evaluate the use of CER-1236 as monotherapy in AML, MCL and CLL, and in combination with a BTK inhibitor
in select patients. We envision each of the AML, MCL and CLL treatment cohorts to involve an additional three to five patients. Our objective
with these cohorts is to assess safety and CER-T cell proliferation post infusion.
We
believe, subject to discussions with the FDA and other regulatory authorities, that there may be a full development path to registration
and use in the larger AML or relapsed, refractory B cell lymphoma patient populations on achieving positive safety data along with indications
of therapeutic benefit in these initial trial cohorts. We believe CER-1236 may provide significant treatment advantages over currently
available therapeutics, including CAR-T therapy as a result of its potential to enhance objective response rates and the duration of
response related to the comprehensive, coordinated engagement of the innate and adaptive immune systems and a sustained signaling environment.
We believe this novel mechanism of action will enable our advance of a single therapeutic construct to address the substantial unmet
need for a safe and effective cell therapy offering an improved therapeutic profile, despite significant competition. We subsequently
anticipate initiating clinical trials for additional indications, including the possible application of CER-1236 in the treatment of
certain solid tumors such as EGFR mutation positive NSCLC and ovarian cancer.
Manufacturing
Strategy
The
manufacture of product candidates derived from our autologous CER-1236 T cells involves the same type of equipment, materials and protocols
already used in the manufacture of currently FDA-approved CAR-T cell therapies, which we believe will provide us numerous benefits. We
are planning for CER-1236 cell product to be manufactured using an automated closed process, with product manufacture continuous from
bulk harvested cells through to cryopreserved drug product bags. There are multiple factors involved in the manufacturing process needed
to ensure proper CER-T cell cryopreservation both preceding and following freezing, including the thawing process and post-thaw handling
prior to patient administration. These factors are well understood and procedures have been identified to optimize yield, activity, stability
and consistency. In addition, we may be able to take advantage of the increasing regulatory familiarity with these established protocols.
Our expected manufacturing process embraces a fully automated, closed-system design intended to minimize exposure to potential contaminants
and ensure consistent successful manufacture of the product. The product will be manufactured in a contract manufacturing facility which
maintains a quality system compliant with current Good Manufacturing Practice (“cGMP”) requirements.
Lentivirus
containing CER-1236 will be produced following a cGMP process using cGMP plasmids.
We
have entered into a contract manufacturing agreement related to the production of drug product for our clinical trials, and we anticipate
entering into similar arrangements regarding plasmid, viral vector and final drug product manufacture for drug product to be used in
subsequent clinical trial phases in the future. We intend to advance related process development work both internally and with our contract
manufacturing organization (“CMO”) partners. In the event a product candidate receives regulatory approval, we anticipate
entering into contract manufacturing agreements with one or more CMOs to support product launch and commercial manufacture.
Intellectual
Property
Intellectual
property is of vital importance in our field and in biotechnology generally. Our commercial success will depend in part on obtaining
and maintaining patent protection for our current and future product candidates. We seek to protect and enhance proprietary technology,
inventions, and improvements that are commercially important to the development of our business by seeking, maintaining, and defending
our patent rights. When available to expand market exclusivity, our strategy is to obtain or license additional intellectual property
related to current or contemplated development platforms, core elements of technology, and/or clinical candidates. We will also seek
to rely on regulatory protection afforded through inclusion in expedited development and review, data exclusivity, market exclusivity,
and patent term extensions, where available. In addition to patent protection, we also may rely on trademark registration, trade secrets,
know-how, other proprietary information, and continuing technological innovation to develop and maintain our competitive position. We
seek to protect and maintain the confidentiality of proprietary information to protect aspects of our business that are not amenable
to, or that we do not consider appropriate for, patent protection.
The
term of individual patents depends upon the legal term of the patents in the countries in which they are obtained. In most countries
in which we file, including the United States, the patent term is 20 years from the earliest date of filing a non-provisional
patent application. In the United States, a patent’s term may be lengthened by patent term adjustment, which compensates a
patentee for administrative delays by the U.S. Patent and Trademark Office (“USPTO”) in examining and granting a patent,
or may be shortened if a patent is terminally disclaimed over an earlier filed patent. In the United States, the patent term of
a patent that covers an FDA-approved drug may also be eligible for patent term extension, which permits patent term restoration as compensation
for the patent term lost during the FDA regulatory review process. The Hatch-Waxman Act permits a patent term extension of up to five years
beyond the expiration of the patent. The length of the patent term extension is related to the length of time the drug is under regulatory
review. Patent term extension cannot extend the remaining term of a patent beyond a total of 14 years from the date of product approval,
only one patent applicable to an approved drug may be extended, and only those claims covering the approved drug, a method for using
it, or a method for manufacturing it may be extended. Similar provisions are available in Europe and other foreign jurisdictions to extend
the term of a patent that covers an approved drug. In the future, if and when our product candidates receive FDA approval, we expect
to apply for patent term extensions on patents covering those product candidates. We plan to seek patent term extensions to any issued
patents we may obtain in any jurisdiction where such patent term extensions are available.
In
some instances, we submit patent applications directly with the USPTO as provisional patent applications. Corresponding non-provisional
patent applications must be filed not later than 12 months after the provisional application filing date. While we intend to timely
file non-provisional patent applications relating to our provisional patent applications, we cannot predict whether any such patent applications
will result in the issuance of patents that provide us with any competitive advantage.
We
will file U.S. non-provisional applications and Patent Cooperation Treaty (“PCT”) applications that claim the benefit
of the priority date of earlier filed provisional applications, when applicable. The PCT system allows a single application to be filed
within 12 months of the original priority date of the patent application, and to designate all of the PCT member states in which
national patent applications can later be pursued based on the international patent application filed under the PCT. The PCT searching
authority performs a patentability search and issues a non-binding patentability opinion which can be used to evaluate the chances of
success for the national applications in foreign countries prior to having to incur the filing fees. Although a PCT application does
not issue as a patent, it allows the applicant to seek protection in any of the member states through national-phase applications. At
the end of the period of two and a half years from the first priority date of the patent application, separate patent applications
can be pursued in any of the PCT member states either by direct national filing, or in some cases, by filing through a regional patent
organization, such as the European Patent Office. The PCT system delays expenses, allows a limited evaluation of the chances of success
for national/regional patent applications, and enables substantial savings where applications are abandoned within the first two and
a half years of filing.
For
all patent applications, we determine claiming strategy on a case-by-case basis. Advice of counsel and our business model and needs are
always considered. We continuously reassess the number and type of patent applications, as well as the scope of our patent claims to
pursue coverage and value for our processes and compositions, given existing patent office rules and regulations. Further, claims may
be modified during patent prosecution to meet our intellectual property and business needs.
We
have sought patent protection in the United States related to the CER-1236 T cell technology platform and its constructs, as well
as their use as individual cellular compositions and product candidates targeting specific diseases. We also intend to seek patent protection
related to the processes and materials used in CER-1236 T cell expression as well as its use in combination therapies. As of the date
of this Annual Report, our patent portfolio consists of two issued U.S. patents, one of which relates to CER-1236, 11 pending U.S. applications,
seven granted foreign applications (in Europe, Germany, Spain, France, UK, Italy, and Mexico) and 29 pending foreign applications (in
China, Japan, Canada, Hong Kong, and Israel). U.S. Patent Application Number 17/400,082 was allowed and later issued on May 23,
2023 as U.S. Patent Number 11,655,282. This patent provides coverage over our CER-1236 product candidate and includes claims directed
to a CER comprising, at least in part, Tim-4, a phosphatidylserine binding domain, its sequence, and various Tim-4 proteins. These patents
and applications, if and when issued, are projected to expire from 2037 to 2042, prior to consideration of any additional patent term.
We intend to pursue, when possible, further composition, method of use, dosing, formulation, and other patent protection directed to
our current and new product candidates. We may also pursue patent protection with respect to manufacturing and drug development processes
and technology.
The
following issued patents are directed at a composition of matter and provide coverage over our CER-1236 T cell candidate:
U.S.
Patent No. 11,655,282, having an anticipated expiration date of September 26, 2037; and
EP
Patent No. 3,519,441 (validated in the United Kingdom, France, Spain, Germany, and Italy), having an anticipated expiration date of September 26,
2037.
Competition
The
biotechnology and pharmaceutical industries have made substantial investments in recent years into the rapid development of novel
immunotherapies for the treatment of a range of pathologies, including cancers, making this a highly competitive market.
We
face substantial competition from multiple sources, including large and specialty pharmaceutical, biopharmaceutical and biotechnology
companies, academic research institutions and governmental agencies, and public and private research institutions. Our competitors compete
with us based on the specific technologies employed, and on the stage of product candidate development. In addition, many small biotechnology
companies have formed collaborations with large, established companies to (i) obtain support for their research, development, and
commercialization of products, or (ii) combine several treatment approaches to develop longer lasting or more efficacious treatments
that may potentially directly compete with our current or future product candidates.
In
addition to the current standard of care treatments for patients with cancer, numerous commercial and academic preclinical studies and
clinical trials are being undertaken by a large number of parties to assess novel technologies and product candidates in the field of
immunotherapy. Results from these studies and trials have fueled increasing levels of interest in the field of immunotherapy. Accordingly,
we face competition from numerous pharmaceutical and biotechnology entities related to the development of cellular-based therapies to
treat cancer. We expect to face competition from other companies developing TCR T therapies, such as Adaptimmune Therapeutics, plc GlaxoSmithKline
plc, MediGene AG, TCR2 Therapeutics Inc., TScan Therapeutics Inc. and Ziopharm Oncology, Inc. We also may compete with other T cell therapy
companies with target discovery platforms, such as Adaptive Therapeutics, Inc., Immatics, N.V., 3T Biosciences, Inc., and Sana Biotechnology,
Inc., among others. We may also compete against a significant number of companies engaged in the development of autologous and allogeneic
CAR-T, CAR-NK, TIL and T cell engager technologies including larger companies such as Gilead Sciences, Inc., Bristol-Myers Squibb Company
and Amgen, Inc. as well as smaller companies such as Nkarta Inc., Allogene Therapeutics Inc., Century Therapeutics Inc., and Fate Therapeutics
Inc., among others.
Many
of our competitors, either alone or in combination with their respective strategic partners, have significantly greater financial resources
and expertise in R&D, manufacturing, the regulatory approval process, and marketing than we do. Mergers and acquisitions
activity in the pharmaceutical, biopharmaceutical, and biotechnology sector is likely to result in greater resource concentration among
a smaller number of our competitors. Smaller or early-stage companies may also prove to be significant competitors, particularly through
sizeable collaborative arrangements with established companies. These competitors also compete with us in recruiting and retaining qualified
scientific and management personnel, establishing clinical trial sites and patient registration for clinical trials, and acquiring technologies
complementary to, or necessary for, our programs.
Our
commercial opportunity could be reduced or eliminated if one or more of our competitors develop and commercialize products that are safer,
more effective, better tolerated, or of greater convenience or economic benefit than our proposed product offering. Our competitors also
may be in a position to obtain FDA or other regulatory approval for their products more rapidly, resulting in a stronger or dominant
market position before we are able to enter the market. The key competitive factors affecting the success of all of our programs are
likely to be product safety, efficacy, convenience, and treatment cost.
In
the event we receive regulatory approval for any of our product candidates, we will likely compete with other cost-effective and reimbursable
treatments used to treat cancer. The most common treatment modalities for patients with cancer are surgery, radiation, and drug therapy,
including chemotherapy, hormone therapy, biologic therapy, such as monoclonal and bispecific antibodies, immunotherapy, and cell-based
therapy, used alone or in combination to enhance efficacy. Our CER-T cell therapy candidates, if any are approved, may not be competitive
with them. Some of these drugs are branded and subject to patent protection, and others are available on a generic basis. Insurers and
other third-party payors may also encourage the use of generic products or specific branded products. As a result, obtaining market acceptance
of any of our CER-T cell therapies that we successfully introduce to the market may pose challenges.
Government
Regulation
In
the United States, biological products are licensed by the FDA for marketing under the Public Health Service Act (“PHS Act”)
and regulated under the Federal Food, Drug, and Cosmetic Act (“FDCA”). Both the FDCA and the PHS Act and their corresponding
regulations govern, among other things, the testing, manufacturing, safety, purity, potency, efficacy, labeling, packaging, storage,
recordkeeping, distribution, marketing, sales, import, export, reporting, advertising, and other promotional practices involving biological
products. FDA clearance of an IND application must be obtained before commencing clinical testing of biological products. FDA licensure
also must be obtained before marketing of biological products. The process of obtaining regulatory approvals and the subsequent compliance
with appropriate federal, state, local, and foreign statutes and regulations require the expenditure of substantial time and financial
resources.
U.S. Development
Process
The
process required by the FDA before a biological product may be marketed in the United States generally involves the following:
| ● | completion
of nonclinical laboratory tests and animal studies according to Good Laboratory Practices (“GLPs”) and applicable requirements
for the humane use of laboratory animals or other applicable regulations; |
| ● | preparation
of clinical trial material in accordance with cGMPs; |
| ● | submission
to the FDA of an application for an IND application, which must become effective before human clinical trials may begin; |
| ● | approval
by an institutional review board (“IRB”), reviewing each clinical site before each clinical trial may be initiated; |
| ● | performance
of adequate and well-controlled human clinical trials according to Good Clinical Practice (“GCP”) requirements and any additional
requirements for the protection of human research subjects and their health information, to establish the safety, purity, potency, and
efficacy, of the proposed biological product for its intended use; |
| ● | submission
to the FDA of a Biologics License Application (“BLA”) for marketing approval that includes substantive evidence of safety,
purity, potency, and efficacy from results of nonclinical testing and clinical trials; |
| ● | satisfactory
completion of an FDA inspection prior to BLA approval of the manufacturing facility or facilities where the biological product is produced
to assess compliance with cGMPs, to assure that the facilities, methods, and controls are adequate to preserve the biologic’s identity,
strength, quality, and purity; |
| ● | potential
FDA audit of the nonclinical and clinical study sites that generated the data in support of the BLA; |
| ● | potential
FDA advisory committee meeting to elicit expert input on critical issues and including a vote by external committee members; |
| ● | FDA
review and approval, or licensure, of the BLA, and payment of associated user fees, when applicable; and |
| ● | compliance
with any post-approval requirements, including the potential requirement to implement a Risk Evaluation and Mitigation Strategy (“REMS”),
and the potential requirement to conduct post approval studies. |
Before
testing any biological product candidate in humans, the product candidate enters the preclinical testing stage. Nonclinical tests include
laboratory evaluations of product chemistry, pharmacology, toxicity, and formulation, as well as animal studies to assess the potential
safety and activity of the product candidate. The conduct of the nonclinical tests must comply with federal regulations and requirements
including GLPs.
The clinical study sponsor
must submit the results of the nonclinical tests, together with manufacturing information, analytical data, any available clinical data
or literature, and a proposed clinical protocol, to the FDA as part of the IND. Some nonclinical testing typically continues after
the IND is submitted. An IND is an exemption that allows an unapproved product to be shipped in interstate commerce for use in an investigational
clinical trial and a request for FDA authorization to administer an investigational product to humans. The IND automatically becomes effective
30 days after receipt by the FDA, unless the FDA requests certain changes to a protocol before the trial can begin, or the FDA places
the clinical trial on a clinical hold within that 30-day time period. In such a case, the IND sponsor and the FDA must resolve any outstanding
concerns before the clinical trial can begin. The FDA may also impose clinical holds on a biological product candidate at any time before
or during clinical trials due to safety concerns or non-compliance. If the FDA imposes a clinical hold, trials may not recommence without
FDA authorization and then only under terms authorized by the FDA.
Clinical trials may involve
the administration of the biological product candidate to healthy volunteers or subjects under the supervision of qualified investigators.
Clinical trials involving some products for certain diseases, including some rare diseases may begin with testing in patients with the
disease. Clinical trials are conducted under protocols detailing, among other things, the objectives of the clinical trial, dosing procedures,
subject selection, and exclusion criteria, and the parameters to be used to monitor subject safety, including stopping rules that assure
a clinical trial will be stopped if certain adverse events should occur. Each protocol and any amendments to the protocol must be submitted
to the FDA as part of the IND. Clinical trials must be conducted and monitored in accordance with the FDA’s regulations comprising
the GCP requirements, including the requirement that all research subjects or his or her legal representative provide informed consent.
Further, each clinical trial must be reviewed and approved by an independent IRB, at or servicing each institution at which the clinical
trial will be conducted. An IRB is charged with protecting the welfare and rights of study participants and considers such items as whether
the risks to individuals participating in the clinical trials are minimized and are reasonable in relation to anticipated benefits. The
IRB also approves the form and content of the informed consent that must be signed by each clinical trial subject or his or her legal
representative and must monitor the clinical trial until completed. Additionally, some trials are overseen by an independent group of
qualified experts organized by the trial sponsor, known as a data safety monitoring board or committee.
Human clinical trials are
typically conducted in three sequential phases that may overlap or be combined:
| ● | Phase 1. The biological product is initially
introduced into healthy human subjects and tested for safety. In the case of some products for rare diseases, the initial human testing
is often conducted in patients. |
| ● | Phase 2. The biological product is evaluated
in a limited patient population to identify possible adverse effects and safety risks, preliminarily evaluate the efficacy of the product
for specific targeted diseases, and determine dosage tolerance, optimal dosage, and dosing schedule. |
| ● | Phase 3. Clinical trials are undertaken
to further evaluate dosage, clinical efficacy, potency, and safety in an expanded patient population at geographically dispersed clinical
trial sites. These clinical trials are intended to establish the overall risk/benefit ratio of the product and provide an adequate basis
for product labeling. In biologics for rare diseases where patient populations are small and there is an urgent need for treatment, Phase 3
trials might not be required if an adequate risk/benefit can be demonstrated by the Phase 2 trial. |
Post-approval clinical trials,
sometimes referred to as Phase 4 clinical trials, may be conducted after initial marketing approval. These clinical trials are used
to gain additional experience from the treatment of patients in the intended therapeutic indication, particularly for long-term safety
follow-up.
During all phases of clinical
development, the FDA requires extensive monitoring and auditing of all clinical activities, clinical data, and clinical trial investigators.
Annual progress reports detailing the results of the clinical trials must be submitted to the FDA. Written IND safety reports must
be promptly submitted to the FDA and the investigators for serious and unexpected adverse events, any findings from other studies, tests
in laboratory animals or in vitro testing that suggest a significant risk for human subjects, or any clinically important increase in
the rate of serious suspected adverse reactions over those listed in the protocol or investigator brochure. The sponsor must submit an
IND safety report within 15 calendar days after the sponsor determines that the information qualifies for such reporting. The sponsor
also must notify the FDA of any unexpected fatal or life-threatening suspected adverse reaction within 7 calendar days after the
sponsor’s initial receipt of the information. Phase 1, Phase 2, and Phase 3 clinical trials may not be completed
successfully within any specified period, if at all. The FDA or the sponsor or its data safety monitoring board may suspend a clinical
trial at any time on various grounds, including a finding that the research subjects or patients are being exposed to an unacceptable
health risk. Similarly, an IRB can suspend or terminate approval of a clinical trial at its institution if the clinical trial is not being
conducted in accordance with the IRB’s requirements or if the biologic has been associated with unexpected serious harm to patients.
Concurrent with clinical
trials, companies usually complete additional animal studies and must also develop additional information about the physical characteristics
of the biologic as well as finalize a process for manufacturing the product in commercial quantities in accordance with cGMP requirements.
To help reduce the risk of the introduction of adventitious agents with use of biologics, the PHS Act emphasizes the importance of manufacturing
control for products whose attributes cannot be precisely defined. The manufacturing process must be capable of consistently producing
quality batches of the product candidate and, among other things, the sponsor must develop methods for testing the identity, strength,
quality, potency, and purity of the final biological product. Additionally, appropriate packaging must be selected and tested and stability
studies must be conducted to demonstrate that the biological product candidate does not undergo unacceptable deterioration over its shelf
life.
There are also various laws
and regulations regarding laboratory practices, the experimental use of animals, and the use and disposal of hazardous or potentially
hazardous substances in connection with the research. In each of these areas, the FDA and other regulatory authorities have broad regulatory
and enforcement powers, including the ability to levy fines and civil penalties, suspend or delay issuance of approvals, seize or recall
products, and withdraw approvals.
Information about certain
clinical trials must be submitted within specific timeframes for public dissemination on the clinicaltrials.gov website. Sponsors or distributors
of investigational products for the diagnosis, monitoring, or treatment of one or more serious diseases or conditions must also have a
publicly available policy on evaluating and responding to requests for expanded access requests.
U.S. Review and Approval Processes
After the completion of clinical
trials of a biological product, FDA approval of a BLA must be obtained before commercial marketing of the product begins. The BLA must
include results of product development, laboratory, and animal studies, human studies, information on the manufacture and composition
of the product, proposed labeling, and other relevant information. The testing and approval processes require substantial time and effort
and there can be no assurance that the FDA will accept the BLA for filing and, even if filed, that any approval will be granted on a timely
basis, if at all.
Under the Prescription Drug
User Fee Act, as amended (“PDUFA”), each BLA may be accompanied by a significant user fee. Under federal law, the submission
of most applications is subject to an application user fee. The sponsor of an approved application is also subject to an annual program
fee. Fee waivers or reductions are available in certain circumstances, including a waiver of the application fee for the first application
filed by a small business. Additionally, no user fees are assessed on BLAs for product candidates designated as orphan drugs, unless the
product candidate also includes a non-orphan indication.
Within 60 days following
submission of the application, the FDA reviews a BLA submitted to determine if it is substantially complete before the agency accepts
it for filing. The FDA may refuse to file any BLA that it deems incomplete or not properly reviewable at the time of submission and may
request additional information. In this event, the BLA must be resubmitted with the additional information. The resubmitted application
is also subject to review before the FDA accepts it for filing. The application also needs to be published and submitted in an electronic
format that can be processed through the FDA’s electronic systems. If the electronic submission is not compatible with the FDA’s
systems, the BLA can be refused for filing. Once the submission is accepted for filing, the FDA begins an in-depth substantive review
of the BLA. The FDA reviews the BLA to determine, among other things, whether the proposed product is safe, potent, and effective,
for its intended use, and has an acceptable purity profile, and whether the product is being manufactured in accordance with cGMPs to
assure and preserve the product’s identity, safety, strength, quality, potency and purity. The FDA may refer applications for novel
products or products that present difficult questions of safety or efficacy to an advisory committee, typically a panel that includes
clinicians and other experts, for review, evaluation, and a recommendation as to whether the application should be approved and under
what conditions. The FDA is not bound by the recommendations of an advisory committee, but it considers such recommendations carefully
when making decisions. During the biological product approval process, the FDA also will determine whether a REMS is necessary to assure
the safe use of the biological product. If the FDA concludes a REMS is needed, the sponsor of the BLA must submit a proposed REMS; the
FDA will not approve the BLA without a REMS, if required.
Before approving a BLA, the
FDA may inspect the facilities at which the product is manufactured. The FDA will not approve the product unless it determines that the
manufacturing processes and facilities are in compliance with cGMP requirements and adequate to assure consistent production of the product
within required specifications. Additionally, before approving a BLA, the FDA will typically inspect one or more clinical trial sites
to assure that the clinical trials were conducted in compliance with IND study requirements and GCP requirements. To assure cGMP and GCP
compliance, an applicant must incur significant expenditure of time, money, and effort in the areas of training, record keeping, production
and quality control.
Notwithstanding the submission
of relevant data and information, the FDA may ultimately decide that the BLA does not satisfy its regulatory criteria for approval and
deny approval. Data obtained from clinical trials are not always conclusive and the FDA may interpret data differently than the sponsor
interprets the same data. If the agency decides not to approve the BLA in its present form, the FDA will issue a complete response letter
that describes all of the specific deficiencies in the BLA identified by the FDA. The deficiencies identified may be minor, such
as requiring labeling changes, or major, such as requiring additional clinical trials. Additionally, the complete response letter may
include recommended actions that the applicant might take to place the application in a condition for approval. If a complete response
letter is issued, the applicant may either resubmit the BLA, addressing all of the deficiencies identified in the letter, or withdraw
the application.
If a product receives regulatory
approval, the approval may be significantly limited to specific diseases and dosages or the indications for use may otherwise be limited,
which could restrict the commercial value of the product. Further, the FDA may require that certain contraindications, warnings, or precautions
be included in the product labeling. The FDA may impose restrictions and conditions on product distribution, prescribing, or dispensing
in the form of a risk management plan, or otherwise limit the scope of any approval. In addition, the FDA may require post-marketing clinical
trials, sometimes referred to as Phase 4 clinical trials, designed to further assess a biological product’s safety and effectiveness,
and testing and surveillance programs to monitor the safety of approved products that have been commercialized. As a condition for approval,
the FDA may also require additional nonclinical testing as a Phase 4 commitment.
One of the performance goals
agreed to by the FDA under the PDUFA is to review standard BLAs in ten months from filing and priority BLAs in six months from
filing, whereupon a review decision is to be made. The FDA does not always meet its PDUFA goal dates for standard and priority BLAs and
its review goals are subject to change from time to time. The review process and the PDUFA goal date may be extended by three months
if the FDA requests or the BLA sponsor otherwise provides additional information or clarification regarding information already provided
in the submission within the last three months before the PDUFA goal date.
Post-Approval Requirements
Maintaining substantial compliance
with applicable federal, state, and local statutes and regulations requires the expenditure of substantial time and financial resources.
Rigorous and extensive FDA regulation of biological products continues after approval, particularly with respect to cGMP. We will
rely, and expect to continue to rely, on third parties for the production of clinical and commercial quantities of any products that we
may commercialize. Manufacturers of our products are required to comply with applicable requirements in the cGMP regulations, including
quality control and quality assurance and maintenance of records and documentation.
Following approval, the manufacturing
facilities are subject to inspections by the FDA, and such inspections may result in an issuance of FDA Form 483 deficiency observations,
untitled letter, or a warning letter, which can lead to plant shutdown and other more serious penalties and fines. Prior to the institution
of any manufacturing changes, a determination needs to be made regarding whether FDA approval is required in advance. If not done in accordance
with FDA expectations, the FDA may restrict supply and may take further action. Product reports are required to be submitted annually.
Other post-approval requirements applicable to biological products include reporting of cGMP deviations that may affect the identity,
potency, purity, and overall safety of a distributed product, recordkeeping requirements, reporting of adverse events, reporting updated
safety and efficacy information, and complying with electronic record and signature requirements.
After a BLA is approved,
the product also may be subject to official lot release. As part of the manufacturing process, the manufacturer is required to perform
certain tests on each lot of the product before it is released for distribution. If the product is subject to official release by the
FDA, the manufacturer submits samples of each lot of product to the FDA together with a release protocol showing a summary of the history
of manufacture of the lot and the results of all of the manufacturer’s tests performed on the lot. The FDA also may perform certain
confirmatory tests on lots of some products, such as viral vaccines, before releasing the lots for distribution by the manufacturer. In
addition, the FDA may conduct laboratory research related to the regulatory standards on the safety, purity, potency, and effectiveness
of biological products. Systems need to be put in place to record and evaluate adverse events reported by health care providers and patients
and to assess product complaints. An increase in severity or new adverse events can result in labeling changes or product recall. Defects
in manufacturing of commercial products can result in product recalls.
We also must comply with
the FDA’s advertising and promotion requirements, such as those related to direct-to-consumer advertising, the prohibition on promoting
products for uses or inpatient populations that are not described in the product’s approved labeling (known as “off-label
use”), industry-sponsored scientific and educational activities, and promotional activities involving the internet. Discovery of
previously unknown problems or the failure to comply with the applicable regulatory requirements may result in restrictions on the marketing
of a product or withdrawal of the product from the market as well as possible civil or criminal sanctions. Failure to comply with the
applicable U.S. requirements at any time during the product development process, approval process, or after approval may subject
an applicant or manufacturer to administrative or judicial civil or criminal sanctions and adverse publicity. FDA sanctions could include
refusal to approve pending applications, withdrawal of an approval or license revocation, clinical hold, warning or untitled letters,
product recalls, product seizures, total or partial suspension of production or distribution, injunctions, fines, refusals of government
contracts, mandated corrective advertising or communications with doctors, debarment, restitution, disgorgement of profits, or civil or
criminal penalties. Any agency or judicial enforcement action could have a material adverse effect.
Biological product manufacturers
and other entities involved in the manufacture and distribution of approved biological products are required to register their establishments
with the FDA and certain state agencies, and they are subject to periodic unannounced inspections by the FDA and certain state agencies
for compliance with cGMPs and other laws. Accordingly, manufacturers must continue to expend time, money, and effort in the areas of production
and quality control to maintain cGMP compliance. Manufacturers and other parties involved in the drug supply chain for prescription drug
products must also comply with product tracking and tracing requirements and for notifying the FDA of counterfeit, diverted, stolen and
intentionally adulterated products or products that are otherwise unfit for distribution in the United States. Discovery of problems
with a product after approval may result in restrictions on a product, manufacturer, or holder of an approved BLA, including withdrawal
of the product from the market. In addition, changes to the manufacturing process or facility generally require prior FDA approval before
being implemented, and other types of changes to the approved product, such as adding new indications and additional labeling claims,
are also subject to further FDA review and approval.
Orphan Drug Designation
Under the Orphan Drug Act,
the FDA may grant orphan drug designation (“ODD”), to a biological product intended to treat a rare disease or condition,
which is generally a disease or condition that affects fewer than 200,000 individuals in the United States, or more than 200,000
individuals in the United States and for which there is no reasonable expectation that the cost of developing and making a biological
product available in the United States for this type of disease or condition will be recovered from sales of the product. ODD must
be requested before submitting a BLA. After the FDA grants ODD, the identity of the therapeutic agent and its potential orphan use
are disclosed publicly by the FDA. ODD does not convey any advantage in or shorten the duration of the regulatory review and approval
process.
If a product that has ODD
receives the first FDA approval for the disease or condition for which it has such designation, the product is entitled to orphan product
exclusivity, which means that the FDA may not approve any other applications to market the same biological product for the same indication
for seven years, except in limited circumstances, such as not being able to supply the product for patients or showing clinical superiority
to the product with orphan exclusivity.
Competitors, however, may
receive approval of different products for the indication for which the orphan product has exclusivity or obtain approval for the same
product but for a different indication for which the orphan product has exclusivity. Orphan product exclusivity also could block the approval
of one of our products for seven years if a competitor obtains approval of the same biological product as defined by the FDA or if
our product candidate is determined to be contained within the competitor’s product for the same indication or disease. If a biological
product designated as an orphan product receives marketing approval for an indication broader than what is designated, it may not be entitled
to orphan product exclusivity.
Expedited Review and Approval Programs
The FDA has various programs,
including fast track designation, priority review, accelerated approval, and breakthrough therapy designation, that are intended to expedite
or simplify the process for the development and FDA review of biological products that are intended for the treatment of serious or life-threatening
diseases or conditions and demonstrate the potential to address unmet medical needs. The purpose of these programs is to provide important
new biological products to patients earlier than under standard FDA review procedures. To be eligible for a fast track designation, the
FDA must determine, based on the request of a sponsor, that a biological product is intended to treat a serious or life-threatening disease
or condition and demonstrates the potential to address an unmet medical need. The FDA will determine that a product will fill an unmet
medical need if it will provide a therapy where none exists or provide a therapy that may be potentially superior to existing therapy
based on efficacy or safety factors. In addition to other benefits, such as the ability to have greater interactions with the FDA, the
FDA may initiate review of sections of a fast track BLA before the application is complete, a process known as rolling review.
The FDA may give a priority
review designation, such as a rare pediatric disease designation, to biological products that treat a serious condition and, if approved,
would provide a significant improvement in safety or effectiveness. A priority review means that the goal for the FDA to review an application
is six months, rather than the standard review of ten months under current PDUFA guidelines. Most products that are eligible
for fast track designation may also be considered appropriate to receive a priority review. In addition, biological products studied for
their safety and effectiveness in treating serious or life-threatening illnesses and that provide meaningful therapeutic benefit over
existing treatments may receive accelerated approval and may be approved on the basis of adequate and well-controlled clinical trials
establishing that the biological product has an effect on a surrogate endpoint that is reasonably likely to predict clinical benefit,
or on a clinical endpoint that can be measured earlier than irreversible morbidity or mortality, that is reasonably likely to predict
an effect on irreversible morbidity or mortality or other clinical benefit, taking into account the severity, rarity, or prevalence of
the condition and the availability or lack of alternative treatments. As a condition of approval, the FDA may require a sponsor of a biological
product receiving accelerated approval to perform adequate and well-controlled post-marketing studies to verify and describe the predicted
effect on irreversible morbidity or mortality or other clinical endpoint. Under the Food and Drug Omnibus Reform Act of 2022 (“FDORA”),
the FDA may require, as appropriate, that such trials be underway prior to approval or within a specific time period after the date of
approval for a product granted accelerated approval.
Under FDORA, the FDA has
increased authority for expedited procedures to withdraw approval of a drug or indication approved under accelerated approval if, for
example, the confirmatory trial fails to verify the predicted clinical benefit of the product. In addition, for products being considered
for accelerated approval, the FDA generally requires, unless otherwise informed by the agency, that all advertising and promotional materials
intended for dissemination or publication within 120 days of marketing approval be submitted to the agency for review during the
pre-approval review period.
Moreover, a sponsor can request
designation of a product candidate as a “breakthrough therapy.” A breakthrough therapy is defined as a drug or biological
product that is intended, alone or in combination with one or more other drugs or biologics, to treat a serious or life-threatening disease
or condition, and preliminary clinical evidence indicates that the drug or biological product may demonstrate substantial improvement
over existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical
development. Drug and biological products designated as breakthrough therapies are also eligible for accelerated approval. The FDA must
take certain actions, such as holding timely meetings and providing advice, intended to expedite the development and review of an application
for approval of a breakthrough therapy.
Even if a product qualifies
for one or more of these programs, the FDA may later decide that the product no longer meets the conditions for qualification or decides
that the time period for FDA review or approval will not be shortened. Furthermore, fast-track designation, priority review, accelerated
approval, and breakthrough therapy designation do not change the standards for approval and may not ultimately expedite the development
or approval process.
Biologics Price Competition and Innovation
Act
The Biologics Price Competition
and Innovation Act of 2009 (“BPCIA”), which was enacted as part of the Patient Protection and Affordable Care Act, as amended
by the Health Care and Education Reconciliation Act of 2010 (collectively, the “Affordable Care Act”), created an
abbreviated approval pathway for biological products that are demonstrated to be “biosimilar” or “interchangeable”
with an FDA-licensed reference biological product via an approved BLA. Biosimilarity to an approved reference product requires that
there be no differences in conditions of use, route of administration, dosage form, and strength, and no clinically meaningful differences
between the biological product and the reference product in terms of safety, purity, and potency. Biosimilarity is demonstrated in steps
beginning with rigorous analytical studies or “fingerprinting”, in vitro studies, in vivo animal studies, and generally at
least one clinical study. If at any point in the stepwise biosimilarity process a significant difference is observed, then the products
are not biosimilar, and the development of a standalone BLA is necessary. In order to meet the higher hurdle of interchangeability, a
sponsor must demonstrate that the biosimilar product can be expected to produce the same clinical result as the reference product, and
for a product that is administered more than once, that the risk of switching between the reference product and biosimilar product is
not greater than the risk of maintaining the patient on the reference product. Complexities associated with the larger, and often more
complex, structures of biological products, as well as the process by which such products are manufactured, pose significant hurdles to
implementation that are still being evaluated by the FDA. Under the BPCIA, a reference biologic is granted 12 years of exclusivity
from the time of first licensure of the reference product.
Regulation Outside of the United States
In addition to regulations
in the United States, we are subject to a variety of regulations in other jurisdictions governing clinical studies, commercial sales,
and distribution of our products. Most countries outside of the United States require that clinical trial applications be submitted
to and approved by the local regulatory authority for each clinical study. In the European Union (the “European Union”), for
example, an application must be submitted to the national competent authority and an independent ethics committee in each country in which
we intend to conduct clinical trials, much like the FDA and IRB, respectively. Under the Clinical Trials Regulation (EU) No 536/2014,
which replaced the Clinical Trials Directive 2001/20/EC on January 31, 2022, a single application is now made through the Clinical
Trials Information System (“CTIS”) for clinical trial authorization in up to 30 EU/EEA countries at the same time and with
a single set of documentation.
The assessment of applications
for clinical trials is divided into two parts (Part I contains scientific and medicinal product documentation and Part II contains
the national and patient-level documentation). Part I is assessed by a coordinated review by the competent authorities of all European
Union member states (the “ Member States”) in which an application for authorization of a clinical trial has been submitted
(Member States concerned) of a draft report prepared by a reference Member State. Part II is assessed separately by each Member State
concerned. The role of the relevant ethics committees in the assessment procedure continues to be governed by the national law of the
Member State concerned, however overall related timelines are defined by the Clinical Trials Regulation. The Clinical Trials Regulation
also provides for simplified reporting procedures for clinical trial sponsors.
In addition, whether or not
we obtain FDA approval for a product, we must obtain approval of a product by the comparable regulatory authorities of countries outside
the United States before we can commence marketing of the product in those countries. The approval process and requirements vary
from country to country, so the number and type of nonclinical, clinical, and manufacturing studies needed may differ, and the time may
be longer or shorter than that required for FDA approval.
To obtain regulatory approval
of our medicinal products under the European Union regulatory system, we are required to submit a marketing authorization application
(“MAA”), to be assessed in the centralized procedure. The centralized procedure allows applicants to obtain a marketing authorization
(“MA”) that is valid throughout the European Union, and the additional Member States of the European Economic Area (Iceland,
Liechtenstein and Norway) (“EEA”). It is compulsory for medicinal products manufactured using biotechnological processes,
orphan medicinal products, advanced therapy medicinal products (gene-therapy, somatic cell-therapy or tissue-engineered medicines) and
medicinal products containing a new active substance which is not authorized in the European Union and which is intended for the treatment
of HIV, AIDS, cancer, neurodegenerative disorders, auto-immune and other immune dysfunctions, viral diseases or diabetes. The centralized
procedure is optional for any other products containing new active substances not authorized in the European Union or for products which
constitute a significant therapeutic, scientific, or technical innovation or for which a centralized authorization is in the interests
of patients at European Union level. When a company wishes to place on the market a medicinal product that is eligible for the centralized
procedure, it sends an application directly to the EMA, to be assessed by the Committee for Medicinal Products for Human Use (“CHMP”).
The CHMP is responsible for conducting the assessment of whether a medicine meets the required quality, safety, and efficacy requirements,
and whether the product has a positive risk/benefit profile. The procedure results in a European Commission decision, which is valid in
all European Union Member States. The centralized procedure is as follows: full copies of the MAA are sent to a rapporteur and a co-rapporteur
designated by the competent European Medicines Agency (“EMA”) scientific committee. They coordinate the EMA’s scientific
assessment of the medicinal product and prepare draft reports. Once the draft reports are prepared (other experts might be called upon
for this purpose), they are sent to the CHMP, whose comments or objections are communicated to the applicant. The rapporteur is therefore
the privileged interlocutor of the applicant and continues to play this role, even after the MA has been granted.
The rapporteur and co-rapporteur
then assess the applicant’s replies, submit them for discussion to the CHMP, and taking into account the conclusions of this debate,
prepare a final assessment report. Once the evaluation is completed, the CHMP gives a favorable or unfavorable opinion as to whether to
grant the authorization. When the opinion is favorable, it shall include the draft summary of product characteristics (“SmPC”),
the package leaflet, and the texts proposed for the various packaging materials. The time limit for the evaluation procedure is 210 days
(excluding clock stops, when additional written or oral information is to be provided by the applicant in response to questions asked
by the CHMP). The EMA then has fifteen days to forward its opinion to the European Commission, which will make a binding decision
on the grant of an MA within 67 days of the receipt of the CHMP opinion.
National marketing authorizations,
which are issued by the competent authorities of the Member States of the European Union and only cover their respective territory, are
available for products not falling within the mandatory scope of the centralized procedure. Where a product has already been authorized
for marketing in a Member State of the European Union, this national authorization can be recognized in other Member States through the
mutual recognition procedure. If the product has not received a national authorization in any Member State at the time of application,
it can be approved simultaneously in various Member States through the decentralized procedure.
In the European Union, new
chemical entities (including both small molecules and biological medicinal products) approved on the basis of a complete and independent
data package qualify for eight years of data exclusivity upon marketing authorization and an additional two years of market exclusivity.
Data exclusivity, if granted, prevents generic or biosimilar applicants from referencing the innovator’s pre-clinical and clinical
trial data contained in the dossier of the reference product when applying for a generic or biosimilar MA, for a period of eight years
from the date on which the reference product was first authorized in the European Union. During the additional two-year period of market
exclusivity, a generic or biosimilar MAA can be submitted, and the innovator’s data may be referenced, but no medicinal product
can be marketed until the expiration of the market exclusivity. The overall ten-year period will be extended to a maximum of eleven years
if, during the first eight years of those ten years, the MA holder obtains an authorization for one or more new therapeutic indications
which, during the scientific evaluation prior to authorization, is held to bring a significant clinical benefit in comparison with currently
approved therapies. There is no guarantee that a product will be considered by the EMA to be a new chemical entity, and products may not
qualify for data exclusivity. Even if a product is considered to be a new chemical entity so that the innovator gains the prescribed period
of data exclusivity, another company could nevertheless also market another version of the product if such company obtained an MA based
on an MAA with a complete and independent data package of pharmaceutical tests, preclinical tests and clinical trials.
The criteria for designating
an “orphan medicinal product” in the European Union are similar in principle to those in the United States. Under Article 3
of Regulation (EC) 141/2000, a medicinal product may be designated as an orphan medicinal product if it is intended for the diagnosis,
prevention, or treatment of a life-threatening or chronically debilitating condition that affects no more than five in 10,000 persons
in the European Union when the application is made. In addition, orphan designation can be granted if the product is intended for a life
threatening, seriously debilitating, or serious and chronic condition in the European Union and, without incentives, it is unlikely that
sales of the product in the European Union would be sufficient to justify the necessary investment in its development. Orphan designation
is only available if there is no other satisfactory method approved in the European Union of diagnosing, preventing, or treating the applicable
orphan condition, or if such a method exists, the proposed orphan medicinal product will be of significant benefit to patients affected
by such condition, as defined in Regulation (EC) 847/2000.
Orphan designation provides
opportunities for fee reductions, protocol assistance, and access to the centralized procedure. Fee reductions are limited to the first
year after an MA, except for small and medium enterprises. In addition, if a product which has an orphan designation subsequently receives
a centralized MA for the indication for which it has such designation, the product is entitled to orphan market exclusivity, which means
the EMA may not approve any other application to market a similar medicinal product for the same indication for a period of ten years.
A “similar medicinal product” is defined as a medicinal product containing a similar active substance or substances as contained
in an authorized orphan medicinal product, and which is intended for the same therapeutic indication. The exclusivity period may be reduced
to six years if, at the end of the fifth year, it is shown that the designation criteria are no longer met, including where it is
shown that the product is sufficiently profitable not to justify maintenance of market exclusivity. Additionally, an MA may be granted
to a similar medicinal product for the same indication as an authorized orphan product at any time if:
| ● | the second applicant can establish that its product, although
similar to the authorized product, is safer, more effective or otherwise clinically superior; |
| ● | the MA holder of the authorized product consents to a second
orphan medicinal product application; or |
| ● | the MA holder of the authorized product cannot supply enough
orphan medicinal product. |
A pediatric investigation
plan (“PIP”) in the European Union is aimed at ensuring that the necessary data are obtained to support the authorization
of a medicine for children, through studies in children. All applications for MAs for new medicines have to include the results of studies
as described in an agreed PIP, unless the medicine is exempt because of a deferral or waiver. This requirement also applies when an MA
holder wants to add a new indication, pharmaceutical form, or route of administration for a medicine that is already authorized and covered
by intellectual property rights. Several rewards and incentives for the development of pediatric medicines for children are available
in the European Union. Medicines authorized across the European Union with the results of studies from a PIP included in the product information
are eligible for an extension of their supplementary protection certificate (“SPC”) by six months (provided an application
for such extension is made at the same time as filing the SPC application for the product, or at any point up to two years before
the SPC expires). This is the case even when the studies’ results are negative. For orphan medicinal products, the incentive is
an additional two years of market exclusivity. Scientific advice and protocol assistance at the EMA are free of charge for questions
relating to the development of pediatric medicines. Medicines developed specifically for children that are already authorized but are
not protected by a patent or supplementary protection certificate are eligible for a pediatric-use MA (“PUMA”). If a PUMA
is granted, the product will benefit from ten years of market protection as an incentive.
In March 2016, the EMA
launched an initiative, the PRIority Medicines (“PRIME”) scheme, to facilitate development of product candidates in indications,
often rare, for which few or no therapies currently exist. The PRIME scheme is intended to encourage development of products in areas
of unmet medical need and provides accelerated assessment of products representing substantial innovation reviewed under the centralized
procedure. Products from small- and medium-sized enterprises may qualify for earlier entry into the PRIME scheme than larger companies
on the basis of compelling non-clinical data and tolerability data from initial clinical trials. Many benefits accrue to sponsors of product
candidates with PRIME designation, including but not limited to, early and proactive regulatory dialogue with the EMA, frequent discussions
on clinical trial designs and other development program elements, and potentially accelerated MAA assessment once a dossier has been submitted.
Importantly, once a candidate medicine has been selected for the PRIME scheme, a dedicated contact and rapporteur from the CHMP or from
the Committee for Advanced Therapies (“CAT”) are appointed early in the PRIME scheme facilitating increased understanding
of the product at EMA’s committee level. An initial meeting with the CHMP/CAT rapporteur initiates these relationships and includes
a team of multidisciplinary experts at the EMA to provide guidance on the overall development and regulatory strategies. PRIME eligibility
does not change the standards for product approval, and there is no assurance that any such designation or eligibility will result in
expedited review or approval.
The aforementioned European
Union rules are generally applicable in the EEA.
The European Commission introduced
legislative proposals in April 2023 that, if implemented, will replace the current regulatory framework in the European Union for all
medicines (including those for rare diseases and for children). The European Commission has provided the legislative proposals to the
European Parliament and the European Council for their review and approval. In October 2023, the European Parliament published draft reports
proposing amendments to the legislative proposals, which will be debated by the European Parliament. Once the European Commission’s
legislative proposals are approved (with or without amendment), they will be adopted into European Union law.
The United Kingdom left the
European Union on January 31, 2020, and the United Kingdom and the European Union have concluded a trade and cooperation agreement
(“TCA”) which was provisionally applicable since January 1, 2021 and has been formally applicable since May 1, 2021.
The TCA includes specific
provisions concerning pharmaceuticals, which include the mutual recognition of GMP, inspections of manufacturing facilities for medicinal
products and GMP documents issued, but does not provide for wholesale mutual recognition of United Kingdom and European Union pharmaceutical
regulations. At present, Great Britain has implemented European Union legislation on the marketing, promotion and sale of medicinal products
through the Human Medicines Regulations 2012 (as amended). Except in respect of the European Union Clinical Trials Regulation, the regulatory
regime in Great Britain therefore largely aligns with current European Union medicines regulations, however it is possible that these
regimes will diverge more significantly in future now that Great Britain’s regulatory system is independent from the European Union
and the TCA does not provide for mutual recognition of United Kingdom and European Union pharmaceutical legislation. However, notwithstanding
that there is no wholesale recognition of European Union pharmaceutical legislation under the TCA, under a new framework mentioned below
which was put in place by the Medicines and Healthcare products Regulatory Agency (“MHRA”), the United Kingdom’s medicines
regulator, on January 1, 2024, the MHRA may take into account decisions on the approval of MAs from the EMA (and certain other regulators)
when considering an application for a Great Britain MA.
On February 27, 2023,
the United Kingdom government and the European Commission announced a political agreement in principle to replace the Northern Ireland
Protocol (the “Northern Ireland Protocol”) with a new set of arrangements, known as the “Windsor Framework”. This
new framework fundamentally changes the existing system under the Northern Ireland Protocol, including with respect to the regulation
of medicinal products in the United Kingdom. In particular, the MHRA will be responsible for approving all medicinal products destined
for the United Kingdom market (i.e., Great Britain and Northern Ireland), and the EMA will no longer have any role in approving medicinal
products destined for Northern Ireland. A single United Kingdom-wide MA will be granted by the MHRA for all medicinal products to be sold
in the United Kingdom, enabling products to be sold in a single pack and under a single authorization throughout the United Kingdom. The
Windsor Framework was approved by the European Union-United Kingdom Joint Committee on March 24, 2023, so the United Kingdom government
and the European Union will enact legislative measures to bring it into law. On June 9, 2023, the MHRA announced that the medicines aspects
of the Windsor Framework will apply from January 1, 2025.
The MHRA has introduced changes
to national licensing procedures, including procedures to prioritize access to new medicines that will benefit patients, an accelerated
assessment procedure and new routes of evaluation for novel products and biotechnological products. On January 1, 2024, the MHRA put in
place a new international recognition framework under which the MHRA may have regard to decisions on the approval of MAs made by the EMA
and certain other regulators when determining an application for a new Great Britain MA.
There is now no pre-MA orphan
designation in Great Britain. Instead, the MHRA reviews applications for orphan designation in parallel to the corresponding MAA. The
criteria are essentially the same, but have been tailored for the Great Britain market, i.e., the prevalence of the condition in Great
Britain (rather than the European Union) must not be more than five in 10,000. Should an orphan designation be granted, the period or
market exclusivity will be set from the date of first approval of the product in Great Britain or the European Union, wherever is earliest.
Healthcare Laws and Regulations
Sales of our product candidate,
if approved, or any other future product candidate, will be subject to healthcare regulation and enforcement by the federal government
and the states and foreign governments in which we might conduct our business. The healthcare laws and regulations that may affect our
ability to operate include the following:
| ● | The federal Anti-Kickback Statute makes it illegal for any
person or entity to knowingly and willfully, directly or indirectly, solicit, receive, offer, or pay any remuneration that is in exchange
for or to induce the referral of business, including the purchase, order, lease of any good, facility, item or service for which payment
may be made under a federal healthcare program, such as Medicare or Medicaid. The term “remuneration” has been broadly interpreted
to include anything of value; |
| ● | Federal false claims, and false statement laws, including
the federal civil False Claims Act, and Civil Monetary Penalties Law, prohibits, among other things, any person or entity from knowingly
presenting, or causing to be presented, for payment to, or approval by, federal programs, including Medicare and Medicaid, claims for
items or services, including drugs and biologics, that are false or fraudulent; |
| ● | Health Insurance Portability and Accountability Act of 1996
(“HIPAA”) created additional federal criminal statutes that prohibit among other actions, knowingly and willfully executing,
or attempting to execute, a scheme to defraud any healthcare benefit program, including private third-party payors or making any false,
fictitious or fraudulent statement in connection with the delivery of or payment for healthcare benefits, items or services; |
| ● | HIPAA, as amended by the Health Information Technology for
Economic and Clinical Health Act of 2009 and their implementing regulations, imposes obligations on certain covered healthcare providers,
health plans, and healthcare clearinghouses and their respective business associates and covered subcontractors types of individuals
and entities regarding the electronic exchange of information in common healthcare transactions, as well as standards relating to the
privacy and security of individually identifiable health information; |
| ● | The federal Physician Payments Sunshine Act requires certain manufacturers of drugs, devices,
biologics and medical supplies for which payment is available under Medicare, Medicaid or the Children’s Health Insurance
Program, with specific exceptions, to report annually to the Centers for Medicare and Medicaid Services (“CMS”), information related to
payments or other transfers of value made to physicians (defined to include doctors, dentists, optometrists, podiatrists and
chiropractors), physician assistants, nurse practitioners, clinical nurse specialists, anesthesiologist assistants, certified nurse
anesthetists and certified nurse-midwives and teaching hospitals, as well as ownership and investment interests held by physicians
and their immediate family members.; and |
| ● | The Foreign Corrupt Practices Act (“FCPA”) prohibits
U.S. businesses and their representatives from offering to pay, paying, promising to pay or authorizing the payment of money or
anything of value to a foreign official in order to influence any act or decision of the foreign official in his or her official capacity
or to secure any other improper advantage in order to obtain or retain business. |
Many states have similar
laws and regulations, such as anti-kickback and false claims laws, that may be broader in scope and may apply regardless of payor, in
addition to items and services reimbursed under Medicaid and other state programs. Additionally, we may be subject to state laws that
require pharmaceutical companies to comply with the federal government’s and/or pharmaceutical industry’s voluntary compliance
guidelines, state laws that require drug and biologics manufacturers to report information related to payments and other transfers of
value to physicians and other healthcare providers or marketing expenditures, as well as state and foreign laws governing the privacy
and security of health information, many of which differ from each other in significant ways and often are not preempted by HIPAA. Additionally,
to the extent that our product is sold in a foreign country, we may be subject to similar foreign laws.
Pharmaceutical Coverage, Pricing and Reimbursement
Significant uncertainty exists
as to the coverage and reimbursement status of any product candidates for which we obtain regulatory approval. In the United States
and markets in other countries, sales of any products for which we receive regulatory approval for commercial sale will depend, in part,
on the extent to which third-party payors provide coverage, and establish adequate reimbursement levels for such drug products. In the
United States, third-party payors include federal and state healthcare programs, government authorities, private managed care providers,
private health insurers and other organizations.
Third-party payors are increasingly
challenging the price, examining the medical necessity and reviewing the cost-effectiveness of medical drug products and medical services,
in addition to questioning their safety and efficacy. Such payors may limit coverage to specific drug products on an approved list, also
known as a formulary, which might not include all of the FDA-approved drugs for a particular indication. We may need to conduct expensive
pharmaco-economic studies in order to demonstrate the medical necessity and cost-effectiveness of our products, in addition to the costs
required to obtain the FDA approvals. Nonetheless, our product candidates may not be considered medically necessary or cost-effective.
Moreover, the process for determining whether a third-party payor will provide coverage for a drug product may be separate from the process
for setting the price of a drug product or for establishing the reimbursement rate that such a payor will pay for the drug product. A
payor’s decision to provide coverage for a drug product does not imply that an adequate reimbursement rate will be approved. Further,
one payor’s determination to provide coverage for a drug product does not assure that other payors will also provide coverage for
the drug product. Adequate third-party reimbursement may not be available to enable us to maintain price levels sufficient to realize
an appropriate return on our investment in product development.
The marketability of any
product candidates for which we receive regulatory approval for commercial sale may suffer if the government and third-party payors fail
to provide adequate coverage and reimbursement. In addition, emphasis on managed care in the United States has increased and could
increase the pressure on pharmaceutical pricing. Coverage policies and third-party reimbursement rates may change at any time. Even if
favorable coverage and reimbursement status is attained for one or more products for which we receive regulatory approval, less favorable
coverage policies and reimbursement rates may be implemented in the future.
Healthcare Reform
The United States and
many foreign jurisdictions have enacted or proposed legislative and regulatory changes affecting the healthcare system. The United States
government, state legislatures and foreign governments also have shown significant interest in implementing cost-containment programs
to limit the growth of government-paid healthcare costs, including price controls, restrictions on reimbursement, and requirements for
substitution of generic products for branded prescription drugs and biologics. In recent years, Congress has considered reductions
in Medicare reimbursement levels for drugs and biologics administered by physicians. CMS, the agency that administers the Medicare and
Medicaid programs, also has authority to revise reimbursement rates and to implement coverage restrictions for some drugs and biologics.
Cost reduction initiatives and changes in coverage implemented through legislation or regulation could decrease utilization of and reimbursement
for any approved products. While Medicare regulations apply only to drug benefits for Medicare beneficiaries, private payors often follow
Medicare coverage policy and payment limitations in setting their own reimbursement rates. Therefore, any reduction in reimbursement that
results from federal legislation or regulation may result in a similar reduction in payments from private payors.
The Affordable Care Act substantially changed
the way healthcare is financed by both governmental and private insurers, and significantly impacts the pharmaceutical industry. The Affordable
Care Act is intended to broaden access to health insurance, reduce or constrain the growth of healthcare spending, enhance remedies against
healthcare fraud and abuse, add new transparency requirements for healthcare and health insurance industries, impose new taxes and fees
on pharmaceutical and medical device manufacturers, and impose additional health policy reforms. Among other things, the Affordable Care
Act expanded manufacturers’ rebate liability under the Medicaid Drug Rebate Program by increasing the minimum Medicaid rebate for
both branded and generic drugs and biologics, expanded the 340B program, and revised the definition of average manufacturer price (“AMP”),
which could increase the amount of Medicaid drug rebates manufacturers are required to pay to states. The legislation also extended Medicaid
drug rebates, previously due only on fee-for-service Medicaid utilization, to include the utilization of Medicaid managed care organizations
as well and created an alternative rebate formula for certain new formulations of certain existing products that is intended to increase
the amount of rebates due on those drugs.
Other legislative changes
have been proposed and adopted since passage of the Affordable Care Act. The Budget Control Act of 2011, among other things,
included automatic reductions to several government programs, including aggregate reductions to Medicare payments to healthcare providers
of up to 2.0% per fiscal year, which went into effect in April 2013 and will remain in effect through 2031. The American Taxpayer
Relief Act was signed into law, which, among other things, reduced Medicare payments to several types of providers, including hospitals,
imaging centers and cancer treatment centers, and increased the statute of limitations period for the government to recover overpayments
to providers from three to five years.
There have been executive,
judicial and congressional challenges to the Affordable Care Act. We cannot predict what additional challenges to the Affordable Care
Act may arise in the future, the outcome thereof, or the impact any such actions may have on our business. Additionally, the Biden administration
has introduced various measures in recent years, focusing on healthcare and medical-product pricing, in particular. It remains to
be seen how these measures will affect our business and there is uncertainty as to what other healthcare programs and regulations may
be implemented or changed at the federal and/or state level in the U.S., but it is possible that such initiatives could have an adverse
effect on our ability to obtain FDA approval or clearance and/or successfully commercialize products in the U.S. in the future. For
example, any changes that reduce, or impede the ability of healthcare providers to obtain reimbursement for medical procedures in which
the products we currently, or intend to, commercialize are used, or that reduce medical procedure volumes, could adversely affect our
operations and/or future business plans. The financial impact of U.S. healthcare reform legislation over the next few years
will depend on a number of factors, including the policies reflected in implementing regulations and guidance and changes in sales volumes
for medical devices affected by the legislation. From time to time, legislation is drafted, introduced, and passed that could significantly
change the statutory provisions governing coverage, reimbursement, pricing, and marketing of medical device products. In addition, third-party
payor coverage and reimbursement policies are often revised or interpreted in ways that may significantly affect our business and our
products.
Further legislative and regulatory
changes under the Affordable Care Act remain possible, and it is unknown what form any such changes or any law would take, and how or
whether it may affect our business in the future. We expect that changes or additions to the Affordable Care Act, the Medicare and Medicaid
programs, changes allowing the federal government to directly negotiate drug prices, and changes stemming from other healthcare reform
measures, especially with regard to healthcare access, financing or other legislation in individual states, could have a material adverse
effect on the healthcare industry.
The Affordable Care Act requires
pharmaceutical manufacturers of branded prescription drugs and biologics to pay a branded prescription drug fee to the federal government.
Each individual pharmaceutical manufacturer pays a prorated share of the branded prescription drug fee, based on the dollar value of its
branded prescription drug sales to certain federal programs identified in the law. Furthermore, the law requires manufacturers to provide
a 50% discount (increased by subsequent legislation to a 70% discount) off the negotiated price of prescriptions filled by beneficiaries
in the Medicare Part D coverage gap, referred to as the “donut hole.” The Inflation Reduction Act of 2022 (“IR
Act”) includes several provisions that may impact our business to varying degrees. The IR Act also includes provisions that reduce
the out-of-pocket spending cap for Medicare Part D beneficiaries from $7,050 to $2,000 starting in 2025, thereby effectively eliminating
the donut hole. Pharmaceutical manufacturers will be required to provide a 10% discount of all biosimilar and brand name prescription
drugs covered under the Medicare Part D plan benefit during the initial coverage period before the beneficiary reaches the $2,000
out-of-pocket spending cap. Once the patient reaches the out-of-pocket spending cap, they enter catastrophic coverage and drug manufacture
liability for biosimilar and brand name drugs increases to 20%. Furthermore, the IR Act allows the U.S. government to negotiate Medicare
Part B and Part D price caps for certain high-cost drugs and biologics without generic or biosimilar competition; requires companies
to pay rebates to Medicare for certain drug prices that increase faster than inflation; and delays until January 1, 2032 the implementation
U.S. Department of Health and Human Service (“HHS”) rebate rule that would have limited the fees that pharmacy benefit
managers can charge.
The Affordable Care Act also
expanded the Public Health Service’s 340B drug pricing program, which requires participating manufacturers to agree to charge statutorily
defined covered entities no more than the 340B “ceiling price” for the manufacturer’s covered outpatient drugs. The
Affordable Care Act expanded the 340B program to include additional types of covered entities: certain freestanding cancer hospitals,
critical access hospitals, rural referral centers, and sole community hospitals, each as defined by the Affordable Care Act. Because the
340B ceiling price is determined based on AMP and Medicaid drug rebate data, revisions to the Medicaid rebate formula and AMP definition
could cause the required 340B discounts to increase.
The American Rescue Plan
Act of 2021 eliminated the statutory Medicaid drug rebate cap, previously set at 100% of a drug’s AMP, for single source
and innovator multiple source drugs, beginning January 1, 2024. Payment methodologies may be subject to changes in healthcare legislation
and regulatory initiatives as well. For example, CMS may develop new payment and delivery models, such as bundled payment models.
Recently, there has been
heightened governmental scrutiny over the manner in which manufacturers set prices for their marketed products. Such scrutiny has resulted
in several recent U.S. Congressional inquiries and proposed and enacted federal and state legislation designed to, among other things,
bring more transparency to drug pricing, review the relationship between pricing and manufacturer patient programs, reduce the cost of
drugs under Medicare, and reform government program reimbursement methodologies for pharmaceutical products.
At the state level, legislatures
have increasingly passed legislation and implemented regulations designed to control pharmaceutical product pricing, including price or
patient reimbursement constraints, discounts, restrictions on certain product access, and marketing cost disclosure and transparency measures,
and in some cases, designed to encourage importation from other countries and bulk purchasing.
We expect that additional
federal, state, and foreign healthcare reform measures will be adopted in the future, any of which could limit the amounts that federal
and state governments will pay for healthcare products and services, which could result in limited coverage and reimbursement and reduced
demand for our products, once approved, or additional pricing pressures.
Employees and Human Capital Resources
As of April 1, 2024, we had eight full-time employees and one part-time
employee. Of the nine total employees, two are focused on general and administrative functions and seven are conducting R&D. Our employees
are not represented by labor unions or covered by collective bargaining agreements and we consider our relationship with our employees
to be good.
Compensation and Benefits
Our employee-related objectives
include, as applicable, identifying, recruiting, retaining, and incentivizing our management team and our clinical, scientific and other
employees and consultants. The principal purposes of our equity and cash incentive plans are to attract, retain and motivate personnel
through the granting of stock-based and cash-based compensation awards, in order to align our interests and the interests of our stockholders
with those of our employees and consultants. In addition, all of our employees are eligible for health insurance, paid and unpaid leaves
including paid parental leave, a retirement plan, life and disability/accident coverage, and parking or commuter assistance and an employee
assistance.
Corporate Information
We were incorporated under
the laws of the state of Delaware on October 2, 2020 under the name Phoenix Biotech Acquisition Corporation, CERo was incorporated under
the laws of the state of Delaware on September 23, 2016. On February 14, 2024, we consummated a merger with Legacy CERo and subsequently
changed our name to “CERo Therapeutics Holdings, Inc.” Our corporate headquarters are currently located at 210 Haskins Way,
Suite 230, South San Francisco, California 94080, and our telephone number is (215) 731-9450. Our website is www.cero.bio. The
information on our website is not incorporated by reference in this Annual Report or in any other filings we make with the U.S.
Securities and Exchange Commission (“SEC”).
Available Information
Our internet address is www.cero.bio.
Our investor relations website is located at www.cero.bio/investors. We make available free of charge on our investor relations
website under “SEC Filings” our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K,
our directors’ and officers’ Section 16 reports and any amendments to those reports as soon as reasonably practicable after
filing or furnishing such materials to the SEC. They are also available for free on the SEC’s website at www.sec.gov.
We use our investor relations
website as a means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD.
Investors should monitor such website, in addition to following our press releases, SEC filings and public conference calls and webcasts.
Information relating to our corporate governance is also included on our investor relations website. The information in or accessible
through the SEC and our website are not incorporated into, and are not considered part of, this filing.
Item 1A. Risk Factors.
In evaluating our business, careful consideration
should be given to the following risk factors, in addition to the other information set forth in this Annual Report and in other documents
that we file with the SEC. An investment in our securities involves a high degree
of risk. You should carefully consider the risks described below before making an investment decision. Our business, prospects, financial
condition or operating results could be harmed by any of these risks, as well as other risks not currently known to us or that we currently
consider immaterial. The trading price of our securities could decline due to any of these risks, and, as a result, you may lose all or
part of your investment. Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also impair
our business operations. This Annual Report also contains forward-looking statements that involve risks and uncertainties. Our actual
results could differ materially from those anticipated in the forward-looking statements as a result of a number of factors, including
the risks described below. Certain statements in this “Risk Factors” section are forward-looking statements. See “Cautionary
Note Regarding Forward-Looking Statements.”
Risks Related to our Business and Industry
We have incurred significant losses in every
year since our inception. We expect to continue to incur losses over the next several years and may never achieve or maintain profitability.
We are a preclinical stage
biopharmaceutical company with a limited operating history, and we have incurred significant net losses since our inception in 2016. We
incurred net losses of approximately $7.5 million and $11.8 million for the years ended December 31, 2023 and 2022, respectively.
As of December 31, 2023, we had an accumulated deficit of $42.2 million. We have funded our operations to date primarily with proceeds
from the sale of our equity securities in private financing transactions.
We have no products approved
for commercial sale and we are devoting, and expect to continue devoting, substantially all of our financial resources and efforts to
R&D of our only programmed CER-T cell product candidate, CER-1236, as well as to building out our manufacturing infrastructure,
CDMO relationships and CER-T cell programming technologies. Investment in biopharmaceutical product development, especially preclinical
products, is highly speculative because it entails substantial upfront capital expenditures and significant risk that any potential product
candidate will not successfully undergo or complete necessary clinical trials, fail to demonstrate adequate effect or an acceptable safety
profile, gain regulatory approval and become commercially viable.
We expect that it could take
several years until any of our product candidates, which at present is solely CER-1236, receive regulatory and marketing approval
and are commercialized, and we may never be successful in obtaining regulatory and marketing approval and commercializing product candidates.
We expect to continue to incur significant expenses and increasing operating losses for the foreseeable future. These net losses will
adversely impact our stockholders’ equity and net assets and may fluctuate significantly from quarter to quarter and year to year.
We anticipate that our expenses will increase substantially as we:
| ● | continue our ongoing and planned R&D
activities for our CER-T cell therapies and product candidates; |
| ● | pursue preclinical studies and initiate clinical trials for
our CER-T cell therapies and other product candidates; |
| ● | seek to discover and develop additional product candidates
and further expand our product pipeline; |
| ● | seek regulatory and marketing approvals for any product candidates
that successfully complete clinical trials; |
| ● | establish sales, marketing and distribution infrastructure
to commercialize any product candidate for which we may obtain regulatory approval; |
| ● | develop and refine the manufacturing process for our product
candidates; |
| ● | change or add additional manufacturers or suppliers of biological
materials or product candidates; |
| ● | establish or supplement relationships with CDMOs, CROs and
other third party collaborators; |
| ● | develop, maintain, expand and protect our intellectual property
portfolio; |
| ● | acquire or in-license other product candidates and technologies; |
| ● | hire clinical, quality control and manufacturing personnel; |
| ● | add clinical, operational, financial and management information
systems and personnel, including personnel to support our product development and planned future commercialization efforts; and |
| ● | incur additional legal, accounting and other expenses associated
with operating as a public company. |
To become and remain profitable,
we must succeed in developing and eventually commercializing products that generate significant revenue. This will require us to be successful
in a range of challenging activities, including completing preclinical studies and clinical trials for our product candidates, preparing
a satisfactory filing package for regulatory authorities, obtaining regulatory approval, manufacturing, marketing and selling any products
for which we may obtain regulatory approval, as well as discovering and developing additional product candidates. We may never succeed
in these activities and, even if we do, may never generate revenues that are significant enough to achieve profitability.
Because of the numerous risks
and uncertainties associated with the development, manufacturing, delivery and commercialization of complex autologous cell therapies,
we are unable to accurately predict the timing or amount of expenses or when, or if, we will be able to achieve profitability. If we are
required by regulatory authorities to perform studies in addition to those currently expected, or if there are any delays in the initiation
and completion of our clinical trials or the development of any of our product candidates, our expenses could increase and profitability
could be further delayed.
Even if we achieve
profitability, we may not be able to sustain or increase profitability on a quarterly or annual basis. Our failure to become and
remain profitable would depress the value of our securities and could impair our ability to raise capital, expand our business,
maintain our R&D efforts or continue our operations. A decline in the value of our securities could also cause you to lose all
or part of your investment.
Our independent registered public accountants
have expressed substantial doubt as to our ability to continue as a going concern.
In its report on our financial
statements for the year ended December 31, 2023, our independent registered public accounting firm included an explanatory paragraph that
expressed substantial doubt about our ability to continue as a going concern. Our current cash level raises substantial doubt about our
ability to continue as a going concern. In addition, our future financial statements may include similar qualifications about our ability
to continue as a going concern. Our financial statements were prepared assuming that we will continue as a going concern and do not include
any adjustments that may result from the outcome of this uncertainty. If we are unable to meet our current operating costs, we will need
to seek additional financing or modify or cease our operational plans. If we seek additional financing to fund our business activities
in the future and there remains substantial doubt about our ability to continue as a going concern, investors or other financing sources
may be unwilling to provide additional funding to us on commercially reasonable terms or at all.
Our limited operating history makes it difficult
to evaluate our business and assess our future viability and prospects.
We are a preclinical stage
company with a limited operating history. We commenced operations in 2016, and our operations to date have been limited to organizing
and planning our development efforts, raising capital, conducting discovery and research activities, filing patent applications, identifying
potential product candidates, undertaking preclinical studies, and establishing arrangements with third parties for the manufacture of
initial quantities of CER-1236 and component materials. We have not yet demonstrated our ability to successfully complete any clinical
trials, obtain regulatory approvals, manufacture a commercial-scale product or arrange for a third party to do so on our behalf, or conduct
sales, marketing and distribution activities necessary for successful product commercialization. Consequently, any predictions you make
about our future success or viability may not be as accurate as they could be if we had a longer operating history.
In addition, as a young business,
we may encounter unforeseen expenses, difficulties, complications, delays and other known and unknown factors. We will need to transition
at some point from a company with a R&D focus to a company capable of supporting commercial activities. We may not
be successful in such a transition.
We expect our financial condition
and operating results to continue to fluctuate significantly from quarter to quarter and year to year due to a variety of factors, many
of which are beyond our control. Accordingly, you should not rely upon the results of any quarterly or annual periods as indications of
future operating performance.
Our business is highly dependent on the
success of our lead product candidate. If we are unable to advance clinical development, obtain approval of and successfully commercialize
our lead product candidate for the treatment of patients in approved indications, our business would be significantly harmed.
Our business and future success
depends on our ability to advance clinical development, obtain regulatory approval of, and then successfully commercialize, CER-1236,
our lead product candidate. Because our CER-1236 product candidate will be among the first autologous T cell product candidates engineered
with cytotoxic and phagocytic potency to be evaluated in clinical trials, the failure of such product candidate, or the failure of other
autologous T cell therapies, including for reasons due to safety, efficacy or durability, may impede our ability to develop our product
candidates, and significantly influence physicians’ and regulators’ opinions with regard to the viability of our entire pipeline
of autologous T cell therapies.
All of our product candidates,
including our lead product candidate, will require additional preclinical, clinical and non-clinical development, regulatory review and
approval in multiple jurisdictions, substantial investment, access to sufficient commercial manufacturing capacity and significant marketing
efforts before we can generate any revenue from product sales. In addition, because our other product candidates are based on similar
technology as our lead product candidate, if the lead product candidate encounters additional safety issues, efficacy problems, manufacturing
problems, developmental delays, regulatory issues or other problems, our development plans and business would be significantly harmed.
We have not generated any revenue and may
never be profitable.
Our ability to become profitable
depends upon our ability to generate revenue. To date, we have not generated any revenue. We do not expect to generate significant revenue
unless or until we successfully complete clinical development and obtain regulatory approval of, and then successfully commercialize,
our product candidates. We do not know when, or if, we will generate any revenue. All of our product candidates, including CER-1236, are
in the preclinical stages of development and will require additional preclinical studies, clinical development regulatory review and approval,
substantial investment, access to sufficient commercial manufacturing capacity and significant marketing efforts before we can generate
any revenue from product sales. Our ability to generate revenue depends on a number of factors, including, but not limited to, our ability
to:
| ● | successfully complete preclinical studies and clinical trials
for our CER-T cell product candidates; |
| ● | timely file and receive acceptance of INDs, and amendments
thereto, as applicable, in order to commence our planned and future clinical trials; |
| ● | successfully enroll subjects in, and complete, clinical trials
for our CER-T cell product candidates; |
| ● | hire additional staff, including clinical, scientific and
management personnel; |
| ● | timely file BLAs and receive regulatory approvals for our
product candidates from the FDA and other regulatory authorities; |
| ● | initiate and successfully complete clinical trials and safety
studies required to obtain U.S. and applicable foreign marketing approval for our product candidates; |
| ● | establish commercial manufacturing capabilities through third-party
manufacturers and CDMOs for clinical supply and commercial manufacturing of our product candidates; |
| ● | obtain and maintain patent and trade secret protection or
regulatory exclusivity for our product candidates; |
| ● | launch commercial sales of our product candidates, if and
when approved, whether alone or in collaboration with others; |
| ● | maintain a continued acceptable safety profile of the product
candidates following approval; |
| ● | obtain and maintain acceptance of the product candidates,
if and when approved, by patients, the medical community and third-party payors; |
| ● | position our products to effectively compete with other therapies; |
| ● | obtain and maintain favorable coverage and adequate reimbursement
by third-party payors for our product candidates; and |
| ● | enforce and defend intellectual property rights and claims
with respect to our product candidates. |
Many of the factors listed
above are beyond our control and could cause us to experience significant delays or prevent us from obtaining regulatory approvals or
commercialize our product candidates. Even if we are able to commercialize our product candidates, we may not achieve profitability soon
after generating product sales, if ever. If we are unable to generate sufficient revenue through the sale of our product candidates or
any future product candidates, we may be unable to continue operations without continued funding.
Our engineered CER-T cells represent a novel
approach to cancer treatment that creates significant challenges for us.
We are developing autologous
T-cell product candidates that are engineered from healthy donor T-cells to express chimeric engulfment receptors (“CERs”)
and are intended for use in patients with certain cancers. Advancing these novel product candidates creates significant challenges for
us, including:
| ● | manufacturing our product candidates to our or regulatory
specifications and in a timely manner to support our clinical trials, and, if approved, commercialization; |
| ● | sourcing clinical and, if approved, commercial supplies for
the raw materials used to manufacture our product candidates; |
| ● | understanding and addressing variability in the quality of
a donor’s T cells, which could ultimately affect our ability to produce product in a reliable and consistent manner and treat certain
patients; |
| ● | educating medical personnel regarding the potential side
effect profile of our product candidates, if approved, such as the potential adverse side effects related to CRS, neurotoxicity, prolonged
cytopenia, coagulation abnormalities, thrombosis, hypotension, aplastic anemia and neutropenic sepsis; |
| ● | using medicines to preempt or manage adverse side effects
of our product candidates and such medicines may be difficult to source or costly or may not adequately control the side effects or may
have other safety risks or a detrimental impact on the efficacy of the treatment; |
| ● | conditioning patients with cyclophosphamide, fludarabine,
or bendamustine in advance of administering our product candidates, which may be difficult to source, costly or increase the risk of
infections and other adverse side effects; |
| ● | obtaining regulatory approval, as the FDA and other regulatory
authorities have limited experience with development of CER T cell therapies for cancer; |
| ● | establishing sales and marketing capabilities upon obtaining
any regulatory approval to gain market acceptance of a novel therapy; and |
| ● | obtaining acceptance and approval by physicians, patients,
hospitals, cancer treatment centers and others in the medical community. |
Our preclinical programs may experience
delays or may never advance to clinical trials, which would adversely affect our ability to obtain regulatory approvals or to commercialize
these programs on a timely basis or at all, which would have an adverse effect on our business.
Our product candidates, including
CER-1236, are in the preclinical development stage. The risk of failure of preclinical programs is high. Before we can commence clinical
trials for a product candidate, we are nearing completion of extensive preclinical testing and studies to obtain regulatory clearance
to initiate human clinical trials with CER-1236, and have engaged in a pre-IND meeting with the FDA. We expect that our clinical
trials will be conducted on populations based in the United States and Europe. We cannot be certain of the timely completion or outcome
of our preclinical testing and studies and cannot predict if the FDA, the EMA or other regulatory authorities will accept our proposed
clinical programs or if the outcome of our preclinical testing and studies will ultimately support the further development of our programs.
As a result, we cannot be sure that we will be able to submit INDs or similar applications for our clinical programs on the timelines
we expect, if at all.
Success in preclinical studies or clinical
trials may not be indicative of results in future clinical trials.
Results from preclinical
studies are not necessarily predictive of future clinical trial results, and interim results of a clinical trial are not necessarily indicative
of final results. Our product candidates may ultimately fail to show the desired safety and efficacy in clinical settings despite positive
results in preclinical studies or having successfully advanced through initial clinical trials. This failure to establish sufficient efficacy
and safety could cause us to abandon clinical development of our product candidates.
Manufacturing genetically engineered products
is complex and we, or our third-party manufacturers, may encounter difficulties in production. If we or any of our third-party manufacturers
encounter such difficulties, our ability to provide supply of our product candidates for clinical trials or our products for patients,
if approved, could be delayed or prevented.
Manufacturing genetically
engineered products is complex and may require the use of innovative technologies to handle living cells. Manufacturing these products
requires facilities specifically designed for and validated for this purpose and sophisticated quality assurance and quality control procedures
are necessary. Slight deviations anywhere in the manufacturing process, including filling, labeling, packaging, storage and shipping and
quality control and testing, may result in failures, product recalls or spoilage. When changes are made to the manufacturing process,
we may be required to provide preclinical and clinical data showing the comparable identity, strength, quality, purity or potency of the
products before and after such changes. If microbial, viral or other contaminations are discovered at manufacturing facilities, such facilities
may need to be closed for an extended period of time to investigate and remedy the contamination, which could delay clinical trials and
adversely harm our business. The use of biologically derived ingredients can also lead to allegations of harm, including infections or
allergic reactions, or closure of product facilities due to possible contamination.
In addition, there are risks
associated with large scale manufacturing for clinical trials or commercial scale including, among others, cost overruns, potential problems
with process scale-up, process reproducibility, stability issues, compliance with good manufacturing practices, lot consistency and timely
availability of raw materials. Even if we obtain marketing approval for any of our product candidates, there is no assurance that we or
our manufacturers will be able to manufacture the approved product to specifications acceptable to the FDA, the EMA or other comparable
foreign regulatory authorities, to produce it in sufficient quantities to meet the requirements for the potential commercial launch of
the product or to meet potential future demand. If we or our manufacturers are unable to produce sufficient quantities for clinical trials
or for commercialization, our development and commercialization efforts would be impaired, which would have an adverse effect on our business,
financial condition, results of operations and growth prospects.
Genetic engineering of T cells to create
CER-T cells is a relatively new technology, and if we are unable to use this technology in our intended product candidates, our revenue
opportunities will be materially limited.
Our technology involves a
relatively new approach to T cell gene therapy. This technology may also not be shown to be effective in clinical studies that we may
conduct, or may be associated with safety issues that may negatively affect the development of our product candidates. For instance, lentiviral
gene transduction may create unintended changes to the DNA such as a non-target site gene insertion, a large deletion, or a DNA translocation,
any of which could lead to oncogenesis.
We may not be successful in our efforts
to identify or discover additional product candidates.
The success of our business
depends primarily upon our ability to identify, develop and commercialize products based on our CER-T cell technology. Our research programs
may fail to identify other potential product candidates outside of CER-1236 for clinical development for a number of reasons. We may be
unsuccessful in identifying potential product candidates or our potential product candidates may be shown to have harmful side effects
or may have other characteristics that may make the products unmarketable or unlikely to receive marketing approval. Research programs
to identify new product candidates require substantial technical, financial and human resources. We may focus our efforts and resources
on potential programs or product candidates that ultimately prove to be unsuccessful. If any of these events occur, we may be forced to
abandon our research, development or commercialization efforts for a program or programs, which would have a material adverse effect on
our business and could potentially cause us to cease operations.
Even if we obtain regulatory approval of
a product candidate, the product may not gain market acceptance among physicians, patients, hospitals, cancer treatment centers and others
in the medical community.
The use of engineered T cells
as a potential cancer treatment is nascent and may not become broadly accepted by physicians, patients, hospitals, cancer treatment centers
and others in the medical community. We expect physicians with expertise in immunotherapy to be particularly important to the market acceptance
of our products and we may not be able to educate them on the benefits of using our product candidates for many reasons. For example,
certain of the product candidates that we will be developing may result in unacceptable and unanticipated side effects, including death.
Additional factors will influence whether our product candidates are accepted in the market, including:
| ● | the clinical indications for which our product candidates
are approved; |
| ● | physicians, hospitals, cancer treatment centers and patients
considering our product candidates as a safe and effective treatment; |
| ● | the potential and perceived advantages of our product candidates
over alternative treatments; |
| ● | the prevalence and severity of any side effects; |
| ● | product labeling or product insert requirements of the FDA
or other regulatory authorities; |
| ● | limitations or warnings contained in the labeling approved
by the FDA or other regulatory authorities; |
| ● | the timing of market introduction of our product candidates
as well as competitive products; |
| ● | the cost of treatment in relation to alternative treatments; |
| ● | the availability of coverage and adequate reimbursement by
third-party payors and government authorities; |
| ● | the willingness of patients to pay out-of-pocket in the absence
of coverage and adequate reimbursement by third-party payors and government authorities; |
| ● | relative convenience and ease of administration, including
as compared to alternative treatments and competitive therapies; and |
| ● | the effectiveness of our sales and marketing efforts. |
If our product candidates
are approved but fail to achieve market acceptance among physicians, patients, hospitals, cancer treatment centers or others in the medical
community, we will not be able to generate significant revenue. Even if our products achieve market acceptance, we may not be able to
maintain that market acceptance over time if new products or technologies are introduced that are more favorably received than our products,
are more cost effective or render our products obsolete.
Data from our preclinical studies is limited
and may change as patient data become available or may not be validated in any future or advanced clinical trial.
Data from preclinical studies
and any clinical trials that we may complete is subject to the risk that one or more of the clinical outcomes may materially change as
patient enrollment continues and more patient data becomes available. For example, preclinical and Phase 1 results are preliminary
in nature and should not be viewed as predictive of ultimate success. It is possible that such results will not continue or may not be
repeated in any clinical trial of our product candidates. For instance, our preclinical studies provide limited data and any clinical
trials may not validate such results. Additionally, manufacturing can impact clinical outcomes and we have not yet completed manufacturing
runs with a CDMO. We may also fail to develop and transfer to a CDMO any optimized manufacturing processes for any of our programs.
Ultimately, if we cannot manufacture our product candidates with consistent and reproducible product characteristics, our ability to develop
and commercialize any product candidate would be significantly impacted.
Preliminary data also remains
subject to audit and verification procedures that may result in the final data being materially different from the preliminary data we
previously published. As a result, initial, interim and preliminary data should be viewed with caution until the final data are available.
Adverse differences between preliminary or interim data and final data could significantly harm our business prospects.
We may not be able to file INDs or IND amendments
to commence clinical trials on the timelines we expect, and even if we are able to, the FDA may not permit us to proceed.
We may not be able to file
INDs, including the IND for CER-1236, on the timelines we expect. For example, we may experience manufacturing delays or other delays
with IND-enabling studies. Moreover, we cannot be sure that submission of an IND will result in the FDA allowing clinical trials to begin,
or that, once begun, issues will not arise that suspend or terminate clinical trials. Additionally, even if such regulatory authorities
agree with the design and implementation of the clinical trials set forth in an IND, we cannot guarantee that such regulatory authorities
will not change their requirements in the future. These considerations also apply to new clinical trials we may submit as amendments to
existing INDs.
Clinical trials are difficult to design
and implement, involve uncertain outcomes and may not be successful.
Human clinical trials are
difficult to design and implement, in part because they are subject to rigorous regulatory requirements. The design of a clinical trial
can determine whether its results will support approval of a product, and flaws in the design of a clinical trial may not become apparent
until the clinical trial is well advanced. We may be unable to design and execute a clinical trial that will be successful to achieve
regulatory approval. There is a high failure rate for biological products proceeding through clinical trials, which may be higher for
our product candidates because they are based on new technology and engineered on a patient-by-patient basis. Many companies in the pharmaceutical
and biotechnology industries have suffered significant setbacks in late-stage clinical trials even after achieving promising results in
preclinical testing and earlier-stage clinical trials. Data obtained from preclinical and clinical activities are subject to varying interpretations,
which may delay, limit or prevent regulatory approval. In addition, we may experience regulatory delays or rejections as a result of many
factors, including changes in regulatory policy during the period of our product candidate development. Any such delays could negatively
impact our business, financial condition, results of operations and prospects.
We will depend on enrollment of patients
in our clinical trials for our product candidates. If we encounter difficulties enrolling patients in our clinical trials, our clinical
development activities could be delayed or otherwise adversely affected.
Identifying and qualifying
patients to participate in clinical trials of our product candidates will be critical to our success. We may experience difficulties in
patient enrollment in our clinical trials for a variety of reasons. The timely completion of clinical trials in accordance with their
protocols depends, among other things, on our ability to enroll a sufficient number of patients who remain in the study until its conclusion.
The enrollment of patients depends on many factors, including:
| ● | the patient eligibility criteria defined in the protocol; |
| ● | the number of patients with the disease or condition being
studied; |
| ● | the perceived risks and benefits of the product candidate
in the trial; |
| ● | clinicians’ and patients’ perceptions as to the
potential advantages of the product candidate being studied in relation to other available therapies, including any new drugs that may
be approved for the indications we are investigating or drugs that may be used off-label for these indications; |
| ● | the size and nature of the patient population required for
analysis of the trial’s primary and secondary endpoints; |
| ● | the proximity of patients to study sites; |
| ● | the design of the clinical trial; |
| ● | our ability to recruit clinical trial investigators with
the appropriate competencies and experience; |
| ● | competing clinical trials for similar therapies or other
new therapeutics not involving T cell-based immunotherapy; |
| ● | our ability to obtain and maintain patient consents; |
| ● | the risk that patients enrolled in clinical trials will drop
out of the clinical trials before completion of their treatment; and |
| ● | other public health factors, including the coronavirus pandemic
or outbreaks of other infections. |
In particular, some of our clinical trials will look to enroll patients
with characteristics which are found in a very small population. For example, our clinical trial for CER-1236 will seek to enroll patients
with hematologic malignancies, including AML, MCL, CLL, and other B cell and myeloid neoplasms. Other companies are conducting clinical
trials with their engineered T cell therapies in hematologic malignancies and seek to enroll patients in their studies that may otherwise
be eligible for our clinical trials, which could lead to slow recruitment and delays in our clinical trials. In addition, since the number
of qualified clinical investigators is limited, we expect to conduct some of our clinical trials at the same clinical trial sites that
some of our competitors use, which could further reduce the number of patients who are available for our clinical trials in these clinical
trial sites.
Moreover, because our product
candidates represent a departure from more commonly used methods for cancer treatment, potential study participants and their doctors
may be inclined to use conventional therapies, such as chemotherapy and antibody therapy, rather than participate in our clinical trials.
Delays in patient enrollment
may result in increased costs or may affect the timing or outcome of the planned clinical trials, which could prevent completion of these
clinical trials and adversely affect our ability to advance the development of our product candidates. In addition, many of the factors
that may lead to a delay in the commencement or completion of clinical trials may also ultimately lead to the denial of regulatory approval
of our product candidates.
If the market opportunities for any of our
product candidates are smaller than we believe they are, our revenue may be adversely affected, and our business may suffer.
We are focused initially
on the development of treatments for cancers such as AML, MCL and CLL, and plan to eventually extend our treatments to other forms of
cancer. Our internal projections of addressable patient populations that have the potential to benefit from treatment with our product
candidates are based on estimates. If any of our estimates are inaccurate, the market opportunities for any of our product candidates
could be significantly diminished and have an adverse material impact on our business.
We currently have no marketing and sales
organization and have no experience in marketing products. If we are unable to establish marketing and sales capabilities or enter into
agreements with third parties to market and sell our product candidates, if licensed, we may not be able to generate product revenue.
We currently have no sales,
marketing or distribution capabilities and have no experience in marketing products. We intend to develop an in-house marketing organization
and sales force, which will require significant capital expenditures, management resources and time. We will have to compete with other
pharmaceutical and biotechnology companies to recruit, hire, train and retain marketing and sales personnel.
If we are unable or decide
not to establish internal sales, marketing and distribution capabilities, we will pursue collaborative arrangements regarding the sales
and marketing of our product candidates following their approval. However, there can be no assurance that we will be able to establish
or maintain such collaborative arrangements, or if we are able to do so, that they will have effective sales forces. Any revenue we receive
will depend upon the efforts of such third parties, which may not be successful. We may have little or no control over the marketing and
sales efforts of such third parties and our revenue from product sales may be lower than if we had commercialized our product candidates
ourselves. We also face competition in our search for third parties to assist us with the sales and marketing efforts of our product candidates.
There can be no assurance
that we will be able to develop in-house sales and distribution capabilities or establish or maintain relationships with third-party collaborators
to commercialize any product in the United States or overseas.
We face competition from companies that
have developed or may develop product candidates for the treatment of the diseases that we may target, including companies developing
novel therapies and platform technologies. If these companies develop platform technologies or product candidates more rapidly than we
do, if their platform technologies or product candidates are more effective or have fewer side effects, our ability to develop and successfully
commercialize product candidates may be adversely affected.
The development and commercialization
of cell and gene therapies is highly competitive. We compete with a variety of large pharmaceutical companies, multinational biopharmaceutical
companies, other biopharmaceutical companies and specialized biotechnology companies, as well as technology and/or therapeutics being
developed at universities and other research institutions. Our competitors are often larger and better funded than we are. Our competitors
have developed, are developing or will develop product candidates and processes competitive with ours. Competitive therapeutic treatments
include those that have already been approved and accepted by the medical community and any new treatments that are currently in development
or that enter the market. We believe that a significant number of product candidates are currently under development, and may become commercially
available in the future, for the treatment of conditions for which we may try to develop product candidates. There is intense and rapidly
evolving competition in the biotechnology and biopharmaceutical fields. We believe that while our T-cell based platform, its associated
intellectual property portfolio, the characteristics of our current and potential future product candidates and our scientific and technical
know-how together give us a competitive advantage in this space, competition from many sources remains.
Many of our competitors have
significantly greater financial, technical, manufacturing, marketing, sales and supply resources or experience than we do. If we successfully
obtain approval for any product candidate, we will face competition based on many different factors, including the safety and effectiveness
of our product candidates, the ease with which our product candidates can be administered, the timing and scope of regulatory approvals
for these product candidates, the availability and cost of manufacturing, marketing and sales capabilities, price, reimbursement coverage
and patent position. Competing products and product candidates could present superior treatment alternatives, including by being more
effective, safer, less expensive or marketed and sold more effectively than any products we may develop. Competitive products and product
candidates may make any product we develop obsolete or noncompetitive before we recover the expense of developing and commercializing
such product. Such competitors could also recruit our employees, which could negatively impact our level of expertise and our ability
to execute our business plan.
These competitors also compete
with us in recruiting and retaining qualified scientific and management personnel and establishing clinical study sites and patient registration
for clinical studies, as well as in acquiring technologies complementary to, or necessary for, our programs. Smaller or early-stage companies
may also prove to be significant competitors, particularly through collaborative arrangements with large and established companies.
Our commercial opportunity
could be reduced or eliminated if our competitors develop and commercialize products that are safer, more effective, have fewer or less
severe side effects, are more convenient or are less expensive or better reimbursed than any products that we may commercialize. Our competitors
also may obtain FDA, EMA or other regulatory approval for their products more rapidly than we may obtain approval for ours, which could
result in our competitors establishing a strong market position for either the product or a specific indication before we are able to
enter the market.
We are highly dependent on our key personnel,
including individuals with expertise in cell therapy development and manufacturing, and if we are not successful in attracting and retaining
highly qualified personnel, we may not be able to successfully implement our business strategy.
Our ability to compete in
the highly competitive biotechnology and pharmaceutical industries depends upon our ability to attract and retain highly qualified managerial,
scientific and medical personnel. We are highly dependent on the expertise of our management, scientific and medical personnel, including
our chief executive officer (“Chief Executive Officer”), Brian G. Atwood, our chief technical officer, Daniel Corey, and the
head of our scientific advisory board (the “Scientific Advisory Board”), Lawrence Corey. The loss of the services of any of
our executive officers, other key employees, and other scientific and medical advisors, and our inability to find suitable replacements
could result in delays in product development and harm our business.
We conduct substantially
all of our operations at our facilities in the South San Francisco area. The San Francisco Bay Area region is headquarters to many other
biopharmaceutical companies and many academic and research institutions. Competition for skilled personnel in our market is intense and
may limit our ability to hire and retain highly qualified personnel on acceptable terms or at all. Attrition may lead to higher costs
for hiring and retention, diversion of management time to address retention matters and disrupt the business.
To induce valuable employees
to remain at our company, in addition to salary and cash incentives, we have provided equity-based compensation for retention purposes.
Despite our efforts to retain valuable employees, members of our management, scientific and development teams may terminate their employment
with us on short notice. Although we have employment agreements with our key employees, these employment agreements provide for at-will
employment, which means that any of our employees could leave our employment at any time, with or without notice. We do not maintain “key
person” insurance policies on the lives of these individuals or the lives of any of our other employees. Our success also depends
on our ability to continue to attract, retain and motivate highly skilled junior, mid-level and senior managers as well as junior, mid-level
and senior scientific and medical personnel.
We will need to continue to grow the size
of our organization, and we may experience difficulties in managing this growth.
As our development, manufacturing
and commercialization plans and strategies develop, we expect to add managerial, operational, sales, R&D, marketing,
financial and other personnel. Current and future growth imposes and will impose significant added responsibilities on members of management,
including:
| ● | identifying, recruiting, integrating, maintaining and motivating
additional employees; |
| ● | managing our internal development efforts effectively, including
the clinical and FDA review process for our product candidates, while complying with our contractual obligations to contractors and other
third parties; and |
| ● | improving our operational, financial and management controls,
reporting systems and procedures. |
Our future financial performance
and our ability to commercialize our product candidates will depend, in part, on our ability to effectively manage our growth, and our
management may also have to divert a disproportionate amount of its attention away from day-to-day activities in order to devote
a substantial amount of time to managing these growth activities.
We currently rely, and for
the foreseeable future will continue to rely, in substantial part on certain independent organizations, advisors and consultants. There
can be no assurance that the services of independent organizations, advisors and consultants will continue to be available to us on a
timely basis when needed, or that we can find qualified replacements. We may also be subject to penalties or other liabilities if we mis-classify
employees as consultants. In addition, if we are unable to effectively manage our outsourced activities or if the quality or accuracy
of the services provided by consultants is compromised for any reason, our clinical trials may be extended, delayed or terminated, and
we may not be able to obtain regulatory approval of our product candidates or otherwise advance our business. There can be no assurance
that we will be able to manage our existing consultants or find other competent outside contractors and consultants on economically reasonable
terms, or at all.
If we are not able to effectively
expand our organization by hiring and retaining employees and expanding our groups of consultants and contractors, we may not be able
to successfully implement the tasks necessary to further develop, manufacture and commercialize our product candidates and, accordingly,
may not achieve our research, development, manufacturing and commercialization goals. Conversely, if we expand ahead of our business progress,
we may take on unnecessary costs.
We may form or seek strategic alliances
or enter into licensing arrangements in the future, and we may not realize the benefits of such alliances or licensing arrangements.
We may form or seek strategic
alliances, create joint ventures or collaborations or enter into licensing arrangements with third parties that we believe will complement
or augment our development and commercialization efforts with respect to our product candidates and any future product candidates that
we may develop. Any of these relationships may require us to incur non-recurring and other charges, increase our near and long-term expenditures,
issue securities that dilute our existing stockholders or disrupt our management and business. In addition, we face significant competition
in seeking appropriate strategic partners and the negotiation process is time-consuming and complex. Moreover, we may not be successful
in our efforts to establish a strategic partnership or other alternative arrangements for our product candidates because they may be deemed
to be at too early of a stage of development for collaborative effort and third parties may not view our product candidates as having
the requisite potential to demonstrate safety and efficacy. Any delays in entering into strategic partnership agreements related to our
product candidates could delay the development and commercialization of our product candidates in certain geographies for certain indications,
which would harm our business prospects, financial condition and results of operations.
If we license products or
new technologies or acquire businesses, we may not be able to realize the benefit of such transactions if we are unable to successfully
integrate them with our existing operations and company culture. For instance, certain of our agreements may require significant R&D that may not result in the development and commercialization of product candidates. We cannot be certain that, following
a strategic transaction or license, we will achieve the results, revenue or specific net income that justifies such transaction.
We will need substantial additional financing
to develop our product candidates and implement our operating plans, which financing we may be unable to obtain, or unable to obtain on
acceptable terms. If we fail to obtain additional financing, we may be unable to complete the development and commercialization of our
product candidates.
We expect to spend a substantial
amount of capital in the development and manufacturing of our product candidates, and we will need substantial additional financing to
do so. In particular, we will require substantial additional financing to enable commercial production of our product candidates and initiate
and complete registrational trials for multiple products in multiple regions. Further, if approved, we will require significant additional
capital in order to launch and commercialize our product candidates.
As of March 20, 2024, we
had $4.7 million in cash and cash equivalents. Changing circumstances may cause us to consume capital significantly faster than we
currently anticipate, and we may need to spend more money than currently expected because of circumstances beyond our control. We may
also need to raise additional capital sooner than we currently anticipate if we choose to expand more rapidly than we presently plan.
In any event, we will require additional capital for the further development and commercialization of our product candidates, including
funding our internal manufacturing capabilities.
We cannot be certain that
additional funding will be available on acceptable terms, or at all. We have no committed source of additional capital. If we are unable
to raise additional capital in sufficient amounts or on terms acceptable to us, we may have to significantly delay, scale back or discontinue
the development or commercialization of our product candidates or other R&D initiatives. We could be required to
seek collaborators for our product candidates at an earlier stage than otherwise would be desirable or on terms that are less favorable
than might otherwise be available or relinquish or license on unfavorable terms our rights to our product candidates in markets where
we otherwise would seek to pursue development or commercialization ourselves.
Any of the above events could
significantly harm our business, prospects, financial condition and results of operations and cause the price of our Common Stock to decline.
Raising additional capital may cause dilution
to our stockholders, restrict our operations or require us to relinquish rights to our product candidates.
Until such time, if ever,
as we can generate substantial revenue from the sale of our product candidates, we will need substantial additional financing to develop
our product candidates and implement our operating plans. To the extent that we raise additional capital through the sale of equity or
convertible debt securities, your ownership interest will be diluted, and the terms of these securities may include liquidation or other
preferences that could adversely affect your rights as a common stockholder. Debt financing and preferred equity financing, if available,
may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional
debt, making capital expenditures or declaring dividends.
If we raise additional funds
through collaborations, strategic alliances or marketing, distribution or licensing arrangements with third parties, we may be required
to relinquish valuable rights to our research programs or product candidates or grant licenses on terms that may not be favorable to us
or that may be at less than the full potential value of such rights. If we are unable to raise additional funds through equity or debt
financings or other arrangements with third parties when needed, we may be required to delay, limit, reduce or terminate our drug development
or future commercialization efforts or grant rights to third parties to develop and market product candidates that we would otherwise
prefer to develop and market ourselves.
If our security measures, or those of our
CROs, CDMOs, collaborators, contractors, consultants or other third parties upon whom we rely, are compromised or the security, confidentiality,
integrity or availability of our information technology, software, services, networks, communications or data is compromised, limited
or fails, we could experience a material adverse impact.
In the ordinary course of
our business, we may collect, process, receive, store, use, generate, transfer, disclose, make accessible, protect, secure, dispose of,
transmit, and share (collectively processing) proprietary, confidential and sensitive information, including personal data (including
health information), intellectual property, trade secrets, and proprietary business information owned or controlled by ourselves or other
parties. We may also share or receive sensitive information with our partners, CROs, CDMOs, or other third parties. Our ability to monitor
these third parties’ information security practices is limited, and these third parties may not have adequate information security
measures in place. If we (or a third party upon whom we rely) experience a security incident or are perceived to have experienced a security
incident, we may also experience adverse consequences.
Our internal computer systems
and those of our CROs, CDMOs, collaborators, contractors, consultants or other third parties are vulnerable to damage from computer viruses,
unauthorized access, cybersecurity threats, and telecommunication and electrical failures. In addition, as many of our personnel work
from home at least part of the time and utilize network connections outside our premises, this poses increased risks to our information
technology systems and data. Cyberattacks, malicious internet-based activity, and online and offline fraud are prevalent and are increasing
in their frequency, sophistication and intensity, and have become increasingly difficult to detect. These threats come from a variety
of sources, including traditional computer “hackers,” “hacktivists,” organized criminal threat actors, threat
actors, personnel (such as through theft or misuse), sophisticated nation-states, and nation-state-supported actors. Some actors now engage
and are expected to continue to engage in cyber-attacks, including without limitation nation-state actors for geopolitical reasons and
in conjunction with military conflicts and defense activities. During times of war and other major conflicts, we, and the third parties
upon which we rely, may be vulnerable to a heightened risk of these attacks, including retaliatory cyber-attacks, that could materially
disrupt our systems and operations, supply chain, and ability to produce and distribute our product candidates. We and the third parties
upon which we rely are subject to a variety of evolving threats, including social-engineering attacks (including through phishing attacks),
malicious code (such as viruses and worms), malware (including as a result of advanced persistent threat intrusions), denial-of-service
(such as credential stuffing), credential harvesting, social engineering attacks (including through phishing attacks), viruses, ransomware,
supply chain attacks, personnel misconduct or error and other similar threats. We may also be the subject of software bugs, server malfunction,
software or hardware failures, loss of data or other information technology assets, adware, telecommunications failures or other similar
issues. In particular, ransomware attacks are becoming increasingly prevalent and severe and can lead to significant interruptions, delays,
or outages in our operations, disruptions to our clinical trials, loss of data (including data related to clinical trials), significant
expense to restore data or systems, reputational loss and the diversion of funds. Extortion payments may alleviate the negative impact
of a ransomware attack, but we may be unwilling or unable to make such payments due to, for example, applicable laws or regulations prohibiting
such payments. Similarly, supply chain attacks have increased in frequency and severity, and we cannot guarantee that third parties and
infrastructure in our supply chain have not been compromised or that they do not contain exploitable defects or bugs that could result
in a breach to our information technology systems or the third-party information technology systems that support us and our services.
Future or past business transactions (such as acquisitions or integrations) could expose us to additional cybersecurity risks and vulnerabilities,
as our systems could be negatively affected by vulnerabilities present in acquired or integrated entities’ systems and technologies.
Furthermore, we may discover security issues that were not found during due diligence of such acquired or integrated entities, and it
may be difficult to integrate companies into our information technology environment and security program.
Any of the previously identified
or similar threats could cause a security incident or other interruption. A security incident or other interruption could result in unauthorized,
unlawful, or accidental acquisition, modification, destruction, loss, alteration, encryption, disclosure of, or access to our sensitive
information. A security incident or other interruption could disrupt our ability (and that of third parties upon whom we rely) to manufacture
or deliver our product candidates.
We may expend significant
resources, or modify our business activities and operations, including our clinical trial activities, in an effort to protect against
security incidents. Certain data privacy and security obligations may require us to implement and maintain specific security measures
or use industry-standard or reasonable security measures to protect our information technology systems and sensitive information.
Although we have implemented
security measures designed to protect against security incidents, there can be no assurance that these measures will be effective. We
have experienced attempts to compromise our information technology systems or otherwise cause a security incident, but, to our knowledge,
such attempts have been unsuccessful. In addition, from time to time, our vendors inform us of security incidents. To date, our review
of such incidents as reported to us did not reveal material information being lost, CERo-specific security vulnerabilities or provide
any useful information or insight into our systems or environment. However, we may not have all information related to such incidents
and future incidents could have an adverse impact on our business.
We may be unable to detect
vulnerabilities in our information technology systems because such threats and techniques change frequently, are often sophisticated in
nature, and may not be detected until after a security incident has occurred. Despite our efforts to identify and remediate exploitable
critical vulnerabilities, if any, in our information technology systems, our efforts may not be successful. Further, we may experience
delays in developing and deploying remedial measures designed to address any such identified vulnerabilities. Any failure to prevent or
mitigate security incidents or improper access to, use of, or disclosure of our clinical data or patients’ personal data could result
in significant liability under state, federal, and international law and may cause a material adverse impact to our reputation, affect
our ability to conduct our clinical trials and potentially disrupt our business.
Applicable data protection
laws, privacy policies and data protection obligations may require us to notify relevant stakeholders of security incidents. Such disclosures
are costly, and the disclosures or the failure to comply with such requirements could lead to adverse consequences. If we (or a third
party upon whom we rely) experience a security incident or are perceived to have experienced a security incident, we may also experience
adverse consequences. These consequences may include: government enforcement actions (for example, investigations, fines, penalties, audits,
and inspections); additional reporting requirements and/or oversight; restrictions on processing sensitive information (including personal
data); litigation (including class claims); indemnification obligations; negative publicity; reputational harm; monetary fund diversions;
interruptions in our operations (including availability of data); financial loss; and other similar harms.
Our contracts may not contain
limitations of liability, and even where they do, there can be no assurance that the limitations of liability in our contracts are sufficient
to protect us from liabilities, damages, or claims related to our data privacy and security obligations.
We cannot be sure that our
insurance coverage will be adequate or sufficient to protect us from or adequately mitigate liabilities arising out of our privacy and
security practices, or that such coverage will continue to be available on commercially reasonable terms or at all, or that such coverage
will pay future claims.
Disruptions at the FDA, the SEC and other
government agencies caused by funding shortages or global health concerns could hinder their ability to hire and retain key leadership
and other personnel, prevent new products and services from being developed or commercialized in a timely manner or otherwise prevent
those agencies from performing normal business functions on which the operation of our business may rely, which could negatively impact
our business.
The ability of the FDA to
review and approve new products can be affected by a variety of factors, including government budget and funding levels, ability to hire
and retain key personnel and accept the payment of user fees, and statutory, regulatory, and policy changes. Average review times at the
agency have fluctuated in recent years as a result. In addition, government funding of the SEC and other government agencies on which
our operations may rely, including those that fund R&D activities is subject to the political process, which is inherently
fluid and unpredictable.
Disruptions at the FDA and
other agencies may also slow the time necessary for new drugs to be reviewed and/or approved by necessary government agencies, which would
adversely affect our business. For example, over the last several years the U.S. government has shut down several times and
certain regulatory agencies, such as the FDA and the SEC, have had to furlough critical FDA, SEC and other government employees and stop
critical activities. If a prolonged government shutdown occurs, it could significantly impact the ability of the FDA to timely review
and process our regulatory submissions, which could have a material adverse effect on our business. Further, in our operations as a public
company, future government shutdowns could impact our ability to access the public markets and obtain necessary capital in order to properly
capitalize and continue our operations.
Since March 2020, when
foreign and domestic inspections of facilities were largely placed on hold, the FDA has been working to resume pre-pandemic levels of
inspection activities, including routine surveillance, bioresearch monitoring and pre-approval inspections. Should the FDA determine that
an inspection is necessary for approval and an inspection cannot be completed during the review cycle due to restrictions on travel or
otherwise, and the FDA does not determine a remote interactive evaluation to be adequate, the FDA has stated that it generally intends
to issue, depending on the circumstances, a complete response letter or defer action on the application until an inspection can be completed.
Business disruptions, including financial
institution distress, could seriously harm our future revenue and financial condition and increase our costs and expenses.
Our operations, and those
of our CROs, CDMOs and other contractors and consultants, could be subject to earthquakes, power shortages, telecommunications failures,
water shortages, floods, hurricanes, typhoons, fires, extreme weather conditions, medical pandemics or epidemics and other natural or
man-made disasters or business interruptions. The occurrence of any of these business disruptions could seriously harm our operations
and financial condition and increase our costs and expenses. Our ability to obtain clinical supplies of our product candidates could be
disrupted if the operations of these suppliers are affected by a man-made or natural disaster or other business interruption.
Our employees, independent contractors,
consultants, commercial partners and vendors may engage in misconduct or other improper activities, including noncompliance with regulatory
standards and requirements.
We are exposed to the risk
of employee fraud or other illegal activity by our employees, independent contractors, consultants, commercial partners and vendors. Misconduct
by these parties could include intentional, reckless and/or negligent conduct that fails to comply with the regulations of the FDA and
other similar foreign regulatory authorities, provide true, complete and accurate information to the FDA and other similar foreign regulatory
authorities, comply with manufacturing standards we have established, comply with healthcare fraud and abuse laws in the United States
and similar foreign fraudulent misconduct laws or report financial information or data accurately or to disclose unauthorized activities
to us. If we obtain FDA approval of any of our product candidates and begin commercializing those products in the United States,
our potential exposure under such laws and regulations will increase significantly, and our costs associated with compliance with such
laws and regulations are also likely to increase. These laws may impact, among other things, our current activities with principal investigators
and research patients, as well as proposed and future sales, marketing and education programs. In particular, the promotion, sales and
marketing of healthcare items and services, as well as certain business arrangements in the healthcare industry, are subject to extensive
laws designed to prevent fraud, kickbacks, self-dealing and other abusive practices. These laws and regulations may restrict or prohibit
a wide range of pricing, discounting, marketing and promotion, structuring and commission(s), certain customer incentive programs and
other business arrangements generally. For more information, see the section entitled, “Business — Healthcare
Laws and Regulations.”
The distribution of biotechnology
and biopharmaceutical products is subject to additional requirements and regulations, including extensive record-keeping, licensing, storage
and security requirements intended to prevent the unauthorized sale of biotechnology and biopharmaceutical products.
The scope and enforcement
of each of these laws is uncertain and subject to rapid change in the current environment of healthcare reform, especially in light of
the lack of applicable precedent and regulations. Ensuring business arrangements comply with applicable healthcare laws, as well as responding
to possible investigations by government authorities, can be time- and resource-consuming and can divert a company’s attention from
other aspects of its business.
It is not always possible
to identify and deter employee misconduct, and our code of ethics and the other precautions we take to detect and prevent inappropriate
conduct may not be effective in controlling unknown or unmanaged risks or losses or in protecting us from governmental investigations
or other actions or lawsuits stemming from a failure to be in compliance with such laws or regulations.
Efforts to ensure that our
business arrangements with third parties will comply with applicable healthcare laws and regulations will involve substantial costs. Because
of the breadth of these laws and the narrowness of the statutory exceptions and safe harbors available, it is possible that some of our
business activities could be subject to challenge under one or more of such laws. It is possible that governmental authorities will conclude
that our business practices may not comply with current or future statutes, regulations or case law involving applicable fraud and abuse
or other healthcare laws and regulations. If our operations are found to be in violation of any of these laws or any other governmental
regulations that may apply to us, we may be subject to significant criminal, civil and administrative sanctions including monetary penalties,
damages, fines, disgorgement, diminished profits and future earnings, individual imprisonment, and exclusion from participation in government
funded healthcare programs, such as Medicare and Medicaid, additional reporting requirements and oversight if we become subject to a corporate
integrity agreement or similar agreement to resolve allegations of non-compliance with these laws, reputational harm, and we may be required
to curtail or restructure our operations, any of which could adversely affect our ability to operate our business and our results of operations.
The shifting compliance environment
and the need to build and maintain robust and expandable systems to comply with multiple jurisdictions with different compliance and/or
reporting requirements increases the possibility that a healthcare company may run afoul of one or more of the requirements. Any action
against us for violation of these laws, even if we successfully defend against it, could cause us to incur significant legal expenses
and divert our management’s attention from the operation of our business.
The provision of
benefits or advantages to physicians to induce or encourage the prescription, recommendation, endorsement, purchase, supply, order
or use of medicinal products is also prohibited in the European Union. The provision of benefits or advantages to induce or
reward improper performance generally is typically governed by the national anti-bribery laws of European Union Member States, and
in respect of the U.K. (which is longer a member of the European Union), the U.K. Bribery Act 2010. Infringement of these
laws could result in substantial fines and imprisonment. European Union Directive 2001/83/EC, which is the European Union Directive
governing medicinal products for human use, further provides that, where medicinal products are being promoted to persons qualified
to prescribe or supply them, no gifts, pecuniary advantages or benefits in kind may be supplied, offered or promised to such persons
unless they are inexpensive and relevant to the practice of medicine or pharmacy. This provision has been transposed into the Human
Medicines Regulations 2012 and so remains applicable in the UK despite its departure from the European Union. Payments made to
physicians in certain European Union Member States must be publicly disclosed. Moreover, agreements with physicians often must be
the subject of prior notification and approval by the physician’s employer, his or her competent professional organization
and/or the regulatory authorities of the individual European Union Member States. These requirements are provided in the national
laws, industry codes or professional codes of conduct, applicable in the European Union Member States. Failure to comply with these
requirements could result in reputational risk, public reprimands, administrative penalties, fines or imprisonment.
The collection, use,
disclosure, transfer, or other processing of personal data regarding individuals in the European Union, including personal health
data, is subject to the European Union General Data Protection Regulation (“GDPR”), which became effective on
May 25, 2018, as well as the United Kingdom’s General Data Protection Regulations (the “UK GDPR”), which,
together with the amended UK Data Protection Act 2018, retains the GDPR in UK national law. The GDPR is wide-ranging in scope
and imposes numerous requirements on companies that process personal data, including requirements relating to processing health and
other sensitive data, obtaining consent of the individuals to whom the personal data relates, providing information to individuals
regarding data processing activities, implementing safeguards to protect the security and confidentiality of personal data,
providing notification of data breaches, and taking certain measures when engaging third-party processors. The GDPR also imposes
strict rules on the transfer of personal data to countries outside the European Union, including the United States, and permits
data protection authorities to impose large penalties for violations of the GDPR, including potential fines of up to
€20 million or 4% of annual global revenues, whichever is greater; UK GDPR mirrors such fines under the GDPR. The
GDPR also confers a private right of action on data subjects and consumer associations to lodge complaints with supervisory
authorities, seek judicial remedies, and obtain compensation for damages resulting from violations of the GDPR. Compliance with
the GDPR will be a rigorous and time-intensive process that may increase our cost of doing business or require us to change our
business practices, and despite those efforts, there is a risk that we may be subject to fines and penalties, litigation, and
reputational harm in connection with European activities. This and other future developments regarding the flow of data across
borders could increase the cost and complexity of delivering our product candidates, if approved, in some markets and may lead to
governmental enforcement actions, litigation, fines and penalties or adverse publicity, which could have an adverse effect on our
reputation and business.
Our product candidates may cause undesirable
side effects or have other properties that could halt their clinical development, prevent their regulatory approval, limit their commercial
potential or result in significant negative consequences.
Future undesirable or unacceptable
side effects caused by our product candidates could cause us or regulatory authorities to interrupt, delay or halt clinical trials and
could result in a more restrictive label or the delay or denial of regulatory approval by the FDA or other comparable foreign regulatory
authorities. Results of our clinical trials could reveal a high and unacceptable severity and prevalence of side effects or unexpected
characteristics. Approved autologous T cell therapies and those under development by other companies have shown frequent rates of CRS,
neurotoxicity, serious infections, prolonged cytopenia and hypogammaglobulinemia, and adverse events have resulted in the death of patients.
Similar adverse events may occur for our T cell product candidates.
In addition, we utilize a
lymphodepletion regimen, which generally includes fludarabine, cyclophosphamide or bendamustine, that may cause serious adverse events.
For instance, because the regimen will cause a transient and sometimes prolonged immune suppression, patients will have an increased risk
of infection, such as to COVID-19, that may be unable to be cleared by the patient and ultimately lead to other serious adverse events
or death. Our lymphodepletion regimen has caused and may also cause prolonged cytopenia and aplastic anemia.
We may also combine the use
of our product candidates with other investigational or approved therapies that may cause separate adverse events or events related to
the combination or potentiate side effects of approved drugs.
If unacceptable toxicities
arise in the development of our product candidates, we could suspend or terminate our trials or the FDA, the EMA or comparable foreign
regulatory authorities could order us to cease clinical trials or deny approval of our product candidates for any or all targeted indications.
Any data safety monitoring board may also suspend or terminate a clinical trial at any time on various grounds, including a finding that
the research patients are being exposed to an unacceptable health risk, including risks inferred from other unrelated immunotherapy trials.
Treatment-related side effects could also affect patient recruitment or the ability of enrolled subjects to complete the trial or result
in potential product liability claims. In addition, these side effects may not be appropriately recognized or managed by the treating
medical staff, as toxicities resulting from T cell therapy are not normally encountered in the general patient population and by medical
personnel. Inadequate training in recognizing or managing the potential side effects of our product candidates could result in patient
deaths. Any of these occurrences may harm our business, financial condition and prospects significantly.
Our product candidates may target healthy
cells expressing target antigens, leading to potentially fatal adverse effects.
Our product candidates target
specific antigens that are also expressed on healthy cells. For example, cell surface phosphatidylserine, the target of CER-1236, has
been observed on activated immune cells, including platelets, and in rapidly dividing cells across various organs including the gastrointestinal
system, hepatic system, cardiovascular system, renal system, pulmonary system, and the central nervous system and related peripheral nervous system. Our
product candidates may target healthy cells, leading to serious and potentially fatal adverse effects. Even though we intend to closely
monitor the side effects of our product candidates in both preclinical studies and clinical trials, we cannot guarantee that products
will not target and kill healthy cells.
Our product candidates may have serious
and potentially fatal cross-reactivity to lipids, peptides or protein sequences within the body.
Our product candidates may
recognize and bind to a peptide unrelated to the target antigen to which it is designed to bind. If this peptide is expressed within normal
tissues, our product candidates may target and kill the normal tissue in a patient, leading to serious and potentially fatal adverse effects.
Additionally, our product candidates may bind with non-targeted lipids, leading to off-target reactivity. Detection of any on-target off-tumor
or non-specific-reactivity may halt or delay any ongoing clinical trials for any CER-T cell based product candidate and prevent or delay
regulatory approval. Unknown binding-reactivity of the CER-T cell binding domain to related proteins could also occur. Any non-specific
binding interactions that impacts patient safety could materially impact our ability to advance our product candidates into clinical trials
or to proceed to marketing approval and commercialization.
If product liability lawsuits are brought
against us, we may incur substantial liabilities and may be required to limit commercialization of our product candidates.
We face an inherent risk
of product liability as a result of the planned clinical testing of our product candidates and will face an even greater risk if we commercialize
any products. For example, we may be sued if our product candidates cause or are perceived to cause injury or are found to be otherwise
unsuitable during clinical testing, manufacturing, marketing or sale. Any such product liability claims may include allegations of defects
in manufacturing, defects in design, packaging, a failure to warn of dangers inherent in the product, negligence, strict liability or
a breach of warranties. Claims could also be asserted under state consumer protection acts. If we cannot successfully defend ourselves
against product liability claims, we may incur substantial liabilities or be required to limit commercialization of our product candidates.
Even successful defense would require significant financial and management resources. Regardless of the merits or eventual outcome, liability
claims may result in:
| ● | decreased demand for our product candidates or products that
we may develop; |
| ● | injury to our reputation; |
| ● | withdrawal of clinical trial participants; |
| ● | initiation of investigations by regulators; |
| ● | costs to defend the related litigation; |
| ● | a diversion of management’s time and our resources; |
| ● | substantial monetary awards to trial participants or patients; |
| ● | product recalls, withdrawals or labeling, marketing or promotional
restrictions; |
| ● | exhaustion of any available insurance and our capital resources; |
| ● | the inability to commercialize any product candidate; and |
| ● | a decline in our stock price. |
Failure to obtain or retain
sufficient product liability insurance at an acceptable cost to protect against potential product liability claims could prevent or inhibit
the commercialization of products we develop, alone or with corporate collaborators. Although we plan on purchasing clinical trial insurance,
such insurance policies also have various exclusions, and we may be subject to a product liability claim for which we have no coverage.
We may have to pay any amounts awarded by a court or negotiated in a settlement that exceed our coverage limitations or that are not covered
by our insurance, and we may not have, or be able to obtain, sufficient capital to pay such amounts. Even if our agreements with any future
corporate collaborators entitle us to indemnification against losses, such indemnification may not be available or adequate should any
claim arise.
Public opinion and scrutiny of cell-based
immuno-oncology therapies for treating cancer, or negative clinical trial results from our cell-based therapy competitors, or auto-immune
cell therapy candidates, may impact public perception of our company and product candidates, or impair our ability to conduct our business.
Our autologous cell therapy
platforms utilizes a relatively novel technology involving the genetic modification of cells, and no CER-T cell-based immunotherapy has
been approved to date. Public perception may be influenced by claims, such as claims that cell-based immunotherapy is unsafe, unethical,
or immoral and, consequently, our approach may not gain the acceptance of the public or the medical community. Negative public reaction
to cell-based immunotherapy in general, or negative clinical trial results from our cell-based therapy competitors, or auto-immune cell
therapy candidates, could result in greater government regulation and stricter labeling requirements of cell-based immunotherapy products,
including any of our product candidates, and could cause a decrease in the demand for any products we may develop. Adverse public attitudes
may adversely impact our ability to enroll patients in clinical trials. More restrictive government regulations or negative public opinion
could have an adverse effect on our business or financial condition and may delay or impair the development and commercialization of our
product candidates or demand for any products we may develop.
For example, in November
2023, the FDA announced that it would be conducting an investigation into reports of T-cell malignancies following BCMA-directed or CD19-directed
autologous CAR-T cell immunotherapies following reports of T cell lymphoma in patients receiving these therapies. In January 2024, the
FDA determined that new safety information related to T cell malignancies should be included in the labeling with boxed warning language
on these malignancies for all BCMA- and CD-19-directed genetically modified autologous T cell immunotherapies. While CER-1236
and our engineered CER-T cells are designed to utilize a different mechanism of action, FDA’s
investigation into CAR-T therapies and other similar actions could result in increased government regulation, unfavorable public
perception and publicity, potential impacts on enrollment in our clinical trials, potential regulatory delays in the testing or approval
of our product candidates, stricter labeling requirements for those product candidates that are approved, and a decrease in demand for
any such product candidates.
Our product candidates for which we intend
to seek approval as biological products may face competition sooner than anticipated, including from other therapeutic modalities.
The Affordable Care Act,
signed into law on March 23, 2010, includes a subtitle called the BPCIA, which created an abbreviated approval pathway for biological
products that are biosimilar to or interchangeable with an FDA-licensed reference biological product. Under the BPCIA, an application
for a biosimilar product may not be submitted to the FDA until four years following the date that the reference product was first
licensed by the FDA. In addition, the approval of a biosimilar product may not be made effective by the FDA until 12 years from
the date on which the reference product was first licensed. During this 12-year period of exclusivity, another company may still market
a competing version of the reference product if the FDA approves a full BLA for the competing product containing the sponsor’s own
preclinical data and data from adequate and well-controlled clinical trials to demonstrate the safety, purity and potency of their product.
We believe that any of our
product candidates approved as a biological product under a BLA should qualify for the 12-year period of exclusivity. However, there is
a risk that this exclusivity could be shortened due to congressional action or otherwise, or that the FDA will not consider our product
candidates to be reference products for competing products, potentially creating the opportunity for generic competition sooner than anticipated.
Other aspects of the BPCIA, some of which may impact the BPCIA exclusivity provisions, have also been the subject of recent litigation.
Moreover, the extent to which a biosimilar, once approved, will be substituted for any one of our products in a way that is similar to
traditional generic substitution for non-biological products is not yet clear, and will depend on a number of marketplace and regulatory
factors that are still developing.
If any approved products
are subject to biosimilar competition sooner than we expect, we will face significant pricing pressure and our commercial opportunity
will be limited.
The insurance coverage and reimbursement
status of newly-approved products is uncertain. Failure to obtain or maintain adequate coverage and reimbursement for new products could
limit our product revenues.
Our ability to commercialize
any of our product candidates successfully will depend in part on the extent to which reimbursement for these products and related treatments
will be available from government health administration authorities, private health insurers, and other organizations. In the United States,
the principal decisions about reimbursement for new therapies are typically made by CMS,
an agency within the United States Department of Health and Human Services. CMS decides whether and to what extent a new therapy
will be covered and reimbursed under Medicare, and private payors tend to follow CMS determinations to a substantial degree. The availability
and extent of reimbursement by governmental and private payors is essential for most patients to be able to afford expensive treatments,
such as cellular immunotherapy. There is significant uncertainty related to the insurance coverage and reimbursement of newly approved
products by government and third-party payors. In particular, there is no body of established practices and precedents for reimbursement
of cellular immunotherapies, and it is difficult to predict what the regulatory authority or private payor will decide with respect to
reimbursement levels for novel products such as ours. Our product candidates may not qualify for coverage or direct reimbursement, or
may be subject to limited reimbursement. If reimbursement or insurance coverage is not available, or is available only to limited levels,
we may not be able to successfully commercialize our product candidates, if approved. Even if coverage is provided, the approved reimbursement
amount may not be sufficient to allow us to establish or maintain pricing to generate income.
In addition, reimbursement
agencies in foreign jurisdictions may be more conservative than those in the United States. Accordingly, in markets outside the United States,
the reimbursement for our product candidates, if approved, may be reduced as compared with the United States and may be insufficient
to generate commercially reasonable revenues and profits. Moreover, increasing efforts by governmental and third-party payors, in the
United States and abroad, to cap or reduce healthcare costs may cause such organizations to limit both coverage and level of reimbursement
for new products approved, and as a result, they may not cover or provide adequate payment for our product candidates. Failure to obtain
or maintain adequate reimbursement for any products for which we receive marketing approval will adversely affect our ability to achieve
commercial success, and could have a material adverse effect on our operating results, our ability to raise capital needed to commercialize
products, and our overall financial condition.
Even if we obtain regulatory and marketing
approval for a product candidate, our product candidates will remain subject to regulatory oversight.
Even if we receive marketing
and regulatory approval for CER-1236 or any other product candidates, regulatory authorities may still impose significant restrictions
on the indicated uses or marketing or impose ongoing requirements for potentially costly post-approval studies. CER-1236 and other product
candidates will also be subject to ongoing regulatory requirements for manufacturing, labeling, packaging, storage, advertising, promotion,
sampling, record-keeping, and submission of safety and other post-market information. The FDA has significant post-market authority, including,
for example, the authority to require labeling changes based on new safety information and to require post-market studies or clinical
trials to evaluate serious safety risks related to the use of a biologic. Any regulatory approvals that we receive for CER-1236 or other
product candidates may also be subject to a REMS, limitations on the approved indicated uses for which the product may be marketed or
to the conditions of approval, or contain requirements for potentially costly post-marketing testing, including post-approval clinical
trials, and surveillance to monitor the quality, safety, and efficacy of the product, all of which could lead to lower sales volume and
revenue. For example, the holder of an approved BLA is obligated to monitor and report adverse events and any failure of a product to
meet the specifications in the BLA. The holder of an approved BLA also must submit new or supplemental applications and obtain FDA
approval for certain changes to the approved product, product labeling, or manufacturing process. Advertising and promotional materials
must comply with FDA rules and are subject to FDA review, in addition to other potentially applicable federal and state laws.
In addition, product manufacturers
and their facilities are subject to payment of user fees and continual review and periodic inspections by the FDA and other regulatory
authorities for compliance with cGMP requirements and adherence to commitments made in the BLA or foreign marketing application. If we,
or a regulatory authority, discover(s) previously unknown problems with a product, such as adverse events of unanticipated severity
or frequency, or problems with the facility where the product is manufactured or disagrees with the promotion, marketing or labeling of
that product, a regulatory authority may impose restrictions relative to that product, the manufacturing facility or us, including requiring
recall or withdrawal of the product from the market or suspension of manufacturing.
If we or our contractors
fail to comply with applicable regulatory requirements following approval of CER-1236 or our other product candidates, a regulatory authority
may:
| ● | issue a warning letter, untitled letter, or Form 483,
asserting that we are in violation of the law; |
| ● | request voluntary product recalls; |
| ● | seek an injunction or impose administrative, civil, or criminal
penalties or monetary fines; |
| ● | suspend or withdraw regulatory approval; |
| ● | suspend any ongoing clinical trials; |
| ● | refuse to approve a pending BLA or comparable foreign marketing
application (or any supplements thereto); |
| ● | restrict the marketing or manufacturing of the product; |
| ● | seize or detain the product or otherwise require the withdrawal
of the product from the market; |
| ● | refuse to permit the import or export of product candidates;
or |
| ● | refuse to allow us to enter into supply contracts, including
government contracts. |
Any government investigation
of alleged violations of law could require us to expend significant time and resources in response and could generate negative publicity.
The occurrence of any event or penalty described above may inhibit our ability to commercialize CER-1236 or other product candidates and
adversely affect our business, financial condition, results of operations, and prospects.
Prior treatments can alter the cancer or
target of CER-T cell therapy and negatively impact chances for achieving clinical activity with our programmed T cells.
Patients with hematological
cancers receive highly toxic lympho-depleting chemotherapy as their initial treatment. These therapies can impact the viability of the
T cells collected from the patient and can contribute to highly variable responses to programmed T cell therapies. Patients could also
have received prior therapies that target the same target antigen on the cancer cells as our intended programmed T cell product candidate
and thereby lead to a selection of cancer cells with low or no expression of the target. Cancers also naturally evolve and select clones
with low or no expression of the target. As a result, our programmed T cell product candidates may not recognize the cancer cell and may
fail to achieve clinical activity. If any of our product candidates do not achieve a sufficient level of clinical activity, we may discontinue
the development of that product candidate, which could adversely affect our business, financial condition, results of operations, and
prospects.
Risks Related to Reliance on Third-Parties
We will rely on third parties to conduct
our clinical trials. If these third parties do not properly and successfully carry out their contractual duties or meet expected deadlines,
we may not be able to obtain regulatory approval of or commercialize our product candidates.
We expect to utilize and
depend upon independent investigators and collaborators, such as medical institutions, CROs, CDMOs and strategic partners to conduct our
preclinical studies under agreements with us and in connection with our clinical trials. We expect to have to negotiate budgets and contracts
with CROs, trial sites and CDMOs which may result in delays to our development timelines and increased costs. We will rely heavily on
these third parties over the course of our clinical trials and we control only certain aspects of their activities. As a result, we have
less direct control over the conduct, timing and completion of these clinical trials and the management of data developed through clinical
trials than would be the case if we were relying entirely upon our own staff. Nevertheless, we are responsible for ensuring that each
of our studies is conducted in accordance with applicable protocol, legal and regulatory requirements and scientific standards and our
reliance on third parties does not relieve us of our regulatory responsibilities. We and these third parties are required to comply with
GCPs, which are regulations and guidelines enforced by the FDA and comparable foreign regulatory authorities for product candidates in
clinical development. Regulatory authorities enforce these GCPs through periodic inspections of trial sponsors, principal investigators
and trial sites. If we or any of these third parties fail to comply with applicable GCP regulations, the clinical data generated in our
clinical trials may be deemed unreliable and the FDA or comparable foreign regulatory authorities may require us to perform additional
clinical trials before approving our marketing applications. We cannot assure you that, upon inspection, such regulatory authorities will
determine that any of our clinical trials comply with the GCP regulations. In addition, our clinical trials must be conducted with biological
product produced under cGMP regulations, including current good tissue practice (“cGTP”) regulations, and will require a large
number of test patients. Our failure or any failure by these third parties to comply with these regulations or to recruit a sufficient
number of patients may require us to repeat clinical trials, which would delay the regulatory approval process. Moreover, our business
may be implicated if any of these third parties violates federal or state fraud and abuse or false claims laws and regulations or healthcare
privacy and security laws.
Any third parties conducting
our clinical trials are not and will not be our employees and, except for remedies available to us under our agreements with such third
parties, we cannot control whether or not they devote sufficient time and resources to our product candidates. These third parties may
also have relationships with other commercial entities, including our competitors, for whom they may also be conducting clinical trials
or other drug development activities, which could affect their performance on our behalf. If these third parties do not successfully carry
out their contractual duties or obligations or meet expected deadlines, if they need to be replaced or if the quality or accuracy of the
clinical data they obtain is compromised due to the failure to adhere to our clinical protocols or regulatory requirements or for other
reasons, our clinical trials may be extended, delayed or terminated and we may not be able to complete development of, obtain regulatory
approval of or successfully commercialize our product candidates. As a result, our financial results and the commercial prospects for
our product candidates would be harmed, our costs could increase and our ability to generate revenue could be delayed.
Switching or adding third
parties to conduct our clinical trials involves substantial cost and requires extensive management time and focus. In addition, changes
in manufacturers often involve changes in manufacturing procedures and processes, which could require that we conduct bridging studies
between our prior clinical supply used in our clinical trials and that of any new manufacturer. We may be unsuccessful in demonstrating
the comparability of clinical supplies which could require the conduct of additional clinical trials. Additionally, there is a natural
transition period when a new third party commences work. As a result, delays occur, which can materially impact our ability to meet our
desired clinical development timelines.
We rely on third parties to manufacture
and store our clinical product supplies, and we may have to rely on third parties to produce and process our product candidates, if approved.
There can be no assurance that we will be able to establish or maintain relationships with such third parties. We may in the future establish
our own manufacturing facility and infrastructure in addition to or in lieu of relying on third parties for the manufacture of our product
candidates, which would be costly, time-consuming and which may not be successful.
Our product candidates are
manufactured in the United States by third parties, and we manage all other aspects of the supply, including planning, oversight,
disposition and distribution logistics. There can be no assurance that we will not experience supply or manufacturing issues in the future.
We have a long-term agreement
in place with a CDMO for the manufacture of CER-1236. However, we have not yet caused our product candidates to be manufactured or processed
on a commercial scale and may not be able to achieve manufacturing and processing and may be unable to create an inventory of mass-produced
product to satisfy demands for any of our product candidates. Our clinical supply will also be limited to small quantities and any latent
defects discovered in our supply could significantly delay our development timelines.
In addition, our actual and
potential future reliance on a limited number of third-party manufacturers exposes us to the following risks:
| ● | We may be unable to identify manufacturers on acceptable
terms or at all because the number of potential manufacturers is limited and the FDA may have questions regarding any replacement contractor.
This may require new testing and regulatory interactions. In addition, a new manufacturer would have to be educated in, or develop substantially
equivalent processes for, production of our products after receipt of FDA questions, if any. |
| ● | Our third-party manufacturers might be unable to timely formulate
and manufacture our product or produce the quantity and quality required to meet our clinical and commercial needs, if any. |
| ● | Contract manufacturers may not be able to execute our manufacturing
procedures appropriately. |
| ● | Manufacturers are subject to ongoing periodic unannounced
inspection by the FDA, the Drug Enforcement Administration and corresponding state agencies to ensure strict compliance with cGMP and
other government regulations and corresponding foreign standards. We do not have control over third-party manufacturers’ compliance
with these regulations and standards. |
| ● | We may not own, or may have to share, the intellectual property
rights to any improvements made by our third-party manufacturers in the manufacturing process for our products. |
| ● | Our future contract manufacturers may not perform as agreed
or may not remain in the contract manufacturing business for the time required to supply our clinical trials or to successfully produce,
store and distribute our products. |
| ● | Our third-party manufacturers could breach or terminate their
agreement with us. |
Our contract manufacturers
would also be subject to the same risks we face in developing our own manufacturing capabilities, as described above. Our current and
potential future CDMOs may also be required to shut down in response to the spread of health epidemics or pandemics, or they may prioritize
manufacturing for therapies or vaccines for other diseases. In addition, our CDMOs have certain responsibilities for storage of raw materials
and in the past have lost or failed to adequately store our raw materials. We will also rely on third parties to store our released product
candidates, and any failure to adequately store our product candidates could result in significant delay to our development timelines.
Any additional or future damage or loss of raw materials or product candidates could materially impact our ability to manufacture and
supply our product candidates. Each of these risks could delay our clinical trials, the approval, if any of our product candidates by
the FDA or the commercialization of our product candidates or result in higher costs or deprive us of potential product revenue.
In addition, we will rely
on third parties to perform release tests on our product candidates prior to delivery to patients. If these tests are not appropriately
done and test data are not reliable, patients could be put at risk of serious harm.
We maintain single supply relationships
for certain key components, and our business and operating results could be harmed if supply is restricted or ends or the price of raw
materials used in our suppliers’ manufacturing process increases.
We are dependent on sole
suppliers or a limited number of suppliers for certain components that are integral to our product candidates, including CER-1236. If
these or other suppliers encounter financial, operating or other difficulties or if our relationship with them changes, we may be unable
to quickly establish or qualify replacement sources of supply and could face production interruptions, delays and inefficiencies. In addition,
technology changes by our vendors could disrupt access to required manufacturing capacity or require expensive, time-consuming development
efforts to adapt and integrate new equipment or processes. Our growth may exceed the capacity of one or more of these suppliers to produce
the needed equipment and materials in sufficient quantities to support our growth. Any one of these factors could harm our business and
growth prospects.
Our product candidates rely on the availability
of specialty raw materials, which may not be available to us on acceptable terms or at all.
Our product candidates, including
CER-1236, require many specialty raw materials, some of which are manufactured by small companies with limited resources and experience
to support a commercial product. In addition, those suppliers normally support blood-based hospital businesses and generally do not have
the capacity to support commercial products manufactured under cGMP by biopharmaceutical firms. The suppliers may be ill-equipped to support
our needs, especially in non-routine circumstances like an FDA inspection or medical crisis, such as widespread contamination. We also
do not have contracts with many of these suppliers and may not be able to contract with them on acceptable terms or at all. Accordingly,
we may experience delays in receiving key raw materials to support clinical or commercial manufacturing.
In addition, some of our
raw materials are currently available from a single supplier, or a small number of suppliers. For example, the type of cell culture media
and cryopreservation buffer that we currently use in our manufacturing process for the CER-T cells are available from multiple suppliers,
but each version may perform differently, requiring us to characterize them and modify our protocols if we change suppliers. Disruption
of our cell manufacturing process may affect product health, fitness, and potentially anti-tumor activity and clinical responses. In addition,
the cell processing equipment and tubing that we use in our current manufacturing process is only available from a single supplier. We
also use certain biologic materials, including certain activating antibodies, that are available from multiple suppliers, but each version
may perform differently, requiring us to characterize them and potentially modify some of our protocols if we change suppliers. We cannot
be sure that these suppliers will remain in business, or that they will not be purchased by one of our competitors or another company
that is not interested in continuing to produce these materials for our intended purpose. If we are required to change suppliers, the
materials may only be available from another supplier on terms that are less favorable to us than the terms under which we currently obtain
the materials. Accordingly, if we no longer have access to these suppliers, we may experience delays in our clinical or commercial manufacturing
which could harm our business or results of operations.
If we or our third-party suppliers use hazardous,
non-hazardous, biological or other materials in a manner that causes injury or violates applicable law, we may be liable for damages.
Our R&D
activities involve the controlled use of potentially hazardous substances, including chemical and biological materials. We and our suppliers
are subject to federal, state and local laws and regulations in the United States governing the use, manufacture, storage, handling
and disposal of medical and hazardous materials. Although we believe that we and our suppliers’ procedures for using, handling,
storing and disposing of these materials comply with legally prescribed standards, we and our suppliers cannot completely eliminate the
risk of contamination or injury resulting from medical or hazardous materials. As a result of any such contamination or injury, we may
incur liability or local, city, state or federal authorities may curtail the use of these materials and interrupt our business operations.
In the event of an accident, we could be held liable for damages or penalized with fines, and the liability could exceed our resources.
We do not have any insurance for liabilities arising from medical or hazardous materials. In addition, any violation in the use, manufacture,
storage, handling and disposal under foreign law may subject us to additional liability.
Compliance with applicable
environmental laws and regulations is expensive, and current or future environmental regulations may impair our research, development
and production efforts, which could harm our business, prospects, financial condition or results of operations.
Risks Related to Government and Regulation
Clinical development and the regulatory
approval process involve a lengthy and expensive process with an uncertain outcome and results of earlier studies and preclinical data,
and trials may not be predictive of future clinical trial results. If our preclinical studies and clinical trials are not sufficient to
support regulatory approval of any of our product candidates, we may incur additional costs or experience delays in completing, or ultimately
be unable to complete, the development of such product candidate.
The research, testing, manufacturing,
labeling, licensure, sale, marketing and distribution of biological products are subject to extensive regulation by the FDA and other
regulatory authorities in the United States and other countries, and such regulations differ from country to country. We are not
permitted to market our product candidates in the United States or in any foreign countries until they receive the requisite licensure
from the applicable regulatory authorities of such jurisdictions. We have not previously submitted a BLA to the FDA or similar licensure
applications to comparable foreign regulatory authorities. A BLA must include extensive preclinical and clinical data and supporting information
to establish the product candidate’s safety, purity and potency for each desired indication. The BLA must also include significant
information regarding the manufacturing controls for the product. We expect the novel nature of our product candidates to create further
challenges in obtaining regulatory approval. Accordingly, the regulatory approval pathway for our product candidates may be uncertain,
complex, expensive and lengthy, and licensure may not be obtained.
We cannot be certain that
our preclinical studies and clinical trial results will be sufficient to support regulatory approval of our product candidates. Clinical
testing is expensive and can take many years to complete and its outcome is inherently uncertain. Human clinical trials are expensive
and difficult to design and implement, in part because they are subject to rigorous regulatory requirements. Failure or delay can occur
at any time during the clinical trial process.
We may experience delays
in obtaining the FDA’s authorization to initiate clinical trials under future INDs and completing ongoing clinical studies of our
product candidates due to a variety of factors. Additionally, we cannot be certain that preclinical studies or clinical trials for our
product candidates will begin on time, not require redesign, enroll an adequate number of subjects on time, or be completed on schedule,
if at all. Clinical trials can be delayed or terminated for a variety of reasons, including delays or failures related to:
| ● | the availability of financial resources to commence and complete
the planned trials |
| ● | the FDA or comparable foreign regulatory authorities disagreeing
as to the design or implementation of our clinical trials; |
| ● | delays in obtaining regulatory approval to commence a clinical
trial; |
| ● | our inability to demonstrate to the satisfaction of the FDA
or the applicable foreign regulatory authority that any of our product candidates are safe, potent and pure; |
| ● | the FDA’s or the applicable foreign regulatory agency’s
disagreement with our trial protocol or the interpretation of data from preclinical studies or clinical trials; |
| ● | our inability to demonstrate that the clinical and other
benefits of any of our product candidates outweigh any safety or other perceived risks; |
| ● | the FDA’s or the applicable foreign regulatory agency’s
requirement for additional preclinical studies or clinical trials; |
| ● | the results of clinical trials may not meet the level of
statistical significance required by the FDA or comparable foreign regulatory authorities for licensure; |
| ● | the data collected from clinical trials of our product candidates
may not be sufficient to the satisfaction of the FDA or comparable foreign regulatory authorities to support the submission of a BLA
or other comparable submission in foreign jurisdictions or to obtain licensure of our product candidates in the United States or
elsewhere; |
| ● | reaching agreement on acceptable terms with prospective CDMOs
and clinical trial sites, the terms of which can be subject to extensive negotiation and may vary significantly among different CDMOs
and clinical trial sites; |
| ● | obtaining IRB or ethics committee approval at each clinical
trial site; |
| ● | recruiting an adequate number of suitable patients to participate
in a clinical trial; |
| ● | having subjects complete a clinical trial or return for post-treatment
follow-up; |
| ● | clinical trial sites deviating from clinical trial protocol
or dropping out of a clinical trial; |
| ● | addressing subject safety concerns that arise during the
course of a clinical trial; |
| ● | adding a sufficient number of clinical trial sites; |
| ● | obtaining sufficient product supply of product candidate
for use in preclinical studies or clinical trials from third-party suppliers; |
| ● | the FDA’s or the applicable foreign regulatory agency’s
findings of deficiencies or failure to approve the manufacturing processes or facilities of third-party manufacturers upon which we rely;
or |
| ● | the approval policies or regulations of the FDA or comparable
foreign regulatory authorities may significantly change in a manner rendering our clinical data insufficient for approval. |
We may experience numerous
adverse or unforeseen events during, or as a result of, preclinical studies and clinical trials that could delay or prevent our ability
to receive marketing approval or commercialize our product candidates, including:
| ● | we may receive feedback from regulatory authorities that
requires us to modify the design of our clinical trials; |
| ● | we may obtain a result from preclinical studies such as a
binder specificity study or a safety toxicology study that require us to modify the design of our clinical trials, abandon our research
efforts for product candidates, or result in delays; |
| ● | clinical trials of our product candidates may produce negative
or inconclusive results and we may decide, or regulators may require us, to conduct additional clinical trials or abandon our research
efforts for our other product candidates; |
| ● | the number of patients required for clinical trials of our
product candidates may be larger than we anticipate, enrollment in these clinical trials may be slower than we anticipate or participants
may drop out of our clinical trials at a higher rate than we anticipate; |
| ● | our third-party contractors may fail to comply with regulatory
requirements, fail to maintain adequate quality controls or be unable to provide us with sufficient product supply to conduct and complete
preclinical studies or clinical trials of our product candidates in a timely manner, or at all; |
| ● | we or our investigators might have to suspend or terminate
clinical trials of our product candidates for various reasons, including non-compliance with regulatory requirements, a finding that
our product candidates have undesirable side effects or other unexpected characteristics or a finding that the participants are being
exposed to unacceptable health risks; |
| ● | the cost of clinical trials of our product candidates may
be greater than we anticipate; |
| ● | the quality of our product candidates or other materials
necessary to conduct preclinical studies or clinical trials of our product candidates may be insufficient or inadequate; |
| ● | regulators may revise the requirements for approving our
product candidates, or such requirements may not be as we anticipate; and |
| ● | future collaborators may conduct clinical trials in ways
they view as advantageous to them but that are suboptimal for us. |
If we are required to conduct
additional clinical trials or other testing of our product candidates beyond those that we currently contemplate, if we are unable to
successfully complete clinical trials of our product candidates or other testing, if the results of these trials or tests are not positive
or are only moderately positive or if there are safety concerns, our business and results of operations may be adversely affected and
we may incur significant additional costs. In addition, costs to treat patients with relapsed or refractory cancer and to treat potential
side effects that may result from our product candidates can be significant. Accordingly, our clinical trial costs are likely to be significantly
higher than those for more conventional therapeutic technologies or drug product candidates.
We could also encounter delays
if a clinical trial is suspended or terminated by us, by the IRBs of the institutions in which such clinical trials are being conducted,
by the Data Safety Monitoring Board for such clinical trial or by the FDA or other regulatory authorities. Such authorities may suspend
or terminate a clinical trial due to a number of factors, including failure to conduct the clinical trial in accordance with regulatory
requirements or our clinical trial protocols, inspection of the clinical trial operations or trial site by the FDA or other regulatory
authorities resulting in the imposition of a clinical hold, unforeseen safety issues or adverse side effects, failure to demonstrate a
benefit from the product candidates, changes in governmental regulations or administrative actions or lack of adequate funding to continue
the clinical trial.
Any delay in obtaining, or
inability to obtain, applicable regulatory approval would delay or prevent commercialization of our product candidates and would materially
adversely impact our business and prospects and our ability to generate revenues from any of these product candidates will be delayed
or not realized at all. In addition, many of the factors that cause, or lead to, a delay in the commencement or completion of clinical
trials may also ultimately lead to the denial of regulatory approval of our product candidates. If one or more of our product candidates
generally prove to be ineffective, unsafe or commercially unviable, our CER-T cell platform would have little, if any, value, which would
have a material and adverse effect on our business, financial condition, results of operations and prospects.
Any of these factors, many
of which are beyond our control, may result in our failing to obtain regulatory approval to market any of our product candidates, or a
delay in such approval, which would significantly harm our business, results of operations, and prospects. Of the large number of biological
products in development, only a small percentage successfully complete the FDA or other regulatory approval processes and are commercialized.
Even if we eventually complete clinical testing and receive licensure from the FDA or applicable foreign regulatory authorities for any
of our product candidates, the FDA or the applicable foreign regulatory may license our product candidates for a more limited indication
or a narrower patient population than we originally requested, and the FDA, or applicable foreign regulatory agency, may not license our
product candidates with the labeling that we believe is necessary or desirable for the successful commercialization of such product candidates.
Our manufacturing process needs to comply
with FDA regulations relating to the quality and reliability of such processes. Any failure to comply with relevant regulations could
result in delays in or termination of our clinical programs and suspension or withdrawal of any regulatory approvals.
In order to commercially
produce our products at a third party’s facility, we will need to comply with the FDA’s cGMP regulations and guidelines, including
cGTPs. We may encounter difficulties in achieving quality control and quality assurance and may experience shortages in qualified personnel.
We are subject to inspections by the FDA and comparable foreign regulatory authorities to confirm compliance with applicable regulatory
requirements. Any failure to follow cGMP, cGTP or other regulatory requirements or delay, interruption or other issues that arise in the
manufacture, fill-finish, packaging, or storage of our CER-T cells as a result of a failure of the facilities or operations of third parties
to comply with regulatory requirements or pass any regulatory authority inspection could significantly impair our ability to develop and
commercialize our CER-T cell programs, including leading to significant delays in the availability of our CER-T cells for our clinical
trials or the termination of or suspension of a clinical trial, or the delay or prevention of a filing or approval of marketing applications
for our CER-T cell product candidates. Significant non-compliance could also result in the imposition of sanctions, including warning
or untitled letters, fines, injunctions, civil penalties, failure of regulatory authorities to grant marketing approvals for our CER-T
cell product candidates, delays, suspension or withdrawal of approvals, license revocation, seizures or recalls of products, operating
restrictions and criminal prosecutions, any of which could damage our reputation and our business.
Even if we receive regulatory approval for
any of our product candidates, we will be subject to ongoing obligations and continued regulatory review, which may result in significant
additional expense. Additionally, our product candidates, if approved, could be subject to labeling and other restrictions and market
withdrawal and we may be subject to penalties if we fail to comply with regulatory requirements or experience unanticipated problems with
our products.
If the FDA, EMA or any other
comparable regulatory authority approves any of our product candidates, the manufacturing processes, labeling, packaging, distribution,
adverse event reporting, storage, advertising, promotion and recordkeeping for the product will be subject to extensive and ongoing regulatory
requirements. These requirements include submissions of safety and other post-marketing information and reports, registration requirements,
applicable product tracking and tracing requirements and continued compliance with cGMPs, including cGTPs, and GCP, for any clinical trials
that we conduct post-approval. Later discovery of previously unknown problems with a product, including adverse events of unanticipated
severity or frequency, or with any future potential manufacturing facilities we may own, third-party manufacturers or manufacturing processes,
or failure to comply with regulatory requirements, may result in, among other things:
| ● | restrictions on the marketing or manufacturing of the product,
withdrawal of the product from the market, or voluntary product recalls; |
| ● | fines, untitled or warning letters or holds on clinical trials; |
| ● | refusal by the FDA, the EMA or any other comparable regulatory
authority to approve pending applications or supplements to approved applications filed by us, or suspension or revocation of product
approvals; |
| ● | product seizure or detention, or refusal to permit the import
or export of products; and |
| ● | injunctions or the imposition of civil or criminal penalties. |
Moreover, if any of our product
candidates are approved, our product labeling, advertising and promotion will be subject to regulatory requirements and continuing regulatory
review. The FDA strictly regulates the promotional claims that may be made about biopharmaceutical products. In particular, a product
may not be promoted for uses that are not approved by the FDA as reflected in the product’s approved labeling.
Any government investigation
of alleged violations of law could require us to expend significant time and resources in response and could generate negative publicity.
The occurrence of any event or penalty described above may inhibit our or our collaborators’ ability to commercialize our product
candidates, and harm our business, financial condition and results of operations.
In addition, the policies
of the FDA, the EMA and other comparable regulatory authorities may change and additional government regulations may be enacted that could
prevent, limit or delay regulatory approval of our product candidates. If we are slow or unable to adapt to changes in existing requirements
or the adoption of new requirements or policies, or if we are not able to maintain regulatory compliance, we may lose any marketing approval
that we may have obtained, which would adversely affect our business, prospects and ability to achieve or sustain profitability.
We also cannot predict the
likelihood, nature or extent of government regulation that may arise from future legislation or administrative or executive action, either
in the United States or abroad. If we are slow or unable to adapt to changes in existing requirements or the adoption of new requirements,
or if we are unable to maintain regulatory compliance, marketing approval that has been obtained may be lost and we may not achieve or
sustain profitability.
Regulatory requirements in the United States
and abroad governing cell therapy products have changed frequently and may continue to change in the future, which could negatively impact
our ability to complete clinical trials and commercialize our product candidates in a timely manner, if at all.
Regulatory requirements in
the United States and abroad governing cell therapy products have changed frequently and may continue to change in the future. In
2016, the FDA established the Office of Tissues and Advanced Therapies (“OTAT”) within its Center for Biologics Evaluation
and Research to consolidate the review of gene therapy and related products, and has established the Cellular, Tissue and Gene Therapies
Advisory Committee, among others, to advise this review. In September 2022, the FDA announced retitling of OTAT to the Office of
Therapeutic Products (“OTP”) and elevation of OTP to a “Super Office” to meet its growing cell and gene therapy
workload. In addition, under guidelines issued by the National Institute of Health (the “NIH”), gene therapy clinical trials
are also subject to review and oversight by an institutional biosafety committee (“IBC”), a local institutional committee
that reviews and oversees research utilizing recombinant or synthetic nucleic acid molecules at that institution. Before a clinical trial
can begin at any institution, that institution’s institutional review board, or IRB, and its IBC assesses the safety of the research
and identifies any potential risk to public health or the environment. While the NIH guidelines are not mandatory unless the research
in question is being conducted at or sponsored by institutions receiving NIH funding of recombinant or synthetic nucleic acid molecule
research, many companies and other institutions not otherwise subject to the NIH guidelines voluntarily follow them. Moreover, serious
adverse events or developments in clinical trials of gene therapy product candidates conducted by others may cause the FDA or other regulatory
bodies to initiate a clinical hold on our clinical trials or otherwise change the requirements for approval of any of our product candidates.
Although the FDA decides whether individual cell and gene therapy protocols may proceed, the review process and determinations of other
reviewing bodies can impede or delay the initiation of a clinical trial, even if the FDA has reviewed the trial and approved its initiation.
We may seek fast track and breakthrough
therapy designations or priority review for one or more of our product candidates, but we might not receive such designation or priority
review, and even if we do, such designation or priority review may not lead to a faster development or regulatory review or approval process,
and does not assure FDA approval of our product candidates. Even if a product qualifies for such designation or priority review, the FDA
may later decide that the product no longer meets the conditions for qualification or decide that the time period for FDA review or approval
will not be shortened.
We may seek fast track, breakthrough
therapy, and/or regenerative medicine advanced therapy designations or priority review for one or more of our product candidates.
The FDA may issue a fast
track designation to a product candidate if it is intended, whether alone or in combination with one or more other products, for the treatment
of a serious or life-threatening disease or condition, and it demonstrates the potential to address unmet medical needs for such a disease
or condition. Fast track designation applies to the combination of the product and the specific indication for which it is being studied.
The sponsor of a new biologic may request that the FDA designate the biologic as a fast track product at any time during the clinical
development of the product. For fast track products, sponsors may have greater interactions with the FDA during product development. A
fast track product may also be eligible for rolling review, where the FDA may consider for review sections of the BLA on a rolling basis
before the complete application is submitted, if the sponsor provides a schedule for the submission of the sections of the BLA, the FDA
agrees to accept sections of the BLA and determines that the schedule is acceptable, and the sponsor pays any required user fees upon
submission of the first section of the BLA. However, the FDA’s goal for reviewing a BLA fast track application under the PDUFA
does not begin until the last section of the application is submitted. Fast track designation may be withdrawn by the FDA if the FDA believes
that the designation is no longer supported by data emerging in the clinical trial process.
A breakthrough therapy is
defined as a product candidate that is intended, alone or in combination with one or more other drugs, to treat a serious or life-threatening
disease or condition, and preliminary clinical evidence indicates that the product candidate may demonstrate substantial improvement over
existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development.
For product candidates that have been designated as breakthrough therapies, interaction and communication between the FDA and the sponsor
of the trial can help to identify the most efficient path for clinical development while minimizing the number of patients placed in ineffective
control regimens. Product candidates designated as breakthrough therapies by the FDA are also eligible for priority review if supported
by clinical data at the time of the submission of the BLA.
Fast track designation, priority
review, and breakthrough therapy designation are within the discretion of the FDA. Accordingly, even if we believe that one of our
product candidates meets the criteria for any such designation, the FDA may disagree and instead determine not to make such designation.
In any event, the receipt of such designation may expedite the development or approval process, but do not change the standards for approval.
Even if a product qualifies for one or more of these programs, the FDA may later decide that the product no longer meets the conditions
for qualification or decide that the time period for FDA review or approval will not be shortened.
We may seek approval of our product candidates,
where applicable, under the FDA’s accelerated approval pathway. This pathway may not lead to a faster development, regulatory review
or approval process and does not increase the likelihood that our product candidates will receive marketing approval.
A product may be eligible
for accelerated approval if it is designed to treat a serious or life-threatening disease or condition and generally provides a meaningful
advantage over available therapies upon a determination that the product candidate has an effect on a surrogate endpoint or intermediate
clinical endpoint that is reasonably likely to predict clinical benefit or on a clinical endpoint that can be measured earlier than irreversible
morbidity or mortality, (“IMM”) that is reasonably likely to predict an effect on IMM or other clinical benefit. The FDA considers
a clinical benefit to be a positive therapeutic effect that is clinically meaningful in the context of a given disease, such as IMM. For
the purposes of accelerated approval, a surrogate endpoint is a marker, such as a laboratory measurement, radiographic image, physical
sign or other measure that is thought to predict clinical benefit, but is not itself a measure of clinical benefit. An intermediate clinical
endpoint is a clinical endpoint that can be measured earlier than an effect on irreversible morbidity or mortality that is reasonably
likely to predict an effect on irreversible morbidity or mortality or other clinical benefit. The accelerated approval pathway may be
used in cases in which the advantage of a new drug over available therapy may not be a direct therapeutic advantage, but is a clinically
important improvement from a patient and public health perspective. If granted, accelerated approval is usually contingent on the sponsor’s
agreement to conduct, in a diligent manner, additional post-approval confirmatory studies to verity and describe the drug’s clinical
benefit. Under the FDORA, the FDA is permitted to require, as appropriate, that a post-approval confirmatory study or studies be underway
prior to approval or within a specified time period after the date of accelerated approval was granted. FDORA also requires sponsors to
send updates to the FDA every 180 days on the status of such studies, including progress toward enrollment targets, and the FDA must
promptly post this information publicly. FDORA also gives the FDA increased authority to withdraw approval of a drug or biologic granted
accelerated approval on an expedited basis if the sponsor fails to conduct such studies in a timely manner, send the necessary updates
to the FDA, or if such post-approval studies fail to verify the drug’s predicted clinical benefit. Under FDORA, the FDA is empowered
to take action, such as issuing fines, against companies that fail to conduct with due diligence any post-approval confirmatory study
or submit timely reports to the agency on their progress. In addition, the FDA currently requires, unless otherwise informed by the agency,
pre-approval of promotional materials for products receiving accelerated approval, which could adversely impact the timing of the commercial
launch of the product. Thus, even if we seek to utilize the accelerated approval pathway, we may not be able to obtain accelerated approval
and, even if we do, we may not experience a faster development, regulatory review or approval process for that product. There can be no
assurance that the FDA would allow any of the product candidates we may develop to proceed on an accelerated approval pathway, and even
if the FDA did allow such pathway, there can be no assurance that such submission or application will be accepted or that any expedited
development, review or approval will be granted on a timely basis, or at all. Moreover, even if we received accelerated approval, any
post-approval studies required to confirm and verify clinical benefit may not show such benefit, which could lead to withdrawal of any
approvals we have obtained. Receiving accelerated approval does not assure that the product’s accelerated approval will eventually
be converted to a traditional approval.
We may not be able to obtain orphan drug
exclusivity for one or more of our product candidates, and even if we do, that exclusivity may not prevent the FDA from approving other
competing products.
Regulatory authorities may
designate drugs for relatively small patient populations as “orphan” drugs. Generally, if a product with an orphan drug designation
subsequently receives the first marketing approval for the indication for which it has such designation, the product is entitled to a
period of market exclusivity, which, subject to certain exceptions, precludes the FDA from approving another marketing application for
the same drug for the same indication for that time period. The applicable market exclusivity period is seven years in the United States.
Obtaining orphan drug exclusivity
for our product candidates may be important to our commercial strategy. If a competitor obtains orphan drug exclusivity for and approval
of a product with the same indication as our product candidates before we do, and if the competitor’s product is the same drug or
a similar medicinal product as ours, we could be excluded from the market. Even if we obtain orphan drug exclusivity after FDA approval,
we may not be able to maintain it. For example, if a competitive product that is the same drug or a similar medicinal product as our product
candidate is shown to be clinically superior to our product candidate, any orphan drug exclusivity we have obtained will not block the
approval of such competitive product. In addition, orphan drug exclusivity will not prevent the approval of a product that is the same
drug as our product candidates if the FDA finds that we cannot assure the availability of sufficient quantities of the drug to meet the
needs of the persons with the disease or condition for which the drug was designated. If one or more of these events occur, it could have
a material adverse effect on our company.
We are subject to stringent and changing
privacy laws, regulations and standards as well as policies, contracts and other obligations related to data privacy and security. Our
actual or perceived failure to comply with such obligations could lead to enforcement or litigation (that could result in fines or penalties),
a disruption of clinical trials or commercialization of products, reputational harm, or other adverse business effects.
In the ordinary course of
business, we will collect, receive, store, process, use, generate, transfer, disclose, make accessible, protect, secure, dispose of, transmit
and share (collectively, processing) personal data and other sensitive information, including, but not limited to, proprietary and confidential
business information, trade secrets, intellectual property, and information we collect about patients in connection with clinical trials.
Accordingly, we are, or may become, subject to numerous federal, state, local and international data privacy and data security laws, regulations,
guidance, and industry standards as well as external and internal privacy and data security policies, contracts and other obligations
that apply to our processing of personal data and the processing of personal data on our behalf.
In the United States,
federal, state, and local governments have enacted numerous data privacy and security laws, including data breach notification laws, personal
data privacy laws, consumer protection laws and other similar laws (e.g., unfair or deceptive acts or practices pursuant to Section 5(a) of
the Federal Trade Commission Act). For example, HIPAA, as amended by the Health Information Technology for Economic and Clinical Health
Act (“HITECH”), and their respective implementing regulations, imposes requirements relating to the privacy, security and
transmission of protected health information. Among other things, HITECH, through its implementing regulations, makes certain of HIPAA’s
privacy and security standards directly applicable to business associates, defined as a person or organization, other than a member of
a covered entity’s workforce, that creates, receives, maintains or transmits protected health information for or on behalf of a
covered entity for a function or activity regulated by HIPAA as well as their covered subcontractors.
In addition, the California
Consumer Privacy Act (“CCPA”) applies to personal information of consumers, business representatives, and employees, and creates
individual privacy rights and places increased privacy and security obligations on entities handling personal data of consumers or households.
The CCPA requires covered companies to provide disclosures to California consumers, affords California residents certain rights related
to their personal data, including the right to opt-out of certain sales of personal data, and allow for a new cause of action for certain
data breaches. Although there are limited exemptions for clinical trial data under the CCPA, as our business progresses, the CCPA may
become applicable and significantly impact our business activities and exemplifies the vulnerability of our business to evolving regulatory
environment related to personal data and protected health information. Furthermore, the California Privacy Rights Act of 2020,
effective January 1, 2023, expands the CCPA’s requirements, including by applying to personal information of business representatives
and employees and establishing a new regulatory agency to implement and enforce the law. In addition, other states, such as Virginia and
Colorado, have also passed comprehensive privacy laws, and similar laws are being considered in several other states, as well as at the
federal and local levels. While these states, like the CCPA, also exempt some data processed in the context of clinical trials, these
developments further complicate compliance efforts, and increase legal risk and compliance costs for us and the third parties upon whom
we rely. Moreover, data privacy and security laws have been proposed at the federal, state, and local levels in recent years, which
could further complicate compliance efforts.
Outside the United States,
there are an increasing number of laws, regulations and industry standards concerning privacy, data protection, information security and
cross-border personal data transfers. For example, GDPR, UK GDPR, and China’s Personal Information Protection Law impose strict
requirements for processing personal data. Failure to comply with the requirements of the GDPR and the applicable national data protection
laws of the European Union Member States may result in fines of up to €20,000,000 or up to 4% of the total worldwide annual turnover
of the preceding financial year, whichever is higher, other administrative penalties, and private litigation related to processing of
personal data brought by classes of data subjects or consumer protection organizations authorized at law to represent their interests.
If we cannot implement a valid compliance mechanism for cross-border data transfers, we may face increased exposure to regulatory actions,
substantial fines, and injunctions against processing or transferring personal data from Europe or other foreign jurisdictions. The inability
to import personal data to the United States could significantly and negatively impact our business operations, including by limiting
our ability to conduct clinical trial activities in Europe and elsewhere; limiting our ability to collaborate with parties that are subject
to such cross-border data transfer or localization laws; or requiring us to increase our personal data processing capabilities and infrastructure
in foreign jurisdictions at significant expenses. European regulators have also ordered certain companies to suspend or permanently cease
certain transfers out of Europe for allegedly violating the GDPR’s cross-border data transfer limitations.
In addition, privacy advocates and industry groups
have proposed, and may propose, standards with which we are legally or contractually bound to comply. We are also bound by contractual
obligations related to data privacy and security, and our efforts to comply with such obligations may not be successful. If any of our
privacy policies or related materials or statements are found to be deficient, lacking in transparency, deceptive, unfair, or misrepresentative
of our practices, we may be subject to investigation, enforcement actions by regulators or other adverse consequences.
Our obligations related to
data privacy and security are quickly changing in an increasingly stringent fashion, creating some uncertainty as to the effective future
legal framework. Additionally, these obligations may be subject to differing applications and interpretations, which may be inconsistent
or conflict among jurisdictions. As a result, preparing for and complying with these obligations requires significant resources and may
necessitate changes to our information technologies, systems and practices, as well as those of any third-party collaborators, service
providers, contractors, consultants or other third parties that process personal data on our behalf.
Although we endeavor to comply
with all applicable privacy and security obligations, we may at times fail to do so or may be perceived to have failed to do so. Moreover,
despite our efforts, we may not be successful in achieving compliance if our employees, third-party collaborators, service providers,
contractors or consultants fail to comply with such obligations, which could negatively impact our business operations and compliance
posture. For example, any failure by a third-party service provider to comply with applicable law, regulations, or contractual obligations
could result in adverse effects, including inability to or interruption in our ability to operate our business and proceedings against
us by governmental entities or others. If we fail, or are perceived to have failed, to address or comply with obligations related to data
privacy and security obligations, we could face significant consequences. These consequences may include, but are not limited to, government
enforcement actions (e.g., investigations, fines, penalties, audits and inspections, and similar); litigation (including class-related
claims); additional reporting requirements and/or oversight; temporary or permanent bans on all or some processing of personal data; orders
to destroy or not use personal data; and imprisonment of company officials. Any of these events could have a material adverse effect on
our reputation, business, or financial condition.
The impact of recent healthcare reform legislation
and other changes in the healthcare industry and in healthcare spending on us is currently unknown, and may adversely affect our business
model.
Our revenue prospects could
be affected by changes in healthcare spending and policy in the United States and abroad. We operate in a highly regulated industry
and new laws, regulations or judicial decisions, or new interpretations of existing laws, regulations or decisions, related to healthcare
availability, the method of delivery or payment for healthcare products and services could negatively impact our business, operations
and financial condition.
There have been, and likely
will continue to be, legislative and regulatory proposals at the foreign, federal and state levels directed at broadening the availability
of healthcare and containing or lowering the cost of healthcare. For more information, see the section of this report titled “Business
– Healthcare Laws and Regulations – Healthcare Reform.”
The continuing efforts of
the government, insurance companies, managed care organizations and other payors of healthcare services to contain or reduce costs of
healthcare and/or impose price controls may adversely affect:
| ● | the demand for our product candidates, if we obtain regulatory
approval; |
| ● | our ability to set a price that we believe is fair for our
products; |
| ● | our ability to obtain coverage and reimbursement approval
for a product; |
| ● | our ability to generate revenue and achieve or maintain profitability; |
| ● | the level of taxes that we are required to pay; and |
| ● | the availability of capital. |
Any reduction in reimbursement
from Medicare or other government programs may result in a similar reduction in payments from private payors, which may adversely affect
our future profitability.
Our business could be negatively impacted
by environmental, social and corporate governance matters or our reporting of such matters.
Investors have increased
their emphasis on the environmental, social and governance (“ESG”) practices of companies across all industries, including
the environmental impact of operations and human capital management. Expectations regarding voluntary ESG initiatives and disclosures
may result in increased costs (including but not limited to increased costs related to compliance, stakeholder engagement, contracting
and insurance), enhanced compliance or disclosure obligations, or other adverse impacts to our business, financial condition, or results
of operations.
While we have internal efforts
directed at ESG matters and preparations for any increased required future disclosures, such initiatives may be costly and may not have
the desired effect. We may be perceived to be not acting responsibly in connection with these matters, which could negatively impact us.
Moreover, we may not be able to successfully complete such initiatives due to factors that are within or outside of our control. Even
if this is not the case, our actions may subsequently be determined to be insufficient by various stakeholders, and we may be subject
to investor or regulator engagement on our ESG efforts, even if such initiatives are currently voluntary.
Certain market participants,
including major institutional investors and capital providers, use third-party benchmarks and scores to assess companies’ ESG profiles
in making investment or voting decisions. A failure to comply with investor expectations and standards, which are evolving and vary considerably,
or the perception that we have not responded appropriately to the growing concern for ESG issues, could result in reputational harm to
our business and could have an adverse effect on us. To the extent ESG matters negatively impact our reputation, it may also negatively
impact our share price as well as our access to and cost of capital and impede our ability to compete as effectively to attract and retain
employees, which may adversely impact our operations.
Our ability to utilize our net operating
loss carryforwards and certain other tax attributes may be limited.
Under current law, federal
net operating losses incurred in tax years beginning after December 31, 2017, may be carried forward indefinitely, but the deductibility
of such federal net operating losses is limited to 80% of taxable income. It is uncertain if and to what extent various states will conform
to federal tax laws. Under Sections 382 and 383 of the Code, and corresponding provisions of state law, if a corporation undergoes an
“ownership change” (generally defined as a greater than 50 percentage point change (by value) in the equity ownership of certain
stockholders over a rolling three-year period), the corporation’s ability to use its pre-change net operating loss carryforwards
and other pre-change tax attributes to offset its post-change income or taxes may be limited. We have not yet completed a Section 382
or Section 383 analysis, and therefore, there can be no assurances that any previously experienced ownership changes have not materially
limited our utilization of affected net operating loss carryforwards or other tax attributes. We may experience ownership changes in the
future, including in connection with the proposed Business Combination as a result of shifts in our stock ownership. We anticipate incurring
significant additional net losses for the foreseeable future, and our ability to utilize net operating loss carryforwards associated with
any such losses to offset future taxable income may be limited to the extent we incur future ownership changes. In addition, at the state
level, there may be periods during which the use of net operating loss carryforwards is suspended or otherwise limited, which could accelerate
or permanently increase state taxes owed. As a result, we may be unable to use all or a material portion of our net operating loss carryforwards
and other tax attributes, which could adversely affect our future cash flows.
Changes in tax laws or regulations that
are applied adversely to us or our customers may have a material adverse effect on our business, cash flow, financial condition or results
of operations.
New income, sales, use or
other tax laws, statutes, rules, regulations or ordinances could be enacted at any time, which could adversely affect our business operations
and financial performance. Further, existing tax laws, statutes, rules, regulations or ordinances could be interpreted, changed, modified
or applied adversely to us. For example, the Biden administration and Congress have proposed various U.S. federal tax law changes,
which if enacted could have a material impact on our business, cash flows, financial condition or results of operations. In addition,
it is uncertain if and to what extent various states will conform to federal tax laws. Future tax reform legislation could have a material
impact on the value of our deferred tax assets, could result in significant one-time charges, and could increase our future U.S. tax
expense.
Even if we obtain FDA approval of any of
our product candidates, we may never obtain approval or commercialize such products outside of the United States, which would limit
our ability to realize their full market potential.
In order to market any products
outside of the United States, we must establish and comply with numerous and varying regulatory requirements of other countries regarding
safety and efficacy. Clinical trials conducted in one country may not be accepted by regulatory authorities in other countries, and regulatory
approval in one country does not mean that regulatory approval will be obtained in any other country. Approval procedures vary among countries
and can involve additional product testing and validation and additional administrative review periods.
Seeking foreign regulatory
approvals could result in significant delays, difficulties and costs for us and may require additional preclinical studies or clinical
trials which would be costly and time consuming. Regulatory requirements can vary widely from country to country and could delay or prevent
the introduction of our products in those countries. Satisfying these and other regulatory requirements is costly, time consuming, uncertain
and subject to unanticipated delays. In addition, our failure to obtain regulatory approval in any country may delay or have negative
effects on the process for regulatory approval in other countries. We do not have any product candidates approved for sale in any jurisdiction,
including international markets, and we do not have experience in obtaining regulatory approval in international markets. If we fail to
comply with regulatory requirements in international markets or to obtain and maintain required approvals, our ability to realize the
full market potential of our products will be harmed.
Our business operations and current and
future relationships with healthcare professionals, principal investigators, consultants, customers and third-party payors in the United States
and elsewhere may be subject, directly or indirectly, to applicable anti-kickback, fraud and abuse, false claims, physician payment transparency,
health information privacy and security and other healthcare laws and regulations, which could expose us to substantial penalties.
Healthcare providers, physicians
and third-party payors in the United States and elsewhere will play a primary role in the recommendation and prescription of any
product candidates for which we obtain marketing approval. Our current and future arrangements with healthcare professionals, principal
investigators, consultants, customers and third-party payors may expose us to broadly applicable fraud and abuse and other healthcare
laws, including, without limitation, the U.S. federal Anti-Kickback Statute and the U.S. federal False Claims Act, that may
constrain the business or financial arrangements and relationships through which we sell, market and distribute any product candidates
for which we obtain marketing approval. In addition, we may be subject to physician payment transparency laws and patient privacy and
security regulation by the U.S. federal government and by the states and foreign jurisdictions in which we conduct our business.
For more information, see the section of this report titled “Business – Healthcare Laws and Regulations.”
Because of the breadth of
these laws and the narrowness of their exceptions and safe harbors, it is possible that our business activities can be subject to challenge
under one or more of such laws. The scope and enforcement of each of these laws is uncertain and subject to rapid change in the current
environment of healthcare reform. Federal and state enforcement bodies have continued their scrutiny of interactions between healthcare
companies and healthcare providers, which has led to a number of significant investigations, prosecutions, convictions and settlements
in the healthcare industry.
Efforts to ensure that our
internal operations and future business arrangements with third parties will comply with applicable healthcare laws and regulations will
involve substantial costs. If our operations are found to be in violation of any of these laws or any other governmental regulations that
may apply to us, we may be subject to significant civil, criminal and administrative penalties, including, without limitation, damages,
monetary fines, imprisonment, disgorgement of profits, possible exclusion from participation in Medicare, Medicaid and other federal healthcare
programs, contractual damages, reputational harm, diminished profits and future earnings, additional reporting or oversight obligations
if we become subject to a corporate integrity agreement or other agreement to resolve allegations of non-compliance with the law and curtailment
or restructuring of our operations, any of which could adversely affect our ability to operate our business and pursue our strategy. If
any of the physicians or other healthcare providers or entities with whom we expect to do business, including future collaborators, are
found not to be in compliance with applicable laws, they may be subject to criminal, civil or administrative sanctions, including exclusions
from participation in government healthcare programs, which could also affect our business.
If we fail to comply with environmental,
health and safety laws and regulations, we could become subject to fines or penalties or incur costs that could have a material adverse
effect on the success of our business.
We are subject to numerous
environmental, health and safety laws and regulations, including those governing laboratory procedures and the handling, use, storage,
treatment and disposal of hazardous materials and wastes. Our operations involve the use of hazardous and flammable materials, including
chemicals and biological and radioactive materials. Our operations also produce hazardous waste products. We generally contract with third
parties for the disposal of these materials and wastes. We cannot eliminate the risk of contamination or injury from these materials.
In the event of contamination or injury resulting from our use of hazardous materials, we could be held liable for any resulting damages,
and any liability could exceed our resources. We also could incur significant costs associated with civil or criminal fines and penalties.
Although we maintain workers’
compensation insurance to cover us for costs and expenses we may incur due to injuries to our employees resulting from the use of hazardous
materials, this insurance may not provide adequate coverage against potential liabilities. We do not maintain insurance for environmental
liability or toxic tort claims that may be asserted against us in connection with our storage or disposal of biological, hazardous or
radioactive materials.
We may be affected by regulatory responses
to climate-related issues.
The Biden administration
has made climate change and the limitation of greenhouse gas (“GHG”) emissions one of its primary objectives. Several states
and other geographic regions in the United States have also adopted legislation and regulations to reduce emissions of GHGs.
On March 6, 2024, the SEC
finalized new rules for public companies that will require extensive climate-related disclosures and significant analysis of the impact
of climate-related issues on our business strategy, results of operations, and financial condition (the “SEC Climate Disclosure
Rules”). The new rules will require us to disclose our material climate-related risks and opportunities, GHG emissions inventory,
climate-related targets and goals, and financial impacts of physical and transition risks. As a result of the SEC Climate Disclosure Rules,
our legal, accounting, and other compliance expenses may increase significantly, and compliance efforts may divert management time and
attention. We may also be exposed to legal or regulatory action or claims as a result of these new regulations. All of these risks could
have a material adverse effect on our business, financial position, and/or stock price.
Risks Related to Intellectual Property
Our intellectual property rights are valuable,
and any inability to protect them could reduce the value of our products, services and brand.
The loss of any procured
intellectual property rights in our products could permit our competitors to manufacture their own version of our products. We have attempted
to protect our intellectual property rights in our products through a combination of patents, confidentiality agreements, non-compete
agreements and other contractual protection mechanisms, and we will continue to do so. While we intend to defend against threats to our
intellectual property, our patents or various contractual protections may not adequately protect our intellectual property. In addition,
we could be required to expend significant resources to defend our rights to proprietary information, and may not be successful in such
defense.
As such, we may not be successful
in preventing third parties from infringing, copying or misappropriating our intellectual property. There can also be no assurance that
pending patent applications owned by us will result in patents being issued to us, that patents issued to or licensed by us in the past
or in the future will not be challenged or circumvented by competitors or that such patents will be found to be valid or sufficiently
broad to protect our products or to provide us with any competitive advantage. Third parties could also obtain patents that may require
us to negotiate to obtain licenses to conduct our business, and any required licenses may not be available on reasonable terms or at all.
We also rely on confidentiality and non-compete agreements with certain employees, independent distributors, consultants and other parties
to protect, in part, trade secrets and other proprietary rights. There can be no assurance that these agreements will not be breached,
that we will have adequate remedies for any breach, that others will not independently develop substantially equivalent proprietary information
or that third parties will not otherwise gain access to our trade secrets or proprietary knowledge.
It is difficult and costly to protect our
proprietary rights, and we may not be able to ensure their protection. We cannot assure investors that any of the currently pending or
future patent applications will result in granted patents, nor can we predict how long it will take for such patents to be granted.
Our commercial success will
depend in part on us obtaining and maintaining patent protection and trade secret protection of our current and future product candidates,
as well as successfully defending these patents against third-party challenges. Our ability to stop third parties from making, using,
selling, offering to sell or importing our product candidates is dependent upon the extent to which we have rights under valid and enforceable
patents or trade secrets that cover these activities and the right under our licensed patents to contest alleged infringement.
The patent positions of biotechnology
and pharmaceutical companies can be highly uncertain and involve complex legal and factual questions for which important legal principles
remain unresolved. No consistent policy regarding the breadth of claims allowed in pharmaceutical patents has emerged to date in the United States
or in many jurisdictions outside of the United States. Changes in either the patent laws or interpretations of patent laws in the
United States and other countries may diminish the value of our owned or licensed intellectual property. Accordingly, we cannot predict
the breadth of claims that may be enforced in the patents that may be issued from the applications we currently or may in the future own
or license from third parties. Further, if any patents we obtain or license are deemed invalid or unenforceable, our ability to commercialize
or license our technology could be adversely affected.
Others have filed, and in
the future are likely to file, patent applications covering products and technologies that are similar, identical or competitive to ours
or important to our business. We cannot be certain that any patent application owned by a third party will not have priority over patent
applications filed or in-licensed by us, or that we will not be involved in interference, opposition or invalidity proceedings before
U.S. or non-U.S. patent offices.
The degree of future protection
for our proprietary rights is uncertain because legal means afford only limited protection and may not adequately protect our rights or
permit us to gain or keep our competitive advantage. For example:
| ● | others may be able to make product candidates or develop
a platform similar to, or better than, ours in a way that is not covered by the claims of our licensed or owned patents; |
| ● | others may be able to make compounds that are similar to
our product candidates but that are not covered by the claims of patents we own or that are licensed to us; |
| ● | we or our prospective licensors or future collaborators might
not have been the first to make the inventions covered by any pending patent applications issued patents that we own or license; |
| ● | we or our prospective licensors or future collaborators might
not have been (or may not be in the future) the first to file patent applications for certain of our inventions; |
| ● | others may independently develop similar or alternative technologies
or duplicate any of our technologies without infringing our intellectual property rights; |
| ● | our pending patent applications may not lead to issued patents; |
| ● | issued patents that we own or license may be held invalid
or unenforceable as a result of legal challenges by our competitors or others; |
| ● | our competitors might conduct R&D activities in countries where we do not have patent rights and
then use the information learned from such activities to develop competitive products for sale in our major commercial markets; |
| ● | any patents that we obtain, or are licensed to us, may not
provide us with any competitive advantages or protection against competitors, or may be challenged by third parties; |
| ● | we cannot predict the scope of protection of any patent issuing
based on our patent applications, including whether the patent applications that we own or may in-license in the future will result in
issued patents with claims that cover our product candidates or uses thereof in the United States or in other foreign countries; |
| ● | if we attempt to enforce our patents, a court may hold that
our patents are not invalid, unenforceable or not infringed; |
| ● | we may not develop additional proprietary technologies that
are patentable; |
| ● | we may need to initiate litigation or administrative proceedings
to enforce and/or defend our patent rights which will be costly whether we win or lose; |
| ● | we may choose not to file a patent in order to maintain certain
trade secrets or know-how, and a third party may subsequently file a patent covering such intellectual property; |
| ● | we may be required to change, redesign or stop using trademarks,
service marks, domain names, logos, trade names and other identifiers that we own or use to avoid infringing the rights of third parties; |
| ● | we may fail to adequately protect and police our trade secrets;
or |
| ● | the patents of others may have an adverse effect on our business,
including if others obtain patents claiming subject matter similar to or improving that covered by our patents and patent applications. |
Should any of these events occur, they could significantly
harm our business, results of operations and prospects.
Without patent protection
on the composition of matter of our product candidates, our ability to assert our patents to stop others from using or selling our product
candidates in a non-pharmaceutically acceptable formulation may be limited.
Due to the patent laws of
a country, or the decisions of a patent examiner in a country, or our own filing strategies, we may not obtain patent coverage for all
of our product candidates or methods involving these candidates in parent patent applications. We may have to pursue divisional patent
applications or continuation patent applications in the United States and other countries to obtain claim coverage for inventions
which were disclosed but not claimed in parent patent applications.
Moreover, it is possible
that our pending patent applications will not result in granted patents, and even if such pending patent applications are granted as patents,
they may not provide a basis for intellectual property protection of commercially viable products nor provide us with any competitive
advantages. Further, it is possible that, for any of the patents that may be granted in the future, others will design around the patent
rights or identify cancer treatment methods that do not concern the rights covered by our patent rights or licenses. Further, we cannot
assure investors that other parties will not challenge any patents granted to us or that courts or regulatory agencies will hold our patents
to be valid or enforceable. We also cannot guarantee that we will be successful in defending challenges made against our patents. Any
successful third-party challenge to our patents could result in the unenforceability or invalidity of such patents, or to such patents
being interpreted narrowly or otherwise in a manner adverse to our interests. Our ability to establish or maintain a technological or
competitive advantage over our competitors may be diminished because of these uncertainties.
We may also rely on trade
secrets to protect our technology, especially where we do not believe patent protection is appropriate or feasible. However, trade secrets
are difficult to protect. Although we use reasonable efforts to protect our trade secrets, our employees, consultants, contractors, outside
scientific collaborators and other advisors may unintentionally or willfully disclose our information to competitors or other third parties.
Enforcing a claim that a third party illegally obtained and is using any of our trade secrets may be expensive and time consuming, and
the outcome is unpredictable. In addition, courts outside the United States are sometimes less willing to protect trade secrets.
Moreover, our competitors may independently develop equivalent knowledge, methods and know-how.
If we are unable to obtain and maintain
patent protection for any products we develop and for our technology, or if the scope of the patent protection obtained is not sufficiently
broad, our competitors could develop and commercialize products and technology similar or identical to ours, and our ability to commercialize
any product candidates we may develop and our technology may be adversely affected.
Our success depends in large
part on our ability to obtain and maintain patent protection in the United States and other countries with respect to our product
candidates, their respective components, formulations, combination therapies, methods used to manufacture them and methods of treatment
and development that are important to our business. If we do not adequately protect our intellectual property rights, competitors may
be able to erode or negate any competitive advantage we may have, which could harm our business and ability to achieve profitability.
To protect our proprietary position, we file patent applications in the United States and abroad related to our product candidates
that are important to our business; we may in the future also license or purchase patent applications filed by others. If we are unable
to secure or maintain patent protection with respect to our technology and any proprietary products and technology we develop, our business,
financial condition, results of operations and prospects could be materially harmed.
We cannot provide any assurances
that any of our current or future patents have or will include claims with a scope sufficient to protect our current and future product
candidates or otherwise provide any competitive advantage. In addition, the laws of foreign countries may not protect our rights to the
same extent as the laws of the United States. Furthermore, patents have a limited lifespan. In the United States, the natural
expiration of a patent is generally 20 years after its earliest U.S. non-provisional filing date. Various extensions may be
available; however, the life of a patent, and the protection it affords, is limited. Given the amount of time required for the development,
testing and regulatory review of new product candidates, patents protecting such candidates might expire before or shortly after such
candidates are commercialized. As a result, our intellectual property may not provide us with sufficient rights to exclude others from
commercializing products similar or identical to ours. Moreover, some of our patents and patent applications are, and may in the future
be, owned by or co-owned with third parties. Any of the foregoing could have a material adverse effect on our competitive position, business,
financial conditions, results of operations and prospects.
The patent prosecution
process is complex, expensive, time-consuming and inconsistent across jurisdictions. We may not be able to file, prosecute,
maintain, enforce, or license all necessary or desirable patent rights at a commercially reasonable cost or in a timely manner. In
addition, we may not pursue or obtain patent protection in all relevant markets. It is possible that we will fail to identify
important patentable aspects of our R&D efforts in time to obtain any patent protection. While we enter into non-disclosure and
confidentiality agreements with parties who have access to confidential or patentable aspects of our R&D efforts, including for example, our employees, former employees, corporate collaborators, external academic scientific
collaborators, CROs, contract manufacturers, consultants, advisors and other third parties, any of these parties may breach the
agreements and disclose such output before a patent application is filed, thereby endangering our ability to seek patent protection.
In addition, publications of discoveries in the scientific and scholarly literature often lag behind the actual discoveries, and
patent applications in the United States and other jurisdictions are typically not published until 18 months after filing,
or in some cases not at all. Consequently, we cannot be certain that we were the first to file for patent protection on the
inventions claimed in our patents or pending patent applications.
The issuance or grant of
a patent is not irrefutable as to its inventorship, scope, validity or enforceability, and our patents may be challenged in the courts
or patent offices in the United States and abroad. There may be prior art of which we are not aware that may affect the validity
or enforceability of a patent claim. There also may be prior art of which we are aware, but which we do not believe affects the validity
or enforceability of a claim, which may, nonetheless, ultimately be found to affect the validity or enforceability of a claim. We may
in the future, become subject to a third-party pre-issuance submission of prior art or opposition, derivation, revocation, re-examination,
post-grant or inter partes review, or interference proceedings or other similar proceedings challenging our patent rights or the
patent rights of others in the USPTO or other foreign patent office. An unfavorable determination in any such submission, proceeding or
litigation could reduce the scope of or invalidate our patent rights, allow third parties to commercialize our technology or products
and compete directly with us, without payment to us, or extinguish our ability to manufacture or commercialize products without infringing
third-party patent rights.
Third-party claims of intellectual property
infringement may prevent or delay our product discovery and development efforts, and could increase our costs.
Our commercial success depends
in part on our avoiding infringement of the patents and proprietary rights of third parties. There is a substantial amount of litigation
involving patents and other intellectual property rights in the biotechnology and pharmaceutical industries, as well as administrative
proceedings for challenging patents, including interference, reexamination, and post grant review proceedings before the USPTO or oppositions
and other comparable proceedings in foreign jurisdictions. We may be exposed to, or threatened with, future litigation by third parties
having patent or other intellectual property rights alleging that our product candidates and/or proprietary technologies infringe their
intellectual property rights. Numerous U.S. and foreign issued patents and pending patent applications, which are owned by third
parties, exist in the fields in which we are developing our product candidates. As the biotechnology and pharmaceutical industries expand
and more patents are issued, the risk increases that our product candidates may give rise to claims of infringement of the patent rights
of others. Moreover, it is not always clear to industry participants, including us, which patents cover various types of drugs, products
or their methods of use or manufacture. Thus, because of the large number of patents issued and patent applications filed in our fields,
there may be a risk that third parties allege they have patent rights encompassing our product candidates, technologies or methods.
Third parties may assert
that we are employing their proprietary technology without authorization. Generally, conducting preclinical and clinical trials and other
development activities in the United States is not considered an act of infringement. If CER-1236 or another product candidate is
cleared/approved by the FDA, a third party may then seek to enforce its patent by filing a patent infringement lawsuit against us. While
we do not believe that any patent claims that could have a materially adverse effect on the commercialization of our product candidates
are valid and enforceable, we may be incorrect in this belief, or we may not be able to prove it in litigation. In this regard, patents
issued in the United States by law enjoy a presumption of validity that can be rebutted only with evidence that is “clear and
convincing,” a heightened standard of proof. There may be issued third-party patents of which we are currently unaware with claims
to compositions, formulations, methods of manufacture or methods for treatment related to the use or manufacture of our product candidates.
Patent applications can take many years to issue. There may be currently pending patent applications which may later result in issued
patents that our product candidates may infringe. In addition, third parties may obtain patents in the future and claim that use of our
technologies infringes upon these patents. Moreover, we may fail to identify relevant patents or incorrectly conclude that a patent is
invalid, not enforceable, exhausted, or not infringed by our activities. If any third-party patents were held by a court of competent
jurisdiction to cover the manufacturing process of our product candidates, constructs or molecules used in or formed during the manufacturing
process, or any final product itself, the holders of any such patents may be able to block our ability to commercialize the product candidate
unless we were to obtain a license under the applicable patents, or until such patents expire or they are finally determined to be held
invalid or unenforceable. Similarly, if any third-party patent were held by a court of competent jurisdiction to cover aspects of our
formulations, processes for manufacture or methods of use, the holders of any such patent may be able to block our ability to develop
and commercialize the product candidate unless we were to obtain a license or until such patent expires or is finally determined to be
held invalid or unenforceable. In either case, such a license may not be available on commercially reasonable terms or at all. If we are
unable to obtain a necessary license to a third-party patent on commercially reasonable terms, or at all, our ability to commercialize
our product candidates may be impaired or delayed, which could in turn significantly harm our business. Even if we obtain a license, it
may be non-exclusive, thereby giving our competitors access to the same technologies licensed to us. In addition, if the breadth or strength
of protection provided by our patents is threatened, it could dissuade companies from collaborating with us to license, develop or commercialize
current or future product candidates.
Parties making claims against
us may seek and obtain injunctive or other equitable relief, which could effectively block our ability to further develop and commercialize
our product candidates. Defense of these claims, regardless of their merit, could involve substantial litigation expense and would be
a substantial diversion of employee resources from our business. In the event of a successful claim of infringement against us, we may
have to pay substantial damages, including treble damages and attorneys’ fees for willful infringement, obtain one or more licenses
from third parties, pay royalties or redesign our infringing products, which may be impossible or require substantial time and monetary
expenditure. We cannot predict whether any such license would be available at all or whether it would be available on commercially reasonable
terms. Furthermore, even in the absence of litigation, we may need or may choose to obtain licenses from third parties to advance our
research or allow commercialization of our product candidates. We may fail to obtain any of these licenses at a reasonable cost or on
reasonable terms, if at all. In that event, we would be unable to further develop and commercialize our product candidates, which could
harm our business significantly.
We could be found liable
for monetary damages, including treble damages and attorneys’ fees, if we are found to have willfully infringed a patent of a third
party. A finding of infringement could prevent us from commercializing our product candidates or any future product candidates or force
us to cease some of our business operations, which could materially harm our business.
Although we have reviewed
certain third-party patents and patent filings that we believe may be relevant to our therapeutic candidates or products, we have not
conducted a freedom-to-operate search or analysis for any of our therapeutic candidates or products, and we may not be aware of patents
or pending or future patent applications that, if issued, would block us from commercializing our therapeutic candidates or products.
Thus, we cannot guarantee that our therapeutic candidates or products, or our commercialization thereof, do not and will not infringe
any third party’s intellectual property.
We may not be successful in obtaining or
maintaining necessary rights to product components and processes for our manufacturing and development pipeline through acquisitions and
in-licenses.
Presently, we have rights
to certain intellectual property, under issued patents that we own, including U.S. Patent No. 11,655,282 and EP Patent No. 3,519,441,
which relate to CER-1236, as well as additional patents which relate to certain other product candidates. U.S. Patent Application Number
17/400,082 was allowed and later issued on May 23, 2023 as U.S. Patent Number 11,655,282. This patent provides coverage over our
CER-1236 product candidate and includes claims directed to a CER comprising, at least in part, Tim-4, a phosphatidylserine binding domain,
its sequence, and various Tim-4 proteins. Because additional product candidates may require the use of proprietary rights held by third
parties, the growth of our business will likely depend in part on our ability to acquire, in-license or use these proprietary rights.
In addition, while we have patent rights directed to certain T cell constructs, we may not be able to obtain intellectual property rights
to broader T cell or engineered T cell constructs.
Our product candidates may
also require specific formulations to work effectively and efficiently and these rights may be held by others. Similarly, efficient production
or delivery of our product candidates may also require specific compositions or methods, and the rights to these may be owned by third
parties. We may be unable to acquire or in-license any compositions, methods of use, processes or other third-party intellectual property
rights from third parties that we identify as necessary or important to our business operations. We may fail to obtain any of these licenses
at a reasonable cost or on reasonable terms, if at all, which would harm our business. We may need to cease use of the compositions or
methods covered by such third-party intellectual property rights, and may need to seek to develop alternative approaches that do not infringe
on such intellectual property rights which may entail additional costs and development delays, even if we were able to develop such alternatives,
which may not be feasible. Even if we are able to obtain a license, it may be non-exclusive, thereby giving our competitors access to
the same technologies licensed to us. In that event, we may be required to expend significant time and resources to develop or license
replacement technology. Moreover, the specific antibodies that will be used with our product candidates may be covered by the intellectual
property rights of others.
Additionally, we may collaborate
with academic institutions to accelerate our preclinical research or development under written agreements with these institutions. In
certain cases, these institutions may provide us with an option to negotiate a license to any of the institution’s rights in technology
resulting from the collaboration. Regardless of such option, we may be unable to negotiate a license within the specified timeframe or
under terms that are acceptable to us. If we are unable to do so, the institution may offer the intellectual property rights to others,
potentially blocking our ability to pursue our program. If we are unable to successfully obtain rights to required third-party intellectual
property or to maintain the existing intellectual property rights we have, we may have to abandon development of such program and our
business and financial condition could suffer.
The licensing and acquisition
of third-party intellectual property rights is a competitive area, and companies which may be more established, or have greater resources
than we do, may also be pursuing strategies to license or acquire third-party intellectual property rights that we may consider necessary
or attractive in order to commercialize our product candidates. More established companies may have a competitive advantage over us due
to their size, cash resources and greater clinical development and commercialization capabilities.
We may be involved in lawsuits to protect
or enforce our patents which could be expensive, time-consuming and unsuccessful.
Competitors may infringe
our patents. To counter infringement or unauthorized use, we may be required to file infringement claims, which can be expensive and time-consuming.
In addition, in a legal proceeding, a court may decide that one or more of our patents is not valid or is unenforceable or may refuse
to stop the other party from using the technology at issue on the grounds that our patents do not cover the technology in question. An
adverse result in any litigation or defense proceedings could put one or more of our patents at risk of being invalidated, held unenforceable
or interpreted narrowly and could put one or more of our pending patent applications at risk of not issuing. Defense of these claims,
regardless of their merit, would involve substantial litigation expense and would be a substantial diversion of employee resources from
our business. In the event of a successful claim of infringement against us, we may have to pay substantial damages, including treble
damages and attorneys’ fees for willful infringement, obtain one or more licenses from third parties, pay royalties or redesign
our infringing products, which may be impossible or require substantial time and monetary expenditure.
Interference or derivation
proceedings provoked by third parties or brought by the USPTO may be necessary to determine the priority or provenance of inventions with
respect to our patents or patent applications or those of our prospective licensors. An unfavorable outcome could result in a loss of
our current patent rights and could require us to cease using the related technology or to attempt to license rights to it from the prevailing
party. Our business could be harmed if the prevailing party does not offer us a license on commercially reasonable terms. Litigation or
interference or derivation proceedings may result in a decision adverse to our interests and, even if we are successful, may result in
substantial costs and distract our management and other employees. We may not be able to prevent, alone or with our licensors, misappropriation
of our trade secrets or confidential information, particularly in countries where the laws may not protect those rights as fully as in
the United States.
Furthermore, because of the
substantial amount of discovery required in connection with intellectual property litigation, there is a risk that some of our confidential
information could be compromised by disclosure during this type of litigation. In addition, there could be public announcements of the
results of hearings, motions or other interim proceedings or developments. If securities analysts or investors perceive these results
to be negative, it could have a substantial adverse effect on the price of our Common Stock.
Obtaining and maintaining our patent protection
depends on compliance with various procedural, document submission, fee payment and other requirements imposed by governmental patent
agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.
Periodic maintenance and
annuity fees on any issued patent are due to be paid to the USPTO and patent agencies outside the United States in several stages
over the lifetime of the patent. The USPTO and various foreign governmental patent agencies require compliance with a number of procedural,
documentary, fee payment and other similar provisions during the patent application process. While an inadvertent lapse can in many cases
be cured by payment of a late fee or by other means in accordance with the applicable rules, there are situations in which noncompliance
can result in abandonment or lapse of the patent, resulting in partial or complete loss of patent rights in the relevant jurisdiction.
Non-compliance events that could result in abandonment or lapse of a patent include failure to respond to official actions within prescribed
time limits, non-payment of fees and failure to properly legalize and submit formal documents. If we fail to maintain the patents covering
our product candidates, our competitors might be able to enter the market, which would harm our business. In addition, to the extent that
we have responsibility for taking any action related to the prosecution or maintenance of patents or patent application in-licensed from
a third party, any failure on our part to maintain the in-licensed rights could jeopardize our rights under the relevant license and may
expose us to liability.
We may be subject to claims challenging
the inventorship of our patents and other intellectual property.
We may in the future be subject
to claims that former employees, collaborators, or other third parties have an interest in our patents or other intellectual property
as an inventor or co-inventor. For example, we may have inventorship disputes arise from conflicting obligations of consultants or others
who are involved in developing our product candidates. Litigation may be necessary to defend against these and other claims challenging
inventorship. If we fail in defending any such claims, in addition to paying monetary damages, we may lose valuable intellectual property
rights, such as exclusive ownership of, or right to use, valuable intellectual property. Such an outcome could have a material adverse
effect on our business. Even if we are successful in defending against such claims, litigation could result in substantial costs and be
a distraction to management and other employees.
We may need to license intellectual property
from third parties, and such licenses may not be available or may not be available on commercially reasonable terms.
A third party may hold intellectual
property rights, including patent rights, that are important or necessary to the development or manufacture of our product candidates.
It may be necessary for us to use the patented or proprietary technology of third parties to commercialize our product candidates, in
which case we would be required to obtain a license from these third parties. Such a license may not be available on commercially reasonable
terms, or at all, and we could be forced to accept unfavorable contractual terms. If we are unable to obtain such licenses on commercially
reasonable terms, our business could be harmed.
Issued patents covering our product candidates
could be found unpatentable, invalid or unenforceable if challenged in court or the USPTO.
If we initiate legal proceedings
against a third party to enforce a patent covering one of our product candidates, the defendant could counterclaim that the patent covering
our product candidate, as applicable, is invalid and/or unenforceable. In patent litigation in the United States, defendant counterclaims
alleging invalidity and/or unenforceability are commonplace, and there are numerous grounds upon which a third party can assert invalidity
or unenforceability of a patent. Third parties may also raise similar claims before administrative bodies in the United States or
abroad, even outside the context of litigation. Such mechanisms include inter partes review, ex parte re-examination and
post grant review in the United States, and equivalent proceedings in foreign jurisdictions (e.g., opposition proceedings).
Such proceedings could result in revocation or amendment to our patents in such a way that they no longer cover and protect our product
candidates. The outcome following legal assertions of unpatentability, invalidity and unenforceability is unpredictable. With respect
to the validity question, for example, we cannot be certain that there is no invalidating prior art, of which we, our patent counsel and
the patent examiner were unaware during prosecution. If a defendant were to prevail on a legal assertion of unpatentability, invalidity
and/or unenforceability, we would lose at least part, and perhaps all, of the patent protection on our product candidates. Such a loss
of patent protection could have a material adverse impact on our business.
Changes to patent law in the United States
and in foreign jurisdictions could diminish the value of patents in general, thereby impairing our ability to protect our products.
As is the case with other
biopharmaceutical companies, our success is heavily dependent on intellectual property, particularly patents. Obtaining and enforcing
patents in the biopharmaceutical industry involve both technological and legal complexity, and is therefore costly, time-consuming and
inherently uncertain. In addition, the United States continues to adapt to wide-ranging patent reform legislation, including legislation
that became effective starting in 2012. Moreover, recent U.S. Supreme Court rulings have narrowed the scope of patent protection
available in certain circumstances and weakened the rights of patent owners in certain situations. In addition to increasing uncertainty
with regard to our ability to obtain patents in the future, this combination of events has created uncertainty with respect to the value
of patents, once obtained. Depending on decisions by the U.S. Congress, the federal courts, and the USPTO, the laws and regulations
governing patents could change in unpredictable ways that would weaken our ability to obtain new patents or to enforce our existing patents
and patents that we might obtain in the future. For example, in the case Assoc. for Molecular Pathology v. Myriad Genetics, Inc.,
the U.S. Supreme Court held that certain claims to DNA molecules are not patentable. While we do not believe that any of the patents
owned by us will be found invalid based on this decision, we cannot predict how future decisions by the courts, Congress or the USPTO
may impact the value of our patents. Similarly, any adverse changes in the patent laws of other jurisdictions could have a material adverse
effect on our business and financial condition. Changes in the laws and regulations governing patents in other jurisdictions could similarly
have an adverse effect on our ability to obtain and effectively enforce our patent rights.
We may not be able to protect our intellectual
property rights throughout the world.
We may not be able to protect
our intellectual property rights outside the United States. Filing, prosecuting and defending patents on product candidates in all
countries throughout the world would be prohibitively expensive, and our intellectual property rights in some countries outside the United States
can be less extensive than those in the United States. In addition, the laws of some foreign countries do not protect intellectual
property rights to the same extent as federal and state laws in the United States. Consequently, we may not be able to prevent third
parties from practicing our inventions in all countries outside the United States, or from selling or importing products made using
our inventions in other jurisdictions. Competitors may use our technologies in jurisdictions where we have not obtained patent protection
to develop their own products and further, may export otherwise infringing products to territories where we have patent protection, but
enforcement is not as strong as that in the United States. These products may compete with our products and our patents or other
intellectual property rights may not be effective or sufficient to prevent them from competing.
Many companies have encountered
significant problems in protecting and defending intellectual property rights in foreign jurisdictions. The legal systems of certain countries
which we could expand to, particularly certain developing countries, do not favor the enforcement of patents, trade secrets and other
intellectual property protection, particularly those relating to biopharmaceutical products, which could make it difficult for us to stop
the infringement of our patents or marketing of competing products in violation of our proprietary rights generally. Proceedings to enforce
our patent rights in foreign jurisdictions could result in substantial costs and divert our efforts and attention from other aspects of
our business, could put our patents at risk of being invalidated or interpreted narrowly and our patent applications at risk of not issuing
and could provoke third parties to assert claims against us. We may not prevail in any lawsuits that we initiate and the damages or other
remedies awarded, if any, may not be commercially meaningful. Accordingly, our efforts to enforce our intellectual property rights around
the world may be inadequate to obtain a significant commercial advantage from the intellectual property that we develop or license.
We may be subject to claims that our employees,
consultants or independent contractors have wrongfully used or disclosed confidential information of third parties.
We have received confidential
and proprietary information from third parties. In addition, we employ individuals who were previously employed at other biotechnology
or pharmaceutical companies. We may be subject to claims that we or our employees, consultants or independent contractors have inadvertently
or otherwise used or disclosed confidential information of these third parties or our employees’ former employers. Litigation may
be necessary to defend against these claims. Even if we are successful in defending against these claims, litigation could result in substantial
cost and be a distraction to our management and employees.
If we are unable to protect the confidentiality
of our trade secrets, our business and competitive position would be harmed.
In addition to seeking patent
protection for our product candidates, we also rely on trade secrets, including unpatented know-how, technology and other proprietary
information, to maintain our competitive position. We seek to protect our trade secrets, in part, by entering into non-disclosure and
confidentiality agreements with parties who have access to them, such as our employees, consultants, advisors and other third parties.
We also enter into confidentiality and invention or patent assignment agreements with our employees and consultants. Despite these efforts,
any of these parties may breach the agreements and disclose our proprietary information, including our trade secrets. Monitoring unauthorized
uses and disclosures of our intellectual property is difficult, and we do not know whether the steps we have taken to protect our intellectual
property will be effective. In addition, we may not be able to obtain adequate remedies for any such breaches. Enforcing a claim that
a party illegally disclosed or misappropriated a trade secret is difficult, expensive and time-consuming, and the outcome is unpredictable.
In addition, some courts inside and outside the United States are less willing or unwilling to protect trade secrets.
Moreover, our competitors
may independently develop knowledge, methods and know-how equivalent to our trade secrets. Competitors could purchase our products and
replicate some or all of the competitive advantages we derive from our development efforts for technologies on which we do not have patent
protection. If any of our trade secrets were to be lawfully obtained or independently developed by a competitor, we would have no right
to prevent them, or those to whom they communicate it, from using that technology or information to compete with us. If any of our trade
secrets were to be disclosed to or independently developed by a competitor, our competitive position would be harmed.
Our reliance on third parties requires us
to share our trade secrets, which increases the possibility that a competitor will discover them or that our trade secrets will be misappropriated
or disclosed.
Because we will rely on third
parties to research and develop and to manufacture our product candidates, we must share trade secrets with them. We seek to protect our
proprietary technology in part by entering into confidentiality agreements and, if applicable, material transfer agreements, consulting
agreements or other similar agreements with our advisors, employees, third-party contractors and consultants prior to beginning research
or disclosing proprietary information. These agreements typically limit the rights of the third parties to use and disclose our confidential
information, including our trade secrets. Despite the contractual provisions employed when working with third parties, the need to share
trade secrets and other confidential information increases the risk that such trade secrets become known by our competitors, are inadvertently
incorporated into the technology of others, or are disclosed or used in violation of these agreements. Given that our proprietary position
is based, in part, on our know-how and trade secrets, a competitor’s independent discovery of our trade secrets or other unauthorized
use or disclosure would impair our competitive position and may have a material adverse effect on our business.
In addition, these
agreements typically restrict the ability of our advisors, employees, third-party contractors and consultants to publish data
potentially relating to our trade secrets, although our agreements may contain certain limited publication rights. For example, any
academic institution that we may collaborate with will likely expect to be granted rights to publish data arising out of such
collaboration and any joint R&D programs may require us to share trade secrets under the terms of our R&D or similar
agreements. Despite our efforts to protect our trade secrets, our competitors may discover our trade secrets, either through breach
of our agreements with third parties, independent development or publication of information by any of our third-party collaborators.
A competitor’s discovery of our trade secrets would impair our competitive position and have an adverse impact on our
business.
We may not have sufficient patent lifespan
to effectively protect our products and business.
All of our patents are in
early stages. Patents have a limited lifespan. In the United States, the natural expiration of a patent is generally 20 years
after its earliest U.S. non-provisional filing date. Given the amount of time required for the development, testing and regulatory
review of new product candidates, patents protecting such candidates might expire before or shortly after the resulting products are commercialized.
As a result, our patents may not provide us with sufficient rights to exclude others from commercializing products similar or identical
to ours. We expect to seek extensions of patent terms for our issued patents, where available. This includes in the United States
under the Hatch-Waxman Act, which permits a patent term extension of up to five years beyond the original expiration date of the
patent as compensation for regulatory delays. However, such a patent term extension cannot lengthen the remaining term of a patent beyond
a total of 14 years from the product’s approval date. Only one patent applicable to an approved drug is eligible for the extension
and the application for the extension must be submitted prior to the expiration of the patent. During the period of patent term extension,
the claims of a patent are not enforceable for their full scope but are instead limited to the scope of the approved product. In addition,
the applicable authorities, including the FDA in the United States, and any comparable foreign regulatory authorities, may not agree
with our assessment of whether such extensions are available, and may refuse to grant extensions to our patents, or may grant more limited
extensions than we request. In addition, we may not be granted an extension because of, for example, failing to apply within applicable
deadlines, failing to apply prior to the expiration of relevant patents or otherwise failing to satisfy applicable requirements. The terms
of our patents may also be affected by the filing of terminal disclaimers during prosecution before the USPTO and foreign authorities
recognizing similar disclaimer mechanisms. A patent subject to a terminal disclaimer may have its term limited so that its lifespan does
not extend beyond the term of a related patent having a shorter term. If any of the foregoing occurs, any period during which we have
the right to exclusively market our product will be shorter than we would otherwise have expected, and our competitors may obtain approval
of and launch products earlier than might otherwise have been the case.
The life of patent protection is limited,
and third parties could develop and commercialize products and technologies similar or identical to ours and compete directly with us
after a patent licensed to us expires, which could materially and adversely affect our ability to commercialize our products and technologies.
The life of a patent and
the protection it affords is limited. For example, in the United States, if all maintenance fees are timely paid, the natural expiration
of a patent is generally 20 years from its earliest U.S. non-provisional filing date. In Europe, the expiration of an invention
patent is 20 years from its filing date. Even if we successfully obtain patent protection for an approved product candidate, it may
face competition from biosimilar medications. Manufacturers of other drugs may challenge the scope, validity or enforceability of the
patents underlying our technology in court or before a patent office, and the patent holder may not be successful in enforcing or defending
those intellectual property rights and, as a result, we may not be able to develop or market the relevant product candidate exclusively,
which would materially adversely affect any potential sales of that product.
Given the amount of time
required for the development, testing and regulatory review of new product candidates, patents protecting such product candidates might
expire before or shortly after such product candidates are commercialized. As a result, the patents or pending applications licensed to
us may not provide us with sufficient rights to exclude others from commercializing products similar or identical to ours. Even if we
believe that the patents involved are eligible for certain (and time-limited) patent term extensions, there can be no assurance that the
applicable authorities, including the FDA and the USPTO, and any equivalent regulatory authority in other countries, will agree with our
assessment of whether such extensions are available, and such authorities may refuse to grant extensions to such patents, or may grant
more limited extensions than requested. Moreover, the applicable time period or the scope of patent protection afforded could be less
than requested. If we are unable to obtain patent term extension or term of any such extension is less than requested, our competitors
may obtain approval of competing products following our patent expiration, and our business could be harmed. Changes in either the patent
laws or interpretation of the patent laws in the United States and other countries may diminish the value of our patents or narrow
the scope of our patent protection.
The patent pending applications
for our product candidates are expected to expire on various dates. Upon the expiration, we will not be able to assert such licensed patent
rights against potential competitors, which would materially adversely affect our business, financial condition, results of operations
and prospects.
Risks Related to Ownership of our Securities
An active trading market for our Common
Stock may not be available on a consistent basis to provide stockholders with adequate liquidity. The price of our Common Stock may be
extremely volatile, and stockholders could lose all or part of their investment.
The trading price of our
Common Stock is likely to be highly volatile and could be subject to wide fluctuations in response to various factors, some of which are
beyond our control, including limited trading volume. In addition to the factors discussed in this “Risk Factors” section
and elsewhere in this Annual Report, these factors include:
| ● | the commencement, enrollment or results of any planned and
future preclinical studies and clinical trials of our product candidates or changes in the development status of our product candidates; |
| ● | any delay in our regulatory filings for our product candidates
and any adverse development or perceived adverse development with respect to the applicable regulatory authority’s review of such
filings; |
| ● | adverse results from or delays in preclinical studies and
clinical trials of our product candidates, including as a result of clinical holds, safety events, enrollment difficulties, or study
protocol amendments; |
| ● | Our decision to initiate a clinical trial, not to initiate
a clinical trial or to terminate an existing clinical trial; |
| ● | adverse regulatory decisions, including failure to receive
regulatory approval of our drug to market for our product candidates; |
| ● | adverse developments concerning our manufacturers; |
| ● | Our inability to obtain adequate product supply for any approved
drug or inability to do so at acceptable prices; |
| ● | Our inability to establish collaborations, if needed; |
| ● | Our failure to commercialize our product candidates; |
| ● | additions or departures of key scientific or management personnel; |
| ● | unanticipated serious safety concerns related to the use
of our product candidates; |
| ● | introduction of new drugs by our competitors; |
| ● | announcements of significant acquisitions, strategic partnerships,
joint ventures or capital commitments by us or our competitors; |
| ● | any significant change in our management; |
| ● | Our ability to effectively manage our growth; |
| ● | the size and growth of our initial target markets; |
| ● | actual or anticipated variations in quarterly operating results; |
| ● | Our failure to meet the estimates and projections of the
investment community or that we may otherwise provide to the public; |
| ● | the public’s response to press releases or other public
announcements by us or third parties, including our filings with the SEC; |
| ● | publication of research reports about us or our industry,
or microbiome therapies in particular, or positive or negative recommendations or withdrawal of research coverage by securities analysts; |
| ● | guidance, if any, that we provide to the public, any changes
in this guidance or our failure to meet this guidance; |
| ● | changes in the market valuations of similar companies; |
| ● | overall performance of the equity markets; |
| ● | sales of our Common Stock by us or our stockholders, in the
future; |
| ● | sales of our Common Stock by certain stockholders pursuant
to, and following the termination or expiry of the applicable lock-up period pursuant to the Investor Rights Agreement, the Existing
Lock-Ups, or any similar agreement restricting our securityholders’ ability to sell our Common Stock; |
| ● | trading volume of our Common Stock; |
| ● | investor perceptions of the investment opportunity associated
with our Common Stock relative to other investment alternatives; |
| ● | actions by institutional or activist stockholders; |
| ● | change in accounting standards, policies, guidelines, interpretations
or principles; |
| ● | ineffectiveness of our internal controls; |
| ● | disputes or other developments relating to proprietary rights,
including patents, litigation matters and our ability to obtain patent protection for our technologies; |
| ● | significant lawsuits, including patent or stockholder litigation; |
| ● | changes in the structure of healthcare payments systems; |
| ● | issuance of additional shares of our Common Stock to comply
with the full ratchet antidilution rights contained in our outstanding Warrants; |
| ● | failure to raise additional funds on acceptable terms, or
at all; |
| ● | changes in business or regulatory conditions, including new
laws or regulations or new interpretations of existing laws or regulations applicable to our business; |
| ● | general political, economic, industry and market conditions,
including rising interest rates and inflation; and |
| ● | other events or factors, many of which are beyond our control. |
In addition, the stock market
in general, and the markets for special purpose acquisition company (“SPAC”) post-business combination businesses and healthcare companies in particular, have experienced extreme
price and volume fluctuations that have often been unrelated or disproportionate to the operating performance of these companies. Broad
market and industry factors may negatively affect the market price of our Common Stock, regardless of our actual operating performance.
In addition, price volatility may be greater if the public float and trading volume of our Common Stock is low. If the market price of
our Common Stock falls, you may not realize any return on your investment and may lose some or all of your investment. In the past, securities
class action litigation has often been instituted against companies following periods of volatility in the market price of a company’s
securities. This type of litigation, if instituted, could result in substantial costs and a diversion of management’s attention
and resources, which would harm our business, operating results or financial condition.
Unstable market and economic conditions
may have serious adverse consequences on our business, financial condition and stock price.
The global economy, including
credit and financial markets, has experienced extreme volatility and disruptions, including severely diminished liquidity and credit availability,
declines in consumer confidence, declines in economic growth, increases in unemployment rates, increases in inflation rates, higher interest
rates and uncertainty about economic stability. For example, the Russia-Ukraine war and the Israel-Hamas war created volatility in the
global capital markets and may have further global economic consequences, including disruptions of the global supply chain and energy
markets. There have also been disruptions to the U.S. banking system due to bank failures in the past several years, including with
respect to Silicon Valley Bank, Signature Bank and First Republic Bank. Any such volatility and disruptions may have adverse consequences
on us or the third parties on whom it relies. If the equity and credit markets deteriorate, including as a result of political unrest
or war, it may make any necessary debt or equity financing more difficult to obtain in a timely manner or on favorable terms, more costly
or more dilutive. Increased inflation rates can adversely affect us by increasing its costs, including labor and employee benefit costs.
In addition, higher inflation could also increase customers’ operating costs, which could result in reduced budgets for customers
and potentially less demand for our products, if and when approved. Any significant increases in inflation and related increase in interest
rates could have a material adverse effect on our business, results of operations and financial condition.
We do not intend to pay dividends on our
Common Stock, so any returns will be limited to the value of its stock.
We currently anticipate that
we will retain future earnings for the development, operation and expansion of our business and do not anticipate declaring or paying
any cash dividends for the foreseeable future. In addition, future debt or other financing arrangements may contain terms prohibiting
or limiting the amount of dividends that may be declared or paid on our Common Stock. Any return to stockholders will therefore be limited
in the foreseeable future to the appreciation of the market price (if any) of our stock.
We are an “emerging growth company”
and a “smaller reporting company”, and the reduced reporting requirements applicable to emerging growth companies and smaller
reporting companies may make our Common Stock less attractive to investors.
We are an “emerging
growth company” within the meaning of the Securities Act, as modified by the JOBS Act. For as long as we continue to be an emerging
growth company, we may take advantage of certain exemptions from various public company reporting requirements that are applicable to
other public companies that are not emerging growth companies, including being permitted to provide only two years of audited financial
statements, in addition to any required unaudited interim financial statements with correspondingly reduced “Management’s
Discussion and Analysis of Financial Condition and Results of Operations” disclosure, not being required to have its internal control
over financial reporting audited by our independent registered public accounting firm under Section 404 of the Sarbanes-Oxley Act
(“Section 404”), reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements,
and exemptions from the requirements of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden
parachute payments not previously approved. We may take advantage of these exemptions until the last day of the fiscal year ending
after the fifth anniversary of the consummation of our IPO or until we are no longer an emerging growth company, whichever is earlier.
We will cease to be an emerging growth company prior to the end of such five-year period if certain earlier events occur, including if
we become a “large accelerated filer” as defined in Rule 12b-2 under the Exchange Act, our annual gross revenues
equal or exceed $1.235 billion or we issue more than $1.0 billion of non-convertible debt in any three-year period prior to
such time. In particular, in this Annual Report on, we have provided only two years of audited financial statements and have not
included all of the executive compensation related information that would be required if it were not an emerging growth company, and it
may elect to take advantage of other reduced reporting requirements in future filings. Accordingly, the information contained herein may
be different than the information you receive from other public companies in which you hold stock.
In addition, the JOBS Act
provides that an emerging growth company can take advantage of an extended transition period for complying with new or revised accounting
standards. We have elected to take advantage of the extended transition period to comply with new or revised accounting standards and
to adopt certain of the reduced disclosure requirements available to emerging growth companies. As a result of the accounting standards
election, we will not be subject to the same implementation timing for new or revised accounting standards as other public companies that
are not emerging growth companies, which may make comparison of its financials to those of other public companies more difficult. As a
result of these elections, the information that we provide in this Annual Report may be different than the information you may receive
from other public companies in which you hold equity interests. In addition, it is possible that some investors will find our Common Stock
less attractive as a result of these elections, which may result in a less active trading market for our Common Stock and higher volatility
in its share price.
We are also a “smaller
reporting company” as defined in the Exchange Act. We may continue to be a smaller reporting company even after we is no longer
an emerging growth company. We may take advantage of certain of the scaled disclosures available to smaller reporting companies and will
be able to take advantage of these scaled disclosures for so long as our Common Stock held by non-affiliates is less than $250.0 million
measured on the last business day of our second fiscal quarter, or our annual revenue is less than $100.0 million during the
most recently completed fiscal year and our Common Stock held by non-affiliates is less than $700.0 million measured on the last
business day of our second fiscal quarter.
Our operating results may fluctuate significantly,
which makes future operating results difficult to predict and could cause operating results to fall below expectations or guidance.
Our operations to date have
been primarily limited to researching and developing our product candidates. We have not yet obtained regulatory approvals for any of
its product candidates. Consequently, any predictions you make about our future success or viability may not be as accurate as they could
be if we had a longer operating history or approved products on the market.
Our quarterly and annual
operating results may fluctuate significantly in the future, which makes it difficult for us to predict future operating results. From
time to time, we may enter into license or collaboration agreements with other companies that include development funding and significant
upfront and milestone payments and/or royalties, which may become an important source of our revenue. Accordingly, our revenue may depend
on development funding and the achievement of development and clinical milestones under current and any potential future license and collaboration
agreements and sales of our drugs, if approved. These upfront and milestone payments may vary significantly from period to period and
any such variance could cause a significant fluctuation in operating results from one period to the next.
In addition, our measures
compensation cost for stock-based awards made to employees, directors and non-employee consultants based on the fair value of the award
on the grant date and we recognize the cost as an expense over the requisite service period, as applicable. Because the variables that
we uses as a basis for valuing stock-based awards change over time, including our underlying stock price and stock price volatility, the
magnitude of the expense that we must recognize may vary significantly.
Furthermore, operating results
may fluctuate due to a variety of other factors, many of which are outside of our control and may be difficult to predict, including the
following:
| ● | delays in the commencement, enrollment and the timing of
clinical testing for our product candidates; |
| ● | the timing and success or failure of clinical trials for
our product candidates or competing product candidates, or any other change in the competitive landscape of our industry, including consolidation
among our competitors or partners; |
| ● | any delays in regulatory review and approval of product candidates
in clinical development; |
| ● | the timing and cost of, and level of investment in, R&D activities relating to our product
candidates, which may change from time to time; |
| ● | the cost of manufacturing our product candidates, which may
vary depending on FDA guidelines and requirements, and the quantity of production; |
| ● | our ability to obtain additional funding to develop product
candidates; |
| ● | expenditures that our will or may incur to acquire or develop
additional product candidates and technologies; |
| ● | the level of demand for our product candidates, should they
receive approval, which may vary significantly; |
| ● | potential side effects of our product candidates that could
delay or prevent commercialization or cause an approved drug to be taken off the market; |
| ● | the ability of patients or healthcare providers to obtain
coverage of or sufficient reimbursement for our product candidates, if approved; |
| ● | Our dependency on third-party manufacturers to supply or
manufacture our product candidates; |
| ● | our ability to establish an effective sales, marketing and
distribution infrastructure in a timely manner; |
| ● | market acceptance of our product candidates, if approved,
and our ability to forecast demand for those product candidates; |
| ● | our ability to receive approval and commercialize product
candidates outside of the United States; |
| ● | Our ability to establish and maintain collaborations, licensing
or other arrangements; |
| ● | Our ability and third parties’ abilities to protect
intellectual property rights; |
| ● | costs related to and outcomes of potential litigation or
other disputes; |
| ● | Our ability to adequately support future growth; |
| ● | Our ability to attract and retain key personnel to manage
our business effectively; |
| ● | potential liabilities associated with hazardous materials; |
| ● | Our ability to maintain adequate insurance policies; and |
| ● | future accounting pronouncements or changes in our accounting
policies. |
The cumulative effect of
such factors could result in large fluctuations and unpredictability in quarterly and annual operating results. As a result, comparing
operating results on a period-to-period basis may not be meaningful. Investors should not rely on past results as an indication of future
performance. This variability and unpredictability could also result in our failing to meet the expectations of industry or financial
analysts or investors for any period. If our revenue or operating results fall below the expectations of analysts or investors or below
any forecasts we may provide to the market, or if the forecasts we provide to the market are below the expectations of analysts or investors,
the price of our Common Stock could decline substantially. Such a stock price decline could occur even when we have met any previously
publicly stated revenue and/or earnings guidance we may provide.
Anti-takeover provisions under our organizational
documents and Delaware law could delay or prevent a change of control which could limit the market price of our Common Stock and may
prevent or frustrate attempts by our stockholders to replace or remove our then-current management.
Our second amended and restated
certificate of incorporation (“Charter”), and second amended and restated bylaws (“Bylaws”), contain provisions
that could delay or prevent a change of control of our board of directors that our stockholders might consider favorable. Some of these
provisions include:
| ● | a board of directors divided into three classes serving staggered
three-year terms, such that not all members of the board of directors will be elected at one time; |
| ● | a prohibition on stockholder action through written consent,
which requires that all stockholder actions be taken at a meeting of our stockholders; |
| ● | a requirement that special meetings of stockholders be called
only by the chairperson of our board of directors, our Chief Executive Officer or by a majority of the total number of authorized directors; |
| ● | a requirement that no member of our board of directors may
be removed from office by our stockholders except for cause and, in addition to any other vote required by law and subject to the rights
of the holders of any series of preferred stock to elect additional directors under specified circumstances, upon the approval of not
less than two-thirds of all outstanding shares of our voting stock then entitled to vote in the election of directors; |
| ● | a requirement of approval of not less than two-thirds of
all outstanding shares of our voting stock to amend any bylaws by stockholder action or to amend specific provisions of our Charter;
and |
| ● | the authority of the board of directors to issue preferred
stock on terms determined by the board of directors without stockholder approval and which preferred stock may include rights superior
to the rights of the holders of Common Stock. |
In addition, because we are
incorporated in Delaware, we are governed by the provisions of Section 203 of the Delaware General Corporation Law (“DGCL”), which may prohibit certain business combinations
with stockholders owning 15% or more of our outstanding voting stock. These anti-takeover provisions and other provisions in our Charter
or Bylaws could make it more difficult for stockholders or potential acquirors to obtain control of our board of directors or initiate
actions that are opposed by the then-current board of directors and could also delay or impede a merger, tender offer, or proxy contest.
These provisions could also discourage proxy contests and make it more difficult for you and other stockholders to elect directors of
your choosing or cause us to take other corporate actions you desire. Any delay or prevention of a change of control transaction or changes
in our board of directors could cause the market price of our Common Stock to decline.
If we engage in future acquisitions or strategic
partnerships, this may increase capital requirements, dilute stockholders, cause us to incur debt or assume contingent liabilities, and
subject us to other risks.
We intend to evaluate various
acquisition opportunities and strategic partnerships, including licensing or acquiring complementary drugs, intellectual property rights,
technologies or businesses. Any potential acquisition or strategic partnership may entail numerous risks, including:
| ● | increased operating expenses and cash requirements; |
| ● | the assumption of additional indebtedness or contingent liabilities; |
| ● | the issuance of our equity securities; |
| ● | assimilation of operations, intellectual property and drugs
of an acquired company, including difficulties associated with integrating new personnel; |
| ● | the diversion of our management’s attention from our
existing drug programs and initiatives in pursuing such a strategic partnership, merger or acquisition; |
| ● | retention of key employees, the loss of key personnel and
uncertainties in our ability to maintain key business relationships; |
| ● | risks and uncertainties associated with the other party to
such a transaction, including the prospects of that party and their existing products or product candidates and marketing approvals;
and |
| ● | Our inability to generate revenue from acquired technology
and/or products sufficient to meet our objectives in undertaking the acquisition or even to offset the associated acquisition and maintenance
costs. |
In addition, if we undertake
acquisitions, we may issue dilutive securities, assume or incur debt obligations, incur large one-time expenses and acquire intangible
assets that could result in significant future amortization expense. Moreover, we may not be able to locate suitable acquisition opportunities,
and this inability could impair our ability to grow or obtain access to technology or products that may be important to the development
of our business.
Our Bylaws provide that the Court of Chancery
of the State of Delaware and, to the extent enforceable, the federal district courts of the United States of America will be the exclusive
forums for substantially all disputes between us and our stockholders, which could limit our stockholders’ ability to obtain a favorable
judicial forum for disputes with us or our directors, officers, or employees.
The Charter provides that,
unless we consent to the selection of an alternative forum, the Court of Chancery of the State of Delaware is the exclusive forum for
the following types of actions or proceedings under Delaware statutory or common law:
| ● | any derivative action or proceeding brought on our behalf; |
| ● | any action asserting a breach of fiduciary duty; |
| ● | any action asserting a claim against us or any of our current
or former directors, officers or other employees arising under the DGCL, the Charter,
or the Bylaws; |
| ● | any action seeking to interpret, apply, enforce or determine
the validity of this Charter or our Bylaws; |
| ● | any action as to which the DGCL confers jurisdiction on the
Court of Chancery of the State of Delaware; and |
| ● | any action asserting a claim against us that is governed
by the internal-affairs doctrine. |
This provision would not
apply to suits brought to enforce a duty or liability created by the Exchange Act. Furthermore, Section 22 of the Securities
Act creates concurrent jurisdiction for federal and state courts over all such Securities Act actions. Accordingly, both state and federal
courts have jurisdiction to entertain such claims. To prevent having to litigate claims in multiple jurisdictions and the threat of inconsistent
or contrary rulings by different courts, among other considerations, the Charter further provides that, unless we consent to the selection
of an alternative forum, the federal district courts of the United States of America will be the exclusive forum for resolving any
complaint asserting a cause of action arising under the Securities Act, including all causes of action asserted against any defendant
named in such complaint. While the Delaware courts have determined that such choice of forum provisions are facially valid and several
state trial courts have enforced such provisions and required that suits asserting Securities Act claims be filed in federal court, there
is no guarantee that courts of appeal will affirm the enforceability of such provisions and a stockholder may nevertheless seek to bring
a claim in a venue other than those designated in the exclusive forum provisions. In such instance, we would expect to vigorously assert
the validity and enforceability of the exclusive forum provisions of the Charter. This may require significant additional costs associated
with resolving such action in other jurisdictions and there can be no assurance that the provisions will be enforced by a court in those
other jurisdictions. If a court were to find either exclusive forum provision in the Charter to be inapplicable or unenforceable in an
action, we may incur further significant additional costs associated with litigating Securities Act claims in state court, or both state
and federal court, which could seriously harm our business, financial condition, results of operations, and prospects. These exclusive
forum provisions may limit a stockholder’s ability to bring a claim in a judicial forum that it finds favorable for disputes with
us or our directors, officers, or other employees, or could result in increased costs for a stockholder to bring a claim, particularly
if they do not reside in or near Delaware, both of which may discourage lawsuits against us and our directors, officers and other employees.
If a court were to find either exclusive forum provision in the Charter to be inapplicable or unenforceable in an action, we may incur
further significant additional costs associated with resolving the dispute in other jurisdictions, all of which could seriously harm our
business.
We will incur increased costs and demands
upon management as a result of complying with the laws and regulations affecting public companies, which could adversely affect our business,
results of operations, and financial condition.
As a public company, we are
subject to the reporting requirements of the Exchange Act, the listing standards of Nasdaq, and other applicable securities rules and
regulations. We expect that the requirements of these rules and regulations will continue to increase our legal, accounting and financial
compliance costs, make some activities more difficult, time-consuming and costly, and place significant strain on our personnel, systems
and resources. For example, the Exchange Act requires, among other things, that we file annual, quarterly and current reports with respect
to our business and results of operations. As a result of the complexity involved in complying with the rules and regulations applicable
to public companies, our management’s attention may be diverted from other business concerns, which could harm our business, results
of operations and financial condition. Although we have already hired additional employees to assist us in complying with these requirements,
we may need to hire more employees in the future or engage outside consultants, which will increase our operating expenses.
In addition, changing laws,
regulations and standards relating to corporate governance and public disclosure are creating uncertainty for public companies, increasing
legal and financial compliance costs, and making some activities more time-consuming. These laws, regulations and standards are subject
to varying interpretations, in many cases due to their lack of specificity, and, as a result, their application in practice may evolve
over time as new guidance is provided by regulatory and governing bodies. This could result in continuing uncertainty regarding compliance
matters and higher costs necessitated by ongoing revisions to disclosure and governance practices. We intend to invest substantial resources
to comply with evolving laws, regulations and standards, and this investment may result in increased general and administrative expenses
and a diversion of management’s time and attention from business operations to compliance activities. If our efforts to comply with
new laws, regulations and standards differ from the activities intended by regulatory or governing bodies due to ambiguities related to
their application and practice, regulatory authorities may initiate legal proceedings against us and our business may be harmed.
We also expect that being
a public company and these new rules and regulations will make it more expensive for us to obtain director and officer liability insurance,
and we may be required to accept reduced coverage or incur substantially higher costs to obtain coverage. These factors could also make
it more difficult for us to attract and retain qualified members of our board of directors, particularly to serve on our audit committee
(the “Audit Committee”) and compensation committee (the “Compensation Committee”), and qualified executive officers.
As a result of disclosure
of information in the filings required of a public company, our business and financial condition will become more visible, which may result
in an increased risk of threatened or actual litigation, including by competitors and other third parties. If such claims are successful,
our business and results of operations could be harmed, and even if the claims do not result in litigation or are resolved in our favor,
these claims, and the time and resources necessary to resolve them, could divert the resources of our management and harm our business,
results of operations, and financial condition.
As a result of becoming a public company,
we are obligated to develop and maintain proper and effective internal controls over financial reporting and any failure to maintain the
adequacy of these internal controls may adversely affect investor confidence in our company and, as a result, the value of our common
stock.
We are required, pursuant
to Section 404, to furnish a report by management on, among other things, the effectiveness of our internal controls over financial
reporting. In 2026, five years after our IPO, we will be required to comply with auditor attestation requirements, as required by Section 404.
This will require that we incur substantial additional professional fees and internal costs to expand our accounting and finance functions
and that we expend significant management efforts.
We may identify weaknesses
in our system of internal financial and accounting controls and procedures that could result in a material misstatement of our consolidated
financial statements. Our control over financial reporting will not prevent or detect all errors and all fraud. A control system, no matter
how well designed and operated, can provide only reasonable, not absolute, assurance that the control system’s objectives will be
met. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that misstatements
due to error or fraud will not occur or that all control issues and instances of fraud will be detected.
Any failure to maintain internal
control over financial reporting could severely inhibit our ability to accurately report our financial condition, results of operations
or cash flows. If our financial statements are not accurate, investors may not have a complete understanding of our operations. If we
do not file financial statements on a timely basis as required by the SEC, we could face severe consequences. If we are unable to conclude
that its internal control over financial reporting is effective, investors may lose confidence in the accuracy and completeness of our
financial reports, the market price of our Common Stock could decline, and we could be subject to sanctions or investigations by the Nasdaq,
the SEC or other regulatory authorities. Moreover, responding to such investigations, are likely to consume a significant amount of our
management resources and cause us to incur significant legal and accounting expenses. Failure to remedy any material weakness in internal
control over financial reporting, or to maintain effective control systems, could also restrict our future access to the capital markets.
This could result in an adverse reaction in the financial markets due to a loss of confidence in the reliability of our financial statements.
As a public reporting company, we are subject
to filing deadlines for reports that we file pursuant to the Exchange Act, and our failure to timely file such reports may have material
adverse consequences on our business.
Following the consummation of the Business Combination, we failed to
timely file our Form 8-K with Form 10 information prior to the “staleness” date (as determined in accordance with the applicable
rules and regulations of the SEC) applicable to the financial statements that were required by the applicable accounting requirements
and other rules and regulations of the SEC to be included in such filing (including pro forma financial information); thus, we have not
remained current in our reporting requirements with the SEC since we became an SEC reporting company on February 14, 2024. Although we
have since regained status as a current filer by filing a Form 8-K/A with current financial statements on April 1, 2024, we will not be
eligible to use a registration statement on Form S-3 that would allow us to continuously incorporate by reference our SEC reports into
the registration statement, or to use “shelf” registration statements to conduct offerings, until approximately one year from
the date we regained (and maintain) status as a current filer. Until such time, if we determine to pursue an offering, we would be required
to conduct the offering on an exempt basis, such as in accordance with Rule 144A, or file a registration statement on Form S-1. Using
a Form S-1 registration statement for a public offering would likely take significantly longer than using a registration statement on
Form S-3 and increase our transaction costs, and could, to the extent we are not able to conduct offerings using alternative methods,
adversely impact our liquidity, ability to raise capital or complete acquisitions in a timely manner. The use of Form S-1 would also prevent
us from conducting offerings on a “shelf basis,” limiting our flexibility as to the terms, timing or manner of any such offering.
We cannot guarantee that
in the future our reporting will always be timely. If we are unable to satisfy SEC filing deadlines or otherwise provide disclosures of
material information on a timely basis, stockholders and potential investors in our Common Stock may have incomplete information about
our business and results of operations, which may impact their ability to make an informed investment decision, result in a reduction
in the trading price, trading volume or analyst coverage of our Common Stock or expose us to potential liability.
We could be subject to securities class
action litigation.
In the past, securities class
action litigation has often been brought against a company following a decline in the market price of its securities. This risk is especially
relevant for us because biopharmaceutical companies have experienced significant stock price volatility in recent years. If we face
such litigation, it could result in substantial costs and a diversion of management’s attention and resources, which could harm
our business.
Any such negative outcome
could result in payments of substantial damages or fines, damage to our reputation or adverse changes to our business practices. Defending
against litigation is costly and time-consuming, and could divert management’s attention and our resources. Furthermore, during
the course of litigation, there could be negative public announcements of the results of hearings, motions or other interim proceedings
or developments, which could have a negative effect on the market price of the our Common Stock.
Our failure to meet the continued listing
requirements of Nasdaq could result in a delisting of its securities.
If we fail to satisfy the
continued listing requirements of Nasdaq, such as the corporate governance requirements or the minimum share price requirement, Nasdaq
may take steps to delist our securities. Such a delisting would likely have a negative effect on the price of the securities and would
impair your ability to sell or purchase the securities when you wish to do so. In the event of a delisting, any action taken by us to
restore compliance with listing requirements may not allow our securities to become listed again, stabilize the market price or improve
the liquidity of our securities, prevent our securities from dropping below the Nasdaq minimum share price requirement or prevent future
non-compliance with Nasdaq’s listing requirements. Additionally, if our securities are not listed on, or become delisted from Nasdaq
for any reason, and are quoted on the over-the-counter bulletin board, an inter-dealer automated quotation system for equity securities
that is not a national securities exchange, the liquidity and price of our securities may be more limited than if we were quoted or listed
on Nasdaq or another national securities exchange.
If securities or industry analysts do not
publish research, or publish inaccurate or unfavorable research, about our business, our Common Stock share price and trading volume could
decline.
The trading market for our
Common Stock will depend, in part, on the research and reports that securities or industry analysts publish about us or our business.
If few or no securities or industry analysts cover us, the trading price for our Common Stock would likely be negatively impacted. If
one or more of the analysts who cover us downgrade our Common Stock or publish inaccurate or unfavorable research about our business,
our share price would likely decline. In addition, if our operating results fail to meet the forecast of analysts, our share price would
likely decline. If one or more of these analysts cease coverage of us or fail to publish reports on us regularly, demand for our Common
Stock could decrease, which might cause our share price and trading volume to decline.
Future sales of our Common Stock, or the
perception that future sales may occur, may cause the market price of our Common Stock to decline, regardless of our operating performance.
Due to the significant number
of redemptions of Class A common stock, par value $0.0001 per share (the “Class A common stock”), of PBAX in connection with
the Business Combination, there was a significantly lower number of shares of Class A common stock that converted into shares of our Common
Stock in connection with the Business Combination. As a result, the shares of our Common Stock being registered for resale (a portion
of which may not be resold until the expiration of the applicable lock-up period) are anticipated to constitute a considerable percentage
of our public float. Additionally, a significant portion of the shares of our Common Stock being registered for resale were purchased
by selling securityholders pursuant to investments in Legacy CERo that date from February 2017
onwards at prices considerably below the current market price of our Common Stock. This discrepancy in purchase prices may have an impact
on the market perception of our Common Stock’s value and could increase the volatility of the market price of our Common Stock or
result in a significant decline in the public trading price of our Common Stock. The registration of these shares for resale creates the
possibility of a significant increase in the supply of our Common Stock in the market. The increased supply, coupled with the potential
disparity in purchase prices, may lead to heightened selling pressure, which could negatively affect the public trading price of our Common
Stock. We will not receive the proceeds from the resale of the shares of Common Stock by the selling securityholders.
In connection with the Business Combination, 8,457,653
million shares of Common Stock were issued to the stockholders of Legacy CERo and, of such shares, only 1,755,554 are subject to contractual
lock-up restrictions and/or held by affiliates whose ability to sell is dependent upon the effectiveness of a resale registration statement.
All shares of Common Stock that are not subject to such restrictions may be sold at any time. Sales of a substantial number of our shares
of Common Stock and/or Public Warrants in the public market by our existing securityholders, or the perception that those sales might
occur, could depress the market price of our shares of Common Stock and Public Warrants and could impair our ability to raise capital
through the sale of additional equity securities. We are unable to predict the effect that such sales may have on the prevailing market
price of our shares of Common Stock and Public Warrants.
Our Warrants are exercisable for Common
Stock, the exercise of which would increase the number of shares eligible for future resale in the public market and result in dilution
to our shareholders.
As of April 1, 2024, there
were (i) 8,750,000 Public Warrants with an exercise price of $11.50 per warrant; (ii) 442,500 private placement warrants (the “Private
Placement Warrants”) with an exercise price of $11.50 per warrant; (iii) warrants to purchase an aggregate of 325,536 shares of
Common Stock (“Rollover Warrants”), at an exercise price of $10.00 per warrant that were converted from Legacy CERo warrants;
(iv) warrants to purchase 612,746 shares of Common Stock (the “Common Warrants”) with an exercise price of $9.20 per warrant;
and warrants (the “Preferred Warrants” and, together with the Public Warrants, Private Placement Warrants, Rollover Warrants,
and Common Warrants, the “Warrants”) to purchase 2,500 shares of Series A convertible preferred stock, par value $0.0001
per share (the “Series A Preferred Stock”), with an exercise price of $1,000.00 per warrant, which shares of Series A Preferred
Stock are convertible into 2,500,000 shares of Common Stock, assuming conversion at $1.00. To the extent such warrants are exercised,
additional shares of our Common Stock will be issued, which will result in dilution to the holders of our Common Stock and increase the
number of shares eligible for resale in the public market. Sales of substantial numbers of such shares in the public market could adversely
affect the market price of our Common Stock, the impact of which increases as the value of our stock price increases.
Our Warrants may not be exercised at all
and we may not receive any cash proceeds from the exercise of the Warrants.
Holders of our Warrants
will be less likely to exercise their Warrants if the exercise prices of their Warrants exceed the market price of our Common Stock.
There is no guarantee that our Warrants will continue to be in the money prior to their expiration, and as such, the Warrants may expire
worthless. As such, any cash proceeds that we may receive in relation to the exercise of the Warrants overlying shares of Common Stock
will be dependent on the trading price of our Common Stock. There is no assurance that the holders of the Warrants will elect to exercise
any or all of such Warrants. As of the date of this Annual Report, (i) all of the Private Placement Warrants and Public Warrants, which
have an exercise price of $11.50 per warrant, (ii) all of the Rollover Warrants, which have an exercise price of $10.00 per warrant, and (iii) all of the Common Warrants, which have an
exercise price of $9.20 per warrant, are “out of the money,” meaning the exercise price is higher than the market price of
our Common Stock. Holders of such “out of the money” Warrants are not likely to exercise such Warrants. There can be no assurance
that such Warrants will be in the money prior to their respective expiration dates, and therefore, we may not receive any cash proceeds
from the exercise of such Warrants.
Certain of our Warrants are accounted for
as liabilities and the changes in value of such Warrants could have a material effect on, or cause volatility in, our financial results.
In connection with the Business Combination, we assumed 8,750,000 Public
Warrants, 442,500 Private Placement Warrants and 74,977 Rollover Warrants. In addition, in connection with a private placement, we issued
612,746 Common Warrants and 2,500 Preferred Warrants. We preliminarily evaluated the accounting treatment of such Warrants and concluded
that certain of such Warrants are required to be classified as liabilities measured at fair value. The fair value of such Warrants is
remeasured on a quarterly basis with changes in the estimated fair value recorded in Other (expense) income on the condensed consolidated
statement of operations and comprehensive loss. Due to the recurring fair value measurement, we expect that we will recognize non-cash
gains or losses on such Warrants each reporting period and that the amount of such gains or losses could materially impact or cause volatility
in our financial results.
Our Earnout Shares are accounted for as
liabilities and the changes in value of such shares could have a material effect on, or cause volatility in, our financial results.
We evaluated the accounting
treatment of our Earnout Shares (as defined below) subject to forfeiture if the applicable conditions to transferability thereof are not
satisfied and determined to classify such shares as liabilities measured at fair value. The fair value of such shares is remeasured on
a quarterly basis over the earn-out period with changes in the estimated fair value recorded in Other (expense) income on the condensed
consolidated statement of operations and comprehensive loss. Due to the recurring fair value measurement, we expect that we will recognize
non-cash gains or losses on our Earnout Shares each reporting period and that the amount of such gains or losses could materially impact
or cause volatility in our financial results.
Item 1B. Unresolved Staff Comments.
None.
Item 1C. Cybersecurity.
We use, store and process data for R&D and business operations. Such data includes, but is not limited to, scientific and clinical data, financial data, strategic
information, as well as information about employees, shareholders, suppliers. This makes us subject to various cybersecurity risks that
could adversely affect our business, financial condition, and results of operations through intellectual property theft, financial theft,
fraud, extortion; harm to employees, violation of privacy laws, other litigation and legal risk, and reputational risk.
We have adopted an Enterprise Risk Management
(“ERM”) policy that includes cybersecurity risk management as a key area to which the ERM policy is applied. Our ERM program
is designed to define the corporate risk tolerance and align assumed risks to that tolerance through risk identification, prioritization,
assessment, mitigation and planned responses if risk is realized. These elements are applied to cyber-security as well as other origins
of risk.
Risk Management Oversight and Governance
Under the ultimate direction
of our Chief Executive Officer and executive management team, our risk committee (the “Risk Committee”) has primary responsibility
for overseeing the management of cybersecurity risks. It is chaired by our chief financial officer (the “Chief Financial Officer”).
Other members of the committee include internal or external representatives with relevant knowledge from the R&D, information technology, and legal functions as well as senior management. Our Chief Financial Officer has 25
years of experience, several of them as the responsible individual for information technology, cyber risk management, and executive head
of risk management.
In addition to frequent electronic
communication, the committee meets periodically and as circumstances warrant to discuss and monitor prevention, detection, mitigation
and remediation of risks from cybersecurity threats. On a regular basis, the Chief Financial Officer also updates the executive management
team on developments within the cybersecurity sphere.
The board of directors has
delegated oversight of our cybersecurity program to the Audit Committee. As provided in the Audit Committee charter, the Audit Committee
is responsible for review and assessment of a) cyber-security procedures and policies, b) cyber-security related risk mitigation initiatives,
c) significant existing or emerging cyber-security risks (if any), d) reviewing the impact, execution of event-related plans, and e) disclosure
requirements for any significant cybersecurity incident.
Our Chief Financial Officer
meets on a periodic basis with the Audit Committee of the board of directors to discuss management’s ongoing cybersecurity risk
management programs. Information will be provided about the sources and nature of cyber-security risks we face, how management assesses
likelihood and severity of the impact of such risks, progress on any active projects as well any current developments in the cybersecurity
landscape. At the Audit Committee’s discretion, material findings may be escalated to the entire board of directors. The chair of
the Audit Committee is a Chief Financial Officer with existing cyber-security and risk management responsibilities at a similar public
company.
Processes for the Identification of Cybersecurity
Threats
Under the guidance of the
Risk Committee of the board of directors and the Chief Financial Officer, we have adopted a cybersecurity risk management program that
addresses four key areas:
| ● | Identification of assets at risk from cybersecurity threats |
| ● | Identification of potential sources of cybersecurity threats |
| ● | Assessment of the status of protections in place to prevent
or mitigate cybersecurity threats |
| ● | Given that landscape, how to manage cybersecurity risks |
Our risk assessment and mitigation
program is centered on three key components:
| ● | identification of risks, which involved input from different
groups across our company; |
| ● | evaluation of the likelihood of the risks manifesting, the
severity of the potential consequences and prioritization of different risk items based on, among other things, importance to the business
and cost/benefit analysis to fully address; and |
| ● | execution – establishment of a program to address. |
Our information technology
(the “Information Technology Team”) is responsible for monitoring our information systems for vulnerabilities and mitigating
any issues. It works with others within our company to understand the severity of the potential consequences of a cybersecurity incident
and to make decisions about how to prioritize mitigation and other initiatives based on, among other things, materiality to the business.
The Information Technology Team has processes designed to keep us apprised of the different threats in the cybersecurity landscape –
this includes working with consultants, discussions with peers at other companies, and reviewing government alerts and other news items.
The team also regularly monitors our network(s) to identify security risks.
We have an employee education
program that is designed to raise awareness of cybersecurity threats to reduce our vulnerability as well as to encourage consideration
of cybersecurity risks across functions.
We monitor risks through
active (e.g., vulnerability scans) and passive (e.g., end-point protection) methods and addresses system alerts on a constant basis.
As part of the assessment
of the protections we have in place to mitigate risks from cybersecurity threats, we engage third parties to conduct risk assessments
on our systems.
Before purchasing third party
technology or other solutions that involve exposure to our assets and electronic information, our Information Technology Team performs
a review on vendors (evaluating suitability, risk, and impact) before they are approved to work with us.
Item 2. Properties.
We do not own any real estate
or other physical properties. We currently maintain our executive offices in approximately 12,000 square feet of office and laboratory
space in a multi-tenant building at 201 Haskins Way in South San Francisco, California. The lease for our headquarters expires on September
30, 2026. We believe that our existing facilities are adequate for our near-term needs. We believe that suitable additional or alternative
space would be available if required in the future on commercially reasonable terms.
Item 3. Legal Proceedings.
From time to time, we may
become involved in legal proceedings arising in the ordinary course of our business. To the knowledge of our management, there is no material
litigation, arbitration or governmental proceeding currently pending against us or any members of our management team in their capacity
as such.
Item 4. Mine Safety
Disclosures.
Not applicable.
PART II
Item
5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities.
Market Information
Our Common Stock and Public
Warrants are traded on Nasdaq under the symbols “CERO” and “CEROW,” respectively (formerly “PBAX”
and “PBAXW,” respectively).
Stockholders
As of April 1, 2024, the numbers of record holders
of our Common Stock and Public Warrants were 125 and 34, respectively, not including beneficial holders whose securities are held in street
name.
Dividends
We have never declared or paid cash dividends
on our capital stock. We do not anticipate declaring or paying, in the foreseeable future, any cash dividends on our capital stock. We
intend to retain all available funds and future earnings, if any, to fund the development and expansion of our business, and we do not
anticipate paying any cash dividends in the foreseeable future. Any future determination regarding the declaration and payment of dividends,
if any, will be at the discretion of our board of directors, subject to applicable laws, and will depend on then-existing conditions,
including our financial condition, operating results, contractual restrictions, capital requirements, business prospects and other factors
our board of directors may deem relevant.
In addition, our ability to pay cash dividends
on our capital stock in the future may be limited by the terms of any future debt, issued preferred securities, or any credit facility
agreements...
Securities Authorized for Issuance under Equity
Compensation Plans
Information about our equity
compensation plans set forth in Item 12 of Part III of this Annual Report is incorporated herein by reference.
Recent Sales of Unregistered Equity Securities
In February 2024, we issued
119,050 shares of Common Stock to an investor as commitment shares in consideration for entering into an equity line of
credit with us. The issuance of these securities was made pursuant to Section 4(a)(2) of the Securities Act, and the rules promulgated
thereunder, to accredited investors.
In February 2024, we issued an aggregate of 10,039 shares of Series
A Preferred Stock, at a price of $1,000 per share, initially convertible into 1,039,000 shares of Common Stock at $10.00 per share, and
2,500 Preferred Warrants, resulting in aggregate gross proceeds to us of approximately $10.1 million. Such issuance includes 2,180 shares
of Series A Preferred Stock, initially convertible into 2,180,000 shares of Common Stock, that were issued to certain investors in exchange
for consideration consisting of approximately $2.16 million aggregate outstanding principal amount, together with accrued and unpaid interest
thereon of approximately $0.02 million, of certain convertible promissory notes issued in June 2023 by Legacy CERo and a promissory note
issued in December 2022, as amended in December 2023, by PBAX. As additional consideration to certain investors, we also issued 612,746
Common Warrants as a structuring fee. In March 2024, with the consent of the applicable investors, a portion of the shares of Series A
Preferred Stock and Common Warrants was cancelled and reissued to the purchasers of Series B convertible preferred stock, par value $0.0001
per share (“Series B Preferred Stock”) described below.
In March 2024, we issued an aggregate of 626 shares of Series B Preferred
Stock, at a price of $1,000 per share, initially convertible into 62,600 shares of Common Stock at $10.00 per share, resulting in aggregate
gross proceeds to us of approximately $0.5 million.
The issuance of these securities
was made pursuant to 4(a)(2) of the Securities Act and Rule 506(b) of Regulation D, and the rules promulgated thereunder, to accredited
investors.
Use of Proceeds from Registered Offerings
Not
applicable.
Purchases of Equity Securities by the Issuer
and Affiliated Purchasers
None.
Item
6. [RESERVED]
Item 7. Management’s Discussion and Analysis
of Financial Condition and Results of Operations of PBAX.
The following discussion
and analysis of PBAX’s financial condition and results of operations should be read in conjunction with our audited consolidated
financial statements and the notes related thereto which are included in Item 8 of this Annual Report. Certain information contained in
the discussion and analysis set forth below includes forward-looking statements. Our actual results may differ materially from those anticipated
in these forward-looking statements as a result of many factors, including those set forth under “Cautionary Note Regarding Forward-Looking
Statements,” “Risk Factors” and elsewhere in this Annual Report.
Overview
We are a blank check company
incorporated in Delaware on June 8, 2021. We were formed for the purpose of effecting a merger, capital stock exchange, asset acquisition,
stock purchase, reorganization or similar business combination with one or more target businesses, using cash from the proceeds of our
IPO and the sale of the placement units that occurred simultaneously with the completion of our IPO, our capital stock, debt or a combination
of cash, stock and debt.
We incurred significant costs
in the pursuit of a business combination. As described below, the Business Combination was consummated on February 14, 2024, after the
date of the audited consolidated financial statements included in this Annual Report.
Recent Developments
On January 3, 2024, we held
a special meeting of stockholders (the “Third Special Meeting”). At the Third Special Meeting, our stockholders approved a
proposal to amend the Investment Management Trust Agreement (the “IMTA”), dated as of October 5, 2021, as amended by the Amendment
No. 1 dated December 20, 2022 and Amendment No. 2 dated July 7, 2023, by and between us and Continental Stock Transfer and Trust Company
(“Continental”), to extend the business combination period up to three times for one month each time from January 8, 2024
to February 8, 2024, March 8, 2024 or April 8, 2024 (the “Third IMTA Amendment”). On January 3, 2024, we entered into the
Third IMTA Amendment with Continental. Our stockholders also approved an amendment (the “Third Charter Amendment”) to our
amended and restated certificate of incorporation, as amended by the First Amendment dated December 20, 2022 and the Second Amendment
dated July 7, 2023 (as amended by the Third Charter Amendment, the “PBAX Charter”) the to provide its board of directors the
ability to extend the date by which we have to consummate a business combination up to three times for one month each time, for a maximum
of three additional months. On January 3, 2024, we filed the Third Charter Amendment with the Secretary of State of the State of Delaware,
which was subsequently corrected by a Certificate of Correction (the “Certificate of Correction”) dated January 4, 2024 to
correct certain scrivener’s errors in the Third Charter Amendment.
In connection with the approval
of the Third Charter Amendment, holders of 11,625 shares of our Class A common stock, exercised redemption rights. As a result, following
satisfaction of such redemptions, we had 6,234,582 shares of Class A common stock outstanding, of which (i) 753,332 were shares of Class
A common stock issued to the public in our IPO, which shares of Class A common stock were entitled to receive a pro rata portion of the
remaining funds in our trust account (the “Trust Account”) in connection with our initial business combination, a liquidation
or certain other events, (ii) 4,596,250 were shares of Class A common stock issued upon the conversion of an equal number of shares of
our Class B common stock, par value $0.0001 per share (“Class B common stock”), acquired by Phoenix Biotech Sponsor, LLC (“Sponsor”)
prior to our IPO, which shares of Class A common stock did not have redemption rights, and (iii) 885,000 were shares of Class A common
stock included in the private placement units acquired in the private placement by the Sponsor and other investors concurrent with our
IPO, which shares of Class A common stock did not have redemption rights.
On January 4, 2024, the Sponsor
deposited $22,600 in the Trust Account in connection with the extension of the business combination deadline. On January 4, 2024, we made
a series of payments of an aggregate of $128,133 to holders of redeemed Class A common stock (an aggregate of $11.02 per redeemed share).
On
February 5, 2024, the parties entered into Amendment No. 1 to the Business Combination Agreement to, among other things, (i) remove the
minimum cash condition, (ii) modify the stock-price based milestones such that (a) the trading price condition for the First Level Earnout
Target shall be reset from $12.50 to 125% of the Conversion Price of the Series A Preferred Stock (in each case, as defined below) upon
the reset of such Conversion Price as described below and (b) the trading price condition for the Second Level Earnout Target shall be
reset from $15.00 to 150% of the Conversion Price of the Series A Preferred Stock upon reset of such Conversion Price as described below,
and (iii) increase the aggregate number of shares of Class A common stock issuable to the stockholders of CERo in connection with the
Business Combination from 4,651,704 shares to 5,000,000 shares. Such number of shares is in addition to up to 1,200,000 shares issuable
upon satisfaction of certain earn-out conditions and 382,651 shares issuable upon exercise of rollover options or warrants.
On February 8, 2024, we
held a special meeting of stockholders (the “Fourth Special Meeting”). At the Fourth Special Meeting, our stockholders
adopted and approved: (i) the Business Combination Agreement, pursuant to which Merger Sub merged with and into CERo, with CERo
surviving the merger as a wholly-owned subsidiary of PBAX and approved the Business Combination and the other transactions and
ancillary documents contemplated by and required for the Business Combination; (ii) on a non-binding advisory basis, certain changes
to the PBAX Charter, including the name change to CERo Therapeutics Holdings, Inc., share authorizations, and others; (iii) the
issuance of Class A common stock to CERo stockholders pursuant to the Business Combination Agreement; (iv) the election of five
directors; and (v) the 2024 Equity Incentive Plan and the 2024 Employee Stock Purchase Plan, contingent of the consummation of the
Business Combination.
In connection with the approval
of the Business Combination, holders of 671,285 shares of Class A common stock, exercised redemption rights. As a result, following satisfaction
of such redemptions, we had 5,563,297 shares of Class A common stock outstanding, of which (i) 82,047 were shares of Class A common stock issued
to the public in our IPO, which shares of Class A common stock were entitled to receive a pro rata portion of the remaining funds in our
Trust Account in connection with its initial business combination, a liquidation or certain other events, (ii) 4,596,250 were shares of
Class A common stock issued upon the conversion of an equal number of shares of our Class B Shares acquired by Sponsor prior to our IPO,
which shares of Class A common stock did not have redemption rights, and (iii) 885,000 were shares of Class A common stock included in
the private placement units acquired in the private placement by the Sponsor and other investors concurrent with our IPO, which shares
of Class A common stock did not have redemption rights. On February 14, 2024, we made a series of payments of an aggregate of $7,456,463.30
to holders of redeemed Class A common stock (an aggregate of $11.11 per redeemed share).
On February 13, 2024, the parties entered into Amendment No. 2 to the
Business Combination Agreement to create two additional pools of Earnout Shares of Class A common stock, one pool of which contained 875,000
shares, which were fully vested at closing of the Business Combination and which were issued as an offset to the agreement by Sponsor
to forfeit an offsetting number of shares, and one pool of which will contain 1,000,000 shares, which will be fully vested upon the achievement
of certain regulatory milestone-based earnout targets and make certain other technical changes to the timing and process for issuance
of the 1,200,000 shares of Class A common stock subject to the other earn-out conditions set forth in the Business Combination Agreement.
On February 14, 2024, the
Business Combination between Legacy CERo and PBAX was consummated pursuant to the Business Combination Agreement.
At the effective time of
the Business Combination (the “Effective Time”), (i) each outstanding share of Legacy CERo common stock, (the “Legacy
CERo common stock”), was cancelled and converted into the right to receive shares of Common Stock of PBAX; (ii) each outstanding
option to purchase Legacy CERo common stock was converted into an option to purchase shares of Common Stock; (iii) each outstanding share
of CERo preferred stock, was converted into the right to receive shares of Common Stock, and (iv) each outstanding warrant to purchase
CERo preferred stock (the “Legacy CERo warrants”) was converted into a warrant to acquire shares of Common Stock. In addition,
each outstanding Legacy CERo convertible bridge note was exchanged for shares of Series A Preferred Stock.
In addition, the holders
of Legacy CERo common stock and Legacy CERo preferred stock have the contingent right to receive additional shares of Common Stock (the
“Earnout Shares”). At the closing of the Business Combination (the “Closing”), we issued three pools of shares
subject to forfeiture if the applicable conditions to transferability thereof are not satisfied: (i) 1,200,000 shares of Common Stock,
which will be fully vested upon the achievement of certain adjusted stock price-based earnout targets or upon a qualifying transaction
(ii) 875,000 shares of Common Stock, pursuant to a Letter Agreement, dated as of February 14, 2024 (the “Sponsor Share Forfeiture
Agreement”) which were fully vested at Closing of the Business Combination and which were issued as an offset to the Sponsor Share
Forfeiture Agreement, and (iii) 1,000,000 shares of Common Stock, which will be fully vested upon to achievement of certain regulatory
milestone-based earnout targets.
As consideration for the
Business Combination, we issued to Legacy CERo stockholders an aggregate of 7,597,638 shares of Common Stock, including 2,200,000 Earnout
Shares and 382,651 shares issuable upon exercise of rollover options or warrants.
On February 14, 2024, we
sold 10,080 shares of Series A Preferred Stock, 612,746 Common Warrants and 2,500 Preferred Warrants pursuant to the Amended and Restated
Securities Purchase Agreement, dated February 14, 2024, by and among the Company, CERo and certain accredited investors (the “Initial
Investors”) for aggregate cash proceeds of approximately $9.98 million. A portion of the issued Series A Preferred Stock were issued
as condition for extinguishment of indebtedness.
On February 14, 2024, we
entered into a common stock purchase agreement (the “First ELOC”) with an investor which allows us to elect at our sole discretion
to sell and issue, up to the lesser of $25 million or a limit determined by maximum ownership percentages. As consideration for executing
this agreement, we refunded $1 million of the proceeds of the Series A financing to the investor and $150,000 to investor counsel.
On February 23, 2024, we
entered into a purchase agreement (the “Second ELOC”) with an investor which allows us to elect at our sole discretion to
sell and issue, up to the lesser of $25 million or a limit determined by maximum ownership percentages following the termination of the
First ELOC, including as a result of the sale of the maximum amount permitted under such First ELOC or the expiration of the First ELOC
at the end of its three-year term. As consideration for executing this agreement, we will issue $500,000 of Common Stock with a per share
price determined by the five-day volume weighted average daily common share price on the five days preceding the effectiveness of the
registration statement that includes the shares pursuant to the purchase agreement.
On April 1, 2024, we sold
626 shares of Series B Preferred Stock pursuant to the Securities Purchase Agreement, dated March 28, 2024, by and among us and certain
accredited investors for aggregate cash proceeds of approximately $0.5 million.
Results of Operations
As of December 31, 2023,
we had not commenced any operations. All activity through December 31, 2023 relates to our formation, the IPO, and since the IPO, the
search for a prospective initial business combination. We will not generate any operating revenues until after the completion of a business
combination, at the earliest. We generate non-operating income in the form of interest income from the proceeds derived from the IPO placed
in the Trust Account.
For the year ended December 31, 2023, we had a net loss of $2,536,233,
which primarily consists of operating expenses of $2,892,935 and Delaware franchise taxes of $40,050, partially offset by the interest
earned on marketable securities held in Trust Account of $491,571.
For the year ended December
31, 2022, we had a net loss of $667,736, which primarily consists of operating expenses of $2,841,391 and Delaware franchise taxes of
$64,050, partially offset by the interest earned on marketable securities held in Trust Account of $2,836,864.
Liquidity and Going Concern
On October 8, 2021,
we consummated the IPO of 17,500,000 units (“Units”), at a price of $10.00 per Unit, which included the partial exercise by
the underwriter of its over-allotment option in the amount of 2,000,000 Units, generating gross proceeds of $175,000,000. Simultaneously
with the closing of the IPO, we consummated the sale of 885,000 units (the “Private Placement Units”) to the Sponsor, Cantor
Fitzgerald & Co. (“Cantor”) and Cohen & Company Capital Markets, a division of J.V.B. Financial Group, LLC (“CCM”)
at a price of $10.00 per Private Placement Unit, generating gross proceeds of $8,850,000.
Following the IPO, the partial
exercise of the over-allotment option and the sale of the Private Placement Units, a total of $178,500,000 was placed in the Trust Account
($10.20 per Unit). We incurred $12,729,318 in transaction costs, including $2,635,000 of underwriting fees, $9,150,000 of deferred underwriting
fees and $944,318 of other offering costs.
As of December 31, 2023,
we had $96,873 in our operating bank accounts, $8,436,311 in money market funds held in Trust Account to be used for a business combination
or to repurchase or redeem our Public Shares in connection therewith and a working capital deficit of $5,049,122.
For the year ended December 31, 2023, there was $1,523,604 of cash
used in operating activities.
For the year ended December
31, 2022, there was $1,092,247 of cash used in operating activities.
We used substantially all
of the funds held in the Trust Account, including any amounts representing interest earned on the Trust Account (less taxes payable),
to complete our Business Combination, including the payment of transaction costs.
In order to finance transaction
costs in connection with a business combination, our Sponsor or an affiliate of our Sponsor or certain of our officers and directors may,
but are not obligated to, loan us funds as may be required. If we complete a business combination, we may repay such loaned amounts out
of the proceeds of the Trust Account released to us. In the event that a business combination does not close, we may use a portion of
the working capital held outside the Trust Account to repay such loaned amounts, but no proceeds from our Trust Account would be used
for such repayment. Up to $1,500,000 of such loans may be converted into units of the post business combination entity, at a price of
$10.00 per unit, at the option of the lender. The units would be identical to the Private Placement Units. On December 13, 2022,
we entered into a promissory note with the Sponsor. In order to fund ongoing operations, the Sponsor will loan up to $1,500,000 to us.
On December 8, 2023, the Promissory Note was amended to increase the aggregate amount from $1,500,000 to $1,600,00. As of December 31,
2023 and 2022, there was $1,555,000 and $650,000 of outstanding borrowings under the working capital loan arrangement, respectively. On
February 14, 2024, the Sponsor surrendered the Promissory Note to us in payment of its subscription price for Series A Preferred Stock
in the financing transaction described above.
Our ability to continue as
a going concern is dependent on its ability to raise additional capital to fund its R&D activities and meet its obligations on a timely
basis. Since inception, we have incurred net losses and operating cash flow deficits, resulting in an accumulated deficit of $43.3 million
as of December 31, 2023. On February 14, 2024, we acquired the assets of CERo Therapeutics, Inc., closed a private placement with
gross proceeds of $9.8 million, and assumed the R&D operations of Legacy CERo. Additional funds are necessary to maintain current
operations and to continue R&D activities. However, there can be no assurance that sufficient funding will be available to allow us
to successfully continue its R&D activities and planned regulatory filings with the FDA. If we are unable to obtain necessary funds,
significant reductions in spending and the delay or cancellation of planned activities may be necessary. These actions would have a material
adverse effect on our business, results of operations, and prospects. These conditions raise substantial doubt about our ability to continue
as a going concern within one year from the date this Annual Report is issued. The accompanying financial statements do not include any
adjustments relating to the recoverability and classification of recorded asset amounts or the amounts and classification of liabilities
that might result from the outcome of this uncertainty.
Contractual Obligations
We do not have any long-term
debt, capital lease obligations, operating lease obligations or long-term liabilities, other than an agreement to pay the Sponsor or an
affiliate of the Sponsor a monthly fee of $20,000 for office space, administrative and shared personnel support services to us. We began
incurring these fees on October 6, 2021 and incurred these fees monthly through December 31, 2022. The payment of these fees
was suspended on December 31, 2022 and reinstated on March 31, 2023. As of December 31, 2023, there was a $75,000 outstanding
balance owed to the Sponsor.
We entered into an agreement,
commencing on the date of our listing on Nasdaq, to pay the spouse of our Chief Executive Officer a monthly consulting fee of $15,000
for assisting us in identifying and evaluating potential acquisition targets. Payment of the consulting fees ended on December 31,
2022 as part of the First Charter Amendment approval.
In addition, we have an agreement
to pay the underwriter a deferred fee of $9,150,000. The deferred fee will become payable to the representative from the amounts held
in the Trust Account solely in the event that we complete a business combination, subject to the terms of the underwriting agreement.
Prior to Closing the Business Combination, we entered into a fee modification agreement with the underwriter, pursuant to which the underwriter
received shares of Common Stock in lieu of certain cash payments.
Critical Accounting Policies
The preparation of financial
statements and related disclosures in conformity with accounting principles generally accepted in the United States of America requires
management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets
and liabilities at the date of the financial statements, and income and expenses during the periods reported. Actual results could materially
differ from those estimates. We have identified the following critical accounting policies:
Accounting for Warrants
We account for Warrants as
either equity-classified or liability-classified instruments based on an assessment of the instruments’ specific terms and applicable
authoritative guidance in ASC 480 and ASC 815, Derivatives and Hedging (“ASC 815”). The assessment considers whether the instruments
are free standing financial instruments pursuant to ASC 480, meet the definition of a liability pursuant to ASC 480, and whether the instruments
meet all of the requirements for equity classification under ASC 815, including whether the instruments are indexed to our own Common
Stock and whether the instrument holders could potentially require “net cash settlement” in a circumstance outside of our
control, among other conditions for equity classification. This assessment, which requires the use of professional judgment, was conducted
at the time of warrant issuance and as of each subsequent period end date while the instruments are outstanding. Management has concluded
that the Private Warrants and Private Placement Warrants issued pursuant to the warrant agreement qualify for equity accounting treatment.
Common Stock Subject to Possible Redemption
We account for our Common
Stock subject to possible redemption in accordance with the guidance in ASC Topic 480 “Distinguishing Liabilities from Equity.”
Common stock subject to mandatory redemption is classified as a liability instrument and is measured at fair value. Conditionally redeemable
common stock (including common stock that features redemption rights that are either within the control of the holder or subject to redemption
upon the occurrence of uncertain events not solely within our control) is classified as temporary equity. At all other times, common stock
is classified as stockholders’ equity. Our Common Stock features certain redemption rights that are considered to be outside of
our control and subject to occurrence of uncertain future events. Accordingly, Common Stock subject to possible redemption is presented
as temporary equity, outside of the stockholders’ deficit section of our balance sheets. We recognize changes in redemption value
immediately as they occur and adjust the carrying value of redeemable common stock to equal the redemption value at the end of each reporting
period. Increases or decreases in the carrying amount of redeemable common stock are affected by charges against additional paid in capital
and accumulated deficit.
Net Loss per Common Share
Net loss per share is computed
by dividing net loss by the weighted average number of shares of common stock outstanding during the period. At December 31, 2023, we did not have any dilutive securities and/or other contracts that
could, potentially, be exercised or converted into shares of common stock and then share in our earnings. As a result, diluted net loss
per share is the same as basic net loss per share for the period presented.
Recent Accounting Standards
In December 2023,
the Financial Accounting Standard Board (“FASB”) FASB issued ASU 2023-09, Income Taxes (Topic 740): Improvements to Income
Tax Disclosures (“ASU 2023-09”), which requires disclosure of incremental income tax information within the rate reconciliation
and expanded disclosures of income taxes paid, among other disclosure requirements. ASU 2023-09 is effective for fiscal years beginning
after December 15, 2024. Early adoption is permitted. Management does not believe the adoption of ASU 2023-09 will have a material impact
on its consolidated financial statements and disclosures.
In June 2016, the FASB issued Accounting Standards Update (“ASU
2016-13”) Financial Instruments – Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments
(“ASU 2016-13”). This update requires financial assets measured at amortized cost basis to be presented at the net amount
expected to be collected. The measurement of expected credit losses is based on relevant information about past events, including historical
experience, current conditions, and reasonable and supportable forecasts that affect the collectability of the reported amount. Since
June 2016, the FASB issued clarifying updates to the new standard including changing the effective date for smaller reporting companies.
The guidance is effective for fiscal years beginning after December 15, 2022, and interim periods within those fiscal years, with
early adoption permitted. We adopted ASU 2016-13 on January 1, 2023. The adoption of ASU 2016-13 did not have an impact
on our financial statements.
Management does not believe
that any other recently issued, but not yet effective, accounting standards if currently adopted would have a material effect on the accompanying
financial statements.
Item 7A. Quantitative and Qualitative
Disclosures About Market Risk.
We are a smaller reporting company as defined
by Rule 12b-2 of the Securities Exchange Act of 1934 and are not required to provide the information under this item.
Item 8. Financial Statements and Supplementary
Data.
Our consolidated financial statements for the
year ended December 31, 2023, together with the reports of our independent registered public accounting firm, appear beginning on page
F-1 of this Annual Report.
Item 9. Changes in and Disagreements with Accountants on Accounting
and Financial Disclosure.
None.
Item 9A. Controls and Procedures.
(a) Evaluation of Disclosure Controls and Procedures
Disclosure controls are procedures
that are designed with the objective of ensuring that information required to be disclosed in our reports filed under the Exchange Act
is recorded, processed, summarized, and reported within the time period specified in the SEC’s rules and forms. Disclosure controls
are also designed with the objective of ensuring that such information is accumulated and communicated to our management, including the
Chief Executive Officer and Chief Financial Officer, as appropriate to allow timely decisions regarding required disclosure.
As required by Rules 13a-15
and 15d-15 under the Exchange Act, our Chief Executive Officer and Chief Financial Officer carried out an evaluation of the effectiveness
of the design and operation of our disclosure controls and procedures as of December 31, 2023. Based upon their evaluation, our Chief
Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures (as defined in Rules 13a-15(e) and
15d-15(e) under the Exchange Act) were effective.
(b) Management’s Report on Internal Control
over Financial Reporting
As required by SEC rules
and regulations implementing Section 404 of the Sarbanes-Oxley Act, our management is responsible for establishing and maintaining
adequate internal control over financial reporting. Our internal control over financial reporting is designed to provide reasonable assurance
regarding the reliability of financial reporting and the preparation of our consolidated financial statements for external reporting purposes
in accordance with the accounting principles generally accepted in the United States of America (“GAAP”). Our internal control
over financial reporting includes those policies and procedures that:
(1) pertain to the maintenance
of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of our company;
(2) provide reasonable assurance
that transactions are recorded as necessary to permit preparation of consolidated financial statements in accordance with GAAP, and that
our receipts and expenditures are being made only in accordance with authorizations of our management and directors; and
(3) provide reasonable assurance
regarding prevention or timely detection of unauthorized acquisition, use or disposition of our assets that could have a material effect
on the consolidated financial statements.
In the Form 10-Q for each
of the three quarters in 2023, we discovered an error in the cash flow statement for the presentation of restricted cash. Due to this
error a significant deficiency in internal controls was identified. To correct this, we have revised our cash flow statement for the December
31, 2023 audited financial statements. These errors had no impact on the balance sheets or statements of operations in those periods.
Because of its inherent limitations,
internal control over financial reporting may not prevent or detect errors or misstatements in our consolidated financial statements.
Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because
of changes in conditions, or that the degree or compliance with the policies or procedures may deteriorate. Management assessed the effectiveness
of our internal control over financial reporting at December 31, 2023. In making these assessments, management used the criteria
set forth by the Committee of Sponsoring Organizations of the Treadway Commission (“COSO”) in Internal Control — Integrated
Framework (2013). Based on our assessments and those criteria, management determined that, except for the significant deficiency described
above, we maintained effective internal control over financial reporting as of December 31, 2023.
This Annual Report does not
include an attestation report of our independent registered public accounting firm due to our status as an emerging growth company under
the JOBS Act.
(c) Changes in Internal Control over Financial
Reporting
There were no changes in
our internal control over financial reporting (as such term is defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act) during
the most recent fiscal quarter that have materially affected, or are reasonably likely to materially affect, our internal control over
financial reporting. The assessment of our disclosure controls and internal control over financial reporting was conducted as of December
31, 2023 with respect to PBAX and does not reflect any changes resulting from the subsequent consummation of the Business Combination.
(d) Inherent Limitations on Effectiveness of
Controls
Our
disclosure controls and procedures and internal control over financial reporting are designed to provide reasonable assurance of
achieving the desired control objectives. Our management recognizes that any controls and procedures, no matter how well designed and
operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating
the cost-benefit relationship of possible controls and procedures. Similarly, an evaluation of controls cannot provide absolute assurance
that misstatements due to error or fraud will not occur or that all control issues and instances of fraud, if any, have been detected.
Item 9B. Other Information.
(a) On April 1, 2024, we consummated a private placement of 626 shares
of Series B Preferred Stock, pursuant to the Securities Purchase Agreement, dated March 28, 2024, by and among us and certain accredited
investors (the “Additional Investors” and, together with the Initial Investors, the “PIPE Investors”), for aggregate
cash proceeds to us of approximately $0.5 million.
(b) During the three-month
period ended December 31, 2023, none of our directors or officers (as defined in Rule 16a-1(f) of the Securities Exchange Act of 1934,
as amended) adopted, terminated or modified a Rule 10b5-1 trading arrangement or any “non-Rule 10b5-1 trading agreement” (as
defined in Item 408(c) of Regulation S-K).
Item 9C. Disclosure Regarding Foreign
Jurisdictions that Prevent Inspections.
Not applicable.
PART III
Item 10. Directors, Executive Officers
and Corporate Governance.
Executive Officers and Directors
As of April 1, 2024, our
directors and executive officers were as follows:
Name |
|
Age |
|
Title |
Executive Officers: |
|
|
|
|
Brian G. Atwood |
|
71 |
|
Chief Executive Officer, Chairman and Director |
Charles R. Carter |
|
57 |
|
Chief Financial Officer, Treasurer and Secretary |
Daniel Corey, M.D. |
|
45 |
|
Chief Technology Officer, Director and Founder |
Directors: |
|
|
|
|
Chris Ehrlich |
|
55 |
|
Vice Chairman |
Michael Byrnes |
|
47 |
|
Director |
Kathleen LaPorte |
|
62 |
|
Director |
Robyn Rapaport |
|
31 |
|
Director |
Lindsey Rolfe, M.D. |
|
56 |
|
Director |
Executive Officers
Brian G. Atwood has
served as Chairman and Chief Executive Officer since February 2024, and previously served as Chairman of PBAX from October 2021 the Closing
of the Business Combination in February 2024. Mr. Atwood serves as a Managing Director for Versant Ventures, a healthcare-focused
venture capital firm that he co-founded in 1999. In 2015, Mr. Atwood co-founded Cell Design Labs, Inc., a biotechnology
company focused on developing human cell engineering technology for the treatment of multiple diseases, including cancer, where he served
as President and Chief Executive Officer until 2017, when it was acquired by Gilead Sciences. Mr. Atwood serves on the board
of directors of Clovis Oncology, Inc. (Nasdaq: CLVS), and Atreca, Inc. (Nasdaq: BCEL), where he is Chairman. He also served on the
board of directors of Immune Design Corp. from May 2008 until June 2016 (acquired by Merck in 2019), Veracyte, Inc., from its founding
in 2008 until December 2016, OpGen Inc., from July 2007 until December 2017, Five Prime Therapeutics, from 2002 until March 2016,
Cadence Pharmaceuticals, Inc. from March 2006 until its acquisition in March 2014, Helicos Biosciences from 2003 until September
2011, Pharmion Corporation from 2000 until its acquisition in March 2008, Trius Therapeutics, Inc. from February 2007 until its acquisition
in September 2013 and Locust Walk Acquisition Corp. (Nasdaq: LWAC) from January 2021 until the consummation of its business combination
in August 2021. Mr. Atwood holds a B.S. in Biological Sciences from the University of California, Irvine, a M.S. in Ecology from
the University of California, Davis, and a M.B.A. from Harvard Business School.
Mr. Atwood was selected
to serve on our board of directors because of his experience in the biotechnology industry, his years of business and leadership experience
and his financial sophistication and expertise.
Charles Carter has
served as Chief Financial Officer and Secretary since February 2024. Prior to the business combination, Mr. Carter served as a consulting
finance executive for Legacy CERo through Danforth Advisors, LLC (“Danforth”) since February 2023, and a consultant for Danforth
since May 2022. Prior to rejoining Danforth, Mr. Carter was Chief Financial Officer and Secretary of iCAD, Inc. (Nasdaq: ICAD) from May
2021 to May 2022. Previously, Mr. Carter was Chief Financial Officer of GI Dynamics, Inc. (“GI Dynamics”), a medical device
company (ASX: GID, delisted July 2020) from December 2018 to April 2021. Prior to joining GI Dynamics in 2019, Mr. Carter was a finance
consultant with Danforth from March 2018 to September 2019. Mr. Carter has also been the Chief Financial Officer of The Guild for Human
Services, a not-for-profit community-based residential school and program for special needs students and adults, the Chief Financial Officer
for Aeris Therapeutics, Inc. and Intelligent Medical Devices, Inc. and held senior finance leadership positions at Adnexus Therapeutics,
Inc. and Transkaryotic Therapies, Inc./Shire, PLC. (Nasdaq: TKT; Nasdaq: SHPG) (“TKT”). Prior to TKT, Mr. Carter was a partner
with Mercer Management Consulting, Inc. Mr. Carter holds an M.B.A. and an M.S. in Molecular Genetics from the University of Chicago and
a B.A. in Biology from Colgate University.
Daniel Corey, M.D., has
served as our Chief Technology Officer since February 2024, and previously served as Chief Executive Officer, Chief Scientific Officer,
a member of the board of directors of Legacy CERo from its inception in 2018 until the Closing of the Business Combination of February
2024. Prior to founding Legacy CERo, from June 2012 to June 2018, Dr. Corey was a senior follow in the Division of Hematology at
Stanford University, and from June 2010 to June 2012, Dr. Corey was a fellow at Stanford University’s Institute of Stem Cell
Biology and Regenerative Medicine, where he was awarded a career development award from the National Heart Lung and Blood Center (“NHLBI”)
for work studying hematopoiesis. Dr. Corey is a member of various medical-related societies, has eight U.S. patent applications
outstanding and has written extensively in various medical publications. Dr. Corey has received various honors during his education
and career, which, among others, include the Johnson and Johnson Innovation Award; the Siebel Stem Cell Scholar, Stanford University;
the Stanford University Molecular Immunology Training Award; the NHLBI K12 Career Development Award, Stanford University; the NHLBI National
Service Research Award, Duke University. Dr. Corey received a B.A. with honors from Brown University, received his M.D. from University
of Washington School of Medicine and served as a fellow and a resident at Duke University.
Dr. Corey was selected
to serve on our board of directors based on his substantial medical and scientific experience, and, in particular, his history with Legacy
CERo and the creation of CER-T cells.
Directors
Chris Ehrlich has
served as Vice Chairman of our board of directors since February 2024, and previously served as the Chief Executive Officer of PBAX from
October 2021 until the Closing of the Business Combination in February 2024. From January 2021 to August 2021, he served as the Chief
Executive Officer of Locust Walk Acquisition Corp (Nasdaq: LWAC) until it merged with eFFECTOR Therapeutics, Inc., where he currently
serves on the board of directors. He is also the Principal of Ehrlich Bioventures, LLC, a consultancy working with emerging biopharma
companies. He previously served as Senior Managing Director and the Global Head of Strategic Transactions at Locust Walk Partners from
2013 to 2021. He brings significant biotechnology industry, business development, venture capital experience, investment banking and SPAC
experience. While at Locust Walk Partners, Mr. Ehrlich was involved with sourcing and leading multiple transactions for emerging
biopharmaceutical companies, including the sale of Xyphos Biosciences, Inc. to Astellas in 2019 and the sale of Thar Pharmaceuticals to
Grunenthal in 2018. Prior to Locust Walk Partners, he was a Managing Director at InterWest Partners (“InterWest”), a
venture capital firm. At InterWest, he served on the boards of KAI Pharmaceuticals, a privately held pharmaceutical company (acquired
by Amgen in 2012), Biomimetic Therapeutics, Inc., a biotechnology company (acquired by Wright Medical Technologies in 2013), Invuity,
Inc., a medical technology company acquired by Stryker in 2018) and Xenon Pharmaceuticals, a biopharmaceutical company (Nasdaq: XENE).
Prior to joining InterWest, Mr. Ehrlich worked as the Director of Licensing and Business Development at Purdue Pharma, in business
development at Genentech, in venture capital at the U.S. Russia Investment Fund, and in biotechnology strategy development at L.E.K. Consulting.
Mr. Ehrlich also currently serves on the board of directors of Prostate Management Diagnostics, Inc., on the advisory board of the
Peter Michael Foundation, where he is a Senior Advisor, and on the healthcare at Kellogg advisory board at Northwestern University. Mr. Ehrlich
has a B.A. in Government from Dartmouth College and an M.B.A. from the Kellogg Graduate School of Management at Northwestern University,
where he is a frequent lecturer.
Mr. Ehrlich was selected
to serve on our board of directors based on his substantial investment and acquisition experience in the biotechnology and biopharmaceutical
industries and his experience serving as a director for various public and private companies.
Michael Byrnes has
served as a member of our board of directors since February 2024. Mr. Byrnes has served as the Chief Financial Officer of eFFECTOR Therapeutics
since December 2020. Previously, Mr. Byrnes was Senior Vice President of Finance at Principia Biopharma, Inc. from January 2020 until
its acquisition by Sanofi in September 2020. Prior to that, Mr. Byrnes served as the Chief Financial Officer of Alkahest, Inc. from May
2018 to January 2020 and Chief Financial Officer of Ocera Therapeutics, Inc., from December 2014 until its acquisition by Mallinckrodt
Pharmaceuticals in December 2017. Mr. Byrnes served as Corporate Controller of Maxygen, Inc. from March 2010 to December 2014 and prior
to that, held finance positions of increasing responsibility from 2000 to 2010 with NeurogesX, Inc., Lipid Sciences, Inc. and ADAC Laboratories,
Inc., a Philips Medical Systems company. Mr. Byrnes received his B.S.C. in Finance from Santa Clara University and an M.B.A. from California
State University, Hayward.
Mr. Byrnes was selected to
serve on our board of directors based on his substantial leadership and management experience in the biopharmaceutical industry.
Kathleen LaPorte
has served as a member of our board of directors since February 2024, and previously served a member of PBAX’s board of
directors from October 2021 until the Closing of the Business Combination in February 2024. Ms. LaPorte is an experienced executive,
founder and board member, focused on life sciences. She co-founded New Leaf Ventures, served as a General Partner of The Sprout
Group, and was Chief Business Officer and Chief Executive Officer of Nodality Inc. Ms. LaPorte has served on sixteen public company
boards and fourteen public company audit committees and numerous private company boards. Ms. Laporte currently serves as an
independent director for Bolt Biotherapeutics (Nasdaq: BOLT), Precipio Diagnostics (Nasdaq: PRPO), 89Bio (Nasdaq: ENTB), Elysium
Therapeutics, and Q32 Bio Inc. (Nasdaq: QTTB). Ms. LaPorte serves as the chair of the audit committees of Bolt Biotherapeutics,
Precipio Diagnostics and Q32 Bio Inc. and as the chair of the compensation committee of 89Bio. She previously served on the
California Institute for Regenerative Medicine, a state agency board. Ms. LaPorte has a B.S. degree in Biology from Yale University
and a M.B.A. from the Stanford University Graduate School of Business.
Ms. LaPorte was selected
to serve on our board of directors based on her extensive leadership and management experience in the life sciences industry.
Robyn Rapaport has
served as a member of our board of directors since February 2024. Ms. Rapaport has served a principal overseeing alternative investments
at Rapaport Capital since November 2021. Prior to that, Ms. Rapaport was an entrepreneur at the University of California, Los Angeles
Anderson Venture Accelerator, from June 2019 to December 2020. Ms. Rapaport holds an M.B.A. from the University of California, Los Angeles
and a B.A. from the University of Pennsylvania in history and consumer psychology.
Ms. Rapaport was selected
to serve our board of directors based on her financial and operational experience.
Lindsey Rolfe, M.D.,
has served as a member of our board of directors since February 2024. Dr Rolfe has served as Chief Medical Officer at 3B Pharmaceuticals
GmbH since August 2023 and previously served as Chief Medical Officer at Clovis Oncology Inc. from August 2015 to June 2023, and served
as Senior Vice President of Clinical Development from 2010. At Clovis, Dr. Rolfe oversaw the development team that obtained approvals
for Rubraca as an ovarian cancer treatment in the United States and Europe, and was responsible for all pre- and post-marketing medical
activities. Dr. Rolfe has more than 20 years of drug development experience and previously served in senior oncology development
roles at Celgene Corporation, Pharmion Corporation, Cambridge Antibody Technology, UCB Inc. and Celltech Group plc. In addition, Ms. Rolfe
has served as an independent director at Atreca Inc. (Nasdaq: BCEL) since August 2019. Dr. Rolfe holds a BSc Anatomy and Bachelor
of Medicine and Surgery from the University of Edinburgh, undertook post-graduate medical training in London, UK and obtained her post-graduate
internal medicine qualification as a Member of the Royal College of Physicians. She has specialist accreditation in Pharmaceutical Medicine
from the UK General Medical Council and is a Fellow of the Faculty of Pharmaceutical Medicine in the UK.
Dr. Rolfe was selected
to serve on our board of directors based on her experience in leading drug discovery and development of therapeutics.
Family Relationships
There are no family relationships
between our board of directors and any of our executive officers.
Board of Directors
Director Independence
Nasdaq listing rules require
that a majority of the board of directors of a company listed on Nasdaq be composed of “independent directors,” which is defined
generally as a person other than an officer or employee of a company or its subsidiaries or any other individual having a relationship,
which, in the opinion of such company’s board of directors, would interfere with the director’s exercise of independent judgment
in carrying out the responsibilities of a director. Based on business and personal information provided
by each director concerning her or his background, employment, and affiliations, including family relationships, our board of directors
has determined that each of Mr. Byrnes, Mr. Ehrlich, Ms. LaPorte, Ms. Rapaport and Dr. Rolfe is an independent director under the Nasdaq
listing rules and Rule 10A-3 of the Exchange Act. In addition, we determined that each of Brian G. Atwood, Barbara A. Kosacz and
Caroline M. Loewy, who served on the board of directors during fiscal year 2023, was also an independent director under the Nasdaq
listing rules and Rule 10A-3 of the Exchange Act; provided, however, that in connection with Mr. Atwood’s appointment as our Chief
Executive Officer at the Closing, Mr. Atwood is no longer independent.
In
addition, the rules of Nasdaq require that, subject to specified exceptions, each member of a listed company’s audit, compensation
and nominating and corporate governance committees be independent. Under the rules of Nasdaq, a director will only qualify as an “independent
director” if, in the opinion of that company’s board of directors, that person does not have a relationship that would interfere
with the exercise of independent judgment in carrying out the responsibilities of a director. In making these determinations,
our board of directors considered the current and prior relationships that each non-employee director has with us and all other facts
and circumstances our board of directors deemed relevant in determining independence, including the beneficial ownership of our Common
Stock by each non-employee director and relationships with each of PBAX and Legacy CERo.
Classified Board of Directors
In accordance with the terms
of our Charter, our board of directors is divided into three classes with staggered, three-year terms. At each annual meeting of stockholders,
the directors whose terms then expire will be eligible for reelection until the third annual meeting following reelection. Our directors
are divided among the three classes as follows:
| ● | the Class I directors are Mr. Byrnes and Ms. Rolfe, and their
terms will expire at our 2025 annual meeting of stockholders; |
| ● | the Class II directors are Ms. Rapaport, Mr. Atwood and Ms.
LaPorte, and their terms will expire at our 2026 annual meeting of stockholders; and |
| ● | the Class III directors are Mr. Corey and Mr. Ehrlich, and
their terms will expire at our 2027 annual meeting of stockholders. |
Our Bylaws provide that the
number of members of our board of directors shall be fixed in accordance with our Charter. Our Charter provides that the authorized number
of directors may be changed only by resolution of the board of directors. Any additional directorships resulting from an increase in the
number of directors will be distributed among the three classes so that, as nearly as possible, each class will consist of one-third of
the directors. Our board of directors is currently fixed at seven members. The division of our board of directors into three classes with
staggered three-year terms may delay or prevent a change of our board of directors or a change in control of our company. Our directors
may be removed only for cause by the affirmative vote of the holders of at least two-thirds of our outstanding voting stock then entitled
to vote in an election of directors.
Director Attendance at Annual Meeting of
Stockholders
We encourage our directors
to attend our annual meetings of stockholders. We did not hold an annual meeting of stockholders during the fiscal year ended December
31, 2023.
Board and Committee Meetings
During the fiscal year
ended December 31, 2023, our board of directors met four times, our Audit Committee met four times, our Compensation Committee
and our nominating and corporate governance committee met zero times.
Each board member attended 75% or more of the aggregate number of meetings of the board of directors and meetings of the committees
on which he or she served during the fiscal year ended December 31, 2023, for which he or she was a director or committee
member.
Board Leadership Structure
Our board of directors does
not have a policy regarding separation of the roles of Chief Executive Officer and chairman of the board of directors. Our board of directors
recognizes that it is important to determine an optimal board leadership structure to ensure the independent oversight of management as
we continue to grow, and believes it is in our best interests to make determinations regarding such leadership structure based on circumstances
from time to time. Currently, our Chief Executive Officer serves as the chairman of the board of directors.
Our board of directors believe
that this leadership structure, combined with our corporate governance policies and processes, creates an appropriate balance between
strong and consistent leadership and independent oversight of our business. The chairman chairs the meetings of our board of directors
and stockholders, with input from the independent directors, and as such, our board of directors believes that a person with comprehensive
knowledge of our company is in the best position to serve such role. In making this determination, the board of directors considered,
among other matters, Mr. Atwood’s management of our business on a day-to-day basis coupled with his direct involvement in our business
operations, and believed that Mr. Atwood is highly qualified to act as both chairman and Chief Executive Officer due to his experience,
knowledge and history with both Legacy CERo and PBAX.
In addition, each of our
other directors is “independent” under Nasdaq standards. Our independent vice chairman presides over regularly-held executive
sessions of independent directors, without management present, and all of our independent directors are active in the oversight of our
company. In addition, our board of directors and each committee of board of directors has complete and open access to any member of management
and the authority to retain independent legal, financial and other advisors as they deem appropriate.
Our board of directors believe
its administration of its risk oversight function has not affected its leadership structure. Risk is inherent with every business, and
how well a business manages risk can ultimately determine its success. Our board of directors is actively involved in oversight of risks
that could affect us. This oversight is conducted primarily by our full board of directors, which has responsibility for general oversight
of risks, and the Audit Committee, which has responsibility for reviewing the adequacy of our risk management activities with management
and our independent registered public accounting firm.
At each of its meetings,
the board of directors receives business updates from various members of management. These updates may identify matters that have emerged
within that member of management’s scope of responsibility that involve operational, financial, legal or regulatory risks and, in
these cases, the board of directors provides guidance to management. Our board of directors believes that full and open communication
between management and the board of directors is essential for effective risk management and oversight.
Our board of directors has
concluded that our current leadership structure is appropriate at this time. However, our board of directors will continue to periodically
review our leadership structure and may make such changes in the future as it deems appropriate.
Role of Board in Risk Oversight
Our board of directors has
responsibility for the oversight of our risk management processes and, either as a whole or through its committees, regularly discusses
with management our major risk exposures, their potential impact on our business and the steps we take to manage them. The risk oversight
process includes receiving regular reports from board committees and members of senior management to enable our board of directors to
understand our risk identification, risk management and risk mitigation strategies with respect to areas of potential material risk, including
operations, finance, legal, regulatory, strategic and reputational risk.
The Audit Committee reviews
information regarding liquidity and operations, and oversees our management of financial risks. It also reviews information and policies
related to information technology risk, including cyber-security and incident response planning. Periodically, the Audit Committee reviews
our policies with respect to risk assessment, risk management, loss prevention and regulatory compliance. Oversight by the Audit Committee
includes direct communication with our external auditors, and discussions with management regarding significant risk exposures and the
actions management has taken to limit, monitor or control such exposures. The Compensation Committee is responsible for assessing whether
any of our compensation policies or programs has the potential to encourage excessive risk-taking. The nominating and corporate governance
committee manages risks associated with the independence of the board of directors, corporate disclosure practices and potential conflicts
of interest. While each committee is responsible for evaluating certain risks and overseeing the management of such risks, the entire
board of directors is regularly informed through committee reports about such risks. Matters of significant strategic risk are considered
by our board of directors as a whole.
Committees of the Board of Directors
The standing committees of
our board of directors include the Audit Committee, a Compensation Committee, and a nominating and corporate governance committee, each
of which operates under a charter that has been approved by our board of directors. Such charters are available on our website at www.cero.bio/investors.
The reference to our website address does not constitute incorporation by reference of the information contained at or available through
our website. We have included our website address as an inactive textual reference only.
Audit Committee
The members of our Audit
Committee are Mr. Byrnes, Mr. Ehrlich, and Ms. Rapaport. Mr. Byrnes serves as the chairperson of the Audit Committee. All members of our
Audit Committee meet the requirements for financial literacy under the applicable rules and regulations of the SEC and Nasdaq. Our board
of directors has determined that Mr. Byrnes is an “audit committee financial expert” as defined by applicable SEC rules and
has the requisite financial sophistication as defined under the applicable Nasdaq listing standards. Our board of directors has determined
each of Mr. Byrnes, Mr. Ehrlich and Ms. Rapaport is independent under the applicable rules of the SEC and Nasdaq and has
the requisite financial expertise required under the applicable requirements of Nasdaq. In
arriving at this determination, our board of directors has examined each Audit Committee
member’s scope of experience and the nature of their experience reading and understanding financial statements.
The Audit Committee’s
main function is to oversee our accounting and financial reporting processes and the audits of our consolidated financial statements.
The Audit Committee’s responsibilities include, among other things:
| ● | selecting a qualified firm to serve as the independent registered public accounting firm to audit our financial statements; |
| ● | helping to ensure the independence and performance of the independent registered public accounting firm; |
| ● | discussing the scope and results of the audit with the independent registered public accounting firm, and reviewing, with management
and the independent accountants, our annual audited financial statements and quarterly financial statements; |
| ● | developing procedures for employees to submit concerns anonymously about questionable accounting or audit matters; |
| ● | reviewing and discussing policies on risk assessment and risk management; |
| ● | discussing or considering the our major risk exposures such as financial, operational, privacy, security, cybersecurity, competition,
legal, regulatory, hedging and accounting and the steps that our management has taken to monitor and control such exposures; |
| ● | reviewing related party transactions; |
| ● | obtaining and reviewing a report by the independent registered public accounting firm at least annually that describes the internal
quality-control procedures, any material issues with such procedures, and any steps taken to deal with such issues when required by applicable
law; and |
| ● | approving (or, as permitted, pre-approving) all audit and all permissible non-audit service to be performed by the independent registered
public accounting firm. |
Compensation Committee
The members of our Compensation
Committee are Mr. Ehrlich, Ms. LaPorte and Dr. Rolfe. Ms. LaPorte serves as the chairperson of the Compensation Committee. Our board of
directors has determined that each of Mr. Ehrlich, Ms. LaPorte and Dr. Rolfe is independent under the applicable Nasdaq listing standards
and is a “non-employee director” as defined in Rule 16b-3 promulgated under the Exchange Act.
Our Compensation Committee’s
main function is to oversee our compensation structure, policies and programs and to review
the processes and procedures for the consideration and determination of director and executive compensation.
The Compensation Committee’s responsibilities include, among other things:
| ● | recommending to the board of directors goals and objectives, non-equity compensation, and equity grants of all senior officers; |
| ● | recommending to the board of directors goals and objectives, non-equity compensation, and equity grants for the Chief Executive Officer; |
| ● | recommending to the board of directors non-equity compensation and equity grants for the directors; |
| ● | reviewing and discussing with the board of directors corporate succession plans for the Chief Executive Officer and key officers; |
| ● | reviewing and discussing with management its talent development and related initiatives; |
| ● | assisting the board of directors with its oversight of our strategies, programs, and initiatives related to employee health, safety,
and well-being, engagement, pay equity, and diversity and inclusion; |
| ● | selecting independent compensation consultants and assessing whether there are any conflicts of interest with any of the Compensation
Committee’s compensation advisors; |
| ● | reviewing and recommending to the board of directors employment agreements, severance arrangements and change-of-control agreements
or provisions for executive officers and other senior management, as appropriate; and |
| ● | reviewing the policies relating to compensation and benefits of employees. |
Nominating and Corporate Governance Committee
The members of our nominating
and corporate governance committee are Dr. Rolfe, Ms. LaPorte and Ms. Rapaport. Dr. Rolfe serves as the chairperson of the committee.
Our board of directors has determined that each of Dr. Rolfe, Ms. LaPorte and Ms. Rapaport is independent under the applicable Nasdaq
listing standards.
The nominating and corporate
governance committee’s main function is to consider candidates for board membership and oversee our corporate governance policies,
reporting and making recommendations to our board of directors concerning governance matters and oversight of the evaluation of our board
of directors. The nominating and corporate governance committee’s responsibilities include, among other things:
| ● | recommending to the board of directors for its approval criteria for board of directors and committee membership; |
| ● | establishing a process for identifying and evaluating board of director candidates, including nominees recommended by stockholders; |
| ● | identifying individuals qualified to become members of the board of directors; |
| ● | recommending to the board of directors the persons to be nominated for election as directors and to each of the committees of the
board of directors; |
| ● | developing and recommending to the board of directors corporate governance guidelines and periodically reviewing those guidelines
and the code of conduct and business ethics and recommending any changes; and |
| ● | overseeing a periodic evaluation of the board of directors and its committees. |
Director Nomination Process
Our board of directors is
responsible for filling vacancies on our board of directors and for nominating candidates for election by our stockholders each year in
the class of directors whose term expires at the relevant annual meeting. The board of directors delegates the selection and nomination
process to the nominating and corporate governance committee, with the expectation that other members of the board of directors, and of
management, will be requested to take part in the process as appropriate.
The nominating and corporate
governance committee considers candidates for board of director membership suggested by its members and our Chief Executive Officer. Additionally,
in selecting nominees for directors, the nominating and corporate governance committee will review candidates recommended by stockholders
in the same manner and using the same general criteria as candidates recruited by the committee and/or recommended by our board of directors.
The nominating and corporate governance committee may gather information about the candidates through interviews, detailed questionnaires,
comprehensive background checks or any other means that the nominating and corporate governance committee deems to be appropriate in the
evaluation process.
Our nominating and corporate
governance committee and our board of directors consider a broad range of factors relating to the qualifications of nominees. Our nominating
and corporate governance committee’s and our board of directors’ priority in selecting board members is the identification
of persons who will provide a composite mix of backgrounds, experience, knowledge and capabilities that will allow our board of directors
to promote our strategic objectives and fulfill its responsibilities to our stockholders. Our nominating and corporate governance committee
and our board of directors highly value diversity and, as such, also consider diversity of gender, race, ethnicity, age, gender identity,
gender expression and sexual orientation when selecting members of our board of directors.
Any stockholder who wishes
to recommend a candidate for consideration by the committee as a nominee for director should follow the procedures described in our proxy
statement to be filed with the SEC in connection with our 2024 special meeting of stockholders within 120 days after the end of the fiscal
year ended December 31, 2023. The nominating and corporate governance committee will also consider whether to nominate any person proposed
by a stockholder in accordance with the provisions of our Bylaws relating to stockholder nominations.
Compensation Committee Interlocks and Insider
Participation
During the fiscal year ended
December 31, 2023, Mr. Ehrlich served as the Chief Executive Officer of our predecessor, PBAX. In connection with the Business Combination,
on February 14, 2024, Mr. Ehrlich ceased to be an officer of PBAX. Other than Mr. Ehrlich, during the fiscal year ended December 31, 2023
and as of the date of this Annual Report, none of the members of our Compensation Committee has ever been one of our officers or employees.
None of our executive officers currently serves, or has served, as a member of our board of directors or Compensation Committee of any
entity that has one or more executive officers serving as a member of our board of directors or Compensation Committee.
Board Diversity
Board diversity and inclusion
is critical to our success. While we do not have a formal policy on board of directors diversity, the board of directors is committed
to building a board of directors that consists of the optimal mix of skills, expertise, and diversity capable of effectively overseeing
the execution of our business and meeting our evolving needs, with diversity reflecting gender, age, race, ethnicity, background, professional
experience and perspectives. Our nominating and corporate governance committee considers the value of diversity on the board of directors
in evaluating director nominees. Accordingly, the nominating and corporate governance committee’s evaluation of director nominees
includes consideration of their ability to contribute to the diversity of personal and professional experiences, opinions, perspectives
and backgrounds on the board of directors.
The matrix below provides
certain highlights of the composition of our board of directors based on self-identification. Each term used above and in the matrix below
has the meaning given to it in Nasdaq Listing Rule 5605(f).
Board Diversity Matrix (As of March 20, 2024) |
Total Number of Directors: | |
7 | |
| |
Female | | |
Male | | |
Non- Binary | | |
Did Not Disclose Gender | |
Part I: Gender Identity | |
| | |
| | |
| | |
| |
Directors | |
| 3 | | |
| 4 | | |
| | | |
| | |
Part II: Demographic Background | |
| | | |
| | | |
| | | |
| | |
African American or Black | |
| | | |
| | | |
| | | |
| | |
Alaskan Native or Native American | |
| | | |
| | | |
| | | |
| | |
Asian | |
| | | |
| | | |
| | | |
| | |
Hispanic or Latinx | |
| | | |
| | | |
| | | |
| | |
Native Hawaiian or Pacific Islander | |
| | | |
| | | |
| | | |
| | |
White | |
| 3 | | |
| 4 | | |
| | | |
| | |
Two or More Races or Ethnicities | |
| | | |
| | | |
| | | |
| | |
LGBTQ+ | |
| | | |
| | | |
| | | |
| | |
| |
| | | |
| | | |
| | | |
| | |
Did Not Disclose Demographic Background | |
| | | |
| | | |
| | | |
| | |
Communication with Directors
Any stockholder or interested
party may communicate with our board of directors, as a whole, or with individual directors on the board of directors, through an established
process for stockholder and other interested party communication. For a communication directed to the board of directors as a whole, stockholders
and other interested parties may submit a written communication by postal mail to the attention of the chairman of our board of directors
at the following address: CERo Therapeutics Holdings, Inc., 210 Haskins Way, Suite 230, South San Francisco, CA 94080.
For a communication directed
to an individual director in his capacity as a member of the board of directors, stockholders and other interested parties may send such
communication to the attention of the individual director at the following address: CERo Therapeutics Holdings, Inc., c/o Corporate
Secretary, 210 Haskins Way, Suite 230, South San Francisco, CA 94080, Attention: Name of Individual Director.
We will forward by U.S. mail
any such communication to each director, and the chairman of the board of directors in his capacity as a representative of the board of
directors, to whom such communication is addressed to the address specified by each such director and the chair of the board of directors,
unless there are safety or security concerns that mitigate against further transmission. A copy of any such written communication may
also be forwarded to our general counsel and a copy of such communication may be retained for a reasonable period of time. You may submit
your concern anonymously or confidentially.
Communications may be forwarded
to other directors if they relate to important substantive matters and include suggestions or comments that may be important for other
directors to know. In general, communications relating to corporate governance and long-term corporate strategy are more likely to be
forwarded than communications relating to ordinary business affairs, personal grievances and matters as to which we tend to receive repetitive
or duplicative communications.
Code of Business Conduct and Ethics
We have adopted a written
code of business conduct and ethics that applies to our directors, officers, and employees, including our principal executive officer,
principal financial officer, principal accounting officer or controller, or persons performing similar functions. Our code of business
conduct and ethics is available under the Investors section of our website at www.cero.bio/investors. In addition, we intend to
post on our website all disclosures that are required by law or the listing standards of Nasdaq concerning any amendments to, or waivers
from, any provision of the code of business conduct and ethics. The reference to our website address does not constitute incorporation
by reference of the information contained at or available through our website. We have included our website address as an inactive textual
reference only.
Insider Trading Arrangements and Policies
During the three months ended
December 31, 2023, none of our directors or officers adopted, amended, or terminated a “Rule 10b5-1 trading arrangement” or
“non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.
Our board of directors has
adopted an insider trading policy which governs the purchase, sales, and/or other dispositions of our securities by directors, officers,
and employees. Our insider trading policy is attached hereto as Exhibit 19 and incorporated herein. In addition, we have adopted a Rule
10b5-1 trading plan policy, which permits our officers, directors, and certain other persons to enter into trading plans complying with
Rule 10b5-1 under the Exchange Act. Generally, under these trading plans, the individual relinquishes control over the transactions once
the trading plan is put into place and can only put such plans into place while the individual is not in possession of material non-public
information. Accordingly, sales under these plans may occur at any time, including possibly before, simultaneously with, or immediately
after significant events involving us.
Policy on Trading, Pledging and Hedging of
Company Stock
Certain transactions in our
securities (such as purchases and sales of publicly traded put and call options, and short sales) create a heightened compliance risk
or could create the appearance of misalignment between management and stockholders. In addition, securities held in a margin account or
pledged as collateral may be sold without consent if the owner fails to meet a margin call or defaults on the loan, thus creating the
risk that a sale may occur at a time when an officer or director is aware of material, non-public information or otherwise is not permitted
to trade in our securities. Our insider trading policy expressly prohibits derivative transactions of our stock by our executive officers,
directors and employees. In addition, our insider trading policy also expressly prohibits purchases of any derivative securities that
provide the economic equivalent of ownership.
Item 11. Executive Compensation.
Except as otherwise specified in this Item 11, the information set
forth herein relates to the executive compensation paid by Legacy CERo prior to the Business Combination, and agreements with the Company,
effective as of the Business Combination. PBAX did not pay any compensation to any of its directors or executive officers at any time
from it Initial Public Offering through the completion of the Business Combination. This section discusses the material components of
the executive compensation program for our named executive officers. Our only named executive officer for the fiscal year ended December 31,
2023 was Dr. Corey, as Dr. Corey was the only executive officer during the period presented.
2023 Summary Compensation Table
None of PBAX’s executive officers received any compensation for
services rendered in 2023. The following table presents
all of the compensation awarded to the sole named executive officer of Legacy CERo during the years listed below.
Name and Principal Position | |
Year | | |
Salary ($) | | |
All Other Compensation ($)(1) | | |
Total ($) | |
Dr. Daniel Corey | |
| 2023 | | |
| 360,000 | | |
| 16,035 | | |
| 376,035 | |
Chief Technology Officer and Former Chief Executive Officer | |
| 2022 | | |
| 360,000 | | |
| 12,685 | | |
| 372,685 | |
| (1) | The amounts reported in this column represent (i) $13,200 in Company
contributions made under our 401(k) plan and (ii) $2,835 in Company-paid life insurance premiums during the fiscal year ended
December 31, 2023 and, for the fiscal year ended December 31, 2022, (i) $9,400 in Company contributions made under our 401(k) plan
and (ii) $3,285 in Company-paid life insurance premiums. |
Narrative Disclosure to the 2023 Summary Compensation Table
Compensation of our named executive officer for
the fiscal year ended December 31, 2023 was determined and recommended by the compensation committee, and approved by the board of directors.
The compensation committee engaged a compensation consulting firm to provide and structure benchmarking data for similar positions in
similar companies.
2023 Base Salaries
The named executive officer’s base salary
is a fixed component of annual compensation for performing specific duties and functions. Dr. Corey’s base salary is adjusted from
time to time to realign with market levels after taking into account individual responsibilities, performance and experience. For the
fiscal year ended December 31, 2023, Dr. Corey’s annual base salary was $360,000.
Perquisites
We generally do not provide
perquisites to our employees, other than certain de minimis perquisites available to all of our employees, including our named executive
officers.
401(k) Plan
We maintain the CERo Therapeutics 401(k) Plan,
a tax-qualified retirement plan that provides eligible employees, including the named executive officer, with an opportunity to save for
retirement on a tax-advantaged basis. Plan participants are able to defer eligible compensation subject to applicable annual limits under
the Code. Participants’ pre-tax or Roth contributions are allocated to each participant’s individual account and are then
invested in selected investment alternatives according to the participants’ directions. Participants are immediately and fully vested
in their contributions. We match each participant’s contribution up to a safe harbor maximum of 4% of his or her eligible compensation
with participants vesting immediately and fully in such matching contributions. Our 401(k) plan is intended to be qualified under Section
401(a) of the Code with the 401(k) plan’s related trust intended to be tax exempt under Section 501(a) of the Code.
Health and Welfare Benefits
We provide benefits to our
named executive officer on the same basis as provided to all of its employees, including health, dental and vision insurance, as well
as life and disability insurance. Legacy CERo did not, and we will not, maintain any executive-specific benefit or perquisite programs.
Benefits were and are anticipated to be offered on the same basis as provided to all of our employees.
Outstanding Equity Awards as of December 31, 2023
There were no outstanding
equity incentive plan awards held by the named executive officer as of December 31, 2023.
Overview of Executive Compensation Program
Our Compensation Committee anticipates annually reviewing the compensation
of our employees, including our executive officers. In setting executive base salaries and bonuses and granting equity incentive awards,
the Compensation Committee considers compensation for comparable positions in the market, the historical compensation levels of our executive
officers, individual performance as compared to our expectations and objectives, internal equity, our desire to motivate our employees
to achieve short- and long-term results that are in the best interests of our stockholders, and a long-term commitment to us. We intend
to target a general competitive position and consider independent third-party benchmark analytics to determine the mix of compensation
of base salary, bonus and long-term incentives.
We engaged the services of an external compensation consultant to advise on
executive compensation matters including our overall compensation program design and collection of market data to inform our compensation
programs for our executive officers and members of our board of directors. The compensation for our executive officers will
have the following components: base salary, cash bonus opportunities, equity compensation, employee benefits, and severance protections.
Base salaries, employee benefits, and severance protections are designed to attract and retain senior management talent. Annual cash
bonuses and equity awards are used to promote performance-based pay that aligns the interests of the named executive officers with
the long-term interests of our stockholders and enhances executive retention.
Employment Arrangements
We are party to employment
agreements with each of our named executive officers. The arrangements generally provide for at-will employment without any specific term
and set forth the named executive officer’s initial base salary, bonus potential, eligibility for employee benefits and severance
benefits upon a qualifying termination of employment, subject to such employee executing a separation agreement with us.
Employment Agreement with Mr. Atwood
On March 26, 2024, we entered
into an employment agreement with Mr. Atwood, our Chairman and Chief Executive Officer the (“Atwood Employment Agreement”).
Pursuant to the Atwood Employment Agreement, Mr. Atwood is entitled to an initial annual base salary of $360,000, an initial target annual
incentive bonus of 50% of Mr. Atwood’s base salary, an initial equity grant, and general eligibility to participate in our employee
benefit plans.
The Atwood Employment Agreement
provides that in the event Mr. Atwood’s employment is terminated by us without “cause” (other than as a result of Mr.
Atwood’s death or disability) or by Mr. Atwood with “good reason” (each as defined in the Atwood Employment Agreement),
in either case within thirty days before or within twelve months following a “change in control” (as defined in the Atwood
Employment Agreement) (the “Atwood Change in Control Period”), then, Mr. Atwood will be entitled to: (1) a lump sum cash payment
equal to three months of his then-current base salary, and (2) full acceleration of the vesting of all his outstanding equity awards.
The Atwood Employment Agreement
provides that in the event Mr. Atwood’s employment is terminated by us without “cause” (other than as a result of Mr.
Atwood’s death or disability) or by Mr. Atwood for “good reason,” in either case, outside of the Atwood Change in Control
Period, then, Mr. Atwood will be entitled to a lump sum cash payment equal to three months of his then-current base salary.
The Atwood Employment Agreement
provides that in the event Mr. Atwood’s employment terminate as a result of Mr. Atwood’s death or disability, then, Mr. Atwood
will be entitled to accelerated vesting of 50% of the then-unvested portion of outstanding equity awards.
Mr. Atwood’s benefits
after termination (other than as a result of death or disability) are conditioned, among other things, on him timely signing and not revoking
a general release of claims in our favor.
The payments and benefits
under the Atwood Employment Agreement in connection with a change in control may not be eligible for federal income tax deduction by us
pursuant to Section 280G of the Code. These payments and benefits may also be subject to an excise tax under Section 4999 of the Code.
If the payments or benefits payable to Mr. Atwood in connection with a change in control would be subject to the excise tax imposed under
Section 4999 of the Code, then those payments or benefits will be reduced if such reduction would result in a higher net after-tax benefit
to him.
Employment Agreement with Mr. Carter
On March 26, 2024, we entered into an employment agreement with Mr.
Carter, our Chief Financial Officer and Corporate Secretary (the “Carter Employment Agreement”). Pursuant to the Carter Employment
Agreement, Mr. Carter is entitled to an initial base salary of $350,000 and an initial target annual incentive bonus of 35% of Mr. Carter’s
base salary, an initial equity grant, and general eligibility to participate in our employee benefit plans.
The Carter Employment Agreement
provides that in the event Mr. Carter’s employment is terminated by us without “cause” (other than as a result of Mr.
Carter’s death or disability) or by Mr. Carter with “good reason” (each as defined in the Carter Employment Agreement),
in either case within thirty days before or within twelve months following a “change in control” (as defined in the Carter
Employment Agreement) (the “Carter Change in Control Period”), then, Mr. Carter will be entitled to: (1) continued payment
of his then-current base salary for a period of twelve months following his termination, (2) if Mr. Carter timely elects COBRA health
continuation, payment of COBRA premiums for continued health benefits for up to twelve months following his termination for him and his
eligible dependents who were covered under the Company’s health insurance plans on the date of such termination, (3) his annual
target bonus for the year of termination, and (4) full acceleration of the vesting of all his outstanding equity awards.
The Carter Employment Agreement
provides that in the event Mr. Carter’s employment is terminated by us without “cause” (other than as a result of Mr.
Carter’s death or disability) or by Mr. Carter for “good reason,” in either case, outside of the Carter Change in Control
Period, then, Mr. Carter will be entitled to (1) continued payment of his then-current base salary for a period of nine months, and (2)
if Mr. Carter timely elects COBRA health continuation, payment of COBRA premiums for continued health benefits for up to nine months following
his termination for him and his eligible dependents who were covered under the Company’s health insurance plans on the date of such
termination.
The Carter Employment Agreement
provides that in the event Mr. Carter’s employment terminate as a result of Mr. Carter’s death or disability, then, Mr. Carter
will be entitled to accelerated vesting of 50% of the then-unvested portion of outstanding equity awards.
Mr. Carter’s benefits
after termination (other than as a result of death or disability) are conditioned, among other things, on him timely signing and not revoking
a general release of claims in our favor.
The payments and benefits
under the Carter Employment Agreement in connection with a change in control may not be eligible for federal income tax deduction by us
pursuant to Section 280G of the Code. These payments and benefits may also be subject to an excise tax under Section 4999 of the Code.
If the payments or benefits payable to Mr. Carter in connection with a change in control would be subject to the excise tax imposed under
Section 4999 of the Code, then those payments or benefits will be reduced if such reduction would result in a higher net after-tax benefit
to him.
Offer Letter with Dr. Corey
On March 28, 2024, we entered
into an employment agreement with Dr. Corey, our Chief Technology Officer and Founder of the Company the (“Corey Offer Letter”).
Pursuant to the Corey Offer Letter, Dr. Corey is entitled to an initial annual base salary of 350,000, an initial target annual incentive
bonus of 50% of Dr. Corey’s base salary, an initial equity grant, and general eligibility to participate in our employee benefit
plans.
The Corey Offer Letter provides
that in the event Dr. Corey’s employment is terminated by us without “cause” or by Dr. Corey for “good reason”
(each as defined in the Corey Offer Letter) within 90 days before or within twelve months following a “change in control”
(as defined in the Corey Offer Letter) (the “Corey Change in Control Period”), then Mr. Corey will be entitled to full acceleration
of the vesting of any options to purchase shares of the Company’s common stock that are subject to time-based vesting.
The Corey Offer Letter provides
that in the event Dr. Corey’s employment is terminated by us without “cause” or by Dr. Corey for “good reason,”
Dr. Corey will be entitled to: (1) the continued payment of his then-current base salary for a period of up to six months following his
termination, and (2) if Dr. Corey timely elects COBRA health continuation, payment of COBRA premiums for continued health benefits for
up to six months following his termination.
Dr. Corey’s benefits
after termination outside of the Corey Change in Control Period are conditioned, among other things, on him complying with his post-termination
obligations under his agreement, including a one-year non-solicitation obligation, and his timely signing a general release of claims
in our favor.
Annual Bonuses
We use annual cash
incentive bonuses for the named executive officers to motivate their achievement of short-term performance goals and tie a portion of
their cash compensation to performance. It is expected that, near the beginning of each year, the Compensation Committee will select the
performance targets, target amounts, target award opportunities and other terms and conditions of annual cash bonuses for the named executive
officers, subject to the terms of their employment agreements. Following the end of each year, the Compensation Committee will determine
the extent to which the performance targets were achieved and the amount of the award that is payable to each of the named executive officers.
There will be a bonus plan established for executive officers in 2024.
Director Compensation
None of our directors received
compensation in 2023 for services rendered to PBAX or Legacy CERo, with the exception of Dr. Corey, who was compensated for his service
as our Chief Executive Officer. Dr. Corey is a named executive officer and his compensation is provided in the “Summary Compensation
Table” above.
On March 25, 2024, the board
of directors approved the compensation for non-employee directors for 2024. Each non-employee director other than the vice chairman will
receive $30,000 per annum, paid quarterly in advance. In addition, each non-employee director other than the vice chairman shall receive
an option award to purchase 112,500 shares of common stock. Such option awards vest quarterly over a three-year period and expire ten
years after the grant date. The vice chairman will receive $150,000 per annum, paid quarterly in advance. In addition, the vice chairman
shall receive an option award to purchase 527,182 shares of common stock. Such option awards vest quarterly over a three-year period and
expire ten years after the grant date.
Mr. Atwood and Dr. Corey
will receive no additional compensation for their additional duties as directors. Mr. Atwood and Dr. Corey’s compensation is summarized
above in “Executive Compensation—Employment Agreements.”
Equity Incentive Compensation
We believe it is important to maintain a strong link between executive
incentives and the creation of stockholder value. We believe performance and equity-based compensation for our executives to be an important
component of maximizing stockholder value while, at the same time, attracting, motivating and retaining high-quality executives. Upon
consummation of the Business Combination, we assumed options issued pursuant to the CERo Therapeutics, Inc. 2016 Equity Incentive Plan,
as amended (the “2016 Plan”), and we currently maintain the CERo Therapeutics Holdings, Inc. 2024 Plan (the “2024 Plan”)
and the CERo Therapeutics Holdings, Inc. 2024 Employee Stock Purchase Plan (the “2024 ESPP”). Formal guidelines for the allocations
of cash and equity-based compensation have not yet been determined, but it is expected that the 2024 Plan, which was approved and adopted
by stockholders on January 22, 2024, will be an important element of our compensation arrangements for both executive officers and directors,
and that the executive officers will also be eligible to participate in the 2024 ESPP, which was also approved and adopted by stockholders
on January 22, 2024.
As of December 31, 2023,
the 2016 Plan had options outstanding to purchase a total of 782,499 shares of common stock for a weighted average exercise price of $0.28
per share. On February 14, 2024, upon consummation of the Business Combination, these options were assumed by us and converted into options
to purchase shares in CERo at a conversion rate of 0.064452 underlying shares per legacy share and a strike
price calculated as the legacy strike price divided by 0.064452. This resulted in the issuance of options to purchase 50,433 shares of
common stock at a weighted average price of $4.36.
On March 25, 2024, the board of directors approved option awards to
the executive officers for 2024, as set forth below:
Name | |
Position | |
Option Awards | |
Brian G. Atwood | |
Chairman, President, and Chief Executive Officer | |
| 1,317,956 | |
Charles Carter | |
Chief Financial Officer, Treasurer and Corporate Secretary | |
| 395,387 | |
Daniel Corey, M.D. | |
Chief Technology Officer and Founder | |
| 856,671 | |
Compensation Recovery Policy
Our board of directors adopted a Compensation Recovery
Policy (the “Compensation Recovery Policy”), in compliance with the Nasdaq listing rules, which requires recovery from executive
officers of incentive-based compensation that is earned, granted or vested based on the achievement of a financial reporting measure in
the event of a required accounting restatement of previously issued financial statements. The recoverable compensation includes any compensation
received after the effective date of the Compensation Recovery Policy and in the three-year fiscal period preceding the date we were required
to prepare the accounting restatement that is in excess of the amount that would have been earned, paid or vested had it been calculated
based on the restated financial statements. Recovery is required regardless of fault or a covered officer’s role in the financial reporting
process. The Compensation Recovery Policy is filed as Exhibit 97.1 to this Annual Report on Form 10-K for the year ended December 31,
2023.
Rule 10b5-1 Sales Plans
Our directors and executive
officers may adopt written plans, known as Rule 10b5-1 plans, in which they will contract with a broker to buy or sell shares of
common stock on a periodic basis. Under a Rule 10b5-1 plan, a broker executes trades pursuant to parameters established by the director
or executive officer when entering into the plan, without further direction from them. The director or executive officer may amend a Rule 10b5-1
plan in some circumstances and may terminate a plan at any time. Our directors and executive officers also may buy or sell additional
shares outside of a Rule 10b5-1 plan when they are not in possession of material nonpublic information, subject to compliance with
the terms of the insider trading policy.
Item 12. Security Ownership of Certain Beneficial
Owners and Management Related Stockholder Matters.
Security Ownership of Certain Beneficial Owners
The following table sets forth information regarding the beneficial
ownership of our common stock as of April 1, 2024, by:
| ● | each person known by us to be the beneficial owner of more
than 5% of our outstanding shares of Common Stock; |
| ● | each of our named executive officers and directors that beneficially
owns shares of our Common Stock; and |
| ● | all our executive officers and directors as a group. |
Beneficial
ownership is determined in accordance with the rules and regulations of the SEC, which generally provide that a person has beneficial
ownership of a security if he, she or it possesses sole or shared voting or investment power over that security. Shares of our Common
Stock subject to options or warrants that are currently exercisable or exercisable within 60 days or shares of Common Stock underlying
time-based restricted stock units that vest within 60 days are considered outstanding and beneficially owned by the person holding the
options, warrants, or restricted stock units, as applicable, for the purpose of calculating the percentage ownership of that person but
not for the purpose of calculating the percentage ownership of any other person. Unless otherwise indicated, we believe that the persons
and entities named in the table below have sole voting and investment power with respect to all of our voting securities beneficially
owned by them. Unless otherwise indicated, we believe that all persons named in the table have sole voting and investment power
with respect to all shares of Common Stock beneficially owned by them.
The percentage of beneficial
ownership is based on 14,723,565 shares of common stock issued and outstanding as of April 1, 2024.
Name of Beneficial Owner (1) | |
Number of Shares Beneficially Owned | | |
Percentage Beneficially Owned | |
5% or Greater Beneficial Owners: | |
| | |
| |
Phoenix Biotech Sponsor, LLC (2) | |
| 1,000,000 | | |
| 6.8 | % |
Milky Way Investments Group
Limited(3) | |
| 1,503,540 | | |
| 10.21 | % |
ARCH Venture Fund X, L.P.(4) | |
| 1,359,196 | | |
| 9.23 | % |
Launchpad Capital Opportunities
Fund LP (Series SPAC) (5) | |
| 1,430,989 | | |
| 9.72 | % |
Directors and Executive Officers: | |
| | | |
| | |
Brian G. Atwood (6) | |
| 692,278 | | |
| 4.2 | % |
Charles Carter (7) | |
| 5,000 | | |
| * | |
Daniel Corey, M.D.(8) | |
| 1,081,857 | | |
| 6.6 | % |
Michael Byrnes | |
| — | | |
| — | |
Chris Ehrlich (9) | |
| 514,925 | | |
| 3.5 | % |
Kathleen LaPorte (10) | |
| 10,828 | | |
| * | |
Robyn Rapaport (11) | |
| 50,000 | | |
| * | |
Lindsey Rolfe, M.D., Ph.D. | |
| — | | |
| — | |
All current directors and executive officers as a group (seven individuals) | |
| 1,630,088 | | |
| 11.1 | % |
* | Represents beneficial ownership of less than 1% of our outstanding
Common Stock. |
(1) | Unless otherwise noted, the business address of each of the following individuals is 210 Haskins Way,
Suite 230, South San Francisco, CA 94080. |
(2) | Consists of 1,000,000 shares of Common Stock. The Sponsor is the
record holder of the shares reported herein. Jurgen van de Vyver is the manager of the Sponsor and has voting and investment discretion
with respect to the Common Stock held by the Sponsor. Mr. Vyver may be deemed to have beneficial ownership of the Common Stock held directly
by the Sponsor. The principal business address of such entities and individuals is 2201 Broadway,
Suite 705, Oakland, CA 94612. |
(3) | Consists of 1,503,540 shares of Common Stock. Milky Way Investments
Group Limited (“Milky Way”) is controlled by MWG Management Limited, its corporate director. The principal business
address of such entities and individuals is c/o Trident Trust Company (B.V.I.) Limited, Trident
Chambers, P.O. Box 146, Road Town, Tortola, British Virgin Islands. |
(4) | Consists of 1,359,196 shares of Common Stock. ARCH Venture
Partners X, L.P. (“AVP X LP”) is the sole general partner of ARCH X. ARCH Venture Partners X Overage, L.P. (“AVP X Overage
LP”) is the sole general partner of ARCH X Overage. ARCH Venture Partners XII, L.P. (“AVP XII LP”) is the general partner
of ARCH XII. ARCH Venture Partners X, LLC (“AVP X LLC”) is the sole general partner of each of AVP X LP and AVP X Overage
LP. Keith Crandell, Kristina Burow, Steven Gillis and Robert Nelsen comprise the investment committee of AVP X LLC (the “AVP X Committee
Members”). AVP X LLC may be deemed to beneficially own the shares held by ARCH X and ARCH X Overage, and each of the AVP X Committee
Members may be deemed to share the power to direct the disposition and vote of the shares held by ARCH X and ARCH X Overage. The principal
business address of such entities and individuals is 8755 West Higgins Road, Suite 1025. Chicago, IL 60631. |
(5) | Consists of (i) 1,165,991 shares of Common Stock and (ii) 264,998 shares
of Common Stock issuable upon the exercise of Warrants exercisable within 60 days of April 1, 2024. Ryan Gilbert is the general partner
of Launchpad Capital Opportunities Fund LP (Series SPAC) (“Launchpad”). The principal business address of such entities and
individuals is 2201 Broadway, Suite 705, Oakland, CA 94612. |
(6) | Consists of (i) 248,735 shares of Common Stock, including 21,219 Earnout
Shares, which are subject to vesting upon the achievement of certain milestones, (ii) 343,343 shares of Common Stock issuable pursuant
to stock options exercisable within 60 days of April 1, 2024 and (iii) 100,200 shares of Common Stock issuable upon the conversion of
Series A Preferred Stock (assuming an initial conversion price of $10.00 per share), held by the Atwood-Edminister Trust dtd 4-2-2000,
of which Mr. Atwood serves as a trustee. |
(7) | Consists of 5,000 shares of Common Stock issuable upon the conversion of Series A Preferred Stock (assuming
an initial conversion price of $10.00 per share). |
(8) | Consists of (i) 660,454 shares of Common Stock, including 230,973 Earnout Shares, which are subject to
vesting upon the achievement of certain milestones, held by Daniel Corey, (ii) 3,672 shares of Common Stock, including 273 Earnout Shares,
which are subject to vesting upon the achievement of certain milestones, held by his spouse, Elizabeth Corey, (iii) 3,672 shares of Common
Stock, including 273 Earnout Shares, which are subject to vesting upon the achievement of certain milestones, held by Daniel Corey as
legal guardian of Hannah Corey, a minor child and (iv) 3,672 shares of Common Stock, including 273 Earnout Shares, which are subject to
vesting upon the achievement of certain milestones, held by Daniel Corey as legal guardian of Griffin Corey, a minor child. |
(9) | Consists of (i) 478,825 shares of Common Stock, (ii) 27,500 shares
of Common Stock issuable upon the conversion of Series A Preferred Stock (assuming an initial conversion price of $10.00 per share) (iii)
5,000 shares of Common Stock issuable upon the exercise of Warrants exercisable within 60 days of April 1, 2024, and (iv) 3,600 shares
of Common Stock held by his spouse, Sara Fried. |
(10) | Consists of (i) 5,828 shares of Common Stock held by Kathleen LaPorte and (ii) 27,500 shares of Common
Stock issuable upon the conversion of Series A Preferred Stock (assuming an initial conversion price of $10.00 per share) held by Kathleen
LaPorte Revocable Trust, of which Ms. LaPorte serves as a trustee. |
(11) | Consists of 50,000 shares of Common Stock. |
Equity
Compensation Plan Information
The following table sets
forth information as of December 31, 2023 regarding shares of Common Stock that may be issued under our equity compensation plans.
Such information includes equity compensation plans of Legacy CERo as of December 31, 2023 that were assumed by the Company in the Business
Combination:
Plan Category | |
Number of Securities to be Issued Upon Exercise of Outstanding Options, Warrants and Rights | | |
Weighted- average Exercise Price of Outstanding Options, Warrants, Rights | | |
Number of Securities Remaining Available for Future Issuance Under Equity Compensation Plans | |
Equity compensation plans approved by stockholders | |
| — | | |
$ | — | | |
| — | |
Equity compensation plans not approved by stockholders | |
| 782,499 | (1) | |
| 0.28 | (2) | |
| — | |
| |
| | | |
| | | |
| | |
Total | |
| 782,499 | | |
$ | 0.28 | | |
| — | |
(1) |
Includes 50,433 shares subject to outstanding stock options under the 2016 Plan that were outstanding on December 31, 2023 (presented on an as-converted basis). No new awards may be granted under the 2016 Plan. |
(2) |
Reflects the weighted-average exercise price of the $4.19 outstanding stock options under the 2016 Plan, presented on an as-converted basis. |
(3) |
Does not reflect shares reserved and available for issuance under the 2024 Plan or 2024 ESPP, as such plans were not in effect as of December 31, 2023. On February 8, 2024, the stockholders approved the 2024 Plan and 2024 ESPP, with an initial reserve of 5,271,822 and 527,182 shares of common stock, respectively. The 2024 Plan and 2024 ESPP became effective on February 14, 2024 in connection with the closing of the Business Combination. As of March 31, 2024, the board of directors have granted an aggregate of 4,588,619 option awards under the 2024 Plan, leaving 683,204 shares reserved for future issuance under the 2024 Plan. As of March 31, 2024, no awards have been granted under the 2024 ESPP. No new awards may be granted under the 2016 Plan, but all outstanding awards under the 2016 Plan continue to be governed by their existing terms. The 2024 Plan has an evergreen provision that allows for an annual increase in the number of shares available for issuance under the 2024 Plan to be added on the first day of January, starting with January 1, 2025, in an amount equal to the lesser of (i) 5% of the fully diluted shares of our common stock on the immediately preceding December 31 or (ii) such number of shares as determined by our board in each case subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization. The 2024 ESPP has an evergreen provision that allows for an annual increase in the number of shares available for issuance under the 2024 ESPP to be added on the first day of each January, starting with January 1, 2024, by the lesser of (i) 1,019,850 shares of our common stock, (ii) 1% of the fully diluted shares of common stock on the immediately preceding December 31, or (iii) such number of shares of common stock as determined by our board. The number of shares reserved under the 2023 ESPP is subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization. |
Item 13. Certain Relationships and Related
Party Transactions, and Director Independence.
Certain Relationships and Transactions
Other than the compensation
agreements and other arrangements described under the sections entitled “Executive Compensation” and “Director
Compensation” above and the transactions described below, since January 1, 2022, there has not been and there is not currently
proposed, any transaction or series of similar transactions to which we were, or will be, a party in which:
| ● | the amount involved exceeded, or will exceed, $120,000 (or,
if less, 1% of the average of our total asset amounts at December 31, 2022 and 2023); and |
| ● | any director, executive officer,
holder of 5% or more of any class of our capital stock or any member of the immediate family of, or entities affiliated with, any of
the foregoing persons, had, or will have, a direct or indirect material interest. |
PBAX Relationships and Related Party Transactions
Related Party Loans
In order to finance transaction
costs in connection with the Business Combination, the Sponsor or an affiliate of the Sponsor or certain of PBAX’s officers and
directors may, but are not obligated to, to loan PBAX funds as may be required. On December 13, 2022, PBAX issued an unsecured promissory
note in the principal amount of $1,500,000 (the “Promissory Note”) to the Sponsor, pursuant to which the Sponsor agreed to
loan to the PBAX up to $1,500,000. On December 8, 2023, the Promissory Note was amended to increase the total principal amount to
$1,600,000. At the Closing, an aggregate of approximately $1.55 million that had been borrowed under the Promissory Note was extinguished
and converted into an aggregate of 1,330 shares of Series A Preferred Stock and 50 shares of Series B Preferred Stock.
Administrative Services
Commencing on October 6,
2021, PBAX paid an amount equal to $20,000 per month to the Sponsor or its affiliate or designee for office space, administrative and
shared personnel support services provided to PBAX. Such administrative support services ended on December 31, 2022.
Advisory Services
We engaged CCM, an affiliate of PBAX, the Sponsor and/or
certain of its directors and officers, to provide consulting and advisory services in connection with the IPO, for which it was entitled
to a fee in an amount equal to $465,000, which was paid to CCM upon the closing of the IPO, and $1,162,500, which would have been paid
to CCM upon the Closing. In connection with the Closing, PBAX entered into a fee modification agreement with CCM pursuant to which CCM
forfeited such fees and we issued an aggregate of 1,200,000 shares of Common Stock, with 1,000,000 of such shares being subject to forfeiture
unless we conduct a capital-raising transaction within nine months of the Closing, pursuant to which we shall issue and sell securities
in an aggregate amount of at least $25.0 million, affiliates of CCM have and manage investment vehicles with a passive investment in the
Sponsor.
CERo Relationships and Related Party Transactions
Collaboration and Option Agreement
On March 3, 2020, Legacy
CERo entered into a collaboration and option agreement (“Collaboration Agreement”) with a collaborative partner that was an
investor of Legacy CERo, pursuant to which each party was granted a royalty-free, nonexclusive, worldwide license to share the other party’s
technologies to create bi-functional T-cells. Legacy CERo was responsible for all employee and other internal costs incurred in the
performance of all of Legacy CERo’s R&D activities, with approved cost overruns funded by the collaborative partner. At the
end of the research project, the collaborative partner would be granted the option to enter into an exclusive license for the further
development of the combined drug. Under the Collaboration Agreement, the collaborative partner paid us $182,577 and $0 for the years ended
December 31, 2022 and 2023. The Collaboration Agreement terminated on March 3, 2023.
Policies and Procedures for Related Party Transactions
We have adopted a code of
conduct and ethics requiring us to avoid, wherever possible, all conflicts of interests, except under guidelines or resolutions approved
by the board of directors (or the appropriate committee of the board of directors) or as disclosed in public filings with the SEC. Under
the adopted code of conduct and ethics, conflict of interest situations include any financial transaction, arrangement or relationship
(including any indebtedness or guarantee of indebtedness) involving us.
In addition, pursuant to
the Audit Committee charter, our Audit Committee is responsible for reviewing and approving related party transactions to the extent that
we entered into such transactions. An affirmative vote of a majority of the members of the Audit Committee present at a meeting at which
a quorum is present will be required in order to approve a related party transaction. Without a meeting, the unanimous written consent
of all of the members of the Audit Committee will be required to approve a related party transaction. We also require each of our directors
and officers to complete a directors’ and officers’ questionnaire that elicits information about related party transactions.
These procedures are intended to determine whether any such related party transaction impairs the independence of a director or presents
a conflict of interest on the part of a director, employee or officer.
Our Audit Committee reviews
on a quarterly basis all payments that were made to the officers or directors, or to their affiliates.
Item 14. Principal Accountant Fees and Services.
Our
independent public accounting firm is Citrin Cooperman & Company, LLP (“Citrin”),
New York, New York (PCAOB Auditor ID: 02468). Citrin has acted as PBAX’s independent registered public accounting firm since
June 8, 2021 (inception). The following table sets forth the aggregate fees and expenses billed to us by Citrin for fiscal years
2023 and 2022:
Fee category | |
2023 | | |
2022 | |
Audit fees (1) | |
| 155,400 | | |
| 50,000 | |
Tax fees (2) | |
| 9,660 | | |
| 4,000 | |
All other fees | |
| — | | |
| — | |
Total | |
| 158,175 | | |
| 54,000 | |
(1) | Audit fees consist of fees for professional services rendered for the audit of our year-end consolidated
financial statements and services that are normally provided by our independent registered public accounting firm in connection with regulatory
filings, and other fees in connection with the Business Combination. |
(2) | Tax fees consist of fees for tax consultation services for the Business Combination and professional services
relating to tax compliance, tax planning, and tax advice. |
Pre-Approval Policies and Procedures
Our Audit Committee established
a policy that all audit and permissible non-audit services provided by the independent registered public accounting firm will be pre-approved
by the Audit Committee, and all such services were pre-approved in accordance with this policy during the fiscal year ended December 31,
2023. These services included audit services, audit-related services, tax services and other services. The Audit Committee considered
whether the provision of each non-audit service were compatible with maintaining the independence of the auditors. Pre-approval was detailed
as to the particular service or category of services and was generally subject to a specific budget. Our independent registered public
accounting firm and management were required to periodically report to the Audit Committee regarding the extent of services provided by
the independent registered public accounting firm in accordance with this pre-approval, and the fees for the services performed to date.
PART IV
Item 15. Exhibit and Financial Statement Schedules.
| (1) | For a list of the financial statements included herein, see
Index to the Consolidated Financial Statements on page F-1 of this Annual Report, incorporated into this Item by reference. |
| (2) | Financial statement schedules have been omitted because they
are either not required or not applicable or the information is included in the consolidated financial statements or the notes thereto. |
The following list of exhibits
includes exhibits submitted with this Annual Report as filed with the SEC and those incorporated by reference to other filings.
Exhibit No. |
|
Description |
2.1 |
|
Business Combination Agreement, dated as of June 4, 2023, by and among Phoenix Biotech Acquisition Corp., PBCE Merger Sub, Inc. and CERo Therapeutics, Inc., as amended (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by Phoenix Biotech Acquisition Corp. with the Securities and Exchange Commission on June 5, 2023). |
2.2 |
|
Amendment No. 1 to the Business Combination Agreement, dated as of February 5, 2024, by and among Phoenix Biotech Acquisition Corp., PBCE Merger Sub, Inc. and CERo Therapeutics, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by Phoenix Biotech Acquisition Corp. with the Securities and Exchange Commission on February 6, 2024). |
2.3 |
|
Amendment No. 2 to the Business Combination Agreement, dated as of February 13, 2024, by and among Phoenix Biotech Acquisition Corp., PBCE Merger Sub, Inc. and CERo Therapeutics, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by Phoenix Biotech Acquisition Corp. with the Securities and Exchange Commission on February 13, 2024). |
3.1 |
|
Second Amended and Restated Certificate of Incorporation of CERo Therapeutics Holdings, Inc. (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
3.2 |
|
Second Amended and Restated Bylaws of CERo Therapeutics Holdings, Inc. (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
3.3 |
|
Certificate of Designation of Preferences, Rights and Limitations of the Series A Convertible Preferred Stock (incorporated by reference to Exhibit 3.3 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
3.4 |
|
Certificate of Correction to Certificate of Designation of Preferences, Rights and Limitations of the Series A Convertible Preferred Stock (incorporated by reference to Exhibit 3.4 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
3.5 |
|
Second Certificate of Correction to Certificate of Designation of Preferences, Rights and Limitations of the Series A Convertible Preferred Stock (incorporated by reference to Exhibit 3.5 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
3.6* |
|
Certificate of Designation of Preferences, Rights and Limitations of the Series B Convertible Preferred Stock. |
4.1 |
|
Warrant Agreement, by and between Phoenix Biotech Acquisition Corp. and Continental Stock Transfer & Trust Company, dated October 5, 2021 (incorporated by reference to Exhibit 4.1 to the Registration Statement on Form S-1 filed by Phoenix Biotech Acquisition Corp. with the Securities and Exchange Commission on September 13, 2021). |
4.2 |
|
Form of Common Warrant (incorporated by reference to Exhibit 4.2 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
4.3 |
|
Form of Preferred Warrant (incorporated by reference to Exhibit 4.3 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
4.5* |
|
Description of Securities. |
10.1+ |
|
CERo Therapeutics, Inc. 2016 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.1 to the Registration Statement on Form S-4/A filed by Phoenix Biotech Acquisition Corp. with the Securities and Exchange Commission on June 7, 2023). |
10.2+ |
|
CERo Therapeutics Holdings, Inc. 2024 Equity Incentive Plan (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.3+ |
|
CERo Therapeutics Holdings, Inc. 2024 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.3 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.4 |
|
Form of Indemnification Agreement, by and between Phoenix Biotech Acquisition Corp. and each of its directors and executive officers (incorporated by reference to Exhibit 10.4 to the Registration Statement on Form S-4/A filed by Phoenix Biotech Acquisition Corp. with the Securities and Exchange Commission on December 18, 2023). |
10.5 |
|
Investor Rights and Lock-Up Agreement, dated February 14, 2024, by and between Phoenix Biotech Acquisition Corp. and the parties named therein (incorporated by reference to Exhibit 10.5 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.6 |
|
Amended and Restated Securities Purchase Agreement, dated as of February 14, 2024, by and between Phoenix Biotech Acquisition Corp., CERo Therapeutics, Inc. and the investors named therein (incorporated by reference to Exhibit 10.6 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.7 |
|
Registration Rights Agreement, dated as of February 14, 2024, by and between Phoenix Biotech Acquisition Corp., CERo Therapeutics, Inc. and the investors named therein (incorporated by reference to Exhibit 10.7 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.8 |
|
Common Stock Purchase Agreement, dated as of February 14, 2024, by and between CERo Therapeutics Holdings, Inc. and Keystone Capital Partners, LLC (incorporated by reference to Exhibit 10.8 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.9 |
|
Registration Rights Agreement, dated as of February 14, 2024, by and between CERo Therapeutics Holdings, Inc. and the Lead Investor (incorporated by reference to Exhibit 10.9 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.10 |
|
Form of Share Reallocation Agreement, dated as of February 14, 2024, by and among Phoenix Biotech Acquisition Corp., Phoenix Biotech Sponsor, LLC and the parties named therein (incorporated by reference to Exhibit 10.10 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.11 |
|
Letter Agreement, dated as of February 14, 2024, by and between Phoenix Biotech Sponsor, LLC and CERo Therapeutics Holdings, Inc. (incorporated by reference to Exhibit 10.11 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.12 |
|
Side Letter, dated as of February 14, 2024, by and between Phoenix Biotech Acquisition Corp. and the Lead Investor (incorporated by reference to Exhibit 10.12 to the Current Report on Form 8-K/A filed by CERo Therapeutics Holdings, Inc. with the Securities and Exchange Commission on February 27, 2024). |
10.13* |
|
Securities Purchase Agreement, dated as of March 29, 2024, by and between CERo Therapeutics Holdings, Inc. and the investors named therein. |
10.14* |
|
Registration Rights Agreement, dated as of March 29, 2024, by and between CERo Therapeutics Holdings, Inc. and the investors party thereto. |
10.15+* |
|
Employment Agreement, dated as of March 26, 2024, by and between CERo Therapeutics Holdings, Inc. and Brian Atwood. |
10.16+* |
|
Employment Agreement, dated as of March 28, 2024, by and between CERo Therapeutics Holdings, Inc. and Charles Carter. |
10.17+* |
|
Offer Letter, dated as of March 28, 2024, by and between CERo Therapeutics Holdings, Inc. and Daniel Corey. |
* |
Filed herewith. |
+ |
Indicates management contract or compensatory plan. |
† |
Portions of this exhibit (indicated by [***]) have been omitted because the registrant has determined that the information is both not material and is the type that the registrant treats as private and confidential. |
# |
The certifications furnished in Exhibit 32.1 hereto are deemed to accompany this report and will not be deemed “filed” for purposes of Section 18 of the Exchange Act. Such certifications will not be deemed to be incorporated by reference into any filings under the Securities Act or the Exchange Act, except to the extent that the registrant specifically incorporates it by reference. |
Item 16. Form 10-K Summary.
None.
SIGNATURES
Pursuant to the requirements of the Securities
Exchange Act of 1934, as amended, the registrant has duly caused this Annual Report on Form 10-K to be signed on its behalf by the undersigned,
thereunto duly authorized.
|
CERO THERAPEUTICS HOLDINGS, INC. |
|
|
Date: April 2, 2024 |
By: |
/s/ Brian G. Atwood |
|
|
Brian G. Atwood |
|
|
Chairman, Chief Executive Officer and Director |
|
|
(Principal Executive Officer) |
|
|
|
Date: April 2, 2024 |
By: |
/s/ Charles R. Carter |
|
|
Charles R. Carter |
|
|
Chief Financial Officer, Treasurer and Secretary |
|
|
(Principal Financial and Accounting Officer) |
POWER OF ATTORNEY
KNOW
ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints each of Brian G. Atwood and Charles
R. Carter his or her true and lawful attorney-in-fact and agent, with full power of substitution, for him or her and in his or her name,
place and stead, in any and all capacities, to sign any and all amendments to this Annual Report on Form 10-K, and to file the same, with
all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact
and agent, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith,
as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact
and agent, or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant
to the requirements of the Securities Exchange Act of 1934, as amended, this Annual Report on Form 10-K has been signed below by the following
persons on behalf of the Registrant in the capacities and on the dates indicated.
Name |
|
Title |
|
Date |
|
|
|
|
|
/s/ Brian G. Atwood |
|
Chairman, Chief Executive Officer and Director |
|
April 2, 2024 |
Brian G. Atwood |
|
(Principal Executive Officer) |
|
|
|
|
|
|
|
/s/ Charles R. Carter |
|
Chief Financial Officer, Treasurer and Secretary |
|
April 2, 2024 |
Charles R. Carter |
|
(Principal Financial and Accounting Officer) |
|
|
|
|
|
|
|
/s/ Chris Ehrlich |
|
Vice Charmain of the Board |
|
April 2, 2024 |
Chris Ehrlich |
|
|
|
|
|
|
|
|
|
/s/ Michael Byrnes |
|
Director |
|
April 2, 2024 |
Michael Byrnes |
|
|
|
|
|
|
|
|
|
/s/ Daniel Corey |
|
Director |
|
April 2, 2024 |
Daniel Corey |
|
|
|
|
|
|
|
|
|
/s/ Kathleen LaPorte |
|
Director |
|
April 2, 2024 |
Kathleen LaPorte |
|
|
|
|
|
|
|
|
|
/s/ Robyn Rapaport |
|
Director |
|
April 2, 2024 |
Robyn Rapaport |
|
|
|
|
|
|
|
|
|
/s/ Lindsey Rolfe |
|
Director |
|
April 2, 2024 |
Lindsey Rolfe |
|
|
|
|
PHOENIX
BIOTECH ACQUISITION CORP.
INDEX
TO FINANCIAL STATEMENTS
REPORT
OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
To
the Stockholders and Board of Directors of Phoenix Biotech Acquisition Corp.
Opinion
on the Financial Statements
We have audited the accompanying balance sheets of Phoenix Biotech
Acquisition Corp. (the “Company”) as of December 31, 2023 and 2022, and the related statements of operations, changes in stockholders’
deficit and cash flows for each of the years in the two-year period ended December 31, 2023, and the related notes (collectively, the
“financial statements”). In our opinion, the financial statements present fairly, in all material respects, the financial
position of the Company as of December 31, 2023 and 2022, and the results of its operations and its cash flows for each of the years in
the two-year period ended December 31, 2023, in conformity with accounting principles generally accepted in the United States of America.
Substantial Doubt About the Company’s Ability to Continue
as a Going Concern
The accompanying financial statements have been
prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the financial statements, the Company’s
expected working capital needs to fund its combined operations and meet obligations as a result of the acquisition of CERo Therapeutics,
Inc. in February 2024, raise substantial doubt about its ability to continue as a going concern. The Company’s continued operations
are dependent upon its ability to raise additional funds through debt or equity financing. There can be no assurances that the Company
will be able to secure any such additional financing on acceptable terms and conditions, or at all. Management’s plan in regard
to these matters is described in Note 1. The financial statements do not include any adjustments that might result from the outcome of
this uncertainty.
Basis
for Opinion
These
financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s
financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board
(United States) (“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal
securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.
We
conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audits to obtain
reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company
is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits,
we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion
on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.
Our
audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error
or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding
the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant
estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits
provide a reasonable basis for our opinion.
/s/
Citrin Cooperman & Company, LLP
We
have served as the Company’s auditor since 2021.
New
York, New York
April 2, 2024
PHOENIX
BIOTECH ACQUISITION CORP.
BALANCE
SHEETS
| |
December
31, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
ASSETS | |
| | |
| |
| |
| | |
| |
CURRENT
ASSETS | |
| | |
| |
Cash | |
$ | 96,873 | | |
$ | 475,870 | |
Prepaid
expenses and other assets | |
| 27,426 | | |
| 225,188 | |
Money
market funds held in Trust Account | |
| 8,436,311 | | |
| — | |
Restricted
cash held in Trust Account | |
| — | | |
| 41,665,974 | |
TOTAL
ASSETS | |
$ | 8,560,610 | | |
$ | 42,367,032 | |
| |
| | | |
| | |
LIABILITIES,
REDEEMABLE COMMON STOCK, AND STOCKHOLDERS’ DEFICIT | |
| | | |
| | |
CURRENT
LIABILITIES | |
| | | |
| | |
Accounts
payable and accrued expenses | |
$ | 3,535,084 | | |
$ | 1,653,120 | |
Income
tax payable | |
| 23,633 | | |
| 599,159 | |
Shareholder
redemption liability | |
| — | | |
| 27,842,747 | |
Working
capital loan – related party | |
| 1,555,000 | | |
| 650,000 | |
Excise
tax payable | |
| 56,389 | | |
| — | |
Due
to Affiliate | |
| 3,315 | | |
| 3,315 | |
Total
current liabilities | |
| 5,173,421 | | |
| 30,748,341 | |
LONG
TERM LIABILITIES | |
| | | |
| | |
Deferred
underwriting fee payable | |
| 9,150,000 | | |
| 9,150,000 | |
Total
liabilities | |
| 14,323,421 | | |
| 39,898,341 | |
| |
| | | |
| | |
COMMITMENTS
AND CONTINGENCIES | |
| | | |
| | |
REDEEMABLE
COMMON STOCK | |
| | | |
| | |
Class A Common stock subject to possible redemption, $0.0001 par value, 764,957 and 1,288,298 shares at redemption value of $11.03 and $10.26 per share as of December 31, 2023 and 2022, respectively | |
| 8,436,311 | | |
| 13,468,845 | |
STOCKHOLDERS’
DEFICIT | |
| | | |
| | |
Preferred stock, $0.0001 par value; 1,000,000 shares authorized; none issued or outstanding | |
| — | | |
| — | |
Class A common stock; $0.0001 par value; 60,000,000 shares authorized; 5,481,250 and 885,000 shares issued and outstanding (excluding 764,957 and 1,288,298 shares subject to possible redemption) as of December 31, 2023 and 2022, respectively | |
| 547 | | |
| 88 | |
Class B common stock; $0.0001 par value; 10,000,000 shares authorized; 0 and 4,596,250 shares issued and outstanding as of December 31, 2023 and 2022, respectively | |
| — | | |
| 459 | |
Additional
paid-in capital | |
| — | | |
| — | |
Accumulated
deficit | |
| (14,199,669 | ) | |
| (11,000,701 | ) |
Total
stockholders’ deficit | |
| (14,199,122 | ) | |
| (11,000,154 | ) |
TOTAL
LIABILITIES, REDEEMABLE COMMON STOCK, AND STOCKHOLDERS’ DEFICIT | |
$ | 8,560,610 | | |
$ | 42,367,032 | |
The
accompanying notes are an integral part of the financial statements.
PHOENIX
BIOTECH ACQUISITION CORP.
STATEMENTS
OF OPERATIONS
| |
For the Year Ended December 31, | |
| |
2023 | | |
2022 | |
OPERATING EXPENSES | |
| | |
| |
General and administrative | |
$ | 2,892,935 | | |
$ | 2,841,391 | |
Franchise tax | |
| 40,050 | | |
| 64,050 | |
Loss from operations | |
| (2,932,985 | ) | |
| (2,905,441 | ) |
| |
| | | |
| | |
Other income: | |
| | | |
| | |
Interest income earned on marketable securities held in Trust Account | |
| 491,571 | | |
| 2,836,864 | |
Total other income | |
| 491,571 | | |
| 2,836,864 | |
| |
| | | |
| | |
Loss before provision for income taxes | |
| (2,441,414 | ) | |
| (68,577 | ) |
Provision for income taxes | |
| (94,819 | ) | |
| (599,159 | ) |
Net loss | |
$ | (2,536,233 | ) | |
$ | (667,736 | ) |
| |
| | | |
| | |
Weighted average shares outstanding of Class A common stock | |
| 4,224,247 | | |
| 17,896,428 | |
Basic and diluted net loss per share, Class A common stock | |
$ | (0.39 | ) | |
$ | (0.03 | ) |
| |
| | | |
| | |
Weighted average shares outstanding of Class B common stock | |
| 2,304,421 | | |
| 4,596,250 | |
Basic and diluted net loss per share, Class B common stock | |
$ | (0.39 | ) | |
$ | (0.03 | ) |
The
accompanying notes are an integral part of the financial statements.
PHOENIX
BIOTECH ACQUISITION CORP.
STATEMENTS
OF CHANGES IN STOCKHOLDERS’ DEFICIT
FOR
THE YEAR ENDED DECEMBER 31, 2023 AND 2022
| |
Common
stock | | |
Additional | | |
| | |
Total | |
| |
Class A | | |
Class B | | |
paid-in | | |
Accumulated | | |
Stockholders’ | |
| |
Shares | | |
Amount | | |
Shares | | |
Amount | | |
capital | | |
deficit | | |
Deficit | |
Balance,
December 31, 2021 | |
| 885,000 | | |
$ | 88 | | |
| 4,596,250 | | |
$ | 459 | | |
$ | — | | |
$ | (7,670,412 | ) | |
$ | (7,669,865 | ) |
Accretion
for Class A Common Stock Subject to Redemption | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| (2,662,553 | ) | |
| (2,662,553 | ) |
Net
loss | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| (667,736 | ) | |
| (667,736 | ) |
Balance,
December 31, 2022 | |
| 885,000 | | |
| 88 | | |
| 4,596,250 | | |
| 459 | | |
| — | | |
| (11,000,701 | ) | |
| (11,000,154 | ) |
Accretion
for Class A Common Stock Subject to Redemption | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| (606,346 | ) | |
| (606,346 | ) |
Excise
tax liability accrued for Class A common stock redemptions | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| (56,389 | ) | |
| (56,389 | ) |
Conversion
of Class B common stock to Class A common stock | |
| 4,596,250 | | |
| 459 | | |
| (4,596,250 | ) | |
| (459 | ) | |
| — | | |
| — | | |
| — | |
Net
loss | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| (2,536,233 | ) | |
| (2,536,233 | ) |
Balance,
December 31, 2023 | |
| 5,481,250 | | |
$ | 547 | | |
| — | | |
$ | — | | |
$ | — | | |
$ | (14,199,669 | ) | |
$ | (14,199,122 | ) |
The
accompanying notes are an integral part of the financial statements.
PHOENIX
BIOTECH ACQUISITION CORP.
STATEMENTS
OF CASH FLOWS
| |
For the Year Ended
December
31, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
CASH
FLOWS FROM OPERATING ACTIVITIES | |
| | |
| |
Net
loss | |
$ | (2,536,233 | ) | |
$ | (667,736 | ) |
Adjustments
to reconcile net loss to net cash used in operating activities: | |
| | | |
| | |
Interest
income earned on marketable securities held in Trust Account | |
| (491,571 | ) | |
| (2,836,864 | ) |
Changes
in operating assets and liabilities: | |
| | | |
| | |
Prepaid
expenses and other assets | |
| 197,762 | | |
| 254,831 | |
Income
tax payable | |
| (575,526 | ) | |
| 599,159 | |
Accounts
payable and accrued expenses | |
| 1,881,964 | | |
| 1,638,687 | |
Franchise
tax payable | |
| - | | |
| (80,324 | ) |
Net
cash used in operating activities | |
| (1,523,604 | ) | |
| (1,092,247 | ) |
| |
| | | |
| | |
CASH
FLOWS FROM INVESTING ACTIVITIES | |
| | | |
| | |
Cash
withdrawn from Trust Account for taxes | |
| 752,300 | | |
| 144,544 | |
Investment of restricted cash into marketable securities in the Trust
Account | |
| (14,335,919 | ) | |
| (325,000 | ) |
Cash
withdrawn from Trust Account in connection with Class A common stock redemption | |
| 5,638,879 | | |
| 181,019,852 | |
Net
cash provided by investing activities | |
| (7,944,740 | ) | |
| 180,839,396 | |
| |
| | | |
| | |
CASH
FLOWS FROM FINANCING ACTIVITIES: | |
| | | |
| | |
Proceeds
from promissory note - related party | |
| 905,000 | | |
| 650,000 | |
Redemption
of Class A common stock | |
| (33,481,627 | ) | |
| (139,353,878 | ) |
Net
cash used in financing activities | |
| (32,576,627 | ) | |
| (138,703,878 | ) |
| |
| | | |
| | |
NET
CHANGE IN CASH AND RESTRICTED CASH | |
| (42,044,971 | ) | |
| 41,043,271 | |
CASH
AND RESTRICTED CASH, BEGINNING OF PERIOD | |
| 42,141,844 | | |
| 1,098,573 | |
CASH
AND RESTRICTED CASH, END OF PERIOD | |
$ | 96,873 | | |
$ | 42,141,844 | |
| |
| | | |
| | |
Supplemental
cash flow information: | |
| | | |
| | |
Cash
paid for income taxes | |
$ | 670,345 | | |
$ | — | |
| |
| | | |
| | |
Supplemental
disclosure of noncash activities: | |
| | | |
| | |
Accretion
of Class A common stock subject to possible redemption | |
$ | 606,346 | | |
$ | 2,662,553 | |
Shareholder
redemption liability | |
$ | — | | |
$ | 27,842,747 | |
Conversion
of Class B common to Class A common | |
$ | (459 | ) | |
$ | — | |
Excise
tax liability accrued for Class A common stock redemptions | |
$ | 56,389 | | |
$ | — | |
The
accompanying notes are an integral part of the financial statements.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Note
1 — Description of Organization and Business Operations and Liquidity
Phoenix
Biotech Acquisition Corp. (the “Company”) was incorporated in Delaware on June 8, 2021. The Company was formed for the purpose
of effecting a merger, capital stock exchange, asset acquisition, stock purchase, reorganization, or similar business combination with
one or more businesses (a “business combination”).
The
Company is not limited to a particular industry or geographic region for purposes of consummating a business combination. The Company
is an early stage and emerging growth company and, as such, the Company is subject to all of the risks associated with early stage and
emerging growth companies.
As
of December 31, 2023, the Company had not commenced any operations. All activity through December 31, 2023 relates to the Company’s
formation and initial public offering (“IPO”), which is described below and, since the offering, the search for a prospective
initial business combination. The Company will not generate any operating revenues until after the completion of its initial business
combination, at the earliest. The Company generates non-operating income in the form of interest income earned on investments from the
proceeds derived from the IPO and placed in the Trust Account (defined below). The registration statement for the Company’s IPO
was declared effective on October 5, 2021. On October 8, 2021, the Company consummated the IPO of 15,500,000 units (“Units”)
(with respect to the Class A common stock included in the Units being offered (the “Public Shares”)) at $10.00 per Unit generating
gross proceeds of $155,000,000, which is discussed in Note 3. The Company has selected December 31 as its fiscal year end.
Simultaneously
with the closing of the IPO, the Company consummated the sale of 845,000 units (“Private Placement Units”) (with respect
to the Class A common stock included in the Private Placement Units offered, the “Private Placement Shares”) at a price
of $10.00 per Private Placement Unit in a private placement to the Company’s sponsor, Phoenix Biotech Sponsor, LLC (the
“Sponsor”), Cantor Fitzgerald & Co. (“Cantor”) and Cohen & Company Capital Markets, a division of
J.V.B. Financial Group, LLC (“CCM”), generating gross proceeds of $8,450,000, which is described in Note 4.
Simultaneously
with the closing of the IPO, the Company consummated the sale of 2,000,000 additional Units upon receiving notice of the underwriter’s
election to partially exercise its overallotment option (“Overallotment Units”), generating additional gross proceeds of
$20,000,000 and incurring additional offering costs of $1,400,000 in underwriting fees, all of which are deferred until the completion
of the Company’s initial business combination. Simultaneously with the exercise of the overallotment, the Company consummated the
Private Placement of an additional 40,000 Private Placement Units to the Sponsor and CCM, generating gross proceeds of $400,000.
Offering
costs for the IPO and exercise of the overallotment option amounted to $12,729,318, consisting of $2,635,000 of underwriting fees, $9,150,000
of deferred underwriting fees payable (which are held in the Trust Account (defined below)) and $944,318 of other costs. As described
in Note 6, the $9,150,000 of deferred underwriting fees payable is contingent upon the consummation of a business combination by January
8, 2024, subject to the terms of the underwriting agreement.
Following
the closing of the IPO, $178,500,000 ($10.20 per Unit) from the net proceeds of the sale of the Units in the IPO, the Overallotment Units
and the Private Placement Units was placed in a trust account (“Trust Account”) and invested in U.S. government securities,
within the meaning set forth in Section 2(a)(16) of the Investment Company Act of 1940, as amended (the “Investment Company Act”),
with a maturity of 185 days or less or in money market funds meeting the conditions of the Investment Company Act, as determined by the
Company, until the earlier of: (i) the completion of a business combination and (ii) the distribution of the Trust Account, as described
below.
The
Company’s management has broad discretion with respect to the specific application of the net proceeds of the IPO and the sale
of the Private Placement Units, although substantially all of the net proceeds are intended to be applied generally toward consummating
a business combination. There is no assurance that the Company will be able to complete a business combination successfully. The Company
must complete one or more initial business combinations having an aggregate fair market value of at least 80% of the assets held in the
Trust Account (excluding the deferred underwriting commissions and taxes payable on income earned on the Trust Account) at the time of
the agreement to enter into the initial business combination. However, the Company will only complete a business combination if the post-transaction
company owns or acquires 50% or more of the outstanding voting securities of the target or otherwise acquires a controlling interest
in the target sufficient for it not to be required to register as an investment company under the Investment Company Act. There is no
assurance the Company will be able to successfully effect a business combination.
The
Company will provide the holders of the outstanding Public Shares (the “Public Stockholders”) with the opportunity to redeem
all or a portion of their Public Shares upon the completion of a business combination either (i) in connection with a stockholder meeting
called to approve the business combination or (ii) by means of a tender offer. The decision as to whether the Company will seek stockholder
approval of a business combination or conduct a tender offer will be made by the Company. The Public Stockholders will be entitled to
redeem their Public Shares for a pro rata portion of the amount then in the Trust Account (initially $10.20 per Public Share, plus any
pro rata interest then in the Trust Account, net of taxes payable). There will be no redemption rights with respect to the Company’s
warrants.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
All
of the Public Shares contain a redemption feature which allows for the redemption of such Public Shares in connection with the Company’s
liquidation, if there is a stockholder vote or tender offer in connection with the Company’s business combination and in connection
with certain amendments to the Company’s amended and restated certificate of incorporation (the “Charter”). In accordance
with the rules of the U.S. Securities and Exchange Commission (the “SEC”) and its guidance on redeemable equity instruments,
which has been codified in Accounting Standards Codification (“ASC”) 480-10-S99, redemption provisions not solely within
the control of a company require common stock subject to redemption to be classified outside of permanent equity. Given that the Public
Shares were issued with other freestanding instruments (i.e., public warrants), the initial carrying value of Class A common stock classified
as temporary equity will be the allocated proceeds determined in accordance with ASC 470-20. The Class A common stock is subject to ASC
480-10-S99. If it is probable that the equity instrument will become redeemable, the Company has the option to either (i) accrete changes
in the redemption value over the period from the date of issuance (or from the date that it becomes probable that the instrument will
become redeemable, if later) to the earliest redemption date of the instrument or (ii) recognize changes in the redemption value immediately
as they occur and adjust the carrying amount of the instrument to equal the redemption value at the end of each reporting period. The
Company has elected to recognize the changes immediately. The accretion or remeasurement will be treated as a deemed dividend (i.e.,
a reduction to retained earnings, or in the absence of retained earnings, additional paid-in capital). While redemptions cannot cause
the Company’s net tangible assets to fall below $5,000,001, the Public Shares are redeemable and are classified as such on the
balance sheet until such date that a redemption event takes place.
Redemptions
of the Company’s Public Shares may be subject to the satisfaction of conditions, including minimum cash conditions, pursuant to
an agreement relating to a business combination. If the Company seeks stockholder approval of the business combination, the Company will
proceed with a business combination if a majority of the shares voted are voted in favor of the business combination, or such other vote
as required by law or stock exchange rule. If a stockholder vote is not required by applicable law or stock exchange listing requirements
and the Company does not decide to hold a stockholder vote for business or other reasons, the Company will, pursuant to its Charter,
conduct the redemptions pursuant to the tender offer rules of the SEC and file tender offer documents with the SEC prior to completing
a business combination. If, however, stockholder approval of the transaction is required by applicable law or stock exchange listing
requirements, or the Company decides to obtain stockholder approval for business or other reasons, the Company will offer to redeem shares
in conjunction with a proxy solicitation pursuant to the proxy rules and not pursuant to the tender offer rules. If the Company seeks
stockholder approval in connection with a business combination, the Sponsor has agreed to vote its Founder Shares (as defined in Note
5), Private Placement Shares and any Public Shares purchased during or after the IPO in favor of approving a business combination. Additionally,
each Public Stockholder may elect to redeem their Public Shares without voting, and if they do vote, irrespective of whether they vote
for or against the proposed transaction.
Notwithstanding
the foregoing, the Charter provides that a Public Stockholder, together with any affiliate of such stockholder or any other person with
whom such stockholder is acting in concert or as a “group” (as defined under Section 13 of the Securities Exchange Act of
1934, as amended (the “Exchange Act”)), will be restricted from redeeming its shares with respect to more than an aggregate
of 20% or more of the Class A common stock sold in the IPO, without the prior consent of the Company.
The
Company’s Sponsor, officers and directors (the “Initial Stockholders”) have agreed not to propose an amendment to the
Charter that would affect the substance or timing of the Company’s obligation to redeem 100% of its Public Shares if the Company
does not complete a business combination within the business combination period, unless the Company provides the Public Stockholders
with the opportunity to redeem their shares of Class A common stock in conjunction with any such amendment.
On
December 16, 2022, the Company held a special meeting of its stockholders (the “First Special Meeting”). At the Special Meeting,
the Company’s stockholders approved an amendment (the “First IMTA Amendment”) to the Company’s Investment Management
Trust Agreement (the “IMTA”), dated October 5, 2021, with Continental Stock Transfer & Trust Company (“CST”),
as trustee, and an amendment to the Company’s Charter (the “First Charter Amendment”), to extend the business combination
period up to three times for three months each time (the “First Extension”).
In
connection with the First Special Meeting, the Sponsor agreed that if the First Charter Amendment and the First IMTA Amendment were approved
at the First Special Meeting, the Sponsor, or one or more of its affiliates, members or third-party designees (in such capacity, the
“Lender”), would lend to the Company up to $1,500,000 to be deposited into the Trust Account established in connection with
the IPO. Accordingly, on December 20, 2022, the Company issued an unsecured promissory note in the principal amount of $1,500,000 (the
“Promissory Note”) to the Lender, pursuant to which the Lender agreed to loan to the Company up to $1,500,000 in connection
with the extension of the date by which the Company has to consummate an initial Business Combination.
In
connection with the approval of the Extension, holders of 16,211,702 Public Shares exercised redemption rights. As a result, following
the satisfaction of such redemptions, as of December 31, 2022, the Company had 2,173,298 shares of Class A common stock outstanding,
of which (i) 1,288,298 were Public Shares, which were entitled to receive a pro rata portion of the remaining funds in the Trust Account
in connection with its initial Business Combination, a liquidation or certain other events, and (ii) 885,000 were Private Placement Shares,
which did not have redemption rights.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
On
March 31, 2023, May 8, 2023 and June 30, 2023, the Company deposited $100,000, $125,000 and $150,000 into the Trust Account in connection
with the First Extension.
On
July 7, 2023, the Company held a special meeting of its stockholders (the “Second Special Meeting”). At the Second Special
Meeting, the Company’s stockholders approved an amendment to the IMTA, as amended by the IMTA Amendment (the “Second IMTA
Amendment”), and an amendment to the Company’s Charter, as amended by the Charter Amendment (the “Second Charter Amendment”),
to extend the business combination period for up to six times for one month each time (the “Second Extension”).
On July 7, 2023, July 28,
2023, September 1, 2023, October 4, 2023, November 2, 2023 and November 30, 2023, the Company deposited $37,052, $8,846, $22,949, $22,949,
$22,949 and $22,949 into the Trust Account in connection with the Second Extension.
As
a result of the deposits described above, such payments and accrual of interest, the balance in the Trust Account as of December 31,
2023 is approximately $8.4 million.
If
the Company is unable to complete a business combination by January 8, 2024 (as extended) (the “business combination period”),
the Company will (i) cease all operations except for the purpose of winding up, (ii) as promptly as reasonably possible but not more
than ten business days thereafter, redeem the Public Shares, at a per-share price, payable in cash, equal to the aggregate amount then
on deposit in the Trust Account including interest earned on the funds held in the Trust Account and not previously released to us to
pay the Company’s franchise and income taxes (less up to $100,000 of interest to pay dissolution expenses), divided by the number
of then outstanding Public Shares, which redemption will completely extinguish Public Stockholders’ rights as stockholders (including
the right to receive further liquidating distributions, if any), subject to applicable law, and (iii) as promptly as reasonably possible
following such redemption, subject to the approval of the Company’s remaining stockholders and the Company’s board of directors,
dissolve and liquidate, subject in each case to the Company’s obligations under Delaware law to provide for claims of creditors
and the requirements of other applicable law.
The
Initial Stockholders have agreed to waive their liquidation rights with respect to the Founder Shares and Private Placement Shares if
the Company fails to complete a business combination within the business combination period. However, if the Initial Stockholders should
acquire Public Shares in or after the IPO, they will be entitled to liquidating distributions from the Trust Account with respect to
such Public Shares if the Company fails to complete a business combination within the business combination period. The underwriter has
agreed to waive its rights to the deferred underwriting commission (see Note 6) held in the Trust Account in the event the Company does
not complete a business combination within the business combination period, and, in such event, such amounts will be included with the
other funds held in the Trust Account that will be available to fund the redemption of the Public Shares. In the event of such distribution,
it is possible that the per share value of the residual assets remaining available for distribution (including Trust Account assets)
will be only $10.20 per share held in the Trust Account. In order to protect the amounts held in the Trust Account, the Sponsor has agreed
to be liable to the Company if and to the extent any claims by a vendor for services rendered or products sold to the Company, or a prospective
target business with which the Company has discussed entering into a transaction agreement, reduce the amount of funds in the Trust Account.
This liability will not apply with respect to any claims by a third party who executed a waiver of any right, title, interest or claim
of any kind in or to any monies held in the Trust Account or to any claims under the Company’s indemnity of the underwriter of
the IPO against certain liabilities, including liabilities under the Securities Act of 1933, as amended (the “Securities Act”).
Moreover, in the event that an executed waiver is deemed to be unenforceable against a third party, the Sponsor will not be responsible
to the extent of any liability for such third-party claims.
The
Company will seek to reduce the possibility that the Sponsor will have to indemnify the Trust Account due to claims of creditors by endeavoring
to have all vendors, service providers (except the Company’s independent registered public accounting firm), prospective target
businesses or other entities with which the Company does business, execute agreements waiving any right, title, interest or claim of
any kind in or to monies held in the Trust Account.
Business
Combination Agreement with CERo Therapeutics, Inc. (“CERo”)
On June 4, 2023, the Company entered into a business combination
agreement and plan of reorganization (the “Business Combination Agreement”), by and among the Company, PBCE Merger Sub, Inc.,
a Delaware corporation (“Merger Sub”), and CERo. Immediately after the merger, the Company changed its name from Phoenix Biotech
Acquisition Corporation to CERo Therapeutics Holdings, Inc.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
At the effective time (the “Effective Time”) of the of
the merger between Merger Sub and CERo (the “Business Combination”), (i) each outstanding share of CERo common stock,
par value $0.0001 per share (the “CERo common stock”), will be cancelled and converted into (a) the right to receive
a number of shares of Class A common stock, par value $0.0001 per share (“Class A common stock”), equal to $50,000,000, minus the
Aggregate Liquidation Preference (as defined in the Business Combination Agreement), divided by the Fully Diluted Company
Capitalization (as defined in the Business Combination Agreement), divided by $10.00 (the “Exchange Ratio”)
and (b) the right to receive a portion of up to 2,200,000 additional shares of Class A common stock if certain trading price
hurdles are achieved or a Change of Control (as defined in the Business Combination Agreement) occurs within four years after the Closing
(“Earnout Shares”); (ii) each outstanding option to purchase CERo common stock (each, a “CERo option”) will
be converted into an option to purchase a number of shares of Class A common stock, equal to (A) the number of shares of CERo
common stock subject to such option immediately prior to the Effective Time, multiplied by (B) the Exchange Ratio,
at an exercise price per share equal to the current exercise price per share for such option divided by the Exchange Ratio; in each case,
rounded down to the nearest whole share, and rounded up to the nearest whole cent in the case of the exercise price of the CERo options;
(iii) each outstanding share of CERo preferred stock, par value $0.0001 per share (the “CERo preferred stock”), will
be converted into a number of shares of Class A common stock, equal to the number of shares of Class A common stock obtained
by dividing the liquidation preference thereof by $10.00 and the contingent right to receive such holder’s Earn-Out Pro
Rata Portion (as defined in the Business Combination Agreement), and (iv) each warrant to purchase CERo preferred stock (each, a
“CERo warrant”) outstanding as of immediately prior to the Effective Time will be converted into a warrant to acquire a number
of shares of Class A common stock equal to the number of shares of CERo preferred stock subject to the corresponding warrant immediately
prior to the Effective Time, multiplied by the Aggregate Liquidation Preference of such underlying shares of CERo preferred
stock, and divided by $10.00, with the exercise price per share for such warrant equal to (A) the current aggregate
exercise price of such warrant (the current exercise price per share of CERo preferred stock applicable to the corresponding warrant immediately
prior to the Effective Time, multiplied by the number of shares of CERo preferred stock issuable upon exercise thereof), divided by
(B) the number of shares of Class A common stock issuable upon exercise thereof. Subject to certain exceptions, such terms and
conditions applicable to a CERo Therapeutics Holdings, Inc. (“New CERo”) warrant will be the same terms and conditions as
were applicable to a CERo warrant immediately prior to the Effective Time. The Company will issue an aggregate of approximately 5.0 million
shares of Class A common stock to the holders of CERo common stock and CERo preferred stock as consideration in the Business Combination.
NASDAQ
Notice
On
April 3, 2023, the Company received a letter (the “Letter”) from the staff at The Nasdaq Global Market (“Nasdaq”)
notifying the Company that, for the 30 consecutive trading days prior to the date of the Letter, the Company’s common stock had
traded at a value below the minimum $50,000,000 “Market Value of Listed Securities” (“MVLS”) requirement set
forth in Nasdaq Listing Rule 5450(b)(2)(A), which is required for continued listing of the Company’s common stock on Nasdaq. The
Letter is only a notification of deficiency, not of imminent delisting, and has no current effect on the listing or trading of the Company’s
securities on Nasdaq.
In
order to bring the Company into compliance with the MVLS requirement, on July 3, 2023, the Sponsor elected to effect the Conversion.
As of the date hereof, there are 6,246,207 shares of Class A common stock and no shares of Class B common stock issued and outstanding
and entitled to vote.
On
September 7, 2023, the Company received a written notice (the “Notice”) from the Nasdaq Listing Qualifications Department
of Nasdaq indicating that the Company was not in compliance with Listing Rule 5450(a)(2), which requires the Company to have at least
400 public holders for continued listing on the Nasdaq Global Market (the “Minimum Public Holders Rule”). The Notice is only
a notification of deficiency, not of imminent delisting, and has no current effect on the listing or trading of the Company’s securities
on Nasdaq Global Market. The Notice states that the Company has 45 calendar days to submit a plan to regain compliance with the Minimum
Public Holders Rule. The Company has submitted a plan to regain compliance with the Minimum Public Holders Rule. If Nasdaq accepts the
Company’s plan, Nasdaq may grant the Company an extension of up to 180 calendar days from the date of the Notice to evidence compliance
with the Minimum Public Holders Rule. If Nasdaq does not accept the Company’s plan, the Company will have the opportunity to appeal
the decision in front of a Nasdaq Hearings Panel.
The
MVLS deficiency was cured by the conversion of the Class B common stock into Class A common stock because the Class A common stock held
by Sponsor count towards satisfying such requirement. The Company submitted a “plan of compliance” to NASDAQ indicating that
the Company was aiming to be able to cure the deficiency upon closing of the Business Combination. Nasdaq has not responded.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Inflation
Reduction Act of 2022 (the “IR Act”)
On
August 16, 2022, the Inflation Reduction Act of 2022 (the “IR Act”) was signed into federal law. The IR Act provides for,
among other things, a new U.S. federal 1% excise tax on certain repurchases of stock by publicly traded U.S. domestic corporations and
certain U.S. domestic subsidiaries of publicly traded foreign corporations occurring on or after January 1, 2023. The excise tax is imposed
on the repurchasing corporation itself, not its stockholders from which shares are repurchased. The amount of the excise tax is generally
1% of the fair market value of the shares repurchased at the time of the repurchase. However, for purposes of calculating the excise
tax, repurchasing corporations are permitted to net the fair market value of certain new stock issuances against the fair market value
of stock repurchases during the same taxable year. In addition, certain exceptions apply to the excise tax. The U.S. Department of the
Treasury (the “Treasury”) has been given authority to provide regulations and other guidance to carry out and prevent the
abuse or avoidance of the excise tax.
Any
redemption or other repurchase that occurs after December 31, 2022, in connection with a business combination, extension vote or otherwise,
may be subject to the excise tax. Whether and to what extent the Company would be subject to the excise tax in connection with a business
combination, extension vote or otherwise would depend on a number of factors, including (i) the fair market value of the redemptions
and repurchases in connection with the business combination, extension or otherwise, (ii) the structure of a business combination, (iii)
the nature and amount of any “PIPE” or other equity issuances in connection with a business combination (or otherwise issued
not in connection with a business combination but issued within the same taxable year of a business combination) and (iv) the content
of regulations and other guidance from the Treasury. In addition, because the excise tax would be payable by the Company and not by the
redeeming holder, the mechanics of any required payment of the excise tax have not been determined. The foregoing could cause a reduction
in the cash available on hand to complete a business combination and in the Company’s ability to complete a business combination.
On
July 17, 2023, the Company redeemed 523,341 shares of Class A common stock tendered for redemption by the Public Stockholders for a total
redemption amount of $5,638,879 in connection with the implementation of the Extension. The Company evaluated the classification and
accounting of the stock redemption under ASC 450, “Contingencies” to determine whether the Company should currently recognize
an excise tax obligation associated therewith. ASC 450 states that when a loss contingency exists the likelihood that the future event(s)
will confirm the loss or impairment of an asset, or the incurrence of a liability can range from probable to remote. Contingent liability
must be reviewed at each reporting period to determine appropriate treatment. The Company evaluated whether a United States excise tax
obligation should be recognized currently related to the stock redemption and concluded that this obligation should be recognized. As
of December 31, 2023, the Company recorded $56,389 of excise tax liability calculated as 1% of shares redeemed on July 17, 2023. Any
reduction to this liability resulting from either a subsequent stock issuance or an event giving rise to an exception that occurs within
this tax year, will be recognized in the period (including an interim period) that such stock issuance or event giving rise to an exception
occurs.
Liquidity
and Going Concern
As
of December 31, 2023, the Company had $96,873 in its operating bank accounts, $8,436,311 in marketable securities held in the Trust Account
to be used for a business combination or to repurchase or redeem its Public Shares in connection therewith and a working capital deficit
of $5,049,122.
On
May 9, 2023, the Company received a notice from the IRS stating an additional $182,308 of federal income taxes were due by May 22, 2023.
The Company made this payment on June 23, 2023.
The accompanying financial
statements have been prepared assuming that the Company will continue as a going concern, which contemplates the realization of assets
and satisfaction of liabilities in the normal course of business. The Company’s ability to continue as a going concern is dependent
on its ability to raise additional capital to fund its research and development (“R&D”) activities and meet its obligations
on a timely basis. Since inception, the Company has incurred net losses and operating cash flow deficits, resulting in an accumulated
deficit of $14.2 million as of December 31, 2023. On February 14, 2024, the Company acquired the assets of CERo Therapeutics, Inc.,
closed a private placement with gross proceeds of $9.98 million, and assumed the R&D operations of CERo Therapeutics. Additional funds
are necessary to maintain current operations and to continue R&D activities. However, there can be no assurance that sufficient funding
will be available to allow the Company to successfully continue its R&D activities and planned regulatory filings with the Food and
Drug Administration (“FDA”). If the Company is unable to obtain necessary funds, significant reductions in spending and the
delay or cancellation of planned activities may be necessary. These actions would have a material adverse effect on the Company’s
business, results of operations, and prospects. These conditions raise substantial doubt about the Company’s ability to continue
as a going concern within one year from the date these financial statements are issued. The accompanying financial statements do not include
any adjustments relating to the recoverability and classification of recorded asset amounts or the amounts and classification of liabilities
that might result from the outcome of this uncertainty.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Note
2 — Summary of Significant Accounting Policies
Basis
of Presentation
The
accompanying financial statements are presented in accordance with accounting principles generally accepted in the United States of America
(“GAAP”) and pursuant to the rules and regulations of the SEC.
Reclassifications
Certain
prior year amounts have been reclassified due to an immaterial correction of an error and for consistency with the current period presentation.
These reclassifications had no effect on the reported results of operations. An adjustment for $244,777 has been made to Class A
common stock subject to possible redemption and Accumulated deficit as of December 31, 2022 to correct the total amount redeemable
to stockholders.
In the Form 10-Q for three
months ended March 31, 2023, the Company discovered an error in the Statement of Cash Flows for the presentation of restricted cash. The
error was not corrected and persisted in the statements of cash flows in the quarterly reports on 10-Q for the three months ended June
30, 2023 and September 30, 2023. These errors had no impact on the balance sheets or the statements of operations in those periods. This
error is corrected in the statement of cash flows in the Company’s December 31, 2023 audited financial statements.
Emerging
Growth Company
The
Company is an “emerging growth company,” as defined in Section 2(a) of the Securities Act, as modified by the Jumpstart Our
Business Startups Act of 2012 (the “JOBS Act”), and it may take advantage of certain exemptions from various reporting requirements
that are applicable to other public companies that are not emerging growth companies including, but not limited to, not being required
to comply with the independent registered public accounting firm attestation requirements of Section 404 of the Sarbanes-Oxley Act, reduced
disclosure obligations regarding executive compensation in its periodic reports and proxy statements, and exemptions from the requirements
of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously
approved.
Further,
Section 102(b)(1) of the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting
standards until private companies (that is, those that have not had a Securities Act registration statement declared effective or do
not have a class of securities registered under the Exchange Act) are required to comply with the new or revised financial accounting
standards. The JOBS Act provides that a company can elect to opt out of the extended transition period and comply with the requirements
that apply to non-emerging growth companies but any such election to opt out is irrevocable. The Company has elected not to opt out of
such extended transition period which means that when a standard is issued or revised and it has different application dates for public
or private companies, the Company, as an emerging growth company, can adopt the new or revised standard at the time private companies
adopt the new or revised standard. This may make comparison of the Company’s financial statements with another public company which
is neither an emerging growth company nor an emerging growth company which has opted out of using the extended transition period difficult
or impossible because of the potential differences in accounting standards used.
Use
of Estimates
The
preparation of financial statements in conformity with U.S. GAAP requires the Company’s management to make estimates and assumptions
that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the reporting period.
Making
estimates requires management to exercise significant judgment. Such estimates may be subject to change as more current information becomes
available and accordingly the actual results could differ significantly from those estimates. It is at least reasonably possible that
the estimate of the effect of a condition, situation or set of circumstances that existed at the date of the financial statements, which
management considered in formulating its estimate, could change in the near term due to one or more future confirming events. Actual
results could differ from those estimates.
Cash
and Cash Equivalents
The
Company considers all short-term investments with an original maturity of three months or less when purchased to be cash equivalents.
The Company did not have any cash equivalents as of December 31, 2023 and 2022.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Restricted
Cash
The
Company considers all cash to be held for a specific purpose restricted cash. As of December 31, 2023 and 2022, the Company had $0 and
$41,665,974 in restricted cash, respectively. The restricted cash as of December 31, 2022 was intended to satisfy stockholder redemption
payments. The cash and restricted cash balances included in the balance sheets as of December 31, 2023 and 2022, are comprised of
the following:
| |
December 31, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Cash | |
$ | 96,873 | | |
$ | 475,870 | |
Restricted cash | |
| — | | |
| 41,665,974 | |
Total cash and restricted cash | |
$ | 96,873 | | |
$ | 42,141,844 | |
Money
Market Funds Held in Trust Account
At
December 31, 2023, the assets held in Trust Account were held in money market funds that invested in U.S. Treasury securities. At December 31,
2022, substantially all of the assets held in the Trust Account were held as cash. The Company’s investments held in the Trust
Account are classified as trading securities. Trading securities are presented on the balance sheets at fair value at the end of each
reporting period. Gains and losses resulting from the change in fair value of investments held in the Trust Account and interest
earned on marketable securities are included in the accompanying statements of operations. The estimated fair values of investments held
in the Trust Account are determined using available market information.
Shareholder
Redemption Liability
On
December 20, 2022, in connection with the Company’s special meeting held to consider the First Charter Amendment, the Company’s
stockholders redeemed 16,211,702 shares of Class A common stock subject to possible redemption at $10.20 per share redemption
value, plus a pro rata share of interest earned. Of the total amount redeemed, payments for 2,581,004 shares of Class A
common stock totaling $26,481,101 plus a true-up payment of $1,361,646 for a total liability of $27,842,747 were subsequently paid to
redeeming stockholders on January 3, 2023. Therefore, a portion of the total redemption payment has been classified as a stockholder
redemption liability in the accompanying balance sheet as of December 31, 2022.
Offering
Costs Associated with the IPO
Offering
costs, including additional underwriting fees associated with the underwriter’s partial exercise of the over-allotment option,
consist principally of legal, accounting, underwriting fees and other costs directly related to the IPO. Offering costs, including those
attributable to the underwriter’s partial exercise of the over-allotment option, amounted to $12,729,318. This amount was charged
to stockholders’ deficit upon the completion of the IPO.
Concentration
of Credit Risk
Financial
instruments that potentially subject the Company to concentrations of credit risk consist of cash accounts in a financial institution,
which, at times, may exceed the Federal Deposit Insurance Corporation coverage limit of $250,000. At December 31, 2023 and 2022, the
Company has not experienced losses on these accounts and management believes the Company is not exposed to significant risks on such
accounts.
Fair
Value of Financial Instruments
The
fair value of the Company’s financial assets and liabilities reflects management’s estimate of amounts that the Company would
have received in connection with the sale of the assets or paid in connection with the transfer of the liabilities in an orderly transaction
between market participants at the measurement date. In connection with measuring the fair value of its assets and liabilities, the Company
seeks to maximize the use of observable inputs (market data obtained from independent sources) and to minimize the use of unobservable
inputs (internal assumptions about how market participants would price assets and liabilities). The following fair value hierarchy is
used to classify assets and liabilities based on the observable inputs and unobservable inputs used in order to value the assets and
liabilities:
Level 1:
Quoted prices in active markets for identical assets or liabilities. An active market for an asset or liability is a market in which
transactions for the asset or liability occur with sufficient frequency and volume to provide pricing information on an ongoing basis.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Level 2:
Observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar
assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.
Level 3:
Unobservable inputs based on the Company’s assessment of the assumptions that market participants would use in pricing the asset
or liability.
Income
Taxes
The
Company complies with the accounting and reporting requirements of ASC 740, “Income Taxes” (“ASC 740”), which
requires an asset and liability approach to financial accounting and reporting for income taxes. Deferred income tax assets and liabilities
are computed for differences between the financial statement and tax bases of assets and liabilities that will result in future taxable
or deductible amounts, based on enacted tax laws and rates applicable to the periods in which the differences are expected to affect
taxable income. Valuation allowances are established, when necessary, to reduce deferred tax assets to the amount expected to be realized.
ASC
740 prescribes a recognition threshold and a measurement attribute for the financial statement recognition and measurement of tax positions
taken or expected to be taken in a tax return. For those benefits to be recognized, a tax position must be more likely than not to be
sustained upon examination by taxing authorities. There were no unrecognized tax benefits as of December 31, 2023 and 2022. The Company
recognizes accrued interest and penalties related to unrecognized tax benefits as income tax expense. No amounts were accrued for the
payment of interest and penalties at December 31, 2023 and 2022. The Company is currently not aware of any issues under review that could
result in significant payments, accruals, or material deviation from its position. The Company is subject to income tax examinations
by major taxing authorities since inception.
Deferred
tax liabilities and assets are determined based on the difference between the financial statement and tax basis of assets and liabilities,
using enacted tax rates in effect for the year in which the differences are expected to reverse. Current income taxes are based on the
year’s income taxable for federal and state income tax reporting purposes. Total tax provision may differ from the statutory tax
rates applied to income before provision for income taxes due principally to expenses charged which are not tax deductible.
The
total provision benefit for income taxes is comprised of the following:
| |
December 31,
2023 | | |
December 31,
2022 | |
Current expense | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
Deferred tax benefit | |
| — | | |
| — | |
Change
in valuation allowance | |
| — | | |
| — | |
Total
income tax (expense) benefit | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
The
net deferred tax assets in the accompanying balance sheets included the following components:
| |
December 31,
2023 | | |
December 31,
2022 | |
Deferred tax assets | |
$ | 607,516 | | |
$ | 596,692 | |
Deferred tax liabilities | |
| — | | |
| — | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Net
deferred tax assets | |
$ | — | | |
$ | — | |
The
deferred tax assets as of December 31, 2023 and 2022 were comprised of the tax effect of cumulative temporary differences as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
General and administration
expenses before business combination | |
$ | 607,516 | | |
$ | 596,692 | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Total | |
$ | — | | |
$ | — | |
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
In
assessing the realization of deferred tax assets, management considers whether it is more likely than not that some portion or all of
the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future
taxable income during the periods in which temporary differences representing net future deductible amounts become deductible. Management
considers the scheduled reversal of deferred tax assets, projected future taxable income and tax planning strategies in making this assessment.
For the year ended December 31, 2023 and 2022, the valuation allowance was $607,516 and $596,692, respectively.
A
reconciliation of the statutory federal income tax provision (benefit) to the Company’s effective tax rate is as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
Statutory
federal income tax rate | |
| 21.0 | % | |
| 21.0 | % |
State
taxes, net of federal tax benefit | |
| 0.0 | % | |
| 0.0 | % |
Valuation
allowance | |
| (17.33 | )% | |
| 852.7 | % |
Income
tax provision (benefit) | |
| 3.67 | % | |
| 873.7 | % |
Class A
Common Stock Subject to Possible Redemption
The
Company accounts for its Class A common stock subject to possible redemption in accordance with the guidance in ASC 480. Shares
of Class A common stock subject to mandatory redemption (if any) are classified as a liability instrument and are measured at fair
value. Conditionally redeemable Class A common stock (including Class A common stock that features redemption rights that are within
the control of the holder or subject to redemption upon the occurrence of uncertain events not solely within the Company’s control)
is classified as temporary equity. At all other times, Class A common stock is classified as stockholders’ equity. The Company’s
Class A common stock features certain redemption rights that are considered to be outside of the Company’s control and subject
to occurrence of uncertain future events. Accordingly, at December 31, 2023 and 2022, 764,957 and 1,288,298 shares of Class A common
stock subject to possible redemption are presented as temporary equity, outside of the stockholders’ deficit section of the Company’s
balance sheets.
The
Company recognizes changes in redemption value immediately as they occur and adjusts the carrying value of redeemable Class A common
stock to equal the redemption value at the end of each reporting period. Increases or decreases in the carrying amount of redeemable
common stock are affected by charges against additional paid in capital and accumulated deficit.
At
December 31, 2023 and 2022, the Class A common stock subject to possible redemption reflected in the balance sheets is reconciled
in the following table:
Class A common stock subject to possible redemption, December 31, 2021 | |
$ | 178,500,000 | |
Plus: Accretion of carrying value to redemption value | |
| 2,662,553 | |
Less: redemption of shares | |
| (167,693,708 | ) |
Class A common stock subject to possible redemption, December 31, 2022 | |
$ | 13,468,845 | |
Less: Redemption | |
| (5,638,880 | ) |
Plus: Accretion of carrying value to redemption value | |
| 606,346 | |
Class A common stock subject to possible redemption, December 31, 2023 | |
$ | 8,436,311 | |
Net
Loss per Common Stock
The
Company has two classes of shares, which are referred to as Class A common stock and Class B common stock (the “Class
B common stock” or the “Founder Shares”). Earnings and losses are shared pro rata between the two classes of shares.
Public Warrants (see Note 3) and Private Placement Warrants (see Note 4) to purchase an aggregate of 9,192,500 shares of Class A
common stock at $11.50 per share were issued on October 29, 2021. At December 31, 2023 and December 31, 2022, no Public
Warrants or Private Placement Warrants have been exercised. The 9,192,500 shares of Class A common stock underlying outstanding
Public Warrants and Private Placement Warrants were excluded from diluted net income per share for the year ended December
31, 2023 and 2022 because they are contingently exercisable, and the contingencies have not yet been met. As a result, diluted net income
per common stock is the same as basic net income per common stock for the period. The tables below present a reconciliation of the numerator
and denominator used to compute basic and diluted net income per share for each class of stock.
| |
For
the Year Ended December 31, | |
| |
2023 | | |
2022 | |
| |
Class A
common stock | | |
Class B
Common stock | | |
Class A
common stock | | |
Class B
Common stock | |
Basic and diluted net income per share: | |
| | |
| | |
| | |
| |
Numerator: | |
| | |
| | |
| | |
| |
Allocation
of net income | |
$ | (1,641,020 | ) | |
$ | (895,213 | ) | |
$ | (531,288 | ) | |
$ | (136,448 | ) |
Denominator: | |
| | | |
| | | |
| | | |
| | |
Weighted
average shares outstanding | |
| 4,224,247 | | |
| 2,304,421 | | |
| 17,896,428 | | |
| 4,596,250 | |
Basic and diluted net income per share | |
$ | (0.39 | ) | |
$ | (0.39 | ) | |
$ | (0.03 | ) | |
$ | (0.03 | ) |
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Accounting
for Warrants
The
Company accounts for warrants as either equity-classified or liability-classified instruments based on an assessment of the instruments’
specific terms and applicable authoritative guidance in ASC 480 and ASC 815, Derivatives and Hedging. The assessment considers
whether the instruments are free standing financial instruments pursuant to ASC 480, meet the definition of a liability pursuant to ASC
480, and whether the instruments meet all of the requirements for equity classification under ASC 815, including whether the instruments
are indexed to the Company’s own common stock and whether the instrument holders could potentially require “net cash settlement”
in a circumstance outside of the Company’s control, among other conditions for equity classification. This assessment, which requires
the use of professional judgment, was conducted at the time of warrant issuance and as of each subsequent period end date while the instruments
are outstanding. Management has concluded that the Public Warrants and Private Placement Warrants issued pursuant to the warrant agreement
qualify for equity accounting treatment.
Recent
Accounting Pronouncements
In
December 2023, the FASB issued ASU 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures (ASU 2023-09), which requires
disclosure of incremental income tax information within the rate reconciliation and expanded disclosures of income taxes paid, among
other disclosure requirements. ASU 2023-09 is effective for fiscal years beginning after December 15, 2024. Early adoption is permitted.
The Company’s management does not believe the adoption of ASU 2023-09 will have a material impact on its consolidated financial statements
and disclosures.
Management
does not believe that any other recently issued, but not yet effective, accounting standards if currently adopted would have a material
effect on the accompanying unaudited condensed financial statements.
Note
3 — Initial Public Offering and Over-Allotment
Pursuant
to the IPO, the Company sold 17,500,000 units (including 2,000,000 units as part of the underwriter’s partial exercise of the over-allotment
option) at a price of $10.00 per Unit. Each Unit consists of one Public Share, and a Public Warrant. Each Public Warrant entitles the
holder to purchase one share of Class A common stock at a price of $11.50 per share, subject to adjustment (see Note 7).
Note
4 — Private Placement Warrants
On
October 8, 2021, simultaneously with the consummation of the IPO, the Company consummated the issuance and sale (“Private
Placement”) of the Private Placement Units in a private placement transaction at a price of $10.00 per Private Placement Unit,
generating gross proceeds of $8,850,000. The Private Placement Units were purchased by Cantor (155,000 Units), CCM (30,004 Units) and
the Sponsor (699,996 Units). Each whole Private Placement Unit consists of one Private Placement Share and one-half of a redeemable
warrant (“Private Placement Warrant”). Each whole Private Placement Warrant will be exercisable to purchase one share
of Class A common stock at a price of $11.50 per share, subject to adjustment. A portion of the proceeds from the Private Placement
Units was added to the proceeds from the IPO to be held in the Trust Account. If the Company does not complete a business combination
within the Combination Period, the proceeds from the sale of the Private Placement Units will be used to fund the redemption of the Public
Shares (subject to the requirements of applicable law), and the Private Placement Units and all underlying securities will be worthless.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Note
5 — Related Party Transactions
Founder
Shares
On
September 18, 2021, the Sponsor provided funds to pay for certain costs totaling $25,000 on behalf of the Company as consideration
for 4,598,750 Founder Shares. Later in September 2021, the Company effected a 0.017 for 1 stock dividend for each Founder Share
outstanding, and, as a result, the Sponsor held 4,679,125 Founder Shares following the stock dividend. As a result, the Company’s
shares have been retroactively adjusted for this stock dividend; however, due to the shares being closely held the corresponding earnings
have not been capitalized from retained earnings. The Sponsor agreed to forfeit up to 592,875 Founder Shares to the extent that the 45-day
over-allotment option was not exercised in full by the underwriter. Since the underwriter exercised the over-allotment option only in
part, the Sponsor forfeited 82,875 Founder Shares.
The
Sponsor has agreed, subject to limited exceptions, not to transfer, assign or sell any of the Founder Shares until the earliest of: (a) one
year after the completion of a business combination and (b) subsequent to a business combination, (x) if the closing price
of the shares of Class A common stock equals or exceeds $12.00 per share (as adjusted) for any 20 trading days within any 30-trading day
period commencing at least 150 days after a business combination, or (y) the date on which the Company completes a liquidation,
merger, share exchange or other similar transaction that results in all of the Public Stockholders having the right to exchange their
shares of Class A common stock for cash, securities or other property.
On
July 3, 2023, the Sponsor delivered a notice of conversion of an aggregate of 4,596,250 Founder Shares into an equal number of shares
of Class A common stock. Such Founder Shares were subsequently converted into Class B common stock.
Related
Party Loans
On
June 18, 2021, the Sponsor agreed to loan the Company an aggregate of up to $300,000 to cover expenses related to the IPO pursuant
to a promissory note which was amended on September 10, 2021 (as amended, the “Note”). This loan is non-interest-bearing.
There was no balance on the Note as of December 31, 2023 and 2022.
In
addition, in order to finance transaction costs in connection with a business combination, the Sponsor or an affiliate of the Sponsor,
or certain of the Company’s officers and directors may, but are not obligated to, loan the Company funds as may be required (“Working
Capital Loans”). If the Company completes a business combination, the Company would repay the Working Capital Loans out of the
proceeds of the Trust Account released to the Company. Otherwise, the Working Capital Loans would be repaid only out of funds held outside
the Trust Account. In the event that a business combination does not close, the Company may use a portion of proceeds held outside the
Trust Account to repay the Working Capital Loans but no proceeds held in the Trust Account would be used to repay the Working Capital
Loans. The Working Capital Loans will either be repaid upon consummation of a business combination, without interest, or, at the lender’s
discretion, up to $1.5 million of such Working Capital Loans may be convertible into units of the post business combination entity
at a price of $10.00 per unit. The units would be identical to the Private Placement Units. On December 13, 2022, the Company entered
into a promissory note with the Sponsor. In order to fund ongoing operations, the Sponsor will loan up to $1,500,000 to the Company. The
Promissory Note does not bear interest and matures upon the earlier of (a) the closing of an initial business combination and (b) the
Company’s liquidation. In the event that the Company does not consummate an initial business combination, the Promissory Note will
be repaid only from amounts remaining outside of the Trust Account, if any. On December 8, 2023, the Company and the Lender amended the
Promissory Note to increase the aggregate principal amount of the Promissory Note from $1,500,000 to $1,600,000. All other material terms
of the Promissory Note remain in full force and effect. On May 8, 2023, June 9, 2023, September 12, 2023 and December 18,
2023, the sponsor loaned the company $250,000, $275,000, $220,000 and $160,000 under the Promissory Note in connection with extensions
of the Company’s liquidation date, respectively. As of December 31, 2023 and 2022, there was $1,555,000 and $650,000 in borrowings
under the Working Capital Loans, respectively.
Consulting
Services
The
Company entered into an agreement, commencing on the date of its listing on Nasdaq, to pay the spouse of the Company’s Chief Executive
Officer a monthly consulting fee of $15,000 for assisting the Company in identifying and evaluating potential acquisition targets. Upon
completion of the Company’s initial business combination or the Company’s liquidation, the Company’s will cease paying
these monthly fees. The payments ended on December 31, 2022 in connection with the approval of the Charter Amendment. For the year ended
December 31, 2023, $0 has been incurred under this agreement. For the year ended December 31, 2022, $180,000 has been incurred under
this agreement, respectively.
Advisory
Services
The
Company engaged CCM, an affiliate of the Company, the Sponsor and/or certain of its directors and officers, to provide consulting and
advisory services in connection with the IPO, for which it was entitled to a fee in an amount equal to $465,000, which was paid to CCM
upon the closing of the IPO, and $1,162,500, which will be paid to CCM upon the closing of the Company’s initial business combination.
Affiliates of CCM have and manage investment vehicles with a passive investment in the Sponsor.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Support
Services
The
Company entered into an agreement, commencing on the date of its listing on Nasdaq through the earlier of the consummation of a business
combination and the Company’s liquidation, to pay an affiliate of the Sponsor a monthly fee of $20,000 for office space, secretarial
and administrative services. Payments under the agreement were suspended on December 31, 2022 and reinstated on March 31, 2023. For the
year ended December 31, 2023, $200,000 has been incurred under this agreement. For the year ended December 31, 2022, $240,000 has been
incurred under this agreement, respectively. As of December 31, 2023, there was a $75,000 outstanding balance owed to the Sponsor.
Note
6 — Commitments and Contingencies
Registration
Rights
Pursuant
to a registration rights agreement entered into on October 5, 2021, the holders of the Founder Shares, Private Placement Warrants
and warrants that may be issued upon conversion of Working Capital Loans (and any Class A common stock issuable upon the exercise
of the Private Placement Warrants and warrants that may be issued upon conversion of Working Capital Loans and upon conversion of the
Founder Shares) are entitled to registration rights, requiring the Company to register such securities and any other securities of the
Company acquired by them prior to the consummation of a business combination for resale. The holders of these securities are entitled
to make up to three demands, excluding short form demands, that the Company register such securities. In addition, the holders have certain
“piggy-back” registration rights with respect to registration statements filed subsequent to the completion of a business
combination. The registration rights agreement does not contain liquidated damages or other cash settlement provisions resulting from
delays in registering the securities. The Company will bear the expenses incurred in connection with the filing of any such registration
statements.
Underwriting
Agreement
The
Company granted the underwriter a 45-day option from the date of the final prospectus relating to the IPO to purchase up to
2,325,000 additional Units to cover over-allotments, if any, at the IPO price less the underwriting discounts and commissions. On October 8,
2021, the underwriter partially exercised its over-allotment option and purchased 2,000,000 units at $10.00 per unit.
The
underwriter was paid a cash underwriting discount of $0.20 per unit, or $3,100,000 in the aggregate at the closing of the IPO, of which
$465,000 was reimbursed to the Company to pay for additional advisors. The underwriter agreed to defer any additional fees related to
the exercise of the over-allotment option until the Company completes a business combination. As such, $400,000 of additional underwriting
fees related to the over-allotment have been deferred. In addition, the underwriter is entitled to deferred underwriting commissions
of $0.50 per unit, or $8,750,000 ($9,150,000 in the aggregate when including the $400,000 noted above) from the closing of the IPO. The
deferred fee will become payable to the underwriter from the amounts held in the Trust Account solely in the event that the Company completes
a business combination, subject to the terms of the underwriting agreement.
Business
Combination Agreement
On
June 4, 2023, the Company entered into the Business Combination Agreement.
At
the Effective Time, (i) each outstanding share of CERo common stock will be cancelled and converted into (a) the right to receive
a number of shares of Class A common stock, equal to $50,000,000, minus the Aggregate Liquidation Preference, divided by
the Fully Diluted Company Capitalization, divided by the Exchange Ratio and (b) the right to receive Earnout Shares;
(ii) each outstanding CERo option will be converted into an option to purchase a number of shares of Class A common stock,
equal to (A) the number of shares of CERo common stock subject to such option immediately prior to the Effective Time, multiplied by
(B) the Exchange Ratio, at an exercise price per share equal to the current exercise price per share for such option divided by
the Exchange Ratio; in each case, rounded down to the nearest whole share, and rounded up to the nearest whole cent in the case of the
exercise price of the CERo options; (iii) each outstanding share of CERo preferred stock, will be converted into a number of shares
of Class A common stock, equal to the number of shares of Class A common stock obtained by dividing the liquidation
preference thereof by $10.00 and the contingent right to receive such holder’s Earn-Out Pro Rata Portion, and (iv) each
CERo warrant outstanding as of immediately prior to the Effective Time will be converted into a warrant to acquire a number of shares
of Class A common stock equal to the number of shares of CERo preferred stock subject to the corresponding warrant immediately prior
to the Effective Time, multiplied by the Aggregate Liquidation Preference of such underlying shares of CERo preferred
stock, and divided by $10.00, with the exercise price per share for such warrant equal to (A) the current aggregate
exercise price of such warrant (the current exercise price per share of CERo preferred stock applicable to the corresponding warrant
immediately prior to the Effective Time, multiplied by the number of shares of CERo preferred stock issuable upon exercise
thereof), divided by (B) the number of shares of Class A common stock issuable upon exercise thereof. Subject
to certain exceptions, such terms and conditions applicable to a New CERo warrant will be the same terms and conditions as were applicable
to a CERo warrant immediately prior to the Effective Time. The Company will issue an aggregate of approximately 5.0 million shares
of Class A common stock to the holders of CERo common stock and CERo preferred stock as consideration in the Business Combination.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Sponsor
Support Agreement
In
connection with the execution of the Business Combination Agreement, the Sponsor, as the sole holder of the Class B common stock,
and each of the Company’s officers and directors entered into a support agreement with the Company and CERo (the “Sponsor
Support Agreement”). Under the Sponsor Support Agreement, the Sponsor agreed to vote, at any meeting of the stockholders of the
Company and in any action by written consent of the stockholders of the Company, all of its shares of Class B common stock (together
with any other equity securities of the Company that it holds of record or beneficially, as of the date of the Sponsor Support Agreement,
or of which it acquires record or beneficial ownership after the date thereof, the “Subject Company Shares”) (i) in favor
of (a) the Business Combination Agreement and the transactions contemplated thereby and (b) the other proposals that the Company
and CERo agreed in the Business Combination Agreement shall be submitted at such meeting for approval by the Company’s stockholders
(together with the proposal to obtain the Company Stockholder Approval, the “Required Transaction Proposals”) and (ii) against
any proposal that conflicts or materially impedes or interferes with any Required Transaction Proposals or that would adversely affect
or delay the Business Combination. The Sponsor Support Agreement also prohibits the Sponsor from, among other things and subject to certain
exceptions, transferring any Subject Company Shares held by the Sponsor or taking any action that would have the effect of preventing
or materially delaying the Sponsor from performing its obligations under the Sponsor Support Agreement, until the earlier of the Closing
or the termination of the Sponsor Support Agreement according to its terms. On July 3, 2023, the Sponsor delivered notice of conversion
of an aggregate of 4,596,250 shares of Class B common stock into an equal number of shares of Class A common stock. Following the Conversion,
the Sponsor held an aggregate of 5,296,246 shares of Class A common stock, all of which are subject to the Sponsor Support Agreement.
CERo
Support Agreements
In
connection with the execution of the Business Combination Agreement, certain CERo stockholders (the “CERo Supporting Stockholders”)
entered into support agreements with CERo (the “CERo Support Agreements”). Under the CERo Support Agreements, each CERo Supporting
Stockholder agreed as promptly as practicable following the time at which the Registration Statement/Proxy Statement shall have been
declared effective and made available to such CERo Supporting Stockholders, to execute and deliver a written consent with respect to
all outstanding shares of CERo common stock and CERo preferred stock held by such CERo Supporting Stockholder (the “Subject CERo
Shares”) approving the Business Combination Agreement and the transactions contemplated thereby (including the Business Combination).
In addition to the foregoing, each CERo Supporting Stockholder agreed that, at any meeting of the holders of CERo capital stock, each
such CERo Supporting Stockholder will appear at the meeting, in person or by proxy, and cause its Subject CERo Shares to be counted as
present thereat for purposes of calculating a quorum and voted (i) to approve and adopt the Business Combination Agreement, the
transactions contemplated thereby (including the Business Combination), and any other matters necessary or reasonably requested by CERo
for consummation of the Business Combination, and (ii) against any proposal that conflicts or materially impedes or interferes with,
or would adversely affect or delay, the consummation of the transactions contemplated by the Business Combination Agreement (including
the Business Combination).
Note
7 — Stockholders’ Deficit
Common
Stock
Class A
common stock — The Company is authorized to issue 60,000,000 shares of Class A common stock with a par value of $0.0001
per share. As of December 31, 2023 and 2022, there were 5,481,250 and 885,000 shares of Class A common stock issued and outstanding
(excluding 764,957 and 1,288,298 shares subject to possible redemption), respectively.
Class B
common stock — The Company is authorized to issue 10,000,000 shares of Class B common stock with a par value of $0.0001
per share. Holders of Class B common stock are entitled to one vote for each share. On July 3, 2023, the Sponsor delivered notice
of conversion of an aggregate of 4,596,250 shares of Class B common stock into an equal number of shares of Class A common stock. As
of December 31, 2023 and 2022, there were 0 and 4,596,250 shares of Class B common stock issued and outstanding.
Prior
to the consummation of an initial business combination, only holders of shares of Class B common stock will have the right to vote
on the election of directors. Holders of shares of Class A common stock and shares of Class B common stock will vote together
as a single class on all other matters submitted to a vote of stockholders.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Preferred
stock — The Company is authorized to issue 1,000,000 shares of preferred stock with such designations,
voting and other rights and preferences as may be determined from time to time by the Company’s board of directors. As of December
31, 2023 and 2022, there were no shares of preferred stock issued or outstanding.
Warrants
— At December 31, 2023 and 2022, there were 8,750,000 Public Warrants and 442,500 Private Placement Warrants
outstanding. The Public Warrants will become exercisable 30 days after the completion of a business combination. No warrants
will be exercisable for cash unless the Company has an effective and current registration statement covering the common stock
issuable upon exercise of the warrants and a current prospectus relating to such common stock.
Notwithstanding
the foregoing, if a registration statement covering the common stock issuable upon exercise of the Public Warrants is not effective within
a specified period following the consummation of a business combination, warrant holders may, until such time as there is an effective
registration statement and during any period when the Company shall have failed to maintain an effective registration statement, exercise
warrants on a cashless basis pursuant to the exemption provided by Section 3(a)(9) of the Securities Act, provided that such exemption
is available. If that exemption, or another exemption, is not available, holders will not be able to exercise their warrants on a cashless
basis. The Public Warrants will expire five years after the completion of a business combination or earlier upon redemption or liquidation.
Once
the warrants become exercisable, the Company may redeem the Public Warrants:
| ● | in
whole and not in part; |
| ● | at a price of $0.01 per warrant; |
| ● | upon not less than 30 days’ prior written notice of redemption; |
| ● | if, and only if, the reported last sale price of Class A common stock equals or exceeds $18.00 per share (as adjusted for stock splits, stock dividends, reorganizations and recapitalizations), for any 20 trading days within a 30-trading-day period commencing at any time after the warrants become exercisable and ending on the third business day prior to the notice of redemption to warrant holders; and |
| ● | if,
and only if, there is a current registration statement in effect with respect to the shares
of Class A common stock underlying the warrants. |
If
the Company calls the Public Warrants for redemption, management will have the option to require all holders that wish to exercise the
Public Warrants to do so on a “cashless basis,” as described in the warrant agreement.
The
Private Placement Warrants are identical to the Public Warrants underlying the Units sold in the IPO, except that the Private Placement
Warrants and the common stock issuable upon the exercise of the Private Placement Warrants will not be transferable, assignable, or salable
until after the completion of a business combination, subject to certain limited exceptions. The Private Placement Warrants will be redeemable
by the Company and exercisable by such holders on the same basis as the Public Warrants.
The
exercise price and number of shares of common stock issuable upon exercise of the warrants may be adjusted in certain circumstances including
in the event of a stock dividend, extraordinary dividend or recapitalization, reorganization, merger, or consolidation. However, the
warrants will not be adjusted for issuances of common stock at a price below their respective exercise prices, other than as set forth
below. Additionally, in no event will the Company be required to net cash settle the warrants. If the Company is unable to complete a
business combination within the Combination Period and the Company liquidates the funds held in the Trust Account, holders of warrants
will not receive any of such funds with respect to their warrants, nor will they receive any distribution from the Company’s assets
held outside of the Trust Account with respect to such warrants. Accordingly, the warrants may expire worthless.
In
addition, if the Company issues additional common stock or equity-linked securities for capital raising purposes in connection with the
closing of a business combination at an issue price or effective issue price of less than $9.20 per share of common stock (with such
issue price or effective issue price to be determined in good faith by the Company’s board of directors, and in the case of any
such issuance to the Initial Stockholders or their affiliates, without taking into account any Founder Shares held by them prior to such
issuance) (the “Newly Issued Price”), and (y) the aggregate gross proceeds from such issuances represent more than 60%
of the total equity proceeds, and interest thereon, available for the funding of a business combination on the date of the consummation
of a business combination (net of redemptions), and (z) the volume weighted-average trading price of the Company’s common
stock during the 20-trading-day period starting on the trading day prior to the day on which the Company consummates a business
combination (such price, the “Market Value”) is below $9.20 per share, the exercise price of the warrants will be adjusted
(to the nearest cent) to be equal to 115% of the greater of (i) the Market Value or (ii) the Newly Issued Price, and the $18.00
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Note
8 — Fair Value Measurements
The
fair value of the Company’s financial assets and liabilities reflects management’s estimate of amounts that the Company would
have received in connection with the sale of the assets or paid in connection with the transfer of the liabilities in an orderly transaction
between market participants at the measurement date. In connection with measuring the fair value of its assets and liabilities, the Company
seeks to maximize the use of observable inputs (market data obtained from independent sources) and to minimize the use of unobservable
inputs (internal assumptions about how market participants would price assets and liabilities). The following fair value hierarchy is
used to classify assets and liabilities based on the observable inputs and unobservable inputs used in order to value the assets and
liabilities:
Level 1:
Quoted prices in active markets for identical assets or liabilities. An active market for an asset or liability is a market in which
transactions for the asset or liability occur with sufficient frequency and volume to provide pricing information on an ongoing basis.
Level 2:
Observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar
assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.
Level 3:
Unobservable inputs based on the Company’s assessment of the assumptions that market participants would use in pricing the asset
or liability.
At
December 31, 2023, the assets held in the Trust Account were held in money market funds. All of the Company’s investments held
in the Trust Account are classified as trading securities.
The
following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring
basis at December 31, 2023, and indicates the fair value hierarchy of the valuation inputs the Company utilized to determine such fair
value. At December 31, 2022 there were no assets or liabilities measured at fair value.
December
31, 2023
| |
Level | | |
Quoted
Prices in Active Markets (Level 1) | | |
Significant
Other Observable Inputs (Level 2) | | |
Significant
Other Unobservable Inputs (Level 3) | |
Assets: | |
| | |
| | |
| | |
| |
Money
Market Funds | |
| 1 | | |
$ | 8,436,311 | | |
| — | | |
| — | |
Note
9 — Subsequent Events
The
Company evaluated subsequent events and transactions that occurred up to the date the financial statements were issued. Based upon this
review, other than described below, the Company did not identify any other subsequent events that would have required adjustment or disclosure
in the financial statements.
On January 3, 2024, the Company held a special meeting of stockholders
(the “Third Special Meeting”). At the Third Special Meeting, the Company’s stockholders approved an amendment (the “Third
IMTA Amendment”) to the IMTA, as amended by the First IMTA Amendment and the Second IMTA Amendment, and an amendment (the “Third
Charter Amendment”) to the Charter, as amended by the First Charter Amendment and the Second Charter Amendment, to extend the business
combination period up to three times for one month each time (the “Third Extension”).
In connection with the approval
of the Third Extension, the Sponsor deposited $22,600 in the Trust Account, and holders of 11,625 Public Shares exercised redemption
rights requiring the Company to make a series of payments of an aggregate of $128,133 for an aggregate $11.02 per redeemed share. As
a result, following satisfaction of such redemptions, the Company had 6,234,582 shares of Class A common stock outstanding, of which
(i) 753,332 were Public Shares, which were entitled to receive a pro rata portion of the remaining funds in the Company’s Trust
Account in connection with its initial Business Combination, a liquidation or certain other events, (ii) 4,596,250 were Class A common
stock issued upon the conversion of an equal number of shares of the Class B common stock, which did not have redemption rights, and
(iii) 885,000 were Private Placement Shares, which did not have redemption rights. As a result of the deposit described above, such payments
and accrual of interest, the balance in the trust account as of the last extension payment was approximately $8.4 million.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Business Combination
On
February 5, 2024, the parties entered into Amendment No. 1 to the Business Combination Agreement to, among other things, (i) remove the
minimum cash condition, (ii) modify the stock-price based milestones such that (a) the trading price condition for the First Level Earnout
Target shall be reset from $12.50 to 125% of the reset Conversion Price of the Series A Preferred Stock and (b) the trading price condition
for the Second Level Earnout Target shall be reset from $15.00 to 150% of the reset Conversion Price of the Series A Preferred Stock,
and (iii) increase the aggregate number of shares of Class A common stock issuable to the stockholders of CERo in connection with the
Business Combination from 4,651,704 shares to 5,000,000 shares. Such number of shares is in addition to up to 1,200,000 shares issuable
upon satisfaction of certain earn-out conditions and 382,651 shares issuable upon exercise of rollover options or warrants.
On February 8, 2024, the Company held a special meeting of stockholders
(the “Fourth Special Meeting”). At the Fourth Special Meeting, the Company’s stockholders adopted and approved (i) the
Business Combination Agreement, pursuant to which Merger Sub merged with and into CERo, with CERo surviving as a wholly-owned subsidiary
of the Company and approved the Business Combination and the other transactions and ancillary documents contemplated by and required for
the Business Combination; (ii) on a non-binding advisory basis, certain changes to the Charter, including the name change to CERo Therapeutics
Holdings, Inc., share authorizations, and others; (iii) the issuance of Class A common stock to CERo stockholders pursuant to the Business
Combination Agreement; (iv) the election of five directors; and (v) the 2024 Equity Incentive Plan and the 2024 Employee Stock Purchase
Plan, contingent of the consummation of the Business Combination.
In connection with the approval of the Business Combination, holders
of 671,285 shares of Class A common stock, exercised redemption rights. As a result, following satisfaction of such redemptions, we had
5,563,297 shares of Class A common stock outstanding, of which (i) 82,047 were shares of Class A common stock issued to the public in
our IPO, which shares of Class A common stock were entitled to receive a pro rata portion of the remaining funds in our Trust Account
in connection with its initial business combination, a liquidation or certain other events, (ii) 4,596,250 were shares of Class A common
stock issued upon the conversion of an equal number of shares of our Class B common stock acquired by Sponsor prior to our IPO, which
shares of Class A common stock did not have redemption rights, and (iii) 885,000 were shares of Class A common stock included in the private
placement units acquired in the private placement by the Sponsor and other investors concurrent with our IPO, which shares of Class A
common stock did not have redemption rights. On February 14, 2024, we made a series of payments of an aggregate of $7,456,463.30 to holders
of redeemed Class A common stock (an aggregate of $11.11 per redeemed share).
On February 13, 2024, the parties entered into Amendment No. 2 to the
Business Combination Agreement to create two additional pools of earnout shares of Class A common stock, one pool of which contained 875,000
shares, which were fully vested at closing of the Business Combination and which were issued as an offset to the agreement by Sponsor
to forfeit an offsetting number of shares, and one pool of which will contain 1,000,000 shares, which will be fully vested upon the achievement
of certain regulatory milestone-based earnout targets and make certain other technical changes to the timing and process for issuance
of the 1,200,000 shares of Class A common stock subject to the other earn-out conditions set forth in the Business Combination Agreement.
The
Business Combination closed on February 14, 2024, at which time the following occurred:
1.
Each outstanding share of the Company’s preferred stock was converted into the number of shares of Class A common stock
calculated by dividing the liquidation preference by $10.00.
2. Each outstanding
share of the Company’s common stock was converted into the number of shares of Class A common stock calculated by multiplying
each share by the Exchange Ratio. The Exchange Ratio of 0.064452 was calculated by first subtracting the aggregate liquidation
preference of outstanding preferred shares from $50 million, then dividing the result by the number of shares of the Company’s
common stock outstanding and dividing by $10.00 per share.
3. Each holder of the Company’s
common stock received a pro rata portion of up to 1.2 million Earnout Shares, 1,000,000 of which are subject to vesting upon the achievement
of certain stock price-based earnout targets and 200,000 of which are subject to vesting upon a change of control, respectively.
4. Certain holders of the
Company’s common stock received a pro rata portion of 875,000 Earnout Shares, which became fully vested upon the closing of the
Business Combination.
5. Certain holders of the
Company’s common stock received a pro rata portion of up to 1.0 million Earnout Shares, which are subject to vesting upon the Company’s
filing an investigational new drug application (“IND”) with the FDA.
6. Each outstanding Company
option was converted into an option to purchase a number of shares of Class A common stock, equal to the Company’s common shares
underlying the option multiplied by the Exchange Ratio, at an exercise price per share equal to the Company option exercise price divided
by the Exchange Ratio.
7. Each warrant to purchase
CERo preferred stock was converted into a warrant to acquire a number of shares of Class A common stock obtained by dividing the warrant
as-if-exercised liquidation preference by $10.00, with the exercise price equal to the total CERo warrant exercise amount divided by the
number of shares of Class A common stock issuable upon exercise.
8. The CERo Notes automatically converted into shares of Series A Preferred
Stock.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
PIPE
Financing
In February 2024, New CERo consummated a private placement of 10,080
shares of New CERo Series A Preferred Stock, par value $0.0001 per share (the “Series A Preferred Stock”), warrants to purchase
612,746 shares of Common Stock (the “Common Warrants”) and warrants to purchase 2,500 shares of Series A Preferred Stock (the
“Preferred Warrants” and, together with the Common Warrants, the “PIPE Warrants”), pursuant to the Amended and
Restated Securities Purchase Agreement, dated February 14, 2024, by and among the Company, CERo and certain accredited investors (the
“Initial Investors”) for aggregate cash proceeds to New CERo of approximately $9.98 million. In April 2024, New CERo consummated
a private placement of 626 shares of Series B convertible preferred stock, par value $0.0001 per share (“Series B Preferred Stock”),
pursuant to the Securities Purchase Agreement, dated March 28, 2024, by and among New CERo and certain accredited investors (the “Additional
Investors” and, together with the Initial Investors, the “PIPE Investors”), for aggregate cash proceeds to New CERo
of approximately $0.5 million. A portion of such Series A Preferred Stock was issued as consideration for the cancellation of outstanding
indebtedness or securities of the Company or CERo, including a promissory note of the Company and certain convertible bridge notes of
CERo. Such transactions collectively are referred to as the “PIPE Financing.”
In connection with the PIPE
Financing, New CERo entered into the PIPE Registration Rights Agreements with the PIPE Investors. The terms of the PIPE Registration Rights
Agreements require New CERo to register the number of shares of common stock, par value $0.0001 per share (“Common Stock”)
equal to the sum of (i) 200% of the maximum number of Common Stock issuable upon conversion of the Series A Preferred Stock and Series
B Preferred Stock (assuming for purposes hereof that (w) all the Preferred Warrants have been exercised in full, (x) the Series A Preferred
Stock and Series B Preferred Stock is convertible at the Alternate Conversion Price (as defined in the Series A Certificate of Designations
and Series B Certificate of Designations) assuming an Alternate Conversion Date (as defined in the Series A Certificate of Designations
and Series B Certificate of Designations) of such date of determination, and (y) any such conversion shall not take into account any limitations
on the conversion of the Series A Preferred Stock and Series B Preferred Stock set forth in the Series A Certificate of Designations and
the Series B Certificate of Conversions, respectively) and (ii) the maximum number of Warrant Common Shares issuable upon exercise of
the Common Warrants (without taking into account any limitations on the exercise of the Common Warrants set forth therein). In addition,
New CERo entered into a side letter with Keystone, pursuant to which New CERo agreed to make a payment of $1.0 million to Keystone, which
amount reflects an original issue discount to Keystone, and to reimburse $150,000 of legal expenses incurred thereby. Additionally, the
Company entered into a share reallocation agreement (the “Share Reallocation Agreement”) with the Sponsor and an institutional
investor party thereto (a “Share Reallocation Investor”). Under the Share Reallocation Agreement, (i) the Share Reallocation
Investor agreed to purchase an aggregate of 1,500 shares of Series A Preferred Stock for an aggregate purchase price of $1.5 million in
accordance with the Securities Purchase Agreement, and (ii) the Sponsor agreed to forfeit an aggregate of 250,000 shares of Class A Common
Stock held by the Sponsor for no additional consideration other than the commitments and undertakings of the Share Reallocation Investor
made to the Company, in each case, on or promptly following the consummation of the Business Combination at the Closing.
Fee
Modification
Prior
to the close of the Business Combination, the Company entered into fee modification agreements with certain third-party vendors and service
providers, pursuant to which such vendors received an aggregate of 1,629,500 shares of Common Stock in lieu of certain payments due to
such vendors. As a result, the cash expenses payable at Closing were reduced by approximately $8.54 million.
In
particular, the Company entered into a fee modification agreement with CCM, pursuant to which CCM forfeited such fees and the Company
issued an aggregate of 1,200,000 shares of Common Stock, with 1,000,000 of such shares being subject to forfeiture unless New CERo conducts
a capital-raising transaction within nine months of the Closing, pursuant to which New CERo shall issue and sell securities in an aggregate
amount of at least $25.0 million, Affiliates of CCM have and manage investment vehicles with a passive investment in the Sponsor.
Equity
Line of Credit – Keystone Capital Partners, LLC (“Keystone”)
On February 14, 2024, as a condition to the closing of the PIPE Financing,
New CERo entered into a common stock purchase agreement (the “Common Stock Purchase Agreement”) with Keystone, pursuant to
which New CERo may sell and issue, and Keystone is obligated to purchase, up to the lesser of (i) an aggregate of up to 2,977,070 shares
of newly issued shares of Common Stock and (ii) the Exchange Cap (as defined below).
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
As consideration for
Keystone’s commitment to purchase shares of Common Stock pursuant to the Common Stock Purchase Agreement, at Closing, New CERo
issued 119,050 shares of Common Stock to Keystone. In addition, New CERo has agreed to issue an additional $250,000 of shares of
Common Stock to Keystone at each of the 90- and 180-day anniversaries of the effectiveness of the registration statement on Form S-1
with respect to the resale of the shares issuable pursuant to the Common Stock Purchase Agreement, with the number of such shares
determined based upon the average of the daily VWAP (as defined below) for each of the five trading days immediately prior to such
90- or 180-day anniversary.
New
CERo does not have a right to commence any sales of Common Stock to the Investor under the Common Stock Purchase Agreement until the
time when all of the conditions to the New CERo’s right to commence sales of Common Stock to the Investor set forth in the Common
Stock Purchase Agreement have been satisfied, including that a registration statement covering the resale of such shares is declared
effective by the SEC and the final form of prospectus contained therein is filed with the SEC (the “Commencement Date”).
Over the 36-month period from and after the Commencement Date, New CERo will control the timing and amount of any sales of Common Stock
to Keystone. Actual sales of shares of Common Stock to Keystone under the Common Stock Purchase Agreement will depend on a variety of
factors to be determined by New CERo from time to time, including, among others, market conditions, the trading price of the Common Stock
and determinations by the Company as to the appropriate sources of funding and New CERo’s operations.
At
any time from and after the Commencement Date, on any business day on which the closing sale price of the Common Stock is equal to or
greater than $1.00 (the “Purchase Date”), New CERo may direct Keystone to purchase a specified number of shares of Common
Stock (a “Fixed Purchase”) not to exceed 10,000 shares at a purchase price equal to the lesser of 90% of (i) the daily volume
weighted average price (the “VWAP”) of the Common Stock for the five trading days immediately preceding the applicable Purchase
Date for such Fixed Purchase and (ii) the closing price of a share of Common Stock on the applicable Purchase Date for such Fixed Purchase
during the full trading day on such applicable Purchase Date.
In
addition, at any time from and after the Commencement Date, on any business day on which the closing sale price of the Common Stock is
equal to or greater than $1.00 and such business day is also the Purchase Date for a Fixed Purchase of the maximum allowable amount of
shares of Common Stock (the “VWAP Purchase Date”), New CERo may also direct Keystone to purchase, on the immediately following
business day, an additional number of shares of Common Stock in an amount up to a defined limit at a purchase price equal to the lesser
of 90% of (i) the closing sale price of the Common Stock on the applicable VWAP Purchase Date and (ii) the VWAP during the VWAP Purchase
Date between the opening of trading and the purchase termination time. At any time from and after the Commencement Date, on any business
day that is also the VWAP Purchase Date for a VWAP Purchase, New CERo may also direct Keystone to purchase, on such same business day,
an additional number of shares of Common Stock in an amount up to a defined limit (an “Additional VWAP Purchase”) at a purchase
price equal to the lesser of 90% of (i) the closing sale price of the Common Stock on the applicable Additional VWAP Purchase Date and
(ii) the VWAP during the measurement time on the Additional VWAP Purchase Date.
In
no event shall New CERo issue to Keystone under the Common Stock Purchase Agreement more than 19.99% of the total number of shares of
Common Stock outstanding immediately prior to the execution of the Common Stock Purchase Agreement (the “Exchange Cap”),
unless (i) the Company obtains the approval of the issuance of such shares by its stockholders in accordance with the applicable stock
exchange rules or (ii) sales of Common Stock are made at a price equal to or in excess of the lower of (A) the closing price immediately
preceding the delivery of the applicable notice to the Investor and (B) the average of the closing prices of the Common Stock for the
five business days immediately preceding the delivery of such notice (in each case plus an incremental amount to take into account the
Commitment Shares, such that the sales of such Common Stock to Keystone would not count toward the Exchange Cap because they are “at
market” under applicable stock exchange rules.
Concurrent
with the execution of the Common Stock Purchase Agreement, the Company entered into a registration rights agreement with Keystone (the
“ELOC Registration Rights Agreement”), pursuant to which New CERo agreed to provide Keystone with customary registration
rights related to the shares issued under the ELOC Registration Rights Agreement.
Equity
Line of Credit – Arena Business Solutions Global SPC II, Ltd (“Arena”)
On
February 23, 2024, New CERo entered into a purchase agreement (the “Purchase Agreement”) with Arena, under which Arena has
committed to purchase up to $25 million (the “Commitment Amount”) of New CERo’s shares of Common Stock, subject to
the satisfaction of the conditions in the Purchase Agreement.
PHOENIX
BIOTECH ACQUISITION CORP.
NOTES
TO FINANCIAL STATEMENTS
DECEMBER
31, 2023
Such
sales of Common Stock, if any, will be subject to certain limitations, and may occur from time to time at New CERo’s sole discretion
over the period commencing on the termination of the Common Stock Purchase Agreement and expiring approximately 36 months following such
termination, provided that a Registration Statement (as defined below) is and remains effective, and the other conditions set forth in
the Purchase Agreement are satisfied. New CERo will control the timing and amount of any sales of Common Stock to Arena. Actual sales
of shares of Common Stock to Arena under the Purchase Agreement will depend on a variety of factors to be determined by New CERo from
time to time, including, among others, market conditions, the trading price of the Common Stock and determinations by the Company as
to the appropriate sources of funding and New CERo’s operations.
On any trading day, New CERo may direct Arena to purchase amounts of
its Common Stock up to the Commitment Amount. The maximum amount that the Company may specify in any one Advance Notice is equal to: (A)
if the Advance Notice is received by 8:30 a.m. Eastern time, then the maximum amount that the Company may specify is equal to the lesser
of (i) an amount equal to 60% of the average Daily Value Traded of the Common Stock on the ten trading days immediately preceding such
Advance Notice, or (ii) $20.0 million; and (B) if the Advance Notice is received after 8:30 a.m. Eastern time but prior to 10:30 a.m.
Eastern time, then the maximum amount that the Company may specify in an Advance Notice is equal to the lesser of: (i) an amount equal
to 30% of the average Daily Value Traded of the Common Stock on the ten trading days immediately preceding such Advance Notice, or (ii)
$15.0 million. For these purposes, “Daily Value Traded” is the product obtained by multiplying the daily trading volume of
New CERo Common Stock on Nasdaq during regular trading hours by the VWAP for that trading day.
Under
the applicable rules of Nasdaq and the Purchase Agreement, New CERo will not sell or issue to Arena shares of Common Stock, inclusive
of the Commitment Fee Shares (as defined below), in excess of the Exchange Cap, unless the Company obtains stockholder approval to issue
shares of Common Stock in excess of the Exchange Cap. In any event, New CERo may not issue or sell any shares of Common Stock under the
Purchase Agreement if such issuance or sale would breach any applicable Nasdaq rules.
The
Purchase Agreement also prohibits the Company from directing Arena to purchase any shares of Common Stock if those shares, when aggregated
with all other shares of Common Stock then beneficially owned by Arena and its affiliates as a result of purchases under the Purchase
Agreement, would result in Arena and its affiliates having beneficial ownership of more than the 4.99% of the then-outstanding Common
Stock.
The
purchase price of the shares of Common Stock will be equal to 90% of the lower of (i) the closing sale price of the Common Stock on the
purchase date (ii) VWAP of the Common Stock during the purchase date and (iii) the arithmetic average of the three lowest closing prices
of the Common Stock during the ten consecutive trading days ending on the trading day immediately preceding the purchase date.
As
consideration for Arena’s irrevocable commitment to purchase Common Stock upon the terms of the Purchase Agreement, New CERo agreed
to issue a number of shares of Common Stock (the “Commitment Fee Shares”) equal to 500,000 divided by the simple average
of the daily VWAP of the Common Stock during the five trading days immediately preceding the effectiveness of the registration statement
with respect to the resale by Keystone of the shares of Common Stock issuable pursuant to the Common Stock Purchase Agreement (the “Registration
Statement”). In addition, New CERo has granted Arena customary registration rights related to the shares issued under the Purchase
Agreement, and has agreed to include the resale by Arena of the Commitment Fee Shares on the Registration Statement.
F-25
No
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Exhibit 3.6
CERTIFICATE
OF DESIGNATIONS
OF RIGHTS AND PREFERENCES OF
SERIES B CONVERTIBLE PREFERRED STOCK
OF
CERO THERAPEUTICS HOLDINGS, INC.
I,
Charles Carter, hereby certify that I am the Chief Financial Officer of CERo Therapeutics Holdings, Inc. (the “Company”),
a corporation organized and existing under the Delaware General Corporation Law (the “DGCL”), and further do hereby
certify:
That
pursuant to the authority expressly conferred upon the Board of Directors of the Company (the “Board”) by the Company’s
Amended and Restated Certificate of Incorporation, as amended (the “Certificate of Incorporation”), and Section 151(g)
of the DGCL, the Board on March 29, 2024 adopted the following resolution determining it desirable and in the best interests of the Company
and its stockholders for the Company to create a series of six hundred and twenty-six (626) shares of preferred stock designated as “Series
B Convertible Preferred Stock”, none of which shares have been issued, to be issued pursuant to the Securities Purchase Agreement
(as defined in below), in accordance with the terms of the Securities Purchase Agreement:
RESOLVED,
that pursuant to the authority vested in the Board, in accordance with the provisions of the Certificate of Incorporation, a series of
preferred stock, par value $0.0001 per share, of the Company be and hereby is created pursuant to this certificate of designations (this
“Certificate of Designations”), and that the designation and number of shares established pursuant hereto and the
voting and other powers, preferences and relative, participating, optional or other rights of the shares of such series and the qualifications,
limitations and restrictions thereof are as follows:
TERMS
OF SERIES B CONVERTIBLE PREFERRED STOCK
1. Designation
and Number of Shares. There shall hereby be created and established a series of preferred stock of the Company designated as “Series
B Convertible Preferred Stock” (the “Series B Convertible Preferred Stock”). The authorized number of shares
of Series B Convertible Preferred Stock (the “Preferred Shares”) shall be six hundred twenty-six (626) shares. Each
Preferred Share shall have a par value of $0.0001 per share. Capitalized terms not defined herein shall have the meaning as set forth
in Section 40 below.
2. Ranking.
Except to the extent that the Required Holders (as defined in the Securities Purchase Agreement) expressly consent to the creation of
Parity Stock (as defined below) or Senior Preferred Stock (as defined below) in accordance with Section 20, or the requisite holders
of the outstanding shares of the Company’s Series A Convertible Preferred Stock (the “Series A Convertible Preferred Stock”)
consent to the creation of Parity Stock or Senior Preferred Stock pursuant to Section 20 of the Series A Certificate of Designations
(as defined herein), all shares of capital stock of the Company shall be junior in rank to all Preferred Shares with respect to the preferences
as to dividends, distributions and payments upon the liquidation, dissolution and winding up of the Company (such junior stock is referred
to herein collectively as “Junior Stock”). For the avoidance of doubt, the Preferred Shares will, with respect to
dividend rights and rights on liquidation, winding-up and dissolution, rank (A) junior to the Senior Preferred Stock, (B) on parity with
the Parity Stock, including the Series A Convertible Preferred Stock, and (C) senior to the Junior Stock. The rights of all such shares
of capital stock of the Company shall be subject to the rights, powers, preferences and privileges of the Preferred Shares. Without limiting
any other provision of this Certificate of Designations, without either (x) the prior express consent of the Required Holders, voting
separately as a single class, or (y) the consent of the requisite holders of the outstanding shares of Series A Convertible Preferred
Stock pursuant to the Series A Certificate of Designations (such a consent, a “Series A Holder Consent”), the Company
shall not hereafter authorize or issue any additional or other shares of capital stock that is (i) of senior rank to the Preferred Shares
in respect of the preferences as to dividends, distributions and payments upon the liquidation, dissolution and winding up of the Company
(collectively, the “Senior Preferred Stock”) (ii) of pari passu rank to the Preferred Shares in respect of the preferences
as to dividends, distributions and payments upon the liquidation, dissolution and winding up of the Company (other than the Permitted
Additional Preferred Shares (as defined in the Securities Purchase Agreement)) (collectively, the “Parity Stock”)
or (iii) any Junior Stock having a maturity date or any other date requiring redemption or repayment of such shares of Junior Stock that
is prior to the first anniversary of the Initial Issuance Date. In the event of the merger or consolidation of the Company with or into
another corporation, the Preferred Shares shall maintain their relative rights, powers, designations, privileges and preferences provided
for herein and no such merger or consolidation shall result inconsistent therewith.
3. Dividends.
In addition to Section 11, Section 12 and/or Section 19 below, as applicable, subject to the senior rights of the Senior Preferred Stock,
and pari passu with the holders of shares of Parity Stock, from and after the first date of issuance of any Preferred Shares (the “Initial
Issuance Date”), each holder of a Preferred Share (each, a “Holder” and collectively, the “Holders”)
shall be entitled to receive dividends (“Dividends”) when and as declared by the Board, from time to time, in its
sole discretion, which Dividends shall be paid by the Company out of funds legally available therefor, payable, subject to the conditions
and other terms hereof, in cash, in securities of the Company or any other entity, or using assets as determined by the Board on the
Stated Value of such Preferred Share.
4. Conversion.
At any time after the Initial Issuance Date, each Preferred Share shall be convertible into validly issued, fully paid and non-assessable
shares of Common Stock (the “Conversion Shares”), on the terms and conditions set forth in this Section 4.
(a) Holder’s
Conversion Right. Subject to the provisions of Section 5(a), at any time or times on or after the Initial Issuance Date, each Holder
shall be entitled to convert any portion of the outstanding Preferred Shares held by such Holder into validly issued, fully paid and
non-assessable Conversion Shares in accordance with Section 4(c) at the Conversion Rate (as defined below). The Company shall not issue
any fraction of a share of Common Stock upon any conversion. If the issuance would result in the issuance of a fraction of a share of
Common Stock, the Company shall round such fraction of a share of Common Stock up to the nearest whole share. The Company shall pay any
and all transfer, stamp, issuance and similar taxes, costs and expenses (including, without limitation, fees and expenses of the Company’s
transfer agent (the “Transfer Agent”)) that may be payable with respect to the issuance and delivery of Common Stock
upon conversion of any Preferred Shares.
(b) Conversion
Rate. Except as otherwise provided herein, the number of Conversion Shares issuable upon conversion of any Preferred Share pursuant
to this Section 4 shall be determined by dividing (x) the Conversion Amount of such Preferred Share by (y) the Conversion Price (the
“Conversion Rate”).
For
purposes of this Certificate of Designations, the term “Conversion Amount” means, with respect to each Preferred Share,
as of the applicable date of determination, the sum of (1) the Stated Value thereof plus (2) any Additional Amount thereon as
of such date of determination plus (3) any other amounts owed to such Holder pursuant to this Certificate of Designations or any
other Transaction Document.
For
purposes of this Certificate of Designations, the term “Conversion Price” means, with respect to each Preferred Share,
as of any Conversion Date or other date of determination, $10.00, subject to adjustment as provided herein.
(c) Mechanics
of Conversion. The conversion of each Preferred Share shall be conducted in the following manner:
(i) Optional Conversion. To convert one or more Preferred Shares into Conversion Shares
on any date (a “Conversion Date”), a Holder shall deliver (whether via electronic mail or otherwise), for receipt
on or prior to 11:59 p.m., New York time, on such date, a copy of an executed notice of conversion of the Preferred Share(s) subject
to such conversion in the form attached hereto as Exhibit I (the “Conversion Notice”) to the Company.
If required by Section 4(c)(ii), within two (2) Trading Days following a conversion of any such Preferred Shares as aforesaid, such Holder
shall surrender to a nationally recognized overnight delivery service for delivery to the Company the original certificates, if any,
representing the Preferred Shares (the “Preferred Share Certificates”) so converted as aforesaid (or an indemnification
undertaking with respect to the Preferred Shares in the case of its loss, theft or destruction as contemplated by Section 22(b)). On
or before the first (1st) Trading Day following the date of receipt of a Conversion Notice, the Company shall transmit by
electronic mail an acknowledgment of confirmation and representation as to whether such shares of Common Stock may then be resold pursuant
to Rule 144 or an effective and available registration statement, in the form attached hereto as Exhibit II, of receipt
of such Conversion Notice to such Holder and the Transfer Agent, which confirmation shall constitute an instruction to the Transfer Agent
to process such Conversion Notice in accordance with the terms set forth herein. On or before the first (1st) Trading Day
following each date on which the Company has received a Conversion Notice (or such earlier date as required pursuant to the 1934 Act
or other applicable law, rule or regulation for the settlement of a trade initiated on the applicable Conversion Date of such Conversion
Shares issuable pursuant to such Conversion Notice) (the “Share Delivery Deadline”), the Company shall (1) provided
that the Transfer Agent is participating in the Depository Trust Company (“DTC”) Fast Automated Securities Transfer
Program (“FAST”) and such shares of Common Stock (i) (A) may then be sold by the applicable Holder pursuant to an
available and effective registration statement and (B) such Holder provides such documentation or other information evidencing the sale
of the shares of Common Stock as the Company, the Transfer Agent or legal counsel to the Company shall reasonably request (which, for
the avoidance of doubt, shall not include the requirement of a medallion guarantee or a legal opinion) or (ii) may be sold by such Holder
pursuant to Rule 144 of the 1933 Act, as applicable (the “Resale Eligibility Conditions”), credit such aggregate number
of Conversion Shares to which such Holder shall be entitled pursuant to such conversion to such Holder’s or its designee’s
balance account with DTC through its Deposit/Withdrawal at Custodian system, or (2) if the Transfer Agent is not participating in FAST
or the Resale Eligibility Conditions are not satisfied, upon the request of such Holder, issue and deliver (via reputable overnight courier)
to the address as specified in such Conversion Notice, a certificate, registered in the name of such Holder or its designee, for the
number of Conversion Shares to which such Holder shall be entitled. If the number of Preferred Shares represented by the Preferred Share
Certificate(s) submitted for conversion pursuant to Section 4(c)(ii) is greater than the number of Preferred Shares being converted,
then the Company shall, as soon as practicable and in no event later than two (2) Trading Days after receipt of the Preferred Share Certificate(s)
and at its own expense, issue and mail to such Holder (or its designee) by overnight courier service a new Preferred Share Certificate
or a new Book-Entry (in either case, in accordance with Section 22(d)) representing the number of Preferred Shares not converted. The
Person or Persons entitled to receive the Conversion Shares issuable upon a conversion of Preferred Shares shall be treated for all purposes
as the record holder or holders of such Conversion Shares on the Conversion Date. Notwithstanding the foregoing, if a Holder delivers
a Conversion Notice to the Company prior to the date of issuance of Preferred Shares to such Holder, whereby such Holder elects to convert
such Preferred Shares pursuant to such Conversion Notice, the Share Delivery Deadline with respect to any such Conversion Notice shall
be the later of (x) the date of issuance of such Preferred Shares and (y) the first (1st) Trading Day after the date of such Conversion
Notice. Notwithstanding anything to the contrary contained in this Certificate of Designations or the Registration Rights Agreement,
after the effective date of a Registration Statement (as defined in the Registration Rights Agreement) and prior to a Holder’s
receipt of the notice of a Grace Period (as defined in the Registration Rights Agreement), the Company shall cause the Transfer Agent
to deliver unlegended shares of Common Stock to such Holder (or its designee) in connection with any sale of Registrable Securities (as
defined in the Registration Rights Agreement) with respect to which such Holder has entered into a contract for sale, and delivered a
copy of the prospectus included as part of the particular Registration Statement to the extent applicable, and for which such Holder
has not yet settled.
(ii) Company’s Failure to Timely Convert. If the Company shall fail, for any reason
or for no reason, on or prior to the applicable Share Delivery Deadline, either (I) if the Transfer Agent is not participating in FAST
or the Resale Eligibility Conditions are not satisfied, to issue and deliver to such Holder (or its designee) a certificate for the number
of Conversion Shares to which such Holder is entitled and register such Conversion Shares on the Company’s share register or, if
the Transfer Agent is participating in FAST and the Resale Eligibility Conditions are satisfied, to credit such Holder’s or its
designee’s balance account with DTC for such number of Conversion Shares to which such Holder is entitled upon such Holder’s
conversion of any Conversion Amount (as the case may be) or (II) if the Registration Statement covering the resale of the Conversion
Shares that are the subject of the Conversion Notice (the “Unavailable Conversion Shares”) is not available for the
resale of such Unavailable Conversion Shares and the Company fails to promptly, but in no event later than as required pursuant to the
Registration Rights Agreement (x) notify such Holder and (y) deliver the shares of Common Stock electronically without any restrictive
legend by crediting such aggregate number of shares of Common Stock to which such Holder is entitled pursuant to such conversion to such
Holder’s or its designee’s balance account with DTC through its Deposit/Withdrawal At Custodian system (the event described
in the immediately foregoing clause (II) is hereinafter referred to as a “Notice Failure” and together with the event
described in clause (I) above, a “Conversion Failure”), and if on or after such Share Delivery Deadline such Holder
acquires (in an open market transaction, stock loan or otherwise) shares of Common Stock corresponding to all or any portion of the number
of Conversion Shares issuable upon such conversion that such Holder is entitled to receive from the Company and has not received from
the Company in connection with such Conversion Failure or Notice Failure, as applicable (a “Buy-In”), then, in addition
to all other remedies available to such Holder, the Company shall, within two (2) Business Days after receipt of such Holder’s
request and in such Holder’s discretion, either: (I) pay cash to such Holder in an amount equal to such Holder’s total purchase
price (including brokerage commissions, stock loan costs and other out-of-pocket expenses, if any) for the shares of Common Stock so
acquired (including, without limitation, by any other Person in respect, or on behalf, of such Holder) (the “Buy-In Price”),
at which point the Company’s obligation to so issue and deliver such certificate (and to issue such Conversion Shares) or credit
to the balance account of such Holder or such Holder’s designee, as applicable, with DTC for the number of Conversion Shares to
which such Holder is entitled upon such Holder’s conversion hereunder (as the case may be) (and to issue such Conversion Shares)
shall terminate, or (II) promptly honor its obligation to so issue and deliver to such Holder a certificate or certificates representing
such Conversion Shares or credit the balance account of such Holder or such Holder’s designee, as applicable, with DTC for the
number of Conversion Shares to which such Holder is entitled upon such Holder’s conversion hereunder (as the case may be) and pay
cash to such Holder in an amount equal to the excess (if any) of the Buy-In Price over the product of (x) such number of shares of Common
Stock multiplied by (y) the lowest Closing Sale Price of the Common Stock on any Trading Day during the period commencing on the date
of the applicable Conversion Notice and ending on the date of such issuance and payment under this clause (II) (each, a “Buy-In
Payment Amount”). In addition to the foregoing, if on or prior to the Share Delivery Deadline either (A) the Transfer Agent
is not participating in FAST or the Resale Eligibility Conditions are not satisfied, the Company shall fail to issue and deliver to such
Holder (or its designee) a certificate and register such Conversion Shares on the Company’s share register or, if the Transfer
Agent is participating in the FAST and the Resale Eligibility Conditions are satisfied, the Transfer Agent shall fail to credit the balance
account of such Holder or such Holder’s designee, as applicable, with DTC for the number of Conversion Shares to which such Holder
is entitled upon such Holder’s conversion hereunder or pursuant to the Company’s obligation pursuant to clause (ii) below
or (B) a Notice Failure occurs, and such Holder is a Major Buyer (as defined in the Securities Purchase Agreement), then, in addition
to all other remedies available to such Holder, (X) the Company shall pay in cash to such Holder on each day after the Share Delivery
Deadline that the issuance of such Conversion Shares is not timely effected an amount equal to 1% of the product of (A) the sum of the
number of Conversion Shares not issued to such Holder on or prior to the Share Delivery Deadline and to which such Holder is entitled,
multiplied by (B) any trading price of the Common Stock selected by such Holder in writing as in effect at any time during the period
beginning on the applicable Conversion Date and ending on the applicable Share Delivery Deadline and (Y) such Holder, upon written notice
to the Company, may void its Conversion Notice with respect to, and retain or have returned, as the case may be, all, or any portion,
of such Preferred Shares that has not been converted pursuant to such Conversion Notice; provided that the voiding of a Conversion Notice
shall not affect the Company’s obligations to make any payments which have accrued prior to the date of such notice pursuant to
this Section 4(c)(ii) or otherwise. Nothing herein shall limit a Holder’s right to pursue any other remedies available to it hereunder,
at law or in equity, including, without limitation, a decree of specific performance and/or injunctive relief with respect to the Company’s
failure to timely deliver certificates representing Conversion Shares (or to electronically deliver such Conversion Shares) upon the
conversion of the Preferred Shares as required pursuant to the terms hereof. Notwithstanding anything herein to the contrary, with respect
to any given Notice Failure and/or Conversion Failure, as applicable, this Section 4(c)(ii) shall not apply to a Holder to the extent
the Company has already paid such amounts in full to such Holder with respect to such Notice Failure and/or Conversion Failure, as applicable,
pursuant to the analogous sections of the Securities Purchase Agreement.
(iii) Registration; Book-Entry. At the time of issuance of any Preferred Shares hereunder,
the applicable Holder may, by written request (including by electronic-mail) to the Company, elect to receive such Preferred Shares in
the form of one or more Preferred Share Certificates or in Book-Entry form. The Company (or the Transfer Agent, as custodian for the
Preferred Shares) shall maintain a register (the “Register”) for the recordation of the names and addresses of the
Holders of each Preferred Share and the Stated Value of the Preferred Shares and whether the Preferred Shares are held by such Holder
in Preferred Share Certificates or in Book-Entry form (the “Registered Preferred Shares”). The entries in the Register
shall be conclusive and binding for all purposes absent manifest error. The Company and each Holder of the Preferred Shares shall treat
each Person whose name is recorded in the Register as the owner of a Preferred Share for all purposes (including, without limitation,
the right to receive payments and Dividends hereunder) notwithstanding notice to the contrary. A Registered Preferred Share may be assigned,
transferred or sold only by registration of such assignment or sale on the Register. Upon its receipt of a written request to assign,
transfer or sell one or more Registered Preferred Shares by such Holder thereof, the Company shall record the information contained therein
in the Register and issue one or more new Registered Preferred Shares in the same aggregate Stated Value as the Stated Value of the surrendered
Registered Preferred Shares to the designated assignee or transferee pursuant to Section 22, provided that if the Company does not
so record an assignment, transfer or sale (as the case may be) of such Registered Preferred Shares within two (2) Business Days of such
a request, then the Register shall be automatically deemed updated to reflect such assignment, transfer or sale (as the case may be).
Notwithstanding anything to the contrary set forth in this Section 4, following conversion of any Preferred Shares in accordance
with the terms hereof, the applicable Holder shall not be required to physically surrender such Preferred Shares held in the form of
a Preferred Share Certificate to the Company unless (A) the full or remaining number of Preferred Shares represented by the applicable
Preferred Share Certificate are being converted (in which event such certificate(s) shall be delivered to the Company as contemplated
by this Section 4(c)(iii)) or (B) such Holder has provided the Company with prior written notice (which notice may be included in a Conversion
Notice) requesting reissuance of Preferred Shares upon physical surrender of the applicable Preferred Share Certificate. Each Holder
and the Company shall maintain records showing the Stated Value and Dividends converted and/or paid (as the case may be) and the dates
of such conversions and/or payments (as the case may be) or shall use such other method, reasonably satisfactory to such Holder and the
Company, so as not to require physical surrender of a Preferred Share Certificate upon conversion. If the Company does not update the
Register to record such Stated Value and Dividends converted and/or paid (as the case may be) and the dates of such conversions and/or
payments (as the case may be) within two (2) Business Days of such occurrence, then the Register shall be automatically deemed updated
to reflect such occurrence. In the event of any dispute or discrepancy, the records of the Company establishing the number of Preferred
Shares to which the record holder is entitled shall be controlling and determinative in the absence of manifest error. A Holder and any
transferee or assignee, by acceptance of a certificate, acknowledge and agree that, by reason of the provisions of this paragraph, following
conversion of any Preferred Shares, the number of Preferred Shares represented by such certificate may be less than the number of Preferred
Shares stated on the face thereof. Each Preferred Share Certificate shall bear the following legend:
ANY
TRANSFEREE OR ASSIGNEE OF THIS CERTIFICATE SHOULD CAREFULLY REVIEW THE TERMS OF THE CORPORATION’S CERTIFICATE OF DESIGNATIONS RELATING
TO THE SHARES OF SERIES B CONVERTIBLE PREFERRED STOCK REPRESENTED BY THIS CERTIFICATE, INCLUDING SECTION 4(c)(ii) THEREOF. THE NUMBER
OF SHARES OF SERIES B CONVERTIBLE PREFERRED STOCK REPRESENTED BY THIS CERTIFICATE MAY BE LESS THAN THE NUMBER OF SHARES OF SERIES B CONVERTIBLE
PREFERRED STOCK STATED ON THE FACE HEREOF PURSUANT TO SECTION 4(c)(ii) OF THE CERTIFICATE OF DESIGNATIONS RELATING TO THE SHARES OF SERIES
B CONVERTIBLE PREFERRED STOCK REPRESENTED BY THIS CERTIFICATE.
5. Pro
Rata Conversion; Disputes. In the event that the Company receives a Conversion Notice from more than one Holder for the same Conversion
Date and the Company can convert some, but not all, of such Preferred Shares submitted for conversion, the Company shall convert from
each Holder electing to have Preferred Shares converted on such date a pro rata amount of such Holder’s Preferred Shares submitted
for conversion on such date based on the number of Preferred Shares submitted for conversion on such date by such Holder relative to
the aggregate number of Preferred Shares submitted for conversion on such date. In the event of a dispute as to the number of Conversion
Shares issuable to a Holder in connection with a conversion of Preferred Shares, the Company shall issue to such Holder the number of
Conversion Shares not in dispute and resolve such dispute in accordance with Section 27. If a Conversion Notice delivered to the Company
would result in a breach of Section 5(a) below, and the applicable Holder does not elect in writing to withdraw, in whole, such Conversion
Notice, the Company shall hold such Conversion Notice in abeyance until such time as such Conversion Notice may be satisfied without
violating Section 5(a) below (with such calculations thereunder made as of the date such Conversion Notice was initially delivered to
the Company).
(a) Limitation
on Beneficial Ownership.
(i)
Beneficial Ownership. The Company shall not effect the conversion of any of the Preferred Shares held by a Holder, and such Holder
shall not have the right to convert any of the Preferred Shares held by such Holder pursuant to the terms and conditions of this Certificate
of Designations and any such conversion shall be null and void and treated as if never made, to the extent that after giving effect to
such conversion, such Holder together with the other Attribution Parties collectively would beneficially own in excess of 4.99% (the
“Maximum Percentage”) of the shares of Common Stock outstanding immediately after giving effect to such conversion.
For purposes of the foregoing sentence, the aggregate number of shares of Common Stock beneficially owned by such Holder and the other
Attribution Parties shall include the number of shares of Common Stock held by such Holder and all other Attribution Parties plus
the number of shares of Common Stock issuable upon conversion of the Preferred Shares with respect to which the determination of
such sentence is being made, but shall exclude shares of Common Stock which would be issuable upon (A) conversion of the remaining, nonconverted
Preferred Shares beneficially owned by such Holder or any of the other Attribution Parties and (B) exercise or conversion of the unexercised
or nonconverted portion of any other securities of the Company (including, without limitation, any convertible notes, convertible preferred
stock or warrants, including the Preferred Shares and the Warrants) beneficially owned by such Holder or any other Attribution Party
subject to a limitation on conversion or exercise analogous to the limitation contained in this Section 5(a). For purposes of this Section
5(a), beneficial ownership shall be calculated in accordance with Section 13(d) of the 1934 Act. For the avoidance of doubt, the calculation
of the Maximum Percentage shall take into account the concurrent exercise and/or conversion, as applicable, of the unexercised or unconverted
portion of any other securities of the Company beneficially owned by such Holder and/or any other Attribution Party, as applicable. For
purposes of determining the number of outstanding shares of Common Stock a Holder may acquire upon the conversion of such Preferred Shares
without exceeding the Maximum Percentage, such Holder may rely on the number of outstanding shares of Common Stock as reflected in (x)
the Company’s most recent Annual Report on Form 10-K, Quarterly Report on Form 10-Q, Current Report on Form 8-K or other public
filing with the SEC, as the case may be, (y) a more recent public announcement by the Company or (z) any other written notice by the
Company or the Transfer Agent, if any, setting forth the number of shares of Common Stock outstanding (the “Reported Outstanding
Share Number”). If the Company receives a Conversion Notice from a Holder at a time when the actual number of outstanding shares
of Common Stock is less than the Reported Outstanding Share Number, the Company shall notify such Holder in writing of the number of
shares of Common Stock then outstanding and, to the extent that such Conversion Notice would otherwise cause such Holder’s beneficial
ownership, as determined pursuant to this Section 5(a), to exceed the Maximum Percentage, such Holder must notify the Company of a reduced
number of shares of Common Stock to be purchased pursuant to such Conversion Notice. For any reason at any time, upon the written or
oral request of any Holder, the Company shall within one (1) Business Day confirm orally and in writing or by electronic mail to such
Holder the number of shares of Common Stock then outstanding. In any case, the number of outstanding shares of Common Stock shall be
determined after giving effect to the conversion or exercise of securities of the Company, including such Preferred Shares, by such Holder
and any other Attribution Party since the date as of which the Reported Outstanding Share Number was reported. In the event that the
issuance of shares of Common Stock to a Holder upon conversion of such Preferred Shares results in such Holder and the other Attribution
Parties being deemed to beneficially own, in the aggregate, more than the Maximum Percentage of the number of outstanding shares of Common
Stock (as determined under Section 13(d) of the 1934 Act), the number of shares so issued by which such Holder’s and the other
Attribution Parties’ aggregate beneficial ownership exceeds the Maximum Percentage (the “Excess Shares”) shall
be deemed null and void and shall be cancelled ab initio, and such Holder shall not have the power to vote or to transfer the Excess
Shares. Upon delivery of a written notice to the Company, any Holder may from time to time increase (with such increase not effective
until the sixty-first (61st) day after delivery of such notice) or decrease the Maximum Percentage of such Holder to any other
percentage not in excess of 9.99% as specified in such notice; provided that (i) any such increase in the Maximum Percentage will not
be effective until the sixty-first (61st) day after such notice is delivered to the Company and (ii) any such increase or
decrease will apply only to such Holder and the other Attribution Parties and not to any other Holder that is not an Attribution Party
of such Holder. For purposes of clarity, the shares of Common Stock issuable to a Holder pursuant to the terms of this Certificate of
Designations in excess of the Maximum Percentage shall not be deemed to be beneficially owned by such Holder for any purpose including
for purposes of Section 13(d) or Rule 16a-1(a)(1) of the 1934 Act. No prior inability to convert such Preferred Shares pursuant to this
paragraph shall have any effect on the applicability of the provisions of this paragraph with respect to any subsequent determination
of convertibility. The provisions of this paragraph shall not be construed and implemented in a manner otherwise than in strict conformity
with the terms of this Section 5(a) to the extent necessary to correct this paragraph (or any portion of this paragraph) which may be
defective or inconsistent with the intended beneficial ownership limitation contained in this Section 5(a) or to make changes or supplements
necessary or desirable to properly give effect to such limitation. The limitation contained in this paragraph may not be waived and shall
apply to a successor holder of such Preferred Shares.
6. Principal
Market Regulation. The Company shall not issue any shares of Common Stock upon conversion of any Preferred Shares or otherwise pursuant
to the terms of this Certificate of Designations if the issuance of such shares of Common Stock would exceed the aggregate number of
shares of Common Stock which the Company may issue upon exercise or conversion (as the case may be) of the Series A Convertible Preferred
Stock and Preferred Shares without breaching the Company’s obligations under the rules and regulations the listing rules of the
Principal Market (the maximum number of shares of Common Stock which may be issued without violating such rules and regulations, the
“Exchange Cap”), except that such limitation shall not apply in the event that the Company (A) obtains the approval
of its stockholders as required by the applicable rules and regulations of the Principal Market for issuances of shares of Common Stock
in excess of such amount (the “Stockholder Approval Date”) or (B) obtains a written opinion from outside counsel to
the Company that such approval is not required, which opinion shall be reasonably satisfactory to the Required Holders. Until such approval
or such written opinion is obtained, no Holder shall be issued in the aggregate, upon conversion or exercise (as the case may be) of
any Preferred Shares, shares of Common Stock in an amount greater than the product of (i) the Exchange Cap as of the Initial Issuance
Date multiplied by (ii) the quotient of (1) the aggregate number of Preferred Shares issued to such Holder on the Initial Issuance Date
divided by (2) the aggregate number of shares of Series A Convertible Preferred Stock, Preferred Shares and Parity Stock outstanding
as of the Initial Issuance Date (with respect to each Holder, the “Exchange Cap Allocation”). In the event that any
Holder shall sell or otherwise transfer any of such Holder’s Preferred Shares, the transferee shall be allocated a pro rata portion
of such Holder’s Exchange Cap Allocation with respect to such portion of such Preferred Shares so transferred, and the restrictions
of the prior sentence shall apply to such transferee with respect to the portion of the Exchange Cap Allocation so allocated to such
transferee. Upon conversion in full of a Holder’s Preferred Shares, the difference (if any) between such Holder’s Exchange
Cap Allocation and the number of shares of Common Stock actually issued to such Holder upon such Holder’s conversion in full of
such Preferred Shares shall be allocated, to the respective Exchange Cap Allocations of the remaining holders of Series A Convertible
Preferred Shares and Preferred Shares and Parity Stock on a pro rata basis in proportion to the shares of Common Stock underlying the
shares of preferred stock of the Company then held by each such holder of Series A Convertible Preferred Shares, Preferred Shares and/or
Parity Stock, as applicable.
(a) Right
of Alternate Conversion Upon a Triggering Event.
7. General.
Subject to Section 5(a), at any time after the earlier of a Holder’s receipt of a Triggering Event Notice (as defined below) and
such Holder becoming aware of a Triggering Event (such earlier date, the “Alternate Conversion Right Commencement Date”)
and ending (such ending date, the “Alternate Conversion Right Expiration Date”, and each such period, an “Alternate
Conversion Right Period”) on the twentieth (20th) Trading Day after the later of (x) the date such Triggering Event
is cured and (y) such Holder’s receipt of a Triggering Event Notice that includes (I) a reasonable description of the applicable
Triggering Event, (II) a certification as to whether, in the reasonable opinion of the Company, such Triggering Event is capable of being
cured and, if applicable, a reasonable description of any existing plans of the Company to cure such Triggering Event and (III) a certification
as to the date the Triggering Event occurred and, if cured on or prior to the date of such Triggering Event Notice, the applicable Alternate
Conversion Right Expiration Date, such Holder may, at such Holder’s option, by delivery of a Conversion Notice to the Company (the
date of any such Conversion Notice, each an “Alternate Conversion Date”), convert all, or any number of Preferred
Shares held by such Holder into shares of Common Stock at the Alternate Conversion Price (each, an “Alternate Conversion”).
8. Mechanics
of Alternate Conversion. On any Alternate Conversion Date, a Holder may voluntarily convert any number of Preferred Shares held by
such Holder pursuant to Section 4(c) (with “Alternate Conversion Price” replacing “Conversion Price” for all
purposes hereunder with respect to such Alternate Conversion and with “the applicable Required Premium multiplied by the Conversion
Amount” replacing “Conversion Amount” in clause (x) of the definition of Conversion Rate in Section 4(b) above with
respect to such Alternate Conversion) by designating in the Conversion Notice delivered pursuant to this Section 8 of this Certificate
of Designations that such Holder is electing to use the Alternate Conversion Price for such conversion; provided that in the event of
the Conversion Floor Price Condition, on the applicable Alternate Conversion Date the Stated Value of the remaining Preferred Shares
of such Holder shall automatically increase, pro rata, by the applicable Alternate Conversion Floor Amount or, at the Company’s
option, the Company shall deliver the applicable Alternate Conversion Floor Amount to such applicable Holder on the applicable Alternate
Conversion Date. Notwithstanding anything to the contrary in this Section 8, but subject to Section 5(a), until the Company delivers
to such Holder the shares of Common Stock to which such Holder is entitled pursuant to the applicable Alternate Conversion of such Holder’s
Preferred Shares, such Preferred Shares may be converted by such Holder into shares of Common Stock pursuant to Section 4(c) without
regard to this Section 8. In the event of an Alternate Conversion pursuant to this Section 8 of all, or any portion, of any Preferred
Shares of a Holder, such Holder’s damages would be uncertain and difficult to estimate because of the parties’ inability
to predict future interest rates and the uncertainty of the availability of a suitable substitute investment opportunity for such Holder.
Accordingly, any redemption premium due under this Section 8, together the Alternate Conversion Price used in such Alternate Conversion,
as applicable, is intended by the parties to be, and shall be deemed, a reasonable estimate of, such Holder’s actual loss of its
investment opportunity and not as a penalty.
9. Triggering
Events.
(a) General.
Each of the following events shall constitute a “Triggering Event” and each of the events in clauses 9(a)(x), 9(a)(xi),
and 9(a)(xii), shall constitute a “Bankruptcy Triggering Event”:
(i)
the failure of the applicable Registration Statement (as defined in the Registration Rights Agreement) to be filed with the SEC on or
prior to the date that is ten (10) days after the applicable Filing Deadline (as defined in the Registration Rights Agreement) or the
failure of the applicable Registration Statement to be declared effective by the SEC on or prior to the date that is ten (10) days after
the applicable Effectiveness Deadline (as defined in the Registration Rights Agreement);
(ii)
while the applicable Registration Statement is required to be maintained effective pursuant to the terms of the Registration Rights Agreement,
the effectiveness of the applicable Registration Statement lapses for any reason (including, without limitation, the issuance of a stop
order) or such Registration Statement (or the prospectus contained therein) is unavailable to any holder of Registrable Securities (as
defined in the Registration Rights Agreement) for sale of all of such holder’s Registrable Securities in accordance with the terms
of the Registration Rights Agreement, and such lapse or unavailability continues for a period of seven (7) consecutive days or for more
than an aggregate of fifteen (15) days in any 365-day period (excluding days during an Allowable Grace Period (as defined in the Registration
Rights Agreement));
(iii) the suspension from trading or the failure of the Common Stock to be trading or listed (as
applicable) on an Eligible Market for a period of five (5) consecutive Trading Days or the delisting, removal or withdrawal, as applicable,
of registration of the Common Stock under the 1934 Act with respect to a going-private transaction;
(iv) the Company’s (A) failure to cure a Conversion Failure by delivery of the required number
of shares of Common Stock within five (5) Trading Days after the applicable Conversion Date or exercise date (as the case may be) or
(B) notice, written or oral, to any holder of Preferred Shares, including, without limitation, by way of public announcement or through
any of its agents, at any time, of its intention not to comply, as required, with a request for conversion of any Preferred Shares into
shares of Common Stock that is requested in accordance with the provisions of this Certificate of Designations, other than pursuant to
Section 5(a) hereof;
(v) except to the extent the Company is in compliance with Section 15(b) below, at any time following
the tenth (10th) consecutive day that a Holder’s Authorized Share Allocation (as defined in Section 15(a) below) is less than the
sum of the Required Reserve Amount as of such date of determination and;
(vi)
subject to the provisions of Section 170 of the DGCL, the Board fails to declare any Dividend to be capitalized or paid in accordance
with Section 3;
(vii) the Company’s failure to pay to any Holder any Dividend when required to be paid hereunder
(whether or not declared by the Board) or any other amount when and as due under this Certificate of Designations (including, without
limitation, the Company’s failure to pay any redemption payments or amounts hereunder), the Securities Purchase Agreement or any
other Transaction Document or any other agreement, document, certificate or other instrument delivered in connection with the transactions
contemplated hereby and thereby (in each case, whether or not permitted pursuant to the DGCL), except, in the case of a failure to pay
Dividends when and as due, in each such case only if such failure remains uncured for a period of at least five (5) Trading Days;
(viii) the Company fails to remove any restrictive legend on any certificate or any shares of Common
Stock issued to the applicable Holder upon conversion or exercise (as the case may be) of any Securities (as defined in the Securities
Purchase Agreement) acquired by such Holder under the Securities Purchase Agreement (including this Certificate of Designations) as and
when required by such Securities or the Securities Purchase Agreement, unless otherwise then prohibited by applicable federal securities
laws, and any such failure remains uncured for at least five (5) Trading Days;
(ix) the occurrence of any default under, redemption of or acceleration prior to maturity of at
least an aggregate of $1,000,000 of Indebtedness (as defined in the Securities Purchase Agreement) of the Company or any of its Subsidiaries,
other than with respect to any Preferred Shares;
(x) bankruptcy, insolvency, reorganization or liquidation proceedings or other proceedings for
the relief of debtors shall be instituted by or against the Company or any Subsidiary and, if instituted against the Company or any Subsidiary
by a third party, shall not be dismissed within thirty (30) days of their initiation;
(xi) the commencement by the Company or any Subsidiary of a voluntary case or proceeding under any
applicable federal, state or foreign bankruptcy, insolvency, reorganization or other similar law or of any other case or proceeding to
be adjudicated a bankrupt or insolvent, or the consent by it to the entry of a decree, order, judgment or other similar document in respect
of the Company or any Subsidiary in an involuntary case or proceeding under any applicable federal, state or foreign bankruptcy, insolvency,
reorganization or other similar law or to the commencement of any bankruptcy or insolvency case or proceeding against it, or the filing
by it of a petition or answer or consent seeking reorganization or relief under any applicable federal, state or foreign law, or the
consent by it to the filing of such petition or to the appointment of or taking possession by a custodian, receiver, liquidator, assignee,
trustee, sequestrator or other similar official of the Company or any Subsidiary or of any substantial part of its property, or the making
by it of an assignment for the benefit of creditors, or the execution of a composition of debts, or the occurrence of any other similar
federal, state or foreign proceeding, or the admission by it in writing of its inability to pay its debts generally as they become due,
the taking of corporate action by the Company or any Subsidiary in furtherance of any such action or the taking of any action by any
Person to commence a Uniform Commercial Code foreclosure sale or any other similar action under federal, state or foreign law;
(xii) the entry by a court of (i) a decree, order, judgment or other similar document in respect
of the Company or any Subsidiary of a voluntary or involuntary case or proceeding under any applicable federal, state or foreign bankruptcy,
insolvency, reorganization or other similar law or (ii) a decree, order, judgment or other similar document adjudging the Company or
any Subsidiary as bankrupt or insolvent, or approving as properly filed a petition seeking liquidation, reorganization, arrangement,
adjustment or composition of or in respect of the Company or any Subsidiary under any applicable federal, state or foreign law or (iii)
a decree, order, judgment or other similar document appointing a custodian, receiver, liquidator, assignee, trustee, sequestrator or
other similar official of the Company or any Subsidiary or of any substantial part of its property, or ordering the winding up or liquidation
of its affairs, and the continuance of any such decree, order, judgment or other similar document or any such other decree, order, judgment
or other similar document unstayed and in effect for a period of thirty (30) consecutive days;
(xiii) a final judgment or judgments for the payment of money aggregating in excess of $500,000 are
rendered against the Company and/or any of its Subsidiaries and which judgments are not, within thirty (30) days after the entry thereof,
bonded, discharged, settled or stayed pending appeal, or are not discharged within thirty (30) days after the expiration of such stay;
provided, however, any judgment which is covered by insurance or an indemnity from a credit worthy party shall not be included in calculating
the $500,000 amount set forth above so long as the Company provides each Holder a written statement from such insurer or indemnity provider
(which written statement shall be reasonably satisfactory to each Holder) to the effect that such judgment is covered by insurance or
an indemnity and the Company or such Subsidiary (as the case may be) will receive the proceeds of such insurance or indemnity within
thirty (30) days of the issuance of such judgment;
(xiv) the Company and/or any Subsidiary, individually or in the aggregate, either (i) fails to pay,
when due, or within any applicable grace period, any payment with respect to any Indebtedness in excess of $1,000,000 due to any third
party (other than payments contested by the Company and/or such Subsidiary (as the case may be) in good faith by proper proceedings and
with respect to which adequate reserves have been set aside for the payment thereof in accordance with GAAP) or is otherwise in breach
or violation of any agreement for monies owed or owing in an amount in excess of $1,000,000, which breach or violation permits the other
party thereto to declare a default or otherwise accelerate amounts due thereunder, or (ii) suffer to exist any other circumstance or
event that would, with or without the passage of time or the giving of notice, result in a default or event of default under any agreement
binding the Company or any Subsidiary, which default or event of default would or is likely to have a material adverse effect on the
business, assets, operations (including results thereof), liabilities, properties, condition (including financial condition) or prospects
of the Company or any of its Subsidiaries, individually or in the aggregate;
(xv) other than as specifically set forth in another clause of this Section 9(a), the Company or
any Subsidiary breaches any representation or warranty in any material respect (other than representations or warranties subject to material
adverse effect or materiality, which may not be breached in any respect) or any covenant or other term or condition of any Transaction
Document, except, in the case of a breach of a covenant or other term or condition that is curable, only if such breach remains uncured
for a period of five (5) consecutive Trading Days;
(xvi) a false or inaccurate certification (including a false or inaccurate deemed certification)
by the Company as to whether any Triggering Event has occurred;
(xvii) any Preferred Shares remain outstanding on or after August 14, 2025;
(xviii) any breach or failure in any respect by the Company or any Subsidiary to comply with any provision
of Section 17 of this Certificate of Designations;
(xix) any Change of Control occurs without either (A) the prior written consent of the Required Holders
(as defined in the Securities Purchase Agreement), which consent shall not be unreasonably withheld, conditioned or delayed or (B) a
Series A Holder Consent;
(xx) any Material Adverse Effect (as defined in the Securities Purchase Agreement) occurs; or
(xxi) any provision of any Transaction Document shall at any time for any reason (other than pursuant
to the express terms thereof) cease to be valid and binding on or enforceable against the parties thereto, or the validity or enforceability
thereof shall be contested, directly or indirectly, by the Company or any Subsidiary, or a proceeding shall be commenced by the Company
or any Subsidiary or any Governmental Authority having jurisdiction over any of them, seeking to establish the invalidity or unenforceability
thereof or the Company or any of its Subsidiaries shall deny in writing that it has any liability or obligation purported to be created
under one or more Transaction Documents.
(b) Notice
of a Triggering Event. Upon the occurrence of a Triggering Event with respect to the Preferred Shares, the Company shall within two
(2) Business Days deliver written notice thereof via electronic mail and overnight courier (with next day delivery specified) (a “Triggering
Event Notice”) to each Holder.
(c) Mandatory
Redemption upon Bankruptcy Triggering Event. Notwithstanding anything to the contrary herein, and notwithstanding any conversion
that is then required or in process, upon any Bankruptcy Triggering Event, the Company shall immediately redeem, in cash, each of the
Preferred Shares then outstanding at a redemption price equal to the greater of (i) the product of (A) the Conversion Amount to be redeemed
multiplied by (B) the Required Premium and (ii) the product of (X) the Conversion Rate (calculated using the lowest Alternate Conversion
Price during the period commencing on the 20th Trading Day immediately preceding such public announcement and ending on the date the
Company makes the entire redemption payment pursuant to this Section 9(c)) with respect to the Conversion Amount in effect immediately
following the date of initial public announcement (or public filing of bankruptcy documents, as applicable) of such Bankruptcy Triggering
Event multiplied by (Y) the product of (1) the Required Premium multiplied by (2) the greatest Closing Sale Price of the Common Stock
on any Trading Day during the period commencing on the date immediately preceding such Bankruptcy Triggering Event and ending on the
date the Company makes the entire payment required to be made under this Section 9(c), without the requirement for any notice or demand
or other action by any Holder or any other person or entity, provided that a Holder may, in its sole discretion, waive such right to
receive payment upon a Bankruptcy Triggering Event, in whole or in part, and any such waiver shall not affect any other rights of such
Holder or any other Holder hereunder, including any other rights in respect of such Bankruptcy Triggering Event or any right to conversion
(or Alternate Conversion), as applicable.
10. Rights
Upon Fundamental Transactions.
(a) Assumption.
The Company shall not enter into or be party to a Fundamental Transaction unless the Successor Entity assumes in writing all of the obligations
of the Company under this Certificate of Designations and the other Transaction Documents in accordance with the provisions of this Section
10(a) pursuant to written agreements in form and substance reasonably satisfactory to the Required Holders, including agreements to deliver
to each holder of Preferred Shares in exchange for such Preferred Shares a security of the Successor Entity evidenced by a written instrument
substantially similar in form and substance to this Certificate of Designations, including, without limitation, having a stated value
and dividend rate equal to the stated value and dividend rate of the Preferred Shares held by the Holders and having similar ranking
to the Preferred Shares, and reasonably satisfactory to the Required Holders. Upon the occurrence of any Fundamental Transaction, the
Successor Entity shall succeed to, and be substituted for (so that from and after the date of such Fundamental Transaction, the provisions
of this Certificate of Designations and the other Transaction Documents referring to the “Company” shall refer instead to
the Successor Entity), and may exercise every right and power of the Company and shall assume all of the obligations of the Company under
this Certificate of Designations and the other Transaction Documents with the same effect as if such Successor Entity had been named
as the Company herein and therein. In addition to the foregoing, upon consummation of a Fundamental Transaction, the Successor Entity
shall deliver to each Holder confirmation that there shall be issued upon conversion or redemption of the Preferred Shares at any time
after the consummation of such Fundamental Transaction, in lieu of the shares of Common Stock (or other securities, cash, assets or other
property (except such items still issuable under Sections 11 and 19, which shall continue to be receivable thereafter)) issuable upon
the conversion or redemption of the Preferred Shares prior to such Fundamental Transaction, such shares of the publicly traded common
stock (or their equivalent) of the Successor Entity (including its Parent Entity) which each Holder would have been entitled to receive
upon the happening of such Fundamental Transaction had all the Preferred Shares held by each Holder been converted immediately prior
to such Fundamental Transaction (without regard to any limitations on the conversion of the Preferred Shares contained in this Certificate
of Designations), as adjusted in accordance with the provisions of this Certificate of Designations. Notwithstanding the foregoing, such
Holder may elect, at its sole option, by delivery of written notice to the Company to waive this Section 10(a) to permit the Fundamental
Transaction without the assumption of the Preferred Shares. The provisions of this Section 10 shall apply similarly and equally to successive
Fundamental Transactions and shall be applied without regard to any limitations on the conversion or redemption of the Preferred Shares.
(b) Notice
of a Change of Control; Change of Control Election Notice. No sooner than the earlier of (x) twenty (20) Trading Days prior to the
consummation of a Change of Control or (y) the public announcement of the entry into an agreement with respect to a Change of Control,
nor later than ten (10) Trading Days prior to the consummation of a Change of Control (the “Change of Control Date”),
the Company shall deliver written notice thereof via electronic mail and overnight courier to each Holder (a “Change of Control
Notice”). At any time during the period beginning after a Holder’s receipt of a Change of Control Notice or such Holder
becoming aware of a Change of Control if a Change of Control Notice is not delivered to such Holder in accordance with the immediately
preceding sentence (as applicable) and ending on twenty (20) Trading Days after the later of (A) the date of consummation of such Change
of Control or (B) the date of receipt of such Change of Control Notice or (C) the date of the announcement of such Change of Control,
such Holder may require, by delivering written notice thereof (“Change of Control Election Notice”) to the Company
(which Change of Control Election Notice shall indicate the number of Preferred Shares subject to such election), to have the Company
exchange such Holder’s Preferred Shares designated in such Change of Control Election Notice for consideration equal to the Change
of Control Election Price (as defined below), to be satisfied at the Company’s election (such election to pay in cash or by delivery
of the Rights (as defined below), a “Consideration Election”), in either (I) rights (with a beneficial ownership limitation
in the form of Section 5(a) hereof, mutatis mutandis) (collectively, the “Rights”), convertible in whole, or
in part, at any time, without the requirement to pay any additional consideration, at the option of the Required Holders, into such Corporate
Event Consideration (as defined below) applicable to such Change of Control equal in value to the Change of Control Election Price (as
determined with the fair market value of the aggregate number of Successor Shares (as defined below) issuable upon conversion of the
Rights to be determined in increments of 10% (or such greater percentage as the applicable Holder may notify the Company from time to
time) of the portion of the Change of Control Election Price attributable to such Successor Shares (the “Successor Share Value
Increment”), with the aggregate number of Successor Shares issuable upon exercise of the Rights with respect to the first Successor
Share Value Increment determined based on 70% of the VWAP of the Successor Shares on the date the Rights are issued and on each of the
nine (9) subsequent Trading Days, in each case, the aggregate number of additional Successor Shares issuable upon exercise of the Rights
shall be determined based upon a Successor Share Value Increment at 70% of the VWAP of the Successor Shares in effect for such corresponding
Trading Day (such ten (10) Trading Day period commencing on, and including, the date the Rights are issued, the “Rights Measuring
Period”)), or (II) in cash; provided, that the Company shall not consummate a Change of Control if the Corporate Event Consideration
includes capital stock or other equity interest (the “Successor Shares”) either in an entity that is not listed on
an Eligible Market or an entity in which the daily share volume for the applicable Successor Shares for each of the twenty (20) Trading
Days prior to the date of consummation of such Change of Control is less than the aggregate number of Successor Shares issuable to all
Holders upon conversion in full of the applicable Rights (without regard to any limitations on conversion therein, assuming the exercise
in full of the Rights on the date of issuance of the Rights and assuming the VWAP of the Successor Shares for each Trading Day in the
Rights Measuring Period is the VWAP on the Trading Day ended immediately prior to the time of consummation of the Change of Control).
The Company shall give each Holder written notice of each Consideration Election at least twenty (20) Trading Days prior to the time
of consummation of such Change of Control. Payment of such amounts or delivery of the Rights, as applicable, shall be made by the Company
(or at the Company’s direction) to each Holder on the later of (x) the second (2nd) Trading Day after the date of such request
and (y) the date of consummation of such Change of Control (or, with respect to any Right, if applicable, such later time that holders
of shares of Common Stock are initially entitled to receive Corporate Event Consideration with respect to the shares of Common Stock
of such holder). Any Corporate Event Consideration included in the Rights, if any, pursuant to this Section 10(b) is pari passu
with the Corporate Event Consideration to be paid to holders of shares of Common Stock and the Company shall not permit a payment of
any Corporate Event Consideration to the holders of shares of Common Stock without on or prior to such time delivering the Right to the
Holders in accordance herewith. Cash payments, if any, required by this Section 10(b) shall have priority to payments to all other stockholders
of the Company in connection with such Change of Control. Notwithstanding anything to the contrary in this Section 10(b), but subject
to Section 5(a), until the applicable Change of Control Election Price is paid in full to the applicable Holder in cash or Corporate
Event Consideration in accordance herewith, the Preferred Shares submitted by such Holder for exchange or payment, as applicable, under
this Section 10(b) may be converted, in whole or in part, by such Holder into Common Stock pursuant to Section 4 or in the event the
Conversion Date is after the consummation of such Change of Control, stock or equity interests of the Successor Entity substantially
equivalent to the Company’s shares of Common Stock pursuant to Section 10(a). In the event of the Company’s repayment or
exchange, as applicable, of any of the Preferred Shares under this Section 10(b), such Holder’s damages would be uncertain and
difficult to estimate because of the parties’ inability to predict future interest rates and the uncertainty of the availability
of a suitable substitute investment opportunity for a Holder. Accordingly, any Required Premium due under this Section 10(b) is intended
by the parties to be, and shall be deemed, a reasonable estimate of such Holder’s actual loss of its investment opportunity and
not as a penalty. Notwithstanding anything herein to the contrary, in connection with any redemption hereunder at a time a Holder is
entitled to receive a cash payment under any of the other Transaction Documents, at the option of such Holder delivered in writing to
the Company, the applicable redemption price hereunder shall be increased by the amount of such cash payment owed to such Holder under
such other Transaction Document and, upon payment in full or conversion in accordance herewith, shall satisfy the Company’s payment
obligation under such other Transaction Document.
11. Rights
Upon Issuance of Purchase Rights and Other Corporate Events.
(a) Purchase
Rights. In addition to any adjustments pursuant to Section 12 and Section 19 below, if at any time the Company grants, issues or
sells any Options, Convertible Securities or rights to purchase stock, warrants, securities or other property pro rata to all or substantially
all of the record holders of any class of Common Stock (the “Purchase Rights”), then each Holder will be entitled
to acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase Rights which such Holder could have acquired if
such Holder had held the number of shares of Common Stock acquirable upon complete conversion of all the Preferred Shares (without taking
into account any limitations or restrictions on the convertibility of the Preferred Shares and assuming for such purpose that all the
Preferred Shares were converted at the Alternate Conversion Price as of the applicable record date) held by such Holder immediately prior
to the date on which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date
as of which the record holders of shares of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights; provided,
however, to the extent that such Holder’s right to participate in any such Purchase Right would result in such Holder and the other
Attribution Parties exceeding the Maximum Percentage, then such Holder shall not be entitled to participate in such Purchase Right to
such extent of the Maximum Percentage (and shall not be entitled to beneficial ownership of such shares of Common Stock as a result of
such Purchase Right (and beneficial ownership) to such extent of any such excess) and such Purchase Right to such extent shall be held
in abeyance (and, if such Purchase Right has an expiration date, maturity date or other similar provision, such term shall be extended
by such number of days held in abeyance, if applicable) for the benefit of such Holder until such time or times, if ever, as its right
thereto would not result in such Holder and the other Attribution Parties exceeding the Maximum Percentage, at which time or times such
Holder shall be granted such right (and any Purchase Right granted, issued or sold on such initial Purchase Right or on any subsequent
Purchase Right held similarly in abeyance (and, if such Purchase Right has an expiration date, maturity date or other similar provision,
such term shall be extended by such number of days held in abeyance, if applicable)) to the same extent as if there had been no such
limitation.
(b) Other
Corporate Events. In addition to and not in substitution for any other rights hereunder, prior to the consummation of any Fundamental
Transaction pursuant to which holders of shares of Common Stock are entitled to receive securities or other assets with respect to or
in exchange for shares of Common Stock (a “Corporate Event”), the Company shall make appropriate provision to ensure
that each Holder will thereafter have the right, at such Holder’s option, to receive upon a conversion of all the Preferred Shares
held by such Holder (i) such securities or other assets (the “Corporate Event Consideration”) to which such Holder
would have been entitled with respect to such shares of Common Stock had such shares of Common Stock been held by such Holder upon the
consummation of such Corporate Event (without taking into account any limitations or restrictions on the convertibility of the Preferred
Shares set forth in this Certificate of Designations) or (ii) in lieu of the shares of Common Stock otherwise receivable upon such conversion,
such securities or other assets received by the holders of shares of Common Stock in connection with the consummation of such Corporate
Event in such amounts as such Holder would have been entitled to receive had the Preferred Shares held by such Holder initially been
issued with conversion rights for the form of such consideration (as opposed to shares of Common Stock) at a conversion rate for such
consideration commensurate with the Conversion Rate of an Alternate Conversion. Provision made pursuant the preceding sentence shall
be in a form and substance reasonably satisfactory to the Required Holders. The provisions of this Section 11 shall apply similarly and
equally to successive Corporate Events and shall be applied without regard to any limitations on the conversion or redemption of the
Preferred Shares set forth in this Certificate of Designations.
12. Rights
Upon Issuance of Other Securities.
(a) Adjustment
of Conversion Price upon Issuance of Common Stock. If and whenever on or after the Subscription Date the Company grants, issues or
sells (or enters into any agreement to grant, issue or sell), or in accordance with this Section 12(a) is deemed to have granted, issued
or sold, any shares of Common Stock (including the granting, issuance or sale of shares of Common Stock owned or held by or for the account
of the Company, but excluding any Excluded Securities granted, issued or sold or deemed to have been granted, issued or sold) for a consideration
per share (the “New Issuance Price”) less than a price equal to the Conversion Price in effect immediately prior to
such granting, issuance or sale or deemed granting, issuance or sale (such Conversion Price then in effect is referred to herein as the
“Applicable Price”) (the foregoing a “Dilutive Issuance”), then, immediately after such Dilutive
Issuance, the Conversion Price then in effect shall be reduced to an amount equal to the New Issuance Price. For all purposes of the
foregoing (including, without limitation, determining the adjusted Conversion Price and the New Issuance Price under this Section 12(a)),
the following shall be applicable:
(b) Issuance
of Options. If the Company in any manner grants, issues or sells (or enters into any agreement to grant, issue or sell) any Options
and the lowest price per share for which one share of Common Stock is at any time issuable upon the exercise of any such Option or upon
conversion, exercise or exchange of any Convertible Securities issuable upon exercise of any such Option or otherwise pursuant to the
terms thereof is less than the Applicable Price, then such share of Common Stock shall be deemed to be outstanding and to have been issued
and sold by the Company at the time of the granting, issuance or sale of such Option for such price per share. For purposes of this Section
12(b), the “lowest price per share for which one share of Common Stock is at any time issuable upon the exercise of any such Option
or upon conversion, exercise or exchange of any Convertible Securities issuable upon exercise of any such Option or otherwise pursuant
to the terms thereof” shall be equal to (1) the lower of (x) the sum of the lowest amounts of consideration (if any) received or
receivable by the Company with respect to any one share of Common Stock upon the granting, issuance or sale of such Option, upon exercise
of such Option and upon conversion, exercise or exchange of any Convertible Security issuable upon exercise of such Option or otherwise
pursuant to the terms thereof and (y) the lowest exercise price set forth in such Option for which one share of Common Stock is issuable
(or may become issuable assuming all possible market conditions) upon the exercise of any such Options or upon conversion, exercise or
exchange of any Convertible Securities issuable upon exercise of any such Option or otherwise pursuant to the terms thereof, minus (2)
the sum of all amounts paid or payable to the holder of such Option (or any other Person) with respect to any one share of Common Stock
upon the granting, issuance or sale of such Option, upon exercise of such Option and upon conversion, exercise or exchange of any Convertible
Security issuable upon exercise of such Option or otherwise pursuant to the terms thereof plus the value of any other consideration (including,
without limitation, consideration consisting of cash, debt forgiveness, assets or any other property) received or receivable by, or benefit
conferred on, the holder of such Option (or any other Person). Except as contemplated below, no further adjustment of the Conversion
Price shall be made upon the actual issuance of such share of Common Stock or of such Convertible Securities upon the exercise of such
Options or otherwise pursuant to the terms thereof or upon the actual issuance of such shares of Common Stock upon conversion, exercise
or exchange of such Convertible Securities.
(c) Issuance
of Convertible Securities. If the Company in any manner issues or sells (or enters into any agreement to issue or sell) any Convertible
Securities and the lowest price per share for which one share of Common Stock is at any time issuable upon the conversion, exercise or
exchange thereof or otherwise pursuant to the terms thereof is less than the Applicable Price, then such share of Common Stock shall
be deemed to be outstanding and to have been issued and sold by the Company at the time of the issuance or sale (or the time of execution
of such agreement to issue or sell, as applicable) of such Convertible Securities for such price per share. For the purposes of this
Section 12(c), the “lowest price per share for which one share of Common Stock is at any time issuable upon the conversion, exercise
or exchange thereof or otherwise pursuant to the terms thereof” shall be equal to (1) the lower of (x) the sum of the lowest amounts
of consideration (if any) received or receivable by the Company with respect to one share of Common Stock upon the issuance or sale (or
pursuant to the agreement to issue or sell, as applicable) of the Convertible Security and upon conversion, exercise or exchange of such
Convertible Security or otherwise pursuant to the terms thereof and (y) the lowest conversion price set forth in such Convertible Security
for which one share of Common Stock is issuable (or may become issuable assuming all possible market conditions) upon conversion, exercise
or exchange thereof or otherwise pursuant to the terms thereof minus (2) the sum of all amounts paid or payable to the holder of such
Convertible Security (or any other Person) with respect to any one share of Common Stock upon the issuance or sale (or the agreement
to issue or sell, as applicable) of such Convertible Security plus the value of any other consideration received or receivable (including,
without limitation, any consideration consisting of cash, debt forgiveness, assets or other property) by, or benefit conferred on, the
holder of such Convertible Security (or any other Person). Except as contemplated below, no further adjustment of the Conversion Price
shall be made upon the actual issuance of such shares of Common Stock upon conversion, exercise or exchange of such Convertible Securities
or otherwise pursuant to the terms thereof, and if any such issuance or sale of such Convertible Securities is made upon exercise of
any Options for which adjustment of the Conversion Price has been or is to be made pursuant to other provisions of this Section 12(c),
except as contemplated below, no further adjustment of the Conversion Price shall be made by reason of such issuance or sale.
(d) Change
in Option Price or Rate of Conversion. If the purchase or exercise price provided for in any Options, the additional consideration,
if any, payable upon the issue, conversion, exercise or exchange of any Convertible Securities, or the rate at which any Convertible
Securities are convertible into or exercisable or exchangeable for shares of Common Stock increases or decreases at any time (other than
proportional changes in conversion or exercise prices, as applicable, in connection with an event referred to in Section 12(g) below),
the Conversion Price in effect at the time of such increase or decrease shall be adjusted to the Conversion Price which would have been
in effect at such time had such Options or Convertible Securities provided for such increased or decreased purchase price, additional
consideration or increased or decreased conversion rate (as the case may be) at the time initially granted, issued or sold. For purposes
of this Section 12(d), if the terms of any Option or Convertible Security (including, without limitation, any Option or Convertible Security
that was outstanding as of the Subscription Date) are increased or decreased in the manner described in the immediately preceding sentence,
then such Option or Convertible Security and the shares of Common Stock deemed issuable upon exercise, conversion or exchange thereof
shall be deemed to have been issued as of the date of such increase or decrease. No adjustment pursuant to this Section 12(d) shall be
made if such adjustment would result in an increase of the Conversion Price then in effect.
(e) Calculation
of Consideration Received. If any Option and/or Convertible Security and/or Adjustment Right is issued in connection with the issuance
or sale or deemed issuance or sale of any other securities of the Company (as determined by the Required Holder, the “Primary
Security”, and such Option and/or Convertible Security and/or Adjustment Right, the “Secondary Securities”),
together comprising one integrated transaction (or one or more transactions if such issuances or sales or deemed issuances or sales of
securities of the Company either (A) have at least one investor or purchaser in common, (B) are consummated in reasonable proximity to
each other and/or (C) are consummated under the same plan of financing), the aggregate consideration per share of Common Stock with respect
to such Primary Security shall be deemed to be equal to the difference of (x) the lowest price per share for which one share of Common
Stock was issued (or was deemed to be issued pursuant to Section 12(b) or 12(c) above, as applicable) in such integrated transaction
solely with respect to such Primary Security, minus (y) with respect to such Secondary Securities, the sum of (I) the Black Scholes Consideration
Value of each such Option, if any, (II) the fair market value (as determined by the Required Holder in good faith) or the Black Scholes
Consideration Value, as applicable, of such Adjustment Right, if any, and (III) the fair market value (as determined by the Required
Holder) of such Convertible Security, if any, in each case, as determined on a per share basis in accordance with this Section 12(e).
If any shares of Common Stock, Options or Convertible Securities are issued or sold or deemed to have been issued or sold for cash, the
consideration received therefor (for the purpose of determining the consideration paid for such Common Stock, Option or Convertible Security,
but not for the purpose of the calculation of the Black Scholes Consideration Value) will be deemed to be the net amount of consideration
received by the Company therefor. If any shares of Common Stock, Options or Convertible Securities are issued or sold for a consideration
other than cash, the amount of such consideration received by the Company (for the purpose of determining the consideration paid for
such Common Stock, Option or Convertible Security, but not for the purpose of the calculation of the Black Scholes Consideration Value)
will be the fair value of such consideration, except where such consideration consists of publicly traded securities, in which case the
amount of consideration received by the Company for such securities will be the arithmetic average of the VWAPs of such security for
each of the five (5) Trading Days immediately preceding the date of receipt. If any shares of Common Stock, Options or Convertible Securities
are issued to the owners of the non-surviving entity in connection with any merger in which the Company is the surviving entity, the
amount of consideration therefor (for the purpose of determining the consideration paid for such Common Stock, Option or Convertible
Security, but not for the purpose of the calculation of the Black Scholes Consideration Value) will be deemed to be the fair value of
such portion of the net assets and business of the non-surviving entity as is attributable to such shares of Common Stock, Options or
Convertible Securities (as the case may be). The fair value of any consideration other than cash or publicly traded securities will be
determined jointly by the Company and the Required Holder. If such parties are unable to reach agreement within ten (10) days after the
occurrence of an event requiring valuation (the “Valuation Event”), the fair value of such consideration will be determined
within five (5) Trading Days after the tenth (10th) day following such Valuation Event by an independent, reputable appraiser
jointly selected by the Company and the Required Holder. The determination of such appraiser shall be final and binding upon all parties
absent manifest error and the fees and expenses of such appraiser shall be borne by the Company.
(f) Record
Date. If the Company takes a record of the holders of shares of Common Stock for the purpose of entitling them (A) to receive a
dividend or other distribution payable in shares of Common Stock, Options or in Convertible Securities or (B) to subscribe for or
purchase shares of Common Stock, Options or Convertible Securities, then such record date will be deemed to be the date of the
issuance or sale of the shares of Common Stock deemed to have been issued or sold upon the declaration of such dividend or the
making of such other distribution or the date of the granting of such right of subscription or purchase (as the case may
be).
(g) Adjustment
of Conversion Price upon Subdivision or Combination of Common Stock. Without limiting any provision of Section 11 or Section 19,
if the Company at any time on or after the Subscription Date subdivides (by any stock split, stock dividend, stock combination, recapitalization
or other similar transaction) one or more classes of its outstanding shares of Common Stock into a greater number of shares, the Conversion
Price in effect immediately prior to such subdivision will be proportionately reduced. Without limiting any provision of Section 11 or
Section 19, if the Company at any time on or after the Subscription Date combines (by any stock split, stock dividend, stock combination,
recapitalization or other similar transaction) one or more classes of its outstanding shares of Common Stock into a smaller number of
shares, the Conversion Price in effect immediately prior to such combination will be proportionately increased. Any adjustment pursuant
to this Section 12(g) shall become effective immediately after the effective date of such subdivision or combination. If any event requiring
an adjustment under this Section 12(g) occurs during the period that a Conversion Price is calculated hereunder, then the calculation
of such Conversion Price shall be adjusted appropriately to reflect such event.
(h) Holder’s
Right of Adjusted Conversion Price. In addition to and not in limitation of the other provisions of this Section 12(h), if
the Company in any manner issues or sells or enters into any agreement to issue or sell, any Common Stock, Options or Convertible
Securities (other than a Permitted Equity Line (as defined in the Securities Purchase Agreement)) (any such securities, “Variable
Price Securities”) after the Subscription Date that are issuable pursuant to such agreement or convertible into or exchangeable
or exercisable for shares of Common Stock at a price which varies or may vary with the market price of the shares of Common Stock, including
by way of one or more reset(s) to a fixed price, but exclusive of such formulations reflecting share splits, share combinations, and
share dividends (each of the formulations for such variable price being herein referred to as, the “Variable Price”),
the Company shall provide written notice thereof via electronic mail and overnight courier to each Holder on the date of such agreement
and/or the issuance of such shares of Common Stock, Convertible Securities or Options, as applicable. From and after the date the Company
enters into such agreement or issues any such Variable Price Securities, each Holder shall have the right, but not the obligation, in
its sole discretion to substitute the Variable Price for the Conversion Price upon conversion of the Preferred Shares by designating
in the Conversion Notice delivered upon any conversion of Preferred Shares that solely for purposes of such conversion such Holder is
relying on the Variable Price rather than the Conversion Price then in effect. A Holder’s election to rely on a Variable Price
for a particular conversion of Preferred Shares shall not obligate such Holder to rely on a Variable Price for any future conversions
of Preferred Shares.
(i) Calculations.
All calculations under this Section 12 shall be made by rounding to the nearest cent or the nearest 1/100th of a share, as
applicable. The number of shares of Common Stock outstanding at any given time shall not include shares owned or held by or for the account
of the Company, and the disposition of any such shares shall be considered an issue or sale of Common Stock.
(j) Voluntary
Adjustment by Company. Subject to the rules and regulations of the Principal Market, the Company may at any time any Preferred Shares
remain outstanding, with the prior written consent of the Required Holder, reduce the then current Conversion Price to any amount and
for any period of time deemed appropriate by the Board.
(k) Adjustments.
If on any of (i) the Applicable Date, (ii) the ninetieth (90th) calendar day after the Applicable Date or (iii) the one hundred
and eightieth (180th) calendar day after the Applicable Date, as applicable, (each, an “Adjustment Date”),
the Conversion Price then in effect is greater than the greater of (A) $1.00 (as adjusted for stock splits, stock dividends, stock combinations,
recapitalizations and similar events), and (B) the Market Price then in effect (the “Adjustment Price”), on the Adjustment
Date the Conversion Price shall automatically lower to the Adjustment Price.
(l) Exchange
Right. Notwithstanding anything herein to the contrary, if the Company or any of its Subsidiaries consummates any Subsequent Placement
(other than with respect to Excluded Securities (as defined in the Securities Purchase Agreement)), and a Holder elects in writing to
the Company to participate in such Subsequent Placement, each such Holder may, at the option of such Holder as elected in writing to
the Company, exchange all, or any part, of the Preferred Shares of such Holder into the securities in such Subsequent Placement (with
the aggregate amount of such securities to be issued in such exchange equal to such aggregate amount of such securities with a purchase
price valued at 120% of the Conversion Amount of the Preferred Shares delivered by such Holder in exchange therefor).
13. Redemption
at the Company’s Election. At any time, the Company shall have the right to redeem all, but not less than all, of the Preferred
Shares then outstanding (the “Company Optional Redemption Amount”) on the Company Optional Redemption Date (each as
defined below) (a “Company Optional Redemption”). The Preferred Shares subject to redemption pursuant to this Section
13 shall be redeemed by the Company in cash at a price (the “Company Optional Redemption Price”) equal to 120% of
the greater of (i) the Conversion Amount being redeemed as of the Company Optional Redemption Date and (ii) the product of (1) the Conversion
Rate with respect to the Conversion Amount being redeemed as of the Company Optional Redemption Date multiplied by (2) the greatest Closing
Sale Price of the Common Stock on any Trading Day during the period commencing on the date immediately preceding such Company Optional
Redemption Notice Date and ending on the Trading Day immediately prior to the date the Company makes the entire payment required to be
made under this Section 13. The Company may exercise its right to require redemption under this Section 13 by delivering a written notice
thereof by electronic mail and overnight courier to all, but not less than all, of the Holders (the “Company Optional Redemption
Notice” and the date all of the Holders received such notice is referred to as the “Company Optional Redemption Notice
Date”). Such Company Optional Redemption Notice shall be irrevocable; provided that the Company Optional Redemption Notice
may be conditioned upon the consummation of a refinancing transaction or a Going Private Transaction. The Company Optional Redemption
Notice shall (x) state the date on which the Company Optional Redemption shall occur (the “Company Optional Redemption Date”)
which date shall not be less than ten (10) Trading Days nor more than twenty (20) Trading Days following the Company Optional Redemption
Notice Date, and (y) state the aggregate Conversion Amount of the Preferred Shares which is being redeemed in such Company Optional Redemption
from such Holder and all of the other Holders of the Preferred Shares pursuant to this Section 13 on the Company Optional Redemption
Date. The Company shall deliver the applicable Company Optional Redemption Price to each Holder in cash on the applicable Company Optional
Redemption Date. Notwithstanding anything herein to the contrary, at any time prior to the date the Company Optional Redemption Price
is paid, in full, the Company Optional Redemption Amount may be converted, in whole or in part, by any Holder into shares of Common Stock
pursuant to Section 4. All Conversion Amounts converted by a Holder after the Company Optional Redemption Notice Date shall reduce the
Company Optional Redemption Amount of the Preferred Shares of such Holder required to be redeemed on the Company Optional Redemption
Date. In the event of the Company’s redemption of any of the Preferred Shares under this Section 13, a Holder’s damages would
be uncertain and difficult to estimate because of the parties’ inability to predict future interest rates and the uncertainty of
the availability of a suitable substitute investment opportunity for such Holder. Accordingly, any redemption premium due under this
Section 13 is intended by the parties to be, and shall be deemed, a reasonable estimate of such Holder’s actual loss of its investment
opportunity and not as a penalty. For the avoidance of doubt, the Company shall have no right to effect a Company Optional Redemption
if any Triggering Event has occurred and continuing, but any Triggering Event shall have no effect upon any Holder’s right to convert
Preferred Shares in its discretion. Notwithstanding the foregoing, with respect to a Going Private Transaction, the Company may effect
a Company Optional Redemption under this Section 13, but with “Change of Control Election Price” replacing “Company
Optional Redemption Price” for all purposes in this Section 13 in connection therewith.
14. Noncircumvention.
The Company hereby covenants and agrees that the Company will not, by amendment of its Certificate of Incorporation, bylaws or through
any reorganization, transfer of assets, consolidation, merger, scheme of arrangement, dissolution, issue or sale of securities, or any
other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Certificate of Designations,
and will at all times in good faith carry out all the provisions of this Certificate of Designations and take all action as may be required
to protect the rights of the Holders hereunder. Without limiting the generality of the foregoing or any other provision of this Certificate
of Designations or the other Transaction Documents, the Company (a) shall not increase the par value of any shares of Common Stock receivable
upon the conversion of any Preferred Shares above the Conversion Price then in effect, (b) shall take all such actions as may be necessary
or appropriate in order that the Company may validly and legally issue fully paid and non-assessable shares of Common Stock upon the
conversion of Preferred Shares and (c) shall, so long as any Preferred Shares are outstanding, take all action necessary to reserve and
keep available out of its authorized and unissued shares of Common Stock, solely for the purpose of effecting the conversion of the Preferred
Shares, the maximum number of shares of Common Stock as shall from time to time be necessary to effect the conversion of the Preferred
Shares then outstanding (without regard to any limitations on conversion contained herein). Notwithstanding anything herein to the contrary,
if after the sixty (60) calendar day anniversary of the Initial Issuance Date, each Holder is not permitted to convert such Holder’s
Preferred Shares in full for any reason (other than pursuant to restrictions set forth in Section 5(a) hereof), the Company shall use
its best efforts to promptly remedy such failure, including, without limitation, obtaining such consents or approvals as necessary to
effect such conversion into shares of Common Stock.
15. Authorized
Shares.
(a) Reservation.
So long as any Preferred Shares remain outstanding, the Company shall at all times reserve at least 150% of the number of shares of Common
Stock as shall from time to time be necessary to effect the conversion, including without limitation, Alternate Conversions, of all of
the Preferred Shares then outstanding at the Alternate Conversion Price then in effect (without regard to any limitations on conversions)
(the “Required Reserve Amount”). The Required Reserve Amount (including, without limitation, each increase in the
number of shares so reserved) shall be allocated pro rata among the Holders based on the number of the Preferred Shares held by each
Holder on the Initial Issuance Date or increase in the number of reserved shares, as the case may be (the “Authorized Share
Allocation”). In the event that a Holder shall sell or otherwise transfer any of such Holder’s Preferred Shares, each
transferee shall be allocated a pro rata portion of such Holder’s Authorized Share Allocation. Any shares of Common Stock reserved
and allocated to any Person which ceases to hold any Preferred Shares shall be allocated to the remaining Holders of Preferred Shares,
pro rata based on the number of the Preferred Shares then held by the Holders. Notwithstanding the foregoing, a Holder may allocate its
Authorized Share Allocation to any other of the securities of the Company held by such Holder (or any of its designees) by delivery of
a written notice to the Company.
(b) Insufficient
Authorized Shares. If, notwithstanding Section 15 (a) and not in limitation thereof, at any time while any of the Preferred Shares
remain outstanding the Company does not have a sufficient number of authorized and unreserved shares of Common Stock to satisfy its obligation
to reserve for issuance upon conversion of the Preferred Shares at least a number of shares of Common Stock equal to the Required Reserve
Amount (an “Authorized Share Failure”), then the Company shall immediately take all action necessary to increase the
Company’s authorized shares of Common Stock to an amount sufficient to allow the Company to reserve the Required Reserve Amount
for the Preferred Shares then outstanding (or deemed outstanding pursuant to Section 15(a) above). Without limiting the generality of
the foregoing sentence, as soon as practicable after the date of the occurrence of an Authorized Share Failure, but in no event later
than sixty (60) days after the occurrence of such Authorized Share Failure, the Company shall hold a meeting of its stockholders for
the approval of an increase in the number of authorized shares of Common Stock. In connection with such meeting, the Company shall provide
each stockholder with a proxy statement and shall use its best efforts to solicit its stockholders’ approval of such increase in
authorized shares of Common Stock and to cause its board of directors to recommend to the stockholders that they approve such proposal
(or, if a majority of the voting power then in effect of the capital stock of the Company consents to such increase, in lieu of such
proxy statement, deliver to the stockholders of the Company an information statement that has been filed with (and either approved by
or not subject to comments from) the SEC with respect thereto). Notwithstanding the foregoing, if at any such time of an Authorized Share
Failure, the Company is able to obtain the written consent of a majority of the shares of its issued and outstanding shares of Common
Stock to approve the increase in the number of authorized shares of Common Stock, the Company may satisfy this obligation by obtaining
such consent and submitting for filing with the SEC an Information Statement on Schedule 14C. In the event that the Company is prohibited
from issuing shares of Common Stock to a Holder upon any conversion due to the failure by the Company to have sufficient shares of Common
Stock available out of the authorized but unissued shares of Common Stock (such unavailable number of shares of Common Stock, the “Authorized
Failure Shares”), in lieu of delivering such Authorized Failure Shares to such Holder, the Company shall pay cash in exchange
for the redemption of such portion of the Conversion Amount of the Preferred Shares convertible into such Authorized Failure Shares at
a price equal to the sum of (i) the product of (x) such number of Authorized Failure Shares and (y) the greatest Closing Sale Price of
the Common Stock on any Trading Day during the period commencing on the date such Holder delivers the applicable Conversion Notice with
respect to such Authorized Failure Shares to the Company and ending on the date of such issuance and payment under this Section 15(b);
and (ii) to the extent such Holder purchases (in an open market transaction or otherwise) shares of Common Stock to deliver in satisfaction
of a sale by such Holder of Authorized Failure Shares, any brokerage commissions and other out-of-pocket expenses, if any, of such Holder
incurred in connection therewith. Nothing contained in Section 15(a) or this Section 15(b) shall limit any obligations of the Company
under any provision of the Securities Purchase Agreement or Registration Rights Agreement.
16. Voting
Rights. The holders of the Preferred Shares shall have no voting power and no right to vote on any matter at any time, either as
a separate series or class or together with any other series or class of share of capital stock, and shall not be entitled to call a
meeting of such holders for any purpose nor shall they be entitled to participate in any meeting of the holders of Common Stock, except
as provided in this Section 16 and Section 20 or as otherwise required by the DGCL. To the extent that under the DGCL the vote of the
holders of the Preferred Shares, voting separately as a class or series, as applicable, is required to authorize a given action of the
Company, the affirmative vote or consent of the Required Holders of the Preferred Shares, voting together in the aggregate and not in
separate series unless required under the DGCL, represented at a duly held meeting at which a quorum is presented or by written consent
of the Required Holders (except as otherwise may be required under the DGCL), voting together in the aggregate and not in separate series
unless required under the DGCL, shall constitute the approval of such action by both the class or the series, as applicable. Holders
of the Preferred Shares shall be entitled to written notice of all stockholder meetings or written consents (and copies of proxy materials
and other information sent to stockholders) with respect to which they would be entitled to vote, which notice would be provided pursuant
to the Company’s bylaws (the “Bylaws”) and the DGCL.
17. Covenants.
(a) Restriction
on Redemption and Cash Dividends. The Company shall not, and the Company shall cause each of its Subsidiaries to not, directly or
indirectly, redeem, repurchase or declare or pay any cash dividend or distribution on any of its capital stock (other than as required
by this Certificate of Designations). Notwithstanding the foregoing, any waiver or amendment of the Section 17(a) of the Series A Certificate
of Designations by the requisite Series A Investors (as defined in the Securities Purchase Agreement) shall be deemed to also apply to
this Section 17(a).
(b) Restriction
on Transfer of Assets. The Company shall not, and the Company shall cause each of its Subsidiaries to not, directly or indirectly,
sell, lease, license, assign, transfer, spin-off, split-off, close, convey or otherwise dispose of any assets or rights of the Company
or any Subsidiary owned or hereafter acquired whether in a single transaction or a series of related transactions, other than (i) sales,
leases, licenses, assignments, transfers, conveyances and other dispositions (“Dispositions”) of such assets or rights
by the Company and its Subsidiaries in the ordinary course of business consistent with its past practice, (ii) sales of inventory and
product in the ordinary course of business or (iii) any Disposition of such assets or rights by the Company (excluding any Disposition
with respect to a Fundamental Transaction), in an arms-length reasonable transaction, with aggregate gross cash proceeds of greater than
$5 million payable within 12 months after the date of consummation of such Disposition. Notwithstanding the foregoing, any waiver or
amendment of Section 17(b) of the Series A Certificate of Designations by the requisite Series A Investors shall be deemed to also apply
to this Section 17(b).
(c) Change
in Nature of Business. The Company shall not, and the Company shall cause each of its Subsidiaries to not, directly or indirectly,
engage in any material line of business substantially different from those lines of business conducted by or publicly contemplated to
be conducted by the Company and each of its Subsidiaries on the Subscription Date or any business substantially related or incidental
thereto. The Company shall not, and the Company shall cause each of its Subsidiaries to not, directly or indirectly, modify its or their
corporate structure or purpose.
(d) Preservation
of Existence, Etc. The Company shall maintain and preserve, and cause each of its Subsidiaries to maintain and preserve, its existence,
rights and privileges, and become or remain, and cause each of its Subsidiaries to become or remain, duly qualified and in good standing
in each jurisdiction in which the character of the properties owned or leased by it or in which the transaction of its business makes
such qualification necessary, except where the failure to become or remain duly qualified or in good standing could not reasonably be
expected to result in a Material Adverse Effect.
(e) Maintenance
of Properties, Etc. The Company shall maintain and preserve, and cause each of its Subsidiaries to maintain and preserve, all of
its material properties which are necessary or useful in the proper conduct of its business in good working order and condition, ordinary
wear and tear excepted, and comply, and cause each of its Subsidiaries to materially comply, at all times with the provisions of all
leases to which it is a party as lessee or under which it occupies property, so as to prevent any loss or forfeiture thereof or thereunder.
(f) Maintenance
of Intellectual Property. The Company will, and will cause each of its Subsidiaries to, take all action necessary or advisable to
maintain all of the Intellectual Property Rights of the Company and/or any of its Subsidiaries that are necessary or material to the
conduct of its business in full force and effect.
(g) Maintenance
of Insurance. The Company shall maintain, and cause each of its Subsidiaries to maintain, insurance with responsible and reputable
insurance companies or associations (including, without limitation, comprehensive general liability, hazard, rent and business interruption
insurance) with respect to its properties (including all real properties leased or owned by it) and business, in such amounts and covering
such risks as is required by any Governmental Authority having jurisdiction with respect thereto or as is carried generally in accordance
with sound business practice by companies in similar businesses similarly situated.
(h) Transactions
with Affiliates. The Company shall not, nor shall it permit any of its Subsidiaries to, enter into, renew, extend or be a party to,
any transaction or series of related transactions (including, without limitation, the purchase, sale, lease, transfer or exchange of
property or assets of any kind or the rendering of services of any kind) with any affiliate, except transactions in the ordinary course
of business in a manner and to an extent consistent with past practice and necessary or desirable for the prudent operation of its business,
for fair consideration and on terms no less favorable to it or its Subsidiaries than would be obtainable in a comparable arm’s
length transaction with a Person that is not an affiliate thereof.
(i) Restricted
Issuances. The Company shall not, directly or indirectly, without the prior written consent of the Required Holders, (i) issue any
Preferred Shares (other than as contemplated by the Securities Purchase Agreement and this Certificate of Designations), or (ii) issue
any other securities that would cause a breach or default under this Certificate of Designations. Notwithstanding the foregoing, any
waiver or amendment of the Section 17(i) of the Series A Certificate of Designations by the requisite Series A Investors shall be deemed
to also apply to this Section 17(i).
(j) Stay,
Extension and Usury Laws. To the extent that it may lawfully do so, the Company (A) agrees that it will not at any time insist upon,
plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law (wherever or whenever
enacted or in force) that may affect the covenants or the performance of this Certificate of Designations; and (B) expressly waives all
benefits or advantages of any such law and agrees that it will not, by resort to any such law, hinder, delay or impede the execution
of any power granted to the Holders by this Certificate of Designations, but will suffer and permit the execution of every such power
as though no such law has been enacted.
(k) Taxes.
The Company and its Subsidiaries shall pay when due all material taxes, fees or other charges of any nature whatsoever (together with
any related interest or penalties) now or hereafter imposed or assessed against the Company and its Subsidiaries or their respective
assets or upon their ownership, possession, use, operation or disposition thereof or upon their rents, receipts or earnings arising therefrom
(except where the failure to pay would not, individually or in the aggregate, have a material effect on the Company or any of its Subsidiaries).
The Company and its Subsidiaries shall file on or before the due date therefor all personal property tax returns (except where the failure
to file would not, individually or in the aggregate, have a material effect on the Company or any of its Subsidiaries). Notwithstanding
the foregoing, the Company and its Subsidiaries may contest, in good faith and by appropriate proceedings, taxes for which they maintain
adequate reserves therefor in accordance with GAAP.
(l) PCAOB
Registered Auditor. At all times any Preferred Shares remain outstanding, the Company shall have engaged an independent auditor to
audit its financial statements that is registered with (and in compliance with the rules and regulations of) the Public Company Accounting
Oversight Board.
(m)
Independent Investigation. At the request of the Required Holders either (x) at any time when a Triggering Event has occurred
and is continuing, (y) upon the occurrence of an event that with the passage of time or giving of notice would constitute a Triggering
Event or (z) at any time such Required Holders reasonably believe a Triggering Event may have occurred or be continuing, the Company
shall hire an independent, reputable investment bank selected by the Company and approved by such Holder (such approval not to be unreasonably
withheld, conditioned or delayed) to investigate as to whether any breach of this Certificate of Designations has occurred (the “Independent
Investigator”). If the Independent Investigator determines that such breach of this Certificate of Designations has occurred,
the Independent Investigator shall notify the Company of such breach and the Company shall deliver written notice to each Holder of such
breach. In connection with such investigation, the Independent Investigator may, during normal business hours, inspect all contracts,
books, records, personnel, offices and other facilities and properties of the Company and its Subsidiaries and, to the extent available
to the Company after the Company uses reasonable efforts to obtain them, the records of its legal advisors and accountants and any books
of account, records, reports and other papers not contractually required of the Company to be confidential or secret, or subject to attorney-client
or other evidentiary privilege, and the Independent Investigator may make such copies and inspections thereof as the Independent Investigator
may reasonably request. The Company shall furnish the Independent Investigator with such financial and operating data and other information
with respect to the business and properties of the Company as the Independent Investigator may reasonably request. The Company shall
permit the Independent Investigator to discuss the affairs, finances and accounts of the Company with, and to make proposals and furnish
advice with respect thereto to, the Company’s officers, directors, key employees and independent public accountants or any of them
(and by this provision the Company authorizes said accountants to discuss with such Independent Investigator the finances and affairs
of the Company and any Subsidiaries), all at such reasonable times, upon reasonable notice, and as often as may be reasonably requested.
18. Liquidation,
Dissolution, Winding-Up. In the event of a Liquidation Event, the Holders shall be entitled to receive in cash out of the assets
of the Company, whether from capital or from earnings available for distribution to its stockholders (the “Liquidation Funds”),
before any amount shall be paid to the holders of any of shares of Junior Stock, but pari passu with any Parity Stock then outstanding,
an amount per Preferred Share equal to the sum of the greater of (A) 125% of the Conversion Amount of such Preferred Share on the date
of such payment and (B) the amount per share such Holder would receive if such Holder converted such Preferred Share into Common Stock
immediately prior to the date of such payment, provided that if the Liquidation Funds are insufficient to pay the full amount due to
the Holders and holders of shares of Parity Stock, then each Holder and each holder of Parity Stock shall receive a percentage of the
Liquidation Funds equal to the full amount of Liquidation Funds payable to such Holder and such holder of Parity Stock as a liquidation
preference, in accordance with their respective certificate of designations (or equivalent), as a percentage of the full amount of Liquidation
Funds payable to all holders of Preferred Shares and all holders of shares of Parity Stock. To the extent necessary, the Company shall
cause such actions to be taken by each of its Subsidiaries so as to enable, to the maximum extent permitted by law, the proceeds of a
Liquidation Event to be distributed to the Holders in accordance with this Section 18. All the preferential amounts to be paid to the
Holders under this Section 18 shall be paid or set apart for payment before the payment or setting apart for payment of any amount for,
or the distribution of any Liquidation Funds of the Company to the holders of shares of Junior Stock in connection with a Liquidation
Event as to which this Section 18 applies.
19. Distribution
of Assets. In addition to any adjustments pursuant to Section 11 and Section 12, if the Company shall declare or make any dividend
or other distributions of its assets (or rights to acquire its assets) to any or all holders of shares of Common Stock, by way of return
of capital or otherwise (including without limitation, any distribution of cash, stock or other securities, property or options by way
of a dividend, spin off, reclassification, corporate rearrangement, scheme of arrangement or other similar transaction) (the “Distributions”),
then each Holder, as holders of Preferred Shares, will be entitled to such Distributions as if such Holder had held the number of shares
of Common Stock acquirable upon complete conversion of the Preferred Shares (without taking into account any limitations or restrictions
on the convertibility of the Preferred Shares and assuming for such purpose that the Preferred Share was converted at the Alternate Conversion
Price as of the applicable record date) immediately prior to the date on which a record is taken for such Distribution or, if no such
record is taken, the date as of which the record holders of Common Stock are to be determined for such Distributions (provided,
however, that to the extent that such Holder’s right to participate in any such Distribution would result in such Holder
and the other Attribution Parties exceeding the Maximum Percentage, then such Holder shall not be entitled to participate in such Distribution
to such extent of the Maximum Percentage (and shall not be entitled to beneficial ownership of such shares of Common Stock as a result
of such Distribution (and beneficial ownership) to such extent of any such excess) and the portion of such Distribution shall be held
in abeyance for the benefit of such Holder until such time or times as its right thereto would not result in such Holder and the other
Attribution Parties exceeding the Maximum Percentage, at which time or times, if any, such Holder shall be granted such Distribution
(and any Distributions declared or made on such initial Distribution or on any subsequent Distribution held similarly in abeyance) to
the same extent as if there had been no such limitation).
20. Vote
to Change the Terms of or Issue Preferred Shares. In addition to any other rights provided by law, except where the vote or written
consent of the holders of a greater number of shares is required by law or by another provision of the Certificate of Incorporation,
without first obtaining the affirmative vote at a meeting duly called for such purpose or the written consent without a meeting of the
Required Holders, voting together as a single class, the Company shall not: (a) amend or repeal any provision of, or add any provision
to, its Certificate of Incorporation or bylaws, or file any certificate of designations or articles of amendment of any series of shares
of preferred stock, if such action would adversely alter or change in any respect the preferences, rights, privileges or powers, or restrictions
provided for the benefit of the Preferred Shares hereunder, regardless of whether any such action shall be by means of amendment to the
Certificate of Incorporation or by merger, consolidation or otherwise; (b) increase or decrease (other than by conversion) the authorized
number of shares of Series B Convertible Preferred Stock; (c) without limiting any provision of Section 2, create or authorize (by reclassification
or otherwise) any new class or series of Senior Preferred Stock or Parity Stock; (d) purchase, repurchase or redeem any shares of Junior
Stock (other than pursuant to the terms of the Company’s equity incentive plans and options and other equity awards granted under
such plans (that have in good faith been approved by the Board)); (e) without limiting any provision of Section 2, pay dividends or make
any other distribution on any shares of any Junior Stock; (f) issue any Preferred Shares other than as contemplated hereby or pursuant
to the Securities Purchase Agreement; or (g) without limiting any provision of Section 14, whether or not prohibited by the terms of
the Preferred Shares, circumvent a right of the Preferred Shares hereunder.
21. Transfer
of Preferred Shares. A Holder may offer, sell or transfer some or all of its Preferred Shares without the consent of the Company
subject only to the provisions of Section 5 of the Securities Purchase Agreement.
22. Reissuance
of Preferred Share Certificates and Book Entries.
(a) Transfer.
If any Preferred Shares are to be transferred, the applicable Holder shall surrender the applicable Preferred Share Certificate to the
Company (or, if the Preferred Shares are held in Book-Entry form, a written instruction letter to the Company), whereupon the Company
will forthwith issue and deliver upon the order of such Holder a new Preferred Share Certificate (in accordance with Section 22(d)) (or
evidence of the transfer of such Book-Entry), registered as such Holder may request, representing the outstanding number of Preferred
Shares being transferred by such Holder and, if less than the entire outstanding number of Preferred Shares is being transferred, a new
Preferred Share Certificate (in accordance with Section 22(d)) to such Holder representing the outstanding number of Preferred Shares
not being transferred (or evidence of such remaining Preferred Shares in a Book-Entry for such Holder). Such Holder and any assignee,
by acceptance of the Preferred Share Certificate or evidence of Book-Entry issuance, as applicable, acknowledge and agree that, by reason
of the provisions of Section 4(c)(i) following conversion or redemption of any of the Preferred Shares, the outstanding number of Preferred
Shares represented by the Preferred Shares may be less than the number of Preferred Shares stated on the face of the Preferred Shares.
(b) Lost,
Stolen or Mutilated Preferred Share Certificate. Upon receipt by the Company of evidence reasonably satisfactory to the Company of
the loss, theft, destruction or mutilation of a Preferred Share Certificate (as to which a written certification and the indemnification
contemplated below shall suffice as such evidence), and, in the case of loss, theft or destruction, of any indemnification undertaking
by the applicable Holder to the Company in customary and reasonable form and, in the case of mutilation, upon surrender and cancellation
of such Preferred Share Certificate, the Company shall execute and deliver to such Holder a new Preferred Share Certificate (in accordance
with Section 22(d)) representing the applicable outstanding number of Preferred Shares.
(c) Preferred
Share Certificate and Book-Entries Exchangeable for Different Denominations and Forms. Each Preferred Share Certificate is exchangeable,
upon the surrender hereof by the applicable Holder at the principal office of the Company, for a new Preferred Share Certificate or Preferred
Share Certificate(s) or new Book-Entry (in accordance with Section 22(d)) representing, in the aggregate, the outstanding number of the
Preferred Shares in the original Preferred Share Certificate, and each such new Preferred Share Certificate and/or new Book-Entry, as
applicable, will represent such portion of such outstanding number of Preferred Shares from the original Preferred Share Certificate
as is designated in writing by such Holder at the time of such surrender. Each Book-Entry may be exchanged into one or more new Preferred
Share Certificates or split by the applicable Holder by delivery of a written notice to the Company into two or more new Book-Entries
(in accordance with Section 22(d)) representing, in the aggregate, the outstanding number of the Preferred Shares in the original Book-Entry,
and each such new Book-Entry and/or new Preferred Share Certificate, as applicable, will represent such portion of such outstanding number
of Preferred Shares from the original Book-Entry as is designated in writing by such Holder at the time of such surrender.
(d) Issuance
of New Preferred Share Certificate or Book-Entry. Whenever the Company is required to issue a new Preferred Share Certificate or
a new Book-Entry pursuant to the terms of this Certificate of Designations, such new Preferred Share Certificate or new Book-Entry (i)
shall represent, as indicated on the face of such Preferred Share Certificate or in such Book-Entry, as applicable, the number of Preferred
Shares remaining outstanding (or in the case of a new Preferred Share Certificate or new Book-Entry being issued pursuant to Section
22(a) or Section 22(c), the number of Preferred Shares designated by such Holder) which, when added to the number of Preferred Shares
represented by the other new Preferred Share Certificates or other new Book-Entry, as applicable, issued in connection with such issuance,
does not exceed the number of Preferred Shares remaining outstanding under the original Preferred Share Certificate or original Book-Entry,
as applicable, immediately prior to such issuance of new Preferred Share Certificate or new Book-Entry, as applicable, and (ii) shall
have an issuance date, as indicated on the face of such new Preferred Share Certificate or in such new Book-Entry, as applicable, which
is the same as the issuance date of the original Preferred Share Certificate or in such original Book-Entry, as applicable.
23. Remedies,
Characterizations, Other Obligations, Breaches and Injunctive Relief. The remedies provided in this Certificate of Designations shall
be cumulative and in addition to all other remedies available under this Certificate of Designations and any of the other Transaction
Documents, at law or in equity (including a decree of specific performance and/or other injunctive relief), and nothing herein shall
limit any Holder’s right to pursue actual and consequential damages for any failure by the Company to comply with the terms of
this Certificate of Designations. No failure on the part of a Holder to exercise, and no delay in exercising, any right, power or remedy
hereunder shall operate as a waiver thereof; nor shall any single or partial exercise by such Holder of any right, power or remedy preclude
any other or further exercise thereof or the exercise of any other right, power or remedy. In addition, the exercise of any right or
remedy of a Holder at law or equity or under this Certificate of Designations or any of the documents shall not be deemed to be an election
of such Holder’s rights or remedies under such documents or at law or equity. The Company covenants to each Holder that there shall
be no characterization concerning this instrument other than as expressly provided herein. Amounts set forth or provided for herein with
respect to payments, conversion and the like (and the computation thereof) shall be the amounts to be received by a Holder and shall
not, except as expressly provided herein, be subject to any other obligation of the Company (or the performance thereof). No failure
on the part of a Holder to exercise, and no delay in exercising, any right, power or remedy hereunder shall operate as a waiver thereof;
nor shall any single or partial exercise by such Holder of any right, power or remedy preclude any other or further exercise thereof
or the exercise of any other right, power or remedy. In addition, the exercise of any right or remedy of any Holder at law or equity
or under Preferred Shares or any of the documents shall not be deemed to be an election of such Holder’s rights or remedies under
such documents or at law or equity. The Company acknowledges that a breach by it of its obligations hereunder will cause irreparable
harm to the Holders and that the remedy at law for any such breach may be inadequate. The Company therefore agrees that, in the event
of any such breach or threatened breach, each Holder shall be entitled, in addition to all other available remedies, to specific performance
and/or temporary, preliminary and permanent injunctive or other equitable relief from any court of competent jurisdiction in any such
case without the necessity of proving actual damages and without posting a bond or other security. The Company shall provide all information
and documentation to a Holder that is requested by such Holder to enable such Holder to confirm the Company’s compliance with the
terms and conditions of this Certificate of Designations.
24. Payment
of Collection, Enforcement and Other Costs. If (a) any Preferred Shares are placed in the hands of an attorney for collection or
enforcement or is collected or enforced through any legal proceeding or a Holder otherwise takes action to collect amounts due under
this Certificate of Designations with respect to the Preferred Shares or to enforce the provisions of this Certificate of Designations
or (b) there occurs any bankruptcy, reorganization, receivership of the Company or other proceedings affecting Company creditors’
rights and involving a claim under this Certificate of Designations, then the Company shall pay the costs reasonably incurred by such
Holder for such collection, enforcement or action or in connection with such bankruptcy, reorganization, receivership or other proceeding,
including, without limitation, attorneys’ fees and disbursements. The Company expressly acknowledges and agrees that no amounts
due under this Certificate of Designations with respect to any Preferred Shares shall be affected, or limited, by the fact that the purchase
price paid for each Preferred Share was less than the original Stated Value thereof.
25. Construction;
Headings. This Certificate of Designations shall be deemed to be jointly drafted by the Company and the Holders and shall not be
construed against any such Person as the drafter hereof. The headings of this Certificate of Designations are for convenience of reference
and shall not form part of, or affect the interpretation of, this Certificate of Designations. Unless the context clearly indicates otherwise,
each pronoun herein shall be deemed to include the masculine, feminine, neuter, singular and plural forms thereof. The terms “including,”
“includes,” “include” and words of like import shall be construed broadly as if followed by the words “without
limitation.” The terms “herein,” “hereunder,” “hereof” and words of like import refer to this
entire Certificate of Designations instead of just the provision in which they are found. Unless expressly indicated otherwise, all section
references are to sections of this Certificate of Designations. Terms used in this Certificate of Designations and not otherwise defined
herein, but defined in the other Transaction Documents, shall have the meanings ascribed to such terms on the Initial Issuance Date in
such other Transaction Documents unless otherwise consented to in writing by the Required Holders.
26. Failure
or Indulgence Not Waiver. No failure or delay on the part of a Holder in the exercise of any power, right or privilege hereunder
shall operate as a waiver thereof, nor shall any single or partial exercise of any such power, right or privilege preclude other or further
exercise thereof or of any other right, power or privilege. No waiver shall be effective unless it is in writing and signed by an authorized
representative of the waiving party. This Certificate of Designations shall be deemed to be jointly drafted by the Company and all Holders
and shall not be construed against any Person as the drafter hereof. Notwithstanding the foregoing, nothing contained in this Section
26 shall permit any waiver of any provision of Section 5(a).
27. Dispute
Resolution.
(a) Submission
to Dispute Resolution.
(i)
In the case of a dispute relating to a Closing Bid Price, a Closing Sale Price, a Conversion Price, an Alternate Conversion Price, a
VWAP or a fair market value or the arithmetic calculation of a Conversion Rate, or the applicable redemption price (as the case may
be) (including, without limitation, a dispute relating to the determination of any of the foregoing), the Company or the applicable
Holder (as the case may be) shall submit the dispute to the other party via electronic mail (A) if by the Company, within two (2)
Business Days after the occurrence of the circumstances giving rise to such dispute or (B) if by such Holder at any time after such
Holder learned of the circumstances giving rise to such dispute. If such Holder and the Company are unable to promptly resolve such
dispute relating to such Closing Bid Price, such Closing Sale Price, such Conversion Price, such Alternate Conversion Price, such
VWAP or such fair market value, or the arithmetic calculation of such Conversion Rate or such applicable redemption price (as the
case may be), at any time after the second (2nd) Business Day following such initial notice by the Company or such Holder
(as the case may be) of such dispute to the Company or such Holder (as the case may be), then such Holder may, with the consent of
the Company (not to be unreasonably withheld, conditioned or delayed), select an independent, reputable investment bank to resolve
such dispute.
(ii)
Such Holder and the Company shall each deliver to such investment bank (A) a copy of the initial dispute submission so delivered in accordance
with the first sentence of this Section 27 and (B) written documentation supporting its position with respect to such dispute, in each
case, no later than 5:00 p.m. (New York time) by the fifth (5th) Business Day immediately following the date on which such
Holder selected such investment bank (the “Dispute Submission Deadline”) (the documents referred to in the immediately
preceding clauses (A) and (B) are collectively referred to herein as the “Required Dispute Documentation”) (it being
understood and agreed that if either such Holder or the Company fails to so deliver all of the Required Dispute Documentation by the
Dispute Submission Deadline, then the party who fails to so submit all of the Required Dispute Documentation shall no longer be entitled
to (and hereby waives its right to) deliver or submit any written documentation or other support to such investment bank with respect
to such dispute and such investment bank shall resolve such dispute based solely on the Required Dispute Documentation that was delivered
to such investment bank prior to the Dispute Submission Deadline). Unless otherwise agreed to in writing by both the Company and such
Holder or otherwise requested by such investment bank, neither the Company nor such Holder shall be entitled to deliver or submit any
written documentation or other support to such investment bank in connection with such dispute (other than the Required Dispute Documentation).
(iii)
The Company and such Holder shall cause such investment bank to determine the resolution of such dispute and notify the Company and such
Holder of such resolution no later than ten (10) Business Days immediately following the Dispute Submission Deadline. The fees and expenses
of such investment bank shall be borne by the party in whose favor the investment bank decides such dispute or, in the event that the
investment bank determines that the applicable calculation is in between the amounts submitted by the Company and such Holder, then half
of such fees and expenses shall be borne by the Company and half of such fees and expenses shall be borne by the Holder, and such investment
bank’s resolution of such dispute shall be final and binding upon all parties absent manifest error.
(b) Miscellaneous.
The Company expressly acknowledges and agrees that (i) this Section 27 constitutes an agreement to arbitrate between the Company and
each Holder (and constitutes an arbitration agreement) under the rules then in effect under Delaware Rapid Arbitration Act, as amended,
(ii) the terms of this Certificate of Designations and each other applicable Transaction Document shall serve as the basis for the selected
investment bank’s resolution of the applicable dispute, such investment bank shall be entitled (and is hereby expressly authorized)
to make all findings, determinations and the like that such investment bank determines are required to be made by such investment bank
in connection with its resolution of such dispute and in resolving such dispute such investment bank shall apply such findings, determinations
and the like to the terms of this Certificate of Designations and any other applicable Transaction Documents, (iii) the applicable Holder
(and only such Holder with respect to disputes solely relating to such Holder), in its sole discretion, shall have the right to submit
any dispute described in this Section 27 to any state or federal court sitting in Wilmington Delaware, in lieu of utilizing the procedures
set forth in this Section 27 and (iv) nothing in this Section 27 shall limit such Holder from obtaining any injunctive relief or other
equitable remedies (including, without limitation, with respect to any matters described in this Section 27).
28. Notices;
Currency; Payments.
(a) Any
notices, consents, waivers or other communications required or permitted to be given under the terms of this Certificate of Designations
must be in writing and will be deemed to have been delivered on the earliest of: (i) upon receipt, when delivered personally; (ii) upon
receipt, when sent by electronic mail (provided that such sent email is kept on file (whether electronically or otherwise) by the sending
party and the sending party does not receive an automatically generated message from the recipient’s email server that such e-mail
could not be delivered to such recipient); or (iii) one (1) Business Day after deposit with an overnight courier service with next day
delivery specified, in each case, properly addressed to the party to receive the same. The mailing address and e-mail address for any
such communications to the Company shall be: CERo Therapeutics Holdings, Inc., 201 Haskins Way, #230, South San Francisco, CA 94080 Attention:
Charles Carter, e-mail address: ccarter@cero.bio, or such other mailing address and/or e-mail address as the Company has specified by
written notice given to each of the Holders in accordance with this Section 28(a) not later than five (5) days prior to the effectiveness
of such change. The mailing address and e-mail address for any such communications to any Holder shall be as set forth on such Holder’s
respective signature page to the Securities Purchase Agreement, or such other mailing address and/or e-mail address as such Holder has
specified by written notice given to the Company in accordance with this Section 28(a) not later than five (5) days prior to the effectiveness
of such change. Written confirmation of receipt (A) given by the recipient of such notice, consent, waiver or other communication, (B)
mechanically or electronically generated by the sender’s e-mail containing the time, date and recipient’s e-mail or (C) provided
by an overnight courier service shall be rebuttable evidence of personal service, receipt by e-mail or receipt from an overnight courier
service in accordance with clause (i), (ii) or (iii) above, respectively.
(b) The
Company shall provide each Holder with prompt written notice of all actions taken pursuant to this Certificate of Designations, including
in reasonable detail a description of such action and the reason therefore. Without limiting the generality of the foregoing, the Company
shall give written notice to each Holder (i) immediately upon any adjustment of the Conversion Price, setting forth in reasonable detail,
and certifying, the calculation of such adjustment and (ii) at least fifteen (15) days prior to the date on which the Company closes
its books or takes a record (A) with respect to any dividend or distribution upon the Common Stock, or (B) for determining rights to
vote with respect to any Fundamental Transaction, dissolution or liquidation, provided in each case that such information shall be made
known to the public prior to or in conjunction with such notice being provided to such Holder.
(c) Currency.
All dollar amounts referred to in this Certificate of Designations are in United States Dollars (“U.S. Dollars”),
and all amounts owing under this Certificate of Designations shall be paid in U.S. Dollars. All amounts denominated in other currencies
(if any) shall be converted into the U.S. Dollar equivalent amount in accordance with the Exchange Rate on the date of calculation. “Exchange
Rate” means, in relation to any amount of currency to be converted into U.S. Dollars pursuant to this Certificate of Designations,
the U.S. Dollar exchange rate as published in the Wall Street Journal on the relevant date of calculation (it being understood and agreed
that where an amount is calculated with reference to, or over, a period of time, the date of calculation shall be the final date of such
period of time).
(d) Payments.
Whenever any payment of cash is to be made by the Company to any Person pursuant to this Certificate of Designations, unless otherwise
expressly set forth herein, such payment shall be made in lawful money of the United States of America by wire transfer of immediately
available funds pursuant to wire transfer instructions that Holder shall provide to the Company in writing from time to time. Whenever
any amount expressed to be due by the terms of this Certificate of Designations is due on any day which is not a Business Day, the same
shall instead be due on the next succeeding day which is a Business Day.
29. Waiver
of Notice. To the extent permitted by law, the Company hereby irrevocably waives demand, notice, presentment, protest and all other
demands and notices in connection with the delivery, acceptance, performance, default or enforcement of this Certificate of Designations
and the Securities Purchase Agreement.
30. Governing
Law. This Certificate of Designations shall be construed and enforced in accordance with, and all questions concerning the construction,
validity, interpretation and performance of this Certificate of Designations shall be governed by, the internal laws of the State of
Delaware, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of Delaware or any other
jurisdictions) that would cause the application of the laws of any jurisdictions other than the State of Delaware. Except as otherwise
required by Section 27 above, the Company hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting
in Wilmington, Delaware, for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated
hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that
it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient
forum or that the venue of such suit, action or proceeding is improper. Nothing contained herein shall be deemed to limit in any way
any right to serve process in any manner permitted by law. Nothing contained herein shall be deemed to limit in any way any right to
serve process in any manner permitted by law. Nothing contained herein (i) shall be deemed or operate to preclude any Holder from bringing
suit or taking other legal action against the Company in any other jurisdiction to collect on the Company’s obligations to such
Holder, to realize on any collateral or any other security for such obligations, or to enforce a judgment or other court ruling in favor
of such Holder or (ii) shall limit, or shall be deemed or construed to limit, any provision of Section 27 above. THE COMPANY AND EACH
HOLDER HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE TO, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE
HEREUNDER OR IN CONNECTION WITH OR ARISING OUT OF THIS CERTIFICATE OF DESIGNATIONS OR ANY TRANSACTION CONTEMPLATED HEREBY.
31. Judgment
Currency.
(a) If
for the purpose of obtaining or enforcing judgment against the Company in any court in any jurisdiction it becomes necessary to convert
into any other currency (such other currency being hereinafter in this Section 31 referred to as the “Judgment Currency”)
an amount due in U.S. Dollars under this Certificate of Designations, the conversion shall be made at the Exchange Rate prevailing on
the Trading Day immediately preceding:
(i)
the date actual payment of the amount due, in the case of any proceeding in the courts of New York or in the courts of any other jurisdiction
that will give effect to such conversion being made on such date: or
(ii)
the date on which the foreign court determines, in the case of any proceeding in the courts of any other jurisdiction (the date as of
which such conversion is made pursuant to this Section 31(a)(ii) being hereinafter referred to as the “Judgment Conversion Date”).
(b) If
in the case of any proceeding in the court of any jurisdiction referred to in Section 31(a)(ii) above, there is a change in the Exchange
Rate prevailing between the Judgment Conversion Date and the date of actual payment of the amount due, the applicable party shall pay
such adjusted amount as may be necessary to ensure that the amount paid in the Judgment Currency, when converted at the Exchange Rate
prevailing on the date of payment, will produce the amount of US dollars which could have been purchased with the amount of Judgment
Currency stipulated in the judgment or judicial order at the Exchange Rate prevailing on the Judgment Conversion Date.
(c) Any
amount due from the Company under this provision shall be due as a separate debt and shall not be affected by judgment being obtained
for any other amounts due under or in respect of this Certificate of Designations.
32. TAXES.
(a) All
payments made by the Company hereunder or under any other Transaction Document shall be made in accordance with the terms of the respective
Transaction Document and shall be made without set-off, counterclaim, withholding, deduction or other defense. Without limiting the foregoing,
all such payments shall be made free and clear of and without deduction or withholding for any present or future taxes, levies, imposts,
deductions, charges or withholdings, and all liabilities with respect thereto, excluding (i) taxes imposed on the net income of a Holder
by the jurisdiction in which such Holder is organized or where it has its principal lending office, (ii) with respect to any payments
made by the Company hereunder, taxes (including, but not limited to, backup withholding) to the extent such taxes are imposed due to
the failure of the applicable recipient of such payment to provide the Company with whichever (if any) is applicable of valid and properly
completed and executed IRS Forms W-9, W-8BEN, W-8BEN-E, W-8ECI, and/or W-8IMY, when requested in writing by the Company, and (iii) with
respect to any payments made by the Company, taxes to the extent such taxes are imposed due to the failure of the applicable recipient
of such payment to comply with FATCA (all such nonexcluded taxes, levies, imposts, deductions, charges, withholdings and liabilities,
collectively or individually, “Taxes”). If the Company shall be required to deduct or to withhold any Taxes from or
in respect of any amount payable hereunder or under any other Transaction Document:
(i)
the amount so payable shall be increased to the extent necessary so that after making all required deductions and withholdings (including
Taxes on amounts payable to a Holder pursuant to this sentence) such Holder receives an amount equal to the sum it would have received
had no such deduction or withholding been made,
(ii)
the Company shall make such deduction or withholding,
(iii)
the Company shall pay the full amount deducted or withheld to the relevant Governmental Authority in accordance with applicable law,
and
(iv)
as promptly as possible thereafter, the Company shall send such Holder an official receipt (or, if an official receipt is not available,
such other documentation as shall be satisfactory to such Holder, as the case may be) showing payment. In addition, the Company agrees
to pay any present or future stamp or documentary taxes or any other excise or property taxes, charges or similar levies that arise from
any payment made hereunder or from the execution, delivery, registration or enforcement of, or otherwise with respect to, this Preferred
Shares or any other Transaction Document (collectively, “Other Taxes”).
(b) The
Company hereby indemnifies and agrees to hold each Holder and each of their affiliates and their respective officers, directors, employees,
agents and advisors (each, an “Indemnified Party”) each Indemnified Party harmless from and against Taxes or Other
Taxes (including, without limitation, any Taxes or Other Taxes imposed by any jurisdiction on amounts payable under this Section 32)
paid by any Indemnified Party as a result of any payment made hereunder or from the execution, delivery, registration or enforcement
of, or otherwise with respect to, this Preferred Shares or any other Transaction Document, and any liability (including penalties, interest
and expenses for nonpayment, late payment or otherwise) arising therefrom or with respect thereto, whether or not such Taxes or Other
Taxes were correctly or legally asserted. This indemnification shall be paid within thirty (30) days from the date on which such Holder
makes written demand therefor, which demand shall identify the nature and amount of such Taxes or Other Taxes.
(c) If
the Company fails to perform any of its obligations under this Section 32, the Company shall indemnify such Holder for any taxes, interest
or penalties that may become payable as a result of any such failure. The obligations of the Company under this Section 32 shall survive
the repayment and/or conversion, as applicable, in full of the Preferred Shares and all other amounts payable with respect thereto.
(d) If
any Indemnified Party determines, in its sole discretion exercised in good faith, that it has received a refund of any Taxes as to which
it has been indemnified pursuant to this Section 32 (including by the payment of additional amounts pursuant to this Section 32), it
shall pay to the indemnifying party an amount equal to such refund (but only to the extent of indemnity payments made under this Section
32 with respect to the Taxes giving rise to such refund), net of all out-of-pocket expenses (including taxes) of such Indemnified Party
and without interest (other than any interest paid by the relevant Governmental Authority with respect to such refund). Such indemnifying
party, upon the request of such Indemnified Party, shall repay to such Indemnified Party the amount paid over pursuant to this paragraph
(d) (plus any penalties, interest, or other charges imposed by the relevant Governmental Authority) in the event that such Indemnified
Party is required to repay such refund to such Governmental Authority. Notwithstanding anything to the contrary in this paragraph (d),
in no event will the Indemnified Party be required to pay any amount to an indemnifying party pursuant to this paragraph (d) the payment
of which would place the Indemnified Party in a less favorable net after-Tax position than the Indemnified Party would have been in if
the Tax subject to indemnification and giving rise to such refund had not been deducted, withheld or otherwise imposed and the indemnification
payments or additional amounts with respect to such Tax had never been paid. This paragraph (d) shall not be construed to require any
Indemnified Party to make available its Tax returns (or any other information relating to its Taxes that it deems confidential) to the
indemnifying party or any other Person.
33. Severability.
If any provision of this Certificate of Designations is prohibited by law or otherwise determined to be invalid or unenforceable by a
court of competent jurisdiction, the provision that would otherwise be prohibited, invalid or unenforceable shall be deemed amended to
apply to the broadest extent that it would be valid and enforceable, and the invalidity or unenforceability of such provision shall not
affect the validity of the remaining provisions of this Certificate of Designations so long as this Certificate of Designations as so
modified continues to express, without material change, the original intentions of the parties as to the subject matter hereof and the
prohibited nature, invalidity or unenforceability of the provision(s) in question does not substantially impair the respective expectations
or reciprocal obligations of the parties or the practical realization of the benefits that would otherwise be conferred upon the parties.
The parties will endeavor in good faith negotiations to replace the prohibited, invalid or unenforceable provision(s) with a valid provision(s),
the effect of which comes as close as possible to that of the prohibited, invalid or unenforceable provision(s).
34. Maximum
Payments. Without limitation Section 9(d) of the Securities Purchase Agreement, nothing contained herein shall be deemed to establish
or require the payment of a rate of interest or other charges in excess of the maximum permitted by applicable law. In the event that
the rate of interest required to be paid or other charges hereunder exceed the maximum permitted by such law, any payments in excess
of such maximum shall be credited against amounts owed by the Company to the applicable Holder and thus refunded to the Company.
35. Stockholder
Matters; Amendment.
(a) Stockholder
Matters. Any stockholder action, approval or consent required, desired or otherwise sought by the Company pursuant to the DGCL, the
Certificate of Incorporation, this Certificate of Designations or otherwise with respect to the issuance of Preferred Shares may be effected
by written consent of the Company’s stockholders or at a duly called meeting of the Company’s stockholders, all in accordance
with the applicable rules and regulations of the DGCL. This provision is intended to comply with the applicable sections of the DGCL
permitting stockholder action, approval and consent affected by written consent in lieu of a meeting.
(b) Amendment.
Except for Section 5(a), which may not be amended or waived hereunder, this Certificate of Designations or any provision hereof may be
amended by obtaining the affirmative vote at a meeting duly called for such purpose, or written consent without a meeting in accordance
with the DGCL, of the Required Holders, voting separate as a single class, and with such other stockholder approval, if any, as may then
be required pursuant to the DGCL and the Certificate of Incorporation. Except (a) to the extent otherwise expressly provided in
this Certificate of Designations or the Certificate of Incorporation with respect to voting or approval rights of a particular class
or series of capital stock or (b) to the extent otherwise provided pursuant to the DGCL, the holders of each outstanding class or
series of shares of the Company shall not be entitled to vote as a separate voting group on any amendment to the terms of this Certificate
of Designations with respect to which such class or series would otherwise be entitled under the DGCL to vote as a separate voting
group.
36. Certain
Defined Terms. For purposes of this Certificate of Designations, the following terms shall have the following meanings:
(a)
“1933 Act” means the Securities Act of 1933, as amended, and the rules and regulations thereunder.
(b)
“1934 Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder.
(c)
“Additional Amount” means, as of the applicable date of determination, with respect to each Preferred Share, all
declared and unpaid Dividends on such Preferred Share.
(d)
“Adjustment Right” means any right granted with respect to any securities issued in connection with, or with
respect to, any issuance or sale (or deemed issuance or sale in accordance with Section 12(a)) of shares of Common Stock (other than
rights of the type described in Section 11(a) hereof) that could result in a decrease in the net consideration received by the
Company in connection with, or with respect to, such securities (including, without limitation, any cash settlement rights, cash
adjustment or other similar rights).
(e)
“Affiliate” or “Affiliated” means, with respect to any Person, any other Person that directly or
indirectly controls, is controlled by, or is under common control with, such Person, it being understood for purposes of this definition
that “control” of a Person means the power directly or indirectly either to vote 10% or more of the stock having ordinary
voting power for the election of directors of such Person or direct or cause the direction of the management and policies of such Person
whether by contract or otherwise.
(f)
“Alternate Conversion Price” means, with respect to any Alternate Conversion that price which shall be the lowest
of (i) the applicable Conversion Price as in effect on the applicable Conversion Date of the applicable Alternate Conversion, and
(ii) the greater of (x) the Floor Price and (y) 80% of the lowest VWAP of the Common Stock during the five (5) consecutive Trading
Day period ending and including the Trading Day immediately preceding the delivery or deemed delivery of the applicable Conversion
Notice (such period, the “Alternate Conversion Measuring Period”). All such determinations to be appropriately
adjusted for any stock dividend, stock split, stock combination, reclassification or similar transaction that proportionately
decreases or increases the Common Stock during such Alternate Conversion Measuring Period.
(g) “Alternate
Conversion Floor Amount” means an amount equal to the product obtained by multiplying (A) the higher of (I) the highest price
that the Common Stock trades at on the Trading Day immediately preceding the relevant Alternate Conversion Date and (II) the applicable
Alternate Conversion Price and (B) the difference obtained by subtracting (I) the number of shares of Common Stock delivered (or to be
delivered) to such Holder on the applicable Share Delivery Deadline with respect to such Alternate Conversion from (II) the quotient
obtained by dividing (x) the applicable Conversion Amount that such Holder has elected to be the subject of the applicable Alternate
Conversion, by (y) the applicable Alternate Conversion Price without giving effect to clause (x) of such definition.
(h) “Applicable
Date” means the later of (x) the Stockholder Approval Date and (y) the earlier to occur of (A) the effective date of a registration
statement registering the resale by the Holders of the Required Registration Amount (as defined in the Registration Rights Agreement)
of the shares of Common Stock issuable upon conversion of the Preferred Shares then outstanding and (B) the date the Preferred Shares
are eligible to be resold by the Holders (assuming such Holders are not then affiliates of the Company) without restriction under Rule
144 of the 1933 Act (in each case, without regard to any limitations on exercise herein).
(i)
“Approved Stock Plan” means any employee benefit plan or agreement which has been approved by the Board prior to
or subsequent to the Subscription Date pursuant to which shares of Common Stock and standard options to purchase Common Stock may be
issued to any employee, officer, consultant or director for services provided to the Company in their capacity as such.
(j)
“Attribution Parties” means, collectively, the following Persons and entities: (i) any investment vehicle, including,
any funds, feeder funds or managed accounts, currently, or from time to time after the Initial Issuance Date, directly or indirectly
managed or advised by a Holder’s investment manager or any of its Affiliates or principals, (ii) any direct or indirect Affiliates
of such Holder or any of the foregoing, (iii) any Person acting or who could be deemed to be acting as a Group together with such Holder
or any of the foregoing and (iv) any other Persons whose beneficial ownership of the Company’s Common Stock would or could be aggregated
with such Holder’s and the other Attribution Parties for purposes of Section 13(d) of the 1934 Act. For clarity, the purpose of
the foregoing is to subject collectively such Holder and all other Attribution Parties to the Maximum Percentage.
(k)
“Bloomberg” means Bloomberg, L.P.
(l)
“Book-Entry” means each entry on the Register evidencing one or more Preferred Shares held by a Holder in lieu of
a Preferred Share Certificate issuable hereunder.
(m)
“Business Day” means any day other than Saturday, Sunday or other day on which commercial banks in The City of
New York are authorized or required by law to remain closed; provided, however, for clarification, commercial banks
shall not be deemed to be authorized or required by law to remain closed due to “stay at home”,
“shelter-in-place”, “non-essential employee” or any other similar orders or restrictions or the
closure of any physical branch locations at the direction of any Governmental Authority so long as the electronic funds transfer
systems (including for wire transfers) of commercial banks in The City of New York generally are open for use by customers on such
day.
(n)
“Change of Control” means any Fundamental Transaction other than (i) any merger of the Company or any of its,
direct or indirect, wholly-owned Subsidiaries with or into any of the foregoing Persons, (ii) any reorganization, recapitalization
or reclassification of the shares of Common Stock in which holders of the Company’s voting power immediately prior to such
reorganization, recapitalization or reclassification continue after such reorganization, recapitalization or reclassification to
hold publicly traded securities and, directly or indirectly, are, in all material respects, the holders of the voting power of the
surviving entity (or entities with the authority or voting power to elect the members of the board of directors (or their
equivalent if other than a corporation) of such entity or entities) after such reorganization, recapitalization or reclassification,
or (iii) pursuant to a migratory merger effected solely for the purpose of changing the jurisdiction of incorporation of the Company
or any of its Subsidiaries.
(o)
“Change of Control Election Price” means, with respect to any given Change of Control, such price equal to the
greatest of (i) the product of (A) the Required Premium multiplied by (B) the Conversion Amount of the Preferred Shares subject to
the applicable election, as applicable, (ii) the product of (A) the Conversion Amount of the Preferred Shares being redeemed or
exchanged, as applicable, multiplied by (B) the quotient determined by dividing (I) the greatest Closing Sale Price of the shares of
Common Stock during the period beginning on the date immediately preceding the earlier to occur of (1) the consummation of the
applicable Change of Control and (2) the public announcement of such Change of Control and ending on the date such Holder delivers
the Change of Control Election Notice by (II) the Alternate Conversion Price then in effect, and (iii) the product of (A) the
Conversion Amount of the Preferred Shares being redeemed multiplied by (B) the quotient of (I) the aggregate cash consideration and
the aggregate cash value of any non-cash consideration per share of Common Stock to be paid to such holders of the shares of Common
Stock upon consummation of such Change of Control (any such non-cash consideration constituting publicly-traded securities shall be
valued at the highest of the Closing Sale Price of such securities as of the Trading Day immediately prior to the consummation of
such Change of Control, the Closing Sale Price of such securities on the Trading Day immediately following the public announcement
of such proposed Change of Control and the Closing Sale Price of such securities on the Trading Day immediately prior to the public
announcement of such proposed Change of Control) divided by (II) the Conversion Price then in effect.
(p)
“Closing Bid Price” and “Closing Sale Price” means, for any security as of any date, the last
closing bid price and last closing trade price, respectively, for such security on the Principal Market, as reported by Bloomberg,
or, if the Principal Market begins to operate on an extended hours basis and does not designate the closing bid price or the closing
trade price (as the case may be) then the last bid price or last trade price, respectively, of such security prior to 4:00:00 p.m.,
New York time, as reported by Bloomberg, or, if the Principal Market is not the principal securities exchange or trading market for
such security, the last closing bid price or last trade price, respectively, of such security on the principal securities exchange
or trading market where such security is listed or traded as reported by Bloomberg, or if the foregoing do not apply, the last
closing bid price or last trade price, respectively, of such security in the over-the-counter market on the electronic bulletin
board for such security as reported by Bloomberg, or, if no closing bid price or last trade price, respectively, is reported for
such security by Bloomberg, the average of the bid prices, or the ask prices, respectively, of any market makers for such security
as reported in The Pink Open Market (or a similar organization or agency succeeding to its functions of reporting prices). If the
Closing Bid Price or the Closing Sale Price cannot be calculated for a security on a particular date on any of the foregoing bases,
the Closing Bid Price or the Closing Sale Price (as the case may be) of such security on such date shall be the fair market value as
mutually determined by the Company and the Required Holders. If the Company and the Required Holders are unable to agree upon the
fair market value of such security, then such dispute shall be resolved in accordance with the procedures in Section 27. All such
determinations shall be appropriately adjusted for any stock splits, stock dividends, stock combinations, recapitalizations or other
similar transactions during such period.
(q) “Closing
Date” shall have the meaning set forth in the Securities Purchase Agreement, which date is the date the Company initially issued
the Preferred Shares pursuant to the terms of the Securities Purchase Agreement.
(r)
“Code” means the Internal Revenue Code of 1986, as amended.
(s)
“Common Stock” means (i) the Company’s shares of common stock, $0.001 par value per share, and (ii)
any capital stock into which such common stock shall have been changed or any share capital resulting from a reclassification of
such common stock.
(t)
“Contingent Obligation” means, as to any Person, any direct or indirect liability, contingent or otherwise, of
that Person with respect to any Indebtedness, lease, dividend or other obligation of another Person if the primary purpose or intent
of the Person incurring such liability, or the primary effect thereof, is to provide assurance to the obligee of such liability that
such liability will be paid or discharged, or that any agreements relating thereto will be complied with, or that the holders of
such liability will be protected (in whole or in part) against loss with respect thereto.
(u)
“Conversion Floor Price Condition” means that the relevant Alternate Conversion Price is being determined based
on clause (x) of such definitions.
(v) “Convertible
Securities” means any stock or other security (other than Options) that is at any time and under any circumstances, directly
or indirectly, convertible into, exercisable or exchangeable for, or which otherwise entitles the holder thereof to acquire, any shares
of Common Stock.
(w)
“Eligible Market” means The New York Stock Exchange, the NYSE American, the Nasdaq Global Select Market, the
Nasdaq Global Market, the Nasdaq Capital Market.
(x)
“Excluded Securities” means (i) shares of Common Stock or standard options to purchase Common Stock issued to directors,
officers or employees of the Company for services rendered to the Company in their capacity as such pursuant to an Approved Stock Plan
(as defined above), provided that the exercise price of any such options is not lowered, none of such options are amended to increase
the number of shares issuable thereunder and none of the terms or conditions of any such options are otherwise materially changed in
any manner that adversely affects any of the Holders; (ii) shares of Common Stock issued upon the conversion or exercise, as applicable,
of Convertible Securities or Options (other than standard options to purchase Common Stock issued pursuant to an Approved Stock Plan
that are covered by clause (i) above) issued prior to the Subscription Date, provided that the conversion price or exercise price, as
applicable, of any such Convertible Securities or Options (other than standard options to purchase Common Stock issued pursuant to an
Approved Stock Plan that are covered by clause (i) above) is not lowered, none of such Convertible Securities or Options (other than
standard options to purchase Common Stock issued pursuant to an Approved Stock Plan that are covered by clause (i) above) are amended
to increase the number of shares issuable thereunder and none of the terms or conditions of any such Convertible Securities or Options
(other than standard options to purchase Common Stock issued pursuant to an Approved Stock Plan that are covered by clause (i) above)
are otherwise materially changed in any manner that adversely affects any of the Holders; (iii) the shares of Common Stock issuable upon
conversion of the Preferred Shares or otherwise pursuant to the terms of this Certificate of Designations; provided, that the terms of
this Certificate of Designations are not amended, modified or changed on or after the Subscription Date (other than antidilution adjustments
pursuant to the terms thereof in effect as of the Subscription Date); (iv) shares of Common Stock issued pursuant to a Permitted Equity
Line; and (v) the securities to be issued in the Business Combination in accordance with the terms of the Merger Agreement, as in effect
as of the Subscription Date.
(y)
“FATCA” means Sections 1471 through 1474 of the Code, as of the date of this Certificate of Designation (or any
amended or successor version that is substantively comparable and not materially more onerous to comply with), any current or future
regulations or official interpretations thereof, any agreements entered into pursuant to Section 1471(b)(1) of the Code and any
fiscal or regulatory legislation, rules or practices adopted pursuant to any intergovernmental agreement, treaty or convention among
Governmental Authorities and implementing such Sections of the Code.
(z)
“Floor Price” means $1.12 (as adjusted for stock splits, stock dividends, stock combinations, recapitalizations
and similar events), or, subject to the rules and regulations of the Principal Market, such lower price as the Company and the
Required Holders may agree, from time to time.
(aa)
“Fundamental Transaction” means (A) that the Company shall, directly or indirectly, including through
subsidiaries, Affiliates or otherwise, in one or more related transactions, (i) consolidate or merge with or into (whether or not
the Company is the surviving corporation) another Subject Entity, or (ii) sell, assign, transfer, convey or otherwise dispose of all
or substantially all of the properties or assets of the Company or any of its “significant subsidiaries” (as defined in
Rule 1-02 of Regulation S-X) to one or more Subject Entities, or (iii) make, or allow one or more Subject Entities to make, or allow
the Company to be subject to or have its Common Stock be subject to or party to one or more Subject Entities making, a purchase,
tender or exchange offer that is accepted by the holders of at least either (x) 50% of the outstanding shares of Common Stock, (y)
50% of the outstanding shares of Common Stock calculated as if any shares of Common Stock held by all Subject Entities making or
party to, or Affiliated with any Subject Entities making or party to, such purchase, tender or exchange offer were not outstanding;
or (z) such number of shares of Common Stock such that all Subject Entities making or party to, or Affiliated with any Subject
Entity making or party to, such purchase, tender or exchange offer, become collectively the beneficial owners (as defined in Rule
13d-3 under the 1934 Act) of at least 50% of the outstanding shares of Common Stock, or (iv) consummate a stock or share purchase
agreement or other business combination (including, without limitation, a reorganization, recapitalization, spin-off or scheme of
arrangement) with one or more Subject Entities whereby all such Subject Entities, individually or in the aggregate, acquire, either
(x) at least 50% of the outstanding shares of Common Stock, (y) at least 50% of the outstanding shares of Common Stock calculated as
if any shares of Common Stock held by all the Subject Entities making or party to, or Affiliated with any Subject Entity making or
party to, such stock purchase agreement or other business combination were not outstanding; or (z) such number of shares of Common
Stock such that the Subject Entities become collectively the beneficial owners (as defined in Rule 13d-3 under the 1934 Act) of at
least 50% of the outstanding shares of Common Stock, or (v) reorganize, recapitalize or reclassify its Common Stock, (B) that the
Company shall, directly or indirectly, including through subsidiaries, Affiliates or otherwise, in one or more related transactions,
allow any Subject Entity individually or the Subject Entities in the aggregate to be or become the “beneficial owner”
(as defined in Rule 13d-3 under the 1934 Act), directly or indirectly, whether through acquisition, purchase, assignment,
conveyance, tender, tender offer, exchange, reduction in outstanding shares of Common Stock, merger, consolidation, business
combination, reorganization, recapitalization, spin-off, scheme of arrangement, reorganization, recapitalization or reclassification
or otherwise in any manner whatsoever, of either (x) at least 50% of the aggregate ordinary voting power represented by issued and
outstanding Common Stock, (y) at least 50% of the aggregate ordinary voting power represented by issued and outstanding Common Stock
not held by all such Subject Entities as of the date of this Certificate of Designations calculated as if any shares of Common Stock
held by all such Subject Entities were not outstanding, or (z) a percentage of the aggregate ordinary voting power represented by
issued and outstanding shares of Common Stock or other equity securities of the Company sufficient to allow such Subject Entities to
effect a statutory short form merger or other transaction requiring other stockholders of the Company to surrender their shares of
Common Stock without approval of the stockholders of the Company or (C) directly or indirectly, including through subsidiaries,
Affiliates or otherwise, in one or more related transactions, the issuance of or the entering into any other instrument or
transaction structured in a manner to circumvent, or that circumvents, the intent of this definition in which case this definition
shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this definition to the extent
necessary to correct this definition or any portion of this definition which may be defective or inconsistent with the intended
treatment of such instrument or transaction.
(bb)
“GAAP” means United States generally accepted accounting principles, consistently applied.
(cc)
“Going Private Transaction” means any Change of Control (i) pursuant to which, the Company (and the Successor
Entity, if applicable) ceases to have any securities registered under the 1934 Act or (ii) that results in the purchase and/or
cancellation of all of the Common Stock of the Company solely for cash (and not in whole, or in part, for any other securities of
any Person).
(dd)
“Group” means a “group” as that term is used in Section 13(d) of the 1934 Act and as defined in Rule
13d-5 thereunder.
(ee)
“Governmental Authority” means any federal, foreign, state, county, municipal, provincial, or local governmental
authority, court, judicial body, arbitration tribunal, government or self-regulatory organization, commission, tribunal or
organization, or any regulatory, administrative, or other agency, or any political or other subdivision, department, commission,
board, bureau, branch, division, ministry, or instrumentality of any of the foregoing.
(ff)
“Indebtedness” means of any Person means, without duplication (A) all indebtedness for borrowed money, (B) all
obligations issued, undertaken or assumed as the deferred purchase price of property or services, including, without limitation,
“capital leases” in accordance with United States generally accepted accounting principles consistently applied for the
periods covered thereby (other than trade payables entered into in the ordinary course of business consistent with past practice),
(C) all reimbursement or payment obligations with respect to letters of credit, surety bonds and other similar instruments, (D) all
obligations evidenced by notes, bonds, debentures or similar instruments, including obligations so evidenced incurred in connection
with the acquisition of property, assets or businesses, (E) all indebtedness created or arising under any conditional sale or other
title retention agreement, or incurred as financing, in either case with respect to any property or assets acquired with the
proceeds of such indebtedness (even though the rights and remedies of the seller or bank under such agreement in the event of
default are limited to repossession or sale of such property), (F) all monetary obligations under any leasing or similar arrangement
which, in connection with United States generally accepted accounting principles, consistently applied for the periods covered
thereby, is classified as a capital lease, (G) all indebtedness referred to in clauses (A) through (F) above secured by (or for
which the holder of such Indebtedness has an existing right, contingent or otherwise, to be secured by) any mortgage, deed of trust,
lien, pledge, charge, security interest or other encumbrance of any nature whatsoever in or upon any property or assets (including
accounts and contract rights) with respect to any asset or property owned by any Person, even though the Person which owns such
assets or property has not assumed or become liable for the payment of such indebtedness, and (H) all Contingent Obligations in
respect of indebtedness or obligations of others of the kinds referred to in clauses (A) through (G) above.
(gg)
“Intellectual Property Rights” means, with respect to the Company and its Subsidiaries, all of their rights or
licenses to use all trademarks, trade names, service marks, service mark registrations, service names, original works of authorship,
patents, patent rights, copyrights, inventions, licenses, approvals, governmental authorizations, trade secrets and other
intellectual property rights and all applications and registrations therefor.
(hh)
“Liquidation Event” means, whether in a single transaction or series of transactions, the voluntary or
involuntary liquidation, dissolution or winding up of the Company or such Subsidiaries the assets of which constitute all or
substantially all of the assets of the business of the Company and its Subsidiaries, taken as a whole.
(ii) “Market
Price” means, with respect to any Adjustment Date, the Closing Bid Price of the Common Stock as of the Trading Day ended immediately
prior to such applicable Adjustment Date.
(jj)
“Material Adverse Effect” means any material adverse effect on the business, properties, assets, liabilities,
operations, results of operations, condition (financial or otherwise) or prospects of the Company and its Subsidiaries, if any,
individually or taken as a whole, or on the transactions contemplated hereby or on the other Transaction Documents (as defined
below), or by the agreements and instruments to be entered into in connection therewith or on the authority or ability of the
Company to perform its obligations under the Transaction Documents.
(kk)
“Options” means any rights, warrants or options to subscribe for or purchase shares of Common Stock or Convertible
Securities.
(ll)
“Parent Entity” of a Person means an entity that, directly or indirectly, controls the applicable Person and
whose common stock or equivalent equity security is quoted or listed on an Eligible Market, or, if there is more than one such
Person or Parent Entity, the Person or Parent Entity with the largest public market capitalization as of the date of consummation of
the Fundamental Transaction.
(mm)
“Person” means an individual, a limited liability company, a partnership, a joint venture, a corporation, a
trust, an unincorporated organization, any other entity or a government or any department or agency thereof.
(nn)
“Principal Market” means, as of any time of determination, the principal trading market, if any, in which the
shares of Common Stock then trade.
(oo) “Registration
Rights Agreement” means that certain registration rights agreement, dated as of the Closing Date, by and among the Company
and the initial holders of the Preferred Shares relating to, among other things, the registration of the resale of the Common Stock issuable
upon conversion of the Preferred Shares or otherwise pursuant to the terms of this Certificate of Designations, as may be amended from
time to time.
(pp)
“Required Premium” means as applicable (i) 150% with respect to an Alternate Conversion pursuant to clause
9(a)(xvii) above or (ii) otherwise, 125%.
(qq)
“SEC” means the United States Securities and Exchange Commission or the successor thereto.
(rr)
“Securities” shall have the meaning as set forth in the Securities Purchase Agreement.
(ss)
“Securities Purchase Agreement” means that certain securities purchase agreement by and among the Company and the
initial holders of Preferred Shares, dated as of the Subscription Date, as may be amended from time in accordance with the terms
thereof.
(tt)
“Series A Certificate of Designations” means the Certificate of Designations of the Company’s Series A
Convertible Preferred Stock, $0.0001 par value per share.
(uu)
“Stated Value” shall mean $1,000 per share, subject to adjustment for stock splits, stock dividends,
recapitalizations, reorganizations, reclassifications, combinations, subdivisions or other similar events occurring after the
Initial Issuance Date with respect to the Preferred Shares.
(vv)
“Subscription Date” means March 29, 2024.
(ww) “Subsequent
Placement” means any direct, or indirect, issuance, offer, sale, grant of any option or right to purchase, or otherwise
disposal of (or announcement of any issuance, offer, sale, grant of any option or right to purchase or other disposition of) any
equity security or any equity-linked or related security (including, without limitation, any “equity security” (as that
term is defined under Rule 405 promulgated under the 1933 Act), any Convertible Securities, any debt, any preferred stock or any
purchase rights) by the Company or any of its Subsidiaries.
(xx)
“Stock Combination Event” means the occurrence at any time and from time to time on or after the Subscription Date
of any stock split, stock dividend, stock combination recapitalization or other similar transaction involving the Common Stock.
(yy) “Subject
Entity” means any Person, Persons or Group or any Affiliate or associate of any such Person, Persons or Group.
(zz)
“Subsidiary” shall have the meaning set forth in the Securities Purchase Agreement.
(aaa)
“Successor Entity” means the Person (or, if so elected by the Required Holders, the Parent Entity) formed by,
resulting from or surviving any Fundamental Transaction or the Person (or, if so elected by the Required Holders, the Parent Entity)
with which such Fundamental Transaction shall have been entered into.
(bbb)
“Trading Day” means, as applicable, (x) with respect to all price or trading volume determinations relating to
the Common Stock, any day on which the Common Stock is traded on the Principal Market, or, if the Principal Market is not the
principal trading market for the Common Stock, then on the principal securities exchange or securities market on which the Common
Stock is then traded, provided that “Trading Day” shall not include any day on which the Common Stock is scheduled to
trade on such exchange or market for less than 4.5 hours or any day that the Common Stock is suspended from trading during the final
hour of trading on such exchange or market (or if such exchange or market does not designate in advance the closing time of trading
on such exchange or market, then during the hour ending at 4:00:00 p.m., New York time) unless such day is otherwise designated as a
Trading Day in writing by the applicable Holder or (y) with respect to all determinations other than price determinations relating
to the Common Stock, any day on which The New York Stock Exchange (or any successor thereto) is open for trading of
securities.
(ccc)
“Transaction Documents” means the Securities Purchase Agreement, the Registration Rights Agreement, this
Certificate of Designations and each of the other agreements and instruments entered into or delivered by the Company or any of the
Holders in connection with the transactions contemplated by the Securities Purchase Agreement, all as may be amended from time to
time in accordance with the terms thereof.
(ddd)
“VWAP” means, for any security as of any date, the dollar volume-weighted average price for such security on the
Principal Market (or, if the Principal Market is not the principal trading market for such security, then on the principal
securities exchange or securities market on which such security is then traded), during the period beginning at 9:30 a.m., New York
time, and ending at 4:00 p.m., New York time, as reported by Bloomberg through its “VAP” function (set to 09:30 start
time and 16:00 end time) or, if the foregoing does not apply, the dollar volume-weighted average price of such security in the
over-the-counter market on the electronic bulletin board for such security during the period beginning at 9:30 a.m., New York time,
and ending at 4:00 p.m., New York time, as reported by Bloomberg, or, if no dollar volume-weighted average price is reported for
such security by Bloomberg for such hours, the average of the highest closing bid price and the lowest closing ask price of any of
the market makers for such security as reported in The Pink Open Market (or a similar organization or agency succeeding to its
functions of reporting prices). If the VWAP cannot be calculated for such security on such date on any of the foregoing bases, the
VWAP of such security on such date shall be the fair market value as mutually determined by the Company and the Required Holders. If
the Company and the Required Holders are unable to agree upon the fair market value of such security, then such dispute shall be
resolved in accordance with the procedures in Section 27. All such determinations shall be appropriately adjusted for any stock
dividend, stock split, stock combination, recapitalization or other similar transaction during such period.
(eee)
“Warrants” has the meaning ascribed to such term in the Securities Purchase Agreement, and shall include all
warrants issued in exchange therefor or replacement thereof.
37. Disclosure.
Upon receipt or delivery by the Company of any notice in accordance with the terms of this Certificate of Designations, unless the Company
has in good faith determined that the matters relating to such notice do not constitute material, non-public information relating to
the Company or any of its Subsidiaries, the Company shall on or prior to 9:00 am, New York city time on the Business Day immediately
following such notice delivery date, publicly disclose such material, non-public information on a Current Report on Form 8-K or otherwise.
In the event that the Company believes that a notice contains material, non-public information relating to the Company or any of its
Subsidiaries, the Company so shall indicate to the applicable Holder explicitly in writing in such notice (or promptly (but no later
than the next Business Day) following receipt of notice from such Holder, as applicable), and in the absence of any such written indication
in such notice (or notification from the Company promptly (but no later than the next Business Day) following receipt of notice from
such Holder), such Holder shall be entitled to presume that information contained in the notice does not constitute material, non-public
information relating to the Company or any of its Subsidiaries. Nothing contained in this Section 37 shall limit any obligations of the
Company, or any rights of any Holder, under Section 4(i) of the Securities Purchase Agreement.
38. Absence
of Trading and Disclosure Restrictions. The Company acknowledges and agrees that no Holder is a fiduciary or agent of the Company
and that each Holder shall have no obligation to (a) maintain the confidentiality of any information provided by the Company or (b) refrain
from trading any securities while in possession of such information in the absence of a written non-disclosure agreement signed by an
officer of such Holder that explicitly provides for such confidentiality and trading restrictions. In the absence of such an executed,
written non-disclosure agreement, the Company acknowledges that each Holder may freely trade in any securities issued by the Company,
may possess and use any information provided by the Company in connection with such trading activity, and may disclose any such information
to any third party.
[The
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IN
WITNESS WHEREOF, the Company has caused this Certificate of Designations of the Certificate of Incorporation of CERo Therapeutics Holdings,
Inc. to be signed by its Chief Executive Officer on this 29th day of March, 2024.
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CERO THERAPEUTICS HOLDINGS, INC. |
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By: |
/s/ Charles Carter |
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Name: |
Charles Carter |
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Title: |
Chief Financial Officer |
EXHIBIT
I
CERO
THERAPEUTICS HOLDINGS, INC.
CONVERSION
NOTICE
Reference
is made to the Certificate of Designations of the Certificate of Incorporation of CERo Therapeutics Holdings, Inc., a Delaware corporation
(the “Company”) establishing the terms, preferences and rights of the Series B Convertible Preferred Stock, $0.001
par value (the “Preferred Shares”) of the Company (the “Certificate of Designations”). In accordance
with and pursuant to the Certificate of Designations, the undersigned hereby elects to convert the number of Preferred Shares indicated
below into shares of common stock, $0.001 value per share (the “Common Stock”), of the Company, as of the date specified
below.
Date
of Conversion: |
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Aggregate
number of Preferred Shares to be converted: |
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Aggregate
Stated Value of such Preferred Shares to be converted: |
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Aggregate
accrued and unpaid Dividends with respect to such Preferred Shares to be converted: |
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AGGREGATE
CONVERSION AMOUNT TO BE CONVERTED: |
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Please
confirm the following information: |
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Conversion
Price: |
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Number
of shares of Common Stock to be issued: |
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☐
If this Conversion Notice is being delivered with respect to an Alternate Conversion, check here if Holder is electing to use the
following Alternate Conversion Price:____________
Please
issue the Common Stock into which the applicable Preferred Shares are being converted to Holder, or for its benefit, as follows:
☐
Check here if requesting delivery as a certificate to the following name and to the following address:
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Issue
to: |
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☐
Check here if requesting delivery by Deposit/Withdrawal at Custodian as follows: |
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DTC
Participant: |
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DTC
Number: |
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Account
Number: |
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Date:
_____________ __,
Name
of Registered Holder |
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By: |
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Name: |
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Title: |
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Tax ID: |
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E-mail Address: |
EXHIBIT
II
ACKNOWLEDGMENT
The
Company hereby acknowledges this Conversion Notice, (b) certifies that the above indicated number of shares of Common Stock [are][are
not] eligible to be resold by the applicable Holder either (i) pursuant to Rule 144 (subject to such Holder’s execution and delivery
to the Company of a customary 144 representation letter) or (ii) an effective and available registration statement and (c) hereby directs
_________________ to issue the above indicated number of shares of Common Stock in accordance with the Transfer Agent Instructions dated
_____________, 20__ from the Company and acknowledged and agreed to by ________________________.
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CERO THERAPEUTICS HOLDINGS, INC. |
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By: |
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Name: |
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Title: |
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Exhibit 4.5
DESCRIPTION OF SECURITIES
The following summary of the material
terms of the securities of CERo Therapeutics Holdings, Inc. (f/k/a Phoenix Biotech Acquisition Corp.) (“we,”
“our” or “us”) is not intended to be a complete summary of the rights and preferences of such securities.
You are encouraged to read the applicable provisions of Delaware law, our second amended and restated certificate of incorporation
(the “Charter”), amended and restated bylaws (the “Bylaws”), the Certificate of Designation of Preferences,
Rights and Limitations of the Series A Convertible Preferred Stock (the “Series A Certificate of Designations”) and the Certificate of Designation of Preferences, Rights and Limitations of the Series B Convertible Preferred
Stock (the “Series B Certificate of Designations”) in their
entirety for a complete description of the rights and preferences of the securities.
General
We are authorized to issue up to 1,000,000,000 shares of Common
Stock, $0.0001 par value per share (“Common Stock”), and 10,000,000 shares of Preferred Stock, par value $0.0001 per
share (the “Preferred Stock”).
Preferred Stock
Our board of directors (the “Board”) is authorized to issue
“blank check” Preferred Stock, which may be issued in one or more series upon the authorization of the Board. The Board is
authorized to fix the designations, powers, preferences and the relative, participating, optional or other special rights and any qualifications,
limitations and restrictions of the shares of each series of Preferred Stock. The authorized shares of the Preferred Stock are available
for issuance without further action by our stockholders, unless such action is required by applicable law or the rules of any stock exchange
on which the securities may be listed. If the approval of our stockholders is not required for the issuance of shares of the Preferred
Stock, the Board may determine not to seek stockholder approval.
The Board will be able to, without stockholder approval, issue Preferred
Stock with voting and other rights that could adversely affect the voting power and other rights of the holders of the Common Stock and
could have anti-takeover effects. The ability of the Board to issue Preferred Stock without stockholder approval could have the effect
of delaying, deferring or preventing a change of control of us or the removal of existing management.
Series A Convertible Preferred Stock
We designated 12,580 shares of our
authorized and unissued Preferred Stock as Series A Convertible Preferred Stock (the “Series A Preferred Stock”) and
established the rights, preferences and privileges of the Series A Preferred Stock pursuant to the Series A Certificate of
Designations filed with the Secretary of State of the State of Delaware, as summarized below.
General. Each share of Series A Preferred
Stock has a stated value of $1,000 per share and, when issued, the Series A Preferred Stock was fully paid and non-assessable.
Ranking. The
Series A Preferred Stock, with respect to the payment of dividends, distributions and payments upon the liquidation, dissolution and
winding up of us, ranks senior to all capital stock of us unless the Required Holders (as defined in the Series A Certificate of
Designations) consent to the creation of other capital stock of us that is senior or equal in rank to the Series A Preferred
Stock.
Dividends. The holders of Series A Preferred
Stock will be entitled to dividends, on an as-if converted basis, equal to and in the same form as dividends actually paid on shares
of Common Stock, when and if actually paid.
Purchase
Rights. If at any time we grant, issue or sell any options, convertible securities, or rights to purchase
stock, warrants, securities or other property pro rata to all or substantially all of the record holders of any class of Common
Stock (the “Purchase Rights”), then each holder of Series A Preferred Stock will be entitled to acquire, upon the terms
applicable to such Purchase Rights, the aggregate Purchase Rights which such holder could have acquired if such holder had held the
number of shares of Common Stock acquirable upon complete conversion of all the Series A Preferred Stock held by such holder
immediately prior to the date as of which the record holders of shares of Common Stock are to be determined for the grant, issue or
sale of such Purchase Rights at the Alternate Conversion Price (as defined in the Series A Certificate of Designations); subject to
certain limitations on beneficial ownership.
Conversion Rights
Conversion at Option of Holder. Each
holder of Series A Preferred Stock may convert all, or any part, of the outstanding Series A Preferred Stock, at any time at such holder’s
option, into shares of the Common Stock (which converted shares of Common Stock are referred to as “Conversion Shares” herein)
at the fixed “Conversion Price” of $10.00, which is subject to proportional adjustment upon the occurrence of any stock split,
stock dividend, stock combination and/or similar transactions.
Voluntary Adjustment
Right. Subject to the rules and regulations of the Nasdaq, we have the right, at any time, with the
written consent of the Required Holders (as defined in the Series A Certificate of Designations), to lower the fixed conversion price to any amount and for any period of time deemed
appropriate by the Board.
Alternate Conversion Upon a Triggering Event. Following
the occurrence and during the continuance of a Triggering Event (as defined below), each holder may alternatively elect to convert the
Series A Preferred Stock at the “Alternate Conversion Price” equal to the lesser of:
| ● | the Conversion Price, and |
| ● | the floor price of $1.00; and |
| ● | 80% of the volume weighted average price of the Common Stock
during the 5 consecutive trading days immediately prior to such conversion. |
The Series A Certificate of Designations
contains standard and customary triggering events (each, a “Triggering Event”), including but not limited to: (i) the
suspension from trading or the failure to list the Common Stock within certain time periods; (ii) failure to declare or pay any
dividend when due; (iii) the failure to timely file or make effective a registration statement on Form S-1 pursuant to the
Registration Rights Agreement, dated as of February 14, 2024, by and between us and the holders of Series A Preferred Stock party
thereto (the “Registration Rights Agreement”), (iv) our failure to cure a conversion failure of failure to deliver
shares of the Common Stock under the Structuring Warrants (as defined below), or notice of our intention not to comply with a
request for conversion of any Series A Preferred Stock or a request for exercise of any Structuring Warrants, and (iv) bankruptcy or
insolvency of us.
Other
Adjustments. If 90 days or 180 days following the occurrence of the later of (x) the Stockholder Approval
Date (as defined below) and (y) the earlier of (a) the effective date of the registration statement to be filed pursuant to the
Registration Rights Agreement and (b) the date that the Series A Preferred Stock is eligible to be resold without restriction under
Rule 144 of the Securities Act of 1933, as amended (the “Securities Act”), the Conversion Price then in effect is
greater than the greater of $1.00 and the Market Price (as defined in the Series A Certificate of Designations) then in effect (the
“Adjustment Price”), the Conversion Price shall automatically lower to the Adjustment Price.
Limitations on Conversion. In no event
shall the Series A Preferred Stock be convertible into a number of shares of New Common Stock exceeding 19.99% of the total number
of shares of Common Stock outstanding immediately prior to the execution of the Securities Purchase Agreement, except that such limitation
shall not apply in the event that we obtain approval from our stockholders for the issuance of such shares in accordance with the applicable
stock exchange rules (the date of such approval, the “Stockholder Approval Date”).
Bankruptcy Triggering Event Redemption Right. Upon
any bankruptcy Triggering Event, we shall immediately redeem in cash all amounts due under the Series A Preferred Stock at 25% premium
(or, if 18 months following the issuance date, 50% premium) to the greater of (x) the amount of shares of Series A Preferred Stock
then outstanding and (y) the equity value of the shares of Series A Preferred Stock then outstanding, unless the holder waives such right
to receive such payment. The equity value of the Common Stock underlying the Series A Preferred Stock is calculated using the greatest
closing sale price of the Common Stock on any trading day immediately preceding such bankruptcy Triggering Event and the date we make
the entire payment required.
Change of Control Exchange. Upon
a change of control of the Company, each holder may require us to exchange the holder’s shares of Series A Preferred Stock for
consideration equal to the change of Control Election Price (as defined in the Series A Certificate of Designations), to be satisfied
at our election in either (x) cash or (y) rights convertible into such securities or other assets to which such holder would have been
entitled with respect to such shares of Common Stock had such shares of Common Stock been held by such holder upon consummation of such
corporate event.
Company Optional Redemption. At any time
we shall have the right to redeem in cash all, but not less than all, the shares of Series A Preferred Stock then outstanding at
a 20% redemption premium to the greater of (x) the amount of shares being redeemed, and (y) the equity value of the Common Stock
underlying the Series A Preferred Stock. The equity value of the Common Stock underlying the Series A Preferred Stock is calculated
using the greatest closing sale price of the Common Stock on any trading day immediately preceding the date we notify the holders
of our election to redeem and the date we make the entire payment required.
Fundamental
Transactions. The Series A Certificate of Designations prohibit us from entering specified fundamental
transactions (including, without limitation, mergers, business combinations and similar transactions) unless we (or our successor)
assumes in writing all of our obligations under the Series A Certificate of Designations and the other Transaction Documents (as
defined in the Series A Certificate of Designations).
Voting
Rights. The holders of the Series A Preferred Stock shall have no voting power and no right to vote on
any matter at any time, either as a separate series or class or together with any other series or class of share of capital stock,
and shall not be entitled to call a meeting of such holders for any purpose nor shall they be entitled to participate in any meeting
of the holders of Common Stock, except as provided in the Series A Certificate of Designations (or as otherwise required by
applicable law).
Covenants. The
Series A Certificate of Designations contains a variety of obligations on our part not to engage in specified activities, which are
typical for transactions of this type. In particular, we will not, and will cause our subsidiaries to not, redeem, repurchase or
declare any dividend or distribution on any of our capital stock (other than as required under the Series A Certificate of
Designations). In addition, we will not issue any preferred stock or issue any other securities that would cause a breach or default
under the Series A Certificate of Designations or Structuring Warrants.
Reservation Requirements. So long as
any Series A Preferred Stock remains outstanding, we shall at all times reserve at least 150% of the number of shares of Common Stock
as shall from time to time be necessary to effect the conversion of all Series A Preferred Stock then outstanding.
Series B Convertible Preferred Stock
We designated 626 shares of our authorized and unissued Preferred Stock
as Series B Convertible Preferred Stock (the “Series B Preferred Stock”) and established the rights, preferences and privileges
of the Series B Preferred Stock pursuant to the Series B Certificate of Designations filed with the Secretary of State of the State of
Delaware, as summarized below. Except as set forth below, the Series B Preferred Stock has terms and provisions that are identical to
those of the Series A Preferred Stock.
Ranking. The Series
B Preferred Stock, with respect to the payment of dividends, distributions and payments upon the liquidation, dissolution and winding
up of us, ranks senior to all capital stock of us unless the Required Holders (as defined in the Series B Certificate of Designations)
or the requisite holders of the outstanding shares of the Series A Preferred Stock (the “Series A Requisite Holders”) consent
to the creation of other capital stock of us that is senior or equal in rank to the Series B Preferred Stock. The Series B Preferred Stock
ranks pari passu with the Series A Preferred Stock.
Covenants. The
Series B Certificate of Designations contains a variety of obligations on our part not to engage in specified activities, which are typical
for transactions of this type. In particular, we will not, and will cause our subsidiaries to not, redeem, repurchase or declare any
dividend or distribution on any of our capital stock (other than as required under the Series B Certificate of Designations). In addition,
we will not issue any preferred stock or issue any other securities that would cause a breach or default under the Series B Certificate
of Designations. Any waiver or amendment of the foregoing covenants by the Series A Requisite Holders shall be deemed to be a waiver
or amendment by the Required Holders (as defined in the Series B Certificate of Designations) under the Series B Certificate of Designations.
Common Stock
Voting
Each holder of Common Stock is entitled to one vote for each share
on all matters submitted to a vote of the stockholders, including the election of directors, with the exception of certain matters relating
solely to the terms of one or more outstanding series of preferred stock. Under the Charter, our stockholders do not have cumulative voting
rights. Because of this, the holders of a majority of the shares of Common Stock entitled to vote in any election of directors can elect
all of the directors standing for election.
Dividends
Subject to preferences that may apply to any then-outstanding Preferred
Stock, the holders of Common Stock are entitled to receive ratably those dividends, if any, as may be declared from time to time by the
Board out of legally available funds.
Liquidation
In the event of our liquidation, dissolution or winding up, holders
of Common Stock will be entitled to share ratably in the net assets legally available for distribution to stockholders after the payment
of all of our debts and other liabilities and the satisfaction of any liquidation preference granted to the holders of any then-outstanding shares
of Preferred Stock.
Preemptive or Similar Rights
Holders of Common Stock have no preemptive, conversion or subscription
rights and there are no redemption or sinking fund provisions applicable to the Common Stock. The rights, preferences and privileges of
the holders of Common Stock are subject to, and may be adversely affected by, the rights of the holders of shares of any series of Preferred
Stock that we may designate in the future.
Warrants
The outstanding warrants consist of (i) warrants initially issued in
connection with our initial public offering (the “Public Warrants”), (ii) warrants initially sold in a private placement concurrently
with our initial public offering (the “Private Placement Warrants”), (iii) warrants initially issued by CERo Therapeutics,
Inc. and converted into warrants to purchase Common Stock in connection with our initial business combination (the “Conversion Warrants”)
and (iv) warrants to purchase Common Stock sold in a private placement concurrently with our initial business combination (the “Common
Warrants”) and (v) warrants to purchase Series A Preferred Stock sold in a private placement concurrently with our business combination
(the “Preferred Warrants” and, together with the Public Warrants, the Private Placement Warrants, the Conversion Warrants
and the Common Warrants, the “Warrants”).
Public Warrants
General. Each Public Warrant entitles
the registered holder to purchase one share of Common Stock at a price of $11.50 per share, subject to adjustment as discussed below,
commencing 30 days after the completion of the initial business combination. The Public Warrants are governed by the terms of a Warrant
Agreement, dated as of October 5, 2021 between us and Continental Stock Transfer & Trust Company, as warrant agent (the “Warrant
Agreement”). Pursuant to the Warrant Agreement, a warrant holder may exercise its Public Warrants only for a whole number of shares
of Common Stock. This means that only a whole Public Warrant may be exercised at any given time by a warrant holder. No fractional Public
Warrants will be issued and only whole Public Warrants will trade. The Public Warrants will expire five years after the completion
of the initial business combination, at 5:00 p.m., New York City time, or earlier upon redemption or liquidation.
Registration of Public Warrants. We
will not be obligated to deliver any shares of Common Stock pursuant to the exercise for cash of a Public Warrant and will have no obligation
to settle such warrant exercise unless a registration statement under the Securities Act with respect to the shares of Common
Stock underlying the Public Warrants is then effective and a prospectus relating thereto is current, subject to our satisfying our obligations
described below with respect to registration. No Public Warrant will be exercisable and we will not be obligated to issue shares of Common
Stock upon exercise of a Public Warrant unless Common Stock issuable upon such warrant exercise has been registered, qualified or deemed
to be exempt from the registration or qualifications requirements of the securities laws of the state of residence of the registered
holder of the Public Warrants. Notwithstanding the foregoing, if a registration statement covering the shares of Common Stock issuable
upon exercise of the Public Warrants has not been declared effective by the end of 60 business days following the closing of the
initial business combination, warrantholders may, until such time as there is an effective registration statement and during any period
when we shall have failed to maintain an effective registration statement, exercise Public Warrants on a cashless basis pursuant to the
exemption provided by Section 3(a)(9) of the Securities Act.
We have agreed that as soon as practicable, but in no event later than
20 business days after the closing of the initial business combination, we will use our best efforts to file with the SEC, and within
60 business days following the initial business combination to have declared effective, a registration statement covering the issuance
of the shares of Common Stock issuable upon exercise of the Public Warrants and to maintain a current prospectus relating to those shares
of Common Stock until the Public Warrants expire or are redeemed, as specified in the Warrant Agreement. If a registration statement covering
the shares of Common Stock issuable upon exercise of the Public Warrants is not effective by the 60th business day
after the closing of the initial business combination, warrantholders may, until such time as there is an effective registration statement
and during any period when we will have failed to maintain an effective registration statement, exercise Public Warrants on a “cashless
basis” in accordance with Section 3(a)(9) of the Securities Act or another exemption. In addition to the above,
if Common Stock is at the time of any exercise of a Public Warrant not listed on a national securities exchange such that it satisfies
the definition of a “covered security” under Section 18(b)(1) of the Securities Act, we may, at our option,
require holders of Public Warrants who exercise their Public Warrants to do so on a “cashless basis” in accordance with Section 3(a)(9) of
the Securities Act and, in the event we so elects, we will not be required to file or maintain in effect a registration statement,
and in the event it does not so elect, it will use our best efforts to register or qualify the shares under applicable blue sky laws to
the extent an exemption is not available.
Redemption of Warrants. Once the Public Warrants become exercisable,
we may call the Public Warrants for redemption:
| ● | in whole and not in part; |
| ● | at a price of $0.01 per warrant; |
| ● | upon not less than 30 days’ prior written notice
of redemption (the “30-day redemption period”) to each warrant holder; and |
| ● | if, and only if, the reported last sale price of the Common
Stock (or the closing bid price of our common stock in the event shares of Common Stock are not traded on any specific day) equals
or exceeds $18.00 per share (as adjusted for stock splits, stock dividends, reorganizations, recapitalizations and the like) for any
20 trading days within a 30 trading day period ending three business days before we send the notice of redemption to the
warrantholders. |
If and when the Public Warrants become redeemable by us, it may exercise
its redemption right even if it is unable to register or qualify the underlying securities for sale under all applicable state securities
laws.
We have established the last of the redemption criterion discussed
above to prevent a redemption call unless there is at the time of the call a significant premium to the warrant exercise price. If the
foregoing conditions are satisfied and we issue a notice of redemption of the Public Warrants, each warrant holder will be entitled to
exercise its warrant prior to the scheduled redemption date. However, the price of the Common Stock may fall below the $18.00 redemption
trigger price (as adjusted for stock splits, stock dividends, reorganizations, recapitalizations and the like) as well as the $11.50 (for
whole shares) warrant exercise price after the redemption notice is issued.
Cashless Exercise. If we call the
Public Warrants for redemption as described above, our management will have the option to require any holder that wishes to exercise
its Public Warrant to do so on a “cashless basis.” In determining whether to require all holders to exercise their Public
Warrants on a “cashless basis,” Our management will consider, among other factors, our cash position, the number of Public
Warrants that are outstanding and the dilutive effect on our stockholders of issuing the maximum number of shares of Common Stock issuable
upon the exercise of our warrants. If our management takes advantage of this option, all holders of Public Warrants would pay the exercise
price by surrendering their warrants for that number of shares of Common Stock equal to the quotient obtained by dividing (x) the
product of the number of shares of Common Stock underlying the Public Warrants, multiplied by the difference between the exercise price
of the Public Warrants and the “fair market value” (defined below) by (y) the fair market value. The “fair market
value” shall mean the average reported last sale price of the Common Stock for the 10 trading days ending on the third trading
day prior to the date on which the notice of redemption is sent to the holders of Public Warrants. If our management takes advantage
of this option, the notice of redemption will contain the information necessary to calculate the number of shares of Common Stock to
be received upon exercise of the Public Warrants, including the “fair market value” in such case. Requiring a cashless exercise
in this manner will reduce the number of shares to be issued and thereby lessen the dilutive effect of a warrant redemption.
A holder of a Public Warrant may notify us in writing in the event
it elects to be subject to a requirement that such holder will not have the right to exercise such warrant, to the extent that after giving
effect to such exercise, such person (together with such person’s affiliates), to the warrant agent’s actual knowledge, would
beneficially own in excess 9.8% (or such other amount as a holder may specify) of the shares of Common Stock outstanding immediately after
giving effect to such exercise.
Anti-Dilution Adjustments. If the number
of outstanding shares of Common Stock is increased by a stock dividend payable in shares of Common Stock, or by a split-up of shares
of Common Stock or other similar event, then, on the effective date of such stock dividend, split-up or similar event, the number
of shares of Common Stock issuable on exercise of each warrant will be increased in proportion to such increase in the outstanding shares
of Common Stock. A rights offering to holders of Common Stock entitling holders to purchase shares of Common Stock at a price less than
the fair market value will be deemed a stock dividend of a number of shares of Common Stock equal to the product of (i) the number
of shares of Common Stock actually sold in such rights offering (or issuable under any other equity securities sold in such rights offering
that are convertible into or exercisable for Common Stock) multiplied by (ii) one (1) minus the quotient of (x) the price
per share of Common Stock paid in such rights offering divided by (y) the fair market value. For these purposes (i) if the rights
offering is for securities convertible into or exercisable for Common Stock, in determining the price payable for Common Stock, there
will be taken into account any consideration received for such rights, as well as any additional amount payable upon exercise or conversion
and (ii) fair market value means the volume weighted average price of Common Stock as reported during the 10 trading day period
ending on the trading day prior to the first date on which the shares of Common Stock trade on the applicable exchange or in the
applicable market, regular way, without the right to receive such rights.
In addition, if we, at any time while the Public Warrants are outstanding
and unexpired, pay a dividend or makes a distribution in cash, securities or other assets to the holders of Common Stock on account of
such shares of Common Stock (or other shares of our capital stock into which the Public Warrants are convertible), other than (a) as
described above or (b) any cash dividends or cash distributions which, when combined on a per share basis with all other cash dividends
and cash distributions paid on the shares of Common Stock during the 365-day period ending on the date of declaration of such dividend
or distribution does not exceed $0.50 (as adjusted to appropriately reflect any other adjustments and excluding cash dividends or cash
distributions that resulted in an adjustment to the exercise price or to the number of shares of Common Stock issuable on exercise of
each warrant) but only with respect to the amount of the aggregate cash dividends or cash distributions equal to or less than $0.50 per
share.
If the number of outstanding shares of Common Stock is decreased by
a consolidation, combination, reverse stock split or reclassification of shares of Common Stock or other similar event, then, on the effective
date of such consolidation, combination, reverse stock split, reclassification or similar event, the number of shares of Common Stock
issuable on exercise of each Public Warrant will be decreased in proportion to such decrease in outstanding shares of Common Stock.
Whenever the number of shares of Common Stock purchasable upon the
exercise of the Public Warrants is adjusted, as described above, the warrant exercise price will be adjusted by multiplying the warrant
exercise price immediately prior to such adjustment b a fraction (x) the numerator of which will be the number of shares of Common Stock
purchasable upon the exercise of the Public Warrants immediately prior to such adjustment, and (y) the denominator of which will be the
number of shares of Common Stock to purchase immediately thereafter.
In case of any reclassification or
reorganization of the issued and outstanding shares of Common Stock (other than those described above or that solely affects the par
value of such shares of Common Stock), or in the case of any merger or consolidation of us with or into another entity (other than a
consolidation or merger in which we are the continuing corporation and that does not result in any reclassification or
reorganization of our issued and outstanding shares of Common Stock) in which any “person” or “group” (as
such terms are used in Sections 13(d) and 14(d) of the Exchange Act) acquired more than 50% of the voting power of our securities in
a transaction that results in a Change of Control Transaction (as defined in the Warrant Agreement), or in the case of any sale or
conveyance to another corporation or entity of the assets or other property of us as an entirety or substantially as an entirety,
the holders of Public Warrants will thereafter have the right to purchase and receive, upon the basis and upon the terms and
conditions specified in the Public Warrants and in lieu of shares of Common Stock immediately theretofore purchasable and receivable
upon the exercise of the rights represented thereby, the kind and amount of shares of Common Stock or other securities or property
(including cash) receivable upon such reclassification, reorganization, merger or consolidation, or upon a dissolution following any
such sale or transfer, that the holder of the Public Warrants would have received if such holder had exercised their Public Warrants
immediately prior to such event. However, if such holders were entitled to exercise a right of election as to the kind or amount of
securities, cash or other assets receivable upon such consolidation or merger, then the kind and amount of securities, cash or other
assets for which each Public Warrant will become exercisable will be deemed to be the weighted average of the kind and amount
received per share by such holders in such consolidation or merger that affirmatively make such election. If less than 70% of the
consideration receivable by the holders of Common Stock in such a transaction is payable in the form of Common Stock in the
successor entity that is listed for trading on a national securities exchange or is quoted in an established over-the-counter
market, or is to be so listed for trading or quoted immediately following such event, and if the registered holder of the Public
Warrant properly exercises the Public Warrant within thirty days following public disclosure of such transaction pursuant to a
Current Report on Form 8-K, the warrant exercise price will be reduced as specified in the Warrant Agreement based on the
Black-Scholes value (as defined in the Warrant Agreement) of the Public Warrant. The purpose of such exercise price reduction is to
provide additional value to holders of the Public Warrants when an extraordinary transaction occurs during the exercise period of
the Public Warrants pursuant to which the holders of the Public Warrants otherwise do not receive the full potential value of the
Public Warrants.
The Public Warrant may be exercised upon surrender of the warrant certificate
on or prior to the expiration date at the offices of the warrant agent, with the exercise form on the reverse side of the warrant certificate
completed and executed as indicated, accompanied by full payment of the exercise price (or on a cashless basis, if applicable), by certified
or official bank check payable to us, for the number of Public Warrants being exercised. The warrant holders do not have the rights or
privileges of holders of Common Stock and any voting rights until they exercise their Public Warrants and receive shares of Common Stock.
After the issuance of shares of Common Stock upon exercise of the Public Warrants, each holder will be entitled to one vote for each share
held of record on all matters to be voted on by stockholders.
Public Warrants may be exercised only for a whole number of shares
of Common Stock. No fractional shares will be issued upon exercise of the Public Warrants. If, upon exercise of the Public Warrants, a
holder would be entitled to receive a fractional interest in a share, we will, upon exercise, round down to the nearest whole number of
shares of Common Stock to be issued to the warrant holder. As a result, warrant holders not purchasing an even number of Public Warrants
must sell any odd number of Public Warrants in order to obtain full value from the fractional interest that will not be issued.
The Public Warrants were issued in registered form under the Warrant
Agreement. You should review a copy of the Warrant Agreement, which is filed as an exhibit to our registration statement on Form S-4 filed
on June 7, 2023, for a complete description of the terms and conditions applicable to the Public Warrants. The Warrant Agreement provides
that the terms of the Public Warrants may be amended without the consent of any holder to cure any ambiguity or correct any defective
provision, but requires the approval by the holders of a majority of the then-outstanding Public Warrants to make any changes that adversely
affect the interests of the registered holders of Public Warrants.
Private Placement Warrants
The Private Placement Warrants (including
the Common Stock issuable upon exercise of the Private Placement Warrants) are not transferable, assignable or salable until
30 days after the completion of our business combination (subject to limited exceptions). In addition, for as long as Private
Placement Warrants are held by Cantor Fitzgerald & Co. and/or its designees or affiliates, such Private Placement Warrants will
be subject to a lock-up in compliance with FINRA Rule 5110(e) and may not be exercised after five years from the
commencement of sales of our initial public offering in accordance with FINRA Rule 5110(g)(8)(A). The Private Placement
Warrants will be redeemable by us and exercisable by the holders on the same basis as the Public Warrants.
Conversion Warrants
Exercise Price. The Conversion Warrants
will initially be exercisable for cash at an exercise price equal to $10.00. The exercise price is subject to adjustment for stock
splits, combinations and similar events, and, in the event of stock dividends and splits, the number of shares of Common Stock issuable
upon the exercise of the Conversion Warrant will also be adjusted so that the aggregate exercise price shall be the same immediately before
and immediately after any such adjustment.
Exercise Period. The Conversion Warrants
will expire five years after their issuance, or November 14, 2024.
Automatic Conversion. The Conversion
Warrants will automatically convert at the end of the exercise period if the fair market value (as determined in the Conversion Warrants)
of a share of Common Stock underlying the Conversion Warrants is greater than the exercise price in effect on such date.
Common Warrants
Exercise Price. The Common Warrants will
initially be exercisable for cash at an exercise price equal to the greater of (x) $9.20 (as adjusted for stock splits, stock dividends,
stock combinations, recapitalizations and similar events) and (y) the closing price of the Common Stock on the trading day immediately
prior to the Subscription Date (as defined in the Common Warrant). The exercise price is subject to adjustment for stock splits, combinations
and similar events, and, in the event of stock dividends and splits, the number of shares of Common Stock issuable upon the exercise of
the Common Warrant will also be adjusted so that the aggregate exercise price shall be the same immediately before and immediately after
any such adjustment.
Exercise Period. The Common Warrants
will be exercisable beginning six months after the consummation of the issuance date (the “Initial Exercisability Date”) and
expiring on the third anniversary of the Initial Exercisability Date. The Common Warrants require “buy-in” payments to be
made by us for failure to deliver any shares of Common Stock issuable upon exercise.
Cashless Exercise. If at the time of
exercise of the Common Warrants, there is no effective registration statement registering the shares of the Common Stock underlying the
Common Warrants, such warrants may be exercised on a cashless basis pursuant to their terms.
Purchase Rights; Participation Rights. If
we issue options, convertible securities, warrants, shares, or similar securities to holders of Common Stock, each holder of Common Warrants
has the right to acquire the same as if the holder had exercised its Common Warrant. The holders of Common Warrants are entitled to receive
any dividends paid or distributions made to our holders of Common Stock on an “as if converted” basis.
Fundamental Transactions. The Common
Warrants prohibit us from entering into specified fundamental transactions unless the successor entity assumes all of our obligations
under the Common Warrants under a written agreement before the transaction is completed. Upon specified corporate events, a holder of
Common Warrants will thereafter have the right to receive upon an exercise such shares, securities, cash, assets or any other property
whatsoever which the holder would have been entitled to receive upon the happening of the applicable corporate event had the Common Warrant
been exercised immediately prior to the applicable corporate event. When there is a transaction involving specified changes of control,
a holder of Common Warrants will have the right to force us to repurchase the holder’s Common Warrant for a purchase price in cash
equal to the Black-Scholes value, as calculated under the Common Warrants, of the then unexercised portion of the Common Warrant.
Preferred Warrants
Exercise Price. The Preferred Warrants
will initially be exercisable for cash at an exercise price equal to $1,000. The exercise price is subject to adjustment for stock splits,
combinations and similar events, and, in the event of stock dividends and splits, the number of shares of Series A Preferred Stock issuable
upon the exercise of the Preferred Warrant will also be adjusted so that the aggregate exercise price shall be the same immediately before
and immediately after any such adjustment.
Exercise Period. The Preferred Warrants
will expire on the first anniversary of the closing of the initial business combination, or February 14, 2025.
Forced Exercise. We have the right to
require the holders of Preferred Warrants to exercise such Preferred Warrants into up to an aggregate number of shares of Preferred Stock
equal to the holder’s pro rata amount of 2,000 Preferred Shares.
Fundamental Transactions. The Preferred
Warrants prohibit us from entering into specified fundamental transactions unless the successor entity assumes all of our obligations
under the Preferred Warrants under a written agreement before the transaction is completed. Upon specified corporate events, a holder
of Preferred Warrants will thereafter have the right to receive upon an exercise such shares, securities, cash, assets or any other property
whatsoever which the holder would have been entitled to receive upon the happening of the applicable corporate event had the Preferred
Warrant been exercised immediately prior to the applicable corporate event.
Anti-Takeover Provisions
Section 203 of the Delaware General
Corporation Law
We are subject to Section 203 of the
DGCL, which generally prohibits a publicly held Delaware corporation from engaging in any business combination with any interested stockholder
for a period of three years after the date that such stockholder became an interested stockholder, with the following exceptions:
| ● | before such date, the board of directors of the corporation approved either the business combination
or the transaction that resulted in the stockholder becoming an interested stockholder; |
|
● |
upon completion of the transaction that resulted in the stockholder becoming an interested stockholder, the interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction began, excluding for purposes of determining the voting stock outstanding, but not the outstanding voting stock owned by the interested stockholder, those shares owned (1) by persons who are directors and also officers and (2) employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to the plan will be tendered in a tender or exchange offer; or |
|
● |
on or after such date, the business combination is approved by the board of directors and authorized at an annual or special meeting of the stockholders, and not by written consent, by the affirmative vote of at least 662/3% of the outstanding voting stock that is not owned by the interested stockholder. |
In general,
Section 203 defines a “business combination” to include the following:
|
● |
any merger or consolidation involving the corporation and the interested stockholder; |
|
● |
any sale, transfer, pledge or other disposition of 10% or more of the assets of the corporation involving the interested stockholder; |
|
● |
subject to certain exceptions, any transaction that results in the issuance or transfer by the corporation of any stock of the corporation to the interested stockholder; |
|
● |
any transaction involving the corporation that has the effect of increasing the proportionate share of the stock or any class or series of the corporation beneficially owned by the interested stockholder; or |
|
● |
the receipt by the interested stockholder of the benefit of any loans, advances, guarantees, pledges or other financial benefits by or through the corporation. |
|
● |
In general, Section 203 defines an “interested stockholder” as an entity or person who, together with the person’s affiliates and associates, beneficially owns or, within three years prior to the time of determination of interested stockholder status, did own 15% or more of the outstanding voting stock of the corporation. |
|
● |
A Delaware corporation may “opt out” of these provisions with an express provision in its original certificate of incorporation or an express provision in its amended and restated certificate of incorporation or amended and restated bylaws resulting from a stockholders’ amendment approved by at least a majority of the outstanding voting shares. We have not opted out of these provisions. As a result, mergers or other takeover or change in control attempts of we may be discouraged or prevented. |
In general, Section 203 defines an “interested
stockholder” as an entity or person who, together with the person’s affiliates and associates, beneficially owns or, within
three years prior to the time of determination of interested stockholder status, did own 15% or more of the outstanding voting stock of
the corporation.
A Delaware corporation may “opt out”
of these provisions with an express provision in its original certificate of incorporation or an express provision in its amended and
restated certificate of incorporation or amended and restated bylaws resulting from a stockholders’ amendment approved by at least
a majority of the outstanding voting shares. We have not opted out of these provisions. As a result, mergers or other takeover or change
in control attempts of us may be discouraged or prevented.
Among other things, the Charter and Bylaws:
| ● | permit the Board to issue up to 10,000,000 shares of Preferred
Stock, with any rights, preferences and privileges as they may designate, including the right to approve an acquisition or other change
of control; |
| ● | provide that the authorized number of directors may be fixed
only by resolution of the Board; |
| ● | provide that the Board will be classified into three classes
of directors; |
| ● | provide that, subject to the rights of any series of Preferred
Stock to elect directors, directors may only be removed for cause, which removal may be effected, subject to any limitation imposed by
law, by the holders of at least 66 2/3% of the voting power of all of our then-outstanding shares of the capital stock entitled
to vote generally at an election of directors, voting together as a single class; |
| ● | provide that all vacancies, including newly created directorships,
may, except as otherwise required by law, be filled by the affirmative vote of a majority of directors then in office, even if less than
a quorum; |
| ● | require that any action to be taken by our stockholders must
be effected at a duly called annual or special meeting of stockholders and not be taken by written consent or electronic transmission; |
| ● | provide that our stockholders seeking to present proposals before
a meeting of stockholders or to nominate candidates for election as directors at a meeting of stockholders must provide advance notice
in writing, and also specify requirements as to the form and content of a stockholder’s notice; |
| ● | provide that special meetings of our stockholders may be called
only by the chairperson of the Board, our chief executive officer or by the Board pursuant to a resolution adopted by a majority of the
total number of authorized directors; and |
| ● | not provide for cumulative voting rights, therefore allowing
the holders of a majority of the shares of Common Stock entitled to vote in any election of directors to elect all of the directors standing
for election if they should so choose. |
The amendment of a number of these provisions would require approval
by the holders of at least 66 2/3% of the voting power of all of our then-outstanding capital stock entitled to vote generally in
the election of directors, voting together as a single class.
The combination of these provisions will make it more difficult for
our existing stockholders to replace the Board, as well as for another party to obtain control of us by replacing the Board. Since the
Board has the power to retain and discharge our officers, these provisions could also make it more difficult for existing stockholders
or another party to effect a change in management. In addition, the authorization of undesignated preferred stock makes it possible for
the Board to issue preferred stock with voting or other rights or preferences that could impede the success of any attempt to change our
control.
These provisions are intended to enhance the likelihood of continued
stability in the composition of our Board and our policies and to discourage coercive takeover practices and inadequate takeover bids.
These provisions are also designed to reduce our vulnerability to hostile takeovers and to discourage certain tactics that may be used
in proxy fights. However, such provisions could have the effect of discouraging others from making tender offers for our shares and may
have the effect of delaying changes in our control or management. As a consequence, these provisions may also inhibit fluctuations in
the market price of our stock.
Choice of Forum
The Charter and Bylaws provide that, unless we consents in writing
to the selection of an alternative forum, the Court of Chancery of the State of Delaware (or, if the Court of Chancery of the State of
Delaware lacks subject matter jurisdiction, any state court located within the State of Delaware or, if all such state courts lack subject
matter jurisdiction, the federal district court for the District of Delaware) and any appellate court therefrom will be the sole and exclusive
forum for the following claims or causes of action under Delaware statutory or common law: (A) any derivative claim or cause of action
brought on our behalf, (B) any claim or cause of action for breach of a fiduciary duty owed by any of our then current or former
directors, officers, or other employees to us or our stockholders, (C) any claim or cause of action against it or any of our current
or former directors, officers or other employees arising out of or pursuant to any provision of the DGCL, the Charter or the Bylaws (as
each may be amended from time to time), (D) any claim or cause of action seeking to interpret, apply, enforce or determine the validity
of the Charter or Bylaws (as each may be amended from time to time, including any right, obligation, or remedy thereunder) (E) any
claim or cause of action as to which the DGCL confers jurisdiction on the Court of Chancery of the State of Delaware or (F) any claim
or cause of action against us or any of our then current or former directors, officers or other employees, governed by the internal-affairs doctrine
or otherwise related to our internal affairs, in each case to the fullest extent permitted by law and subject to the court having personal
jurisdiction over the indispensable parties named as defendants. These provisions do not apply to claims or causes of action brought to
enforce a liability or duty created by the Securities Act, the Exchange Act or any other claim where the U.S. federal courts
have exclusive jurisdiction. Furthermore, Section 22 of the Securities Act creates concurrent jurisdiction for federal
and state courts over all such Securities Act actions. Accordingly, both state and federal courts have jurisdiction to entertain
such claims. To prevent having to litigate claims in multiple jurisdictions and the threat of inconsistent or contrary rulings by different
courts, among other considerations, the Charter and Bylaws will further provide that, unless we consent in writing to the selection of
an alternative forum, to the fullest extent permitted by law, the federal district courts of the United States will be the exclusive
forum for the resolution of any action or proceeding asserting a cause of action arising under the Securities Act, including all
causes of action asserted against any defendant named in such complaint. For the avoidance of doubt, this provision is intended to benefit
and may be enforced by our officers and directors, the underwriters engaged in respect to any offering giving rise to such complaint giving
rise to such complaint, any other professional entity whose profession gives authority to a statement made by that person or entity and
who has prepared or certified any part of the documents underlying the Business Combination. While the Delaware courts have determined
that such choice of forum provisions are facially valid, a stockholder may nevertheless seek to bring a claim in a venue other than those
designated in the exclusive forum provisions. In such instance, we would expect to vigorously assert the validity and enforceability of
the exclusive forum provisions of the Charter and Bylaws.
These exclusive forum provisions may limit a stockholder’s ability
to bring a claim in a judicial forum that it finds favorable for disputes with us or our directors, officers, or other employees and may
discourage these types of lawsuits, or could result in increased costs for a stockholder to bring a claim, particularly if they do not
reside in or near Delaware, both of which may discourage lawsuits against us or our directors, officers and employees.
Furthermore, the enforceability of similar choice of forum provisions
in other companies’ certificates of incorporation or bylaws has been challenged in legal proceedings, and it is possible that a
court could find these types of provisions to be inapplicable or unenforceable.
Exchange Listing
Our Common Stock and Public Warrants are
listed on the Nasdaq Capital Market under the symbol “CERO” and “CEROW,” respectively.
Transfer Agent and Registrar
The transfer agent and registrar for our securities is Continental
Stock Transfer & Trust Company. The transfer agent and registrar’s address is One State Street Plaza, 30th Floor,
New York, New York 10004, and its telephone number is (800) 509-5586.
Exhibit 10.13
SECURITIES PURCHASE
AGREEMENT
This SECURITIES PURCHASE
AGREEMENT (the “Agreement”), dated as of March 29, 2024, is by and among CERo Therapeutics Holdings, Inc. a Delaware
corporation with offices located at 201 Haskins Way, Suite 230, South San Francisco, CA 94080 (the “Company”), and
each of the investors listed on the Schedule of Buyers attached hereto (individually, a “Buyer” and collectively, the
“Buyers”).
RECITALS
A. On
February 5, 2024, each of the Company, then known as Phoenix Biotech Acquisition Corp. (“Phoenix”), CERo Therapeutics,
Inc. (“CERo”) and each of the investors party thereto (the “Series A Investors”) entered into that certain
Securities Purchase Agreement, which Original Securities Purchase Agreement was amended and restated on February 14, 2024 (as amended
and restated, the “Original Securities Purchase Agreement”), pursuant to which the Company issued Preferred Shares
(as defined therein), Common Warrants (as defined therein) and Preferred Warrants (as defined therein).
B. On
June 4, 2023, Phoenix entered into that certain Business Combination Agreement (as amended from time to time, the “Merger Agreement”),
with CERo, and PBCE Merger Sub, Inc., a Delaware corporation and wholly-owned subsidiary of Phoenix (“Merger Sub”),
pursuant to which, among other things, Merger Sub merged with and into CERo and, at the closing thereof on February 14, 2024 (the “Business
Combination Closing”, and such date, the “Business Combination Closing Date”), CERo, as the surviving entity,
became a wholly-owned subsidiary of the Company (the “Business Combination”).
D. The
Company and each Buyer is executing and delivering this Agreement in reliance upon the exemption from securities registration afforded
by Section 4(a)(2) of the Securities Act of 1933, as amended (the “1933 Act”), and Rule 506(b) of Regulation D (“Regulation D”)
as promulgated by the United States Securities and Exchange Commission (the “SEC”) under the 1933 Act.
E. The
Company has authorized (i) a new series of convertible preferred stock of the Company designated as Series B Convertible Preferred Stock,
$0.0001 par value per share, the terms of which are set forth in the certificate of designations of preferences and rights for such series
of preferred stock (the “Certificate of Designations”) in the form attached hereto as Exhibit A (together
with any convertible preferred shares issued in replacement thereof in accordance with the terms thereof, the “Series B Preferred
Stock”), which Series B Preferred Stock shall be convertible into shares of Common Stock (such shares of Common Stock issuable
pursuant to the terms of the Certificate of Designations, including, without limitation, upon conversion or otherwise, collectively, the
“Conversion Shares”), in accordance with the terms of the Certificate of Designations.
F. Each
Buyer wishes to purchase, and the Company wishes to sell, upon the terms and conditions stated in this Agreement, the aggregate number
of shares of Series B Preferred Stock (the “Series B Preferred Shares”) set forth opposite such Buyer’s name
in column (3) on the Schedule of Buyers. In addition, certain Series A Investors have agreed to transfer (the “Series A Transfers”)
to such Buyer Common Warrants (as defined in the Original Securities Purchase Agreement) and shares of Series A Convertible Preferred
Stock, $0.0001 par value per share (“Series A Preferred Stock”) purchased by such Series A Investors pursuant to the
Original Securities Purchase Agreement, which Series A Transfers may be effectuated through the forfeiture of securities by the Series
A Investors and reissuance of such securities by the Company.
G. On
the Closing Date, the parties hereto shall execute and deliver a Registration Rights Agreement, in the form attached hereto as Exhibit
B (the “Registration Rights Agreement”), pursuant to which the Company has agreed to provide certain registration
rights with respect to the Registrable Securities (as defined in the Registration Rights Agreement), under the 1933 Act and the rules
and regulations promulgated thereunder, and applicable state securities laws.
H. The
Series B Preferred Shares and the Conversion Shares are collectively referred to herein as the “Securities.”
AGREEMENT
NOW, THEREFORE, in consideration
of the premises and the mutual covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the Company and each Buyer hereby agree as follows:
1. PURCHASE
AND SALE OF PREFERRED SHARES.
(a) Purchase of Series
B Preferred Shares. Subject to the satisfaction (or waiver) of the conditions set forth in Sections 6 and 7 below, the Company shall
issue and sell to each Buyer, and each Buyer severally, but not jointly, agrees to purchase from the Company on the Closing Date (as
defined below) the aggregate number of Series B Preferred Shares as is set forth opposite such Buyer’s name in column (3) on the
Schedule of Buyers.
(b) Closing. The closing
(the “Closing”) of the purchase of the Series B Preferred Shares by the Buyers shall occur at the offices of Goodwin
Procter LLP, 620 Eighth Avenue, New York, NY 10018. The date and time of the Closing (the “Closing Date”) shall be
10:00 a.m., New York time, on the first (1st) Business Day on which the conditions to the Closing set forth in Sections 6 and 7 below
are satisfied or waived (or such other date as is mutually agreed to by the Company and each Buyer). As used herein “Business
Day” means any day other than Saturday, Sunday or other day on which commercial banks in The City of New York are authorized
or required by law to remain closed; provided, however, for clarification, commercial
banks shall not be deemed to be authorized or required by law to remain closed due to “stay at home”, “shelter-in-place”,
“non-essential employee” or any other similar orders or restrictions or the closure of any physical branch locations
at the direction of any governmental authority so long as the electronic funds transfer systems (including for wire transfers) of commercial
banks in The City of New York generally are open for use by customers on such day.
(c) Purchase Price.
The aggregate purchase price for the Series B Preferred Shares to be purchased by each Buyer (the “Purchase Price”)
shall be the amount set forth opposite such Buyer’s name in column (4) on the Schedule of Buyers (to be payable in cash or, at
the option of the Company, by cancellation of outstanding Indebtedness or securities of the Company, as applicable, as set forth opposite
in a footnote to column (4) on the Schedule of Buyers (the “Purchase Price Cancellation Notes”)).
(d) Form of Payment.
On the Closing Date, (i) each Buyer shall pay its respective Purchase Price (less, in the case of any Buyer, the amounts withheld pursuant
to Section 4(g) and/or cancellation of such aggregate outstanding principal and accrued interest on such Purchase Price Cancellation
Notes) to the Company for the Series B Preferred Shares to be issued and sold to such Buyer at the Closing, by wire transfer of immediately
available funds in accordance with the Flow of Funds Letter (as defined below) and (ii) the Company shall deliver to each Buyer
the aggregate number of Series B Preferred Shares as is set forth opposite such Buyer’s name in column (3) of the Schedule of Buyers,
duly executed on behalf of the Company and registered in the name of such Buyer or its designee.
2. BUYER’S
REPRESENTATIONS AND WARRANTIES.
Each Buyer, severally and
not jointly, represents and warrants to the Company with respect to only itself that, as of the date hereof and as of the Closing Date:
(a) Organization;
Authority. Such Buyer is either (i) an individual with sufficient legal capacity or (ii) an entity duly incorporated or organized,
validly existing and in good standing under the laws of the jurisdiction of its incorporation or organization, as applicable, with all
requisite power and authority, and has taken all requisite corporate or other action, as applicable, to enter into and to consummate the
transactions contemplated by the Transaction Documents (as defined below) to which it is a party and otherwise to carry out its obligations
hereunder and thereunder.
(b) No Public Sale or
Distribution. Such Buyer (i) is acquiring its Series B Preferred Shares, (ii) upon conversion of its Series B Preferred Shares and//or
the Series A Preferred Shares it obtains through a Series A Transfer will acquire the Conversion Shares issuable upon conversion thereof,
and (iii) upon exercise of its Common Warrants (other than pursuant to a Cashless Exercise (as defined in the Common Warrants))
it obtains pursuant to a Series A Transfer will acquire the Warrant Common Shares issuable upon exercise thereof, in each case, for its
own account and not with a view towards, or for resale in connection with, the public sale or distribution thereof in violation of applicable
securities laws, except pursuant to sales registered or exempted under the 1933 Act; provided, however, by making the representations
herein, such Buyer does not agree, or make any representation or warranty, to hold any of the Securities for any minimum or other specific
term and reserves the right to dispose of the Securities at any time in accordance with or pursuant to a registration statement or an
exemption from registration under the 1933 Act. Such Buyer does not presently have any agreement or understanding, directly or indirectly,
with any Person to distribute any of the Securities in violation of applicable securities laws. Such Buyer has no present intent to effect
a “change of control” of the Company as such term is understood under the rules promulgated pursuant to Section 13(d) of
the Exchange Act. For purposes of this Agreement, “Person” means an individual, a limited liability company, a partnership,
a joint venture, a corporation, a trust, an unincorporated organization, any other entity and any Governmental Entity (as defined below)
or any department or agency thereof.
(c) Accredited Investor
Status. Such Buyer is (a) either an “accredited investor” as that term is defined in Rule 501(a) of Regulation D or a
“qualified institutional buyer” as defined in Rule 144A(a) under the 1933 Act, (b) an “Institutional Account”
as defined in FINRA Rule 4512(c) and (c) a sophisticated institutional investor, experienced in investing in private equity transactions
and capable of evaluating investment risks independently, both in general and with regard to all transactions and investment strategies
involving a security or securities, including such Buyer’s participation in the transactions contemplated by this Agreement.
(d) Reliance on Exemptions.
Such Buyer understands that the Securities are being offered and sold to it in reliance on specific exemptions from the registration
requirements of United States federal and state securities laws and that the Company is relying in part upon the truth and accuracy of,
and such Buyer’s compliance with, the representations, warranties, agreements, acknowledgments and understandings of such Buyer
set forth herein in order to determine the availability of such exemptions and the eligibility of such Buyer to acquire the Securities.
Each Buyer further acknowledges and understands that the Securities may not be resold or otherwise transferred except in a transaction
registered under the Securities Act or unless an exemption from such registration is available.
(e) Information. Such
Buyer and its advisors, if any, have been furnished with all materials relating to the business, finances and operations of the Company
and materials relating to the offer and sale of the Securities that have been requested by such Buyer. Such Buyer and its advisors, if
any, have had the opportunity to review the Transaction Documents (including all exhibits and schedules thereto) and the SEC Documents
(as defined below) and have been afforded the opportunity to ask questions of the Company. Neither such inquiries nor any other due diligence
investigations conducted by such Buyer or its advisors, if any, or its representatives shall modify, amend or affect such Buyer’s
right to rely on the Company’s representations and warranties contained herein. Such Buyer understands that its investment in the
Securities involves a high degree of risk. Such Purchaser is able to bear the substantial risks associated with its purchase of the Securities,
including but not limited to loss of its entire investment therein. Such Buyer has sought such accounting, legal and tax advice as it
has considered necessary to make an informed investment decision with respect to its acquisition of the Securities. Such Buyer has determined
based on its own independent review and such professional advice as it deems appropriate that its purchase of the Securities and participation
in the transactions contemplated by this Agreement (i) are fully consistent with its financial needs, objectives and condition, (ii)
comply and are fully consistent with all investment policies, guidelines and other restrictions applicable to it, (iii) have been duly
authorized and approved by all necessary action, (iv) do not and will not violate or constitute a default under its charter, by-laws
or other constituent document or under any law, rule, regulation, agreement or other obligation by which it is bound and (v) are a fit,
proper and suitable investment for such Buyer, notwithstanding the substantial risks inherent in investing in or holding the Securities.
(f) No Governmental Review.
Such Buyer understands that no United States federal or state agency or any other government or governmental agency has passed on or
made any recommendation or endorsement of the Securities or the fairness or suitability of the investment in the Securities nor have
such authorities passed upon or endorsed the merits of the offering of the Securities.
(g) Transfer or Resale.
Such Buyer understands that except as provided in the Registration Rights Agreement and Section 4(h) hereof: (i) the Securities
have not been and are not being registered under the 1933 Act or any state securities laws, and may not be offered for sale, sold, assigned
or transferred unless (A) subsequently registered thereunder, or (B) such Buyer shall have delivered to the Company (if requested by
the Company) an opinion of counsel, in a form reasonably acceptable to the Company, to the effect that such Securities to be sold, assigned
or transferred may be sold, assigned or transferred pursuant to an exemption from such registration; and (ii) neither the Company nor
any other Person is under any obligation to register the Securities under the 1933 Act or any state securities laws or to comply with
the terms and conditions of any exemption thereunder. Notwithstanding the foregoing, the Securities may be pledged in connection with
a bona fide margin account or other loan or financing arrangement secured by the Securities and such pledge of Securities shall not be
deemed to be a transfer, sale or assignment of the Securities hereunder, and no Buyer effecting a pledge of Securities shall be required
to provide the Company with any notice thereof or otherwise make any delivery to the Company pursuant to this Agreement or any other
Transaction Document (as defined in Section 3(b)), including, without limitation, this Section 2(g) in connection with effecting
such pledge.
(h) Validity; Enforcement.
This Agreement and the Registration Rights Agreement have been duly and validly authorized, executed and delivered on behalf of such
Buyer and shall constitute the legal, valid and binding obligations of such Buyer enforceable against such Buyer in accordance with their
respective terms, except as such enforceability may be limited by general principles of equity or to applicable bankruptcy, insolvency,
reorganization, moratorium, liquidation and other similar laws relating to, or affecting generally, the enforcement of applicable creditors’
rights and remedies.
(i) No Conflicts.
The execution, delivery and performance by such Buyer of this Agreement and the Registration Rights Agreement and the consummation by
such Buyer of the transactions contemplated hereby and thereby will not (i) result in a violation of the organizational documents of
such Buyer, or (ii) conflict with, or constitute a default (or an event which with notice or lapse of time or both would become a default)
under, or give to others any rights of termination, amendment, acceleration or cancellation of, any agreement, indenture or instrument
to which such Buyer is a party, or (iii) result in a violation of any law, rule, regulation, order, judgment or decree (including federal
and state securities laws) applicable to such Buyer, except in the case of clauses (ii) and (iii) above, for such conflicts, defaults,
rights or violations which could not, individually or in the aggregate, reasonably be expected to have a material adverse effect on the
ability of such Buyer to perform its obligations hereunder.
(j) Residency.
Such Buyer is a resident of that jurisdiction specified below its address on the Schedule of Buyers.
(k) No
“Bad Actor” Disqualification. Such Buyer has not taken any of the actions set forth in, and is not subject to, the disqualification
provisions of Rule 506(d)(1) of the 1933 Act. Neither such Buyer nor any of its Rule 506(d) Related Parties is a “bad actor”
within the meaning of Rule 506(d) of the Securities Act. For purposes of this Agreement, a “Rule 506(d) Related Party” shall
mean a person or entity covered by the “Bad Actor disqualification” provision of Rule 506(d) of the Securities Act.
(l) Certain
Trading Activities. Such Buyer is aware that the anti-manipulation rules of Regulation M under the 1934 Act may apply to sales of
Securities and other activities with respect to the Securities by the Buyer. As of the earlier of (i) the Company has made a public announcement
concerning this Agreement and the sale and issuance of the Securities or (ii) 9:00 am New York time on the first (1st)
Trading Day immediately after the date of the signing of this Agreement (the “Disclosure Deadline”), neither such Buyer
nor any person acting on behalf of or pursuant to any understanding with such Buyer shall have, directly or indirectly, engaged in any
purchases or sales of the Company’s securities (including all “short sales” as defined in Rule 200 of Regulation SHO
of the Exchange Act (“Short Sales”) involving the Company’s securities) since the time that such Buyer was first
contacted by the Company, the Placement Agents or any other person regarding the purchases or sales contemplated hereby. Notwithstanding
the foregoing, in the case of a Buyer that is a multi-managed investment bank or vehicle whereby separate portfolio managers manage separate
portions of such Buyer’s assets, this Section 3(l) shall apply only with respect to the portfolio manager that made the investment
decision to purchase the Securities covered by this Agreement. Each Buyer covenants that neither such Buyer nor any person acting on such
Buyer’s behalf or pursuant to any understanding with such Buyer will engage in any purchases or sales of the Company’s securities
(including any Short Sales involving the Company’s securities) prior to the time that all material nonpublic information disclosed
to such Buyer is publicly disclosed. Notwithstanding the foregoing, in the case of a Buyer that is a multi-managed investment bank or
vehicle whereby separate portfolio managers manage separate portions of such Buyer’s assets, this representation shall only apply
with respect to the portfolio manager that made the investment decision to purchase the Securities covered by this Agreement.
(m) No
Reliance on Placement Agents. Such Buyer acknowledges and agrees that neither the Placement Agents (as defined below) nor any affiliate
of the Placement Agents has provided such Buyer with any information or advice with respect to the Securities nor is such information
or advice necessary or desired. Neither the Placement Agents nor any affiliate has made or makes any representation as to the Company
or the quality of the Securities and the Placement Agents and any affiliate may have acquired non-public information with respect to the
Company which such Buyer agrees need not be provided to it. In connection with the issuance of the Securities to such Buyer, neither the
Placement Agents nor any of its affiliates has acted as a financial advisor or fiduciary to such Buyer.
3. REPRESENTATIONS
AND WARRANTIES OF THE COMPANY.
The Company represents and
warrants to each of the Buyers that, as of the date hereof and as of the Closing Date (other than the representations and warranties set
forth in Sections 3(f), 3(l), 3(o), 3(u), 3(v), 3(w), 3(dd), 3(ww) and 3(vv), which shall only be made as of the Closing
Date):
(a) Organization and Qualification.
Each of the Company and each of its Subsidiaries are entities duly organized and validly existing and in good standing under the laws
of the jurisdiction in which they are formed, and have the requisite power and authority to own their properties and to carry on their
business as now being conducted and as presently proposed to be conducted. Each of the Company and each of its Subsidiaries is duly qualified
as a foreign entity to do business and is in good standing in every jurisdiction in which its ownership of property or the nature of
the business conducted by it makes such qualification necessary, except to the extent that the failure to be so qualified or be in good
standing would not reasonably be expected to have a Material Adverse Effect (as defined below). As used in this Agreement, “Material
Adverse Effect” means any material adverse effect on (i) the business, properties, assets, liabilities, operations (including
results thereof), condition (financial or otherwise) or prospects of the Company or any Subsidiary (as defined below), taken as a whole,
(ii) the transactions contemplated hereby or in any of the other Transaction Documents or any other agreements or instruments to be entered
into in connection herewith or therewith or (iii) the authority or ability of the Company or any of its Subsidiaries to perform any of
their respective obligations under any of the Transaction Documents (as defined below). Other than the Persons (as defined below) set
forth on Schedule 3(a), the Company has no Subsidiaries. “Subsidiaries” means any Person in which the Company,
directly or indirectly, (I) owns any of the outstanding capital stock or holds any equity or similar interest of such Person or (II)
controls or operates all or any part of the business, operations or administration of such Person, and each of the foregoing, is individually
referred to herein as a “Subsidiary.”
(b) Authorization; Enforcement;
Validity. The Company has the requisite power and authority to enter into and perform its obligations under this Agreement and the
other Transaction Documents and to issue the Securities in accordance with the terms hereof and thereof. Each Subsidiary has the requisite
power and authority to enter into and perform its obligations under the Transaction Documents to which it is a party. The execution and
delivery of this Agreement and the other Transaction Documents by the Company, and the consummation by the Company of the transactions
contemplated hereby and thereby (including, without limitation, the issuance of the Series B Preferred Shares and the reservation for
issuance and issuance of the Conversion Shares issuable upon conversion of the Series B Preferred Shares) have been duly authorized by
the Company’s board of directors or other governing body, as applicable, and (other than the filing with the SEC of one or more
Registration Statements (as defined in the Registration Rights Agreement) in accordance with the requirements of the Registration Rights
Agreement, and a Form D and any other filings as may be required by any state securities agencies, the filing of the Certificate of Designations
with the Secretary of State of the State of Delaware, and the notice and/or application(s) to the Principal Market for the issuance and
sale of the Securities and the listing of the Conversion Shares for trading thereon in the time and manner required thereby (collectively,
the “Required Approvals”)) no further filing, consent or authorization is required by the Company, its Subsidiaries,
their respective boards of directors or their stockholders or other governing body. This Agreement has been, and the other Transaction
Documents to which it is a party will be prior to the Closing, duly executed and delivered by the Company, and each constitutes the legal,
valid and binding obligations of the Company, enforceable against the Company in accordance with its respective terms, except as such
enforceability may be limited by general principles of equity or applicable bankruptcy, insolvency, reorganization, moratorium, liquidation
or similar laws relating to, or affecting generally, the enforcement of applicable creditors’ rights and remedies and except as
rights to indemnification and to contribution may be limited by federal or state securities law. Prior to the Closing, the Certificate
of Designations in the form attached hereto as Exhibit A will have been filed with the Secretary of State of the State
of Delaware and will be in full force and effect, enforceable against the Company in accordance with its terms and has not have been
amended. “Transaction Documents” means, collectively, this Agreement, the Series B Preferred Shares, the Certificate
of Designations, the Registration Rights Agreement, the Irrevocable Transfer Agent Instructions (as defined below) and each of the other
agreements and instruments entered into or delivered by any of the parties hereto in connection with the transactions contemplated hereby
and thereby, as may be amended from time to time.
(c) Issuance of Securities.
The issuance of the Series B Preferred Shares has been duly authorized and, upon issuance in accordance with the terms of the Transaction
Documents, shall be validly issued, fully paid and non-assessable and free from all preemptive or similar rights, mortgages, defects,
claims, liens, pledges, charges, taxes, rights of first refusal, encumbrances, security interests and other encumbrances (collectively
“Liens”) with respect to the issuance thereof. As of the Closing, the Company shall have reserved from its duly authorized
capital stock not less than 150% of the maximum number of Conversion Shares issuable upon conversion of the Series B Preferred Shares,
assuming for purposes hereof that the Preferred Shares are convertible at the Alternate Conversion Price (as defined in the Certificate
of Designations) assuming an Alternate Conversion Date (as defined in the Certificate of Designations) as of the date hereof. Upon issuance
or conversion in accordance with the Series B Preferred Shares, the Conversion Shares, when issued, will be validly issued, fully paid
and nonassessable and free from all preemptive or similar rights or Liens with respect to the issue thereof, with the holders being entitled
to all rights accorded to a holder of Common Stock and/or Series B Preferred Stock, as applicable. Subject to the accuracy of the representations
and warranties of the Buyers in this Agreement, the offer and issuance by the Company of the Securities is exempt from registration under
the 1933 Act.
(d) No Conflicts.
The execution, delivery and performance of the Transaction Documents by the Company and the consummation by the Company of the transactions
contemplated hereby and thereby (including, without limitation, the issuance of the Securities and the reservation for issuance of the
Conversion Shares) will not (i) result in a violation of the Certificate of Incorporation (as defined below) (including, without limitation,
any certificate of designation contained therein), Bylaws (as defined below), certificate of formation, memorandum of association, articles
of association, bylaws or other organizational documents of the Company or any of its Subsidiaries, or any capital stock or other securities
of the Company or any of its Subsidiaries, (ii) conflict with, or constitute a default (or an event which with notice or lapse of time
or both would become a default) in any respect under, or give to others any rights of termination, amendment, acceleration or cancellation
of, any agreement, indenture or instrument to which the Company or any of its Subsidiaries is a party, or (iii) result in a violation
of any law, rule, regulation, order, judgment or decree (including, without limitation, foreign, federal and state securities laws and
regulations and the rules and regulations of the Nasdaq Global Market (the “Principal Market”) and including all applicable
foreign, federal and state laws, rules and regulations) applicable to the Company or any of its Subsidiaries or by which any property
or asset of the Company or any of its Subsidiaries is bound or affected; except in the case of each of clauses (ii) and (iii), such as
would not have or reasonably be expected to result in a Material Adverse Effect.
(e) Consents. Neither
the Company nor any Subsidiary is required to obtain any consent from, authorization or order of, or make any filing or registration
with (other than the Required Approvals) any Governmental Entity (as defined below) or any regulatory or self-regulatory agency or any
other Person in order for it to execute, deliver or perform any of its respective obligations under or contemplated by the Transaction
Documents, in each case, in accordance with the terms hereof or thereof. All consents, authorizations, orders, filings and registrations
which the Company or any Subsidiary is required to obtain pursuant to the preceding sentence have been or will be obtained or effected
on or prior to the Closing Date, and neither the Company nor any of its Subsidiaries are aware of any facts or circumstances which might
prevent the Company or any of its Subsidiaries from obtaining or effecting any of the registration, application or filings contemplated
by the Transaction Documents. The Company is not in violation of the requirements of the Principal Market and has no knowledge of any
facts or circumstances which could reasonably lead to delisting or suspension of the Common Stock in the foreseeable future. “Governmental
Entity” means any nation, state, county, city, town, village, district, or other political jurisdiction of any nature, federal,
state, local, municipal, foreign, or other government, governmental or quasi-governmental authority of any nature (including any governmental
agency, branch, department, official, or entity and any court or other tribunal), multi-national organization or body; or body exercising,
or entitled to exercise, any administrative, executive, judicial, legislative, police, regulatory, or taxing authority or power of any
nature or instrumentality of any of the foregoing, including any entity or enterprise owned or controlled by a government or a public
international organization or any of the foregoing.
(f) Acknowledgment Regarding
Buyer’s Purchase of Securities. The Company acknowledges and agrees that each Buyer is acting solely in the capacity of an
arm’s length purchaser with respect to the Transaction Documents and the transactions contemplated hereby and thereby and that
no Buyer (other than such Person as set forth on Schedule 3(f) attached hereto, each an “Insider Buyer”) is (i) an
officer or director of the Company or any of its Subsidiaries, (ii) an “affiliate” (as defined in Rule 144 or Rule 144A promulgated
under the 1933 Act (or a successor rule thereto) (collectively, “Rule 144”)) of the Company or any of its Subsidiaries
or (iii) to its knowledge, a “beneficial owner” of more than 10% of the shares of Common Stock (as defined for purposes of
Rule 13d-3 of the Securities Exchange Act of 1934, as amended (the “1934 Act”)). The Company further acknowledges
that no Buyer is acting as a financial advisor or fiduciary of the Company or any of its Subsidiaries (or in any similar capacity) with
respect to the Transaction Documents and the transactions contemplated hereby and thereby, and any advice given by a Buyer or any of
its representatives or agents in connection with the Transaction Documents and the transactions contemplated hereby and thereby is merely
incidental to such Buyer’s purchase of the Securities. The Company further represents to each Buyer that the Company’s and
each Subsidiary’s decision to enter into the Transaction Documents to which it is a party has been based solely on the independent
evaluation by the Company, each Subsidiary and their respective representatives.
(g) No General Solicitation;
Placement Agents’ Fees. Neither the Company, nor any of its Subsidiaries or affiliates, nor any Person acting on its or their
behalf, has engaged in any form of general solicitation or general advertising (within the meaning of Regulation D) in connection with
the offer or sale of the Securities. The Company shall be responsible for the payment of any placement agent’s fees, financial
advisory fees, or brokers’ commissions (other than for Persons engaged by any Buyer or its investment advisor) relating to or arising
out of the transactions contemplated hereby, including, without limitation, placement agent fees payable to BTIG, LLC, Cohen & Company
Capital Markets, a division of J.V.B. Financial Group, LLC, and Oppenheimer & Co. Inc. as placement agents (the “Placement
Agents”) in connection with the sale of the Securities. The Company shall pay, and hold each Buyer harmless against, any liability,
loss or expense (including, without limitation, attorney’s fees and out-of-pocket expenses) arising in connection with any such
claim. The Company acknowledges that it has engaged the Placement Agents in connection with the sale of the Securities. Other than the
Placement Agents, neither the Company nor any of its Subsidiaries has engaged any placement agent or other agent in connection with the
offer or sale of the Securities.
(h) No Integrated Offering.
None of the Company, its Subsidiaries or any of their affiliates, nor any Person acting on their behalf has, directly or indirectly,
made any offers or sales of any security or solicited any offers to buy any security, under circumstances that would require registration
of the issuance of any of the Securities under the 1933 Act, whether through integration with prior offerings or otherwise, or caused
this offering of the Securities to require approval of stockholders of the Company for purposes of the 1933 Act or under any applicable
stockholder approval provisions, including, without limitation, under the rules and regulations of any exchange or automated quotation
system on which any of the securities of the Company are listed or designated for quotation. None of the Company, its Subsidiaries, their
affiliates nor any Person acting on their behalf will take any action or steps that would require registration of the issuance of any
of the Securities under the 1933 Act (other than pursuant to the Registration Rights Agreement) or cause the offering of any of the Securities
to be integrated with other offerings of securities of the Company.
(i) Dilutive Effect.
The Company understands and acknowledges that the number of Conversion Shares will increase in certain circumstances. The Company further
acknowledges that its obligation to issue the Conversion Shares pursuant to the terms of the Series B Preferred Shares in accordance
with this Agreement and the Certificate of Designations is absolute and unconditional regardless of the dilutive effect that such issuance
may have on the ownership interests of other stockholders of the Company.
(j) Application of Takeover
Protections; Rights Agreement. The Company and its board of directors have taken all necessary action, if any, in order to render
inapplicable any control share acquisition, interested stockholder, business combination, poison pill (including, without limitation,
any distribution under a rights agreement), stockholder rights plan or other similar anti-takeover provision under the Certificate of
Incorporation, Bylaws or other organizational documents or the laws of the jurisdiction of its incorporation or otherwise which is or
could become applicable to any Buyer as a result of the transactions contemplated by this Agreement, including, without limitation, the
Company’s issuance of the Securities and any Buyer’s ownership of the Securities. The Company and its board of directors
have taken all necessary action, if any, in order to render inapplicable any stockholder rights plan or similar arrangement relating
to accumulations of beneficial ownership of shares of Common Stock or a change in control of the Company or any of its Subsidiaries.
(k) SEC Documents; Financial
Statements. Except as set forth on Schedule 3(k), during the two (2) years prior to the date hereof, the Company has timely filed
all reports, schedules, forms, proxy statements, statements and other documents required to be filed by it with the SEC pursuant to the
reporting requirements of the 1934 Act (all of the foregoing filed prior to the date hereof and all exhibits and appendices included
therein and financial statements, notes and schedules thereto and documents incorporated by reference therein being hereinafter referred
to as the “SEC Documents”). The Company has delivered or has made available to the Buyers or their respective representatives
true, correct and complete copies of each of the SEC Documents requested by any such Buyer and not available on the EDGAR system. As
of their respective dates, the SEC Documents complied in all material respects with the requirements of the 1934 Act and the rules and
regulations of the SEC promulgated thereunder applicable to the SEC Documents, and none of the SEC Documents, at the time they were filed
with the SEC, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or
necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. As of
their respective dates, the financial statements of the Company included in the SEC Documents complied in all material respects with
applicable accounting requirements and the published rules and regulations of the SEC with respect thereto as in effect as of the time
of filing. Such financial statements have been prepared in accordance with generally accepted accounting principles (“GAAP”),
consistently applied, during the periods involved (except (i) as may be otherwise indicated in such financial statements or the notes
thereto, or (ii) in the case of unaudited interim statements, to the extent they may exclude footnotes or may be condensed or summary
statements) and fairly present in all material respects the financial position of the Company as of the dates thereof and the results
of its operations and cash flows for the periods then ended (subject, in the case of unaudited statements, to normal year-end audit adjustments
which will not be material, either individually or in the aggregate). The reserves, if any, established by the Company or the lack of
reserves, if applicable, are reasonable based upon facts and circumstances known by the Company on the date hereof and there are no loss
contingencies that are required to be accrued by the Statement of Financial Accounting Standard No. 5 of the Financial Accounting Standards
Board which are not provided for by the Company in its financial statements or otherwise. No other information provided by or on behalf
of the Company to any of the Buyers which is not included in the SEC Documents (including, without limitation, information referred to
in Section 2(e) of this Agreement or in the disclosure schedules to this Agreement) contains any untrue statement of a material
fact or omits to state any material fact necessary in order to make the statements therein not misleading, in the light of the circumstance
under which they are or were made. The Company is not currently contemplating to amend or restate any of the financial statements (including,
without limitation, any notes or any letter of the independent accountants of the Company with respect thereto) included in the SEC Documents
(the “Financial Statements”), nor is the Company currently aware of facts or circumstances which would require the
Company to amend or restate any of the Financial Statements, in each case, in order for any of the Financials Statements to be in compliance
with GAAP and the rules and regulations of the SEC. The Company has not been informed by its independent accountants that they recommend
that the Company amend or restate any of the Financial Statements or that there is any need for the Company to amend or restate any of
the Financial Statements.
(l) Absence of Certain
Changes. Since the date of the Company’s most recent audited financial statements contained in the Company’s Registration
Statement on Form S-4 (File No. 333-272467), declared effective on January 19, 2024 (the “Business Combination Registration
Statement”), there has been no material adverse change and no material adverse development in the business, assets, liabilities,
properties, operations (including results thereof), condition (financial or otherwise) or prospects of the Company or any of its Subsidiaries.
Since the date of the Company’s most recent audited financial statements contained in the Business Combination Registration Statement,
neither the Company nor any of its Subsidiaries has (i) declared or paid any dividends, (ii) sold any assets, individually or in the
aggregate, outside of the ordinary course of business or (iii) made any capital expenditures, individually or in the aggregate, outside
of the ordinary course of business. Neither the Company nor any of its Subsidiaries has taken any steps to seek protection pursuant to
any law or statute relating to bankruptcy, insolvency, reorganization, receivership, liquidation or winding up, nor does the Company
or any Subsidiary have any knowledge or reason to believe that any of their respective creditors intend to initiate involuntary bankruptcy
proceedings or any actual knowledge of any fact which would reasonably lead a creditor to do so. The Company and its Subsidiaries, individually
and on a consolidated basis, after giving effect to the transactions contemplated hereby to occur at the Closing, will not be Company
Insolvent (as defined below). For purposes of this Section 3(l), “Company Insolvent” means, (i) with respect
to the Company and its Subsidiaries, on a consolidated basis, (A) the present fair saleable value of the Company’s and its Subsidiaries’
assets is less than the amount required to pay the Company’s and its Subsidiaries’ total Indebtedness (as defined below),
(B) the Company and its Subsidiaries are unable to pay their debts and liabilities, subordinated, contingent or otherwise, as such debts
and liabilities become absolute and matured or (C) the Company and its Subsidiaries intend to incur or believe that they will incur debts
that would be beyond their ability to pay as such debts mature; and (ii) with respect to the Company and each Subsidiary, individually,
(A) the present fair saleable value of the Company’s or such Subsidiary’s (as the case may be) assets is less than the amount
required to pay its respective total Indebtedness, (B) the Company or such Subsidiary (as the case may be) is unable to pay its respective
debts and liabilities, subordinated, contingent or otherwise, as such debts and liabilities become absolute and matured or (C) the Company
or such Subsidiary (as the case may be) intends to incur or believes that it will incur debts that would be beyond its respective ability
to pay as such debts mature. Neither the Company nor any of its Subsidiaries has engaged in any business or in any transaction, and is
not about to engage in any business or in any transaction, for which the Company’s or such Subsidiary’s remaining assets
constitute unreasonably small capital with which to conduct the business in which it is engaged as such business is now conducted and
is proposed to be conducted.
(m) No Undisclosed Events,
Liabilities, Developments or Circumstances. To the Company’s knowledge, no event, liability, development or circumstance has
occurred or exists, or is reasonably expected to exist or occur with respect to the Company, any of its Subsidiaries or any of their
respective businesses, properties, liabilities, prospects, operations (including results thereof) or condition (financial or otherwise),
that (i) would be required to be disclosed by the Company under applicable securities laws on a registration statement on Form S-1 filed
with the SEC relating to an issuance and sale by the Company of its Common Stock and which has not been publicly announced, (ii) could
have a material adverse effect on any Buyer’s investment hereunder or (iii) could have a Material Adverse Effect.
(n) Conduct of Business;
Regulatory Permits. Neither the Company nor any of its Subsidiaries is in violation of any term of or in default under its organizational
charter, certificate of formation, memorandum of association, articles of association, Certificate of Incorporation or bylaws. Neither
the Company nor any of its Subsidiaries is in violation of any judgment, decree or order or any statute, ordinance, rule or regulation
applicable to the Company or any of its Subsidiaries, and neither the Company nor any of its Subsidiaries will conduct its business in
violation of any of the foregoing, except in all cases for possible violations which could not, individually or in the aggregate, have
a Material Adverse Effect. Except as disclosed in the SEC Documents, without limiting the generality of the foregoing, the Company is
not violation of any of the rules, regulations or requirements of the Principal Market and has no knowledge of any facts or circumstances
that could reasonably lead to delisting or suspension of the Common Stock by the Principal Market in the foreseeable future. Since June
5, 2023, except as set forth on Schedule 3(n), (i) the Common Stock has been listed or designated for quotation on the Principal Market,
(ii) trading in the Common Stock has not been suspended by the SEC or the Principal Market and (iii) the Company has received no communication,
written or oral, from the SEC or the Principal Market regarding the suspension or delisting of the Common Stock from the Principal Market.
The Company and each of its Subsidiaries possess all certificates, authorizations and permits issued by the appropriate regulatory authorities
necessary to conduct their respective businesses, except where the failure to possess such certificates, authorizations or permits would
not have, individually or in the aggregate, a Material Adverse Effect, and neither the Company nor any such Subsidiary has received any
notice of proceedings relating to the revocation or modification of any such certificate, authorization or permit. There is no agreement,
commitment, judgment, injunction, order or decree binding upon the Company or any of its Subsidiaries or to which the Company or any
of its Subsidiaries is a party which has or would reasonably be expected to have the effect of prohibiting or materially impairing any
business practice of the Company or any of its Subsidiaries, any acquisition of property by the Company or any of its Subsidiaries or
the conduct of business by the Company or any of its Subsidiaries as currently conducted other than such effects, individually or in
the aggregate, which have not had and would not reasonably be expected to have a Material Adverse Effect on the Company or any of its
Subsidiaries.
(o) Foreign Corrupt Practices.
Neither the Company, the Company’s subsidiary or any director, officer, agent, employee, nor any other person acting for or on
behalf of the foregoing (individually and collectively, a “Company Affiliate”) have violated the U.S. Foreign Corrupt
Practices Act (the “FCPA”) or any other applicable anti-bribery or anti-corruption laws, nor has any Company Affiliate
offered, paid, promised to pay, or authorized the payment of any money, or offered, given, promised to give, or authorized the giving
of anything of value, to any officer, employee or any other person acting in an official capacity for any Governmental Entity to any
political party or official thereof or to any candidate for political office (individually and collectively, a “Government Official”)
or to any person under circumstances where such Company Affiliate knew or was aware of a high probability that all or a portion of such
money or thing of value would be offered, given or promised, directly or indirectly, to any Government Official, for the purpose of:
(i) (A)
influencing any act or decision of such Government Official in his/her official capacity, (B) inducing such Government Official to do
or omit to do any act in violation of his/her lawful duty, (C) securing any improper advantage, or (D) inducing such Government Official
to influence or affect any act or decision of any Governmental Entity, or
(ii) assisting
the Company or its Subsidiaries in obtaining or retaining business for or with, or directing business to, the Company or its Subsidiaries.
(p) Sarbanes-Oxley Act.
The Company and each Subsidiary is in compliance with any and all applicable requirements of the Sarbanes-Oxley Act of 2002, as amended,
and any and all applicable rules and regulations promulgated by the SEC thereunder.
(q) Transactions With
Affiliates. Except as disclosed in the SEC Documents or as set forth on Schedule 3(q), no current or former employee, partner, director,
officer or stockholder (direct or indirect) of the Company or its Subsidiaries, or any associate, or, to the knowledge of the Company,
any affiliate of any thereof, or any relative with a relationship no more remote than first cousin of any of the foregoing, is presently,
or has ever been, (i) a party to any transaction with the Company or its Subsidiaries (including any contract, agreement or other arrangement
providing for the furnishing of services by, or rental of real or personal property from, or otherwise requiring payments to, any such
director, officer or stockholder or such associate or affiliate or relative Subsidiaries (other than for ordinary course services as
employees, officers or directors of the Company or any of its Subsidiaries)) or (ii) the direct or indirect owner of an interest in any
corporation, firm, association or business organization which is a competitor, supplier or customer of the Company or its Subsidiaries
(except for a passive investment (direct or indirect) in less than 5% of the common stock of a company whose securities are traded on
or quoted through an Eligible Market (as defined in the Certificate of Designations)), nor does any such Person receive income from any
source other than the Company or its Subsidiaries which relates to the business of the Company or its Subsidiaries or should properly
accrue to the Company or its Subsidiaries. No employee, officer, stockholder or director of the Company or any of its Subsidiaries or
member of his or her immediate family is indebted to the Company or its Subsidiaries, as the case may be, nor is the Company or any of
its Subsidiaries indebted (or committed to make loans or extend or guarantee credit) to any of them, other than (i) for payment of salary
for services rendered, (ii) reimbursement for reasonable expenses incurred on behalf of the Company, and (iii) for other standard employee
benefits made generally available to all employees or executives (including stock option agreements outstanding under any stock option
plan approved by the Board of Directors of the Company).
(r) Equity
Capitalization.
(i) Definitions:
(A) “Common
Stock” means (x) the Company’s shares of common stock, $0.0001 par value per share, and (y) any capital stock into
which such common stock shall have been changed or any share capital resulting from a reclassification of such common stock.
(B) “Preferred
Stock” means (x) the Company’s blank check preferred stock, $0.0001 par value per share, the terms of which may be designated
by the board of directors of the Company in a certificate of designations and (y) any capital stock into which such preferred stock shall
have been changed or any share capital resulting from a reclassification of such preferred stock (other than a conversion of such preferred
stock into Common Stock in accordance with the terms of such certificate of designations).
(ii) Authorized
and Outstanding Capital Stock. As of the date hereof, the authorized capital stock of the Company consists of (A) 1,000,000,000 shares
of Common Stock, of which 14,707,000 are issued and outstanding and 16,002,004 shares are reserved for issuance pursuant to Convertible
Securities (as defined below) (other than the Preferred Shares and the Warrants) exercisable or exchangeable for, or convertible into,
(B) 10,000,000 shares of Preferred Stock, none of which are issued and outstanding. As of the Closing Date, the authorized capital stock
of the Company will consist of (A) 1,000,000,000 shares of Common Stock, of which, 14,707,000 will be issued and outstanding and 16,002,004
shares will be reserved for issuance pursuant to Convertible Securities (as defined below) (other than the Warrants) exercisable or exchangeable
for, or convertible into, shares of Common Stock and (B) 10,000,000 shares of Preferred Stock, 10,756 of which will be issued and outstanding.
No shares of Common Stock are held in the treasury of the Company as of the date hereof and no shares of Common Stock will be held in
the treasury of the Company as of the Closing Date. “Convertible Securities” means any capital stock or other security
of the Company or any of its Subsidiaries that is at any time and under any circumstances directly or indirectly convertible into, exercisable
or exchangeable for, or which otherwise entitles the holder thereof to acquire, any capital stock or other security of the Company (including,
without limitation, Common Stock) or any of its Subsidiaries.
(iii) Valid
Issuance; Available Shares; Affiliates. All of such outstanding shares are duly authorized and have been, or upon issuance will be,
validly issued and are fully paid and nonassessable. Schedule 3(r)(iii) sets forth the number of shares of Common Stock that are
(A) reserved for issuance pursuant to Convertible Securities (as defined below) (other than the Series B Preferred Shares) and (B) that
are, as of the date hereof, owned by Persons who are “affiliates” (as defined in Rule 405 of the 1933 Act and calculated based
on the assumption that only officers, directors and holders of at least 10% of the Company’s issued and outstanding Common Stock
are “affiliates” without conceding that any such Persons are “affiliates” for purposes of federal securities laws)
of the Company or any of its Subsidiaries. Other than the Insider Buyers and as disclosed in the SEC Documents, to the Company’s
knowledge, no Person owns 10% or more of the Company’s issued and outstanding shares of Common Stock (calculated based on the assumption
that all Convertible Securities (as defined below), whether or not presently exercisable or convertible, have been fully exercised or
converted (as the case may be) taking account of any limitations on exercise or conversion (including “blockers”) contained
therein without conceding that such identified Person is a 10% stockholder for purposes of federal securities laws).
(iv) Existing
Securities; Obligations. Except as disclosed in the SEC Documents: (A) none of the Company’s or any Subsidiary’s shares,
interests or capital stock is subject to preemptive rights or any other similar rights or Liens suffered or permitted by the Company or
any Subsidiary; (B) there are no outstanding options, warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever
relating to, or securities or rights convertible into, or exercisable or exchangeable for, any shares, interests or capital stock of the
Company or any of its Subsidiaries, or contracts, commitments, understandings or arrangements by which the Company or any of its Subsidiaries
is or may become bound to issue additional shares, interests or capital stock of the Company or any of its Subsidiaries or options, warrants,
scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights convertible into,
or exercisable or exchangeable for, any shares, interests or capital stock of the Company or any of its Subsidiaries; (C) there are no
agreements or arrangements under which the Company or any of its Subsidiaries is obligated to register the sale of any of their securities
under the 1933 Act (except pursuant to the Registration Rights Agreement); (D) there are no outstanding securities or instruments of the
Company or any of its Subsidiaries which contain any redemption or similar provisions, and there are no contracts, commitments, understandings
or arrangements by which the Company or any of its Subsidiaries is or may become bound to redeem a security of the Company or any of its
Subsidiaries; (E) there are no securities or instruments containing anti-dilution or similar provisions that will be triggered by the
issuance of the Securities; and (F) neither the Company nor any Subsidiary has any stock appreciation rights or “phantom stock”
plans or agreements or any similar plan or agreement.
(v) Organizational
Documents. The Company has furnished to the Buyers, or publicly filed with the SEC, true, correct and complete copies of the Company’s
Certificate of Incorporation, as amended and as in effect on the date hereof (the “Certificate of Incorporation”),
and the Company’s bylaws, as amended and as in effect on the date hereof (the “Bylaws”), and the terms of all
Convertible Securities and the material rights of the holders thereof in respect thereto.
(s) Indebtedness and Other
Contracts. Except as set forth on Schedule 3(s), neither the Company nor any of its Subsidiaries, (i) has any outstanding debt securities,
notes, credit agreements, credit facilities or other agreements, documents or instruments evidencing Indebtedness of the Company or any
of its Subsidiaries or by which the Company or any of its Subsidiaries is or may become bound, (ii) is a party to any contract, agreement
or instrument, the violation of which, or default under which, by the other party(ies) to such contract, agreement or instrument could
reasonably be expected to result in a Material Adverse Effect, (iii) has any financing statements securing obligations in any amounts
filed in connection with the Company or any of its Subsidiaries; (iv) is in violation of any term of, or in default under, any contract,
agreement or instrument relating to any Indebtedness, except where such violations and defaults would not result, individually or in
the aggregate, in a Material Adverse Effect, or (v) is a party to any contract, agreement or instrument relating to any Indebtedness,
the performance of which, in the judgment of the Company’s officers, has or is expected to have a Material Adverse Effect. Neither
the Company nor any of its Subsidiaries have any liabilities or obligations required to be disclosed in the SEC Documents which are not
so disclosed in the SEC Documents, other than those incurred in the ordinary course of the Company’s or its Subsidiaries’
respective businesses and which, individually or in the aggregate, do not or could not have a Material Adverse Effect. For purposes of
this Agreement: (x) “Indebtedness” of any Person means, without duplication (A) all indebtedness for borrowed money,
(B) all obligations issued, undertaken or assumed as the deferred purchase price of property or services (including, without limitation,
“capital leases” in accordance with GAAP) (other than trade payables entered into in the ordinary course of business consistent
with past practice), (C) all reimbursement or payment obligations with respect to letters of credit, surety bonds and other similar instruments,
(D) all obligations evidenced by notes, bonds, debentures or similar instruments, including obligations so evidenced incurred in connection
with the acquisition of property, assets or businesses, (E) all indebtedness created or arising under any conditional sale or other title
retention agreement, or incurred as financing, in either case with respect to any property or assets acquired with the proceeds of such
indebtedness (even though the rights and remedies of the seller or bank under such agreement in the event of default are limited to repossession
or sale of such property), (F) all monetary obligations under any leasing or similar arrangement which, in connection with GAAP, consistently
applied for the periods covered thereby, is classified as a capital lease, (G) all indebtedness referred to in clauses (A) through (F)
above secured by (or for which the holder of such Indebtedness has an existing right, contingent or otherwise, to be secured by) any
Lien upon or in any property or assets (including accounts and contract rights) owned by any Person, even though the Person which owns
such assets or property has not assumed or become liable for the payment of such indebtedness, and (H) all Contingent Obligations in
respect of indebtedness or obligations of others of the kinds referred to in clauses (A) through (G) above; and (y) “Contingent
Obligation” means, as to any Person, any direct or indirect liability, contingent or otherwise, of that Person with respect
to any Indebtedness, lease, dividend or other obligation of another Person if the primary purpose or intent of the Person incurring such
liability, or the primary effect thereof, is to provide assurance to the obligee of such liability that such liability will be paid or
discharged, or that any agreements relating thereto will be complied with, or that the holders of such liability will be protected (in
whole or in part) against loss with respect thereto.
(t) Litigation. There
is no action, suit, arbitration, proceeding, inquiry or investigation before or by the Principal Market, any court, public board, other
Governmental Entity, self-regulatory organization or body pending or, to the knowledge of the Company, threatened against or affecting
the Company or any of its Subsidiaries, the Common Stock or any of the Company’s or its Subsidiaries’ officers or directors,
whether of a civil or criminal nature or otherwise, in their capacities as such. No director, officer or employee of the Company or any
of its subsidiaries has willfully violated 18 U.S.C. §1519 or engaged in spoliation in reasonable anticipation of litigation. Without
limitation of the foregoing, there has not been, and to the knowledge of the Company, there is not pending or contemplated, any investigation
by the SEC involving the Company, any of its Subsidiaries or any current or former director or officer of the Company or any of its Subsidiaries.
The SEC has not issued any stop order or other order suspending the effectiveness of any registration statement filed by the Company
under the 1933 Act or the 1934 Act. After reasonable inquiry of its employees, the Company is not aware of any fact which might result
in or form the basis for any such action, suit, arbitration, investigation, inquiry or other proceeding. Neither the Company nor any
of its Subsidiaries is subject to any order, writ, judgment, injunction, decree, determination or award of any Governmental Entity.
(u) Insurance. The
Company and each of its Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and
in such amounts as management of the Company believes to be prudent and customary in the businesses in which the Company and its Subsidiaries
are engaged. Neither the Company nor any such Subsidiary has been refused any insurance coverage sought or applied for, and neither the
Company nor any such Subsidiary has any reason to believe that it will be unable to renew its existing insurance coverage as and when
such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business at a cost that
would not have a Material Adverse Effect.
(v) Environmental Laws.
(i) The Company and its Subsidiaries (A) are in compliance with any and all Environmental Laws (as defined below), (B) have received
all permits, licenses or other approvals required of them under applicable Environmental Laws to conduct their respective businesses
and (C) are in compliance with all terms and conditions of any such permit, license or approval where, in each of the foregoing clauses
(A), (B) and (C), the failure to so comply could be reasonably expected to have, individually or in the aggregate, a Material Adverse
Effect. The term “Environmental Laws” means all federal, state, local or foreign laws relating to pollution or protection
of human health or the environment (including, without limitation, ambient air, surface water, groundwater, land surface or subsurface
strata), including, without limitation, laws relating to emissions, discharges, releases or threatened releases of chemicals, pollutants,
contaminants, or toxic or hazardous substances or wastes (collectively, “Hazardous Materials”) into the environment,
or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous
Materials, as well as all authorizations, codes, decrees, demands or demand letters, injunctions, judgments, licenses, notices or notice
letters, orders, permits, plans or regulations issued, entered, promulgated or approved thereunder.
(ii) No
Hazardous Materials:
(A) have
been disposed of or otherwise released from any Real Property (as defined below) of the Company or any of its Subsidiaries in violation
of any Environmental Laws; or
(B) are
present on, over, beneath, in or upon any Real Property or any portion thereof in quantities that would constitute a violation of any
Environmental Laws. No prior use by the Company or any of its Subsidiaries of any Real Property has occurred that violates any Environmental
Laws, which violation would have a material adverse effect on the business of the Company or any of its Subsidiaries.
(iii) Neither
the Company nor any of its Subsidiaries knows of any other person who or entity which has stored, treated, recycled, disposed of or otherwise
located on any Real Property any Hazardous Materials, including, without limitation, such substances as asbestos and polychlorinated biphenyls.
(iv) None
of the Real Properties are on any federal or state “Superfund” list or Liability Information System (“CERCLIS”)
list or any state environmental agency list of sites under consideration for CERCLIS, nor subject to any environmental related Liens.
(w) Subsidiary Rights.
The Company or one of its Subsidiaries has the unrestricted right to vote, and (subject to limitations imposed by applicable law) to
receive dividends and distributions on, all capital securities of its Subsidiaries as owned by the Company or such Subsidiary.
(x) Tax Status. The
Company and each of its Subsidiaries (i) has timely made or filed all foreign, federal and state income and all other tax returns, reports
and declarations required by any jurisdiction to which it is subject, (ii) has timely paid all taxes and other governmental assessments
and charges that are material in amount, shown or determined to be due on such returns, reports and declarations, except those being
contested in good faith and (iii) has set aside on its books provision reasonably adequate for the payment of all taxes for periods subsequent
to the periods to which such returns, reports or declarations apply. There are no unpaid taxes in any material amount claimed to be due
by the taxing authority of any jurisdiction, and the officers of the Company and its Subsidiaries know of no basis for any such claim.
The Company is not operated in such a manner as to qualify as a passive foreign investment company, as defined in Section 1297 of the
Code. The net operating loss carryforwards (“NOLs”) for United States federal income tax purposes of the consolidated
group of which the Company is the common parent, if any, shall not be adversely effected by the transactions contemplated hereby. The
transactions contemplated hereby do not constitute an “ownership change” within the meaning of Section 382 of the Code, thereby
preserving the Company’s ability to utilize such NOLs.
(y) Internal Accounting
and Disclosure Controls. The Company and each of its Subsidiaries maintains internal control over financial reporting (as such term
is defined in Rule 13a-15(f) under the 1934 Act) that is effective to provide reasonable assurance regarding the reliability of financial
reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles,
including that (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions
are recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain asset and liability accountability,
(iii) access to assets or incurrence of liabilities is permitted only in accordance with management’s general or specific authorization
and (iv) the recorded accountability for assets and liabilities is compared with the existing assets and liabilities at reasonable intervals
and appropriate action is taken with respect to any difference. The Company maintains disclosure controls and procedures (as such term
is defined in Rule 13a-15(e) under the 1934 Act) that are effective in ensuring that information required to be disclosed by the Company
in the reports that it files or submits under the 1934 Act is recorded, processed, summarized and reported, within the time periods specified
in the rules and forms of the SEC, including, without limitation, controls and procedures designed to ensure that information required
to be disclosed by the Company in the reports that it files or submits under the 1934 Act is accumulated and communicated to the Company’s
management, including its principal executive officer or officers and its principal financial officer or officers, as appropriate, to
allow timely decisions regarding required disclosure. Neither the Company nor any of its Subsidiaries has received any notice or correspondence
from any accountant, Governmental Entity or other Person relating to any potential material weakness or significant deficiency in any
part of the internal controls over financial reporting of the Company or any of its Subsidiaries.
(z) Off Balance Sheet
Arrangements. There is no transaction, arrangement, or other relationship between the Company or any of its Subsidiaries and an unconsolidated
or other off balance sheet entity that is required to be disclosed by the Company in its 1934 Act filings and is not so disclosed or
that otherwise could be reasonably likely to have a Material Adverse Effect.
(aa) Investment Company
Status. The Company is not, and upon consummation of the sale of the Securities will not be, an “investment company,”
an affiliate of an “investment company,” a company controlled by an “investment company” or an “affiliated
person” of, or “promoter” or “principal underwriter” for, an “investment company” as such terms
are defined in the Investment Company Act of 1940, as amended.
(bb) Acknowledgement Regarding
Buyers’ Trading Activity. It is understood and acknowledged by the Company that (i) following the public disclosure of the
transactions contemplated by the Transaction Documents, in accordance with the terms thereof, none of the Buyers have been asked by the
Company or any of its Subsidiaries to agree, nor has any Buyer agreed with the Company or any of its Subsidiaries, to desist from effecting
any transactions in or with respect to (including, without limitation, purchasing or selling, long and/or short) any securities of the
Company, or “derivative” securities based on securities issued by the Company or to hold any of the Securities for any specified
term; (ii) any Buyer, and counterparties in “derivative” transactions to which any such Buyer is a party, directly or indirectly,
presently may have a “short” position in the Common Stock which was established prior to such Buyer’s knowledge of
the transactions contemplated by the Transaction Documents; (iii) each Buyer shall not be deemed to have any affiliation with or control
over any arm’s length counterparty in any “derivative” transaction; and (iv) each Buyer may rely on the Company’s
obligation to timely deliver shares of Common Stock upon conversion, exercise or exchange, as applicable, of the Securities as and when
required pursuant to the Transaction Documents for purposes of effecting trading in the Common Stock of the Company. The Company further
understands and acknowledges that following the public disclosure of the transactions contemplated by the Transaction Documents pursuant
to the Press Release (as defined below) one or more Buyers may engage in hedging and/or trading activities (including, without limitation,
the location and/or reservation of borrowable shares of Common Stock) at various times during the period that the Securities are outstanding,
including, without limitation, during the periods that the value and/or number of the Warrant Common Shares or Conversion Shares, as
applicable, deliverable with respect to the Securities are being determined and such hedging and/or trading activities (including, without
limitation, the location and/or reservation of borrowable shares of Common Stock), if any, can reduce the value of the existing stockholders’
equity interest in the Company both at and after the time the hedging and/or trading activities are being conducted. The Company acknowledges
that such aforementioned hedging and/or trading activities do not constitute a breach of this Agreement, the Certificate of Designations
or any other Transaction Document or any of the documents executed in connection herewith or therewith.
(cc) Manipulation of Price.
Neither the Company nor any of its Subsidiaries has, and, to the knowledge of the Company, no Person acting on their behalf has, directly
or indirectly, (i) taken any action designed to cause or to result in the stabilization or manipulation of the price of any security
of the Company or any of its Subsidiaries to facilitate the sale or resale of any of the Securities, (ii) sold, bid for, purchased, or
paid any compensation for soliciting purchases of, any of the Securities (other than the Placement Agents), (iii) paid or agreed to pay
to any Person any compensation for soliciting another to purchase any other securities of the Company or any of its Subsidiaries or (iv)
paid or agreed to pay any Person for research services with respect to any securities of the Company or any of its Subsidiaries.
(dd) U.S. Real Property
Holding Corporation. Neither the Company nor any of its Subsidiaries is, or has ever been, and so long as any of the Securities are
held by any of the Buyers, shall become, a U.S. real property holding corporation within the meaning of Section 897 of the Code,
and the Company and each Subsidiary shall so certify upon any Buyer’s request.
(ee) Registration Eligibility.
The Company is eligible to register the Registrable Securities (defined in the Registration Rights Agreement) for resale by the Buyers
using Form S-1 promulgated under the 1933 Act.
(ff) Transfer Taxes.
On the Closing Date, all stock transfer or other taxes (other than income or similar taxes) which are required to be paid in connection
with the issuance, sale and transfer of the Securities to be sold to each Buyer hereunder will be, or will have been, fully paid or provided
for by the Company, and all laws imposing such taxes will be or will have been complied with.
(gg) Bank Holding Company
Act. Neither the Company nor any of its Subsidiaries is subject to the Bank Holding Company Act of 1956, as amended (the “BHCA”)
and to regulation by the Board of Governors of the Federal Reserve System (the “Federal Reserve”). Neither the Company
nor any of its Subsidiaries or affiliates owns or controls, directly or indirectly, five percent (5%) or more of the outstanding shares
of any class of voting securities or twenty-five percent (25%) or more of the total equity of a bank or any entity that is subject to
the BHCA and to regulation by the Federal Reserve. Neither the Company nor any of its Subsidiaries or affiliates exercises a controlling
influence over the management or policies of a bank or any entity that is subject to the BHCA and to regulation by the Federal Reserve.
(hh) Illegal or Unauthorized
Payments; Political Contributions. Neither the Company nor any of its Subsidiaries nor, to the best of the Company’s knowledge
(after reasonable inquiry of its officers and directors), any of the officers, directors, employees, agents or other representatives
of the Company or any of its Subsidiaries or any other business entity or enterprise with which the Company or any Subsidiary is or has
been affiliated or associated, has, directly or indirectly, made or authorized any payment, contribution or gift of money, property,
or services, whether or not in contravention of applicable law, (i) as a kickback or bribe to any Person or (ii) to any political organization,
or the holder of or any aspirant to any elective or appointive public office except for personal political contributions not involving
the direct or indirect use of funds of the Company or any of its Subsidiaries.
(ii) Money Laundering.
The Company and its Subsidiaries are in compliance with, and have not previously violated, the USA Patriot Act of 2001 and all other
applicable U.S. and non-U.S. anti-money laundering laws and regulations, including, without limitation, the laws, regulations and Executive
Orders and sanctions programs administered by the U.S. Office of Foreign Assets Control, including, but not limited, to (i) Executive
Order 13224 of September 23, 2001 entitled, “Blocking Property and Prohibiting Transactions With Persons Who Commit, Threaten to
Commit, or Support Terrorism” (66 Fed. Reg. 49079 (2001)); and (ii) any regulations contained in 31 CFR, Subtitle B, Chapter V.
(jj) Management. During
the past three year period, no current or former officer or director or, to the knowledge of the Company, no current ten percent (10%)
or greater stockholder of the Company or any of its Subsidiaries has been the subject of:
(i) a
petition under bankruptcy laws or any other insolvency or moratorium law or the appointment by a court of a receiver, fiscal agent or
similar officer for such Person, or any partnership in which such person was a general partner at or within two years before the filing
of such petition or such appointment, or any corporation or business association of which such person was an executive officer at or within
two years before the time of the filing of such petition or such appointment;
(ii) a
conviction in a criminal proceeding or a named subject of a pending criminal proceeding (excluding traffic violations that do not relate
to driving while intoxicated or driving under the influence);
(iii) any
order, judgment or decree, not subsequently reversed, suspended or vacated, of any court of competent jurisdiction, permanently or temporarily
enjoining any such person from, or otherwise limiting, the following activities:
(1) Acting
as a futures commission merchant, introducing broker, commodity trading advisor, commodity pool operator, floor broker, leverage transaction
merchant, any other person regulated by the United States Commodity Futures Trading Commission or an associated person of any of the foregoing,
or as an investment adviser, underwriter, broker or dealer in securities, or as an affiliated person, director or employee of any investment
company, bank, savings and loan association or insurance company, or engaging in or continuing any conduct or practice in connection with
such activity;
(2) Engaging
in any particular type of business practice; or
(3) Engaging
in any activity in connection with the purchase or sale of any security or commodity or in connection with any violation of securities
laws or commodities laws;
(iv) any
order, judgment or decree, not subsequently reversed, suspended or vacated, of any authority barring, suspending or otherwise limiting
for more than sixty (60) days the right of any such person to engage in any activity described in the preceding sub paragraph, or to be
associated with persons engaged in any such activity;
(v) a
finding by a court of competent jurisdiction in a civil action or by the SEC or other authority to have violated any securities law, regulation
or decree and the judgment in such civil action or finding by the SEC or any other authority has not been subsequently reversed, suspended
or vacated; or
(vi) a
finding by a court of competent jurisdiction in a civil action or by the Commodity Futures Trading Commission to have violated any federal
commodities law, and the judgment in such civil action or finding has not been subsequently reversed, suspended or vacated.
(kk) No Disagreements
with Accountants and Lawyers. There are no material disagreements of any kind presently existing, or reasonably anticipated by the
Company to arise, between the Company and the accountants and lawyers formerly or presently employed by the Company and the Company is
current with respect to any fees owed to its accountants and lawyers which could affect the Company’s ability to perform any of
its obligations under any of the Transaction Documents. In addition, on or prior to the date hereof, the Company had discussions with
its accountants about its financial statements previously filed with the SEC. Based on those discussions, the Company has no reason to
believe that it will need to restate any such financial statements or any part thereof.
(ll) No Disqualification
Events. With respect to Securities to be offered and sold hereunder in reliance on Rule 506(b) under the 1933 Act (“Regulation
D Securities”), none of the Company, any of its predecessors, any affiliated issuer, any director, executive officer, other
officer of the Company participating in the offering contemplated hereby, any beneficial owner of 20% or more of the Company’s
outstanding voting equity securities, calculated on the basis of voting power, nor any promoter (as that term is defined in Rule 405
under the 1933 Act) connected with the Company in any capacity at the time of sale (each, an “Issuer Covered Person”
and, together, “Issuer Covered Persons”) is subject to any of the “Bad Actor” disqualifications described
in Rule 506(d)(1)(i) to (viii) under the 1933 Act (a “Disqualification Event”), except for a Disqualification Event
covered by Rule 506(d)(2) or (d)(3). The Company has exercised reasonable care to determine whether any Issuer Covered Person is subject
to a Disqualification Event. The Company has complied, to the extent applicable, with its disclosure obligations under Rule 506(e), and
has furnished to the Buyers a copy of any disclosures provided thereunder.
(mm) Other Covered Persons.
The Company is not aware of any Person (other than the Placement Agents) that has been or will be paid (directly or indirectly) remuneration
for solicitation of Buyers or potential purchasers in connection with the sale of any Regulation D Securities.
(nn) No Additional Agreements.
The Company does not have any agreement or understanding with any Buyer with respect to the transactions contemplated by the Transaction
Documents other than as specified in the Transaction Documents.
(oo) Public Utility Holding
Act. None of the Company nor any of its Subsidiaries is a “holding company,” or an “affiliate” of a “holding
company,” as such terms are defined in the Public Utility Holding Act of 2005.
(pp) Federal Power Act.
None of the Company nor any of its Subsidiaries is subject to regulation as a “public utility” under the Federal Power Act,
as amended.
(qq) Cybersecurity.
The Company and its Subsidiaries’ information technology assets and equipment, computers, systems, networks, hardware, software,
websites, applications, and databases (collectively, “IT Systems”) are adequate for, and operate and perform in all
material respects as required in connection with the operation of the business of the Company and its subsidiaries as currently conducted,
free and clear of all material bugs, errors, defects, Trojan horses, time bombs, malware and other corruptants that would reasonably be
expected to have a Material Adverse Effect on the Company’s business. The Company and its Subsidiaries have implemented and maintained
commercially reasonable physical, technical and administrative controls, policies, procedures, and safeguards to maintain and protect
their material confidential information and the integrity, continuous operation, redundancy and security of all IT Systems and data, including
“Personal Data,” used in connection with their businesses. “Personal Data” means (i) a natural person’s
name, street address, telephone number, e-mail address, photograph, social security number or tax identification number, driver’s
license number, passport number, credit card number, bank information, or customer or account number; (ii) any information which would
qualify as “personally identifying information” under the Federal Trade Commission Act, as amended; (iii) “personal
data” as defined by the European Union General Data Protection Regulation (“GDPR”) (EU 2016/679); (iv) any information
which would qualify as “protected health information” under the Health Insurance Portability and Accountability Act of 1996,
as amended by the Health Information Technology for Economic and Clinical Health Act (collectively, “HIPAA”); and (v)
any other piece of information that allows the identification of such natural person, or his or her family, or permits the collection
or analysis of any data related to an identified person’s health or sexual orientation. There have been no breaches, violations,
outages or unauthorized uses of or accesses to same, except for those that have been remedied without material cost or liability or the
duty to notify any other person or such, nor any incidents under internal review or investigations relating to the same except in each
case, where such would not, either individually or in the aggregate, reasonably be expected to result in a Material Adverse Effect. The
Company and its Subsidiaries are presently in compliance with all applicable laws or statutes and all judgments, orders, rules and regulations
of any court or arbitrator or governmental or regulatory authority, internal policies and contractual obligations relating to the privacy
and security of IT Systems and Personal Data and to the protection of such IT Systems and Personal Data from unauthorized use, access,
misappropriation or modification except in each case, where such would not, either individually or in the aggregate, reasonably be expected
to result in a Material Adverse Effect.
(rr) Compliance with
Data Privacy Laws. The Company and its Subsidiaries are, and at all prior times were, in compliance with all applicable state and
federal data privacy and security laws and regulations, including without limitation HIPAA, and the Company and its Subsidiaries have
taken commercially reasonable actions to prepare to comply with, and since May 25, 2018, have been and currently are in compliance with,
the GDPR (EU 2016/679) (collectively, the “Privacy Laws”) except in each case, where such would not, either individually
or in the aggregate, reasonably be expected to result in a Material Adverse Effect. To ensure compliance with the Privacy Laws, the Company
and its Subsidiaries have in place, comply with, and take appropriate steps reasonably designed to ensure compliance in all material respects
with their policies and procedures relating to data privacy and security and the collection, storage, use, disclosure, handling, and analysis
of Personal Data (the “Policies”). The Company and its Subsidiaries have at all times made all disclosures to users
or customers required by applicable laws and regulatory rules or requirements, and none of such disclosures made or contained in any Policy
have, to the knowledge of the Company, been inaccurate or in violation of any applicable laws and regulatory rules or requirements in
any material respect. The Company further certifies that neither it nor any Subsidiary: (i) has received notice of any actual or potential
liability under or relating to, or actual or potential violation of, any of the Privacy Laws, and has no knowledge of any event or condition
that would reasonably be expected to result in any such notice; (ii) is currently conducting or paying for, in whole or in part, any investigation,
remediation, or other corrective action pursuant to any Privacy Law; or (iii) is a party to any order, decree, or agreement that imposes
any obligation or liability under any Privacy Law.
(ss) Absence of Certain
Changes. Since the date of the Company’s most recent audited financial statements contained in the Business Combination Registration
Statement, there has been no Material Adverse Effect on the Company and its Subsidiaries, taken as a whole. Specifically, except as set
forth on Schedule 3(ss), the date of the Company’s most recent audited financial statements contained in the Business Combination
Registration Statement, neither the Company nor its Subsidiaries have:
(i) declared,
set aside or paid any dividend or other distribution with respect to any shares of capital stock of the Company or any of its Subsidiaries
or any direct or indirect redemption, purchase or other acquisition of any such shares;
(ii) sold,
assigned, pledged, encumbered, transferred or other disposed of any tangible asset of the Company or any of its Subsidiaries (other than
sales or the licensing of its products to customers in the ordinary course of business consistent with past practice), or sold, assigned,
pledged, encumbered, transferred or other disposed of any Intellectual Property (other than licensing of products of the Company or its
Subsidiaries in the ordinary course of business and on a non-exclusive basis);
(iii) entered
into any licensing or other agreement with regard to the acquisition or disposition of any Intellectual Property other than licenses in
the ordinary course of business consistent with past practice or any amendment or consent with respect to any licensing agreement filed
or required to be filed with respect to any Governmental Entity;
(iv) capital
expenditures, individually or in the aggregate, in excess of $100,000;
(v) any
obligation or liability (whether absolute, accrued, contingent or otherwise, and whether due or to become due) incurred by the Company
or any of its Subsidiaries, in excess of $100,000 individually, other than obligations under customer contracts, current obligations and
liabilities, in each case incurred in the ordinary course of business and consistent with past practice;
(vi) any
Lien on any property of the Company or any of its Subsidiaries except for Liens in existence on the date of this Agreement that are described
on Schedule 3(ss)(vi).
(vii) any
payment, discharge, satisfaction or settlement of any suit, action, claim, arbitration, proceeding or obligation of the Company or any
of its Subsidiaries, except in the ordinary course of business and consistent with past practice;
(viii) any
split, combination or reclassification of any equity securities;
(ix) any
material loss, destruction or damage to any property of the Company or any Subsidiary, whether or not insured;
(x) any
acceleration or prepayment of any Indebtedness (as defined below) for borrowed money or the refunding of any such Indebtedness;
(xi) any
labor trouble involving the Company or any Subsidiary or any material change in their personnel or the terms and conditions of employment;
(xii) any
waiver of any valuable right, whether by contract or otherwise;
(xiii) except
as disclosed in Schedule 3(ss)(xiii), any loan or extension of credit to any officer or employee of the Company;
(xiv) any
change in the independent public accountants of the Company or its Subsidiaries or any material change in the accounting methods or accounting
practices followed by the Company or its Subsidiaries, as applicable, or any material change in depreciation or amortization policies
or rates;
(xv) any
resignation or termination of any officer, key employee or group of employees of the Company or any of its Subsidiaries;
(xvi) any
change in any compensation arrangement or agreement with any employee, officer, director or shareholder that would result in the aggregate
compensation to such Person in such year to exceed $200,000;
(xvii) any
material increase in the compensation of employees of the Company or its Subsidiaries (including any increase pursuant to any written
bonus, pension, profit sharing or other benefit or compensation plan, policy or arrangement or commitment), or any increase in any such
compensation or bonus payable to any officer, shareholder, director, consultant or agent of the Company or any of its Subsidiaries having
an annual salary or remuneration in excess of $200,000, except as may be provided in projections contained in Schedule 3(ss)(xvii);
(xviii) any
revaluation of any of their respective assets, including, without limitation, writing down the value of capitalized inventory or writing
off notes or accounts receivable or any sale of assets other than in the ordinary course of business; or
(xix) any
acquisition or disposition of any material assets (or any contract or arrangement therefor), or any other material transaction by the
Company or any Subsidiary otherwise than for fair value in the ordinary course of business.
(xx) written-down
the value of any asset of the Company or its Subsidiaries or written-off as uncollectible of any accounts or notes receivable or any portion
thereof except in the ordinary course of business and in a magnitude consistent with historical practice;
(xxi) cancelled
any debts or claims or any material amendment, termination or waiver of any rights of the Company or its Subsidiaries; or
(xxii) any
agreement, whether in writing or otherwise, to take any of the actions specified in the foregoing items (i) through (xxi).
(tt) Reserved.
(uu) Employee Matters;
Benefit Plans.
(i) Except
as set forth on Schedule 3(uu)(i), the employment of each officer and employee of the Company is terminable at the will of the Company.
The Company and its Subsidiaries have complied in all material respects with all applicable laws relating to wages, hours, equal opportunity,
collective bargaining, workers’ compensation insurance and the payment of social security and other taxes. The Company is not aware
that any officer, key employee or group of employees intends to terminate his, her or their employment with the Company or its Subsidiaries,
as the case may be, nor does the Company have a present intention, or know of a present intention of its Subsidiaries, to terminate the
employment of any officer, key employee or group of employees. There are no pending or, to the knowledge of the Company, threatened employment
discrimination charges or complaints against or involving the Company or its Subsidiaries before any federal, state, or local board, department,
commission or agency, or unfair labor practice charges or complaints, disputes or grievances affecting the Company or its Subsidiaries.
(ii) Since
the Company’s inception, neither the Company nor its Subsidiaries has experienced any labor disputes, union organization attempts
or work stoppage due to labor disagreements. There are no unfair labor practice charges or complaints against the Company or its Subsidiaries
pending, or to the knowledge of the Company, threatened before the National Labor Relations Board or any comparable state agency or authority.
There are no written or oral contracts, commitments, agreements, understandings or other arrangements with any labor organization, nor
work rules or practices agreed to with any labor organization or employee association, applicable to employees of the Company or any of
its Subsidiaries, nor is the Company or its Subsidiaries a party to, or bound by, any collective bargaining or similar agreement; there
is not, and since the Company’s inception there has not been, any representation of the employees of the Company or its Subsidiaries
by any labor organization and, to the knowledge of the Company, there are no union organizing activities among the employees of the Company
or its Subsidiaries, and to the knowledge of the Company, no question concerning representation has been raised or is threatened respecting
the employees of the Company or its Subsidiaries.
(iii) Schedule
3(uu)(iii) contains a true, correct and complete list of each pension, retirement, savings, deferred compensation and profit-sharing plan
and each stock option, stock appreciation, stock purchase, performance share, bonus or other incentive plan, severance plan, health, group
insurance or other welfare plan, or other similar plan (whether written or otherwise) and any “employee benefit plan” within
the meaning of Section 3(3) of the Employee Retirement Income Security Act of 1974, as amended (“ERISA”), under which
the Company has any current or future obligation or liability (including any potential, contingent or secondary liability under Title
IV of ERISA) or under which any employee or former employee (or beneficiary of any employee or former employee) of the Company has or
may have any current or future right to benefits (the term “plan” shall include any contract, agreement (including an employment
or independent contractor agreement), policy or understanding, each such plan being hereinafter referred to in this Agreement individually
as a “Benefit Plan”). The Company has delivered to each Buyer true, correct and complete copies of (i) each material
Benefit Plan, including any amendments thereto, (ii) the summary plan description, if any, for each Benefit Plan, including any summaries
of material modifications made since the most recent summary plan description, (iii) the latest annual report which has been filed with
the Internal Revenue Service (the “IRS”) for each Benefit Plan required to file an annual report, if any, and (iv)
the most recent IRS determination letter for each Benefit Plan that is a pension plan (as defined in ERISA) intended to be qualified under
Section 401(a) of the Code. Each Benefit Plan intended to be tax qualified under Sections 401(a) and 501(a) of the Code is and has been
determined by the IRS to be tax qualified under Sections 401(a) and 501(a) of the Code and, since such determination, no amendment to
or failure to amend any such Benefit Plan and no other event or circumstance has occurred that could reasonably be expected to adversely
affect its tax qualified status.
(iv) There
are no actions, claims, audits, lawsuits or arbitrations pending, or, to the knowledge of the Company, threatened, with respect to any
Benefit Plan or the assets of any Benefit Plan. Except as set forth in Schedule 3(uu)(iv), each Benefit Plan has been administered in
all material respects in accordance with its terms and with all applicable Legal Requirements (as defined below) (including, without limitation,
the Internal Revenue Code of 1986, as amended (the “Code”) and ERISA). “Legal Requirement” means
any federal, state, local, municipal, foreign, international, multinational, or other administrative order, constitution, law, ordinance,
principle of common law, regulation, statute, or treaty.
(v) Except
as set forth in Schedule 3(uu)(v), the consummation of the transactions contemplated by this Agreement will not (1) entitle any employee
or independent contractor of the Company or its Subsidiaries to severance pay or termination benefits, (2) accelerate the time of payment
or vesting, or increase the amount of compensation due to any current or former employee or independent contractor of the Company or its
Subsidiaries, (3) obligate the Company or any of its affiliates to pay or otherwise be liable for any compensation, vacation days, pension
contribution or other benefits to any current or former employee, consultant, agent or independent contractor of the Company or its Subsidiaries
for periods before the applicable Closing Date, (4) require assets to be set aside or other forms of security to be provided with respect
to any liability under a Benefit Plan, or (5) result in any “parachute payment” (within the meaning of Section 280G of the
Code) under any Benefit Plan.
(vi) No
Benefit Plan is subject to the provisions of Section 412 of the Code or Part 3 of Subtitle B of Title I of ERISA. No Benefit Plan is subject
to Title IV of ERISA and no Benefit Plan is a “multiemployer plan” (within the meaning of Section 3(37) of ERISA). Since inception,
neither the Company, its Subsidiaries, nor any business or entity treated as a single employer with the Company or its Subsidiaries for
purposes of Title IV of ERISA contributed to or was obliged to contribute to a pension plan that was at any time subject to Title IV of
ERISA.
(vii) No
Benefit Plan has provided, been required to provide, provides or is required to provide, at any time in the past, present, or future,
health, medical, dental, accident, disability, death or survivor benefits to or in respect of any Person beyond one year following termination
of employment, except to the extent required under any state insurance law or under Part 6 of Subtitle B of Title I of ERISA and under
Section 4980B of the Code. No Benefit Plan covers any individual that is not an employee or advisor of the Company or its Subsidiaries,
other than spouses and dependents of employees under health and child care policies listed in Schedule 3(uu)(vii), true and complete copies
of which have been made available to each Buyer.
(viii) Except
as otherwise permitted pursuant to employment agreements with the Company disclosed to the Buyers, each officer of the Company is currently
devoting all of such officer’s business time to the conduct of the business of the Company. Except as otherwise permitted pursuant
to employment agreements with the Company disclosed to the Buyers, the Company is not aware of any officer or key employee of the Company
or any of its Subsidiaries planning to work less than full time at the Company or its Subsidiaries in the future.
(vv) Assets; Title.
(i) Each
of the Company and its Subsidiaries has good and valid title to, or a valid leasehold interest in, as applicable, all of its properties
and assets, free and clear of all Liens except (i) any Lien for taxes not yet due or delinquent or being contested in good faith by appropriate
proceedings for which adequate reserves have been established in accordance with GAAP, (ii) any statutory Lien arising in the ordinary
course of business by operation of law with respect to a liability that is not yet due or delinquent, (iii) any Lien created by operation
of law, such as materialmen’s liens, mechanics’ liens and other similar liens, arising in the ordinary course of business
with respect to a liability that is not yet due or delinquent or that are being contested in good faith by appropriate proceedings, and
(iv) such as have been disposed of in the ordinary course of business. All tangible personal property owned by the Company and its t Subsidiaries
has been maintained in good operating condition and repair, except (x) for ordinary wear and tear, and (y) where such failure would not
have a Material Adverse Effect. All assets leased by the Company or any of its Subsidiaries are in the condition required by the terms
of the lease applicable thereto during the term of such lease and upon the expiration thereof. The Company and its Subsidiaries have good
and marketable title in fee simple to all real property, if any, and good and marketable title to all personal property owned by them
which is material to the business of the Company and its Subsidiaries, in each case free and clear of all liens, encumbrances and defects
except such Liens set forth in Schedule 3(vv)(i).
(ii) Schedule
3(vv)(ii) sets forth a complete list of all Real Property and interests in Real Property leased by the Company as of the date hereof (the
“Real Property”). The Company has good and valid leasehold interest in all real property and interests in real property
shown on Schedule 3(vv)(ii) to be leased by it free and clear of all Liens except where such Liens would not have a Material Adverse Effect.
Except as set forth on Schedule 3(vv)(ii), there exists no default, or any event which upon notice or the passage of time, or both, would
give rise to any default, in the performance of the Company or by any lessor under any such lease, nor, to the knowledge of the Company,
is the landlord of any such lease in default except where any such default would not have a Material Adverse Effect.
(ww) Intellectual Property.
(i) Except
as set forth on Schedule (ww)(i), the Company and its Subsidiaries own all right, title and interest in and to, or have a valid and enforceable
license to use all the Intellectual Property used by them in connection with the their respective businesses, which represents all intellectual
property rights necessary to the conduct of the their business as now conducted. The Company and its Subsidiaries are in compliance with
all contractual obligations relating to the protection of such of the Intellectual Property as they use pursuant to license or other agreement.
The conduct of the business of the Company and its Subsidiaries, to the knowledge of the Company, as currently conducted, or as reasonably
be expected to be conducted, does not, and is not reasonably expected to, conflict with or infringe any proprietary right or Intellectual
Property of any third party, including, without limitation, the transmission, reproduction, use, display or modification of any content
or material (including framing, and linking web site content) on a web site, bulletin board or other like medium hosted by or on behalf
of the Company or any of its Subsidiaries, except for such infringements and conflicts which would not reasonably be expected to have
a Material Adverse Effect. There is no claim, suit, action or proceeding pending or, to the knowledge of the Company, threatened against
the Company or any Subsidiary: (i) alleging any such conflict or infringement with any third party’s proprietary rights; or (ii)
challenging the Company’s or any Subsidiary’s ownership or use of, or the validity or enforceability of any Intellectual Property.
(ii) Schedule
(ww)(ii) sets forth a complete and current list of registered trademarks or copyrights, issued patents, applications therefor, or other
forms of Intellectual Property registration anywhere in the world that is owned by the Company or a Subsidiary (“Listed Intellectual
Property”) and the owner of record, date of application or issuance and relevant jurisdiction as to each. All Listed Intellectual
Property is owned by the Company or a Subsidiary, free and clear of security interests, liens, encumbrances or claims of any nature. All
Listed Intellectual Property is valid, subsisting, unexpired, in proper form and enforceable and all renewal fees and other maintenance
fees that have fallen due on or prior to the effective date of this Agreement have been paid. No Listed Intellectual Property is the subject
of any proceeding before any governmental, registration or other authority in any jurisdiction, including any office action or other form
of preliminary or final refusal of registration, except as noted on Schedule (ww)(ii). The consummation of the transactions contemplated
hereby will not alter or impair any Intellectual Property that is owned or licensed by the Company or a Subsidiary.
(iii) Schedule
3(ww)(iii) sets forth a complete list of all agreements relating to Intellectual Property to which the Company or a Subsidiary is a party,
subject or bound (the “Intellectual Property Contracts”) (other than agreements involving (A) the license of the Company
of standard, generally commercially available “off-the-shelf” third party products that are not and will not to any extent
be part of any product, service or intellectual property offering of the Company or (B) non-disclosure or non-use of information). Each
Intellectual Property Contract: (i) is valid and binding on the Company or a Subsidiary, as the case may be, and, to the Company’s
knowledge, the counterparties thereto, and is in full force and effect and (ii) upon consummation of the transactions contemplated hereby
shall continue in full force and effect without penalty or other adverse consequence.
(iv) The
Company and its Subsidiaries are not under any obligation to pay royalties or other payments in connection with any agreement, nor restricted
from assigning their rights respecting Intellectual Property nor will the Company or any Subsidiary otherwise be, as a result of the execution
and delivery of this Agreement or the performance of the Company’s obligations under this Agreement, in breach of any agreement
relating to the Intellectual Property.
(v) Except
as set forth on Schedule (ww)(v), no present or former employee, officer or director of the Company or any Subsidiary, or agent or outside
contractor of the Company or any Subsidiary, holds any right, title or interest, directly or indirectly, in whole or in part, in or to
any Intellectual Property that is owned or licensed by the Company or any Subsidiary.
(vi) To
the Company’s knowledge: (i) none of the Listed Intellectual Property has been used, disclosed or appropriated to the detriment
of the Company or any Subsidiary for the benefit of any Person other than the Company; and (ii) no employee, independent contractor or
agent of the Company or any Subsidiary has misappropriated any trade secrets or other confidential information of any other Person in
the course of the performance of his or her duties as an employee, independent contractor or agent of the Company or any Subsidiary.
(vii) Any
programs, modifications, enhancements or other inventions, improvements, discoveries, methods or works of authorship (“Works”)
that were created by employees of the Company or any Subsidiary were made in the regular course of such employees’ employment or
service relationships with the Company or its Subsidiary using the Company’s or the Subsidiary’s facilities and resources
and, as such, constitute either works made for hire or all rights and title to and in such Works have been fully assigned to the Company
or a Subsidiary. Each such employee who has created Works or a ny employee who in the regular course of his employment may create Works
and all consultants have signed an assignment or similar agreement with the Company or the Subsidiary confirming the Company’s or
the Subsidiary’s ownership or, in the alternate, transferring and assigning to the Company or the Subsidiary all right, title and
interest in and to such programs, modifications, enhancements or other inventions including copyright and other intellectual property
rights therein.
(viii) For
the purpose of this Agreement, “Intellectual Property” shall mean all of the following: (A) trademarks and service
marks, trade dress, product configurations, trade names and other indications of origin, applications or registrations in any jurisdiction
pertaining to the foregoing and all goodwill associated therewith; (B) inventions, discoveries, improvements, ideas, know-how, formula
methodology, processes, technology, software (including password unprotected interpretive code or source code, object code, development
documentation, programming tools, drawings, specifications and data) and applications and patents in any jurisdiction pertaining to the
foregoing, including re-issues, continuations, divisions, continuations-in-part, renewals or extensions; (C) trade secrets, including
confidential information and the right in any jurisdiction to limit the use or disclosure thereof; (D) copyrights in writings, designs
software, mask works or other works, applications or registrations in any jurisdiction for the foregoing and all moral rights related
thereto; (E) database rights; (F) internet websites, domain names and applications and registrations pertaining thereto and all intellectual
property used in connection with or contained in all versions of the Company’s Web sites; (G) rights under all agreements relating
to the foregoing; (H) books and records pertaining to the foregoing; and (I) claims or causes of action arising out of or related to past,
present or future infringement or misappropriation of the foregoing.
(xx) Books
and Records. The books of account, ledgers, order books, records and documents of the Company and its Subsidiaries accurately and
completely reflect all information relating to the respective businesses of the Company and its Subsidiaries, the nature, acquisition,
maintenance, location and collection of each of their respective assets, and the nature of all transactions giving rise to material obligations
or accounts receivable of the Company or its Subsidiaries, as the case may be, except where the failure to so reflect such information
would not have a Material Adverse Effect. The minute books of the Company and its Subsidiaries contain accurate records of all meetings
and accurately reflect all other actions taken by the shareholders, boards of directors and all committees of the boards of directors,
and other governing Persons of the Company and its Subsidiaries, respectively.
(yy) Potential Products;
FDA; EMEA.
(i) The
Company possesses all certificates, authorizations and permits issued by the appropriate federal, state or foreign regulatory authorities
necessary to conduct its business as currently conducted, including without limitation all such certificates, authorizations and permits
required by the United States Food and Drug Administration (the “FDA”) or any other federal, state or foreign agencies
or bodies engaged in the regulation of pharmaceuticals or biohazardous materials, except where the failure to so possess such certificates,
authorizations and permits, individually or in the aggregate, would not result in a Material Adverse Effect. The Company has not received
any notice of proceedings relating to the revocation or modification of any such certificate, authorization or permit which, individually
or in the aggregate, if the subject of an unfavorable decision, ruling or finding, would have a Material Adverse Effect.
(ii) The
Company has not received any written notices or statements from the FDA, the European Medicines Agency (the “EMEA”)
or any other governmental agency, and otherwise has no knowledge or reason to believe, that (i) any drug candidate of the Company (each
a “Potential Product”) may or will be rejected or determined to be non-approvable; (ii) a delay in time for review
and/or approval of a marketing authorization application or marketing approval application in any jurisdiction for any Potential Product
is or may be required, requested or being implemented; (iii) one or more clinical studies for any Potential Product shall or may be requested
or required in addition to the clinical studies submitted to the FDA prior to the date hereof as a precondition to or condition of issuance
or maintenance of a marketing approval for any Potential Product; (iv) any license, approval, permit or authorization to conduct any clinical
trial of or market any product or Potential Product of the Company has been, will be or may be suspended, revoked, modified or limited,
except in the cases of clauses (i), (ii), (iii) and (iv) where such rejections, determinations, delays, requests, suspensions, revocations,
modifications or limitations might not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect.
(iii) To
the Company’s knowledge, the preclinical and clinical testing, application for marketing approval of, manufacture, distribution,
promotion and sale of the products and Potential Products of the Company is in compliance, in all material respects, with all laws, rules
and regulations applicable to such activities, including without limitation applicable good laboratory practices, good clinical practices
and good manufacturing practices, except for such non-compliance as would not, individually or in the aggregate, have a Material Adverse
Effect. The Company is not aware of any studies, tests or trial the results of which reasonably call into question the results of the
tests and trials conducted by or on behalf of the Company. The Company has not received notice of adverse finding, warning letter or clinical
hold notice from the FDA or any non-U.S. counterpart of any of the foregoing, or any untitled letter or other correspondence or notice
from the FDA or any other governmental authority or agency or any institutional or ethical review board alleging or asserting noncompliance
with any law, rule or regulation applicable in any jurisdiction, except notices, letters, and correspondences and non-U.S. counterparts
thereof alleging or asserting such noncompliance as would not, individually or in the aggregate, have a Material Adverse Effect. The Company
has not, either voluntarily or involuntarily, initiated, conducted or issued, or caused to be initiated, conducted or issued, any recall,
field correction, market withdrawal or replacement, safety alert, warning, “dear doctor” letter, investigator notice, or other
notice or action relating to an alleged or potential lack of safety or efficacy of any product or Potential Product of the Company, any
alleged product defect of any product or Potential Product of the Company, or any violation of any material applicable law, rule, regulation
or any clinical trial or marketing license, approval, permit or authorization for any product or potential product of the Company, and
the Company is not aware of any facts or information that would cause it to initiate any such notice or action and has no knowledge or
reason to believe that the FDA, the EMEA or any other governmental agency or authority or any institutional or ethical review board or
other non-governmental authority intends to impose, require, request or suggest such notice or action.
(zz) Disclosure.
No statement made by the Company in this Agreement, any other Transaction Document or the exhibits and schedules attached hereto or in
any certificate or schedule furnished or to be furnished by or on behalf of the Company to the Investors or any of their representatives
in connection with the transactions contemplated hereby contains any untrue statement of a material fact or omits to state a material
fact necessary in order to make the statements contained herein or therein not misleading. The due diligence materials previously provided
by or on behalf of the Company to each Buyer (if any) (the “Due Diligence Materials”), have been prepared in a good
faith effort by the Company to describe the Company’s present and proposed products, and projected growth of the Company and do
not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein not misleading,
except that with respect to assumptions, projections and expressions of opinion or predictions contained in the Due Diligence Materials,
the Company represents only that such assumptions, projections, expressions of opinion and predictions were made in good faith and that
the Company believes there is a reasonable basis therefor. The Company acknowledges and agrees that no Buyer makes or has made any representations
or warranties with respect to the transactions contemplated hereby other than those specifically set forth in Section 2.
4. COVENANTS.
(a) Best Efforts.
Each Buyer shall use its best efforts to timely satisfy each of the covenants hereunder and conditions to be satisfied by it as provided
in Section 6 of this Agreement. The Company shall use its best efforts to timely satisfy each of the covenants hereunder and conditions
to be satisfied by it as provided in Section 7 of this Agreement.
(b) Form D and Blue Sky.
The Company shall file a Form D with respect to the Securities as required under Regulation D and to provide a copy thereof to each Buyer
promptly after such filing. The Company shall, on or before the Closing Date, take such action as the Company shall reasonably determine
is necessary in order to obtain an exemption for, or to, qualify the Securities for sale to the Buyers at the Closing pursuant to this
Agreement under applicable securities or “Blue Sky” laws of the states of the United States (or to obtain an exemption from
such qualification), and shall provide evidence of any such action so taken to the Buyers on or prior to the Closing Date. Without limiting
any other obligation of the Company under this Agreement, the Company shall timely make all filings and reports relating to the offer
and sale of the Securities required under all applicable securities laws (including, without limitation, all applicable federal securities
laws and all applicable “Blue Sky” laws), and the Company shall comply with all applicable foreign, federal, state and local
laws, statutes, rules, regulations and the like relating to the offering and sale of the Securities to the Buyers.
(c) Reporting Status.
Until the date on which the Buyers shall have sold all of the Registrable Securities (the “Reporting Period”), the
Company shall timely file all reports required to be filed with the SEC pursuant to the 1934 Act, and the Company shall not terminate
its status as an issuer required to file reports under the 1934 Act even if the 1934 Act or the rules and regulations thereunder would
no longer require or otherwise permit such termination; provided, however, that the requirements of this sentence shall not apply following
a Going Private Transaction (as defined in the Certificate of Designations) as long as and the Company has complied with the requirements
of such Going Private Transactions in the Certificate of Designations and Warrant. From the time Form S-3 is available to the Company
for the registration of the Registrable Securities, the Company shall take all actions necessary to maintain its eligibility to register
the Registrable Securities for resale by the Buyers on Form S-3.
(d) Use of Proceeds.
The Company will use the proceeds from the sale of the Securities for general corporate purposes, but not, directly or indirectly, for
(i) except as set forth on Schedule 3(s), the satisfaction of any indebtedness of the Company or any of its Subsidiaries, (ii) the redemption
or repurchase of any securities of the Company or any of its Subsidiaries, or (iii) the settlement of any outstanding litigation.
(e) Financial Information.
The Company agrees to send the following to each Investor (as defined in the Registration Rights Agreement) during the Reporting Period
(i) unless the following are filed with the SEC through EDGAR and are available to the public through the EDGAR system, within one (1)
Business Day after the filing thereof with the SEC, a copy of its Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, any
interim reports or any consolidated balance sheets, income statements, stockholders’ equity statements and/or cash flow statements
for any period other than annual, any Current Reports on Form 8-K and any registration statements (other than on Form S-8) or amendments
filed pursuant to the 1933 Act, (ii) unless the following are either filed with the SEC through EDGAR or are otherwise widely disseminated
via a recognized news release service (such as PR Newswire), on the same day as the release thereof, e-mail copies of all press releases
issued by the Company or any of its Subsidiaries and (iii) unless the following are filed with the SEC through EDGAR, copies of any notices
and other information made available or given to the stockholders of the Company generally, contemporaneously with the making available
or giving thereof to the stockholders.
(f) Listing. The Company
shall promptly secure the listing or designation for quotation (as the case may be) of all of the Registrable Securities upon each national
securities exchange and automated quotation system, if any, upon which the Common Stock is then listed or designated for quotation (as
the case may be) (subject to official notice of issuance) and shall maintain such listing or designation for quotation (as the case may
be) of all Registrable Securities from time to time issuable under the terms of the Transaction Documents on such national securities
exchange or automated quotation system. The Company shall maintain the Common Stock’s listing or authorization for quotation (as
the case may be) on the New York Stock Exchange, the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market or the Nasdaq
Global Select Market (each, an “Eligible Market”). Neither the Company nor any of its Subsidiaries shall take any
action which could be reasonably expected to result in the delisting or suspension of the Common Stock on an Eligible Market. The Company
shall pay all fees and expenses in connection with satisfying its obligations under this Section 4(f).
(g) Fees. The Company
shall be responsible for the payment of any placement agent’s fees, financial advisory fees, transfer agent fees, DTC (as defined
below) fees or broker’s commissions (other than for Persons engaged by any Buyer) relating to or arising out of the transactions
contemplated hereby (including, without limitation, any fees or commissions payable to the Placement Agents, who are the Company’s
only co-placement agents in connection with the transactions contemplated by this Agreement). The Company shall pay, and hold each Buyer
harmless against, any liability, loss or expense (including, without limitation, reasonable attorneys’ fees and out-of-pocket expenses)
arising in connection with any claim relating to any such payment. Except as otherwise set forth in the Transaction Documents, each party
to this Agreement shall bear its own expenses in connection with the sale of the Securities to the Buyers.
(h) Pledge of Securities.
Notwithstanding anything to the contrary contained in this Agreement, the Company acknowledges and agrees that the Securities may be
pledged by an Investor in connection with a bona fide margin agreement or other loan or financing arrangement that is secured by the
Securities. The pledge of Securities shall not be deemed to be a transfer, sale or assignment of the Securities hereunder, and no Investor
effecting a pledge of Securities shall be required to provide the Company with any notice thereof or otherwise make any delivery to the
Company pursuant to this Agreement or any other Transaction Document, including, without limitation, Section 2(g) hereof, in connection
with effecting such pledge; provided that an Investor and its pledgee shall be required to comply with the provisions of Section
2(g) hereof in order to effect a sale, transfer or assignment of Securities to such pledgee. The Company hereby agrees to execute
and deliver such documentation as a pledgee of the Securities may reasonably request in connection with a pledge of the Securities to
such pledgee by a Buyer.
(i) Disclosure of Transactions
and Other Material Information.
(i) Disclosure
of Transaction. The Company shall, on or before the Disclosure Deadline, issue a press release (the “Press Release”)
reasonably acceptable to the Buyers disclosing all the material terms of the transactions contemplated by the Transaction Documents. On
or before the Disclosure Deadline, the Company shall file a Current Report on Form 8-K describing all the material terms of the transactions
contemplated by the Transaction Documents in the form required by the 1934 Act and attaching all the material Transaction Documents (including,
without limitation, this Agreement (and all schedules to this Agreement), the form of Certificate of Designations, and the form of the
Registration Rights Agreement) (including all attachments, the “8-K Filing”). From and after the filing of the 8-K
Filing, the Company shall have disclosed all material, non-public information (if any) provided to any of the Buyers by the Company or
any of its officers, directors, employees or agents in connection with the transactions contemplated by the Transaction Documents. In
addition, effective upon the filing of the 8-K Filing, the Company acknowledges and agrees that any and all confidentiality or similar
obligations under any agreement, whether written or oral, between the Company or any of its officers, directors, affiliates, employees
or agents, on the one hand, and any of the Buyers or any of their affiliates, on the other hand, shall terminate.
(ii) Limitations
on Disclosure. The Company shall not, and the Company shall cause each of its officers, directors, employees and agents not to, provide
any Buyer with any material, non-public information regarding the Company from and after the date hereof without the express prior written
consent of such Buyer (which may be granted or withheld in such Buyer’s sole discretion). In the event of a breach of any of the
foregoing covenants, including, without limitation, Section 4(o) of this Agreement, or any of the covenants or agreements contained
in any other Transaction Document, by the Company, or any of its officers, directors, employees and agents (as determined in the reasonable
good faith judgment of such Buyer), in addition to any other remedy provided herein or in the Transaction Documents, such Buyer shall
have the right to make a public disclosure, in the form of a press release, public advertisement or otherwise, of such breach or such
material, non-public information, as applicable, without the prior approval by the Company, or any of its officers, directors, employees
or agents. No Buyer shall have any liability to the Company, or any of its officers, directors, employees, affiliates, stockholders or
agents, for any such disclosure. To the extent that the Company delivers any material, non-public information to a Buyer without such
Buyer’s consent, the Company hereby covenants and agrees that such Buyer shall not have any duty of confidentiality with respect
to, or a duty not to trade on the basis of, such material, non-public information. Subject to the foregoing, neither the Company nor any
Buyer shall issue any press releases or any other public statements with respect to the transactions contemplated hereby; provided, however,
the Company shall be entitled, without the prior approval of any Buyer, to make the Press Release and any press release or other public
disclosure with respect to such transactions (i) in substantial conformity with the 8-K Filing and contemporaneously therewith and (ii)
as is required by applicable law and regulations (provided that in the case of clause (i) each Buyer shall be consulted by the Company
in connection with any such press release or other public disclosure prior to its release). Without the prior written consent of the applicable
Buyer (which may be granted or withheld in such Buyer’s sole discretion), except as otherwise required by law, the Company shall
not (and shall cause each of its Subsidiaries and affiliates to not) disclose the name of such Buyer in any filing, announcement, release
or otherwise. Notwithstanding anything contained in this Agreement to the contrary and without implication that the contrary would otherwise
be true, each BC Party expressly acknowledges and agrees that no Buyer shall have (unless expressly agreed to by a particular Buyer after
the date hereof in a written definitive and binding agreement executed by the Company and such particular Buyer (it being understood and
agreed that no Buyer may bind any other Buyer with respect thereto)), any duty of confidentiality with respect to, or a duty not to trade
on the basis of, any material, non-public information regarding the Company.
(j) Additional Registration
Statements. Until the Applicable Date (as defined below) and at any time thereafter while any Registration Statement is not effective
or the prospectus contained therein is not available for use or any Current Public Information Failure (as defined in the Registration
Rights Agreement) exists, the Company shall not file a registration statement or an offering statement under the 1933 Act relating to
securities that are not the Registrable Securities (other than a Business Combination Registration Statement, a registration statement
on Form S-8 or such supplements or amendments to registration statements that are outstanding and have been declared effective by the
SEC as of the date hereof (solely to the extent necessary to keep such registration statements effective and available and not with respect
to any Subsequent Placement)). “Applicable Date” means the earlier of (x) the first date on which the Registration
Statement covering the resale of all of the Registrable Securities required to be covered thereby pursuant to the Registration Rights
Agreement is declared effective by the SEC (the “Registration Statement Effective Date”) (and each prospectus contained
therein is available for use on such date) or (y) the first date on which all of the Registrable Securities are eligible to be resold
by the Buyers pursuant to Rule 144 (or, if a Current Public Information Failure has occurred and is continuing, such later date after
which the Company has cured such Current Public Information Failure).
(k) Additional Issuance
of Securities. So long as any Buyer beneficially owns any Securities, the Company shall not issue any other securities that would
cause a breach or default under the Certificate of Designations. The Company agrees that for the period commencing on the date hereof
and ending on the date immediately following the 90th Trading Day after the Applicable Date (provided that such period shall
be extended by the number of calendar days during such period and any extension thereof contemplated by this proviso on which any Registration
Statement is not effective or any prospectus contained therein is not available for use or any Current Public Information Failure exists)
(the “Restricted Period”), neither the Company nor any of its Subsidiaries shall directly or indirectly issue, offer,
sell, grant any option or right to purchase, or otherwise dispose of (or announce any issuance, offer, sale, grant of any option or right
to purchase or other disposition of) any equity security or any equity-linked or related security (including, without limitation, any
“equity security” (as that term is defined under Rule 405 promulgated under the 1933 Act), any Convertible Securities (as
defined below), any debt, any preferred stock or any purchase rights) (any such issuance, offer, sale, grant, disposition or announcement
(whether occurring during the Restricted Period or at any time thereafter) is referred to as a “Subsequent Placement”);
provided, that, if this prohibition in Section 4(k) of the Original Securities Purchase Agreement is waived by the requisite Series A
Investors in accordance with the terms of such Original Securities Purchase Agreement, then it shall be deemed to have been waived by
the Buyers for purposes of this Section 4(k). Notwithstanding the foregoing, this Section 4(k) shall not apply in respect of the
issuance of (i) shares of Common Stock or standard options to purchase Common Stock to directors, officers or employees of the Company
in their capacity as such pursuant to an Approved Stock Plan (as defined below), provided that (1) all such issuances (taking into account
the shares of Common Stock issuable upon exercise of such options) after the date hereof pursuant to this clause (i) do not, in the aggregate,
exceed more than 5% of the Common Stock issued and outstanding immediately prior to the date hereof and (2) the exercise price of any
such options is not lowered, none of such options are amended to increase the number of shares issuable thereunder and none of the terms
or conditions of any such options are otherwise materially changed in any manner that adversely affects any of the Buyers; (ii) shares
of Common Stock issued upon the conversion or exercise of Convertible Securities (other than standard options to purchase Common Stock
issued pursuant to an Approved Stock Plan that are covered by clause (i) above) issued prior to the date hereof, provided that the conversion,
exercise or other method of issuance (as the case may be) of any such Convertible Security is made solely pursuant to the conversion,
exercise or other method of issuance (as the case may be) provisions of such Convertible Security that were in effect on the date immediately
prior to the date of this Agreement, the conversion, exercise or issuance price of any such Convertible Securities (other than standard
options to purchase Common Stock issued pursuant to an Approved Stock Plan that are covered by clause (i) above) is not lowered, none
of such Convertible Securities (other than standard options to purchase Common Stock issued pursuant to an Approved Stock Plan that are
covered by clause (i) above) are amended to increase the number of shares issuable thereunder and none of the terms or conditions of
any such Convertible Securities (other than standard options to purchase Common Stock issued pursuant to an Approved Stock Plan that
are covered by clause (i) above) are otherwise materially changed in any manner that adversely affects any of the Buyers; (iii) the Conversion
Shares, (iv) the Warrant Preferred Shares, (v) the Warrant Common Shares, (vi) shares of Common Stock issued pursuant to a Permitted
Equity Line, (vii) any other securities issued pursuant to the Original Securities Purchase Agreement (each of the foregoing in clauses
(i) through (vii), collectively the “Excluded Securities”), and (viii) additional shares of Preferred Stock with gross
cash proceeds not in excess of $20 million (the “Permitted Additional Preferred Shares”) and with terms and conditions
no more favorable to such purchasers than as forth in the Transaction Documents. “Approved Stock Plan” means any employee
benefit plan which has been approved by the board of directors of the Company prior to or subsequent to the date hereof pursuant to which
shares of Common Stock and standard options to purchase Common Stock may be issued to any employee, officer or director for services
provided to the Company in their capacity as such.
(l) Reservation of Shares.
So long as any of the Series B Preferred Shares remain outstanding, the Company shall take all action necessary to at all times have
authorized, and reserved for the purpose of issuance, no less than 150% of the maximum number of shares of Common Stock issuable upon
conversion of all the Series B Preferred Shares then outstanding (assuming for purposes hereof that the Series B Preferred Shares are
convertible at the Alternate Conversion Price assuming an Alternate Conversion Date as of such applicable date of determination) (the
“Required Reserve Amount”); provided that at no time shall the number of shares of Common Stock reserved pursuant
to this Section 4(l) be reduced other than proportionally in connection with any conversion and/or redemption, as applicable of
Series B Preferred Shares. If at any time the number of shares of Common Stock authorized and reserved for issuance is not sufficient
to meet the Required Reserve Amount, the Company will promptly take all corporate action necessary to authorize and reserve a sufficient
number of shares, including, without limitation, calling a special meeting of stockholders to authorize additional shares to meet the
Company’s obligations pursuant to the Transaction Documents, in the case of an insufficient number of authorized shares, obtain
stockholder approval of an increase in such authorized number of shares, and voting the management shares of the Company in favor of
an increase in the authorized shares of the Company to ensure that the number of authorized shares is sufficient to meet the Required
Reserve Amount.
(m) Conduct of Business.
The business of the Company shall not be conducted in violation of any law, ordinance or regulation of any Governmental Entity, except
where such violations would not reasonably be expected to result, either individually or in the aggregate, in a Material Adverse Effect.
(n) Other Preferred Shares;
Variable Securities. So long as any Series B Preferred Shares remain outstanding, the Company shall be prohibited from effecting
or entering into an agreement to effect any Subsequent Placement involving a Variable Rate Transaction (other than a Permitted Equity
Line (as defined below)). “Variable Rate Transaction” means a transaction in which the Company (i) issues or sells
any Convertible Securities either (A) at a conversion, exercise or exchange rate or other price that is based upon and/or varies with
the trading prices of or quotations for the shares of Common Stock at any time after the initial issuance of such Convertible Securities,
or (B) with a conversion, exercise or exchange price that is subject to being reset at some future date after the initial issuance of
such Convertible Securities or upon the occurrence of specified or contingent events directly or indirectly related to the business of
the Company or the market for the Common Stock, other than pursuant to a customary “weighted average” anti-dilution provision
or (ii) enters into any agreement (including, without limitation, an equity line of credit or an “at-the-market” offering)
whereby the Company may sell securities at a future determined price (other than standard and customary “preemptive” or “participation”
rights). Each Buyer shall be entitled to obtain injunctive relief against the Company to preclude any such issuance, which remedy shall
be in addition to any right to collect damages. “Permitted Equity Line” means the Common Stock Purchase Agreement,
by and between the Company and Keystone Capital Partners, LLC (or an affiliate thereof) (“Keystone”), dated as of
February 14, 2024 (the “Common Stock Purchase Agreement”) and, following the termination or expiration of the Common
Stock Purchase Agreement as a result of (i) the sale of shares of the maximum number of shares of Common Stock permitted to be sold thereunder,
(ii) the expiration of the three-year term thereof or (iii) to the extent such termination is expressly permitted by the terms of the
Common Stock Purchase Agreement, an equity line of credit or an “at-the-market” offering in replacement thereof. Notwithstanding
the foregoing, any waiver or amendment of Section 4(n) of the Original Securities Purchase Agreement by the requisite Series A Investors
shall be deemed to also apply to this Section 4(n).
(o) Participation Right.
[Intentionally omitted].
(p) Dilutive Issuances.
For so long as any Series B Preferred Shares remain outstanding, the Company shall not, in any manner, enter into or affect any Dilutive
Issuance (as defined in the Certificate of Designations) if the effect of such Dilutive Issuance is to cause the Company to be required
to issue upon conversion of any Series B Preferred Shares any shares of Common Stock in excess of that number of shares of Common Stock
which the Company may issue upon conversion of the Series B Preferred Shares without breaching the Company’s obligations under
the rules or regulations of the Principal Market.
(q) Passive Foreign Investment
Company. The Company shall conduct its business, and shall cause its Subsidiaries to conduct their respective businesses, in such
a manner as will ensure that the Company will not be deemed to constitute a passive foreign investment company within the meaning of
Section 1297 of the Code.
(r) Restriction on Redemption
and Cash Dividends. So long as any Series B Preferred Shares are outstanding, the Company shall not, directly or indirectly, redeem,
or declare or pay any cash dividend or distribution on, any securities of the Company without the prior express written consent of the
Buyers (other than as required by the Certificate of Designations). Notwithstanding the foregoing, any waiver or amendment of Section
4(r) of the Original Securities Purchase Agreement by the requisite Series A Investors shall be deemed to also apply to this Section
4(r).
(s) Corporate Existence.
So long as any Buyer beneficially owns any Series B Preferred Shares, the Company shall not be party to any Fundamental Transaction (as
defined in the Certificate of Designations) unless the Company is in compliance with the applicable provisions governing Fundamental
Transactions set forth in the Certificate of Designations.
(t) Stock Splits.
Until the Series B Preferred Shares are no longer outstanding, the Company shall not effect any stock combination, reverse stock split
or other similar transaction (or make any public announcement or disclosure with respect to any of the foregoing) without the prior written
consent of the Required Holders (as defined below); provided, however, that the Company may effect one (1) stock combination, reverse
stock split or other similar transaction as necessary to comply with the requirements of the Principal Market without the prior written
consent of the Required Holders. Notwithstanding the foregoing, any waiver or amendment of Section 4(t) of the Original Securities Purchase
Agreement by the requisite Series A Investors shall be deemed to also apply to this Section 4(t).
(u) Conversion
and Exercise Procedures. The form of Conversion Notice (as defined in the Certificate of Designations) included in the Certificate
of Designations set forth the totality of the procedures required of the Buyers in order to convert the Preferred Shares. Except as otherwise
provided in this Agreement or in the Certificate of Designations, no additional legal opinion, other information or instructions shall
be required of the Buyers to convert their Preferred Shares. The Company shall honor conversions of the Preferred Shares and shall deliver
the Conversion Shares in accordance with the terms, conditions and time periods set forth in the Certificate of Designations. Without
limiting the preceding sentences, no ink-original Conversion Notice shall be required, nor shall any medallion guarantee (or other type
of guarantee or notarization) of any Conversion Notice form be required in order to convert the Preferred Shares.
(v) Regulation M.
The Company will not take any action prohibited by Regulation M under the 1934 Act, in connection with the distribution of the Securities
contemplated hereby.
(w) General Solicitation.
None of the Company, any of its affiliates (as defined in Rule 501(b) under the 1933 Act) or any person acting on behalf of the Company
or such affiliate will solicit any offer to buy or offer or sell the Securities by means of any form of general solicitation or general
advertising within the meaning of Regulation D, including: (i) any advertisement, article, notice or other communication published
in any newspaper, magazine or similar medium or broadcast over television or radio; and (ii) any seminar or meeting whose attendees have
been invited by any general solicitation or general advertising.
(x) Integration. None
of the Company, any of its affiliates (as defined in Rule 501(b) under the 1933 Act), or any person acting on behalf of the Company or
such affiliate will sell, offer for sale, or solicit offers to buy or otherwise negotiate in respect of any security (as defined in the
1933 Act) which will be integrated with the sale of the Securities in a manner which would require the registration of the Securities
under the 1933 Act or require stockholder approval under the rules and regulations of the Principal Market and the Company will take
all action that is appropriate or necessary to assure that its offerings of other securities will not be integrated for purposes of the
1933 Act or the rules and regulations of the Principal Market, with the issuance of Securities contemplated hereby.
(y) Notice of Disqualification
Events. The Company will notify the Buyers in writing, prior to the Closing Date of (i) any Disqualification Event relating to any
Issuer Covered Person and (ii) any event that would, with the passage of time, become a Disqualification Event relating to any Issuer
Covered Person.
(z) Stockholder Approval.
The Company shall either (x) if the Company shall have obtained the prior written consent of the requisite stockholders (the “Stockholder
Consent”) to obtain the Stockholder Approval (as defined below), inform the stockholders of the Company of the receipt of the
Stockholder Consent by preparing and filing with the SEC, as promptly as practicable after the date hereof, but prior to the sixtieth
(60th) calendar day after the Closing Date (or, if such filing is delayed by a court or regulatory agency, in no event later
than ninety (90) calendar days after the Closing), an information statement with respect thereto or (y) provide each stockholder entitled
to vote at a special meeting of stockholders of the Company (the “Stockholder Meeting”), which shall be promptly called
and held not later than the ninetieth (90th) calendar day after the Closing Date (the “Stockholder Meeting Deadline”),
a proxy statement, in each case, in a form reasonably acceptable to the Buyers. The proxy statement, if any, shall solicit each of the
Company’s stockholder’s affirmative vote at the Stockholder Meeting for approval of resolutions (“Stockholder Resolutions”)
providing for the approval of the issuance of all of the Securities in compliance with the rules and regulations of the Principal Market
(without regard to any limitations on conversion or exercise set forth in the Preferred Shares, respectively)(such affirmative approval
being referred to herein as the “Stockholder Approval”, and the date such Stockholder Approval is obtained, the “Stockholder
Approval Date”), and the Company shall use its reasonable best efforts to solicit its stockholders’ approval of such
resolutions and to cause the Board of Directors of the Company to recommend to the stockholders that they approve such resolutions. The
Company shall be obligated to seek to obtain the Stockholder Approval by the Stockholder Meeting Deadline. If, despite the Company’s
reasonable best efforts the Stockholder Approval is not obtained on or prior to the Stockholder Meeting Deadline, the Company shall cause
an additional Stockholder Meeting to be held on or prior to the one hundred and sixtieth (160th) calendar day after the Closing
Date. If, despite the Company’s reasonable best efforts the Stockholder Approval is not obtained after such subsequent stockholder
meetings, the Company shall cause an additional Stockholder Meeting to be held semi-annually thereafter until such Stockholder Approval
is obtained. Notwithstanding the foregoing, if such Stockholder Meeting Deadline falls on a day that is not a Trading Day, then the Stockholder
Meeting Deadline shall be the next succeeding Trading Day.
(aa) No Waiver of Lock-Up
Agreement. The Company, shall not amend, waive, modify or fail to use best efforts to enforce any provision of the Investor Rights
and Lock-Up Agreement by and between the Company and the stockholders party thereto, dated February 14, 2024. For the avoidance of doubt,
no Buyer shall be a third party beneficiary of any Lock-Up Agreement. Notwithstanding the foregoing, any waiver or amendment of Section
4(aa) of the Original Securities Purchase Agreement by the requisite Series A Investors shall be deemed to also apply to this Section
4(aa).
(bb) Business Combination
Agreement Covenants. Until the Closing Date, the Company hereby covenants to each Buyer such covenants set forth in the Merger Agreement
as if such covenants were incorporated by reference into this Agreement, mutatis mutandis.
(cc) Closing Documents.
On or prior to fourteen (14) calendar days after the Closing Date, the Company agrees to deliver, or cause to be delivered, to each Buyer
a complete closing set of the executed Transaction Documents, Securities and any other document required to be delivered to any party
pursuant to Section 7 hereof or otherwise.
5. REGISTER;
TRANSFER AGENT INSTRUCTIONS; LEGEND.
(a) Register. The
Company shall maintain at its principal executive offices (or such other office or agency of the Company as it may designate by notice
to each holder of Securities), a register for the Series B Preferred Shares in which the Company shall record the name and address of
the Person in whose name the Series B Preferred Shares have been issued (including the name and address of each transferee), the aggregate
number of Series B Preferred Shares held by such Person, and the number of Conversion Shares issuable pursuant to the terms of the Series
B Preferred Shares. The Company shall keep the register open and available at all times during business hours for inspection of any Buyer
or its legal representatives.
(b) Transfer
Agent Instructions; Removal of Legends. The Company shall issue irrevocable instructions to its transfer agent and any subsequent
transfer agent (as applicable, the “Transfer Agent”) in a form reasonably acceptable to the Company and each of the
Major Buyers (the “Irrevocable Transfer Agent Instructions”) to issue certificates or credit shares, registered in
the name of a respective Buyer or its respective nominee(s), for the Conversion Shares issued from time to time to such Buyer by the Company
upon conversion of the Series B Preferred Shares in accordance with the applicable requirements of the Certificate of Designation. Upon
issuance pursuant to this Agreement, the Certificate of Designations, the Securities purchased or acquired by a Buyer in accordance with
this Agreement shall constitute “restricted securities” as such term is defined in Rule 144(a)(3) under the 1933 Act and the
certificate or book-entry statement representing such Conversion Shares shall bear the restrictive legend set forth in Section 5(c). If
a Buyer has resold Conversion Shares in a manner described under the caption “Plan of Distribution” in a then-effective and
available Registration Statement or pursuant to Rule 144 or other available exemption from registration under the 1933 Act, such Buyer
shall concurrently (a) send a confirmation to the Company and the Transfer Agent setting forth the number of such Conversion Shares (as
the case may be) that have been so resold and the date of such resales and (b) deliver to the Company, the Transfer Agent and counsel
to the Company a customary seller’s representation letter and, if requested by the Transfer Agent, a customary broker’s representation
letter confirming the resale of such Conversion Shares in the manner described above, together with any other documentation reasonably
required by the Transfer Agent and/or the Depository Trust Company (“DTC”) and, if applicable and requested by the
Company, a legal opinion of Buyer’s counsel that the sale of such Conversion Shares did not require registration under the 1933
Act, in a form and substance reasonably satisfactory to the Company and its counsel (the “Resale Deliverables”). The
Company and each Buyer hereby acknowledge that, if and when such Buyer has (i) resold Conversion Shares in a manner described under the
caption “Plan of Distribution” in the Registration Statement or pursuant to Rule 144 or other available exemption from registration
under the 1933 Act and (ii) delivered the Resale Deliverables, the Company shall instruct the Transfer Agent to cause such shares to be
credited to the applicable balance accounts at DTC as designated by such Buyer for the transferee who purchased such Conversion Shares
from such Buyer (each, a “Transferee”). Upon the written request by a Buyer to the Company if, at the time of such
request, such Buyer (i) is not, and has not been during the preceding three (3) months, an affiliate of the Company, (ii) has held the
portion of the Conversion Shares subject to such request for at least one (1) year as determined in accordance with Rule 144, (iii) all
of the other requirements of Rule 144 are satisfied, and (iv) concurrently with such request, delivers to the Company, its counsel and
the Transfer Agent a written certification that the requirements set forth in the foregoing clauses (i) through (iii) are accurate, the
Company shall, no later than one (1) Business Day following the delivery by such Buyer to the Transfer Agent of one or more legended certificates
or book-entry statements representing such Conversion Shares issued to such Buyer together with such other documentation from such Buyer
and its designated broker as the Transfer Agent or the Company deems necessary and appropriate, authorize the Transfer Agent to remove
the 1933 Act restrictive legend (and any stop transfer instructions placed against transfer of any such Conversion Shares) affixed to
the portion of such Conversion Shares for which all conditions to such Buyer’s ability to resell under Rule 144 have then been satisfied.
At the time the Company authorizes the removal of the 1933 Act restrictive legend (and any stop transfer instructions placed against transfer
of any such Conversion Shares) pursuant to this Section 5(b), the Company shall also use its commercially reasonable efforts, at its sole
expense, to cause its counsel to issue to the Transfer Agent a legal opinion or direction letter instructing the Transfer Agent that it
is authorized to remove the 1933 Act restrictive legend affixed to such Conversion Shares as contemplated by this Section 5(b) (which
legal opinion or direction letter may be delivered to the Transfer Agent in advance setting forth the conditions to the removal of such
legends). The Company shall be responsible for the fees of its Transfer Agent and any DTC fees associated with such issuance. The Company
acknowledges that a breach by it of its obligations hereunder will cause irreparable harm to a Buyer. Accordingly, the Company acknowledges
that the remedy at law for a breach of its obligations under this Section 5(b) will be inadequate and agrees, in the
event of a breach or threatened breach by the Company of the provisions of this Section 5(b), that a Buyer shall be entitled, in
addition to all other available remedies, to an order and/or injunction restraining any breach and requiring immediate issuance and transfer,
without the necessity of showing economic loss and without any bond or other security being required. Any fees (with respect to the transfer
agent, counsel to the Company or otherwise) associated with the issuance of such opinion or the removal of any legends on any of the Securities
shall be borne by the Company.
(c) Legends.
Each Buyer understands that the Securities have been issued (or will be issued in the case of the Conversion Shares) pursuant to an exemption
from registration or qualification under the 1933 Act and applicable state securities laws, and except as set forth below, the Securities
shall bear any legend as required by the “blue sky” laws of any state and a restrictive legend in substantially the following
form (and a stop-transfer order may be placed against transfer of such stock certificates):
[NEITHER THE ISSUANCE AND SALE OF THE
SECURITIES REPRESENTED BY THIS CERTIFICATE NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE [CONVERTIBLE] HAVE BEEN][THE SECURITIES
REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN] REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES
LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED EXCEPT AS PERMITTED UNDER THE ACT OR APPLICABLE STATE
SECURITIES LAWS (PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM). NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION
WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES.
(d) Failure to Timely
Deliver; Buy-In. The date by which a certificate representing the Conversion Shares (as the case may be) is required to be delivered
to such Buyer or a credit representing the shares of Common Stock is required to be made to the balance accounts designated by the selling
Buyer for its Transferee with DTC pursuant to this Agreement is referred to herein as the “Required Delivery Date,”
and the date such Conversion Shares are actually delivered without restrictive legend to such Buyer or such Buyer’s designee with
DTC, as applicable, the “Share Delivery Date.” (I) If the Company fails, for any reason or for no reason, to issue
and deliver (or cause to be delivered) by the Required Delivery Date, either (x) a certificate for the number of Conversion Shares to
a Buyer (or its permitted designee), and to which such Buyer is entitled and register such Conversion Shares on the Company’s share
register, or (y) if such Buyer has resold Conversion Shares in a manner described under the caption “Plan of Distribution”
in a then-effective and available Registration Statement or pursuant to Rule 144 or other available exemption from registration under
the 1933 Act, to credit the balance accounts designated by the selling Buyer for its Transferee with DTC for such number of Conversion
Shares submitted for legend removal by such Buyer pursuant to Section 5(b) above (the event described in the immediately foregoing
clause (I), a “Delivery Failure”); or (II) if the Registration Statement covering the resale of the Conversion Shares
is not available for the resale of such Conversion Shares and the Company fails to promptly, but in no event later than as required pursuant
to the Registration Rights Agreement, so notify such Buyer (the event described in the immediately foregoing clause (II), a “Notice
Failure”); and (III) if on or after the date of such Delivery Failure or Notice Failure, as applicable, such Buyer acquires
(in an open market transaction, stock loan or otherwise) shares of Common Stock to deliver in satisfaction of a sale by such Buyer of
shares of Common Stock submitted for legend removal by such Buyer pursuant to Section 5(b) above that such Buyer is entitled to
receive from the Company (a “Buy-In”), then the Company shall, within two (2) Trading Days after such Buyer’s
request and in such Buyer’s discretion, either (i) pay cash to such Buyer in an amount equal to such Buyer’s total purchase
price (including brokerage commissions, stock loans and other out-of-pocket expenses, if any) for the shares of Common Stock so acquired
(including, without limitation, by any other Person in respect, or on behalf, of the Holder) (the “Buy-In Price”),
at which point the Company’s obligation to so deliver such certificate or credit such Buyer’s balance account shall terminate
and such shares shall be cancelled, or (ii) promptly honor its obligation to so deliver to such Buyer a certificate or certificates or
credit the balance account designated by such Buyer for its Transferee with DTC representing such number of shares of Common Stock that
would have been so delivered if the Company timely complied with its obligations hereunder and pay cash to such Buyer in an amount equal
to the excess (if any) of the Buy-In Price over the product of (A) such number of shares of Conversion Shares that the Company was required
to deliver to such Buyer by the Required Delivery Date multiplied by (B) the lowest Closing Sale Price (as defined in the Common Warrants)
of the Common Stock on any Trading Day during the period commencing on the date of the delivery by such Buyer to the Company of the applicable
Conversion Shares and ending on the date of such delivery and payment under this clause (ii). Nothing shall limit such Buyer’s
right to pursue any other remedies available to it hereunder, at law or in equity, including, without limitation, a decree of specific
performance and/or injunctive relief with respect to the Company’s failure to timely deliver certificates representing shares of
Common Stock (or to electronically deliver such shares of Common Stock) as required pursuant to the terms hereof. Notwithstanding anything
herein to the contrary, with respect to any given Notice Failure and/or Delivery Failure, this Section 5(d) shall not apply
to the applicable Buyer the extent the Company has already paid such amounts in full to such Buyer with respect to such Notice Failure
and/or Delivery Failure, as applicable, pursuant to the analogous sections of the Certificate of Designations, with respect to the Preferred
Shares, then held by such Buyer.
6. CONDITIONS
TO THE COMPANY’S OBLIGATION TO SELL.
(a) The
obligation of the Company hereunder to issue and sell the Series B Preferred Shares to each Buyer at the Closing is subject to the satisfaction,
at or before the Closing Date, of each of the following conditions, provided that these conditions are for the Company’s sole benefit
and may be waived by the Company at any time in its sole discretion by providing each Buyer with prior written notice thereof:
(i)
Such Buyer shall have executed each of the other Transaction Documents to which it is a party and delivered the same to the Company.
(ii) Such
Buyer and each other Buyer shall have delivered to the Company the Purchase Price (less, in the case of any Buyer, the amounts withheld
pursuant to Section 4(g) and/or cancellation of such aggregate outstanding principal and accrued interest on such Purchase Price
Cancellation Notes) for the Series B Preferred Shares being purchased by such Buyer at the Closing by wire transfer of immediately available
funds in accordance with the Flow of Funds Letter.
(iii) The
representations and warranties of such Buyer shall be true and correct in all material respects as of the date when made and as of the
Closing Date as though originally made at that time (except for representations and warranties that speak as of a specific date, which
shall be true and correct as of such specific date), and such Buyer shall have performed, satisfied and complied in all material respects
with the covenants, agreements and conditions required by this Agreement to be performed, satisfied or complied with by such Buyer at
or prior to the Closing Date.
7. CONDITIONS
TO EACH BUYER’S OBLIGATION TO PURCHASE.
(a) The
obligation of each Buyer hereunder to purchase its Series B Preferred Shares at the Closing is subject to the satisfaction, at or before
the Closing Date, of each of the following conditions, provided that these conditions are for each Buyer’s sole benefit and may
be waived by such Buyer at any time in its sole discretion by providing the Company with prior written notice thereof:
(i) The
Company shall have duly executed and delivered to such Buyer each of the Transaction Documents to which it is a party and the Company
shall have duly executed and delivered to such Buyer (A) such aggregate number of Series B Preferred Shares as set forth across from such
Buyer’s name in column (3) of the Schedule of Buyers, as being purchased by such Buyer at the Closing pursuant to this Agreement.
(ii) Such
Buyer shall have received the opinion of Goodwin Procter LLP, the Company’s counsel, dated as of the Closing Date, in the form reasonably
acceptable to such Buyer.
(iii) The
Company shall have delivered to such Buyer a copy of the Irrevocable Transfer Agent Instructions, which instructions shall have been delivered
to and acknowledged in writing by the Company’s transfer agent.
(iv) The
Company shall have delivered to such Buyer a certificate executed by the Secretary of the Company and dated as of the Closing Date, as
to (i) the resolutions consistent with Section 3(b) as adopted by the Company’s board of directors in a form reasonably
acceptable to such Buyer, (ii) the Certificate of Incorporation of the Company and (iii) the Bylaws of the Company, each as in effect
at the Closing.
(v) Each
and every representation and warranty of the Company shall be true and correct as of the date when made and as of the Closing Date as
though originally made at that time (except for representations and warranties that speak as of a specific date, which shall be true and
correct as of such specific date) and the Company shall have performed, satisfied and complied in all respects with the covenants, agreements
and conditions required to be performed, satisfied or complied with by the Company at or prior to the Closing Date. Such Buyer shall have
received a certificate, duly executed by the Chief Executive Officer of the Company, dated as of the Closing Date, to the foregoing effect
and as to such other matters as may be reasonably requested by such Buyer in the form acceptable to such Buyer.
(vi) The
Common Stock (A) shall be designated for quotation or listed (as applicable) on the Principal Market and (B) shall not have been suspended,
as of the Closing Date, by the SEC or the Principal Market from trading on the Principal Market nor shall suspension by the SEC or the
Principal Market have been threatened, as of the Closing Date, either (I) in writing by the SEC or the Principal Market or (II) by falling
below the minimum maintenance requirements of the Principal Market.
(vii) The
Company shall have obtained all governmental, regulatory or third party consents and approvals, if any, necessary for the sale of the
Securities, including without limitation, those required by the Principal Market, if any.
(viii) No
statute, rule, regulation, executive order, decree, ruling or injunction shall have been enacted, entered, promulgated or endorsed by
any court or Governmental Entity of competent jurisdiction that prohibits the consummation of any of the transactions contemplated by
the Transaction Documents.
(ix) Since
the date of execution of this Agreement, no event or series of events shall have occurred that reasonably would have or result in a Material
Adverse Effect; provided, however, that the definition of “Material Adverse Effect” for the purpose of this clause (xii),
will not include any change or effect that results from (A) changes in law or interpretations thereof, or regulatory policy or interpretation,
by any Governmental Entity so long as such change does not have a disproportionate effect on the Company, (B) changes in applicable accounting
rules or principles, including changes in GAAP, so long as such change does not have a disproportionate effect on the Company, (C) changes
in general economic conditions, and events or conditions generally affecting the industries in which the Company operates, so long as
such change does not have a disproportionate effect on the Company, or (D) national or international hostilities, acts of terror or acts
of war.
(x) The
Company shall have obtained approval of the Principal Market to list or designate for quotation (as the case may be) the Conversion Shares,
the Warrant Preferred Shares and the Warrant Common Shares.
(xi) All
of the covenants, agreements and conditions required to be performed, satisfied or complied with in order for the Business Combination
Closing to occur shall have been performed, satisfied and complied with (or waived) prior to the Closing Date.
8. TERMINATION.
In the event that the Closing
shall not have occurred with respect to a Buyer on or prior to April 8, 2024, then such Buyer shall have the right to terminate its obligations
under this Agreement with respect to itself at any time on or after the close of business on such date without liability of such Buyer
to any other party; provided, however, (i) the right to terminate this Agreement under this Section 8 shall not be available
to such Buyer if the failure of the transactions contemplated by this Agreement to have been consummated by such date is the result of
such Buyer’s breach of this Agreement and (ii) the abandonment of the sale and purchase of the Series B Preferred Shares shall be
applicable only to such Buyer providing such written notice. Nothing contained in this Section 8 shall be deemed to release
any party from any liability for any breach by such party of the terms and provisions of this Agreement or the other Transaction Documents
or to impair the right of any party to compel specific performance by any other party of its obligations under this Agreement or the other
Transaction Documents.
9. MISCELLANEOUS.
(a) Governing Law; Jurisdiction;
Jury Trial. All questions concerning the construction, validity, enforcement and interpretation of this Agreement shall be governed
by the internal laws of the State of New York, without giving effect to any provision or rule (whether of the State of New York or any
other jurisdictions) that would cause the application of the laws of any jurisdictions other than the State of New York. Each of the
parties hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in The City of New York, Borough
of Manhattan, for the adjudication of any dispute hereunder or in connection herewith or under any of the other Transaction Documents
or with any transaction contemplated hereby or thereby, and hereby irrevocably waives, and agrees not to assert in any suit, action or
proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is
brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives
personal service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to
such party at the address for such notices to it under this Agreement and agrees that such service shall constitute good and sufficient
service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any
manner permitted by law. Nothing contained herein shall be deemed or operate to preclude any Buyer from bringing suit or taking other
legal action against the Company in any other jurisdiction to collect on the Company’s obligations to such Buyer or to enforce
a judgment or other court ruling in favor of such Buyer. EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE TO, AND AGREES
NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR UNDER ANY OTHER TRANSACTION DOCUMENT OR IN CONNECTION WITH
OR ARISING OUT OF THIS AGREEMENT, ANY OTHER TRANSACTION DOCUMENT OR ANY TRANSACTION CONTEMPLATED HEREBY OR THEREBY.
(b) Counterparts.
This Agreement may be executed in two or more identical counterparts, all of which shall be considered one and the same agreement and
shall become effective when counterparts have been signed by each party and delivered to the other party. In the event that any signature
is delivered by facsimile transmission or by an e-mail which contains a portable document format (.pdf) file of an executed signature
page, such signature page shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed)
with the same force and effect as if such signature page were an original thereof.
(c) Headings; Gender.
The headings of this Agreement are for convenience of reference and shall not form part of, or affect the interpretation of, this Agreement.
Unless the context clearly indicates otherwise, each pronoun herein shall be deemed to include the masculine, feminine, neuter, singular
and plural forms thereof. The terms “including,” “includes,” “include” and words of like import shall
be construed broadly as if followed by the words “without limitation.” The terms “herein,” “hereunder,”
“hereof” and words of like import refer to this entire Agreement instead of just the provision in which they are found.
(d) Severability; Maximum
Payment Amounts. If any provision of this Agreement is prohibited by law or otherwise determined to be invalid or unenforceable by
a court of competent jurisdiction, the provision that would otherwise be prohibited, invalid or unenforceable shall be deemed amended
to apply to the broadest extent that it would be valid and enforceable, and the invalidity or unenforceability of such provision shall
not affect the validity of the remaining provisions of this Agreement so long as this Agreement as so modified continues to express,
without material change, the original intentions of the parties as to the subject matter hereof and the prohibited nature, invalidity
or unenforceability of the provision(s) in question does not substantially impair the respective expectations or reciprocal obligations
of the parties or the practical realization of the benefits that would otherwise be conferred upon the parties. The parties will endeavor
in good faith negotiations to replace the prohibited, invalid or unenforceable provision(s) with a valid provision(s), the effect of
which comes as close as possible to that of the prohibited, invalid or unenforceable provision(s). Notwithstanding anything to the contrary
contained in this Agreement or any other Transaction Document (and without implication that the following is required or applicable),
it is the intention of the parties that in no event shall amounts and value paid by the Company and/or any of its Subsidiaries (as the
case may be), or payable to or received by any of the Buyers, under the Transaction Documents (including without limitation, any amounts
that would be characterized as “interest” under applicable law) exceed amounts permitted under any applicable law. Accordingly,
if any obligation to pay, payment made to any Buyer, or collection by any Buyer pursuant the Transaction Documents is finally judicially
determined to be contrary to any such applicable law, such obligation to pay, payment or collection shall be deemed to have been made
by mutual mistake of such Buyer, the Company and its Subsidiaries and such amount shall be deemed to have been adjusted with retroactive
effect to the maximum amount or rate of interest, as the case may be, as would not be so prohibited by the applicable law. Such adjustment
shall be effected, to the extent necessary, by reducing or refunding, at the option of such Buyer, the amount of interest or any other
amounts which would constitute unlawful amounts required to be paid or actually paid to such Buyer under the Transaction Documents. For
greater certainty, to the extent that any interest, charges, fees, expenses or other amounts required to be paid to or received by such
Buyer under any of the Transaction Documents or related thereto are held to be within the meaning of “interest” or another
applicable term to otherwise be violative of applicable law, such amounts shall be pro-rated over the period of time to which they relate.
(e) Entire Agreement;
Amendments. This Agreement, the other Transaction Documents and the schedules and exhibits attached hereto and thereto and the instruments
referenced herein and therein supersede all other prior oral or written agreements between the Buyers, the Company, any of their affiliates
and Persons acting on their behalf, including, without limitation, any transactions by any Buyer with respect to Common Stock or the
Securities, and the other matters contained herein and therein, and this Agreement, the other Transaction Documents, the schedules and
exhibits attached hereto and thereto and the instruments referenced herein and therein contain the entire understanding of the parties
solely with respect to the matters covered herein and therein; provided, however, nothing contained in this Agreement or any other Transaction
Document shall (or shall be deemed to) (i) have any effect on any agreements any Buyer has entered into with, or any instruments any
Buyer has received from, the Company prior to the date hereof with respect to any prior investment made by such Buyer in the Company
or (ii) waive, alter, modify or amend in any respect any obligations of the Company, or any rights of or benefits to any Buyer or any
other Person, in any agreement entered into prior to the date hereof between the Company and any Buyer, or any instruments any Buyer
received from the Company prior to the date hereof, and all such agreements and instruments shall continue in full force and effect.
Except as specifically set forth herein or therein, neither the Company nor any Buyer makes any representation, warranty, covenant or
undertaking with respect to such matters. For clarification purposes, the Recitals are part of this Agreement. No provision of this Agreement
may be amended other than by an instrument in writing signed by the Company and the Required Holders (as defined below), and any amendment
to any provision of this Agreement made in conformity with the provisions of this Section 9(e) shall be binding on all Buyers
and holders of Securities, as applicable; provided that no such amendment shall be effective to the extent that it (A) applies to less
than all of the holders of the Securities then outstanding or (B) imposes any obligation or liability on any Buyer without such Buyer’s
prior written consent (which may be granted or withheld in such Buyer’s sole discretion). No waiver shall be effective unless it
is in writing and signed by an authorized representative of the waiving party, provided that the Required Holders may waive any provision
of this Agreement, and any waiver of any provision of this Agreement made in conformity with the provisions of this Section 9(e)
shall be binding on all Buyers and holders of Securities, as applicable, provided that no such waiver shall be effective to the extent
that it (1) applies to less than all of the holders of the Securities then outstanding (unless a party gives a waiver as to itself only)
or (2) imposes any obligation or liability on any Buyer without such Buyer’s prior written consent (which may be granted or withheld
in such Buyer’s sole discretion). No consideration (other than reimbursement of legal fees) shall be offered or paid to any Person
to amend or consent to a waiver or modification of any provision of any of the Transaction Documents unless the same consideration also
is offered to all of the parties to the Transaction Documents or all holders of the Series B Preferred Shares. From the date hereof and
while any Series B Preferred Shares are outstanding, the Company shall not be permitted to receive any consideration from a Buyer or
a holder of Series B Preferred Shares that is not otherwise contemplated by the Transaction Documents in order to, directly or indirectly,
induce the Company (i) to treat such Buyer or holder of Series B Preferred Shares in a manner that is more favorable than to other similarly
situated Buyers or holders of Series B Preferred Shares, or (ii) to treat any Buyer(s) or holder(s) of Series B Preferred Shares in a
manner that is less favorable than the Buyer or holder of Series B Preferred Shares that is paying such consideration; provided, however,
that the determination of whether a Buyer has been treated more or less favorably than another Buyer shall disregard any securities of
the Company purchased or sold by any Buyer. The Company has not, directly or indirectly, made any agreements with any Buyers relating
to the terms or conditions of the transactions contemplated by the Transaction Documents except as set forth in the Transaction Documents.
Without limiting the foregoing, the Company confirms that, except as set forth in this Agreement, no Buyer has made any commitment or
promise or has any other obligation to provide any financing to the Company or otherwise. As a material inducement for each Buyer to
enter into this Agreement, the Company expressly acknowledges and agrees that (x) no due diligence or other investigation or inquiry
conducted by a Buyer, any of its advisors or any of its representatives shall affect such Buyer’s right to rely on, or shall modify
or qualify in any manner or be an exception to any of, the Company’s representations and warranties contained in this Agreement
or any other Transaction Document and (y) unless a provision of this Agreement or any other Transaction Document is expressly preceded
by the phrase “except as disclosed in the SEC Documents,” nothing contained in any of the SEC Documents shall affect such
Buyer’s right to rely on, or shall modify or qualify in any manner or be an exception to any of, the Company’s representations
and warranties contained in this Agreement or any other Transaction Document. “Required Holders” means holders of
a majority of the Registrable Securities as of such time (excluding any Registrable Securities held by the Company as of such time) (excluding
any Registrable Securities held by the Company or any of its Subsidiaries as of such time) issued or issuable hereunder or pursuant to
the Certificate of Designations (or the Buyers, with respect to any waiver or amendment of Section 4(o)).
(f) Notices. Any notices,
consents, waivers or other communications required or permitted to be given under the terms of this Agreement must be in writing and
will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt, when sent by electronic mail (provided
that such sent email is kept on file (whether electronically or otherwise) by the sending party and the sending party does not receive
an automatically generated message from the recipient’s email server that such e-mail could not be delivered to such recipient);
or (iii) one (1) Business Day after deposit with an overnight courier service with next day delivery specified, in each case, properly
addressed to the party to receive the same. The mailing addresses and e-mail addresses for such communications shall be:
If to the Company:
CERo Therapeutics Holdings, Inc.
201 Haskins Way, Suite 230
South San Francisco, CA 94080
Telephone:
Attention: Chief Executive Officer
E-Mail:
With a copy (for informational purposes only) to:
Goodwin Procter LLP
The New York Times Building
620 Eighth Avenue
New York, NY 10018
Telephone:
Attention: Jeffrey A. Letalien, Esq.
E-Mail:
If to the Transfer Agent:
Continental Stock Transfer & Trust Company
1 State Street 30th Floor
New York, NY 10004-1561
Telephone:
Attention: Luis Ortiz
E-Mail:
If to a Buyer, to its mailing address and e-mail
address set forth on the Schedule of Buyers, with copies to such Buyer’s representatives as set forth on the Schedule of Buyers.
or to such other mailing address and/or e-mail
address and/or to the attention of such other Person as the recipient party has specified by written notice given to each other party
five (5) days prior to the effectiveness of such change. Written confirmation of receipt (A) given by the recipient of such notice, consent,
waiver or other communication, (B) mechanically or electronically generated by the sender’s e-mail containing the time, date and
recipient’s e-mail or (C) provided by an overnight courier service shall be rebuttable evidence of personal service, receipt by
e-mail or receipt from an overnight courier service in accordance with clause (i), (ii) or (iii) above, respectively.
(g) Successors and Assigns.
This Agreement shall be binding upon and inure to the benefit of the parties and their respective successors and assigns, including any
purchasers of any of the Series B Preferred Shares. The Company shall not assign this Agreement or any rights or obligations hereunder
without the prior written consent of the Required Holders, including, without limitation, by way of a Fundamental Transaction (unless
the Company is in compliance with the applicable provisions governing Fundamental Transactions set forth in the Certificate of Designations).
A Buyer may assign some or all of its rights hereunder in connection with any transfer of any of its Securities without the consent of
the Company, in which event such assignee shall be deemed to be a Buyer hereunder with respect to such assigned rights.
(h) No Third Party Beneficiaries.
This Agreement is intended for the benefit of the parties hereto and their respective permitted successors and assigns, and is not for
the benefit of, nor may any provision hereof be enforced by, any other Person, other than the Indemnitees referred to in Section 9(k).
(i) Survival. The
representations, warranties, agreements and covenants shall survive the Closing. Each Buyer shall be responsible only for its own representations,
warranties, agreements and covenants hereunder.
(j) Further Assurances.
Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver all
such other agreements, certificates, instruments and documents, as any other party may reasonably request in order to carry out the intent
and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby.
(k) Indemnification.
In consideration of each Buyer’s execution and delivery of the Transaction Documents and acquiring the Securities thereunder and
in addition to all of the Company’s other obligations under the Transaction Documents, the Company shall defend, protect, indemnify
and hold harmless each Buyer and each holder of any Securities and all of their stockholders, partners, members, officers, directors,
employees and direct or indirect investors and any of the foregoing Persons’ agents or other representatives (including, without
limitation, those retained in connection with the transactions contemplated by this Agreement) (collectively, the “Indemnitees”)
from and against any and all actions, causes of action, suits, claims, losses, costs, penalties, fees, liabilities and damages, and expenses
in connection therewith (irrespective of whether any such Indemnitee is a party to the action for which indemnification hereunder is
sought), and including reasonable attorneys’ fees and disbursements (the “Indemnified Liabilities”), incurred
by any Indemnitee as a result of, or arising out of, or relating to (i) any misrepresentation or breach of any representation or warranty
made by the Company in any of the Transaction Documents, (ii) any breach of any covenant, agreement or obligation of the Company contained
in any of the Transaction Documents or (iii) any cause of action, suit, proceeding or claim brought or made against such Indemnitee by
a third party (including for these purposes a derivative action brought on behalf of the Company) or which otherwise involves such Indemnitee
that arises out of or results from (A) the execution, delivery, performance or enforcement of any of the Transaction Documents, (B) any
transaction financed or to be financed in whole or in part, directly or indirectly, with the proceeds of the issuance of the Securities,
(C) any disclosure properly made by such Buyer pursuant to Section 4(i), or (D) the status of such Buyer or holder of the Securities
either as an investor in the Company pursuant to the transactions contemplated by the Transaction Documents or as a party to this Agreement
(including, without limitation, as a party in interest or otherwise in any action or proceeding for injunctive or other equitable relief).
To the extent that the foregoing undertaking by the Company may be unenforceable for any reason, the Company shall make the maximum contribution
to the payment and satisfaction of each of the Indemnified Liabilities which is permissible under applicable law. Except as otherwise
set forth herein, the mechanics and procedures with respect to the rights and obligations under this Section 9(k) shall be
the same as those set forth in Section 6 of the Registration Rights Agreement.
(l) Construction.
The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent, and no rules
of strict construction will be applied against any party. No specific representation or warranty shall limit the generality or applicability
of a more general representation or warranty. Each and every reference to share prices, shares of Common Stock and any other numbers
in this Agreement that relate to the Common Stock shall be automatically adjusted for any stock splits, stock dividends, stock combinations,
recapitalizations or other similar transactions that occur with respect to the Common Stock after the date of this Agreement. Notwithstanding
anything in this Agreement to the contrary, for the avoidance of doubt, nothing contained herein shall constitute a representation or
warranty against, or a prohibition of, any actions with respect to the borrowing of, arrangement to borrow, identification of the availability
of, and/or securing of, securities of the Company in order for such Buyer (or its broker or other financial representative) to effect
Short Sales or similar transactions in the future.
(m) Remedies. Each
Buyer and in the event of assignment by Buyer of its rights and obligations hereunder, each holder of Securities, shall have all rights
and remedies set forth in the Transaction Documents and all rights and remedies which such holders have been granted at any time under
any other agreement or contract and all of the rights which such holders have under any law. Any Person having any rights under any provision
of this Agreement shall be entitled to enforce such rights specifically (without posting a bond or other security), to recover damages
by reason of any breach of any provision of this Agreement and to exercise all other rights granted by law. Furthermore, the Company
recognizes that in the event that it fails to perform, observe, or discharge any or all of its obligations under the Transaction Documents,
any remedy at law would inadequate relief to the Buyers. The Company therefore agrees that the Buyers shall be entitled to specific performance
and/or temporary, preliminary and permanent injunctive or other equitable relief from any court of competent jurisdiction in any such
case without the necessity of proving actual damages and without posting a bond or other security. The remedies provided in this Agreement
and the other Transaction Documents shall be cumulative and in addition to all other remedies available under this Agreement and the
other Transaction Documents, at law or in equity (including a decree of specific performance and/or other injunctive relief).
(n) Withdrawal Right.
Notwithstanding anything to the contrary contained in (and without limiting any similar provisions of) the Transaction Documents, whenever
any Buyer exercises a right, election, demand or option under a Transaction Document and the Company does not timely perform its related
obligations within the periods therein provided, then such Buyer may rescind or withdraw, in its sole discretion from time to time upon
written notice to the Company, any relevant notice, demand or election in whole or in part without prejudice to its future actions and
rights.
(o) Payment Set Aside;
Currency. To the extent that the Company makes a payment or payments to any Buyer hereunder or pursuant to any of the other Transaction
Documents or any of the Buyers enforce or exercise their rights hereunder or thereunder, and such payment or payments or the proceeds
of such enforcement or exercise or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside,
recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to the Company, a trustee, receiver or any
other Person under any law (including, without limitation, any bankruptcy law, foreign, state or federal law, common law or equitable
cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall
be revived and continued in full force and effect as if such payment had not been made or such enforcement or setoff had not occurred.
Unless otherwise expressly indicated, all dollar amounts referred to in this Agreement and the other Transaction Documents are in United
States Dollars (“U.S. Dollars”), and all amounts owing under this Agreement and all other Transaction Documents shall
be paid in U.S. Dollars. All amounts denominated in other currencies (if any) shall be converted into the U.S. Dollar equivalent amount
in accordance with the Exchange Rate on the date of calculation. “Exchange Rate” means, in relation to any amount
of currency to be converted into U.S. Dollars pursuant to this Agreement, the U.S. Dollar exchange rate as published in the Wall Street
Journal on the relevant date of calculation.
(p) Judgment Currency.
(i) If
for the purpose of obtaining or enforcing judgment against the Company in connection with this Agreement or any other Transaction Document
in any court in any jurisdiction it becomes necessary to convert into any other currency (such other currency being hereinafter in this
Section 9(p) referred to as the “Judgment Currency”) an amount due in US Dollars under this Agreement, the
conversion shall be made at the Exchange Rate prevailing on the Trading Day immediately preceding:
(1) the
date actual payment of the amount due, in the case of any proceeding in the courts of New York or in the courts of any other jurisdiction
that will give effect to such conversion being made on such date: or
(2) the
date on which the foreign court determines, in the case of any proceeding in the courts of any other jurisdiction (the date as of which
such conversion is made pursuant to this Section 9(p)(i)(2) being hereinafter referred to as the “Judgment Conversion
Date”).
(ii) If
in the case of any proceeding in the court of any jurisdiction referred to in Section 9(p)(i)(2) above, there is a change in
the Exchange Rate prevailing between the Judgment Conversion Date and the date of actual payment of the amount due, the applicable party
shall pay such adjusted amount as may be necessary to ensure that the amount paid in the Judgment Currency, when converted at the Exchange
Rate prevailing on the date of payment, will produce the amount of US Dollars which could have been purchased with the amount of Judgment
Currency stipulated in the judgment or judicial order at the Exchange Rate prevailing on the Judgment Conversion Date.
(iii) Any
amount due from the Company under this provision shall be due as a separate debt and shall not be affected by judgment being obtained
for any other amounts due under or in respect of this Agreement or any other Transaction Document.
(q) Independent Nature
of Buyers’ Obligations and Rights. The obligations of each Buyer under the Transaction Documents are several and not joint
with the obligations of any other Buyer, and no Buyer shall be responsible in any way for the performance of the obligations of any other
Buyer under any Transaction Document. Nothing contained herein or in any other Transaction Document, and no action taken by any Buyer
pursuant hereto or thereto, shall be deemed to constitute the Buyers as, and the Company acknowledges that the Buyers do not so constitute,
a partnership, an association, a joint venture or any other kind of group or entity, or create a presumption that the Buyers are in any
way acting in concert or as a group or entity, and the Company shall not assert any such claim with respect to such obligations or the
transactions contemplated by the Transaction Documents or any matters, and the Company acknowledges that the Buyers are not acting in
concert or as a group, and the Company shall not assert any such claim, with respect to such obligations or the transactions contemplated
by the Transaction Documents. The decision of each Buyer to purchase Securities pursuant to the Transaction Documents has been made by
such Buyer independently of any other Buyer. Each Buyer acknowledges that no other Buyer has acted as agent for such Buyer in connection
with such Buyer making its investment hereunder and that no other Buyer will be acting as agent of such Buyer in connection with monitoring
such Buyer’s investment in the Securities or enforcing its rights under the Transaction Documents. The Company and each Buyer confirms
that each Buyer has independently participated with the Company in the negotiation of the transaction contemplated hereby with the advice
of its own counsel and advisors. Each Buyer shall be entitled to independently protect and enforce its rights, including, without limitation,
the rights arising out of this Agreement or out of any other Transaction Documents, and it shall not be necessary for any other Buyer
to be joined as an additional party in any proceeding for such purpose. The use of a single agreement to effectuate the purchase and
sale of the Securities contemplated hereby was solely in the control of the Company, not the action or decision of any Buyer, and was
done solely for the convenience of the Company and not because it was required or requested to do so by any Buyer. It is expressly understood
and agreed that each provision contained in this Agreement and in each other Transaction Document is between the Company and a Buyer,
solely, and not between the Company, its Subsidiaries and the Buyers collectively and not between and among the Buyers.
[signature pages follow]
IN WITNESS WHEREOF,
each Buyer and the Company have caused their respective signature page to this Agreement to be duly executed as of the date first written
above.
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COMPANY: |
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CERo THERAPEUTICS HOLDINGS, INC. |
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By: |
/s/ Charles Carter |
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Name: |
Charles Carter |
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Title: |
Chief Financial Officer |
IN WITNESS WHEREOF,
each Buyer and the Company have caused their respective signature page to this Agreement to be duly executed as of the date first written
above.
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BUYER: |
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[BUYERS] |
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By: |
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Name: |
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Title: |
Exhibit 10.14
REGISTRATION RIGHTS AGREEMENT
This REGISTRATION RIGHTS
AGREEMENT (this “Agreement”), dated as of March 28, 2024, is by and among CERo Therapeutics Holdings, Inc., a Delaware
corporation with offices located at 201 Haskins Way, Suite 230, South San Francisco, CA 94080 (the “Company”), and
the undersigned buyers (each, a “Buyer,” and collectively, the “Buyers”).
RECITALS
A. In
connection with the Securities Purchase Agreement by and among the parties hereto, dated as of March 28, 2024 (the “Securities
Purchase Agreement”), the Company has agreed, upon the terms and subject to the conditions of the Securities Purchase Agreement,
to issue and sell to each Buyer the Series B Preferred Shares (as defined in the Securities Purchase Agreement) which will be convertible
into Conversion Shares (as defined in the Securities Purchase Agreement) in accordance with the terms of the Certificate of Designations
(as defined in the Securities Purchase Agreement).
B. To
induce the Buyers to consummate the transactions contemplated by the Securities Purchase Agreement, the Company has agreed to provide
certain registration rights under the Securities Act of 1933, as amended, and the rules and regulations thereunder, or any similar successor
statute (collectively, the “1933 Act”), and applicable state securities laws.
AGREEMENT
NOW, THEREFORE, in
consideration of the premises and the mutual covenants contained herein and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Company and each of the Buyers hereby agree as follows:
Capitalized terms used herein
and not otherwise defined herein shall have the respective meanings set forth in the Securities Purchase Agreement. As used in this Agreement,
the following terms shall have the following meanings:
(a) “Business
Day” means any day other than Saturday, Sunday or other day on which commercial banks in The City of New York are authorized
or required by law to remain closed; provided, however, for clarification, commercial
banks shall not be deemed to be authorized or required by law to remain closed due to “stay at home”, “shelter-in-place”,
“non-essential employee” or any other similar orders or restrictions or the closure of any physical branch locations
at the direction of any governmental authority so long as the electronic funds transfer systems (including for wire transfers) of commercial
banks in The City of New York generally are open for use by customers on such day.
(b) “Closing
Date” shall have the meaning set forth in the Securities Purchase Agreement.
(c) “Effective
Date” means the date that the applicable Registration Statement has been declared effective by the SEC.
(d) “Effectiveness
Deadline” means (i) with respect to the initial Registration Statement required to be filed pursuant to Section 2(a), the
earlier of the (A) seventy-fifth (75th) calendar day after the Closing Date and (B) third (3rd) Business Day after
the date the Company is notified (orally or in writing, whichever is earlier) by the SEC that such Registration Statement will not be
reviewed or will not be subject to further review and (ii) with respect to any additional Registration Statements that may be required
to be filed by the Company pursuant to this Agreement, the earlier of the (A) sixtieth (60th) calendar day following the date
on which the Company was required to file such additional Registration Statement and (B) third (3rd) Business Day after the
date the Company is notified (orally or in writing, whichever is earlier) by the SEC that such Registration Statement will not be reviewed
or will not be subject to further review.
(e) “Filing
Deadline” means (i) with respect to the initial Registration Statement required to be filed pursuant to Section 2(a), the
forty-fifth (45th) calendar day after the Closing Date and (ii) with respect to any additional Registration Statements
that may be required to be filed by the Company pursuant to this Agreement, the date on which the Company was required to file such additional
Registration Statement pursuant to the terms of this Agreement.
(f) “Investor”
means a Buyer or any transferee or assignee of any Registrable Securities or Series B Preferred Shares, as applicable, to whom a Buyer
assigns its rights under this Agreement and who agrees to become bound by the provisions of this Agreement in accordance with Section 9
and any transferee or assignee thereof to whom a transferee or assignee of any Registrable Securities or Series B Preferred Shares, as
applicable, assigns its rights under this Agreement and who agrees to become bound by the provisions of this Agreement in accordance with
Section 9.
(g) “Person”
means an individual, a limited liability company, a partnership, a joint venture, a corporation, a trust, an unincorporated organization
or a government or any department or agency thereof.
(h) “register,”
“registered,” and “registration” refer to a registration effected by preparing and filing one or
more Registration Statements in compliance with the 1933 Act and pursuant to Rule 415 and the declaration of effectiveness of such Registration
Statement(s) by the SEC.
(i) “Registrable
Securities” means (i) the Conversion Shares and (ii) any capital stock of the Company issued or issuable with respect to the
Conversion Shares, or the Series B Preferred Shares, including, without limitation, (1) as a result of any stock split, stock dividend,
recapitalization, exchange or similar event or otherwise and (2) shares of capital stock of the Company into which the shares of Common
Stock (as defined in the Certificate of Designations) are converted or exchanged and shares of capital stock of a Successor Entity (as
defined in the Common Warrants) into which the shares of Common Stock are converted or exchanged, in each case, without regard to any
limitations on conversion of the Series B Preferred Shares.
(j) “Registration
Statement” means a registration statement or registration statements of the Company filed under the 1933 Act covering Registrable
Securities.
(k) “Resale
Eligibility Conditions” means the following conditions: such Buyer has (i) resold shares of Common Stock in a manner described
under the caption “Plan of Distribution” in the Registration Statement or pursuant to Rule 144 or other available exemption
from registration under the 1933 Act and (ii) delivered to the Company, the Transfer Agent (as defined in the Securities Purchase Agreement)
and counsel to the Company a customary seller’s representation letter and, if requested by the Transfer Agent, a customary broker’s
representation letter confirming the resale of such shares of Common Stock in the manner described above, together with any other documentation
reasonably required by the Transfer Agent and/or the Depository Trust Company and, if applicable and requested by the Company, a legal
opinion of Buyer’s counsel that the sale of such shares of Common Stock did not require registration under the 1933 Act, in a form
and substance reasonably satisfactory to the Company and its counsel.
(l) “Required
Holders” shall have the meaning as set forth in the Securities Purchase Agreement.
(m) “Required
Registration Amount” means, as of any time of determination, the sum of 200% of the maximum number of Conversion Shares issuable
upon conversion of the Series B Preferred Shares (assuming for purposes hereof that (x) the Series B Preferred Shares are convertible
at the Alternate Conversion Price (as defined in the Certificate of Designations) assuming an Alternate Conversion Date (as defined in
the Certificate of Designations) as of such date of determination, and (y) any such conversion shall not take into account any limitations
on the conversion of the Series B Preferred Shares set forth in the Certificate of Designations).
(n) “Rule
144” means Rule 144 promulgated by the SEC under the 1933 Act, as such rule may be amended from time to time, or any other similar
or successor rule or regulation of the SEC that may at any time permit the Investors to sell securities of the Company to the public without
registration.
(o) “Rule
415” means Rule 415 promulgated by the SEC under the 1933 Act, as such rule may be amended from time to time, or any other similar
or successor rule or regulation of the SEC providing for offering securities on a continuous or delayed basis.
(p) “SEC”
means the United States Securities and Exchange Commission or any successor thereto.
(a) Mandatory
Registration. The Company shall prepare and, as soon as practicable, but in no event later than the Filing Deadline, file with the
SEC an initial Registration Statement on Form S-3 covering the resale of all of the Registrable Securities, provided that such initial
Registration Statement shall register for resale at least the number of shares of Common Stock equal to the Required Registration Amount
as of the date such Registration Statement is initially filed with the SEC; provided further that if Form S-3 is unavailable for such
a registration, the Company shall use such other form as is required by Section 2(c). Such initial Registration Statement, and each other
Registration Statement required to be filed pursuant to the terms of this Agreement, shall include the information set forth in (except
if otherwise directed by the Required Holders) the “Selling Stockholders” and “Plan of Distribution”
sections in substantially the form attached hereto as Exhibit B. The Company shall use its best efforts to have such initial Registration
Statement, and each other Registration Statement required to be filed pursuant to the terms of this Agreement, declared effective by the
SEC as soon as practicable, but in no event later than the applicable Effectiveness Deadline for such Registration Statement.
(b) Legal
Counsel. [Intentionally Omitted].
(c) Ineligibility
to Use Form S-3. In the event that Form S-3 is not available for the registration of the resale of Registrable Securities hereunder,
the Company shall (i) register the resale of the Registrable Securities on Form S-1 or another appropriate form reasonably acceptable
to the Required Holders and (ii) undertake to register the resale of the Registrable Securities on Form S-3 as soon as such form
is available, provided that the Company shall maintain the effectiveness of all Registration Statements then in effect until such time
as a Registration Statement on Form S-3 covering the resale of all the Registrable Securities has been declared effective by the SEC and
the prospectus contained therein is available for use.
(d) Sufficient
Number of Shares Registered. In the event the number of shares available under any Registration Statement is insufficient to cover
all of the Registrable Securities required to be covered by such Registration Statement or an Investor’s allocated portion of the
Registrable Securities pursuant to Section 2(h), the Company shall amend such Registration Statement (if permissible), or file with
the SEC a new Registration Statement (on the short form available therefor, if applicable), or both, so as to cover at least the Required
Registration Amount as of the Trading Day immediately preceding the date of the filing of such amendment or new Registration Statement,
in each case, as soon as practicable, but in any event not later than fifteen (15) days (or twenty (20) Trading Days with respect to financial
statement comments) after the necessity therefor arises (but taking account of any Staff position with respect to the date on which the
Staff will permit such amendment to the Registration Statement and/or such new Registration Statement (as the case may be) to be filed
with the SEC). The Company shall use its best efforts to cause such amendment to such Registration Statement and/or such new Registration
Statement (as the case may be) to become effective as soon as practicable following the filing thereof with the SEC, but in no event later
than the applicable Effectiveness Deadline for such Registration Statement. For purposes of the foregoing provision, the number of shares
available under a Registration Statement shall be deemed “insufficient to cover all of the Registrable Securities” if at any
time the number of shares of Common Stock available for resale under the applicable Registration Statement is less than the product determined
by multiplying (i) the Required Registration Amount as of such time by (ii) 0.90. The calculation set forth in the foregoing sentence
shall be made without regard to any limitations on conversion, amortization and/or redemption of the Series B Preferred Shares or exercise
of the Common Warrants (and such calculation shall assume (A) that the Series B Preferred Shares are then convertible in full into shares
of Common Stock at the then prevailing Conversion Rate (as defined in the Certificate of Designations) and (B) the initial outstanding
principal amount of the Series B Preferred Shares remains outstanding through the scheduled Maturity Date (as defined in the Certificate
of Designations) and no redemptions of the Series B Preferred Shares occur prior to the scheduled Maturity Date.
(e) Effect
of Failure to File and Obtain and Maintain Effectiveness of any Registration Statement. If (i) a Registration Statement covering the
resale of all of the Registrable Securities required to be covered thereby (disregarding any reduction pursuant to Section 2(f))
and required to be filed by the Company pursuant to this Agreement is (A) not filed with the SEC on or before the Filing Deadline for
such Registration Statement (a “Filing Failure”) (it being understood that if the Company files a Registration Statement
without affording each Investor the opportunity to review and comment on the same as required by Section 3(c) hereof, the Company
shall be deemed to not have satisfied this clause (i)(A) and such event shall be deemed to be a Filing Failure) or (B) not declared
effective by the SEC on or before the Effectiveness Deadline for such Registration Statement (an “Effectiveness Failure”)
(it being understood that if on the first (1st) Business Day immediately following the Effective Date for such Registration
Statement the Company shall not have filed a “final” prospectus for such Registration Statement with the SEC under Rule 424(b)
in accordance with Section 3(b) (whether or not such a prospectus is technically required by such rule), the Company shall be deemed
to not have satisfied this clause (i)(B) and such event shall be deemed to be an Effectiveness Failure), (ii) other than during an Allowable
Grace Period (as defined below), on any day after the Effective Date of a Registration Statement sales of all of the Registrable Securities
required to be included on such Registration Statement (disregarding any reduction pursuant to Section 2(f)) cannot be made pursuant
to such Registration Statement (including, without limitation, because of a failure to keep such Registration Statement effective, a failure
to disclose such information as is necessary for sales to be made pursuant to such Registration Statement, a suspension or delisting of
(or a failure to timely list) the shares of Common Stock on the Principal Market (as defined in the Securities Purchase Agreement) or
any other limitations imposed by the Principal Market, or a failure to register a sufficient number of shares of Common Stock or by reason
of a stop order) or the prospectus contained therein is not available for use for any reason (a “Maintenance Failure”),
or (iii) if a Registration Statement is not effective for any reason or the prospectus contained therein is not available for use for
any reason, and either (x) the Company fails for any reason to satisfy the requirements of Rule 144(c)(1), including, without limitation,
the failure to satisfy the current public information requirement under Rule 144(c) or (y) the Company has ever been an issuer described
in Rule 144(i)(1)(i) or becomes such an issuer in the future, and the Company shall fail to satisfy any condition set forth in Rule 144(i)(2)
(a “Current Public Information Failure”) as a result of which any of the Investors are unable to sell Registrable Securities
without restriction under Rule 144 (including, without limitation, volume restrictions), then, as partial relief for the damages
to any holder by reason of any such delay in, or reduction of, its ability to sell the underlying shares of Common Stock (which remedy
shall not be exclusive of any other remedies available at law or in equity, including, without limitation, specific performance), the
Company shall pay to each holder of Registrable Securities relating to such Registration Statement an amount in cash equal to one percent
(1%) of such Investor’s Purchase Price (as defined in the Securities Purchase Agreement) (1) on the date of such Filing Failure,
Effectiveness Failure, Maintenance Failure or Current Public Information Failure, as applicable, and (2) on every thirty (30) day anniversary
of (I) a Filing Failure until such Filing Failure is cured; (II) an Effectiveness Failure until such Effectiveness Failure is cured; (III) a
Maintenance Failure until such Maintenance Failure is cured; and (IV) a Current Public Information Failure until the earlier of (i) the
date such Current Public Information Failure is cured and (ii) such time that such public information is no longer required pursuant to
Rule 144 (in each case, pro rated for periods totaling less than thirty (30) days); provided that the total amount of any Registration
Delay Payments (as defined below) shall not exceed 10% of such Investor’s Purchase Price. The payments to which a holder of Registrable
Securities shall be entitled pursuant to this Section 2(e) are referred to herein as “Registration Delay Payments.”
Following the initial Registration Delay Payment for any particular event or failure (which shall be paid on the date of such event or
failure, as set forth above), without limiting the foregoing, if an event or failure giving rise to the Registration Delay Payments is
cured prior to any thirty (30) day anniversary of such event or failure, then such Registration Delay Payment shall be made on the third
(3rd) Business Day after such cure. In the event the Company fails to make Registration Delay Payments in a timely manner in
accordance with the foregoing, such Registration Delay Payments shall bear interest at the rate of one percent (1%) per month (prorated
for partial months) until paid in full. Notwithstanding the foregoing, no Registration Delay Payments shall be owed to an Investor (other
than with respect to a Maintenance Failure resulting from a suspension or delisting of (or a failure to timely list) the shares of Common
Stock on the Principal Market) with respect to any period during which all of such Investor’s Registrable Securities may be sold
by such Investor without restriction under Rule 144 (including, without limitation, volume restrictions) and without the need for current
public information required by Rule 144(c)(1) (or Rule 144(i)(2), if applicable).
(f) Offering.
Notwithstanding anything to the contrary contained in this Agreement, but subject to the payment of the Registration Delay Payments pursuant
to Section 2(e), in the event the staff of the SEC (the “Staff”) or the SEC seeks to characterize any offering
pursuant to a Registration Statement filed pursuant to this Agreement as constituting an offering of securities by, or on behalf
of, the Company, or in any other manner, such that the Staff or the SEC do not permit such Registration Statement to become
effective and used for resales in a manner that does not constitute such an offering and that permits the continuous resale at the market
by the Investors participating therein (or as otherwise may be acceptable to each Investor) without being named therein as an
“underwriter,” then the Company shall reduce the number of shares to be included in such Registration Statement by all Investors
until such time as the Staff and the SEC shall so permit such Registration Statement to become effective as aforesaid. In making
such reduction, the Company shall reduce the number of shares to be included by all Investors on a pro rata basis (based upon the number
of Registrable Securities otherwise required to be included for each Investor) unless the inclusion of shares by a particular Investor
or a particular set of Investors are resulting in the Staff or the SEC’s “by or on behalf of the Company” offering position,
in which event the shares held by such Investor or set of Investors shall be the only shares subject to reduction (and if by a set of
Investors on a pro rata basis by such Investors or on such other basis as would result in the exclusion of the least number of shares
by all such Investors); provided, that, with respect to such pro rata portion allocated to any Investor, such Investor may elect the allocation
of such pro rata portion among the Registrable Securities of such Investor. In addition, in the event that the Staff or the SEC requires
any Investor seeking to sell securities under a Registration Statement filed pursuant to this Agreement to be specifically identified
as an “underwriter” in order to permit such Registration Statement to become effective, and such Investor does not consent
to being so named as an underwriter in such Registration Statement, then, in each such case, the Company shall reduce the total
number of Registrable Securities to be registered on behalf of such Investor, until such time as the Staff or the SEC does
not require such identification or until such Investor accepts such identification and the manner thereof. Any reduction pursuant to this
paragraph will first reduce all Registrable Securities other than those issued pursuant to the Securities Purchase Agreement. In
the event of any reduction in Registrable Securities pursuant to this paragraph, an affected Investor shall have the right to
require, upon delivery of a written request to the Company signed by such Investor, the Company to file a registration statement within
twenty (20) days of such request (subject to any restrictions imposed by Rule 415 or required by the Staff or the SEC) for resale
by such Investor in a manner reasonably acceptable to such Investor, and the Company shall following such request cause to be and
keep effective such registration statement in the same manner as otherwise contemplated in this Agreement for registration statements
hereunder, in each case until such time as: (i) all Registrable Securities held by such Investor have been registered and sold pursuant
to an effective Registration Statement in a manner acceptable to such Investor or (ii) all Registrable Securities may be resold by
such Investor without restriction (including, without limitation, volume limitations) pursuant to Rule 144 (taking account of any
Staff position with respect to “affiliate” status) and without the need for current public information required by Rule 144(c)(1)
(or Rule 144(i)(2), if applicable) or (iii) such Investor agrees to be named as an underwriter in any such Registration Statement in a
manner acceptable to such Investor as to all Registrable Securities held by such Investor and that have not theretofore been included
in a Registration Statement under this Agreement (it being understood that the special demand right under this sentence may be exercised
by an Investor multiple times and with respect to limited amounts of Registrable Securities in order to permit the resale thereof by such
Investor as contemplated above).
(g) Piggyback
Registrations. Without limiting any obligation of the Company hereunder or under the Securities Purchase Agreement, if there is not
an effective Registration Statement covering all of the Registrable Securities or the prospectus contained therein is not available for
use and the Company shall determine to prepare and file with the SEC a registration statement or offering statement relating to an offering
for its own account or the account of others under the 1933 Act of any of its equity securities (other than on Form S-4 or Form S-8 (each
as promulgated under the 1933 Act) or their then equivalents relating to equity securities to be issued solely in connection with any
acquisition of any entity or business or equity securities issuable in connection with the Company’s stock option or other employee
benefit plans), then the Company shall deliver to each Investor a written notice of such determination and, if within fifteen (15)
days after the date of the delivery of such notice, any such Investor shall so request in writing, the Company shall include in such registration
statement or offering statement all or any part of such Registrable Securities such Investor requests to be registered; provided, however,
the Company shall not be required to register any Registrable Securities pursuant to this Section 2(g) that are eligible for resale
pursuant to Rule 144 without restriction (including, without limitation, volume restrictions) and without the need for current public
information required by Rule 144(c)(1) (or Rule 144(i)(2), if applicable) or that are the subject of a then-effective Registration
Statement.
(h) Allocation
of Registrable Securities. The initial number of Registrable Securities included in any Registration Statement and any increase in
the number of Registrable Securities included therein shall be allocated pro rata among the Investors based on the number of Registrable
Securities held by each Investor at the time such Registration Statement covering such initial number of Registrable Securities or increase
thereof is declared effective by the SEC. In the event that an Investor sells or otherwise transfers any of such Investor’s Registrable
Securities, each transferee or assignee (as the case may be) that becomes an Investor shall be allocated a pro rata portion of the then-remaining
number of Registrable Securities included in such Registration Statement for such transferor or assignee (as the case may be). Any shares
of Common Stock included in a Registration Statement and which remain allocated to any Person which ceases to hold any Registrable Securities
covered by such Registration Statement shall be allocated to the remaining Investors, pro rata based on the number of Registrable Securities
then held by such Investors which are covered by such Registration Statement.
(i) No
Inclusion of Other Securities. The Company shall in no event include any securities other than such securities described on Schedule
3(i) attached hereto (the “Additional Shares”) and Registrable Securities on any Registration Statement filed in accordance
herewith without the prior written consent of the Required Holders; provided, that if the SEC shall require the Company (or a reduction
is otherwise necessary to prevent one or more Investors being named as an underwriter therein) to reduce the aggregate number of shares
of Common Stock registered on any Registration Statement that includes both Registrable Securities and Additional Shares, all of the Additional
Shares shall be excluded before any of the aggregate number of Registrable Securities to be registered on such Registration Statement
shall be reduced. Until the Applicable Date (as defined in the Securities Purchase Agreement), the Company shall not enter into any agreement
providing any registration rights to any of its security holders, except as otherwise permitted under the Securities Purchase Agreement.
The Company shall use its
best efforts to effect the registration of the Registrable Securities in accordance with the intended method of disposition thereof, and,
pursuant thereto, the Company shall have the following obligations:
(a) The
Company shall promptly prepare and file with the SEC a Registration Statement with respect to all the Registrable Securities (but in no
event later than the applicable Filing Deadline) and use its best efforts to cause such Registration Statement to become effective as
soon as practicable after such filing (but in no event later than the Effectiveness Deadline). Subject to Allowable Grace Periods, the
Company shall keep each Registration Statement effective (and the prospectus contained therein available for use) pursuant to Rule 415
for resales by the Investors on a delayed or continuous basis at then-prevailing market prices (and not fixed prices) at all times until
the earlier of (i) the date as of which all of the Investors may sell all of the Registrable Securities required to be covered by such
Registration Statement (disregarding any reduction pursuant to Section 2(f)) without restriction pursuant to Rule 144 (including,
without limitation, volume restrictions) and without the need for current public information required by Rule 144(c)(1) (or Rule 144(i)(2),
if applicable) or (ii) the date on which the Investors shall have sold all of the Registrable Securities covered by such Registration
Statement (the “Registration Period”). Notwithstanding anything to the contrary contained in this Agreement, the Company
shall ensure that, when filed and at all times while effective, each Registration Statement (including, without limitation, all amendments
and supplements thereto) and the prospectus (including, without limitation, all amendments and supplements thereto) used in connection
with such Registration Statement (1) shall not contain any untrue statement of a material fact or omit to state a material fact required
to be stated therein, or necessary to make the statements therein (in the case of prospectuses, in the light of the circumstances in which
they were made) not misleading and (2) will disclose (whether directly or through incorporation by reference to other SEC filings to the
extent permitted) all material information regarding the Company and its securities. The Company shall submit to the SEC, as promptly
as practicable after the date that the Company learns that no review of a particular Registration Statement will be made by the Staff
or that the Staff has no further comments on a particular Registration Statement (as the case may be).a request for acceleration of effectiveness
of such Registration Statement to a time and date not later than forty-eight (48) hours after the submission of such request. The
Company shall respond in writing to comments made by the SEC in respect of a Registration Statement as soon as practicable, but in no
event later than fifteen (15) days (or twenty (20) Trading Days with respect to financial statement comments) after the receipt of comments
by or notice from the SEC that an amendment is required in order for a Registration Statement to be declared effective.
(b) Subject
to Section 3(r) of this Agreement, the Company shall prepare and file with the SEC such amendments (including, without limitation,
post-effective amendments) and supplements to each Registration Statement and the prospectus used in connection with each such Registration
Statement, which prospectus is to be filed pursuant to Rule 424 promulgated under the 1933 Act, as may be necessary to keep each such
Registration Statement effective at all times during the Registration Period for such Registration Statement, and, during such period,
comply with the provisions of the 1933 Act with respect to the disposition of all Registrable Securities of the Company required to be
covered by such Registration Statement until such time as all of such Registrable Securities shall have been disposed of in accordance
with the intended methods of disposition by the seller or sellers thereof as set forth in such Registration Statement; provided, however,
by 8:30 a.m. (New York time) on the first (1st) Business Day immediately following each Effective Date, the Company shall file
with the SEC in accordance with Rule 424(b) under the 1933 Act the final prospectus to be used in connection with sales pursuant to the
applicable Registration Statement (whether or not such a prospectus is technically required by such rule). In the case of amendments and
supplements to any Registration Statement which are required to be filed pursuant to this Agreement (including, without limitation, pursuant
to this Section 3(b)) by reason of the Company filing a report on Form 8-K, Form 10-Q or Form 10-K or any analogous report under
the Securities Exchange Act of 1934, as amended (the “1934 Act”), the Company shall, if permitted under the applicable
rules and regulations of the SEC, have incorporated such report by reference into such Registration Statement, if applicable, or shall
file such amendments or supplements with the SEC promptly following the date on which the 1934 Act report is filed which created the requirement
for the Company to amend or supplement such Registration Statement.
(c) The
Company shall (A) permit legal counsel for each Investor to review and comment upon (i) each Registration Statement at least five (5)
Business Days prior to its filing with the SEC and (ii) all amendments and supplements to each Registration Statement (including, without
limitation, the prospectus contained therein) (except for Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports
on Form 8-K, and any similar or successor reports) within a reasonable number of days prior to their filing with the SEC, and (B) not
file any Registration Statement or amendment or supplement thereto in a form to which any legal counsel for any Investor reasonably objects.
The Company shall promptly furnish to legal counsel for each Investor, without charge, (i) copies of any correspondence from the SEC or
the Staff to the Company or its representatives relating to each Registration Statement, provided that such correspondence shall not contain
any material, non-public information regarding the Company or any of its Subsidiaries (as defined in the Securities Purchase Agreement),
(ii) after the same is prepared and filed with the SEC, one (1) copy of each Registration Statement and any amendment(s) and supplement(s)
thereto, including, without limitation, financial statements and schedules, all documents incorporated therein by reference, if requested
by an Investor, and all exhibits and (iii) upon the effectiveness of each Registration Statement, one (1) copy of the prospectus
included in such Registration Statement and all amendments and supplements thereto. The Company shall reasonably cooperate with legal
counsel for each Investor in performing the Company’s obligations pursuant to this Section 3.
(d) If
requested by an Investor, the Company shall promptly furnish to such Investor whose Registrable Securities are included in any Registration
Statement, without charge, (i) after the same is prepared and filed with the SEC, at least one (1) copy of each Registration Statement
and any amendment(s) and supplement(s) thereto, including, without limitation, financial statements and schedules, all documents incorporated
therein by reference, if requested by an Investor, all exhibits and each preliminary prospectus, (ii) upon the effectiveness of each Registration
Statement, ten (10) copies of the prospectus included in such Registration Statement and all amendments and supplements thereto (or
such other number of copies as such Investor may reasonably request from time to time) and (iii) such other documents, including, without
limitation, copies of any preliminary or final prospectus, as such Investor may reasonably request from time to time in order to facilitate
the disposition of the Registrable Securities owned by such Investor.
(e) The
Company shall use its best efforts to (i) register and qualify, unless an exemption from registration and qualification applies, the resale
by Investors of the Registrable Securities covered by a Registration Statement under such other securities or “blue sky” laws
of all applicable jurisdictions in the United States, (ii) prepare and file in those jurisdictions, such amendments (including, without
limitation, post-effective amendments) and supplements to such registrations and qualifications as may be necessary to maintain the effectiveness
thereof during the Registration Period, (iii) take such other actions as may be necessary to maintain such registrations and qualifications
in effect at all times during the Registration Period, and (iv) take all other actions reasonably necessary or advisable to qualify the
Registrable Securities for sale in such jurisdictions; provided, however, the Company shall not be required in connection therewith or
as a condition thereto to (x) qualify to do business in any jurisdiction where it would not otherwise be required to qualify but for this
Section 3(e), (y) subject itself to general taxation in any such jurisdiction, or (z) file a general consent to service of process
in any such jurisdiction. The Company shall promptly notify legal counsel for each Investor and each Investor who holds Registrable Securities
of the receipt by the Company of any notification with respect to the suspension of the registration or qualification of any of the Registrable
Securities for sale under the securities or “blue sky” laws of any jurisdiction in the United States or its receipt of actual
notice of the initiation or threatening of any proceeding for such purpose.
(f) The
Company shall notify legal counsel for each Investor and each Investor in writing of the happening of any event, as promptly as practicable
after becoming aware of such event, as a result of which the prospectus included in a Registration Statement, as then in effect, may include
an untrue statement of a material fact or omission to state a material fact required to be stated therein or necessary to make the statements
therein, in the light of the circumstances under which they were made, not misleading (provided that in no event shall such notice contain
any material, non-public information regarding the Company or any of its Subsidiaries), and, subject to Section 3(r), promptly prepare
a supplement or amendment to such Registration Statement and such prospectus contained therein to correct such untrue statement or omission
and, if requested by such Investor, deliver ten (10) copies of such supplement or amendment to legal counsel for each Investor and each
Investor (or such other number of copies as legal counsel for each Investor or such Investor may reasonably request). The Company shall
also promptly notify legal counsel for each Investor and each Investor in writing (i) when a prospectus or any prospectus supplement or
post-effective amendment has been filed, when a Registration Statement or any post-effective amendment has become effective (notification
of such effectiveness shall be delivered to legal counsel for each Investor and each Investor by e-mail on the same day of such effectiveness
and by overnight mail), and when the Company receives written notice from the SEC that a Registration Statement or any post-effective
amendment will be reviewed by the SEC, (ii) of any request by the SEC for amendments or supplements to a Registration Statement or related
prospectus or related information, (iii) of the Company’s reasonable determination that a post-effective amendment to a Registration
Statement would be appropriate; and (iv) of the receipt of any request by the SEC or any other federal or state governmental authority
for any additional information relating to the Registration Statement or any amendment or supplement thereto or any related prospectus.
The Company shall respond as promptly as practicable to any comments received from the SEC with respect to each Registration Statement
or any amendment thereto (it being understood and agreed that the Company’s response to any such comments shall be delivered to
the SEC no later than fifteen (15) Business Days (or twenty (20) Trading Days with respect to financial statement comments)after
the receipt thereof).
(g) The
Company shall (i) use its best efforts to prevent the issuance of any stop order or other suspension of effectiveness of each Registration
Statement or the use of any prospectus contained therein, or the suspension of the qualification, or the loss of an exemption from qualification,
of any of the Registrable Securities for sale in any jurisdiction and, if such an order or suspension is issued, to obtain the withdrawal
of such order or suspension at the earliest possible moment and (ii) notify legal counsel for each Investor and each Investor who holds
Registrable Securities of the issuance of such order and the resolution thereof or its receipt of actual notice of the initiation or threat
of any proceeding for such purpose.
(h) If
any Investor may be required under applicable securities law to be described in any Registration Statement as an underwriter and such
Investor consents to so being named an underwriter, at the request of any Investor, the Company shall furnish to such Investor, on the
date of the effectiveness of such Registration Statement and thereafter from time to time on such dates as an Investor may reasonably
request (i) a letter, dated such date, from the Company’s independent certified public accountants in form and substance as is customarily
given by independent certified public accountants to underwriters in an underwritten public offering, addressed to the Investors, and
(ii) an opinion, dated as of such date, of counsel representing the Company for purposes of such Registration Statement, in form, scope
and substance as is customarily given in an underwritten public offering, addressed to the Investors.
(i) If
any Investor may be required under applicable securities law to be described in any Registration Statement as an underwriter and such
Investor consents to so being named an underwriter, upon the written request of such Investor, the Company shall make available for inspection
by (i) such Investor, (ii) legal counsel for such Investor and (iii) one (1) firm of accountants or other agents retained by such Investor
(collectively, the “Inspectors”), all pertinent financial and other records, and pertinent corporate documents and
properties of the Company (collectively, the “Records”), as shall be reasonably deemed necessary by each Inspector,
and cause the Company’s officers, directors and employees to supply all information which any Inspector may reasonably request;
provided, however, each Inspector shall agree in writing to hold in strict confidence and not to make any disclosure (except to such Investor)
or use of any Record or other information which the Company’s board of directors determines in good faith to be confidential, and
of which determination the Inspectors are so notified, unless (1) the disclosure of such Records is necessary to avoid or correct a misstatement
or omission in any Registration Statement or is otherwise required under the 1933 Act, (2) the release of such Records is ordered pursuant
to a final, non-appealable subpoena or order from a court or government body of competent jurisdiction, or (3) the information in such
Records has been made generally available to the public other than by disclosure in violation of this Agreement or any other Transaction
Document (as defined in the Securities Purchase Agreement). Such Investor agrees that it shall, upon learning that disclosure of such
Records is sought in or by a court or governmental body of competent jurisdiction or through other means, give prompt notice to the Company
and allow the Company, at its expense, to undertake appropriate action to prevent disclosure of, or to obtain a protective order for,
the Records deemed confidential. Nothing herein (or in any other confidentiality agreement between the Company and such Investor, if any)
shall be deemed to limit any Investor’s ability to sell Registrable Securities in a manner which is otherwise consistent with applicable
laws and regulations.
(j) The
Company shall hold in confidence and not make any disclosure of information concerning an Investor provided to the Company unless (i)
disclosure of such information is necessary to comply with federal or state securities laws, (ii) the disclosure of such information is
necessary to avoid or correct a misstatement or omission in any Registration Statement or is otherwise required to be disclosed in such
Registration Statement pursuant to the 1933 Act, (iii) the release of such information is ordered pursuant to a subpoena or other final,
non-appealable order from a court or governmental body of competent jurisdiction, or (iv) such information has been made generally available
to the public other than by disclosure in violation of this Agreement or any other Transaction Document. The Company agrees that it shall,
upon learning that disclosure of such information concerning an Investor is sought in or by a court or governmental body of competent
jurisdiction or through other means, give prompt written notice to such Investor and allow such Investor, at such Investor’s expense,
to undertake appropriate action to prevent disclosure of, or to obtain a protective order for, such information.
(k) Without
limiting any obligation of the Company under the Securities Purchase Agreement, the Company shall use its best efforts either to (i) cause
all of the Registrable Securities covered by each Registration Statement to be listed on each securities exchange on which securities
of the same class or series issued by the Company are then listed, if any, if the listing of such Registrable Securities is then permitted
under the rules of such exchange, (ii) secure designation and quotation of all of the Registrable Securities covered by each Registration
Statement on an Eligible Market (as defined in the Securities Purchase Agreement), or (iii) if, despite the Company’s best efforts
to satisfy the preceding clauses (i) or (ii) the Company is unsuccessful in satisfying the preceding clauses (i) or (ii), without
limiting the generality of the foregoing, to use its best efforts to arrange for at least two market makers to register with the Financial
Industry Regulatory Authority (“FINRA”) as such with respect to such Registrable Securities. In addition, the Company
shall cooperate with each Investor and any broker or dealer through which any such Investor proposes to sell its Registrable Securities
in effecting a filing with FINRA pursuant to FINRA Rule 5110 as requested by such Investor. The Company shall pay all fees and expenses
in connection with satisfying its obligations under this Section 3(k).
(l) The
Company shall cooperate with the Investors who hold Registrable Securities being offered and, to the extent applicable, facilitate the
timely preparation and delivery of certificates (not bearing any restrictive legend, if the Investor has satisfied the Resale Eligibility
Conditions) representing the Registrable Securities to be offered pursuant to a Registration Statement and enable such certificates to
be in such denominations or amounts (as the case may be) as the Investors may reasonably request from time to time and registered in such
names as the Investors may request.
(m) If
requested by an Investor, the Company shall as soon as practicable after receipt of notice from such Investor and subject to Section 3(r)
hereof, (i) incorporate in a prospectus supplement or post-effective amendment such information as an Investor reasonably requests to
be included therein relating to the sale and distribution of Registrable Securities, including, without limitation, information with respect
to the number of Registrable Securities being offered or sold, the purchase price being paid therefor and any other terms of the offering
of the Registrable Securities to be sold in such offering; (ii) make all required filings of such prospectus supplement or post-effective
amendment after being notified of the matters to be incorporated in such prospectus supplement or post-effective amendment; and (iii)
supplement or make amendments to any Registration Statement or prospectus contained therein if reasonably requested by an Investor holding
any Registrable Securities.
(n) The
Company shall use its best efforts to cause the Registrable Securities covered by a Registration Statement to be registered with or approved
by such other governmental agencies or authorities as may be necessary to consummate the disposition of such Registrable Securities.
(o) The
Company shall make generally available to its security holders as soon as practical, but not later than ninety (90) days after the close
of the period covered thereby, an earnings statement (in form complying with, and in the manner provided by, the provisions of Rule 158
under the 1933 Act) covering a twelve-month period beginning not later than the first day of the Company’s fiscal quarter next following
the applicable Effective Date of each Registration Statement.
(p) The
Company shall otherwise use its best efforts to comply with all applicable rules and regulations of the SEC in connection with any registration
hereunder.
(q) Within
one (1) Business Day after a Registration Statement which covers Registrable Securities is declared effective by the SEC, the Company
shall deliver, and shall cause legal counsel for the Company to deliver, to the transfer agent for such Registrable Securities (with copies
to the Investors whose Registrable Securities are included in such Registration Statement) confirmation that such Registration Statement
has been declared effective by the SEC in the form attached hereto as Exhibit A.
(r) Notwithstanding
anything to the contrary herein (but subject to the last sentence of this Section 3(r)), at any time after the Effective Date of
a particular Registration Statement, the Company may delay the disclosure of material, non-public information concerning the Company or
any of its Subsidiaries the disclosure of which at the time is not, in the good faith opinion of the board of directors of the Company,
in the best interest of the Company and, in the opinion of counsel to the Company, otherwise required (a “Grace Period”),
provided that the Company shall promptly notify the Investors in writing of the (i) existence of material, non-public information giving
rise to a Grace Period (provided that in each such notice the Company shall not disclose the content of such material, non-public information
to any of the Investors) and the date on which such Grace Period will begin and (ii) date on which such Grace Period ends, provided
further that (I) no Grace Period shall exceed ten (10) consecutive days and during any three hundred sixty five (365) day period all such
Grace Periods shall not exceed an aggregate of sixty (60) days (II) the first day of any Grace Period must be at least five (5) Trading
Days after the last day of any prior Grace Period and (III) no Grace Period may exist during the forty (40) Trading Day period immediately
following the Effective Date of such Registration Statement (provided that such forty (40) Trading Day period shall be extended by the
number of Trading Days during such period and any extension thereof contemplated by this proviso during which such Registration Statement
is not effective or the prospectus contained therein is not available for use) (each, an “Allowable Grace Period”).
For purposes of determining the length of a Grace Period above, such Grace Period shall begin on and include the date the Investors receive
the notice referred to in clause (i) above and shall end on and include the later of the date the Investors receive the notice referred
to in clause (ii) above and the date referred to in such notice. The provisions of Section 3(g) hereof shall not be applicable during
the period of any Allowable Grace Period. Upon expiration of each Grace Period, the Company shall again be bound by the first sentence
of Section 3(f) with respect to the information giving rise thereto unless such material, non-public information is no longer applicable.
Notwithstanding anything to the contrary contained in this Section 3(r), the Company shall cause its transfer agent to deliver unlegended
shares of Common Stock to a transferee of an Investor in accordance with the terms of the Securities Purchase Agreement in connection
with any sale of Registrable Securities with respect to which such Investor has entered into a contract for sale, and delivered a copy
of the prospectus included as part of the particular Registration Statement to the extent applicable, prior to such Investor’s receipt
of the notice of a Grace Period and for which the Investor has not yet settled.
(s) The
Company shall take all other reasonable actions necessary to expedite and facilitate disposition by each Investors of its Registrable
Securities pursuant to each Registration Statement.
(t) Neither
the Company nor any Subsidiary or affiliate thereof shall identify any Investor as an underwriter in any public disclosure or filing with
the SEC, the Principal Market or any Eligible Market and any Buyer being deemed an underwriter by the SEC shall not relieve the Company
of any obligations it has under this Agreement or any other Transaction Document (as defined in the Securities Purchase Agreement); provided,
however, that the foregoing shall not prohibit the Company from including the disclosure found in the “Plan of Distribution”
section attached hereto as Exhibit B in the Registration Statement. Notwithstanding the foregoing, if after the required reduction of
the number of shares of Common Stock to be included in a Registration Statement to comply with Rule 415 of the 1933 Act, the SEC still
insists that a Buyer be named as an “underwriter” in such Registration Statement and such Buyer refuses to be named as an
“underwriter” in such Registration Statement, no Registration Delay Payments shall accrue hereunder with respect to such Buyer.
(u) Neither
the Company nor any of its Subsidiaries has entered, as of the date hereof, nor shall the Company or any of its Subsidiaries, on or after
the date of this Agreement, enter into any agreement with respect to its securities, that would have the effect of impairing the rights
granted to the Buyers in this Agreement or otherwise conflicts with the provisions hereof.
4. | Obligations of the Investors. |
(a) At
least five (5) Business Days prior to the first anticipated filing date of each Registration Statement, the Company shall notify each
Investor in writing of the information the Company requires from each such Investor with respect to such Registration Statement. It shall
be a condition precedent to the obligations of the Company to complete the registration pursuant to this Agreement with respect to the
Registrable Securities of a particular Investor that such Investor shall furnish to the Company such information regarding itself, the
Registrable Securities held by it and the intended method of disposition of the Registrable Securities held by it, as shall be reasonably
required to effect and maintain the effectiveness of the registration of such Registrable Securities and shall execute such documents
in connection with such registration as the Company may reasonably request.
(b) Each
Investor, by such Investor’s acceptance of the Registrable Securities, agrees to cooperate with the Company as reasonably requested
by the Company in connection with the preparation and filing of each Registration Statement hereunder, unless such Investor has notified
the Company in writing of such Investor’s election to exclude all of such Investor’s Registrable Securities from such Registration
Statement.
(c) Each
Investor agrees that, upon receipt of any notice from the Company of the happening of any event of the kind described in Section 3(g)
or the first sentence of 3(f), such Investor will immediately discontinue disposition of Registrable Securities pursuant to any Registration
Statement(s) covering such Registrable Securities until such Investor’s receipt of the copies of the supplemented or amended prospectus
contemplated by Section 3(g) or the first sentence of Section 3(f) or receipt of notice that no supplement or amendment is required.
Notwithstanding anything to the contrary in this Section 4(c), the Company shall cause its transfer agent to deliver unlegended shares
of Common Stock to a transferee of an Investor in accordance with the terms of the Securities Purchase Agreement in connection with any
sale of Registrable Securities with respect to which such Investor has entered into a contract for sale prior to the Investor’s
receipt of a notice from the Company of the happening of any event of the kind described in Section 3(g) or the first sentence of
Section 3(f) and for which such Investor has not yet settled.
5. | Expenses of Registration. |
All reasonable expenses, other
than underwriting discounts and commissions, incurred in connection with registrations, filings or qualifications pursuant to Sections 2
and 3, including, without limitation, all registration, listing and qualifications fees, printers and accounting fees, FINRA filing fees
(if any) and fees and disbursements of counsel for the Company shall be paid by the Company.
(a) To
the fullest extent permitted by law, the Company will, and hereby does, indemnify, hold harmless and defend each Investor and each of
its directors, officers, shareholders, members, partners, employees, agents, advisors, representatives (and any other Persons with a functionally
equivalent role of a Person holding such titles notwithstanding the lack of such title or any other title) and each Person, if any, who
controls such Investor within the meaning of the 1933 Act or the 1934 Act and each of the directors, officers, shareholders, members,
partners, employees, agents, advisors, representatives (and any other Persons with a functionally equivalent role of a Person holding
such titles notwithstanding the lack of such title or any other title) of such controlling Persons (each, an “Indemnified Person”),
against any losses, obligations, claims, damages, liabilities, contingencies, judgments, fines, penalties, charges, costs (including,
without limitation, court costs, reasonable attorneys’ fees and costs of defense and investigation), amounts paid in settlement
or expenses, joint or several, (collectively, “Claims”) incurred in investigating, preparing or defending any action,
claim, suit, inquiry, proceeding, investigation or appeal taken from the foregoing by or before any court or governmental, administrative
or other regulatory agency, body or the SEC, whether pending or threatened, whether or not an Indemnified Person is or may be a party
thereto (“Indemnified Damages”), to which any of them may become subject insofar as such Claims (or actions or proceedings,
whether commenced or threatened, in respect thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement
of a material fact in a Registration Statement or any post-effective amendment thereto or in any filing made in connection with the qualification
of the offering under the securities or other “blue sky” laws of any jurisdiction in which Registrable Securities are offered
(“Blue Sky Filing”), or the omission or alleged omission to state a material fact required to be stated therein or
necessary to make the statements therein not misleading, (ii) any untrue statement or alleged untrue statement of a material fact contained
in any preliminary prospectus if used prior to the effective date of such Registration Statement, or contained in the final prospectus
(as amended or supplemented, if the Company files any amendment thereof or supplement thereto with the SEC) or the omission or alleged
omission to state therein any material fact necessary to make the statements made therein, in light of the circumstances under which the
statements therein were made, not misleading or (iii) any violation or alleged violation by the Company of the 1933 Act, the 1934 Act,
any other law, including, without limitation, any state securities law, or any rule or regulation thereunder relating to the offer or
sale of the Registrable Securities pursuant to a Registration Statement or (iv) any violation of this Agreement (the matters in the foregoing
clauses (i) through (iv) being, collectively, “Violations”). Subject to Section 6(c), the Company shall reimburse
the Indemnified Persons, promptly as such expenses are incurred and are due and payable, for any legal fees or other reasonable expenses
incurred by them in connection with investigating or defending any such Claim. Notwithstanding anything to the contrary contained herein,
the indemnification agreement contained in this Section 6(a): (i) shall not apply to a Claim by an Indemnified Person arising out
of or based upon a Violation which occurs in reliance upon and in conformity with information furnished in writing to the Company by such
Indemnified Person for such Indemnified Person expressly for use in connection with the preparation of such Registration Statement or
any such amendment thereof or supplement thereto, if such prospectus was timely made available by the Company pursuant to Section 3(d);
and (ii) shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written consent of
the Company, which consent shall not be unreasonably withheld or delayed. Such indemnity shall remain in full force and effect regardless
of any investigation made by or on behalf of the Indemnified Person and shall survive the transfer of any of the Registrable Securities
by any of the Investors pursuant to Section 9.
(b) In
connection with any Registration Statement in which an Investor is participating, such Investor agrees to severally and not jointly indemnify,
hold harmless and defend, to the same extent and in the same manner as is set forth in Section 6(a), the Company, each of its directors,
each of its officers who signs the Registration Statement and each Person, if any, who controls the Company within the meaning of the
1933 Act or the 1934 Act (each, an “Indemnified Party”), against any Claim or Indemnified Damages to which any of them
may become subject, under the 1933 Act, the 1934 Act or otherwise, insofar as such Claim or Indemnified Damages arise out of or are based
upon any Violation, in each case, to the extent, and only to the extent, that such Violation occurs in reliance upon and in conformity
with written information furnished to the Company by such Investor expressly for use in connection with such Registration Statement; and,
subject to Section 6(c) and the below provisos in this Section 6(b), such Investor will reimburse an Indemnified Party any legal
or other expenses reasonably incurred by such Indemnified Party in connection with investigating or defending any such Claim; provided,
however, the indemnity agreement contained in this Section 6(b) and the agreement with respect to contribution contained in Section 7
shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written consent of such Investor,
which consent shall not be unreasonably withheld or delayed, provided further that such Investor shall be liable under this Section 6(b)
for only that amount of a Claim or Indemnified Damages as does not exceed the net proceeds to such Investor as a result of the applicable
sale of Registrable Securities pursuant to such Registration Statement. Such indemnity shall remain in full force and effect regardless
of any investigation made by or on behalf of such Indemnified Party and shall survive the transfer of any of the Registrable Securities
by any of the Investors pursuant to Section 9.
(c) Promptly
after receipt by an Indemnified Person or Indemnified Party (as the case may be) under this Section 6 of notice of the commencement
of any action or proceeding (including, without limitation, any governmental action or proceeding) involving a Claim, such Indemnified
Person or Indemnified Party (as the case may be) shall, if a Claim in respect thereof is to be made against any indemnifying party under
this Section 6, deliver to the indemnifying party a written notice of the commencement thereof, and the indemnifying party shall
have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly
noticed, to assume control of the defense thereof with counsel mutually satisfactory to the indemnifying party and the Indemnified Person
or the Indemnified Party (as the case may be); provided, however, an Indemnified Person or Indemnified Party (as the case may be) shall
have the right to retain its own counsel with the fees and expenses of such counsel to be paid by the indemnifying party if: (i) the indemnifying
party has agreed in writing to pay such fees and expenses; (ii) the indemnifying party shall have failed promptly to assume the defense
of such Claim and to employ counsel reasonably satisfactory to such Indemnified Person or Indemnified Party (as the case may be) in any
such Claim; or (iii) the named parties to any such Claim (including, without limitation, any impleaded parties) include both such Indemnified
Person or Indemnified Party (as the case may be) and the indemnifying party, and such Indemnified Person or such Indemnified Party (as
the case may be) shall have been advised by counsel that a conflict of interest is likely to exist if the same counsel were to represent
such Indemnified Person or such Indemnified Party and the indemnifying party (in which case, if such Indemnified Person or such Indemnified
Party (as the case may be) notifies the indemnifying party in writing that it elects to employ separate counsel at the expense of the
indemnifying party), then the indemnifying party shall not have the right to assume the defense thereof and such counsel shall be at the
expense of the indemnifying party, provided further that in the case of clause (iii) above the indemnifying party shall not be responsible
for the reasonable fees and expenses of more than one (1) separate legal counsel for such Indemnified Person or Indemnified Party (as
the case may be). The Indemnified Party or Indemnified Person (as the case may be) shall reasonably cooperate with the indemnifying party
in connection with any negotiation or defense of any such action or Claim by the indemnifying party and shall furnish to the indemnifying
party all information reasonably available to the Indemnified Party or Indemnified Person (as the case may be) which relates to such action
or Claim. The indemnifying party shall keep the Indemnified Party or Indemnified Person (as the case may be) reasonably apprised at all
times as to the status of the defense or any settlement negotiations with respect thereto. No indemnifying party shall be liable for any
settlement of any action, claim or proceeding effected without its prior written consent; provided, however, the indemnifying party shall
not unreasonably withhold, delay or condition its consent. No indemnifying party shall, without the prior written consent of the Indemnified
Party or Indemnified Person (as the case may be), consent to entry of any judgment or enter into any settlement or other compromise which
does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party or Indemnified Person
(as the case may be) of a release from all liability in respect to such Claim or litigation, and such settlement shall not include any
admission as to fault on the part of the Indemnified Party. Following indemnification as provided for hereunder, the indemnifying party
shall be subrogated to all rights of the Indemnified Party or Indemnified Person (as the case may be) with respect to all third parties,
firms or corporations relating to the matter for which indemnification has been made. The failure to deliver written notice to the indemnifying
party within a reasonable time of the commencement of any such action shall not relieve such indemnifying party of any liability to the
Indemnified Person or Indemnified Party (as the case may be) under this Section 6, except to the extent that the indemnifying party
is materially and adversely prejudiced in its ability to defend such action.
(d) The
indemnification required by this Section 6 shall be made by periodic payments of the amount thereof during the course of the investigation
or defense, as and when bills are received or Indemnified Damages are incurred.
(e) The
indemnity and contribution agreements contained herein shall be in addition to (i) any cause of action or similar right of the Indemnified
Party or Indemnified Person against the indemnifying party or others, and (ii) any liabilities the indemnifying party may be subject to
pursuant to the law.
To the extent any indemnification
by an indemnifying party is prohibited or limited by law, the indemnifying party agrees to make the maximum contribution with respect
to any amounts for which it would otherwise be liable under Section 6 to the fullest extent permitted by law; provided, however:
(i) no contribution shall be made under circumstances where the maker would not have been liable for indemnification under the fault standards
set forth in Section 6 of this Agreement, (ii) no Person involved in the sale of Registrable Securities which Person is guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the 1933 Act) in connection with such sale shall be entitled to contribution
from any Person involved in such sale of Registrable Securities who was not guilty of fraudulent misrepresentation; and (iii) contribution
by any seller of Registrable Securities shall be limited in amount to the amount of net proceeds received by such seller from the applicable
sale of such Registrable Securities pursuant to such Registration Statement. Notwithstanding the provisions of this Section 7, no
Investor shall be required to contribute, in the aggregate, any amount in excess of the amount by which the net proceeds actually received
by such Investor from the applicable sale of the Registrable Securities subject to the Claim exceeds the amount of any damages that such
Investor has otherwise been required to pay, or would otherwise be required to pay under Section 6(b), by reason of such untrue or
alleged untrue statement or omission or alleged omission.
8. | Reports Under the 1934 Act. |
With a view to making available
to the Investors the benefits of Rule 144, the Company agrees to:
(a) make
and keep public information available, as those terms are understood and defined in Rule 144;
(b) file
with the SEC in a timely manner all reports and other documents required of the Company under the 1933 Act and the 1934 Act so long as
the Company remains subject to such requirements (it being understood and agreed that nothing herein shall limit any obligations of the
Company under the Securities Purchase Agreement) and the filing of such reports and other documents is required for the applicable provisions
of Rule 144; and
(c) furnish
to each Investor so long as such Investor owns Registrable Securities, promptly upon request, (i) a written statement by the Company,
if true, that it has complied with the reporting, submission and posting requirements of Rule 144, the 1933 Act and the 1934 Act, (ii)
a copy of the most recent annual or quarterly report of the Company and such other reports and documents so filed by the Company with
the SEC if such reports are not publicly available via EDGAR, and (iii) such other information as may be reasonably requested to
permit the Investors to sell such securities pursuant to Rule 144 without registration.
9. | Assignment of Registration Rights. |
All or any portion of the
rights under this Agreement shall be automatically assignable by each Investor to any transferee or assignee (as the case may be) of all
or any portion of such Investor’s Registrable Securities or Series B Preferred Shares if: (i) such Investor agrees in writing with
such transferee or assignee (as the case may be) to assign all or any portion of such rights, and a copy of such agreement is furnished
to the Company within a reasonable time after such transfer or assignment (as the case may be); (ii) the Company is, within a reasonable
time after such transfer or assignment (as the case may be), furnished with written notice of (a) the name and address of such transferee
or assignee (as the case may be), and (b) the securities with respect to which such registration rights are being transferred or assigned
(as the case may be); (iii) immediately following such transfer or assignment (as the case may be) the further disposition of such
securities by such transferee or assignee (as the case may be) is restricted under the 1933 Act or applicable state securities laws if
so required; (iv) at or before the time the Company receives the written notice contemplated by clause (ii) of this sentence such transferee
or assignee (as the case may be) agrees in writing with the Company to be bound by all of the provisions contained herein; (v) such transfer
or assignment (as the case may be) shall have been made in accordance with the applicable requirements of the Securities Purchase Agreement
and the Series B Preferred Shares (as the case may be); and (vi) such transfer or assignment (as the case may be) shall have been conducted
in accordance with all applicable federal and state securities laws.
10. | Amendment of Registration Rights. |
Provisions of this Agreement
may be amended and the observance thereof may be waived (either generally or in a particular instance and either retroactively or prospectively),
only with the written consent of the Company and the Required Holders; provided that any such amendment or waiver that complies with the
foregoing, but that disproportionately, materially and adversely affects the rights and obligations of any Investor relative to the comparable
rights and obligations of the other Investors shall require the prior written consent of such adversely affected Investor. Any amendment
or waiver effected in accordance with this Section 10 shall be binding upon each Investor and the Company, provided that no such amendment
shall be effective to the extent that it (1) applies to less than all of the holders of Registrable Securities or (2) imposes any obligation
or liability on any Investor without such Investor’s prior written consent (which may be granted or withheld in such Investor’s
sole discretion). No waiver shall be effective unless it is in writing and signed by an authorized representative of the waiving party.
No consideration shall be offered or paid to any Person to amend or consent to a waiver or modification of any provision of this Agreement
unless the same consideration (other than the reimbursement of legal fees) also is offered to all of the parties to this Agreement.
(a) Solely
for purposes of this Agreement, a Person is deemed to be a holder of Registrable Securities whenever such Person owns, or is deemed to
own, of record such Registrable Securities. If the Company receives conflicting instructions, notices or elections from two or more Persons
with respect to the same Registrable Securities, the Company shall act upon the basis of instructions, notice or election received from
such record owner of such Registrable Securities.
(b) Any
notices, consents, waivers or other communications required or permitted to be given under the terms of this Agreement must be in writing
and will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt, when sent by electronic mail
(provided that such sent email is kept on file (whether electronically or otherwise) by the sending party and the sending party does not
receive an automatically generated message from the recipient’s email server that such e-mail could not be delivered to such recipient);
or (iii) one (1) Business Day after deposit with an overnight courier service with next day delivery specified, in each case, properly
addressed to the party to receive the same. The mailing addresses and e-mail addresses for such communications shall be:
If to the Company:
CERo Therapeutics Holdings, Inc.
201 Haskins Way, Suite 230
South San Francisco, CA 94080
Telephone:
Attention: Chief Executive Officer
Email:
With a copy (for informational purposes only) to:
Goodwin Procter LLP
The New York Times Building
620 Eighth Avenue
New York, NY 10018
Telephone:
Attention: Jeffrey A. Letalien, Esq.
Email:
If to the Transfer Agent:
Continental Stock Transfer & Trust Company
1 State Street 30th Floor
New York, NY 10004-1561
Telephone:
Attention: Luis Ortiz
Email:
If to a Buyer, to its mailing address and/or email
address set forth on the Schedule of Buyers attached to the Securities Purchase Agreement, with copies to such Buyer’s representatives
as set forth on the Schedule of Buyers, or to such other mailing address and/or email address and/or to the attention of such other Person
as the recipient party has specified by written notice given to each other party five (5) days prior to the effectiveness of such change.
Written confirmation of receipt (A) given by the recipient of such notice, consent, waiver or other communication, (B) mechanically
or electronically generated by the sender’s e-mail containing the time, date and recipient’s e-mail or (C) provided by a courier
or overnight courier service shall be rebuttable evidence of personal service, receipt by e-mail or receipt from a nationally recognized
overnight delivery service in accordance with clause (i), (ii) or (iii) above, respectively.
(c) Failure
of any party to exercise any right or remedy under this Agreement or otherwise, or delay by a party in exercising such right or remedy,
shall not operate as a waiver thereof. The Company and each Investor acknowledge and agree that irreparable damage would occur in the
event that any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached.
It is accordingly agreed that each party hereto shall be entitled to an injunction or injunctions to prevent or cure breaches of the provisions
of this Agreement by any other party hereto and to enforce specifically the terms and provisions hereof (without the necessity of showing
economic loss and without any bond or other security being required), this being in addition to any other remedy to which any party may
be entitled by law or equity.
(d) All
questions concerning the construction, validity, enforcement and interpretation of this Agreement shall be governed by the internal laws
of the State of Delaware, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of Delaware
or any other jurisdictions) that would cause the application of the laws of any jurisdictions other than the State of Delaware. Each party
hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in Wilmington, Delaware, for the adjudication
of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably
waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of
any such court, that such suit, action or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding
is improper. Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action
or proceeding by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such
service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit
in any way any right to serve process in any manner permitted by law. EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE TO, AND
AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT
OR ANY TRANSACTION CONTEMPLATED HEREBY.
(e) If
any provision of this Agreement is prohibited by law or otherwise determined to be invalid or unenforceable by a court of competent jurisdiction,
the provision that would otherwise be prohibited, invalid or unenforceable shall be deemed amended to apply to the broadest extent that
it would be valid and enforceable, and the invalidity or unenforceability of such provision shall not affect the validity of the remaining
provisions of this Agreement so long as this Agreement as so modified continues to express, without material change, the original intentions
of the parties as to the subject matter hereof and the prohibited nature, invalidity or unenforceability of the provision(s) in question
does not substantially impair the respective expectations or reciprocal obligations of the parties or the practical realization of the
benefits that would otherwise be conferred upon the parties. The parties will endeavor in good faith negotiations to replace the prohibited,
invalid or unenforceable provision(s) with a valid provision(s), the effect of which comes as close as possible to that of the prohibited,
invalid or unenforceable provision(s).
(f) This
Agreement, the other Transaction Documents, the schedules and exhibits attached hereto and thereto and the instruments referenced herein
and therein constitute the entire agreement among the parties hereto and thereto solely with respect to the subject matter hereof and
thereof. There are no restrictions, promises, warranties or undertakings, other than those set forth or referred to herein and therein.
This Agreement, the other Transaction Documents, the schedules and exhibits attached hereto and thereto and the instruments referenced
herein and therein supersede all prior agreements and understandings among the parties hereto solely with respect to the subject matter
hereof and thereof; provided, however, nothing contained in this Agreement or any other Transaction Document shall (or shall be deemed
to) (i) have any effect on any agreements any Investor has entered into with the Company or any of its Subsidiaries prior to the date
hereof with respect to any prior investment made by such Investor in the Company, (ii) waive, alter, modify or amend in any respect any
obligations of the Company or any of its Subsidiaries or any rights of or benefits to any Investor or any other Person in any agreement
entered into prior to the date hereof between or among the Company and/or any of its Subsidiaries and any Investor and all such agreements
shall continue in full force and effect or (iii) limit any obligations of any party under any of the other Transaction Documents.
(g) Subject
to compliance with Section 9 (if applicable), this Agreement shall inure to the benefit of and be binding upon the permitted successors
and assigns of each of the parties hereto. This Agreement is not for the benefit of, nor may any provision hereof be enforced by, any
Person, other than the parties hereto, their respective permitted successors and assigns and the Persons referred to in Sections 6
and 7 hereof.
(h) The
headings in this Agreement are for convenience of reference only and shall not limit or otherwise affect the meaning hereof. Unless the
context clearly indicates otherwise, each pronoun herein shall be deemed to include the masculine, feminine, neuter, singular and plural
forms thereof. The terms “including,” “includes,” “include” and words of like import shall be construed
broadly as if followed by the words “without limitation.” The terms “herein,” “hereunder,” “hereof”
and words of like import refer to this entire Agreement instead of just the provision in which they are found.
(i) This
Agreement may be executed in two or more identical counterparts, each of which shall be deemed an original, but all of which shall be
considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the
other party. In the event that any signature is delivered by facsimile transmission or by an email which contains a portable document
format (.pdf) file of an executed signature page, such signature page shall create a valid and binding obligation of the party executing
(or on whose behalf such signature is executed) with the same force and effect as if such signature page were an original thereof.
(j) Each
party shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver all such
other agreements, certificates, instruments and documents as any other party may reasonably request in order to carry out the intent and
accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby.
(k) The
language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent and no rules of
strict construction will be applied against any party. Notwithstanding anything to the contrary set forth in Section 10, terms used in
this Agreement but defined in the other Transaction Documents shall have the meanings ascribed to such terms on the Closing Date in such
other Transaction Documents unless otherwise consented to in writing by each Investor.
(l) All
consents and other determinations required to be made by the Investors pursuant to this Agreement shall be made, unless otherwise specified
in this Agreement, by the Required Holders, determined as if all of the outstanding Series B Preferred Shares then held by the Investors
have been converted for Registrable Securities without regard to any limitations on redemption, amortization and/or conversion of the
Series B Preferred Shares and the outstanding Common Warrants then held by Investors have been exercised for Registrable Securities without
regard to any limitations on exercise of the Common Warrants.
(m) This
Agreement is intended for the benefit of the parties hereto and their respective permitted successors and assigns, and is not for the
benefit of, nor may any provision hereof be enforced by, any other Person.
(n) The
obligations of each Investor under this Agreement and the other Transaction Documents are several and not joint with the obligations of
any other Investor, and no Investor shall be responsible in any way for the performance of the obligations of any other Investor under
this Agreement or any other Transaction Document. Nothing contained herein or in any other Transaction Document, and no action taken by
any Investor pursuant hereto or thereto, shall be deemed to constitute the Investors as, and the Company acknowledges that the Investors
do not so constitute, a partnership, an association, a joint venture or any other kind of group or entity, or create a presumption that
the Investors are in any way acting in concert or as a group or entity with respect to such obligations or the transactions contemplated
by the Transaction Documents or any matters, and the Company acknowledges that the Investors are not acting in concert or as a group,
and the Company shall not assert any such claim, with respect to such obligations or the transactions contemplated by this Agreement or
any of the other the Transaction Documents. Each Investor shall be entitled to independently protect and enforce its rights, including,
without limitation, the rights arising out of this Agreement or out of any other Transaction Documents, and it shall not be necessary
for any other Investor to be joined as an additional party in any proceeding for such purpose. The use of a single agreement with respect
to the obligations of the Company contained herein was solely in the control of the Company, not the action or decision of any Investor,
and was done solely for the convenience of the Company and not because it was required or requested to do so by any Investor. It is expressly
understood and agreed that each provision contained in this Agreement and in each other Transaction Document is between the Company and
an Investor, solely, and not between the Company and the Investors collectively and not between and among Investors.
[signature page follows]
IN WITNESS WHEREOF, each Buyer and the Company
have caused their respective signature page to this Registration Rights Agreement to be duly executed as of the date first written above.
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COMPANY: |
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CERO THERAPEUTICS HOLDINGS, INC. |
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By: |
/s/ Charles Carter |
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Name: |
Charles Carter |
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Title: |
Chief Financial Officer |
IN WITNESS WHEREOF, each Buyer and the Company
have caused their respective signature page to this Registration Rights Agreement to be duly executed as of the date first written above.
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BUYERS: |
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[BUYERS] |
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By: |
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Name: |
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Title: |
Exhibit 10.15
CERO
THERAPEUTIC HOLDINGS, INC.
EXECUTIVE
EMPLOYMENT AGREEMENT
for
EMPLOYEE
This
Executive Employment Agreement (the “Agreement”), made between CERO Therapeutic Holdings, Inc. (the
“Company”) and Brian G. Atwood (the “Executive”) (collectively, the
“Parties”), is effective as of March 28, 2024 (“Effective Date”).
Whereas,
the Company desires for Executive to provide services to the Company, and wishes to provide Executive with certain compensation and benefits
in return for such services, as set forth in this Agreement; and
Whereas,
Executive wishes to be employed by the Company and to provide personal services to the Company in return for certain compensation and
benefits, as set forth in this Agreement;
Now,
Therefore, in consideration of the mutual promises
and covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged,
the Parties hereto agree as follows:
1. Employment
by the Company.
1.1 Position.
Executive shall serve as the Company’s Chairman, President and CEO. During the term of Executive’s employment with the
Company, Executive will devote Executive’s best efforts and substantially all of Executive’s business time and attention
to the business of the Company, except for approved vacation periods and reasonable periods of illness or other incapacities permitted
by the Company’s general employment policies.
1.2 Duties
and Location. Executive shall perform such duties as are required by the Company’s Board of Directors (the “Board”),
to whom Executive will report. Executive’s primary office location shall be the Company’s California office. The Company
reserves the right to reasonably require Executive to perform Executive’s duties at places other than Executive’s primary
office location from time to time, and to require reasonable business travel. The Company may modify Executive’s job title and
duties as it deems necessary and appropriate in light of the Company’s needs and interests from time to time.
1.3 Policies
and Procedures. The employment relationship between the Parties shall be governed by the general employment policies and practices
of the Company, as adopted or modified from time to time in the Company’s discretion, except that when the terms of this Agreement
differ from or are in conflict with the Company’s general employment policies or practices, this Agreement shall control.
2. Compensation.
2.1 Salary.
For services to be rendered hereunder, Executive shall receive a base salary at the rate of three hundred sixty thousand dollars
($360,000) per year (the “Base Salary”), subject to standard payroll deductions and withholdings and payable in accordance
with the Company’s regular payroll schedule. As an exempt salaried employee, Executive will be required to work the Company’s
normal business hours, and such additional time as appropriate for Executive’s work assignments and position, and Executive will
not be entitled to overtime compensation.
2.2 Bonus.
Executive will be eligible for an annual discretionary bonus of up to fifty percent (50%) of Executive’s Base Salary (the “Annual
Bonus”). Whether Executive receives an Annual Bonus for any given year, and the amount of any such Annual Bonus, will be determined
by the Board in its sole discretion based upon the Company’s and Executive’s achievement of objectives and milestones to
be determined on an annual basis by the Board. Executive must remain an active employee through the end of any given calendar year in
order to earn an Annual Bonus for that year and any such bonus will be paid prior to March 15 of the calendar year after the applicable
bonus year. Executive will not be eligible for, and will not earn, any Annual Bonus (including a prorated bonus) if Executive’s
employment terminates for any reason before the end of the calendar year.
3. Standard
Company Benefits. Executive shall be entitled to participate in all employee benefit programs for which
Executive is eligible under the terms and conditions of the benefit plans and applicable policies that may be in effect from time to
time and provided by the Company to its employees, including but not limited to: medical, dental and vision insurance; life insurance;
short-term and long-term disability insurance; 401(k) plan; and the ability to take time off with pay within Executive’s discretion
pursuant to the Company’s nonaccrual paid time off policy for exempt employees. The Company reserves the right to cancel or change
the benefit plans or programs it offers to its employees at any time.
4. Expenses.
The Company will reimburse Executive for reasonable travel, entertainment or other expenses incurred
by Executive in furtherance or in connection with the performance of Executive’s duties hereunder, in accordance with the Company’s
expense reimbursement policy as in effect from time to time.
5. Equity.
Subject to approval by the Board (which will be sought promptly following Executive’s joining
the Company as its CEO), Executive shall be granted an option to purchase 1,317,596 shares (representing 5.0% of the Company’s
Common Stock, calculated on a fully diluted, as-converted basis, as of immediately after the grant), with an exercise price equal to
the fair market value as determined by the Board on the date of grant (the “Option”).
The Option will be subject to (1) acceleration of 25% of the Option immediately, and (2) for the remainder of the Option a four (4)-year
vesting period subject to Executive’s continued employment with the Company, the Option vesting in forty-eight (48) equal monthly
installments thereafter, in each case subject to Executive’s continued employment through the applicable vesting dates, except
that (i) 10 % of the Option shall accelerate upon Acceptance of the first IND by the Food and Drug Administration by September 30 2024
and (ii) 10 % of the Option shall accelerate upon the successful completion of safe dosing of 10 patients in the Company’s first
Phase I study by 12 months following Acceptance of the first IND by the Food and Drug Administration. The Option shall be governed in
all respects by the terms of the governing plan documents and option or stock purchase agreement between Executive and the Company.
6. Termination
of Employment; Severance.
6.1 At-Will
Employment. Executive’s employment relationship is at-will. The Company may terminate the employment relationship at any time,
with or without Cause (as defined below) or advance notice. Executive may terminate this Agreement for any reason upon thirty (30) days
prior written notice to the Company.
6.2 Termination
Without Cause; Resignation for Good Reason.
(i) The
Company may terminate Executive’s employment with the Company at any time without Cause. Further, Executive may resign his employment
at any time for Good Reason (as defined below).
(ii) In
the event Executive’s employment with the Company is terminated by the Company without Cause (other than as a result of Executive’s
death or disability), or Executive resigns his employment for Good Reason, in either case prior to the thirty (30)-day period prior to
the closing of a Change of Control (as defined below) or more than twelve (12) months following the closing of a Change of Control, then
provided such termination constitutes a “separation from service” (as defined under Treasury Regulation Section 1.409A-1(h),
without regard to any alternative definition thereunder, a “Separation from Service”), then subject to Paragraph 7
(“Conditions to Receipt of Severance, Special Cash Payments and Accelerated Vesting”) and Executive’s continued compliance
with the terms of this Agreement (including the Confidentiality Agreement), the Company shall provide Executive with the following severance
benefits:
(a) The
Company shall pay Executive, as severance, the equivalent of three (3) months of Executive’s Base Salary in effect as of the date
of Executive’s employment termination, subject to standard payroll deductions and withholdings (the “Severance”).
The Severance will be paid in a lump sum on the sixtieth (60th) day following Executive’s Separation from Service, provided
the Separation Agreement (as discussed in Paragraph 7) has become effective.
(iii) If
the Company terminates Executive’s employment with the Company without Cause (other than as a result of Executive’s death
or disability), or Executive resigns his employment for Good Reason, in either case within thirty (30) days prior to or twelve (12) months
following the closing of a Change of Control, then in addition to the Severance, the Company shall accelerate the vesting of all outstanding
unvested equity awards granted to Executive, including but not limited to the Option, such that one hundred percent (100%) of such equity
awards shall be deemed immediately vested and exercisable (if applicable) as of Executive’s last day of employment (the “Change
of Control Accelerated Vesting”).
(iv) If
Executive’s employment with the Company terminates as a result of Executive’s death or disability, the Company shall accelerate
the vesting of fifty percent (50%) of the outstanding then-unvested equity awards granted to Executive, including but not limited to
the Option, as of Executive’s last day of employment (the “Unforeseen Events Accelerated Vesting,” and either
the Change of Control Accelerated Vesting or the Unforeseen Events Acceleration, the “Accelerated Vesting”), it being
acknowledged and agreed that, other than the Unforeseen Events Accelerated Vesting, Executive shall not be entitled to any Severance,
COBRA Premiums (or Special Cash Payments) if Executive’s employment with the Company terminates as a result of Executive’s
death or disability.
6.3 Termination
for Cause; Resignation Without Good Reason; Death or Disability.
(i) The
Company may terminate Executive’s employment with the Company at any time for Cause. Further, Executive may resign his employment
at any time without Good Reason. Executive’s employment with the Company may also be terminated due to Executive’s death
or disability.
(ii) If
Executive resigns his employment without Good Reason, or the Company terminates Executive’s employment for Cause, or if Executive’s
employment terminates as a result of Executive’s death or disability, then except as set forth as to Unforeseen Events Acceleration
above, (a) Executive will no longer vest in the Stock Awards or any other equity awards, (b) all payments of compensation by the Company
to Executive hereunder will terminate immediately (except as to amounts already earned), and (c) Executive will not be entitled to any
severance benefits, including (without limitation) the Severance, Special Cash Payments or Accelerated Vesting. In addition, Executive
shall resign from all positions and terminate any relationships as an employee, advisor, officer or director with the Company and any
of its affiliates, each effective on the date of employment termination.
7. Conditions
to Receipt of Severance, Special Cash Payments and Accelerated Vesting. The receipt of the Severance,
Special Cash Payments and Accelerated Vesting will be subject to Executive signing and not revoking a separation agreement and release
of claims in a form reasonably satisfactory to the Company within sixty (60) days following the date of Executive’s Separation
from Service (the “Separation Agreement”). No Severance, Special Cash Payments or
Accelerated Vesting will be paid or provided until the Separation Agreement becomes effective. Executive shall also resign from all positions
and terminate any relationships as an employee, advisor, officer or director with the Company and any of its affiliates, each effective
on the date of employment termination.
8. Section
409A. It is intended that all of the severance benefits and other payments payable under this Agreement
satisfy, to the greatest extent possible, the exemptions from the application of Section 409A of the Internal Revenue Code of 1986, as
amended (the “Code”) (Section 409A, together with any state law of similar effect,
“Section 409A”) provided under Treasury Regulations 1.409A-1(b)(4), 1.409A-1(b)(5)
and 1.409A-1(b)(9), and this Agreement will be construed to the greatest extent possible as consistent with those provisions, and to
the extent not so exempt, this Agreement (and any definitions hereunder) will be construed in a manner that complies with Section 409A.
For purposes of Section 409A (including, without limitation, for purposes of Treasury Regulation Section 1.409A-2(b)(2)(iii)), Executive’s
right to receive any installment payments under this Agreement (whether severance payments, reimbursements or otherwise) shall be treated
as a right to receive a series of separate payments and, accordingly, each installment payment hereunder shall at all times be considered
a separate and distinct payment. Notwithstanding any provision to the contrary in this Agreement, if Executive is deemed by the Company
at the time of Executive’s Separation from Service to be a “specified employee” for purposes of Section 409A(a)(2)(B)(i),
and if any of the payments upon Separation from Service set forth herein and/or under any other agreement with the Company are deemed
to be “deferred compensation”, then to the extent delayed commencement of any portion of such payments is required in order
to avoid a prohibited distribution under Section 409A(a)(2)(B)(i) and the related adverse taxation under Section 409A, such payments
shall not be provided to Executive prior to the earliest of (i) the expiration of the six (6)-month period measured from the date of
Executive’s Separation from Service with the Company, (ii) the date of Executive’s death or (iii) such earlier date as permitted
under Section 409A without the imposition of adverse taxation. Upon the first business day following the expiration of such applicable
Section 409A(a)(2)(B)(i) period, all payments deferred pursuant to this Paragraph shall be paid in a lump sum to Executive, and any remaining
payments due shall be paid as otherwise provided herein or in the applicable agreement. No interest shall be due on any amounts so deferred.
If any of the severance benefits set forth herein are not covered by one or more exemptions from the application of Section 409A and
the Separation Agreement could become effective in the calendar year following the calendar year in which Executive has a Separation
from Service, the Separation Agreement will not be deemed effective any earlier than the Effective Date set forth in such Separation
Agreement. The severance benefits set forth herein are intended to qualify for an exemption from application of Section 409A or comply
with its requirements to the extent necessary to avoid adverse personal tax consequences under Section 409A, and any ambiguities herein
shall be interpreted accordingly. Notwithstanding anything to the contrary herein, to the extent required to comply with Section 409A,
a termination of employment shall not be deemed to have occurred for purposes of any provision of this Agreement providing for the payment
of amounts or benefits upon or following a termination of employment unless such termination is also a “separation from service”
within the meaning of Section 409A. With respect to reimbursements or in-kind benefits provided to Executive hereunder (or otherwise)
that are not exempt from Section 409A, the following rules shall apply: (i) the amount of expenses eligible for reimbursement, or in-kind
benefits provided, during any one of Executive’s taxable years shall not affect the expenses eligible for reimbursement, or in-kind
benefit to be provided in any other taxable year, (ii) in the case of any reimbursements of eligible expenses, reimbursement shall be
made on or before the last day of Executive’s taxable year following the taxable year in which the expense was incurred, (iii)
the right to reimbursement or in-kind benefits shall not be subject to liquidation or exchange for another benefit.
9.
Section 280G; Parachute Payments.
9.1 If
any payment or benefit Executive will or may receive from the Company or otherwise (a “280G Payment”) would (i) constitute
a “parachute payment” within the meaning of Section 280G of the Code, and (ii) but for this sentence, be subject to
the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then any such 280G Payment provided pursuant
to this Agreement (a “Payment”) shall be equal to the Reduced Amount. The “Reduced Amount” shall be either
(x) the largest portion of the Payment that would result in no portion of the Payment (after reduction) being subject to the Excise Tax
or (y) the largest portion, up to and including the total, of the Payment, whichever amount (i.e., the amount determined by clause (x)
or by clause (y)), after taking into account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax
(all computed at the highest applicable marginal rate), results in Executive’s receipt, on an after-tax basis, of the greater economic
benefit notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in a Payment is required
pursuant to the preceding sentence and the Reduced Amount is determined pursuant to clause (x) of the preceding sentence, the reduction
shall occur in the manner (the “Reduction Method”) that results in the greatest economic benefit for Executive. If
more than one method of reduction will result in the same economic benefit, the items so reduced will be reduced pro rata (the “Pro
Rata Reduction Method”).
9.2 Notwithstanding
any provision of Section 9.1 above to the contrary, if the Reduction Method or the Pro Rata Reduction Method would result in any portion
of the Payment being subject to taxes pursuant to Section 409A that would not otherwise be subject to taxes pursuant to Section 409A,
then the Reduction Method and/or the Pro Rata Reduction Method, as the case may be, shall be modified so as to avoid the imposition of
taxes pursuant to Section 409A as follows: (A) as a first priority, the modification shall preserve to the greatest extent possible,
the greatest economic benefit for Executive as determined on an after-tax basis; (B) as a second priority, Payments that are contingent
on future events (e.g., being terminated without Cause), shall be reduced (or eliminated) before Payments that are not contingent on
future events; and (C) as a third priority, Payments that are “deferred compensation” within the meaning of Section 409A
shall be reduced (or eliminated) before Payments that are not deferred compensation within the meaning of Section 409A.
9.3 Unless
Executive and the Company agree on an alternative accounting firm or law firm, the accounting firm engaged by the Company for general
tax compliance purposes as of the day prior to the effective date of the Change in Control transaction shall perform the foregoing calculations.
If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group effecting the
change in control transaction, the Company shall appoint a nationally recognized accounting or law firm to make the determinations required
by this Section 9 (“Section 280G; Parachute Payments”). The Company shall bear all expenses with respect to the determinations
by such accounting or law firm required to be made hereunder. The Company shall use commercially reasonable efforts to cause the accounting
or law firm engaged to make the determinations hereunder to provide its calculations, together with detailed supporting documentation,
to Executive and the Company within fifteen (15) calendar days after the date on which Executive’s right to a 280G Payment becomes
reasonably likely to occur (if requested at that time by Executive or the Company) or such other time as requested by Executive or the
Company.
9.4 If
Executive receives a Payment for which the Reduced Amount was determined pursuant to clause (x) of Section 9.1 and the Internal
Revenue Service determines thereafter that some portion of the Payment is subject to the Excise Tax, Executive agrees to promptly return
to the Company a sufficient amount of the Payment (after reduction pursuant to clause (x) of Section 9.1) so that no portion of the remaining
Payment is subject to the Excise Tax. For the avoidance of doubt, if the Reduced Amount was determined pursuant to clause (y) of Section
9.1, Executive shall have no obligation to return any portion of the Payment pursuant to the preceding sentence.
10. Definitions.
(i) Cause.
For purposes of this Agreement, “Cause” for termination will mean: (a) commission of any felony or crime involving
dishonesty; (b) participation in any fraud against the Company; (c) material breach of Executive’s duties to the Company; (d) intentional
damage to any property of the Company; (e) misconduct, or other violation of Company policy that causes harm; (f) breach of any written
agreement with the Company; and
(g) conduct by Executive which in the good faith and reasonable determination of the Board demonstrates gross unfitness to serve.
(ii) Change
of Control. For purposes of this Agreement, “Change of Control” shall mean a Change of Control as such term is
defined in the Company’s Amended and Restated Certificate of Incorporation including any Certificate of Designation as in effect
on the applicable date of the Change of Control.
(iii) Good
Reason. For purposes of this Agreement, Executive shall have “Good Reason” for resignation from employment with
the Company if any of the following actions are taken by the Company without Executive’s prior written consent: (a) a material
reduction in Executive’s Base Salary, which the parties agree is a reduction of at least ten percent (10%) of Executive’s
Base Salary (unless pursuant to a salary reduction program applicable generally to the Company’s similarly situated employees);
(b) a material reduction in Executive’s duties (including responsibilities and/or authorities), provided, however, that,
solely following a Change of Control, a change in job position (including a change in title) shall not be deemed a “material reduction”
in and of itself unless Executive’s new duties are materially reduced from the prior duties; or (c) relocation of Executive’s
principal place of employment to a place that increases Executive’s one-way commute by more than fifty (50) miles as compared to
Executive’s then-current principal place of employment immediately prior to such relocation. In order to resign his employment
for Good Reason, Executive must provide written notice to the Company’s Board within thirty (30) days after the first occurrence
of the event giving rise to Good Reason setting forth the basis for Executive’s resignation, allow the Company at least thirty
(30) days from receipt of such written notice to cure such event, and if such event is not reasonably cured within such period, Executive
must resign from all positions Executive then holds with the Company not later than ninety (90) days after the expiration of the cure
period.
11. Proprietary
Information Obligations.
11.1 Confidential
Information Agreement. As a condition of employment, Executive shall execute and abide by the Company’s standard form of Employee
Confidential Information and Inventions Assignment Agreement (the “Confidentiality Agreement”).
11.2 Third-Party
Agreements and Information. Executive represents and warrants that Executive’s employment by the Company does not conflict
with any prior employment or consulting agreement or other agreement with any third party, and that Executive will perform Executive’s
duties to the Company without violating any such agreement. Executive represents and warrants that Executive does not possess confidential
information arising out of prior employment, consulting, or other third party relationships, that would be used in connection with Executive’s
employment by the Company, except as expressly authorized by that third party. During Executive’s employment by the Company, Executive
will use in the performance of Executive’s duties only information which is generally known and used by persons with training and
experience comparable to Executive’s own, common knowledge in the industry, otherwise legally in the public domain, or obtained
or developed by the Company or by Executive in the course of Executive’s work for the Company.
12. Outside
Activities During Employment.
12.1 Non-Company
Business. Except with the prior written consent of the CEO, Executive will not during the term of Executive’s employment with
the Company undertake or engage in any other employment, occupation or business enterprise, other than ones in which Executive is a passive
investor. Executive may engage in civic and not-for-profit activities so long as such activities do not materially interfere with the
performance of Executive’s duties hereunder.
12.2 No
Adverse Interests. Executive agrees not to acquire, assume or participate in, directly or indirectly, any position, investment or
interest known to be adverse or antagonistic to the Company, its business or prospects, financial or otherwise.
13. Dispute
Resolution. To ensure the timely and economical resolution of disputes that may arise in connection
with Executive’s employment with the Company, Executive and the Company agree that any and all disputes, claims, or causes of action,
in law or in equity, arising from or relating to the enforcement, breach, performance, negotiation, execution, or interpretation of this
Agreement, Executive’s employment, or the termination of Executive’s employment, including but not limited to statutory claims,
shall be resolved pursuant to the Federal Arbitration Act, 9 U.S.C. §1-16 and to the fullest extent permitted by law by final, binding
and confidential arbitration, by a single arbitrator, in San Francisco, California, conducted by JAMS, Inc. (“JAMS”)
under the then applicable JAMS rules and procedures for employment disputes (available upon request and also currently available
at http://www.jamsadr.com/rules-employment-arbitration/). By agreeing to this arbitration procedure,
both Executive and the Company waive the right to resolve any such dispute through a trial by jury or judge or administrative proceeding.
The Company acknowledges that Executive will have the right to be represented by legal counsel at any
arbitration proceeding. In addition, all claims, disputes, or causes of action under this Paragraph, whether by Executive or the Company,
must be brought in an individual capacity, and shall not be brought as a plaintiff (or claimant) or class member in any purported class
or representative proceeding, nor joined or consolidated with the claims of any other person or entity. The arbitrator may not consolidate
the claims of more than one person or entity, and may not preside over any form of representative or class proceeding. To the extent
that the preceding sentences regarding class claims or proceedings are found to violate applicable law or are otherwise found unenforceable,
any claim(s) alleged or brought on behalf of a class shall proceed in a court of law rather than by arbitration. This paragraph shall
not apply to an action or claim brought in court pursuant to the California Private Attorneys General Act of 2004, as amended. The arbitrator
shall: (a) have the authority to compel adequate discovery for the resolution of the dispute and to award such relief as would otherwise
be permitted by law; and (b) issue a written arbitration decision, to include the arbitrator’s essential findings and conclusions
and a statement of the award. The arbitrator shall be authorized to award any or all remedies that Executive or the Company would be
entitled to seek in a court of law. The Company shall pay all JAMS’ arbitration fees in excess of the amount of court fees that
would be required of Executive if the dispute were decided in a court of law. Nothing in this Agreement is intended to prevent either
Executive or the Company from obtaining injunctive relief in court to prevent irreparable harm pending the conclusion of any such arbitration.
Any awards or orders in such arbitrations may be entered and enforced as judgments in the federal and state courts of any competent jurisdiction.
14. General
Provisions.
14.1 Notices.
Any notices provided must be in writing and will be deemed effective upon the earlier of personal delivery (including personal delivery
by fax) or the next day after sending by overnight carrier, to the Company at its primary office location and to Executive at the address
as listed on the Company payroll.
14.2 Severability.
Whenever possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid under applicable
law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or
rule in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other provision or any other jurisdiction,
but this Agreement will be reformed, construed and enforced in such jurisdiction to the extent possible in keeping with the intent of
the parties.
14.3 Waiver.
Any waiver of any breach of any provisions of this Agreement must be in writing to be effective, and it shall not thereby be deemed
to have waived any preceding or succeeding breach of the same or any other provision of this Agreement.
14.4 Complete
Agreement. This Agreement, together with the Confidentiality Agreement, constitutes the entire agreement between Executive and the
Company with regard to this subject matter and is the complete, final, and exclusive embodiment of the Parties’ agreement with
regard to this subject matter. This Agreement is entered into without reliance on any promise or representation, written or oral, other
than those expressly contained herein, and it supersedes any other such promises, warranties or representations. This Agreement cannot
be modified or amended except in a writing signed by a duly authorized officer of the Company.
14.5 Counterparts.
This Agreement may be executed and delivered in separate counterparts, any one of which need not contain signatures of more than
one party, but all of which taken together will constitute one and the same Agreement, and delivery via facsimile, electronic mail (including
pdf or any electronic signature complying with the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions Act or other applicable
law) or other transmission method and shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.
14.6 Headings.
The headings of the paragraphs hereof are inserted for convenience only and shall not be deemed to constitute a part hereof nor to
affect the meaning thereof.
14.7 Successors
and Assigns. This Agreement is intended to bind and inure to the benefit of and be enforceable by Executive and the Company, and
their respective successors, assigns, heirs, executors and administrators, except that Executive may not assign any of his duties hereunder
and he may not assign any of his rights hereunder without the written consent of the Company, which shall not be withheld unreasonably.
14.8 Tax
Withholding and Indemnification. All payments and awards contemplated or made pursuant to this Agreement will be subject to withholdings
of applicable taxes in compliance with all relevant laws and regulations of all appropriate government authorities. Executive acknowledges
and agrees that the Company has neither made any assurances nor any guarantees concerning the tax treatment of any payments or awards
contemplated by or made pursuant to this Agreement. Executive has had the opportunity to retain a tax and financial advisor and fully
understands the tax and economic consequences of all payments and awards made pursuant to the Agreement.
14.9 Choice
of Law. All questions concerning the construction, validity and interpretation of this Agreement will be governed by the laws of
the State of California.
In
Witness Whereof, the Parties have executed this
Agreement on the day and year first written above.
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CERO Therapeutic Holdings, Inc. |
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By: |
/s/
Chris Ehrlich |
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Chris Ehrlich |
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Vice Chairman – Board
of Directors |
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Executive |
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Brian G. Atwood |
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EMPLOYEE |
9.
Exhibit 10.16
CERO
THERAPEUTIC HOLDINGS, INC.
EXECUTIVE EMPLOYMENT AGREEMENT
for
EMPLOYEE
This Executive Employment
Agreement (the “Agreement”), made between CERO Therapeutic Holdings, Inc. (the “Company”) and
Charles R. Carter (the “Executive”) (collectively, the “Parties”), is effective as of March 26,
2024 (“Effective Date”).
Whereas,
the Company desires for Executive to provide services to the Company, and wishes to provide Executive with certain compensation and benefits
in return for such services, as set forth in this Agreement; and
Whereas,
Executive wishes to be employed by the Company and to provide personal services to the Company in return for certain compensation and
benefits, as set forth in this Agreement;
Now,
Therefore, in consideration of the mutual promises and covenants contained herein and for other good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged, the Parties hereto agree as follows:
1. Employment
by the Company.
1.1 Position.
Executive shall serve as the Company’s Chief Financial Officer and Corporate Secretary. During the term of Executive’s employment
with the Company, Executive will devote Executive’s best efforts and substantially all of Executive’s business time and attention
to the business of the Company, except for approved vacation periods and reasonable periods of illness or other incapacities permitted
by the Company’s general employment policies.
1.2 Duties
and Location. Executive shall perform such duties as are required by the Company’s Board of Directors (the “Board”),
to whom Executive will report. Executive’s primary office location shall be the Company’s California office, although remote
locations are acceptable unless and until the board of directors indicates otherwise. The Company reserves the right to reasonably require
Executive to perform Executive’s duties at places other than Executive’s primary office location from time to time, and to
require reasonable business travel. The Company may modify Executive’s job title and duties as it deems necessary and appropriate
in light of the Company’s needs and interests from time to time.
1.3 Policies
and Procedures. The employment relationship between the Parties shall be governed by the general employment policies and practices
of the Company, as adopted or modified from time to time in the Company’s discretion, except that when the terms of this Agreement
differ from or are in conflict with the Company’s general employment policies or practices, this Agreement shall control.
2. Compensation.
2.1 Salary.
For services to be rendered hereunder, Executive shall receive a base salary at the rate of three hundred fifty thousand dollars ($350,000)
per year (the “Base Salary”), subject to standard payroll deductions and withholdings and payable in accordance with
the Company’s regular payroll schedule. As an exempt salaried employee, Executive will be required to work the Company’s normal
business hours, and such additional time as appropriate for Executive’s work assignments and position, and Executive will not be
entitled to overtime compensation.
2.2
Bonus. Executive will be eligible for an annual discretionary bonus of up to thirty-five percent (35%) of Executive’s Base
Salary (the “Annual Bonus”), under the terms herein and the Company’s written bonus plan applicable to Executives.
Whether Executive receives an Annual Bonus for any given year, and the amount of any such Annual Bonus, will be determined by the Board
in its sole discretion based upon the Company’s and Executive’s achievement of objectives and milestones to be determined
on an annual basis by the Board. Executive must remain an active employee through the end of any given calendar year in order to earn
an Annual Bonus for that year and any such bonus will be paid prior to March 15 of the calendar year after the applicable bonus year.
Executive will not be eligible for, and will not earn, any Annual Bonus (including a prorated bonus) if Executive’s employment
terminates for any reason before the end of the calendar year.
3.
Standard Company Benefits. Executive
shall be entitled to participate in all employee benefit programs for which Executive is eligible under the terms and conditions of the
benefit plans and applicable policies that may be in effect from time to time and provided by the Company to its employees, including
but not limited to: medical, dental and vision insurance; life insurance; short-term and long-term disability insurance; 401(k) plan;
and the ability to take time off with pay within Executive’s discretion pursuant to the Company’s nonaccrual paid time off
policy for exempt employees. The Company reserves the right to cancel or change the benefit plans or programs it offers to its employees
at any time.
4.
Expenses. The Company will reimburse
Executive for reasonable travel, entertainment or other expenses incurred by Executive in furtherance or in connection with the performance
of Executive’s duties hereunder, in accordance with the Company’s expense reimbursement policy as in effect from time to
time.
5.
Equity. Subject to approval by the
Board (which will be sought promptly following Executive’s joining the Company as its CEO), Executive shall be granted an option
to purchase 395,387 shares (representing 1.5% of the Company’s Common Stock, calculated on a fully diluted, as-converted basis,
excluding the 2024 equity incentive plan and 2024 employee stock purchase plan reserves as of immediately after the grant), with an exercise
price equal to the fair market value as determined by the Board on the date of grant (the “Option”).
The Option will be subject to vesting in forty-eight (48) equal monthly installments, in each case subject to Executive’s continued
employment through the applicable vesting dates. The Option shall be governed in all respects by the terms of the governing plan documents
and option or stock purchase agreement between Executive and the Company.
6.
Termination of Employment; Severance.
6.1
At-Will Employment. Executive’s employment relationship is at-will. Either Executive or the Company may terminate the employment
relationship at any time, with or without Cause (as defined below) or advance notice.
6.2
Termination Without Cause; Resignation for Good Reason.
(i)
The Company may terminate Executive’s employment with the Company at any time without Cause. Further, Executive may resign
his employment at any time for Good Reason (as defined below).
(ii)
In the event Executive’s employment with the Company is terminated by the Company without Cause (other than as a result of
Executive’s death or disability), or Executive resigns his employment for Good Reason, in either case prior to the thirty (30)-day
period prior to the closing of a Change of Control (as defined below) or more than twelve (12) months following the closing of a Change
of Control, then provided such termination constitutes a “separation from service” (as defined under Treasury Regulation
Section 1.409A-1(h), without regard to any alternative definition thereunder, a “Separation from Service”), then subject
to Paragraph 7 (“Conditions to Receipt of Severance, Special Cash Payments and Accelerated Vesting”) and Executive’s
continued compliance with the terms of this Agreement (including the Confidentiality Agreement), the Company shall provide Executive
with the following severance benefits:
(a)
Executive shall be entitled to receive Executive’s monthly base salary as in effect immediately prior to the Separation Date
for an additional nine (9) months after the Separation Date in accordance with the Company’s usual payroll practices (and
in any event no less frequently than monthly, although subject to the provisions of Sections 4(e) and 10(o) below), with the first installment
commencing on the first payroll date that is sixty (60) days following the Separation Date (and any installment payments which would
otherwise have been paid to Executive before the sixtieth (60th) day following the Separation
Date will be paid together with the first installment); and
(b)
For the period beginning on the Separation Date and ending on the date which is nine (9) full months following the Separation
Date (or, if earlier, the date on which the applicable continuation period under COBRA expires), the Company shall arrange to provide
or pay the applicable premiums for Executive and his or her eligible dependents who were covered under the Company’s health insurance
plans as of the Separation Date with health (including medical and dental) insurance benefits substantially similar to those provided
to Executive and his or her dependents immediately prior to the Separation Date. Notwithstanding the previous sentence, with regard to
such COBRA continuation coverage, if the Company determines in its sole discretion that it cannot provide the foregoing benefit without
potentially violating applicable law (including, without limitation, Section 2716 of the Public Health Service Act), the Company
shall in lieu thereof provide to the Executive a taxable monthly payment in an amount equal to the monthly COBRA premium that the Executive
would be required to pay to continue the Executive’s and his or her covered dependents’ group insurance coverages in effect
on the Separation Date (which amount shall be based on the premiums for the first month of COBRA coverage).
(iii)
If the Company terminates Executive’s employment with the Company without Cause (other than as a result of Executive’s
death or disability), or Executive resigns his employment for Good Reason, in either case within thirty (30) days prior to or twelve
(12) months following the closing of a Change of Control, then:
(a)
Executive shall be entitled to receive Executive’s monthly base salary as in effect immediately prior to the Separation Date
for an additional twelve (12) months after the Separation Date in accordance with the Company’s usual payroll practices (and
in any event no less frequently than monthly, although subject to the provisions of Sections 4(e) and 10(o) below), with the first installment
commencing on the first payroll date that is sixty (60) days following the Separation Date (and any installment payments which would
otherwise have been paid to Executive before the sixtieth (60th) day following the Separation
Date will be paid together with the first installment); and
(b)
For the period beginning on the Separation Date and ending on the date which is twelve (12) full months following the Separation
Date (or, if earlier, the date on which the applicable continuation period under COBRA expires), the Company shall arrange to provide
or pay the applicable premiums for Executive and his or her eligible dependents who were covered under the Company’s health insurance
plans as of the Separation Date with health (including medical and dental) insurance benefits substantially similar to those provided
to Executive and his or her dependents immediately prior to the Separation Date. Notwithstanding the previous sentence, with regard to
such COBRA continuation coverage, if the Company determines in its sole discretion that it cannot provide the foregoing benefit without
potentially violating applicable law (including, without limitation, Section 2716 of the Public Health Service Act), the Company
shall in lieu thereof provide to the Executive a taxable monthly payment in an amount equal to the monthly COBRA premium that the Executive
would be required to pay to continue the Executive’s and his or her covered dependents’ group insurance coverages in effect
on the Separation Date (which amount shall be based on the premiums for the first month of COBRA coverage).
(c)
Executive shall be entitled to receive an amount equal to (A) the annual total Target Bonus amount for the year in which Executive’s
Separation from Service occurs, with such payment occurring on the first payroll date that is sixty (60) days following the Separation
Date (but no later than March 15 of the calendar year following the calendar year in which the Separation Date occurs); and
(d)
accelerate the vesting of all outstanding unvested equity awards granted to Executive, including but not limited to the Option, such
that one hundred percent (100%) of such equity awards shall be deemed immediately vested and exercisable (if applicable) as of Executive’s
last day of employment (the “Change of Control Accelerated Vesting”). The foregoing provisions are hereby deemed to
be a part of each Stock Award and to supersede any less favorable provision in any agreement or plan regarding such Stock Award.
(iv)
accelerate the vesting of all outstanding unvested If Executive’s employment with the Company terminates as a result of Executive’s
death or disability, the Company shall accelerate the vesting of fifty percent (50%) of the outstanding then-unvested equity awards granted
to Executive, including but not limited to the Option, as of Executive’s last day of employment (the “Unforeseen Events
Accelerated Vesting,” and either the Change of Control Accelerated Vesting or the Unforeseen Events Acceleration, the “Accelerated
Vesting”), it being acknowledged and agreed that, other than the Unforeseen Events Accelerated Vesting, Executive shall not
be entitled to any Severance, COBRA Premiums (or Special Cash Payments) if Executive’s employment with the Company terminates as
a result of Executive’s death or disability.
6.3
Termination for Cause; Resignation Without Good Reason; Death or Disability.
(i)
The Company may terminate Executive’s employment with the Company at any time for Cause. Further, Executive may resign his
employment at any time without Good Reason. Executive’s employment with the Company may also be terminated due to Executive’s
death or disability.
(ii)
If Executive resigns his employment without Good Reason, or the Company terminates Executive’s employment for Cause, or if
Executive’s employment terminates as a result of Executive’s death or disability, then except as set forth as to Unforeseen
Events Acceleration above, (a) Executive will no longer vest in the Stock Awards or any other equity awards, (b) all payments of compensation
by the Company to Executive hereunder will terminate immediately (except as to amounts already earned), and (c) Executive will not be
entitled to any severance benefits, including (without limitation) the Severance, Special Cash Payments or Accelerated Vesting. In addition,
Executive shall resign from all positions and terminate any relationships as an employee, advisor, officer or director with the Company
and any of its affiliates, each effective on the date of employment termination.
7.
Conditions to Receipt of Severance, Special Cash Payments and Accelerated
Vesting. The receipt of the Severance, Special Cash Payments and Accelerated Vesting will be subject
to Executive signing and not revoking a separation agreement and release of claims in a form reasonably satisfactory to the Company within
sixty (60) days following the date of Executive’s Separation from Service (the “Separation Agreement”).
No Severance, Special Cash Payments or Accelerated Vesting will be paid or provided until the Separation Agreement becomes effective.
Executive shall also resign from all positions and terminate any relationships as an employee, advisor, officer or director with the
Company and any of its affiliates, each effective on the date of employment termination.
8. Section
409A. It is intended that all of the severance benefits and other payments payable under this Agreement
satisfy, to the greatest extent possible, the exemptions from the application of Section 409A of the Internal Revenue Code of 1986, as
amended (the “Code”) (Section 409A, together with any state law of similar effect,
“Section 409A”) provided under Treasury Regulations 1.409A-1(b)(4), 1.409A-1(b)(5)
and 1.409A-1(b)(9), and this Agreement will be construed to the greatest extent possible as consistent with those provisions, and to
the extent not so exempt, this Agreement (and any definitions hereunder) will be construed in a manner that complies with Section 409A.
For purposes of Section 409A (including, without limitation, for purposes of Treasury Regulation Section 1.409A-2(b)(2)(iii)), Executive’s
right to receive any installment payments under this Agreement (whether severance payments, reimbursements or otherwise) shall be treated
as a right to receive a series of separate payments and, accordingly, each installment payment hereunder shall at all times be considered
a separate and distinct payment. Notwithstanding any provision to the contrary in this Agreement, if Executive is deemed by the Company
at the time of Executive’s Separation from Service to be a “specified employee” for purposes of Section 409A(a)(2)(B)(i),
and if any of the payments upon Separation from Service set forth herein and/or under any other agreement with the Company are deemed
to be “deferred compensation”, then to the extent delayed commencement of any portion of such payments is required in order
to avoid a prohibited distribution under Section 409A(a)(2)(B)(i) and the related adverse taxation under Section 409A, such payments
shall not be provided to Executive prior to the earliest of (i) the expiration of the six (6)-month period measured from the date of
Executive’s Separation from Service with the Company, (ii) the date of Executive’s death or (iii) such earlier date as permitted
under Section 409A without the imposition of adverse taxation. Upon the first business day following the expiration of such applicable
Section 409A(a)(2)(B)(i) period, all payments deferred pursuant to this Paragraph shall be paid in a lump sum to Executive, and any remaining
payments due shall be paid as otherwise provided herein or in the applicable agreement. No interest shall be due on any amounts so deferred.
If any of the severance benefits set forth herein are not covered by one or more exemptions from the application of Section 409A and
the Separation Agreement could become effective in the calendar year following the calendar year in which Executive has a Separation
from Service, the Separation Agreement will not be deemed effective any earlier than the Effective Date set forth in such Separation
Agreement. The severance benefits set forth herein are intended to qualify for an exemption from application of Section 409A or comply
with its requirements to the extent necessary to avoid adverse personal tax consequences under Section 409A, and any ambiguities herein
shall be interpreted accordingly. Notwithstanding anything to the contrary herein, to the extent required to comply with Section 409A,
a termination of employment shall not be deemed to have occurred for purposes of any provision of this Agreement providing for the payment
of amounts or benefits upon or following a termination of employment unless such termination is also a “separation from service”
within the meaning of Section 409A. With respect to reimbursements or in-kind benefits provided to Executive hereunder (or otherwise)
that are not exempt from Section 409A, the following rules shall apply: (i) the amount of expenses eligible for reimbursement, or in-kind
benefits provided, during any one of Executive’s taxable years shall not affect the expenses eligible for reimbursement, or in-kind
benefit to be provided in any other taxable year, (ii) in the case of any reimbursements of eligible expenses, reimbursement shall be
made on or before the last day of Executive’s taxable year following the taxable year in which the expense was incurred, (iii)
the right to reimbursement or in-kind benefits shall not be subject to liquidation or exchange for another benefit.
9.
Section 280G; Parachute Payments.
9.1
If any payment or benefit Executive will or may receive from the Company or otherwise (a “280G Payment”) would
(i) constitute a “parachute payment” within the meaning of Section 280G of the Code, and (ii) but for this sentence,
be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then any such 280G Payment provided
pursuant to this Agreement (a “Payment”) shall be equal to the Reduced Amount. The “Reduced Amount” shall
be either (x) the largest portion of the Payment that would result in no portion of the Payment (after reduction) being subject to the
Excise Tax or (y) the largest portion, up to and including the total, of the Payment, whichever amount (i.e., the amount determined by
clause (x) or by clause (y)), after taking into account all applicable federal, state and local employment taxes, income taxes, and the
Excise Tax (all computed at the highest applicable marginal rate), results in Executive’s receipt, on an after-tax basis, of the
greater economic benefit notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in
a Payment is required pursuant to the preceding sentence and the Reduced Amount is determined pursuant to clause (x) of the preceding
sentence, the reduction shall occur in the manner (the “Reduction Method”) that results in the greatest economic benefit
for Executive. If more than one method of reduction will result in the same economic benefit, the items so reduced will be reduced pro
rata (the “Pro Rata Reduction Method”).
9.2
Notwithstanding any provision of Section 9.1 above to the contrary, if the Reduction Method or the Pro Rata Reduction Method would
result in any portion of the Payment being subject to taxes pursuant to Section 409A that would not otherwise be subject to taxes pursuant
to Section 409A, then the Reduction Method and/or the Pro Rata Reduction Method, as the case may be, shall be modified so as to avoid
the imposition of taxes pursuant to Section 409A as follows: (A) as a first priority, the modification shall preserve to the greatest
extent possible, the greatest economic benefit for Executive as determined on an after-tax basis; (B) as a second priority, Payments
that are contingent on future events (e.g., being terminated without Cause), shall be reduced (or eliminated) before Payments that are
not contingent on future events; and (C) as a third priority, Payments that are “deferred compensation” within the meaning
of Section 409A shall be reduced (or eliminated) before Payments that are not deferred compensation within the meaning of Section 409A.
9.3
Unless Executive and the Company agree on an alternative accounting firm or law firm, the accounting firm engaged by the Company
for general tax compliance purposes as of the day prior to the effective date of the Change in Control transaction shall perform the
foregoing calculations. If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity
or group effecting the change in control transaction, the Company shall appoint a nationally recognized accounting or law firm to make
the determinations required by this Section 9 (“Section 280G; Parachute Payments”). The Company shall bear all expenses
with respect to the determinations by such accounting or law firm required to be made hereunder. The Company shall use commercially reasonable
efforts to cause the accounting or law firm engaged to make the determinations hereunder to provide its calculations, together with detailed
supporting documentation, to Executive and the Company within fifteen (15) calendar days after the date on which Executive’s right
to a 280G Payment becomes reasonably likely to occur (if requested at that time by Executive or the Company) or such other time as requested
by Executive or the Company.
9.4
If Executive receives a Payment for which the Reduced Amount was determined pursuant to clause (x) of Section 9.1 and the Internal
Revenue Service determines thereafter that some portion of the Payment is subject to the Excise Tax, Executive agrees to promptly return
to the Company a sufficient amount of the Payment (after reduction pursuant to clause (x) of Section 9.1) so that no portion of the remaining
Payment is subject to the Excise Tax. For the avoidance of doubt, if the Reduced Amount was determined pursuant to clause (y) of Section
9.1, Executive shall have no obligation to return any portion of the Payment pursuant to the preceding sentence.
10.
Definitions.
(i)
Cause. For purposes of this Agreement, “Cause” for termination will mean: (a) commission of any felony or crime
involving dishonesty; (b) participation in any fraud against the Company; (c) material breach of Executive’s duties to the Company;
(d) intentional damage to any property of the Company; (e) misconduct, or other violation of Company policy that causes harm; (f) breach
of any written agreement with the Company; and
(g) conduct by Executive which in the good faith and reasonable determination of the Board demonstrates gross unfitness to serve.
(ii)
Change of Control. For purposes of this Agreement, “Change of Control” shall mean either an “Asset Transfer”
of “Acquisition,” as those terms are defined in the Company’s Amended and Restated Certificate of Incorporation as
in effect on the applicable date of the Change of Control.
(iii)
Good Reason. For purposes of this Agreement, Executive shall have “Good Reason” for resignation from employment
with the Company if any of the following actions are taken by the Company without Executive’s prior written consent: (a) a material
reduction in Executive’s Base Salary, which the parties agree is a reduction of at least ten percent (10%) of Executive’s
Base Salary (unless pursuant to a salary reduction program applicable generally to the Company’s similarly situated employees);
(b) a material reduction in Executive’s duties (including responsibilities and/or authorities), provided, however, that,
solely following a Change of Control, a change in job position (including a change in title) shall not be deemed a “material reduction”
in and of itself unless Executive’s new duties are materially reduced from the prior duties; or (c) relocation of Executive’s
principal place of employment to a place that increases Executive’s one-way commute by more than fifty (50) miles as compared to
Executive’s then-current principal place of employment immediately prior to such relocation. In order to resign his employment
for Good Reason, Executive must provide written notice to the Company’s Board within thirty (30) days after the first occurrence
of the event giving rise to Good Reason setting forth the basis for Executive’s resignation, allow the Company at least thirty
(30) days from receipt of such written notice to cure such event, and if such event is not reasonably cured within such period, Executive
must resign from all positions Executive then holds with the Company not later than ninety (90) days after the expiration of the cure
period.
11.
Proprietary Information Obligations.
11.1
Confidential Information Agreement. As a condition of employment, Executive shall execute and abide by the Company’s standard
form of Employee Confidential Information and Inventions Assignment Agreement (the “Confidentiality Agreement”).
11.2
Third-Party Agreements and Information. Executive represents and warrants that Executive’s employment by the Company does not
conflict with any prior employment or consulting agreement or other agreement with any third party, and that Executive will perform Executive’s
duties to the Company without violating any such agreement. Executive represents and warrants that Executive does not possess confidential
information arising out of prior employment, consulting, or other third party relationships, that would be used in connection with Executive’s
employment by the Company, except as expressly authorized by that third party. During Executive’s employment by the Company, Executive
will use in the performance of Executive’s duties only information which is generally known and used by persons with training and
experience comparable to Executive’s own, common knowledge in the industry, otherwise legally in the public domain, or obtained
or developed by the Company or by Executive in the course of Executive’s work for the Company.
12.
Outside Activities During Employment.
12.1
Non-Company Business. Except with the prior written consent of the CEO, Executive will not during the term of Executive’s employment
with the Company undertake or engage in any other employment, occupation or business enterprise, other than ones in which Executive is
a passive investor and Executive agrees that he or she will not join any boards, other than community and civic boards (which do not
interfere with his or her duties to the Company), without the prior approval of the Chief Executive Officer or the Board. Executive may
engage in civic and not-for-profit activities so long as such activities do not materially interfere with the performance of Executive’s
duties hereunder.
12.2
No Adverse Interests. Executive agrees not to acquire, assume or participate in, directly or indirectly, any position, investment
or interest known to be adverse or antagonistic to the Company, its business or prospects, financial or otherwise.
13.
Dispute Resolution. To ensure the timely
and economical resolution of disputes that may arise in connection with Executive’s employment with the Company, Executive and
the Company agree that any and all disputes, claims, or causes of action, in law or in equity, arising from or relating to the enforcement,
breach, performance, negotiation, execution, or interpretation of this Agreement, Executive’s employment, or the termination of
Executive’s employment, including but not limited to statutory claims, shall be resolved pursuant to the Federal Arbitration Act,
9 U.S.C. §1-16 and to the fullest extent permitted by law by final, binding and confidential arbitration, by a single arbitrator,
in San Francisco, California, conducted by JAMS, Inc. (“JAMS”) under the then applicable
JAMS rules and procedures for employment disputes (available upon request and also currently available at http://www.jamsadr.com/rules-employment-arbitration/).
By agreeing to this arbitration procedure, both Executive and the Company waive the right to resolve any such dispute through
a trial by jury or judge or administrative proceeding. The Company acknowledges that Executive will
have the right to be represented by legal counsel at any arbitration proceeding. In addition, all claims, disputes, or causes of action
under this Paragraph, whether by Executive or the Company, must be brought in an individual capacity, and shall not be brought as a plaintiff
(or claimant) or class member in any purported class or representative proceeding, nor joined or consolidated with the claims of any
other person or entity. The arbitrator may not consolidate the claims of more than one person or entity, and may not preside over any
form of representative or class proceeding. To the extent that the preceding sentences regarding class claims or proceedings are found
to violate applicable law or are otherwise found unenforceable, any claim(s) alleged or brought on behalf of a class shall proceed in
a court of law rather than by arbitration. This paragraph shall not apply to an action or claim brought in court pursuant to the California
Private Attorneys General Act of 2004, as amended. The arbitrator shall: (a) have the authority to compel adequate discovery for the
resolution of the dispute and to award such relief as would otherwise be permitted by law; and (b) issue a written arbitration decision,
to include the arbitrator’s essential findings and conclusions and a statement of the award. The arbitrator shall be authorized
to award any or all remedies that Executive or the Company would be entitled to seek in a court of law. The Company shall pay all JAMS’
arbitration fees in excess of the amount of court fees that would be required of Executive if the dispute were decided in a court of
law. Nothing in this Agreement is intended to prevent either Executive or the Company from obtaining injunctive relief in court to prevent
irreparable harm pending the conclusion of any such arbitration. Any awards or orders in such arbitrations may be entered and enforced
as judgments in the federal and state courts of any competent jurisdiction.
14.
General Provisions.
14.1
Notices. Any notices provided must be in writing and will be deemed effective upon the earlier of personal delivery (including personal
delivery by fax) or the next day after sending by overnight carrier, to the Company at its primary office location and to Executive at
the address as listed on the Company payroll.
14.2
Severability. Whenever possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid
under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any
applicable law or rule in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other provision or any
other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction to the extent possible in keeping
with the intent of the parties.
14.3
Waiver. Any waiver of any breach of any provisions of this Agreement must be in writing to be effective, and it shall not thereby
be deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement.
14.4
Complete Agreement. This Agreement, together with the Confidentiality Agreement, constitutes the entire agreement between Executive
and the Company with regard to this subject matter and is the complete, final, and exclusive embodiment of the Parties’ agreement
with regard to this subject matter. This Agreement is entered into without reliance on any promise or representation, written or oral,
other than those expressly contained herein, and it supersedes any other such promises, warranties or representations. This Agreement
cannot be modified or amended except in a writing signed by a duly authorized officer of the Company.
14.5
Counterparts. This Agreement may be executed and delivered in separate counterparts, any one of which need not contain signatures
of more than one party, but all of which taken together will constitute one and the same Agreement, and delivery via facsimile, electronic
mail (including pdf or any electronic signature complying with the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions Act
or other applicable law) or other transmission method and shall be deemed to have been duly and validly delivered and be valid and effective
for all purposes.
14.6
Headings. The headings of the paragraphs hereof are inserted for convenience only and shall not be deemed to constitute a part hereof
nor to affect the meaning thereof.
14.7
Successors and Assigns. This Agreement is intended to bind and inure to the benefit of and be enforceable by Executive and the Company,
and their respective successors, assigns, heirs, executors and administrators, except that Executive may not assign any of his duties
hereunder and he may not assign any of his rights hereunder without the written consent of the Company, which shall not be withheld unreasonably.
14.8 Tax
Withholding and Indemnification. All payments and awards contemplated or made pursuant to this Agreement will be subject to withholdings
of applicable taxes in compliance with all relevant laws and regulations of all appropriate government authorities. Executive acknowledges
and agrees that the Company has neither made any assurances nor any guarantees concerning the tax treatment of any payments or awards
contemplated by or made pursuant to this Agreement. Executive has had the opportunity to retain a tax and financial advisor and fully
understands the tax and economic consequences of all payments and awards made pursuant to the Agreement.
14.9
Choice of Law. All questions concerning the construction, validity and interpretation of this Agreement will be governed by the laws
of the State of California.
In
Witness Whereof, the Parties have executed this Agreement on the
day and year first written above.
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CERO
Therapeutic Holdings, Inc. |
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By: |
/s/
Chris Ehrlich |
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Chris Ehrlich |
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Vice Chairman – Board of Directors
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Executive |
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Charles R. Charter |
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EMPLOYEE |
10.
Exhibit 10.17
CERo Therapeutics Holdings, Inc.
March 28, 2024
Daniel Corey
Dear Daniel:
The Board of Directors (the
“Board”) of CERo Therapeutics Holdings, Inc. (the “Company”) and its lead investors are excited
about the prospect of your continued employment with a world-class team that we are building. This letter agreement (“Agreement”)
sets forth the terms and conditions of your employment as of the closing of the Company’s business combination pursuant to that
certain Business Combination Agreement, dated as of June 4, 2023, by and among the Company (then known as Phoenix Biotech Acquisition
Corp.), CERo Therapeutics, Inc. (“CERo”), PBCE Merger Sub, Inc., a Delaware corporation and a direct wholly
owned subsidiary of the Company, pursuant to which CERo became a wholly-owned subsidiary of the Company and the Company was renamed CERo
Therapeutics Holdings, Inc., as amended by Amendment No. 1 thereto, dated as of March 28, 2024 (the “Effective Date”).
1. Position.
Your title will be Chief Technology Officer and Founder of the Company, and you will undertake those responsibilities and have those powers
and authorities which are customarily associated with a Chief Technology Officer at a company in our industry and which is comparable
in size to the Company. You will report to the Chief Executive Officer (“C.E.O.”), and shall, among other things, undertake
and assume the responsibility of performing for and on behalf of the Company the duties set forth in Exhibit A to the Agreement and such
duties as shall be assigned to you at any time by the C.E.O. You agree to devote your best efforts and all of your business time and attention
to the business of the Company, except for vacation and holiday periods, periods of illness or other incapacities permitted by the Company’s
general employment policies, and as otherwise authorized herein. By signing this Agreement, you confirm to the Company that you have no
contractual commitments or other legal obligations that would prohibit or restrict you in any way from performing your duties for the
Company.
2. Board
of Directors. During your employment, you will be appointed to the Board and you agree to serve as a director of the Company. You
agree that in the event your employment with the Company is terminated for any reason, either voluntarily or involuntarily, with or without
Cause (as such term is defined herein), or you no longer serve as the Company’s Chief Technology Officer, your position as a member
of the Board shall simultaneously be terminated automatically without any further action required by either you or the Company. You will
not be provided with additional compensation relating to your role on the Board.
3. Compensation.
(a) Base
Salary. Your initial gross annual base salary will be $350,000 per year (the “Base Salary”), payable in accordance
with the Company’s standard payroll practices and which may be modified from time to time. The Base Salary shall be subject to annual
review by the Board or the Compensation Committee of the Board (the “Compensation Committee”).
(b) Annual
Discretionary Bonus. You will be eligible to earn an initial annual target bonus of up to fifty percent (50%) of your Base Salary
in effect during the bonus year (the “Bonus”). Whether your Bonus is earned, and the amount of the Bonus (if any),
will be determined by the Board or the Compensation Committee in its discretion based upon the Company’s annual target goals (as
adopted by the Board or the Compensation Committee), as well as the Board’s consideration of the Company’s then-current financial
condition. The Board or Compensation Committee, with your input, will determine applicable performance targets for each bonus year, which
may include individual goals, corporate financial goals and business development goals. In order to be eligible to earn your Bonus, you
must remain an employee of the Company through the end of the applicable work year and you will not earn any of your Bonus if your employment
terminates before the end of the applicable work year. Payment of the Bonus will be made within the first quarter following the end of
the applicable work year
(c) Stock
Option Grants. Reasonably promptly following the later of your signing this Agreement or the Effective Date, the Board or the Compensation
Committee will grant you an option to purchase 395,387 shares of the Company’s common stock (“Common Stock”)
(equal to 1.5% of the outstanding Common Stock on a fully-diluted basis) as of the Effective Date, which will be fully vested upon the
date of grant. The foregoing Option will be issued pursuant and subject to the Company’s 2024 Equity Incentive Plan. The exercise
price for each share of Common Stock subject to the foregoing Option will be equal to the fair market value per share of the Common Stock
on the date of grant of such Options, as determined by the Board or the Compensation Committee in its sole discretion. In addition, the
Company will grant to you an option to purchase up to an additional 461,284 shares of the Company’s Common Stock (equal to 1.75%
on a fully-diluted basis) (the “Performance Option”) as of the Effective Date that will vest upon achievement of the
milestone listed below (for a total grant of 3.25%):
Milestone – The acceptance
by the Company of an Investigational New Drug application with the Food and Drug Administration for CER-1236 prior to the first anniversary
of the Effective Date.
Any portion of the Performance
Option relating to a Milestone not achieved within the time frame specified above shall be forfeited. The Performance Option will be issued
pursuant and subject to the Company’s 2024 Stock Option and Incentive Plan. The exercise price for each share of Common Stock subject
to the Performance Option will be equal to the fair market value per share of the Common Stock on the date of grant of such Options, as
determined by the Board or the Compensation Committee in its sole discretion.
4. Employee
Benefits. As an employee of the Company, you will be eligible to participate in all of the Company-sponsored benefits including health
insurance coverage for you and your dependents that will be provided to the Company’s senior executives generally. The Company reserves
the right to modify, change, or discontinue all or part of these benefits at any time at its sole discretion; provided, however you will
be entitled to those benefits provided to the Company’s senior executives generally. You are also entitled to four (4) weeks’
vacation per year.
5. Background
Screen. This employment offer is contingent upon successful results from background screening of any and all of your applicable driving
and criminal records and verification of your social security number, college degree(s), and recent employment.
6. Employee
Proprietary Information and Inventions Assignment Agreement. Like all Company employees, you will be required, as a condition of your
employment with the Company, to sign the Company’s standard Employee Proprietary Information and Inventions Assignment Agreement
(“PIIAA”).
7. Proof
of Authorization to Work in the United States. As required by law, your employment with the Company is contingent upon your providing
legal proof of your identity and authorization to work in the United States. Failure to provide proper identification may delay placement
on payroll and ultimately result in mandatory termination.
8. Employment
Relationship. Employment with the Company is for no specific period of time. Your employment with the Company will be “at will,”
meaning that either you or the Company may terminate your employment at any time and for any reason, with or without cause or advance
notice, and without any liability or obligation, except as specifically set forth herein. The “at will” nature of your employment
may only be changed in an express written agreement signed by you and the Chairman of the Board.
9. Termination
Without Cause. The Company may terminate your employment with the Company at any time without Cause (as hereinafter defined), upon
written notice to you and likewise, you may terminate your employment with the Company at any time upon written notice to the Company.
In the event your employment is terminated without Cause or you terminate for Good Reason (as hereinafter defined), and subject to the
conditions set forth in Section 13 below, the Company shall pay you as severance (“Severance”): (i) an amount equivalent
to the sum of four (4) months of your Base Salary, which length shall be increased by one month for each full year of employment from
the date hereof up to a maximum of six (6) months, and (ii) subject to your proper election to receive benefits under the Consolidated
Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”), the Company shall pay to the group health plan provider
or the COBRA provider a monthly payment equal to the monthly COBRA premium until the earliest of (A) the 6-month anniversary of the date
of termination; (B) the date you become eligible for group medical plan benefits under another employer’s group medical plan; or
(C) the cessation of your health continuation rights under COBRA; provided, however, at its option, the Company shall instead make such
payments directly to you in the form of payroll payments. Severance shall be subject to payroll withholding and deduction, and payable
upon the Company’s regular payroll schedule commencing within 60 days of the date of your termination; provided, however, that if
the 60-day period begins in one calendar year and ends in a second calendar year, such payments to the extent they qualify as “non-qualified
deferred compensation” within the meaning of Section 409A of the Code, shall be paid or commence to be paid in the second calendar
year by the last day of such 60-day period.
10. Termination
for Cause. The Company may terminate your employment with the Company at any time for Cause, determined in the Board’s discretion,
upon written notice to you. In the event your employment is terminated for Cause or as a result of your death or Disability, you will
not be entitled to Severance or any other such compensation or benefits, other than your Accrued Rights. “Accrued Rights”
shall mean (i) payment of any unpaid portion of your then-current Base Salary through the date of termination; (ii) reimbursement of any
approved business expenses yet to be reimbursed; (iii) any vested benefits to which you are entitled under the Company’s benefit
plans, policies, and procedures then in effect, and (iv) any unused and accrued vacation. For all purposes under this Agreement, “Cause”
shall mean: (i) your breach of this Agreement, the PIIAA, or any similar agreement with the Company, which breach is either incapable
of cure, or remains uncured for a period ten (10) days after prior written notice; (ii) your willful and continued failure to perform
the duties and responsibilities of your position, as set forth in Exhibit A; (iii) your engaging in any act of dishonesty, fraud or misrepresentation,
or misappropriating material property belonging to the Company or its affiliates; (iv) an adjudication or finding that you violated
federal or state law or regulation if such violation can reasonably be expected to have an adverse effect on your ability to perform your
obligations under this Agreement or on the Company’s business or reputation; (vi) your being convicted of, or entering a plea
of nolo contendere to, a felony or other crime involving moral turpitude, dishonesty, theft, fraud, or embezzlement; or (viii) misconduct
that would reasonably be expected to cause substantial reputational harm or substantial injury to the Employer if you were to continue
to be employed in the same position.
11. Termination
for Disability. The Company may terminate your employment if you are disabled and unable to perform or expected to be unable to perform
the essential functions of your position with or without reasonable accommodation for a period of 180 days (which need not be consecutive)
in any 12-month period (“Disability”). If any question shall arise as to whether during any period you are disabled
so as to be unable to perform the essential functions of your then-existing position with or without reasonable accommodation, you may,
and at the request of the Company shall, submit to the Company a certification in reasonable detail by a physician selected by the Company
as to whether you are so disabled or how long such disability is expected to continue, and such certification shall for the purposes of
this Agreement be conclusive of the issue. You shall cooperate with any reasonable request of the physician in connection with such certification.
If such question shall arise and you shall fail to submit such certification, the Company’s determination of such issue shall be
binding on you. Nothing in this section shall be construed to waive your rights, if any, under existing law including, without limitation,
the Family and Medical Leave Act of 1993, 29 U.S.C. §2601 et seq. and the Americans with Disabilities Act, 42 U.S.C. §12101
et seq.
12. Change
in Control. If the Company is: (a) subject to a Change in Control and (b) your employment is terminated by the Company
or successor corporation, as the case may be, without Cause (as defined herein), or you terminate your employment for Good Reason, in
either case, within ninety (90) days prior to the effective date of such Change in Control if the Company is in discussions with the potential
acquirer, or within twelve (12) months after the effective date of the Change in Control, then you shall receive immediate acceleration
of vesting of 100% of the then unvested options subject to time-based vesting. A “Change in Control” shall mean: (i) (A) any
consolidation or merger of the Company with or into any other corporation or other entity or person, or any other corporate reorganization,
other than any such consolidation, merger or reorganization in which the stockholders of the Company immediately prior to such consolidation,
merger or reorganization, continue to hold at least a majority of the voting power of the surviving entity (or if the surviving entity
is a wholly owned subsidiary, its parent) immediately after such consolidation, merger or reorganization; or (B) any transaction
or series of related transactions to which the Company is a party in which in excess of fifty percent (50%) of the Company’s voting
power is transferred (an “Acquisition”); provided, that an Acquisition shall not include any transaction or
series of transactions principally for bona fide equity financing purposes in which cash is received by the Company or any successor or
indebtedness of the Company is cancelled or converted into capital stock, or any combination thereof, or any transaction effected exclusively
to change the domicile of the Company, or (ii) a sale, lease, exclusive license or other disposition of all or substantially all
of the assets or intellectual property of the Company. “Good Reason” shall mean that you have followed the “Good
Reason Process” following any of the following events: (i) a material diminution in responsibilities, (ii) relocating
your principal place of business more than 50 miles from either the location of the Company’s executive offices or your primary
residence, or (iii) any material reduction in your then-current Base Salary, unless such reduction is part of a reduction in expenses
generally affecting senior executives of the Company. “Good Reason Process” means that (i) you reasonably determine
in good faith that a “Good Reason” condition has occurred; (ii) you notify the Company in writing of the first occurrence
of the Good Reason condition within 90 days of the first occurrence of such condition; (iii) you cooperate in good faith with the Company’s
efforts, for a period of up to 30 days following such notice (the “Cure Period”), to remedy the condition; and (iv)
notwithstanding such efforts, the Good Reason condition continues to exist following the Cure Period. If the Company cures the Good Reason
condition during the Cure Period, Good Reason shall be deemed not to have occurred.
13. Conditions
to the Receipt of Severance. The receipt of Severance pursuant to Section 9 will be subject to you: (i) remaining in compliance with
this Agreement and the PIIAA; and (ii) signing and not revoking a separation agreement and release of claims in a form acceptable to the
Company within 60 days following the date of termination (or such lesser period set forth in the separation agreement), as a condition
of receipt of any Severance under this Agreement. No Severance will be paid or provided until the separation agreement and release agreement
becomes effective.
14. Outside
Activities and Nonsolicitation. You will devote your full working time and efforts to the business and affairs of the Company. Notwithstanding
the foregoing, you may: (i) engage in clinical care of leukemia and lymphoma patients; and (ii) serve as a director on up to two boards
of directors of companies which do not compete with the Company (“Outside Activities”. All Outside Activities will
be disclosed to and approved by the Board (and such approval shall not be unreasonably withheld or delayed), do not interfere with the
your performance of the your duties to the Company or create a conflict of interest with respect to the Company. You shall review your
Outside Activieis with the Board on an annual basis and it is expected that any board appointment shall not require more than four (4)
in-person meetings per year. While you are employed by the Company and for a period of one (1) year thereafter, you will not engage in,
and will not assist any person or entity in, soliciting or recruiting away from the Company any employees or consultants of the Company.
15. Withholding
Taxes. All forms of compensation referred to in this Agreement are subject to reduction to reflect applicable withholding and payroll
taxes and other deductions required by law.
16. Arbitration.
You and the Company agree to waive any rights to a trial before a judge or jury, to the greatest extent allowed by law, and agree to arbitration
before a neutral arbitrator of any and all claims or disputes arising out of this Agreement and any and all claims arising from or relating
to your employment or relationship with the Company, including (but not limited to) claims against any current or former employee, director
or agent of the Company.
The arbitrator’s decision
must be written and must include the findings of fact and law that support the decision. The arbitrator’s decision will be final
and binding on both parties, except to the extent applicable law allows for judicial review of arbitration awards. The arbitrator may
award any remedies that would otherwise be available to the parties if they were to bring the dispute in court.
The arbitration will be conducted
in accordance with the JAMS Employment Arbitration Rules then in effect. These rules may be easily found through a web-based search,
or a copy may be requested at any time from Company. Claims shall be brought in arbitration on an individual basis only not as a plaintiff
or class member in any purported class proceeding or any purported representative proceeding. The arbitration shall be venued in
a mutually agreeable location, or if no such location can be agreed upon, within 45 miles of your residence within the U.S. at which you
primarily performed services for the Company.
You and the Company will share
the costs of arbitration equally, except that the Company will bear the cost of the arbitrator’s fee and any other type of expense
or cost that you would not be required to bear if you were to bring the dispute or claim in court. Both the Company and you will be responsible
for their costs and expenses, including, but not limited to, their own attorneys’ fees, and the arbitrator may not award attorneys’
fees unless a statute or contract at issue specifically authorizes such an award.
Either party shall be permitted
to seek injunctive relief in a court of proper jurisdiction in order to protect its rights until such time as judgment is entered
upon an arbitration award. Any argument as to the enforceability of these arbitration terms or the scope of these arbitration terms
are delegated to the arbitrator.
17. Governing
Law. This Agreement will be deemed to be made and entered into in the State of California, and will in all respects be interpreted,
enforced and governed under the laws of the State of California.
18. Severability.
The provisions of this Agreement shall be deemed severable, and the invalidity of any portion of this Agreement shall not affect the validity
of the remainder of this Agreement.
19. Assignment; Successors
and Assigns. Neither you nor the Company may make any assignment of this Agreement or any interest in it, by operation of law
or otherwise, without the prior written consent of the other; provided, however, that the Company may assign its rights and obligations
under this Agreement (including any agreements incorporated herein) without your consent to any affiliate or to any person or entity with
whom the Company shall hereafter effect a reorganization or consolidation, into which the Company merges or to whom it transfers all
or substantially all of its properties or assets; provided, further that if you remain employed or become employed by the Company,
the purchaser or any of their affiliates in connection with any such transaction, then you shall not be entitled to any Severance solely
as a result of such transaction. This Agreement shall inure to the benefit of and be binding upon you and the Company, and each of your
and the Company’s respective successors, executors, administrators, heirs and permitted assigns.
20. Survival.
The Parties’ respective rights and obligations under this Agreement shall survive any termination of your employment to the extent
necessary to preserve the intended rights and obligations.
21. Section
409A. The intent of the parties is that payments and benefits under this Agreement comply with Section 409A or an exception thereto,
and, accordingly, to the maximum extent permitted, this Agreement shall be interpreted to be in compliance therewith. Anything in this
Agreement to the contrary notwithstanding, if at the time of your separation from service within the meaning of Section 409A of the Code,
the Company determines you are a “specified employee” within the meaning of Section 409A(a)(2)(B)(i) of the Code, then to
the extent any payment or benefit that you become entitled to under this Agreement or otherwise on account of your separation from service
would be considered deferred compensation otherwise subject to the 20 percent additional tax imposed pursuant to Section 409A(a) of the
Code as a result of the application of Section 409A(a)(2)(B)(i) of the Code, such payment shall not be payable and such benefit shall
not be provided until the date that is the earlier of (A) six months and one day after your separation from service, or (B) your death.
If any such delayed cash payment is otherwise payable on an installment basis, the first payment shall include a catch-up payment covering
amounts that would otherwise have been paid during the six-month period but for the application of this provision, and the balance of
the installments shall be payable in accordance with their original schedule. Any payment to you under this Agreement that is subject
to Section 409A and that is contingent on a termination of employment is contingent on a “separation from service” within
the meaning of Section 409A. Payments pursuant to this Agreement (or referenced in this Agreement), and each installment thereof,
are intended to constitute separate payments for purposes of Section 1.409A-2(b)(2) of the regulations under Section 409A.
To the extent any nonqualified deferred compensation subject to Section 409A payable to you could be paid in more than one taxable
year depending upon you completing certain employment-related actions, then any such payments will commence or occur in the latest such
taxable year to the extent required to avoid the adverse consequences of Section 409A. Any taxable reimbursement due under the terms
of this Agreement shall be paid no later than December 31 of the year after the year in which the expense is incurred, and all taxable
reimbursements and in-kind benefits shall be provided in accordance with Section 1.409A-3(i)(1)(iv) of the regulations
under Section 409A.
In no event whatsoever shall
the Company be liable for any tax, interest or penalties that may be imposed on you by Code Section 409A or pursuant to any other federal
or state tax law or regulation. You are solely and exclusively responsible for payment of all taxes that may be due to federal and state
tax authorities.
22. Entire
Agreement. This Agreement, together with the agreements expressly incorporated herein, constitute the entire agreement between you
and the Company and forms the complete, final, and exclusive embodiment of our agreement with regard to the subject matters covered. It
is entered into without reliance on any promise or representation other than those expressly contained herein, and it supersedes and replaces
any prior agreements, representations or understandings, whether written, oral or implied, between you and the Company. It cannot be modified
or amended except in a writing signed by you and the Chairman of the Board.
We hope that you will accept
our offer to continue your employment with the Company.
Please indicate your acceptance
of this offer by signing both copies of this Agreement and returning one original to me. The other original of the Agreement is for your
files. Please also sign the two copies of the Proprietary Information and Inventions Assignment Agreement and return one with the Agreement.
I await a positive response.
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Very truly yours, |
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CERo Therapeutics Holdings, Inc. |
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By: |
/s/ Brian G. Atwood |
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Name: |
Brian G. Atwood |
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Title: |
Chairman and Chief Executive Officer |
I have read, and accept and
agree to, this letter agreement:
/s/ Daniel Corey |
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Daniel Corey |
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March 28, 2024
Exhibit 19.1
CERO
THERAPEUTICS HOLDINGS, INC.
Insider
Trading POLICY
CERo
Therapeutics Holdings, Inc. (the “Company”) has adopted the following policy and procedures for securities trading
by Company directors and employees (our “Insider Trading Policy”). Our Insider Trading Policy is intended to prevent
the misuse of material nonpublic information, insider trading in securities, and the severe consequences associated with violations of
insider trading laws. It is your obligation to review, understand, and comply with this Insider Trading Policy and applicable laws. Our
Board of Directors has approved this Insider Trading Policy, and we have appointed the Chief Executive Officer, or such other officer
as the Chief Executive Officer may designate from time to time, as the Compliance Officer (with their designees, the “Compliance
Officer”) to administer the policy and to be available to answer your questions.
PART
I. OVERVIEW
A. Who
Must Comply?
This
Insider Trading Policy applies to all of our employees and members of our Board of Directors, including anyone employed by or acting
as a director of any of the Company’s subsidiaries, as well as any other individuals whom the Compliance Officer may designate
as Insiders (defined below) because they have access to material nonpublic information about the Company.
In
addition, all of our directors, executive officers (as defined by Section 16 of the Securities Exchange Act of 1934, as amended (the
“Exchange Act”)) and other designated employees must comply with the Trading Procedures included in Part II of this
Insider Trading Policy (the “Trading Procedures”); we will refer to these individuals in this policy as “Insiders.”
The Trading Procedures provide rules for when Insiders can trade in our securities and explain the process for mandatory pre-clearance
of proposed trades. You will be notified if you are considered to be an Insider who is required to comply with the Trading Procedures.
This
Insider Trading Policy and, for Insiders, the Trading Procedures also apply to the following persons (“Affiliated Persons”):
| ● | your
“Family Members” (“Family Members” are (a) your spouse or
domestic partner, children, stepchildren, grandchildren, parents, stepparents, grandparents,
siblings and in-laws who reside in the same household as you, (b) your children or your spouse’s
children who do not reside in the same household as you but are financially dependent on
you, (c) any of your other family members who do not reside in your household but whose transactions
are directed by you, and (d) any other individual over whose account you have control and
to whose financial support you materially contribute. (Materially contributing to financial
support would include, for example, paying an individual’s rent but not just a phone
bill.).); |
| ● | all
trusts, family partnerships and other types of entities formed for your benefit or for the
benefit of a member of your family and over which you have the ability to influence or direct
investment decisions concerning securities; |
| ● | all
persons who execute trades on your behalf; and |
| ● | all
investment funds, trusts, retirement plans, partnerships, corporations and other types of
entities over which you have the ability to influence or direct investment decisions concerning
securities; provided, however, that the Trading Procedures do not apply to
any such entity that engages in the investment of securities in the ordinary course of its
business (e.g., an investment fund or partnership) if the entity has established its own
insider trading controls and procedures in compliance with applicable securities laws and
it (or an affiliated entity) has represented to the Company that its affiliated entities:
(a) engage in the investment of securities in the ordinary course of their respective businesses;
(b) have established insider trading controls and procedures in compliance with securities
laws; and (c) are aware the securities laws prohibit any person or entity who has material
nonpublic information concerning the Company from purchasing or selling securities of the
Company or from communicating such information to any other person under circumstances in
which it is reasonably foreseeable that such person is likely to purchase or sell securities. |
You
are responsible for ensuring compliance with this Insider Trading Policy, including the Trading Procedures contained herein, by all of
your Affiliated Persons.
B. What
is Prohibited by this Insider Trading Policy?
You
and your Affiliated Persons are prohibited from engaging in insider trading and from trading in securities in violation of this Insider
Trading Policy. “Insider trading” is (1) trading (buying or selling) the securities of a company whether for your account
or for the account of another, while in the possession of material nonpublic information (see definition below) about that company or
(2) disclosing material nonpublic information about a company to others who may trade on the basis of that information. Insider trading
can result in criminal prosecution, jail time, significant fines and public embarrassment for you and the Company.
Prohibition
on Trading in Company Securities
When
you are in possession of material nonpublic information about the Company, whether positive or negative, you are prohibited from trading
(whether for your account of for the account of another) in the Company’s securities, which include common stock, options to purchase
common stock, any other type of securities that the Company may issue (such as preferred stock, convertible debentures, warrants and
exchange-traded options), and any derivative securities that provide the economic equivalent of ownership of any the Company’s
securities or an opportunity, direct or indirect, to profit from any change in the value of the Company’s securities, except for
trades made pursuant to plans approved by the Compliance Officer in accordance with this policy that are intended to comply with Rule
10b5-1 under the Exchange Act.
The
trading prohibitions in this Insider Trading Policy do not apply to: (1) an exercise of an employee stock option when payment
of the exercise price is made in cash or (2) the withholding by the Company of shares of stock upon vesting of restricted stock or upon
settlement of restricted stock units to satisfy applicable tax withholding requirements if (a) such withholding is required by the applicable
plan or award agreement or (b) the election to exercise such tax withholding right was made by the Insider in compliance with the Trading
Procedures.
The
trading prohibitions in this Insider Trading Policy do apply, however, to the use of outstanding Company securities to pay part
or all of the exercise price of a stock option, any sale of stock as part of a broker-assisted cashless exercise of an option, and any
other market sale for the purpose of generating the cash needed to pay the exercise price of an option.
Prohibition
on Tipping
Providing
material nonpublic information about the Company to another person who may trade or advise others to trade on the basis of that information
is known as “tipping” and is illegal. You are prohibited from providing material nonpublic information about the Company
to a friend, relative, or anyone else who might buy or sell a security or other financial instrument on the basis of that information,
whether or not you intend to or actually do realize a profit (or any other benefit) from such tipping. Additionally, you are prohibited
from recommending to any person that such person engage in or refrain from engaging in any transaction involving the Company’s
securities, or otherwise give trading advice concerning the Company’s securities, if you are in possession of material nonpublic
information about the Company.
Prohibition
on Trading in Securities of Other Companies
This
policy’s prohibitions against insider trading and tipping also apply to trading in securities of other companies, including the
Company’s customers, suppliers, partners and other enterprises with which we are working (such as when negotiating an acquisition,
investment or other transaction that could be material to the other company). Whenever, during the course of your service to or employment
by the Company, you become aware of material nonpublic information about another company, including any confidential information that
is reasonably likely to affect the market price of that company’s securities (for example, discussions of licensing a product or
acquiring that other company), neither you nor your Affiliated Persons may trade in any securities of that company, give trading advice
about that company, tip or disclose that information, pass it on to others, or engage in any other action to take advantage of that information.
If
your work regularly involves handling or discussing confidential information of one of our partners, suppliers or customers, you should
consult with the Compliance Officer before trading in any of that company’s securities.
Duration
of Trading Prohibitions
These
trading prohibitions continue whenever and for as long as you know or are in possession of material nonpublic information. Remember,
anyone scrutinizing your transactions will be doing so after the fact, with the benefit of hindsight. As a practical matter, before engaging
in any transaction, you should carefully consider even the appearance of improper insider trading and how enforcement authorities and
others might view the transaction in hindsight.
This
Insider Trading Policy applies to you and your Affiliated Persons so long as you are associated with the Company. If you leave the Company
for any reason, this Insider Trading Policy, including, if applicable, the Trading Procedures described in Part III, will continue to
apply to you and your Affiliated Persons until the later of: (1) the first trading day following the public release of earnings for the
fiscal quarter in which you leave the Company or (2) the first trading day after any material nonpublic information known to you has
become public or is no longer material.
C. What
is Material Nonpublic Information?
This
Insider Trading Policy prohibits you from trading in a company’s securities if you are in possession of information about the company
that is both “material” and “nonpublic.” If you have a question whether certain information you
are aware of is material or has been made public, you should consult with the Compliance Officer.
“Material”
Information
Information
about our Company or any other company is “material” if it could reasonably be expected to affect the investment decisions
of a stockholder or potential investor or if disclosure of the information could reasonably be expected to significantly alter the total
mix of information in the marketplace about us or any other company. We speak mostly in this Insider Trading Policy about determining
whether information about us is material and nonpublic, but the same analysis applies to information about other companies that would
preclude you from trading in their securities.
In
simple terms, material information is any type of information that could reasonably be expected to affect the market price of our securities.
Both positive and negative information may be material. While it is not possible to identify all information that would be deemed “material,”
the following items are examples of the types of information that could be material:
| ● | significant
new scientific discoveries or other events, late-stage preclinical development achievements
or failures from any lead or other important preclinical programs, clinical program developments,
filing of an Investigational New Drug Application or other significant regulatory events
or interactions, relevant regulatory changes, data that have been recently generated from
ongoing or recently completed clinical trials; |
| ● | plans
to pursue, entry into, or termination of a major licensing, partnership, collaboration, manufacturing
or supply agreement, or changes in relationships, including significant disputes, with major
licensors, licensees, partners, collaborators, manufacturers, or suppliers; |
| ● | projections
of future earnings or losses, or other earnings guidance; |
| ● | quarterly
financial results that are known but have not been publicly disclosed; |
| ● | potential
restatements of the Company’s financial statements, changes in auditors or auditor
notification that the Company may no longer rely on an auditor’s audit report; |
| ● | pending
or proposed corporate mergers, acquisitions, tender offers, joint ventures or dispositions
of significant assets; |
| ● | changes
in senior management, significant employees, or member of our Board of Directors; |
| ● | significant
actual or threatened litigation or governmental investigations or major developments in such
matters; |
| ● | cybersecurity
risks and incidents, including the discovery of significant vulnerabilities or breaches; |
| ● | significant
developments regarding products, customers, suppliers, orders, contracts or financing sources
(e.g., the acquisition or loss of a contract); |
| ● | changes
in dividend policy, declarations of stock splits, or proposed securities offerings or other
financings; |
| ● | potential
defaults under our credit agreements or indentures or potential material liquidity issues;
and |
| ● | bankruptcies
or receiverships. |
The
above items will not always be material. For example, some new products or contracts may clearly be material while others may not be.
No “bright-line” standard or list of items can adequately address the range of situations that may arise; information and
events should be carefully considered in terms of their materiality to the Company.
“Nonpublic”
Information
Material
information is “nonpublic” if it has not been disseminated in a manner making it available to investors generally.
To
demonstrate that information is public, one must be able to point to some fact that establishes that the information has become publicly
available, such as the filing of a report with the SEC, the distribution of a press release, publishing the information on our website
or posting on social media if those are regular ways we communicate with investors, or by other means that are reasonably designed to
provide broad public access. Before a person with material nonpublic information can trade, the market must have adequate time to absorb
the information that has been disclosed. For the purposes of this Insider Trading Policy, information will be considered public after
the completion of one full day of trading following our public release of the information. For that purpose, a full day of trading means
an entire calendar day in which a session of regular trading hours on the Nasdaq Stock Market (“Nasdaq”) between 9:30 a.m.
and 4:00 p.m. Eastern Time (or such earlier close time as has been set by exchange rules) has occurred.
For
example, if the Company publicly discloses material nonpublic information of which you are aware before trading begins on a Tuesday,
the first time you can buy or sell Company securities is the opening of the market on Wednesday. However, if the Company publicly discloses
material information after trading begins on a Tuesday, the first time that you can buy or sell Company securities is the opening of
the market on Thursday.
D. What are the Penalties for Insider Trading and Noncompliance with this Insider Trading Policy?
Both
the U.S. Securities and Exchange Commission (the “SEC”) and the national securities exchanges, through the Financial
Industry Regulatory Authority (“FINRA”), investigate and are very effective at detecting insider trading. The U.S.
government pursues insider trading violations vigorously, successfully prosecuting, for example, trading by employees in foreign accounts,
trading by family members and friends of insiders, and trading involving only a small number of shares.
The
penalties for violating rules against insider trading can be severe and include:
| ● | forfeiting
any profit gained or loss avoided by the trading; |
| ● | payment
of the loss suffered by the persons who, contemporaneously with the purchase or sale of securities
that are subject of a violation, have purchased or sold securities of the same class; |
| ● | payment
of criminal penalties of up to $5,000,000; |
| ● | payment
of civil penalties of up to three times the profit made or loss avoided; and |
| ● | imprisonment
for up to 20 years. |
The
Company and/or the supervisors of the person engaged in insider trading may also be required to pay civil penalties or fines of $2 million
or more, up to three times the profit made or loss avoided, as well as criminal penalties of up to $25,000,000, and could under some
circumstances be subject to private lawsuits.
Violation
of this Insider Trading Policy or any federal or state insider trading laws may subject you to disciplinary action by the Company, including
termination of your employment or other relationship with the Company. The Company reserves the right to determine, in its own discretion
and on the basis of the information available to it, whether this Insider Trading Policy has been violated. The Company may determine
that specific conduct violates this Insider Trading Policy whether or not it also violates the law. It is not necessary for the Company
to await the filing or conclusion of a civil or criminal action against an alleged violator before taking disciplinary action.
E. How
Do You Report a Violation of this Insider Trading Policy?
If
you have a question about this Insider Trading Policy, including whether certain information you are aware of is material or has been
made public, you should consult with the Compliance Officer. In addition, if you violate this Insider Trading Policy or any federal or
state laws governing insider trading or know of any such violation by any director or employee of the Company, you should report the
violation immediately to the Compliance Officer.
PART
II. TRADING PROCEDURES
A. Special
Trading Restrictions Applicable to Insiders
In
addition to needing to comply with the restrictions on trading in our securities set forth above, Insiders and their Affiliated Persons
are subject to the following special trading restrictions:
1. Special
Closed Trading Periods
The
Compliance Officer may designate, from time to time, a “Special Closed Window” during what would be a permitted trading window.
During a Special Closed Window, designated Insiders (which could be all Insiders or a subset of them) may not trade in the Company’s
securities. The Compliance Officer may also impose a Special Closed Window on Insiders or a subset of them to prohibit trading in the
securities of other companies, including specified peers or competitors of the Company. The imposition of a Special Closed Window will
not be announced to the Company generally, should not be communicated to any other person, and may itself be considered under this Insider
Trading Policy to be material nonpublic information about the Company.
2. Prohibited
Transactions
| ● | No
Short Sales. You may not at any time sell any securities
of the Company that are not owned by you at the time of the sale (a “short sale”).
|
| ● | No
Purchases or Sales of Derivative Securities or Hedging Transactions. You
may not buy or sell puts, calls, other derivative securities of the Company or any derivative
securities that provide the economic equivalent of ownership of any of the Company’s
securities or an opportunity, direct or indirect, to profit from any change in the value
of our securities or engage in any other hedging transaction with respect to our securities. |
| ● | No
Company Securities Subject to Margin Calls. You may
not use the Company’s securities as collateral in a margin account. |
| ● | No
Pledges. You may not pledge Company securities as collateral
for a loan (or modify an existing pledge). |
3. Gifts
and Other Distributions in Kind.
No
Insider may donate or make any other transfer of Company securities without consideration when the Insider is not permitted to trade
unless the donee agrees not to sell the shares until the Insider is permitted to sell. In addition to charitable donations or gifts to
family members, friends, trusts or others, this prohibition applies to distributions to limited partners by limited partnerships that
are subject to this Insider Trading Policy.
B.
Pre-Clearance Procedures
No
Insider may trade in our securities, even during an open trading window, unless the trade has been approved by the Compliance Officer
in accordance with the procedures described below. Gifts of Company securities are considered a trade in securities for purposes of this
Part II.B. In reviewing trading requests, the Compliance Officer may consult with our other officers and/or outside legal counsel, and
must consult with outside legal counsel and seek approval of their own trades from the Chief Executive Officer.
| 1. | Procedures.
No Insider may trade in our securities unless: |
| ● | The
Insider has notified the Compliance Officer of the amount and nature of the proposed trade(s)
using the Stock Transaction Request form attached to this Insider Trading Policy. To provide
adequate time for the preparation of any required reports under Section 16 of the Exchange
Act, a Stock Transaction Request form should, if practicable, be received by the Compliance
Officer at least two (2) business days before the intended trade date; |
| ● | The
Insider has certified to the Compliance Officer in writing before the proposed trade(s) that
the Insider does not possess material nonpublic information concerning the Company; |
| ● | If
the Insider is an executive officer or director, the Insider has informed the Compliance
Officer, using the Stock Transaction Request form, whether, to the Insider’s best knowledge,
(a) the Insider has (or is deemed to have) engaged in any opposite way transactions within
the previous six months that were not exempt from Section 16(b) of the Exchange Act and (b)
if the transaction involves a sale by an “affiliate” of the Company or of “restricted
securities” (as such terms are defined under Rule 144 under the Securities Act of 1933,
as amended (“Rule 144”)), whether the transaction meets all of the applicable
conditions of Rule 144; and |
| ● | The
Compliance Officer has approved the trade(s) and has certified their approval in writing
(which may be by email). |
The
Compliance Officer does not assume responsibility for, and approval by the Compliance Officer does not protect the Insider from, the
consequences of prohibited insider trading.
| 2. | Additional
Information. |
Insiders
shall provide to the Compliance Officer any documentation the Compliance Officer reasonably requires in furtherance of the foregoing
procedures. Any failure to provide such information will be grounds for the Compliance Officer to deny approval of the trade request.
| 3. | Notification
of Brokers of Insider Status |
Insiders
who are required to file reports under Section 16 of the Exchange Act shall inform their broker-dealers that (a) the Insider is subject
to Section 16; (b) the broker shall confirm that any trade by the Insider or any of their affiliates has been precleared by the Company;
and (c) the broker is to provide transaction information to the Insider and/or Compliance Officer on the day of a trade.
| 4. | No
Obligation to Approve Trades. |
The
foregoing approval procedures do not in any way obligate the Compliance Officer to approve any trade. The Compliance Officer has sole
discretion to reject any trading request.
From
time to time, an event may occur that is material to the Company and is known by only by a limited number of directors and employees.
The Compliance Officer may decline an Insider’s request to preclear a proposed trade based on the existence of a material nonpublic
development – even if the Insider is not aware of that material nonpublic development. If any Insider engages in a trade before
a material nonpublic development is disclosed to the public or resolved, the Insider and the Company might be exposed to a charge of
insider trading that could be costly and difficult to refute even if the Insider was unaware of the development. So long as the event
remains material and nonpublic, the Compliance Officer may decide not to approve any transactions in the Company’s securities.
The Compliance Officer will subsequently notify the Insider once the material nonpublic development is disclosed to the public or resolved.
If an Insider requests preclearance of a trade during the pendency of such an event, the Compliance Officer may reject the trading request
without disclosing the reason.
After
receiving written clearance to engage in a trade signed by the Compliance Officer, an Insider must complete the proposed trade within
three (3) business days or make a new trading request. Even if an Insider has received clearance, the Insider may not engage in a trade
if (i) such clearance has been rescinded by the Compliance Officer, (ii) the Insider has otherwise received notice that the trading window
has closed or (iii) the Insider has or acquires material nonpublic information.
The
details of any transactions in our securities (including transactions effected pursuant to a Rule 10b5-1 Plan) by an Insider (or an Affiliated
Person) who is required to file reports under Section 16 of the Exchange Act must be reported to the Compliance Officer by the Insider
or their brokerage firm on the same day on which a trade order is placed or such a transaction otherwise is entered into. The report
shall include the date of the transaction, quantity of shares, the price and the name of the broker-dealer that effected the transaction.
This reporting requirement may be satisfied by providing (or having the Insider’s broker provide) a trade order confirmation to
the Compliance Officer if the Compliance Officer receives such information by the required date. Compliance by directors and executive
officers with this provision is imperative given the requirement of Section 16 of the Exchange Act that these persons generally report
changes in ownership of Company securities within two (2) business days. The sanctions for noncompliance with this reporting deadline
include mandatory disclosure in the Company’s proxy statement for the next annual meeting of stockholders, as well as possible
civil or criminal sanctions for chronic or egregious violators.
C. Exemptions
| 1. | Pre-Approved
Rule 10b5-1 Plan. |
Transactions
made pursuant to an approved Rule 10b5-1 Plan (as defined below) will not be subject to our trading windows or pre-clearance procedures,
and Insiders are not required to complete a Stock Transaction Request form for such transactions. Rule 10b5-1 of the Exchange Act provides
an affirmative defense from insider trading liability under the federal securities laws for trading plans, arrangements or instructions
that meet specified requirements. A trading plan, arrangement or instruction that meets the requirements of the SEC’s Rule 10b5-1
(a “Rule 10b5-1 Plan”) enables Insiders to trade in Company securities outside of our trading windows, even when in possession
of material nonpublic information.
The
Company has adopted a separate Rule 10b5-1 Trading Plan Policy that sets forth the requirements for putting in place a Rule 10b5-1 Plan
with respect to Company securities.
| 2. | Employee
Equity and Retirement Plans. |
Exercise
of Stock Options. The trading prohibitions and restrictions set forth in the Trading Procedures
do not apply to the exercise for cash of an option to purchase securities of the Company. However, the exercise is subject to the current
reporting requirements of Section 16 of the Exchange Act and, therefore, Insiders must comply with the post-trade reporting requirement
described in Section C above for any such transaction. In addition, the securities acquired upon the exercise of an option to purchase
Company securities are subject to all of the requirements of this Insider Trading Policy, including the Trading Procedures. Moreover,
the Trading Procedures apply to the use of outstanding Company securities to pay part or all of the exercise price of an option, any
net option exercise, any exercise of a stock appreciation right, share withholding and any sale of stock as part of a broker-assisted
cashless exercise of an option or any other market sale for the purpose of generating the cash needed to pay the exercise price of an
option.
Tax
Withholding on Restricted Stock/Units. The trading prohibitions and restrictions set forth in the
Trading Procedures do not apply to the withholding by the Company of shares of stock upon vesting of restricted stock or upon settlement
of restricted stock units to satisfy tax withholding requirements if (a) withholding is required by the applicable plan or award agreement
or (b) the election to exercise the tax withholding right was made by the Insider in compliance with the Trading Procedures.
Employee
Stock Purchase Plan. The trading prohibitions and restrictions set forth in the Trading Procedures
do not apply to periodic wage withholding contributions by the Company or its employees that are used to purchase Company stock pursuant
to the employees’ advance instructions under the Company’s 2024 Employee Stock Purchase Plan. However, an Insider may not:
(a) elect to participate in the plan or alter their instructions regarding the level of withholding or purchase by the Insider of Company
securities under the plan; or (b) make cash contributions to the plan (other than through periodic wage withholding) without complying
with the Trading Procedures. Any sale of securities acquired under the plan is subject to the prohibitions and restrictions of the Trading
Procedures.
D. Waivers
A
waiver of any provision of this Insider Trading Policy or the Trading Procedures may be authorized in writing by the Compliance Officer
or their designee or the Audit Committee of the Board of Directors. All waivers shall be reported to the Board of Directors.
PART
III. AMENDMENT
This
Insider Trading Policy may be amended from time to time with the approval of the Board of Directors or a designated committee thereof.
PART
IV. ACKNOWLEDGEMENT
We
will deliver a copy of this Insider Trading Policy to all current employees and directors and designated consultants and to future employees
and directors and designated consultants at the start of their employment or relationship with the Company. Each of these individuals
must acknowledge that they have received a copy and agree to comply with the terms of this Insider Trading Policy, and, if applicable,
the Trading Procedures contained herein. The attached acknowledgment must be completed and submitted to the Company within ten days of
receipt.
At
our request, directors and employees and designated consultants will be required to re-acknowledge and agree to comply with the Insider
Trading Policy (including any amendments or modifications). For that purpose, an individual will be deemed to have acknowledged and agreed
to comply with the Insider Trading Policy, as amended from time to time, when copies of those items have been delivered by regular or
electronic mail (or other delivery option used by the Company) to the Compliance Officer.
* * *
Questions
regarding this Insider Trading Policy are encouraged and may be directed to the Compliance Officer.
ADOPTED:
February 14, 2024
EFFECTIVE: February
14, 2024
EXHIBIT
A
STOCK
TRANSACTION REQUEST
Pursuant
to CERO THERAPEUTICS HOLDINGS, INC.’s Insider Trading Policy, I hereby notify CERO THERAPEUTICS HOLDINGS INC. (the
“Company”) of my intent to trade the securities of the Company as indicated below:
REQUESTER
INFORMATION
Insider’s
Name: _________________________________________
|
INTENT
TO PURCHASE
Number
of shares: __________________________
Intended
trade date: __________________________ |
Means
of acquiring shares: |
☐ |
Acquisition
through employee benefit plan (please specify):
___________________________________________________________
|
|
☐ |
Purchase
through a broker on the open market
|
|
☐ |
Other
(please specify): ________________________________________ |
INTENT
TO SELL
Number
of shares: __________________________
Intended
trade date: __________________________ |
Means
of selling shares: |
☐ |
Sale
through employee benefit plan (please specify):
___________________________________________________________
|
|
☐ |
Sale
through a broker on the open market
|
|
☐ |
Other
(please specify): ________________________________________ |
SECTION
16 |
|
RULE
144 (Not applicable if transaction
requested involves a purchase) |
☐
|
I
am not subject to Section 16.
|
☐
|
I
am not an “affiliate” of the Company and the transaction requested above does
not involve the sale of “restricted securities” (as those terms are defined in
Rule 144 under the Securities Act of 1933, as amended).
|
|
|
|
|
☐ |
To the
best of my knowledge, I have not (and am not deemed to have) engaged in an opposite way transaction within the previous 6 months
that was not exempt from Section 16(b) of the Exchange Act. |
☐ |
To
the best of my knowledge, the transaction requested above will meet all of the applicable conditions of Rule 144. |
|
|
|
|
☐ |
None of
the above. |
☐ |
The
transaction requested will be made pursuant to an effective registration statement covering such transaction. |
|
|
|
|
|
|
☐ |
None
of the above. |
|
|
|
|
|
|
|
|
CERTIFICATION
I
hereby certify that I am not (1) in possession of any material nonpublic information concerning the Company, as defined in the Company’s
Insider Trading Policy and (2) purchasing any securities of the Company on margin in contravention of the Company’s Trading
Procedures. I understand that, if I trade while possessing such information or in violation of such trading restrictions, I may be
subject to severe civil and/or criminal penalties and may be subject to discipline by the Company including termination of my employment.
|
|
|
Insider’s
Signature |
|
Date |
|
APPROVAL
|
|
Signature
of Compliance Officer (or designee) |
|
Date |
|
|
|
|
|
|
* | NOTE:
Multiple lots must be listed on separate forms or broken out. |
EXHIBIT
B
ACKNOWLEDGEMENT
I
hereby acknowledge that I have read, that I understand, and that I agree to comply with the Insider Trading Policy of CERo Therapeutics
Holdings, Inc. (the “Company”). I further acknowledge and agree that I am responsible for ensuring compliance with the Insider
Trading Policy and the Trading Procedures by all of my “Affiliated Persons.” I also understand and agree that I will be subject
to sanctions, including termination of employment, that may be imposed by the Company, in its sole discretion, for violation of the Insider
Trading Policy, and that the Company may give stop-transfer and other instructions to the Company’s transfer agent or any brokerage
firm managing the Company’s equity incentive plan(s) against the transfer of any Company securities that the Company considers
to be in contravention of the Insider Trading Policy.
This
acknowledgement constitutes consent for the Company to impose sanctions for violation of the Insider Trading Policy, including the Trading
Procedures, and to issue any stop-transfer orders to the Company’s transfer agent that the Company, in its sole discretion, deems
appropriate to ensure compliance.
Date: |
|
|
Signature: |
|
|
|
|
|
Name: |
|
|
|
|
|
Title: |
|
Send
signed Acknowledgement to:
[Name]
[Title]
[Company
Name]
[Address]
14
Exhibit 21.1
Subsidiaries of CERo Therapeutics Holdings,
Inc.
Name of Subsidiary |
|
Jurisdiction of Incorporation |
CERo Therapeutics, Inc. |
|
Delaware |
Exhibit 31.1
CERTIFICATION OF CHIEF EXECUTIVE OFFICER
PURSUANT TO RULE 13A-14(A) UNDER THE SECURITIES
EXCHANGE ACT OF 1934,
AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY
ACT OF 2002
I, Brian G. Atwood, certify that:
| 1. | I have reviewed this annual report on Form 10-K of CERo Therapeutics Holdings, Inc.; |
| 2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary
to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period
covered by this report; |
| 3. | Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material
respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this
report; |
| 4. | The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures
(as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules
13a-15(f) and 15d-15(f)) for the registrant and have: |
| a) | Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision,
to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others
within those entities, particularly during the period in which this report is being prepared; |
| b) | Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions
about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation;
and |
| c) | Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s
most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected,
or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and |
| 5. | The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over
financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons
performing the equivalent functions): |
| a) | All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which
are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information;
and |
| b) | Any
fraud, whether or not material, that involves management or other employees who have a significant
role in the registrant’s internal control over financial reporting. |
Date:
April 2, 2024
|
|
|
/s/
Brian G. Atwood |
|
Brian G. Atwood |
|
Chief Executive Officer |
|
(Principal Executive Officer) |
Exhibit 31.2
CERTIFICATION OF CHIEF FINANCIAL OFFICER
PURSUANT TO RULE 13A-14(A) UNDER THE SECURITIES
EXCHANGE ACT OF 1934,
AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY
ACT OF 2002
I, Charles Carter, certify that:
| 1. | I have reviewed this annual report on Form 10-K of CERo Therapeutics Holdings, Inc.; |
| 2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary
to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period
covered by this report; |
| 3. | Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material
respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this
report; |
| 4. | The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures
(as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules
13a-15(f) and 15d-15(f)) for the registrant and have: |
| a) | Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision,
to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others
within those entities, particularly during the period in which this report is being prepared; |
| b) | Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions
about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation;
and |
| c) | Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s
most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected,
or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and |
| 5. | The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over
financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons
performing the equivalent functions): |
| a) | All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which
are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information;
and |
| b) | Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s
internal control over financial reporting. |
Date: April 2, 2024
|
|
|
/s/ Charles Carter |
|
Charles Carter |
|
Chief Financial Officer |
|
(Principal Financial and Accounting Officer) |
Exhibit 32.1
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Annual Report of CERo Therapeutics
Holdings, Inc. (the “Company”) on Form 10-K for the year ended December 31, 2023, as filed with the Securities and Exchange
Commission (the “Report”), I, Brian G. Atwood, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. §1350,
as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:
| 1. | The Report fully complies with the requirements of Section 13(a)
or 15(d) of the Securities Exchange Act of 1934; and |
| 2. | The information contained in the Report fairly presents,
in all material respects, the financial condition and results of operations of the Company. |
Dated: April 2, 2024
|
/s/ Brian G. Atwood
|
|
Brian G. Atwood |
|
Chief Executive Officer |
|
(Principal Executive Officer) |
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Annual Report of CERo Therapeutics
Holdings, Inc. (the “Company”) on Form 10-K for the year ended December 31, 2023, as filed with the Securities and Exchange
Commission (the “Report”), I, Charles R. Carter, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. §1350,
as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:
| 1. | The Report fully complies with the requirements of Section 13(a)
or 15(d) of the Securities Exchange Act of 1934; and |
| 2. | The information contained in the Report fairly presents,
in all material respects, the financial condition and results of operations of the Company. |
Dated: April 2, 2024
|
/s/ Charles R. Carter
|
|
Charles R. Carter |
|
Chief Financial Officer |
|
(Principal Financial and Accounting Officer) |
Exhibit 97.1
CERO THERAPEUTICS HOLDINGS, INC.
COMPENSATION RECOVERY POLICY
Adopted as of February 14, 2024
CERo Therapeutics Holdings, Inc., a Delaware corporation (the “Company”),
has adopted a Compensation Recovery Policy (this “Policy”) as described below.
1. Overview
The Policy sets forth the circumstances and procedures under which
the Company shall recover Erroneously Awarded Compensation from Covered Persons (as defined below) in accordance with rules issued by
the United States Securities and Exchange Commission (the “SEC”) under the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), and the Nasdaq Stock Market. Capitalized terms used and not otherwise defined herein shall have the meanings
given in Section 3 below.
2. Compensation Recovery
Requirement
In the event the Company is required to prepare a Financial Restatement,
the Company shall recover reasonably promptly all Erroneously Awarded Compensation with respect to such Financial Restatement.
3. Definitions
| a. | “Applicable Recovery Period” means the three completed fiscal years immediately preceding the Restatement Date for a Financial
Restatement. In addition, in the event the Company has changed its fiscal year: (i) any transition period of less than nine months occurring
within or immediately following such three completed fiscal years shall also be part of such Applicable Recovery Period and (ii) any transition
period of nine to 12 months will be deemed to be a completed fiscal year. |
| b. | “Applicable Rules” means any rules or regulations adopted by the Exchange pursuant to Rule 10D-1 under the Exchange Act
and any applicable rules or regulations adopted by the SEC pursuant to Section 10D of the Exchange Act. |
| c. | “Board” means the Board of Directors of the Company. |
| d. | “Committee” means the Compensation Committee of the Board or, in the absence of such committee, a majority of independent
directors serving on the Board. |
| e. | “Covered Person” means any Executive Officer. A person’s status as a Covered Person with respect to Erroneously
Awarded Compensation shall be determined as of the time of receipt of such Erroneously Awarded Compensation regardless of the person’s
current role or status with the Company (e.g., if a person began service as an Executive Officer after the beginning of an Applicable
Recovery Period, that person would not be considered a Covered Person with respect to Erroneously Awarded Compensation received before
the person began service as an Executive Officer, but would be considered a Covered Person with respect to Erroneously Awarded Compensation
received after the person began service as an Executive Officer where such person served as an Executive Officer at any time during the
performance period for such Erroneously Awarded Compensation). |
| f. | “Effective Date” means October 2, 2023. |
| g. | “Erroneously Awarded Compensation” means the amount of any Incentive-Based Compensation received by a Covered Person on
or after the Effective Date and during the Applicable Recovery Period that exceeds the amount that otherwise would have been received
by the Covered Person had such compensation been determined based on the restated amounts in a Financial Restatement, computed without
regard to any taxes paid. Calculation of Erroneously Awarded Compensation with respect to Incentive-Based Compensation based on stock
price or total shareholder return, where the amount of Erroneously Awarded Compensation is not subject to mathematical recalculation directly
from the information in a Financial Restatement, shall be based on a reasonable estimate of the effect of the Financial Restatement on
the stock price or total shareholder return upon which the Incentive-Based Compensation was received, and the Company shall maintain documentation
of the determination of such reasonable estimate and provide such documentation to the Exchange in accordance with the Applicable Rules.
Incentive-Based Compensation is deemed received, earned or vested when the Financial Reporting Measure is attained, not when the actual
payment, grant or vesting occurs. |
| h. | “Exchange” means the Nasdaq Stock Market LLC. |
| i. | An “Executive Officer” means any person who served the Company in any of the following roles at any time during the performance
period applicable to Incentive-Based Compensation and received Incentive-Based Compensation after beginning service in any such role (regardless
of whether such Incentive-Based Compensation was received during or after such person’s service in such role): the president, principal
financial officer, principal accounting officer (or if there is no such accounting officer the controller), any vice president in charge
of a principal business unit, division or function (such as sales, administration or finance), any other officer who performs a policy
making function or any other person who performs similar policy making functions for the Company. Executive officers of parents or subsidiaries
of the Company may be deemed executive officers of the Company if they perform such policy making functions for the Company. |
| j. | “Financial Reporting Measures” mean measures that are determined and presented in accordance with the accounting principles
used in preparing the Company’s financial statements, any measures that are derived wholly or in part from such measures (including,
for example, a non-GAAP financial measure), and stock price and total shareholder return. |
| k. | “Incentive-Based Compensation” means any compensation provided, directly or indirectly, by the Company or any of its subsidiaries
that is granted, earned or vested based, in whole or in part, upon the attainment of a Financial Reporting Measure. For avoidance of doubt,
Incentive-Based Compensation is “received” for purposes of this Policy in fiscal period during which the Financial Reporting
Measure specified in the Incentive-Based Compensation award is attained, even if the payment or grant of such Incentive-Based Compensation
occurs after the end of that period. |
| l. | A “Financial Restatement” means a restatement of previously issued financial statements of the Company due to the material
noncompliance of the Company with any financial reporting requirement under the securities laws, including any required restatement to
correct an error in previously-issued financial statements that is material to the previously-issued financial statements or that would
result in a material misstatement if the error were corrected in the current period or left uncorrected in the current period. |
| m. | “Restatement Date” means, with respect to a Financial Restatement, the earlier to occur of: (i) the date the Board concludes,
or reasonably should have concluded, that the Company is required to prepare the Financial Restatement or (ii) the date a court, regulator
or other legally authorized body directs the Company to prepare the Financial Restatement. |
4. Exception to Compensation
Recovery Requirement
The Company may elect not to recover Erroneously Awarded Compensation
pursuant to this Policy if the Committee determines that recovery would be impracticable, and one or more of the following conditions,
together with any further requirements set forth in the Applicable Rules, are met: (i) the direct expense paid to a third party, including
outside legal counsel, to assist in enforcing this Policy would exceed the amount to be recovered, and the Company has made a reasonable
attempt to recover such Erroneously Awarded Compensation; or (ii) recovery would likely cause an otherwise tax-qualified retirement plan
to fail to be so qualified under applicable regulations.
5. Tax Considerations
To the extent that, pursuant to this Policy, the Company is entitled
to recover any Erroneously Awarded Compensation that is received by a Covered Person, the gross amount received (i.e., the amount the
Covered Person received, or was entitled to receive, before any deductions for tax withholding or other payments) shall be returned by
the Covered Person.
6. Method of Compensation
Recovery
The Committee shall determine, in its sole discretion, the method for
recovering Erroneously Awarded Compensation hereunder, which may include, without limitation, any one or more of the following:
| a. | requiring reimbursement of cash Incentive-Based Compensation previously paid; |
| b. | seeking recovery of any gain realized on the vesting, exercise, settlement, sale, transfer or other disposition of any equity-based
awards; |
| c. | cancelling or rescinding some or all outstanding vested or unvested equity-based awards; |
| d. | adjusting or withholding from unpaid compensation or other set-off; |
| e. | cancelling or offsetting against planned future grants of equity-based awards; and/or |
| f. | any other method permitted by applicable law or contract. |
The Committee need not utilize the same method of recovery from all
Covered Persons or with respect to all types of Erroneously Awarded Compensation.
A Covered Person will be deemed to have satisfied such person’s
obligation to return Erroneously Awarded Compensation to the Company if such Erroneously Awarded Compensation is returned in the exact
same form in which it was received; provided that equity withheld to satisfy tax obligations will be deemed to have been received in cash
in an amount equal to the tax withholding payment made.
In the event the Company is required to recover Erroneously Awarded
Compensation from a Covered Person who is no longer an employee, the Company is entitled to seek such recovery in order to comply with
applicable law, regardless of the terms of any release of claims or separation agreement such individual may have signed.
7. Policy Interpretation
This Policy shall be interpreted in a manner that is consistent with
the Applicable Rules and any other applicable law. The Committee shall take into consideration any applicable interpretations and guidance
of the SEC in interpreting this Policy, including, for example, in determining whether a financial restatement qualifies as a Financial
Restatement hereunder. To the extent the Applicable Rules require recovery of Incentive-Based Compensation in additional circumstances
besides those specified above, nothing in this Policy shall be deemed to limit or restrict the right or obligation of the Company to recover
Incentive-Based Compensation to the fullest extent required by the Applicable Rules.
8. Policy Administration
This Policy shall be administered by the Committee; provided, however,
that the Board shall have exclusive authority to authorize the Company to prepare a Financial Restatement. In doing so, the Board may
rely on a recommendation of the Audit Committee of the Board. The Committee shall have such powers and authorities related to the administration
of this Policy as are consistent with the governing documents of the Company and applicable law. The Committee shall have full power and
authority to take, or direct the taking of, all actions and to make all determinations required or provided for under this Policy and
shall have full power and authority to take, or direct the taking of, all such other actions and make all such other determinations not
inconsistent with the specific terms and provisions of this Policy that the Committee deems to be necessary or appropriate to the administration
of this Policy. The interpretation and construction by the Committee of any provision of this Policy and all determinations made by the
Committee under this policy shall be final, binding and conclusive.
9. Compensation Recovery
Repayments not Subject to Indemnification
Notwithstanding anything to the contrary set forth in any agreement
with, or the organizational documents of, the Company or any of its subsidiaries, Covered Persons are not entitled to indemnification
for Erroneously Awarded Compensation or for any losses arising out of or in any way related to Erroneously Awarded Compensation recovered
under this Policy.
10. No Impairment of Other
Remedies
Nothing contained in this Policy, and no recoupment or recovery as
contemplated herein, shall limit any claims, damages or other legal remedies the Company or any of its affiliates may have against a Covered
Person arising out of or resulting from any actions or omissions by the Covered Person. This Policy does not preclude the Company from
taking any other action to enforce a Covered Person’s obligations to the Company, including, without limitation, termination of
employment and/or institution of civil proceedings. This Policy is in addition to the requirements of Section 304 of the Sarbanes-Oxley
Act of 2002 (“SOX 304”) that are applicable to the Company’s Chief Executive Officer and Chief Financial Officer and
to any other compensation recoupment policy and/or similar provisions in any employment, equity plan, equity award, or other individual
agreement, to which the Company is a party or which the Company has adopted or may adopt and maintain from time to time; provided, however,
that compensation recouped pursuant to this Policy shall not be duplicative of compensation recouped pursuant to SOX 304 or any such compensation
recoupment policy and/or similar provisions in any such employment, equity plan, equity award, or other individual agreement except as
may be required by law.
11. Recovery Requirement
Shall not Constitute “Good Reason” Under Employment or Other Compensation Agreements
Any action by the Company to recoup or any recoupment
of Erroneously Awarded Compensation under this Policy from a Covered Person shall not be deemed (i) “good reason” for such
Covered Person’s resignation or to serve as a basis for a claim of constructive termination under any employment or severance agreement
with the Company or under the terms of any benefits or compensation arrangement applicable to such Covered Person, or (ii) to constitute
a breach of a contract or other arrangement to which such Covered Person is party.
12. Amendment; Termination
The Committee may amend this Policy in its discretion, including as
it deems necessary to comply with the regulations adopted by the SEC under Rule 10D-1 and the rules of any national securities exchange
or national securities association on which the Company’s securities are listed. The Committee may terminate this Policy at any
time. Notwithstanding anything herein to the contrary, no amendment or termination of this Policy shall be effective if that amendment
or termination would cause the Company to violate any federal securities laws, SEC rules or the rules of any national securities exchange
or national securities association on which the Company’s securities are listed.
13. Successors
This Policy shall be binding and enforceable against all Covered Executives
and their successors, beneficiaries, heirs, executors, administrators, or other legal representatives.
*
* *
5
v3.24.1
Cover - USD ($)
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12 Months Ended |
|
|
Dec. 31, 2023 |
Apr. 01, 2024 |
Jun. 30, 2023 |
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v3.24.1
Balance Sheets - USD ($)
|
Dec. 31, 2023 |
Dec. 31, 2022 |
CURRENT ASSETS |
|
|
Cash |
$ 96,873
|
$ 475,870
|
Prepaid expenses and other assets |
27,426
|
225,188
|
Money market funds held in Trust Account |
8,436,311
|
|
Restricted cash held in Trust Account |
|
41,665,974
|
TOTAL ASSETS |
8,560,610
|
42,367,032
|
CURRENT LIABILITIES |
|
|
Accounts payable and accrued expenses |
3,535,084
|
1,653,120
|
Income tax payable |
23,633
|
599,159
|
Shareholder redemption liability |
|
27,842,747
|
Excise tax payable |
56,389
|
|
Due to Affiliate |
3,315
|
3,315
|
Total current liabilities |
5,173,421
|
30,748,341
|
LONG TERM LIABILITIES |
|
|
Deferred underwriting fee payable |
9,150,000
|
9,150,000
|
Total liabilities |
14,323,421
|
39,898,341
|
COMMITMENTS AND CONTINGENCIES |
|
|
REDEEMABLE COMMON STOCK |
|
|
Class A Common stock subject to possible redemption, $0.0001 par value, 764,957 and 1,288,298 shares at redemption value of $11.03 and $10.26 per share as of December 31, 2023 and 2022, respectively |
8,436,311
|
13,468,845
|
STOCKHOLDERS’ DEFICIT |
|
|
Preferred stock, $0.0001 par value; 1,000,000 shares authorized; none issued or outstanding |
|
|
Additional paid-in capital |
|
|
Accumulated deficit |
(14,199,669)
|
(11,000,701)
|
Total stockholders’ deficit |
(14,199,122)
|
(11,000,154)
|
TOTAL LIABILITIES, REDEEMABLE COMMON STOCK, AND STOCKHOLDERS’ DEFICIT |
8,560,610
|
42,367,032
|
Class A Common Stock |
|
|
STOCKHOLDERS’ DEFICIT |
|
|
Common stock value |
547
|
88
|
Class B Common Stock |
|
|
STOCKHOLDERS’ DEFICIT |
|
|
Common stock value |
|
459
|
Related Party |
|
|
CURRENT LIABILITIES |
|
|
Working capital loan – related party |
$ 1,555,000
|
$ 650,000
|
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v3.24.1
Balance Sheets (Parentheticals) - $ / shares
|
Dec. 31, 2023 |
Dec. 31, 2022 |
Common stock subject to possible redemption, par value (in Dollars per share) |
$ 0.0001
|
$ 0.0001
|
Common stock subject to possible redemption, shares |
764,957
|
1,288,298
|
Common stock subject to possible redemption value, price per share (in Dollars per share) |
$ 11.03
|
$ 10.26
|
Preferred stock, par value (in Dollars per share) |
$ 0.0001
|
$ 0.0001
|
Preferred stock, shares authorized |
1,000,000
|
1,000,000
|
Preferred stock, shares issued |
|
|
Preferred stock, shares outstanding |
|
|
Class A Common Stock |
|
|
Common stock, par value (in Dollars per share) |
$ 0.0001
|
$ 0.0001
|
Common stock, shares authorized |
60,000,000
|
60,000,000
|
Common stock, shares issued |
5,481,250
|
885,000
|
Common stock, shares outstanding |
5,481,250
|
885,000
|
Class B Common Stock |
|
|
Common stock, par value (in Dollars per share) |
$ 0.0001
|
$ 0.0001
|
Common stock, shares authorized |
10,000,000
|
10,000,000
|
Common stock, shares issued |
0
|
4,596,250
|
Common stock, shares outstanding |
0
|
4,596,250
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.24.1
Statements of Operations - USD ($)
|
12 Months Ended |
Dec. 31, 2023 |
Dec. 31, 2022 |
OPERATING EXPENSES |
|
|
General and administrative |
$ 2,892,935
|
$ 2,841,391
|
Franchise tax |
40,050
|
64,050
|
Loss from operations |
(2,932,985)
|
(2,905,441)
|
Other income: |
|
|
Interest income earned on marketable securities held in Trust Account |
491,571
|
2,836,864
|
Total other income |
491,571
|
2,836,864
|
Loss before provision for income taxes |
(2,441,414)
|
(68,577)
|
Provision for income taxes |
(94,819)
|
(599,159)
|
Net loss |
$ (2,536,233)
|
$ (667,736)
|
Class A Common Stock |
|
|
Other income: |
|
|
Weighted average shares outstanding (in Shares) |
4,224,247
|
17,896,428
|
Basic net loss per share (in Dollars per share) |
$ (0.39)
|
$ (0.03)
|
Class B Common Stock |
|
|
Other income: |
|
|
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|
4,596,250
|
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$ (0.39)
|
$ (0.03)
|
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v3.24.1
Statements of Changes in Stockholders’ Deficit - USD ($)
|
Class A
Common Stock
|
Class B
Common Stock
|
Additional paid-in capital |
Accumulated deficit |
Total |
Balance at Dec. 31, 2021 |
$ 88
|
$ 459
|
|
$ (7,670,412)
|
$ (7,669,865)
|
Balance (in Shares) at Dec. 31, 2021 |
885,000
|
4,596,250
|
|
|
|
Accretion for Class A Common Stock Subject to Redemption |
|
|
|
(2,662,553)
|
(2,662,553)
|
Net income (loss) |
|
|
|
(667,736)
|
(667,736)
|
Balance at Dec. 31, 2022 |
$ 88
|
$ 459
|
|
(11,000,701)
|
(11,000,154)
|
Balance (in Shares) at Dec. 31, 2022 |
885,000
|
4,596,250
|
|
|
|
Accretion for Class A Common Stock Subject to Redemption |
|
|
|
(606,346)
|
(606,346)
|
Excise tax liability accrued for Class A common stock redemptions |
|
|
|
(56,389)
|
(56,389)
|
Conversion of Class B common stock to Class A common stock |
$ 459
|
$ (459)
|
|
|
|
Conversion of Class B common stock to Class A common stock (in Shares) |
4,596,250
|
(4,596,250)
|
|
|
|
Net income (loss) |
|
|
|
(2,536,233)
|
(2,536,233)
|
Balance at Dec. 31, 2023 |
$ 547
|
|
|
$ (14,199,669)
|
$ (14,199,122)
|
Balance (in Shares) at Dec. 31, 2023 |
5,481,250
|
|
|
|
|
X |
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v3.24.1
Statements of Cash Flows - USD ($)
|
12 Months Ended |
Dec. 31, 2023 |
Dec. 31, 2022 |
CASH FLOWS FROM OPERATING ACTIVITIES |
|
|
Net loss |
$ (2,536,233)
|
$ (667,736)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Interest income earned on marketable securities held in Trust Account |
(491,571)
|
(2,836,864)
|
Changes in operating assets and liabilities: |
|
|
Prepaid expenses and other assets |
197,762
|
254,831
|
Income tax payable |
(575,526)
|
599,159
|
Accounts payable and accrued expenses |
1,881,964
|
1,638,687
|
Franchise tax payable |
|
(80,324)
|
Net cash used in operating activities |
(1,523,604)
|
(1,092,247)
|
CASH FLOWS FROM INVESTING ACTIVITIES |
|
|
Cash withdrawn from Trust Account for taxes |
752,300
|
144,544
|
Investment of restricted cash into marketable securities in the Trust Account |
(14,335,919)
|
(325,000)
|
Cash withdrawn from Trust Account in connection with Class A common stock redemption |
5,638,879
|
181,019,852
|
Net cash provided by investing activities |
(7,944,740)
|
180,839,396
|
CASH FLOWS FROM FINANCING ACTIVITIES: |
|
|
Proceeds from promissory note - related party |
905,000
|
650,000
|
Redemption of Class A common stock |
(33,481,627)
|
(139,353,878)
|
Net cash used in financing activities |
(32,576,627)
|
(138,703,878)
|
NET CHANGE IN CASH AND RESTRICTED CASH |
(42,044,971)
|
41,043,271
|
CASH AND RESTRICTED CASH, BEGINNING OF PERIOD |
42,141,844
|
1,098,573
|
CASH AND RESTRICTED CASH, END OF PERIOD |
96,873
|
42,141,844
|
Supplemental cash flow information: |
|
|
Cash paid for income taxes |
670,345
|
|
Supplemental disclosure of noncash activities: |
|
|
Accretion of Class A common stock subject to possible redemption |
606,346
|
2,662,553
|
Shareholder redemption liability |
|
27,842,747
|
Conversion of Class B common to Class A common |
(459)
|
|
Excise tax liability accrued for Class A common stock redemptions |
$ 56,389
|
|
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v3.24.1
Description of Organization and Business Operations and Liquidity
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12 Months Ended |
Dec. 31, 2023 |
Description of Organization and Business Operations and Liquidity [Abstract] |
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Description of Organization and Business Operations and Liquidity |
Note
1 — Description of Organization and Business Operations and Liquidity
Phoenix
Biotech Acquisition Corp. (the “Company”) was incorporated in Delaware on June 8, 2021. The Company was formed for the purpose
of effecting a merger, capital stock exchange, asset acquisition, stock purchase, reorganization, or similar business combination with
one or more businesses (a “business combination”).
The
Company is not limited to a particular industry or geographic region for purposes of consummating a business combination. The Company
is an early stage and emerging growth company and, as such, the Company is subject to all of the risks associated with early stage and
emerging growth companies.
As
of December 31, 2023, the Company had not commenced any operations. All activity through December 31, 2023 relates to the Company’s
formation and initial public offering (“IPO”), which is described below and, since the offering, the search for a prospective
initial business combination. The Company will not generate any operating revenues until after the completion of its initial business
combination, at the earliest. The Company generates non-operating income in the form of interest income earned on investments from the
proceeds derived from the IPO and placed in the Trust Account (defined below). The registration statement for the Company’s IPO
was declared effective on October 5, 2021. On October 8, 2021, the Company consummated the IPO of 15,500,000 units (“Units”)
(with respect to the Class A common stock included in the Units being offered (the “Public Shares”)) at $10.00 per Unit generating
gross proceeds of $155,000,000, which is discussed in Note 3. The Company has selected December 31 as its fiscal year end.
Simultaneously
with the closing of the IPO, the Company consummated the sale of 845,000 units (“Private Placement Units”) (with respect
to the Class A common stock included in the Private Placement Units offered, the “Private Placement Shares”) at a price
of $10.00 per Private Placement Unit in a private placement to the Company’s sponsor, Phoenix Biotech Sponsor, LLC (the
“Sponsor”), Cantor Fitzgerald & Co. (“Cantor”) and Cohen & Company Capital Markets, a division of
J.V.B. Financial Group, LLC (“CCM”), generating gross proceeds of $8,450,000, which is described in Note 4.
Simultaneously
with the closing of the IPO, the Company consummated the sale of 2,000,000 additional Units upon receiving notice of the underwriter’s
election to partially exercise its overallotment option (“Overallotment Units”), generating additional gross proceeds of
$20,000,000 and incurring additional offering costs of $1,400,000 in underwriting fees, all of which are deferred until the completion
of the Company’s initial business combination. Simultaneously with the exercise of the overallotment, the Company consummated the
Private Placement of an additional 40,000 Private Placement Units to the Sponsor and CCM, generating gross proceeds of $400,000.
Offering
costs for the IPO and exercise of the overallotment option amounted to $12,729,318, consisting of $2,635,000 of underwriting fees, $9,150,000
of deferred underwriting fees payable (which are held in the Trust Account (defined below)) and $944,318 of other costs. As described
in Note 6, the $9,150,000 of deferred underwriting fees payable is contingent upon the consummation of a business combination by January
8, 2024, subject to the terms of the underwriting agreement.
Following
the closing of the IPO, $178,500,000 ($10.20 per Unit) from the net proceeds of the sale of the Units in the IPO, the Overallotment Units
and the Private Placement Units was placed in a trust account (“Trust Account”) and invested in U.S. government securities,
within the meaning set forth in Section 2(a)(16) of the Investment Company Act of 1940, as amended (the “Investment Company Act”),
with a maturity of 185 days or less or in money market funds meeting the conditions of the Investment Company Act, as determined by the
Company, until the earlier of: (i) the completion of a business combination and (ii) the distribution of the Trust Account, as described
below.
The
Company’s management has broad discretion with respect to the specific application of the net proceeds of the IPO and the sale
of the Private Placement Units, although substantially all of the net proceeds are intended to be applied generally toward consummating
a business combination. There is no assurance that the Company will be able to complete a business combination successfully. The Company
must complete one or more initial business combinations having an aggregate fair market value of at least 80% of the assets held in the
Trust Account (excluding the deferred underwriting commissions and taxes payable on income earned on the Trust Account) at the time of
the agreement to enter into the initial business combination. However, the Company will only complete a business combination if the post-transaction
company owns or acquires 50% or more of the outstanding voting securities of the target or otherwise acquires a controlling interest
in the target sufficient for it not to be required to register as an investment company under the Investment Company Act. There is no
assurance the Company will be able to successfully effect a business combination.
The
Company will provide the holders of the outstanding Public Shares (the “Public Stockholders”) with the opportunity to redeem
all or a portion of their Public Shares upon the completion of a business combination either (i) in connection with a stockholder meeting
called to approve the business combination or (ii) by means of a tender offer. The decision as to whether the Company will seek stockholder
approval of a business combination or conduct a tender offer will be made by the Company. The Public Stockholders will be entitled to
redeem their Public Shares for a pro rata portion of the amount then in the Trust Account (initially $10.20 per Public Share, plus any
pro rata interest then in the Trust Account, net of taxes payable). There will be no redemption rights with respect to the Company’s
warrants. All
of the Public Shares contain a redemption feature which allows for the redemption of such Public Shares in connection with the Company’s
liquidation, if there is a stockholder vote or tender offer in connection with the Company’s business combination and in connection
with certain amendments to the Company’s amended and restated certificate of incorporation (the “Charter”). In accordance
with the rules of the U.S. Securities and Exchange Commission (the “SEC”) and its guidance on redeemable equity instruments,
which has been codified in Accounting Standards Codification (“ASC”) 480-10-S99, redemption provisions not solely within
the control of a company require common stock subject to redemption to be classified outside of permanent equity. Given that the Public
Shares were issued with other freestanding instruments (i.e., public warrants), the initial carrying value of Class A common stock classified
as temporary equity will be the allocated proceeds determined in accordance with ASC 470-20. The Class A common stock is subject to ASC
480-10-S99. If it is probable that the equity instrument will become redeemable, the Company has the option to either (i) accrete changes
in the redemption value over the period from the date of issuance (or from the date that it becomes probable that the instrument will
become redeemable, if later) to the earliest redemption date of the instrument or (ii) recognize changes in the redemption value immediately
as they occur and adjust the carrying amount of the instrument to equal the redemption value at the end of each reporting period. The
Company has elected to recognize the changes immediately. The accretion or remeasurement will be treated as a deemed dividend (i.e.,
a reduction to retained earnings, or in the absence of retained earnings, additional paid-in capital). While redemptions cannot cause
the Company’s net tangible assets to fall below $5,000,001, the Public Shares are redeemable and are classified as such on the
balance sheet until such date that a redemption event takes place.
Redemptions
of the Company’s Public Shares may be subject to the satisfaction of conditions, including minimum cash conditions, pursuant to
an agreement relating to a business combination. If the Company seeks stockholder approval of the business combination, the Company will
proceed with a business combination if a majority of the shares voted are voted in favor of the business combination, or such other vote
as required by law or stock exchange rule. If a stockholder vote is not required by applicable law or stock exchange listing requirements
and the Company does not decide to hold a stockholder vote for business or other reasons, the Company will, pursuant to its Charter,
conduct the redemptions pursuant to the tender offer rules of the SEC and file tender offer documents with the SEC prior to completing
a business combination. If, however, stockholder approval of the transaction is required by applicable law or stock exchange listing
requirements, or the Company decides to obtain stockholder approval for business or other reasons, the Company will offer to redeem shares
in conjunction with a proxy solicitation pursuant to the proxy rules and not pursuant to the tender offer rules. If the Company seeks
stockholder approval in connection with a business combination, the Sponsor has agreed to vote its Founder Shares (as defined in Note
5), Private Placement Shares and any Public Shares purchased during or after the IPO in favor of approving a business combination. Additionally,
each Public Stockholder may elect to redeem their Public Shares without voting, and if they do vote, irrespective of whether they vote
for or against the proposed transaction.
Notwithstanding
the foregoing, the Charter provides that a Public Stockholder, together with any affiliate of such stockholder or any other person with
whom such stockholder is acting in concert or as a “group” (as defined under Section 13 of the Securities Exchange Act of
1934, as amended (the “Exchange Act”)), will be restricted from redeeming its shares with respect to more than an aggregate
of 20% or more of the Class A common stock sold in the IPO, without the prior consent of the Company.
The
Company’s Sponsor, officers and directors (the “Initial Stockholders”) have agreed not to propose an amendment to the
Charter that would affect the substance or timing of the Company’s obligation to redeem 100% of its Public Shares if the Company
does not complete a business combination within the business combination period, unless the Company provides the Public Stockholders
with the opportunity to redeem their shares of Class A common stock in conjunction with any such amendment.
On
December 16, 2022, the Company held a special meeting of its stockholders (the “First Special Meeting”). At the Special Meeting,
the Company’s stockholders approved an amendment (the “First IMTA Amendment”) to the Company’s Investment Management
Trust Agreement (the “IMTA”), dated October 5, 2021, with Continental Stock Transfer & Trust Company (“CST”),
as trustee, and an amendment to the Company’s Charter (the “First Charter Amendment”), to extend the business combination
period up to three times for three months each time (the “First Extension”).
In
connection with the First Special Meeting, the Sponsor agreed that if the First Charter Amendment and the First IMTA Amendment were approved
at the First Special Meeting, the Sponsor, or one or more of its affiliates, members or third-party designees (in such capacity, the
“Lender”), would lend to the Company up to $1,500,000 to be deposited into the Trust Account established in connection with
the IPO. Accordingly, on December 20, 2022, the Company issued an unsecured promissory note in the principal amount of $1,500,000 (the
“Promissory Note”) to the Lender, pursuant to which the Lender agreed to loan to the Company up to $1,500,000 in connection
with the extension of the date by which the Company has to consummate an initial Business Combination.
In
connection with the approval of the Extension, holders of 16,211,702 Public Shares exercised redemption rights. As a result, following
the satisfaction of such redemptions, as of December 31, 2022, the Company had 2,173,298 shares of Class A common stock outstanding,
of which (i) 1,288,298 were Public Shares, which were entitled to receive a pro rata portion of the remaining funds in the Trust Account
in connection with its initial Business Combination, a liquidation or certain other events, and (ii) 885,000 were Private Placement Shares,
which did not have redemption rights. On
March 31, 2023, May 8, 2023 and June 30, 2023, the Company deposited $100,000, $125,000 and $150,000 into the Trust Account in connection
with the First Extension.
On
July 7, 2023, the Company held a special meeting of its stockholders (the “Second Special Meeting”). At the Second Special
Meeting, the Company’s stockholders approved an amendment to the IMTA, as amended by the IMTA Amendment (the “Second IMTA
Amendment”), and an amendment to the Company’s Charter, as amended by the Charter Amendment (the “Second Charter Amendment”),
to extend the business combination period for up to six times for one month each time (the “Second Extension”).
On July 7, 2023, July 28,
2023, September 1, 2023, October 4, 2023, November 2, 2023 and November 30, 2023, the Company deposited $37,052, $8,846, $22,949, $22,949,
$22,949 and $22,949 into the Trust Account in connection with the Second Extension.
As
a result of the deposits described above, such payments and accrual of interest, the balance in the Trust Account as of December 31,
2023 is approximately $8.4 million.
If
the Company is unable to complete a business combination by January 8, 2024 (as extended) (the “business combination period”),
the Company will (i) cease all operations except for the purpose of winding up, (ii) as promptly as reasonably possible but not more
than ten business days thereafter, redeem the Public Shares, at a per-share price, payable in cash, equal to the aggregate amount then
on deposit in the Trust Account including interest earned on the funds held in the Trust Account and not previously released to us to
pay the Company’s franchise and income taxes (less up to $100,000 of interest to pay dissolution expenses), divided by the number
of then outstanding Public Shares, which redemption will completely extinguish Public Stockholders’ rights as stockholders (including
the right to receive further liquidating distributions, if any), subject to applicable law, and (iii) as promptly as reasonably possible
following such redemption, subject to the approval of the Company’s remaining stockholders and the Company’s board of directors,
dissolve and liquidate, subject in each case to the Company’s obligations under Delaware law to provide for claims of creditors
and the requirements of other applicable law.
The
Initial Stockholders have agreed to waive their liquidation rights with respect to the Founder Shares and Private Placement Shares if
the Company fails to complete a business combination within the business combination period. However, if the Initial Stockholders should
acquire Public Shares in or after the IPO, they will be entitled to liquidating distributions from the Trust Account with respect to
such Public Shares if the Company fails to complete a business combination within the business combination period. The underwriter has
agreed to waive its rights to the deferred underwriting commission (see Note 6) held in the Trust Account in the event the Company does
not complete a business combination within the business combination period, and, in such event, such amounts will be included with the
other funds held in the Trust Account that will be available to fund the redemption of the Public Shares. In the event of such distribution,
it is possible that the per share value of the residual assets remaining available for distribution (including Trust Account assets)
will be only $10.20 per share held in the Trust Account. In order to protect the amounts held in the Trust Account, the Sponsor has agreed
to be liable to the Company if and to the extent any claims by a vendor for services rendered or products sold to the Company, or a prospective
target business with which the Company has discussed entering into a transaction agreement, reduce the amount of funds in the Trust Account.
This liability will not apply with respect to any claims by a third party who executed a waiver of any right, title, interest or claim
of any kind in or to any monies held in the Trust Account or to any claims under the Company’s indemnity of the underwriter of
the IPO against certain liabilities, including liabilities under the Securities Act of 1933, as amended (the “Securities Act”).
Moreover, in the event that an executed waiver is deemed to be unenforceable against a third party, the Sponsor will not be responsible
to the extent of any liability for such third-party claims.
The
Company will seek to reduce the possibility that the Sponsor will have to indemnify the Trust Account due to claims of creditors by endeavoring
to have all vendors, service providers (except the Company’s independent registered public accounting firm), prospective target
businesses or other entities with which the Company does business, execute agreements waiving any right, title, interest or claim of
any kind in or to monies held in the Trust Account.
Business
Combination Agreement with CERo Therapeutics, Inc. (“CERo”)
On June 4, 2023, the Company entered into a business combination
agreement and plan of reorganization (the “Business Combination Agreement”), by and among the Company, PBCE Merger Sub, Inc.,
a Delaware corporation (“Merger Sub”), and CERo. Immediately after the merger, the Company changed its name from Phoenix Biotech
Acquisition Corporation to CERo Therapeutics Holdings, Inc. At the effective time (the “Effective Time”) of the of
the merger between Merger Sub and CERo (the “Business Combination”), (i) each outstanding share of CERo common stock,
par value $0.0001 per share (the “CERo common stock”), will be cancelled and converted into (a) the right to receive
a number of shares of Class A common stock, par value $0.0001 per share (“Class A common stock”), equal to $50,000,000, minus the
Aggregate Liquidation Preference (as defined in the Business Combination Agreement), divided by the Fully Diluted Company
Capitalization (as defined in the Business Combination Agreement), divided by $10.00 (the “Exchange Ratio”)
and (b) the right to receive a portion of up to 2,200,000 additional shares of Class A common stock if certain trading price
hurdles are achieved or a Change of Control (as defined in the Business Combination Agreement) occurs within four years after the Closing
(“Earnout Shares”); (ii) each outstanding option to purchase CERo common stock (each, a “CERo option”) will
be converted into an option to purchase a number of shares of Class A common stock, equal to (A) the number of shares of CERo
common stock subject to such option immediately prior to the Effective Time, multiplied by (B) the Exchange Ratio,
at an exercise price per share equal to the current exercise price per share for such option divided by the Exchange Ratio; in each case,
rounded down to the nearest whole share, and rounded up to the nearest whole cent in the case of the exercise price of the CERo options;
(iii) each outstanding share of CERo preferred stock, par value $0.0001 per share (the “CERo preferred stock”), will
be converted into a number of shares of Class A common stock, equal to the number of shares of Class A common stock obtained
by dividing the liquidation preference thereof by $10.00 and the contingent right to receive such holder’s Earn-Out Pro
Rata Portion (as defined in the Business Combination Agreement), and (iv) each warrant to purchase CERo preferred stock (each, a
“CERo warrant”) outstanding as of immediately prior to the Effective Time will be converted into a warrant to acquire a number
of shares of Class A common stock equal to the number of shares of CERo preferred stock subject to the corresponding warrant immediately
prior to the Effective Time, multiplied by the Aggregate Liquidation Preference of such underlying shares of CERo preferred
stock, and divided by $10.00, with the exercise price per share for such warrant equal to (A) the current aggregate
exercise price of such warrant (the current exercise price per share of CERo preferred stock applicable to the corresponding warrant immediately
prior to the Effective Time, multiplied by the number of shares of CERo preferred stock issuable upon exercise thereof), divided by
(B) the number of shares of Class A common stock issuable upon exercise thereof. Subject to certain exceptions, such terms and
conditions applicable to a CERo Therapeutics Holdings, Inc. (“New CERo”) warrant will be the same terms and conditions as
were applicable to a CERo warrant immediately prior to the Effective Time. The Company will issue an aggregate of approximately 5.0 million
shares of Class A common stock to the holders of CERo common stock and CERo preferred stock as consideration in the Business Combination.
NASDAQ
Notice
On
April 3, 2023, the Company received a letter (the “Letter”) from the staff at The Nasdaq Global Market (“Nasdaq”)
notifying the Company that, for the 30 consecutive trading days prior to the date of the Letter, the Company’s common stock had
traded at a value below the minimum $50,000,000 “Market Value of Listed Securities” (“MVLS”) requirement set
forth in Nasdaq Listing Rule 5450(b)(2)(A), which is required for continued listing of the Company’s common stock on Nasdaq. The
Letter is only a notification of deficiency, not of imminent delisting, and has no current effect on the listing or trading of the Company’s
securities on Nasdaq.
In
order to bring the Company into compliance with the MVLS requirement, on July 3, 2023, the Sponsor elected to effect the Conversion.
As of the date hereof, there are 6,246,207 shares of Class A common stock and no shares of Class B common stock issued and outstanding
and entitled to vote.
On
September 7, 2023, the Company received a written notice (the “Notice”) from the Nasdaq Listing Qualifications Department
of Nasdaq indicating that the Company was not in compliance with Listing Rule 5450(a)(2), which requires the Company to have at least
400 public holders for continued listing on the Nasdaq Global Market (the “Minimum Public Holders Rule”). The Notice is only
a notification of deficiency, not of imminent delisting, and has no current effect on the listing or trading of the Company’s securities
on Nasdaq Global Market. The Notice states that the Company has 45 calendar days to submit a plan to regain compliance with the Minimum
Public Holders Rule. The Company has submitted a plan to regain compliance with the Minimum Public Holders Rule. If Nasdaq accepts the
Company’s plan, Nasdaq may grant the Company an extension of up to 180 calendar days from the date of the Notice to evidence compliance
with the Minimum Public Holders Rule. If Nasdaq does not accept the Company’s plan, the Company will have the opportunity to appeal
the decision in front of a Nasdaq Hearings Panel.
The
MVLS deficiency was cured by the conversion of the Class B common stock into Class A common stock because the Class A common stock held
by Sponsor count towards satisfying such requirement. The Company submitted a “plan of compliance” to NASDAQ indicating that
the Company was aiming to be able to cure the deficiency upon closing of the Business Combination. Nasdaq has not responded. Inflation
Reduction Act of 2022 (the “IR Act”)
On
August 16, 2022, the Inflation Reduction Act of 2022 (the “IR Act”) was signed into federal law. The IR Act provides for,
among other things, a new U.S. federal 1% excise tax on certain repurchases of stock by publicly traded U.S. domestic corporations and
certain U.S. domestic subsidiaries of publicly traded foreign corporations occurring on or after January 1, 2023. The excise tax is imposed
on the repurchasing corporation itself, not its stockholders from which shares are repurchased. The amount of the excise tax is generally
1% of the fair market value of the shares repurchased at the time of the repurchase. However, for purposes of calculating the excise
tax, repurchasing corporations are permitted to net the fair market value of certain new stock issuances against the fair market value
of stock repurchases during the same taxable year. In addition, certain exceptions apply to the excise tax. The U.S. Department of the
Treasury (the “Treasury”) has been given authority to provide regulations and other guidance to carry out and prevent the
abuse or avoidance of the excise tax.
Any
redemption or other repurchase that occurs after December 31, 2022, in connection with a business combination, extension vote or otherwise,
may be subject to the excise tax. Whether and to what extent the Company would be subject to the excise tax in connection with a business
combination, extension vote or otherwise would depend on a number of factors, including (i) the fair market value of the redemptions
and repurchases in connection with the business combination, extension or otherwise, (ii) the structure of a business combination, (iii)
the nature and amount of any “PIPE” or other equity issuances in connection with a business combination (or otherwise issued
not in connection with a business combination but issued within the same taxable year of a business combination) and (iv) the content
of regulations and other guidance from the Treasury. In addition, because the excise tax would be payable by the Company and not by the
redeeming holder, the mechanics of any required payment of the excise tax have not been determined. The foregoing could cause a reduction
in the cash available on hand to complete a business combination and in the Company’s ability to complete a business combination.
On
July 17, 2023, the Company redeemed 523,341 shares of Class A common stock tendered for redemption by the Public Stockholders for a total
redemption amount of $5,638,879 in connection with the implementation of the Extension. The Company evaluated the classification and
accounting of the stock redemption under ASC 450, “Contingencies” to determine whether the Company should currently recognize
an excise tax obligation associated therewith. ASC 450 states that when a loss contingency exists the likelihood that the future event(s)
will confirm the loss or impairment of an asset, or the incurrence of a liability can range from probable to remote. Contingent liability
must be reviewed at each reporting period to determine appropriate treatment. The Company evaluated whether a United States excise tax
obligation should be recognized currently related to the stock redemption and concluded that this obligation should be recognized. As
of December 31, 2023, the Company recorded $56,389 of excise tax liability calculated as 1% of shares redeemed on July 17, 2023. Any
reduction to this liability resulting from either a subsequent stock issuance or an event giving rise to an exception that occurs within
this tax year, will be recognized in the period (including an interim period) that such stock issuance or event giving rise to an exception
occurs.
Liquidity
and Going Concern
As
of December 31, 2023, the Company had $96,873 in its operating bank accounts, $8,436,311 in marketable securities held in the Trust Account
to be used for a business combination or to repurchase or redeem its Public Shares in connection therewith and a working capital deficit
of $5,049,122.
On
May 9, 2023, the Company received a notice from the IRS stating an additional $182,308 of federal income taxes were due by May 22, 2023.
The Company made this payment on June 23, 2023.
The accompanying financial
statements have been prepared assuming that the Company will continue as a going concern, which contemplates the realization of assets
and satisfaction of liabilities in the normal course of business. The Company’s ability to continue as a going concern is dependent
on its ability to raise additional capital to fund its research and development (“R&D”) activities and meet its obligations
on a timely basis. Since inception, the Company has incurred net losses and operating cash flow deficits, resulting in an accumulated
deficit of $14.2 million as of December 31, 2023. On February 14, 2024, the Company acquired the assets of CERo Therapeutics, Inc.,
closed a private placement with gross proceeds of $9.98 million, and assumed the R&D operations of CERo Therapeutics. Additional funds
are necessary to maintain current operations and to continue R&D activities. However, there can be no assurance that sufficient funding
will be available to allow the Company to successfully continue its R&D activities and planned regulatory filings with the Food and
Drug Administration (“FDA”). If the Company is unable to obtain necessary funds, significant reductions in spending and the
delay or cancellation of planned activities may be necessary. These actions would have a material adverse effect on the Company’s
business, results of operations, and prospects. These conditions raise substantial doubt about the Company’s ability to continue
as a going concern within one year from the date these financial statements are issued. The accompanying financial statements do not include
any adjustments relating to the recoverability and classification of recorded asset amounts or the amounts and classification of liabilities
that might result from the outcome of this uncertainty.
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v3.24.1
Summary of Significant Accounting Policies
|
12 Months Ended |
Dec. 31, 2023 |
Summary of Significant Accounting Policies [Abstract] |
|
Summary of Significant Accounting Policies |
Note
2 — Summary of Significant Accounting Policies
Basis
of Presentation
The
accompanying financial statements are presented in accordance with accounting principles generally accepted in the United States of America
(“GAAP”) and pursuant to the rules and regulations of the SEC.
Reclassifications
Certain
prior year amounts have been reclassified due to an immaterial correction of an error and for consistency with the current period presentation.
These reclassifications had no effect on the reported results of operations. An adjustment for $244,777 has been made to Class A
common stock subject to possible redemption and Accumulated deficit as of December 31, 2022 to correct the total amount redeemable
to stockholders.
In the Form 10-Q for three
months ended March 31, 2023, the Company discovered an error in the Statement of Cash Flows for the presentation of restricted cash. The
error was not corrected and persisted in the statements of cash flows in the quarterly reports on 10-Q for the three months ended June
30, 2023 and September 30, 2023. These errors had no impact on the balance sheets or the statements of operations in those periods. This
error is corrected in the statement of cash flows in the Company’s December 31, 2023 audited financial statements.
Emerging
Growth Company
The
Company is an “emerging growth company,” as defined in Section 2(a) of the Securities Act, as modified by the Jumpstart Our
Business Startups Act of 2012 (the “JOBS Act”), and it may take advantage of certain exemptions from various reporting requirements
that are applicable to other public companies that are not emerging growth companies including, but not limited to, not being required
to comply with the independent registered public accounting firm attestation requirements of Section 404 of the Sarbanes-Oxley Act, reduced
disclosure obligations regarding executive compensation in its periodic reports and proxy statements, and exemptions from the requirements
of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously
approved.
Further,
Section 102(b)(1) of the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting
standards until private companies (that is, those that have not had a Securities Act registration statement declared effective or do
not have a class of securities registered under the Exchange Act) are required to comply with the new or revised financial accounting
standards. The JOBS Act provides that a company can elect to opt out of the extended transition period and comply with the requirements
that apply to non-emerging growth companies but any such election to opt out is irrevocable. The Company has elected not to opt out of
such extended transition period which means that when a standard is issued or revised and it has different application dates for public
or private companies, the Company, as an emerging growth company, can adopt the new or revised standard at the time private companies
adopt the new or revised standard. This may make comparison of the Company’s financial statements with another public company which
is neither an emerging growth company nor an emerging growth company which has opted out of using the extended transition period difficult
or impossible because of the potential differences in accounting standards used.
Use
of Estimates
The
preparation of financial statements in conformity with U.S. GAAP requires the Company’s management to make estimates and assumptions
that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the reporting period.
Making
estimates requires management to exercise significant judgment. Such estimates may be subject to change as more current information becomes
available and accordingly the actual results could differ significantly from those estimates. It is at least reasonably possible that
the estimate of the effect of a condition, situation or set of circumstances that existed at the date of the financial statements, which
management considered in formulating its estimate, could change in the near term due to one or more future confirming events. Actual
results could differ from those estimates.
Cash
and Cash Equivalents
The
Company considers all short-term investments with an original maturity of three months or less when purchased to be cash equivalents.
The Company did not have any cash equivalents as of December 31, 2023 and 2022. Restricted
Cash
The
Company considers all cash to be held for a specific purpose restricted cash. As of December 31, 2023 and 2022, the Company had $0 and
$41,665,974 in restricted cash, respectively. The restricted cash as of December 31, 2022 was intended to satisfy stockholder redemption
payments. The cash and restricted cash balances included in the balance sheets as of December 31, 2023 and 2022, are comprised of
the following:
| |
December 31, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Cash | |
$ | 96,873 | | |
$ | 475,870 | |
Restricted cash | |
| — | | |
| 41,665,974 | |
Total cash and restricted cash | |
$ | 96,873 | | |
$ | 42,141,844 | |
Money
Market Funds Held in Trust Account
At
December 31, 2023, the assets held in Trust Account were held in money market funds that invested in U.S. Treasury securities. At December 31,
2022, substantially all of the assets held in the Trust Account were held as cash. The Company’s investments held in the Trust
Account are classified as trading securities. Trading securities are presented on the balance sheets at fair value at the end of each
reporting period. Gains and losses resulting from the change in fair value of investments held in the Trust Account and interest
earned on marketable securities are included in the accompanying statements of operations. The estimated fair values of investments held
in the Trust Account are determined using available market information.
Shareholder
Redemption Liability
On
December 20, 2022, in connection with the Company’s special meeting held to consider the First Charter Amendment, the Company’s
stockholders redeemed 16,211,702 shares of Class A common stock subject to possible redemption at $10.20 per share redemption
value, plus a pro rata share of interest earned. Of the total amount redeemed, payments for 2,581,004 shares of Class A
common stock totaling $26,481,101 plus a true-up payment of $1,361,646 for a total liability of $27,842,747 were subsequently paid to
redeeming stockholders on January 3, 2023. Therefore, a portion of the total redemption payment has been classified as a stockholder
redemption liability in the accompanying balance sheet as of December 31, 2022.
Offering
Costs Associated with the IPO
Offering
costs, including additional underwriting fees associated with the underwriter’s partial exercise of the over-allotment option,
consist principally of legal, accounting, underwriting fees and other costs directly related to the IPO. Offering costs, including those
attributable to the underwriter’s partial exercise of the over-allotment option, amounted to $12,729,318. This amount was charged
to stockholders’ deficit upon the completion of the IPO.
Concentration
of Credit Risk
Financial
instruments that potentially subject the Company to concentrations of credit risk consist of cash accounts in a financial institution,
which, at times, may exceed the Federal Deposit Insurance Corporation coverage limit of $250,000. At December 31, 2023 and 2022, the
Company has not experienced losses on these accounts and management believes the Company is not exposed to significant risks on such
accounts.
Fair
Value of Financial Instruments
The
fair value of the Company’s financial assets and liabilities reflects management’s estimate of amounts that the Company would
have received in connection with the sale of the assets or paid in connection with the transfer of the liabilities in an orderly transaction
between market participants at the measurement date. In connection with measuring the fair value of its assets and liabilities, the Company
seeks to maximize the use of observable inputs (market data obtained from independent sources) and to minimize the use of unobservable
inputs (internal assumptions about how market participants would price assets and liabilities). The following fair value hierarchy is
used to classify assets and liabilities based on the observable inputs and unobservable inputs used in order to value the assets and
liabilities:
Level 1:
Quoted prices in active markets for identical assets or liabilities. An active market for an asset or liability is a market in which
transactions for the asset or liability occur with sufficient frequency and volume to provide pricing information on an ongoing basis. Level 2:
Observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar
assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.
Level 3:
Unobservable inputs based on the Company’s assessment of the assumptions that market participants would use in pricing the asset
or liability.
Income
Taxes
The
Company complies with the accounting and reporting requirements of ASC 740, “Income Taxes” (“ASC 740”), which
requires an asset and liability approach to financial accounting and reporting for income taxes. Deferred income tax assets and liabilities
are computed for differences between the financial statement and tax bases of assets and liabilities that will result in future taxable
or deductible amounts, based on enacted tax laws and rates applicable to the periods in which the differences are expected to affect
taxable income. Valuation allowances are established, when necessary, to reduce deferred tax assets to the amount expected to be realized.
ASC
740 prescribes a recognition threshold and a measurement attribute for the financial statement recognition and measurement of tax positions
taken or expected to be taken in a tax return. For those benefits to be recognized, a tax position must be more likely than not to be
sustained upon examination by taxing authorities. There were no unrecognized tax benefits as of December 31, 2023 and 2022. The Company
recognizes accrued interest and penalties related to unrecognized tax benefits as income tax expense. No amounts were accrued for the
payment of interest and penalties at December 31, 2023 and 2022. The Company is currently not aware of any issues under review that could
result in significant payments, accruals, or material deviation from its position. The Company is subject to income tax examinations
by major taxing authorities since inception.
Deferred
tax liabilities and assets are determined based on the difference between the financial statement and tax basis of assets and liabilities,
using enacted tax rates in effect for the year in which the differences are expected to reverse. Current income taxes are based on the
year’s income taxable for federal and state income tax reporting purposes. Total tax provision may differ from the statutory tax
rates applied to income before provision for income taxes due principally to expenses charged which are not tax deductible.
The
total provision benefit for income taxes is comprised of the following:
| |
December 31,
2023 | | |
December 31,
2022 | |
Current expense | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
Deferred tax benefit | |
| — | | |
| — | |
Change
in valuation allowance | |
| — | | |
| — | |
Total
income tax (expense) benefit | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
The
net deferred tax assets in the accompanying balance sheets included the following components:
| |
December 31,
2023 | | |
December 31,
2022 | |
Deferred tax assets | |
$ | 607,516 | | |
$ | 596,692 | |
Deferred tax liabilities | |
| — | | |
| — | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Net
deferred tax assets | |
$ | — | | |
$ | — | |
The
deferred tax assets as of December 31, 2023 and 2022 were comprised of the tax effect of cumulative temporary differences as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
General and administration
expenses before business combination | |
$ | 607,516 | | |
$ | 596,692 | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Total | |
$ | — | | |
$ | — | |
In
assessing the realization of deferred tax assets, management considers whether it is more likely than not that some portion or all of
the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future
taxable income during the periods in which temporary differences representing net future deductible amounts become deductible. Management
considers the scheduled reversal of deferred tax assets, projected future taxable income and tax planning strategies in making this assessment.
For the year ended December 31, 2023 and 2022, the valuation allowance was $607,516 and $596,692, respectively.
A
reconciliation of the statutory federal income tax provision (benefit) to the Company’s effective tax rate is as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
Statutory
federal income tax rate | |
| 21.0 | % | |
| 21.0 | % |
State
taxes, net of federal tax benefit | |
| 0.0 | % | |
| 0.0 | % |
Valuation
allowance | |
| (17.33 | )% | |
| 852.7 | % |
Income
tax provision (benefit) | |
| 3.67 | % | |
| 873.7 | % |
Class A
Common Stock Subject to Possible Redemption
The
Company accounts for its Class A common stock subject to possible redemption in accordance with the guidance in ASC 480. Shares
of Class A common stock subject to mandatory redemption (if any) are classified as a liability instrument and are measured at fair
value. Conditionally redeemable Class A common stock (including Class A common stock that features redemption rights that are within
the control of the holder or subject to redemption upon the occurrence of uncertain events not solely within the Company’s control)
is classified as temporary equity. At all other times, Class A common stock is classified as stockholders’ equity. The Company’s
Class A common stock features certain redemption rights that are considered to be outside of the Company’s control and subject
to occurrence of uncertain future events. Accordingly, at December 31, 2023 and 2022, 764,957 and 1,288,298 shares of Class A common
stock subject to possible redemption are presented as temporary equity, outside of the stockholders’ deficit section of the Company’s
balance sheets.
The
Company recognizes changes in redemption value immediately as they occur and adjusts the carrying value of redeemable Class A common
stock to equal the redemption value at the end of each reporting period. Increases or decreases in the carrying amount of redeemable
common stock are affected by charges against additional paid in capital and accumulated deficit.
At
December 31, 2023 and 2022, the Class A common stock subject to possible redemption reflected in the balance sheets is reconciled
in the following table:
Class A common stock subject to possible redemption, December 31, 2021 | |
$ | 178,500,000 | |
Plus: Accretion of carrying value to redemption value | |
| 2,662,553 | |
Less: redemption of shares | |
| (167,693,708 | ) |
Class A common stock subject to possible redemption, December 31, 2022 | |
$ | 13,468,845 | |
Less: Redemption | |
| (5,638,880 | ) |
Plus: Accretion of carrying value to redemption value | |
| 606,346 | |
Class A common stock subject to possible redemption, December 31, 2023 | |
$ | 8,436,311 | |
Net
Loss per Common Stock
The
Company has two classes of shares, which are referred to as Class A common stock and Class B common stock (the “Class
B common stock” or the “Founder Shares”). Earnings and losses are shared pro rata between the two classes of shares.
Public Warrants (see Note 3) and Private Placement Warrants (see Note 4) to purchase an aggregate of 9,192,500 shares of Class A
common stock at $11.50 per share were issued on October 29, 2021. At December 31, 2023 and December 31, 2022, no Public
Warrants or Private Placement Warrants have been exercised. The 9,192,500 shares of Class A common stock underlying outstanding
Public Warrants and Private Placement Warrants were excluded from diluted net income per share for the year ended December
31, 2023 and 2022 because they are contingently exercisable, and the contingencies have not yet been met. As a result, diluted net income
per common stock is the same as basic net income per common stock for the period. The tables below present a reconciliation of the numerator
and denominator used to compute basic and diluted net income per share for each class of stock.
| |
For
the Year Ended December 31, | |
| |
2023 | | |
2022 | |
| |
Class A
common stock | | |
Class B
Common stock | | |
Class A
common stock | | |
Class B
Common stock | |
Basic and diluted net income per share: | |
| | |
| | |
| | |
| |
Numerator: | |
| | |
| | |
| | |
| |
Allocation
of net income | |
$ | (1,641,020 | ) | |
$ | (895,213 | ) | |
$ | (531,288 | ) | |
$ | (136,448 | ) |
Denominator: | |
| | | |
| | | |
| | | |
| | |
Weighted
average shares outstanding | |
| 4,224,247 | | |
| 2,304,421 | | |
| 17,896,428 | | |
| 4,596,250 | |
Basic and diluted net income per share | |
$ | (0.39 | ) | |
$ | (0.39 | ) | |
$ | (0.03 | ) | |
$ | (0.03 | ) |
Accounting
for Warrants
The
Company accounts for warrants as either equity-classified or liability-classified instruments based on an assessment of the instruments’
specific terms and applicable authoritative guidance in ASC 480 and ASC 815, Derivatives and Hedging. The assessment considers
whether the instruments are free standing financial instruments pursuant to ASC 480, meet the definition of a liability pursuant to ASC
480, and whether the instruments meet all of the requirements for equity classification under ASC 815, including whether the instruments
are indexed to the Company’s own common stock and whether the instrument holders could potentially require “net cash settlement”
in a circumstance outside of the Company’s control, among other conditions for equity classification. This assessment, which requires
the use of professional judgment, was conducted at the time of warrant issuance and as of each subsequent period end date while the instruments
are outstanding. Management has concluded that the Public Warrants and Private Placement Warrants issued pursuant to the warrant agreement
qualify for equity accounting treatment.
Recent
Accounting Pronouncements
In
December 2023, the FASB issued ASU 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures (ASU 2023-09), which requires
disclosure of incremental income tax information within the rate reconciliation and expanded disclosures of income taxes paid, among
other disclosure requirements. ASU 2023-09 is effective for fiscal years beginning after December 15, 2024. Early adoption is permitted.
The Company’s management does not believe the adoption of ASU 2023-09 will have a material impact on its consolidated financial statements
and disclosures.
Management
does not believe that any other recently issued, but not yet effective, accounting standards if currently adopted would have a material
effect on the accompanying unaudited condensed financial statements.
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- DefinitionThe entire disclosure for all significant accounting policies of the reporting entity.
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v3.24.1
Initial Public Offering and Over-Allotment
|
12 Months Ended |
Dec. 31, 2023 |
Initial Public Offering and Over-Allotment [Abstract] |
|
Initial Public Offering and Over-Allotment |
Note
3 — Initial Public Offering and Over-Allotment
Pursuant
to the IPO, the Company sold 17,500,000 units (including 2,000,000 units as part of the underwriter’s partial exercise of the over-allotment
option) at a price of $10.00 per Unit. Each Unit consists of one Public Share, and a Public Warrant. Each Public Warrant entitles the
holder to purchase one share of Class A common stock at a price of $11.50 per share, subject to adjustment (see Note 7).
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v3.24.1
Private Placement Warrants
|
12 Months Ended |
Dec. 31, 2023 |
Private Placement Warrants [Abstract] |
|
Private Placement Warrants |
Note
4 — Private Placement Warrants
On
October 8, 2021, simultaneously with the consummation of the IPO, the Company consummated the issuance and sale (“Private
Placement”) of the Private Placement Units in a private placement transaction at a price of $10.00 per Private Placement Unit,
generating gross proceeds of $8,850,000. The Private Placement Units were purchased by Cantor (155,000 Units), CCM (30,004 Units) and
the Sponsor (699,996 Units). Each whole Private Placement Unit consists of one Private Placement Share and one-half of a redeemable
warrant (“Private Placement Warrant”). Each whole Private Placement Warrant will be exercisable to purchase one share
of Class A common stock at a price of $11.50 per share, subject to adjustment. A portion of the proceeds from the Private Placement
Units was added to the proceeds from the IPO to be held in the Trust Account. If the Company does not complete a business combination
within the Combination Period, the proceeds from the sale of the Private Placement Units will be used to fund the redemption of the Public
Shares (subject to the requirements of applicable law), and the Private Placement Units and all underlying securities will be worthless.
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v3.24.1
Related Party Transactions
|
12 Months Ended |
Dec. 31, 2023 |
Related Party Transactions [Abstract] |
|
Related Party Transactions |
Note
5 — Related Party Transactions
Founder
Shares
On
September 18, 2021, the Sponsor provided funds to pay for certain costs totaling $25,000 on behalf of the Company as consideration
for 4,598,750 Founder Shares. Later in September 2021, the Company effected a 0.017 for 1 stock dividend for each Founder Share
outstanding, and, as a result, the Sponsor held 4,679,125 Founder Shares following the stock dividend. As a result, the Company’s
shares have been retroactively adjusted for this stock dividend; however, due to the shares being closely held the corresponding earnings
have not been capitalized from retained earnings. The Sponsor agreed to forfeit up to 592,875 Founder Shares to the extent that the 45-day
over-allotment option was not exercised in full by the underwriter. Since the underwriter exercised the over-allotment option only in
part, the Sponsor forfeited 82,875 Founder Shares.
The
Sponsor has agreed, subject to limited exceptions, not to transfer, assign or sell any of the Founder Shares until the earliest of: (a) one
year after the completion of a business combination and (b) subsequent to a business combination, (x) if the closing price
of the shares of Class A common stock equals or exceeds $12.00 per share (as adjusted) for any 20 trading days within any 30-trading day
period commencing at least 150 days after a business combination, or (y) the date on which the Company completes a liquidation,
merger, share exchange or other similar transaction that results in all of the Public Stockholders having the right to exchange their
shares of Class A common stock for cash, securities or other property.
On
July 3, 2023, the Sponsor delivered a notice of conversion of an aggregate of 4,596,250 Founder Shares into an equal number of shares
of Class A common stock. Such Founder Shares were subsequently converted into Class B common stock.
Related
Party Loans
On
June 18, 2021, the Sponsor agreed to loan the Company an aggregate of up to $300,000 to cover expenses related to the IPO pursuant
to a promissory note which was amended on September 10, 2021 (as amended, the “Note”). This loan is non-interest-bearing.
There was no balance on the Note as of December 31, 2023 and 2022.
In
addition, in order to finance transaction costs in connection with a business combination, the Sponsor or an affiliate of the Sponsor,
or certain of the Company’s officers and directors may, but are not obligated to, loan the Company funds as may be required (“Working
Capital Loans”). If the Company completes a business combination, the Company would repay the Working Capital Loans out of the
proceeds of the Trust Account released to the Company. Otherwise, the Working Capital Loans would be repaid only out of funds held outside
the Trust Account. In the event that a business combination does not close, the Company may use a portion of proceeds held outside the
Trust Account to repay the Working Capital Loans but no proceeds held in the Trust Account would be used to repay the Working Capital
Loans. The Working Capital Loans will either be repaid upon consummation of a business combination, without interest, or, at the lender’s
discretion, up to $1.5 million of such Working Capital Loans may be convertible into units of the post business combination entity
at a price of $10.00 per unit. The units would be identical to the Private Placement Units. On December 13, 2022, the Company entered
into a promissory note with the Sponsor. In order to fund ongoing operations, the Sponsor will loan up to $1,500,000 to the Company. The
Promissory Note does not bear interest and matures upon the earlier of (a) the closing of an initial business combination and (b) the
Company’s liquidation. In the event that the Company does not consummate an initial business combination, the Promissory Note will
be repaid only from amounts remaining outside of the Trust Account, if any. On December 8, 2023, the Company and the Lender amended the
Promissory Note to increase the aggregate principal amount of the Promissory Note from $1,500,000 to $1,600,000. All other material terms
of the Promissory Note remain in full force and effect. On May 8, 2023, June 9, 2023, September 12, 2023 and December 18,
2023, the sponsor loaned the company $250,000, $275,000, $220,000 and $160,000 under the Promissory Note in connection with extensions
of the Company’s liquidation date, respectively. As of December 31, 2023 and 2022, there was $1,555,000 and $650,000 in borrowings
under the Working Capital Loans, respectively.
Consulting
Services
The
Company entered into an agreement, commencing on the date of its listing on Nasdaq, to pay the spouse of the Company’s Chief Executive
Officer a monthly consulting fee of $15,000 for assisting the Company in identifying and evaluating potential acquisition targets. Upon
completion of the Company’s initial business combination or the Company’s liquidation, the Company’s will cease paying
these monthly fees. The payments ended on December 31, 2022 in connection with the approval of the Charter Amendment. For the year ended
December 31, 2023, $0 has been incurred under this agreement. For the year ended December 31, 2022, $180,000 has been incurred under
this agreement, respectively.
Advisory
Services
The
Company engaged CCM, an affiliate of the Company, the Sponsor and/or certain of its directors and officers, to provide consulting and
advisory services in connection with the IPO, for which it was entitled to a fee in an amount equal to $465,000, which was paid to CCM
upon the closing of the IPO, and $1,162,500, which will be paid to CCM upon the closing of the Company’s initial business combination.
Affiliates of CCM have and manage investment vehicles with a passive investment in the Sponsor. Support
Services
The
Company entered into an agreement, commencing on the date of its listing on Nasdaq through the earlier of the consummation of a business
combination and the Company’s liquidation, to pay an affiliate of the Sponsor a monthly fee of $20,000 for office space, secretarial
and administrative services. Payments under the agreement were suspended on December 31, 2022 and reinstated on March 31, 2023. For the
year ended December 31, 2023, $200,000 has been incurred under this agreement. For the year ended December 31, 2022, $240,000 has been
incurred under this agreement, respectively. As of December 31, 2023, there was a $75,000 outstanding balance owed to the Sponsor.
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v3.24.1
Commitments and Contingencies
|
12 Months Ended |
Dec. 31, 2023 |
Commitments and Contingencies [Abstract] |
|
Commitments and Contingencies |
Note
6 — Commitments and Contingencies
Registration
Rights
Pursuant
to a registration rights agreement entered into on October 5, 2021, the holders of the Founder Shares, Private Placement Warrants
and warrants that may be issued upon conversion of Working Capital Loans (and any Class A common stock issuable upon the exercise
of the Private Placement Warrants and warrants that may be issued upon conversion of Working Capital Loans and upon conversion of the
Founder Shares) are entitled to registration rights, requiring the Company to register such securities and any other securities of the
Company acquired by them prior to the consummation of a business combination for resale. The holders of these securities are entitled
to make up to three demands, excluding short form demands, that the Company register such securities. In addition, the holders have certain
“piggy-back” registration rights with respect to registration statements filed subsequent to the completion of a business
combination. The registration rights agreement does not contain liquidated damages or other cash settlement provisions resulting from
delays in registering the securities. The Company will bear the expenses incurred in connection with the filing of any such registration
statements.
Underwriting
Agreement
The
Company granted the underwriter a 45-day option from the date of the final prospectus relating to the IPO to purchase up to
2,325,000 additional Units to cover over-allotments, if any, at the IPO price less the underwriting discounts and commissions. On October 8,
2021, the underwriter partially exercised its over-allotment option and purchased 2,000,000 units at $10.00 per unit.
The
underwriter was paid a cash underwriting discount of $0.20 per unit, or $3,100,000 in the aggregate at the closing of the IPO, of which
$465,000 was reimbursed to the Company to pay for additional advisors. The underwriter agreed to defer any additional fees related to
the exercise of the over-allotment option until the Company completes a business combination. As such, $400,000 of additional underwriting
fees related to the over-allotment have been deferred. In addition, the underwriter is entitled to deferred underwriting commissions
of $0.50 per unit, or $8,750,000 ($9,150,000 in the aggregate when including the $400,000 noted above) from the closing of the IPO. The
deferred fee will become payable to the underwriter from the amounts held in the Trust Account solely in the event that the Company completes
a business combination, subject to the terms of the underwriting agreement.
Business
Combination Agreement
On
June 4, 2023, the Company entered into the Business Combination Agreement.
At
the Effective Time, (i) each outstanding share of CERo common stock will be cancelled and converted into (a) the right to receive
a number of shares of Class A common stock, equal to $50,000,000, minus the Aggregate Liquidation Preference, divided by
the Fully Diluted Company Capitalization, divided by the Exchange Ratio and (b) the right to receive Earnout Shares;
(ii) each outstanding CERo option will be converted into an option to purchase a number of shares of Class A common stock,
equal to (A) the number of shares of CERo common stock subject to such option immediately prior to the Effective Time, multiplied by
(B) the Exchange Ratio, at an exercise price per share equal to the current exercise price per share for such option divided by
the Exchange Ratio; in each case, rounded down to the nearest whole share, and rounded up to the nearest whole cent in the case of the
exercise price of the CERo options; (iii) each outstanding share of CERo preferred stock, will be converted into a number of shares
of Class A common stock, equal to the number of shares of Class A common stock obtained by dividing the liquidation
preference thereof by $10.00 and the contingent right to receive such holder’s Earn-Out Pro Rata Portion, and (iv) each
CERo warrant outstanding as of immediately prior to the Effective Time will be converted into a warrant to acquire a number of shares
of Class A common stock equal to the number of shares of CERo preferred stock subject to the corresponding warrant immediately prior
to the Effective Time, multiplied by the Aggregate Liquidation Preference of such underlying shares of CERo preferred
stock, and divided by $10.00, with the exercise price per share for such warrant equal to (A) the current aggregate
exercise price of such warrant (the current exercise price per share of CERo preferred stock applicable to the corresponding warrant
immediately prior to the Effective Time, multiplied by the number of shares of CERo preferred stock issuable upon exercise
thereof), divided by (B) the number of shares of Class A common stock issuable upon exercise thereof. Subject
to certain exceptions, such terms and conditions applicable to a New CERo warrant will be the same terms and conditions as were applicable
to a CERo warrant immediately prior to the Effective Time. The Company will issue an aggregate of approximately 5.0 million shares
of Class A common stock to the holders of CERo common stock and CERo preferred stock as consideration in the Business Combination. Sponsor
Support Agreement
In
connection with the execution of the Business Combination Agreement, the Sponsor, as the sole holder of the Class B common stock,
and each of the Company’s officers and directors entered into a support agreement with the Company and CERo (the “Sponsor
Support Agreement”). Under the Sponsor Support Agreement, the Sponsor agreed to vote, at any meeting of the stockholders of the
Company and in any action by written consent of the stockholders of the Company, all of its shares of Class B common stock (together
with any other equity securities of the Company that it holds of record or beneficially, as of the date of the Sponsor Support Agreement,
or of which it acquires record or beneficial ownership after the date thereof, the “Subject Company Shares”) (i) in favor
of (a) the Business Combination Agreement and the transactions contemplated thereby and (b) the other proposals that the Company
and CERo agreed in the Business Combination Agreement shall be submitted at such meeting for approval by the Company’s stockholders
(together with the proposal to obtain the Company Stockholder Approval, the “Required Transaction Proposals”) and (ii) against
any proposal that conflicts or materially impedes or interferes with any Required Transaction Proposals or that would adversely affect
or delay the Business Combination. The Sponsor Support Agreement also prohibits the Sponsor from, among other things and subject to certain
exceptions, transferring any Subject Company Shares held by the Sponsor or taking any action that would have the effect of preventing
or materially delaying the Sponsor from performing its obligations under the Sponsor Support Agreement, until the earlier of the Closing
or the termination of the Sponsor Support Agreement according to its terms. On July 3, 2023, the Sponsor delivered notice of conversion
of an aggregate of 4,596,250 shares of Class B common stock into an equal number of shares of Class A common stock. Following the Conversion,
the Sponsor held an aggregate of 5,296,246 shares of Class A common stock, all of which are subject to the Sponsor Support Agreement.
CERo
Support Agreements
In
connection with the execution of the Business Combination Agreement, certain CERo stockholders (the “CERo Supporting Stockholders”)
entered into support agreements with CERo (the “CERo Support Agreements”). Under the CERo Support Agreements, each CERo Supporting
Stockholder agreed as promptly as practicable following the time at which the Registration Statement/Proxy Statement shall have been
declared effective and made available to such CERo Supporting Stockholders, to execute and deliver a written consent with respect to
all outstanding shares of CERo common stock and CERo preferred stock held by such CERo Supporting Stockholder (the “Subject CERo
Shares”) approving the Business Combination Agreement and the transactions contemplated thereby (including the Business Combination).
In addition to the foregoing, each CERo Supporting Stockholder agreed that, at any meeting of the holders of CERo capital stock, each
such CERo Supporting Stockholder will appear at the meeting, in person or by proxy, and cause its Subject CERo Shares to be counted as
present thereat for purposes of calculating a quorum and voted (i) to approve and adopt the Business Combination Agreement, the
transactions contemplated thereby (including the Business Combination), and any other matters necessary or reasonably requested by CERo
for consummation of the Business Combination, and (ii) against any proposal that conflicts or materially impedes or interferes with,
or would adversely affect or delay, the consummation of the transactions contemplated by the Business Combination Agreement (including
the Business Combination).
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- DefinitionThe entire disclosure for commitments and contingencies.
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v3.24.1
Stockholders' Deficit
|
12 Months Ended |
Dec. 31, 2023 |
Stockholders’ Deficit [Abstract] |
|
Stockholders’ Deficit |
Note
7 — Stockholders’ Deficit
Common
Stock
Class A
common stock — The Company is authorized to issue 60,000,000 shares of Class A common stock with a par value of $0.0001
per share. As of December 31, 2023 and 2022, there were 5,481,250 and 885,000 shares of Class A common stock issued and outstanding
(excluding 764,957 and 1,288,298 shares subject to possible redemption), respectively.
Class B
common stock — The Company is authorized to issue 10,000,000 shares of Class B common stock with a par value of $0.0001
per share. Holders of Class B common stock are entitled to one vote for each share. On July 3, 2023, the Sponsor delivered notice
of conversion of an aggregate of 4,596,250 shares of Class B common stock into an equal number of shares of Class A common stock. As
of December 31, 2023 and 2022, there were 0 and 4,596,250 shares of Class B common stock issued and outstanding.
Prior
to the consummation of an initial business combination, only holders of shares of Class B common stock will have the right to vote
on the election of directors. Holders of shares of Class A common stock and shares of Class B common stock will vote together
as a single class on all other matters submitted to a vote of stockholders. Preferred
stock — The Company is authorized to issue 1,000,000 shares of preferred stock with such designations,
voting and other rights and preferences as may be determined from time to time by the Company’s board of directors. As of December
31, 2023 and 2022, there were no shares of preferred stock issued or outstanding.
Warrants
— At December 31, 2023 and 2022, there were 8,750,000 Public Warrants and 442,500 Private Placement Warrants
outstanding. The Public Warrants will become exercisable 30 days after the completion of a business combination. No warrants
will be exercisable for cash unless the Company has an effective and current registration statement covering the common stock
issuable upon exercise of the warrants and a current prospectus relating to such common stock.
Notwithstanding
the foregoing, if a registration statement covering the common stock issuable upon exercise of the Public Warrants is not effective within
a specified period following the consummation of a business combination, warrant holders may, until such time as there is an effective
registration statement and during any period when the Company shall have failed to maintain an effective registration statement, exercise
warrants on a cashless basis pursuant to the exemption provided by Section 3(a)(9) of the Securities Act, provided that such exemption
is available. If that exemption, or another exemption, is not available, holders will not be able to exercise their warrants on a cashless
basis. The Public Warrants will expire five years after the completion of a business combination or earlier upon redemption or liquidation.
Once
the warrants become exercisable, the Company may redeem the Public Warrants:
| ● | in
whole and not in part; |
| ● | at a price of $0.01 per warrant; |
| ● | upon not less than 30 days’ prior written notice of redemption; |
| ● | if, and only if, the reported last sale price of Class A common stock equals or exceeds $18.00 per share (as adjusted for stock splits, stock dividends, reorganizations and recapitalizations), for any 20 trading days within a 30-trading-day period commencing at any time after the warrants become exercisable and ending on the third business day prior to the notice of redemption to warrant holders; and |
| ● | if,
and only if, there is a current registration statement in effect with respect to the shares
of Class A common stock underlying the warrants. |
If
the Company calls the Public Warrants for redemption, management will have the option to require all holders that wish to exercise the
Public Warrants to do so on a “cashless basis,” as described in the warrant agreement.
The
Private Placement Warrants are identical to the Public Warrants underlying the Units sold in the IPO, except that the Private Placement
Warrants and the common stock issuable upon the exercise of the Private Placement Warrants will not be transferable, assignable, or salable
until after the completion of a business combination, subject to certain limited exceptions. The Private Placement Warrants will be redeemable
by the Company and exercisable by such holders on the same basis as the Public Warrants.
The
exercise price and number of shares of common stock issuable upon exercise of the warrants may be adjusted in certain circumstances including
in the event of a stock dividend, extraordinary dividend or recapitalization, reorganization, merger, or consolidation. However, the
warrants will not be adjusted for issuances of common stock at a price below their respective exercise prices, other than as set forth
below. Additionally, in no event will the Company be required to net cash settle the warrants. If the Company is unable to complete a
business combination within the Combination Period and the Company liquidates the funds held in the Trust Account, holders of warrants
will not receive any of such funds with respect to their warrants, nor will they receive any distribution from the Company’s assets
held outside of the Trust Account with respect to such warrants. Accordingly, the warrants may expire worthless.
In
addition, if the Company issues additional common stock or equity-linked securities for capital raising purposes in connection with the
closing of a business combination at an issue price or effective issue price of less than $9.20 per share of common stock (with such
issue price or effective issue price to be determined in good faith by the Company’s board of directors, and in the case of any
such issuance to the Initial Stockholders or their affiliates, without taking into account any Founder Shares held by them prior to such
issuance) (the “Newly Issued Price”), and (y) the aggregate gross proceeds from such issuances represent more than 60%
of the total equity proceeds, and interest thereon, available for the funding of a business combination on the date of the consummation
of a business combination (net of redemptions), and (z) the volume weighted-average trading price of the Company’s common
stock during the 20-trading-day period starting on the trading day prior to the day on which the Company consummates a business
combination (such price, the “Market Value”) is below $9.20 per share, the exercise price of the warrants will be adjusted
(to the nearest cent) to be equal to 115% of the greater of (i) the Market Value or (ii) the Newly Issued Price, and the $18.00
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- DefinitionThe entire disclosure for equity.
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v3.24.1
Fair Value Measurements
|
12 Months Ended |
Dec. 31, 2023 |
Fair Value Measurements [Abstract] |
|
Fair Value Measurements |
Note
8 — Fair Value Measurements
The
fair value of the Company’s financial assets and liabilities reflects management’s estimate of amounts that the Company would
have received in connection with the sale of the assets or paid in connection with the transfer of the liabilities in an orderly transaction
between market participants at the measurement date. In connection with measuring the fair value of its assets and liabilities, the Company
seeks to maximize the use of observable inputs (market data obtained from independent sources) and to minimize the use of unobservable
inputs (internal assumptions about how market participants would price assets and liabilities). The following fair value hierarchy is
used to classify assets and liabilities based on the observable inputs and unobservable inputs used in order to value the assets and
liabilities:
Level 1:
Quoted prices in active markets for identical assets or liabilities. An active market for an asset or liability is a market in which
transactions for the asset or liability occur with sufficient frequency and volume to provide pricing information on an ongoing basis.
Level 2:
Observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar
assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.
Level 3:
Unobservable inputs based on the Company’s assessment of the assumptions that market participants would use in pricing the asset
or liability.
At
December 31, 2023, the assets held in the Trust Account were held in money market funds. All of the Company’s investments held
in the Trust Account are classified as trading securities.
The
following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring
basis at December 31, 2023, and indicates the fair value hierarchy of the valuation inputs the Company utilized to determine such fair
value. At December 31, 2022 there were no assets or liabilities measured at fair value.
December
31, 2023
| |
Level | | |
Quoted
Prices in Active Markets (Level 1) | | |
Significant
Other Observable Inputs (Level 2) | | |
Significant
Other Unobservable Inputs (Level 3) | |
Assets: | |
| | |
| | |
| | |
| |
Money
Market Funds | |
| 1 | | |
$ | 8,436,311 | | |
| — | | |
| — | |
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v3.24.1
Subsequent Events
|
12 Months Ended |
Dec. 31, 2023 |
Subsequent Events [Abstract] |
|
Subsequent Events |
Note
9 — Subsequent Events
The
Company evaluated subsequent events and transactions that occurred up to the date the financial statements were issued. Based upon this
review, other than described below, the Company did not identify any other subsequent events that would have required adjustment or disclosure
in the financial statements.
On January 3, 2024, the Company held a special meeting of stockholders
(the “Third Special Meeting”). At the Third Special Meeting, the Company’s stockholders approved an amendment (the “Third
IMTA Amendment”) to the IMTA, as amended by the First IMTA Amendment and the Second IMTA Amendment, and an amendment (the “Third
Charter Amendment”) to the Charter, as amended by the First Charter Amendment and the Second Charter Amendment, to extend the business
combination period up to three times for one month each time (the “Third Extension”).
In connection with the approval
of the Third Extension, the Sponsor deposited $22,600 in the Trust Account, and holders of 11,625 Public Shares exercised redemption
rights requiring the Company to make a series of payments of an aggregate of $128,133 for an aggregate $11.02 per redeemed share. As
a result, following satisfaction of such redemptions, the Company had 6,234,582 shares of Class A common stock outstanding, of which
(i) 753,332 were Public Shares, which were entitled to receive a pro rata portion of the remaining funds in the Company’s Trust
Account in connection with its initial Business Combination, a liquidation or certain other events, (ii) 4,596,250 were Class A common
stock issued upon the conversion of an equal number of shares of the Class B common stock, which did not have redemption rights, and
(iii) 885,000 were Private Placement Shares, which did not have redemption rights. As a result of the deposit described above, such payments
and accrual of interest, the balance in the trust account as of the last extension payment was approximately $8.4 million. Business Combination
On
February 5, 2024, the parties entered into Amendment No. 1 to the Business Combination Agreement to, among other things, (i) remove the
minimum cash condition, (ii) modify the stock-price based milestones such that (a) the trading price condition for the First Level Earnout
Target shall be reset from $12.50 to 125% of the reset Conversion Price of the Series A Preferred Stock and (b) the trading price condition
for the Second Level Earnout Target shall be reset from $15.00 to 150% of the reset Conversion Price of the Series A Preferred Stock,
and (iii) increase the aggregate number of shares of Class A common stock issuable to the stockholders of CERo in connection with the
Business Combination from 4,651,704 shares to 5,000,000 shares. Such number of shares is in addition to up to 1,200,000 shares issuable
upon satisfaction of certain earn-out conditions and 382,651 shares issuable upon exercise of rollover options or warrants.
On February 8, 2024, the Company held a special meeting of stockholders
(the “Fourth Special Meeting”). At the Fourth Special Meeting, the Company’s stockholders adopted and approved (i) the
Business Combination Agreement, pursuant to which Merger Sub merged with and into CERo, with CERo surviving as a wholly-owned subsidiary
of the Company and approved the Business Combination and the other transactions and ancillary documents contemplated by and required for
the Business Combination; (ii) on a non-binding advisory basis, certain changes to the Charter, including the name change to CERo Therapeutics
Holdings, Inc., share authorizations, and others; (iii) the issuance of Class A common stock to CERo stockholders pursuant to the Business
Combination Agreement; (iv) the election of five directors; and (v) the 2024 Equity Incentive Plan and the 2024 Employee Stock Purchase
Plan, contingent of the consummation of the Business Combination.
In connection with the approval of the Business Combination, holders
of 671,285 shares of Class A common stock, exercised redemption rights. As a result, following satisfaction of such redemptions, we had
5,563,297 shares of Class A common stock outstanding, of which (i) 82,047 were shares of Class A common stock issued to the public in
our IPO, which shares of Class A common stock were entitled to receive a pro rata portion of the remaining funds in our Trust Account
in connection with its initial business combination, a liquidation or certain other events, (ii) 4,596,250 were shares of Class A common
stock issued upon the conversion of an equal number of shares of our Class B common stock acquired by Sponsor prior to our IPO, which
shares of Class A common stock did not have redemption rights, and (iii) 885,000 were shares of Class A common stock included in the private
placement units acquired in the private placement by the Sponsor and other investors concurrent with our IPO, which shares of Class A
common stock did not have redemption rights. On February 14, 2024, we made a series of payments of an aggregate of $7,456,463.30 to holders
of redeemed Class A common stock (an aggregate of $11.11 per redeemed share).
On February 13, 2024, the parties entered into Amendment No. 2 to the
Business Combination Agreement to create two additional pools of earnout shares of Class A common stock, one pool of which contained 875,000
shares, which were fully vested at closing of the Business Combination and which were issued as an offset to the agreement by Sponsor
to forfeit an offsetting number of shares, and one pool of which will contain 1,000,000 shares, which will be fully vested upon the achievement
of certain regulatory milestone-based earnout targets and make certain other technical changes to the timing and process for issuance
of the 1,200,000 shares of Class A common stock subject to the other earn-out conditions set forth in the Business Combination Agreement.
The
Business Combination closed on February 14, 2024, at which time the following occurred:
1.
Each outstanding share of the Company’s preferred stock was converted into the number of shares of Class A common stock
calculated by dividing the liquidation preference by $10.00.
2. Each outstanding
share of the Company’s common stock was converted into the number of shares of Class A common stock calculated by multiplying
each share by the Exchange Ratio. The Exchange Ratio of 0.064452 was calculated by first subtracting the aggregate liquidation
preference of outstanding preferred shares from $50 million, then dividing the result by the number of shares of the Company’s
common stock outstanding and dividing by $10.00 per share.
3. Each holder of the Company’s
common stock received a pro rata portion of up to 1.2 million Earnout Shares, 1,000,000 of which are subject to vesting upon the achievement
of certain stock price-based earnout targets and 200,000 of which are subject to vesting upon a change of control, respectively.
4. Certain holders of the
Company’s common stock received a pro rata portion of 875,000 Earnout Shares, which became fully vested upon the closing of the
Business Combination.
5. Certain holders of the
Company’s common stock received a pro rata portion of up to 1.0 million Earnout Shares, which are subject to vesting upon the Company’s
filing an investigational new drug application (“IND”) with the FDA.
6. Each outstanding Company
option was converted into an option to purchase a number of shares of Class A common stock, equal to the Company’s common shares
underlying the option multiplied by the Exchange Ratio, at an exercise price per share equal to the Company option exercise price divided
by the Exchange Ratio.
7. Each warrant to purchase
CERo preferred stock was converted into a warrant to acquire a number of shares of Class A common stock obtained by dividing the warrant
as-if-exercised liquidation preference by $10.00, with the exercise price equal to the total CERo warrant exercise amount divided by the
number of shares of Class A common stock issuable upon exercise.
8. The CERo Notes automatically converted into shares of Series A Preferred
Stock. PIPE
Financing
In February 2024, New CERo consummated a private placement of 10,080
shares of New CERo Series A Preferred Stock, par value $0.0001 per share (the “Series A Preferred Stock”), warrants to purchase
612,746 shares of Common Stock (the “Common Warrants”) and warrants to purchase 2,500 shares of Series A Preferred Stock (the
“Preferred Warrants” and, together with the Common Warrants, the “PIPE Warrants”), pursuant to the Amended and
Restated Securities Purchase Agreement, dated February 14, 2024, by and among the Company, CERo and certain accredited investors (the
“Initial Investors”) for aggregate cash proceeds to New CERo of approximately $9.98 million. In April 2024, New CERo consummated
a private placement of 626 shares of Series B convertible preferred stock, par value $0.0001 per share (“Series B Preferred Stock”),
pursuant to the Securities Purchase Agreement, dated March 28, 2024, by and among New CERo and certain accredited investors (the “Additional
Investors” and, together with the Initial Investors, the “PIPE Investors”), for aggregate cash proceeds to New CERo
of approximately $0.5 million. A portion of such Series A Preferred Stock was issued as consideration for the cancellation of outstanding
indebtedness or securities of the Company or CERo, including a promissory note of the Company and certain convertible bridge notes of
CERo. Such transactions collectively are referred to as the “PIPE Financing.”
In connection with the PIPE
Financing, New CERo entered into the PIPE Registration Rights Agreements with the PIPE Investors. The terms of the PIPE Registration Rights
Agreements require New CERo to register the number of shares of common stock, par value $0.0001 per share (“Common Stock”)
equal to the sum of (i) 200% of the maximum number of Common Stock issuable upon conversion of the Series A Preferred Stock and Series
B Preferred Stock (assuming for purposes hereof that (w) all the Preferred Warrants have been exercised in full, (x) the Series A Preferred
Stock and Series B Preferred Stock is convertible at the Alternate Conversion Price (as defined in the Series A Certificate of Designations
and Series B Certificate of Designations) assuming an Alternate Conversion Date (as defined in the Series A Certificate of Designations
and Series B Certificate of Designations) of such date of determination, and (y) any such conversion shall not take into account any limitations
on the conversion of the Series A Preferred Stock and Series B Preferred Stock set forth in the Series A Certificate of Designations and
the Series B Certificate of Conversions, respectively) and (ii) the maximum number of Warrant Common Shares issuable upon exercise of
the Common Warrants (without taking into account any limitations on the exercise of the Common Warrants set forth therein). In addition,
New CERo entered into a side letter with Keystone, pursuant to which New CERo agreed to make a payment of $1.0 million to Keystone, which
amount reflects an original issue discount to Keystone, and to reimburse $150,000 of legal expenses incurred thereby. Additionally, the
Company entered into a share reallocation agreement (the “Share Reallocation Agreement”) with the Sponsor and an institutional
investor party thereto (a “Share Reallocation Investor”). Under the Share Reallocation Agreement, (i) the Share Reallocation
Investor agreed to purchase an aggregate of 1,500 shares of Series A Preferred Stock for an aggregate purchase price of $1.5 million in
accordance with the Securities Purchase Agreement, and (ii) the Sponsor agreed to forfeit an aggregate of 250,000 shares of Class A Common
Stock held by the Sponsor for no additional consideration other than the commitments and undertakings of the Share Reallocation Investor
made to the Company, in each case, on or promptly following the consummation of the Business Combination at the Closing.
Fee
Modification
Prior
to the close of the Business Combination, the Company entered into fee modification agreements with certain third-party vendors and service
providers, pursuant to which such vendors received an aggregate of 1,629,500 shares of Common Stock in lieu of certain payments due to
such vendors. As a result, the cash expenses payable at Closing were reduced by approximately $8.54 million.
In
particular, the Company entered into a fee modification agreement with CCM, pursuant to which CCM forfeited such fees and the Company
issued an aggregate of 1,200,000 shares of Common Stock, with 1,000,000 of such shares being subject to forfeiture unless New CERo conducts
a capital-raising transaction within nine months of the Closing, pursuant to which New CERo shall issue and sell securities in an aggregate
amount of at least $25.0 million, Affiliates of CCM have and manage investment vehicles with a passive investment in the Sponsor.
Equity
Line of Credit – Keystone Capital Partners, LLC (“Keystone”)
On February 14, 2024, as a condition to the closing of the PIPE Financing,
New CERo entered into a common stock purchase agreement (the “Common Stock Purchase Agreement”) with Keystone, pursuant to
which New CERo may sell and issue, and Keystone is obligated to purchase, up to the lesser of (i) an aggregate of up to 2,977,070 shares
of newly issued shares of Common Stock and (ii) the Exchange Cap (as defined below). As consideration for
Keystone’s commitment to purchase shares of Common Stock pursuant to the Common Stock Purchase Agreement, at Closing, New CERo
issued 119,050 shares of Common Stock to Keystone. In addition, New CERo has agreed to issue an additional $250,000 of shares of
Common Stock to Keystone at each of the 90- and 180-day anniversaries of the effectiveness of the registration statement on Form S-1
with respect to the resale of the shares issuable pursuant to the Common Stock Purchase Agreement, with the number of such shares
determined based upon the average of the daily VWAP (as defined below) for each of the five trading days immediately prior to such
90- or 180-day anniversary.
New
CERo does not have a right to commence any sales of Common Stock to the Investor under the Common Stock Purchase Agreement until the
time when all of the conditions to the New CERo’s right to commence sales of Common Stock to the Investor set forth in the Common
Stock Purchase Agreement have been satisfied, including that a registration statement covering the resale of such shares is declared
effective by the SEC and the final form of prospectus contained therein is filed with the SEC (the “Commencement Date”).
Over the 36-month period from and after the Commencement Date, New CERo will control the timing and amount of any sales of Common Stock
to Keystone. Actual sales of shares of Common Stock to Keystone under the Common Stock Purchase Agreement will depend on a variety of
factors to be determined by New CERo from time to time, including, among others, market conditions, the trading price of the Common Stock
and determinations by the Company as to the appropriate sources of funding and New CERo’s operations.
At
any time from and after the Commencement Date, on any business day on which the closing sale price of the Common Stock is equal to or
greater than $1.00 (the “Purchase Date”), New CERo may direct Keystone to purchase a specified number of shares of Common
Stock (a “Fixed Purchase”) not to exceed 10,000 shares at a purchase price equal to the lesser of 90% of (i) the daily volume
weighted average price (the “VWAP”) of the Common Stock for the five trading days immediately preceding the applicable Purchase
Date for such Fixed Purchase and (ii) the closing price of a share of Common Stock on the applicable Purchase Date for such Fixed Purchase
during the full trading day on such applicable Purchase Date.
In
addition, at any time from and after the Commencement Date, on any business day on which the closing sale price of the Common Stock is
equal to or greater than $1.00 and such business day is also the Purchase Date for a Fixed Purchase of the maximum allowable amount of
shares of Common Stock (the “VWAP Purchase Date”), New CERo may also direct Keystone to purchase, on the immediately following
business day, an additional number of shares of Common Stock in an amount up to a defined limit at a purchase price equal to the lesser
of 90% of (i) the closing sale price of the Common Stock on the applicable VWAP Purchase Date and (ii) the VWAP during the VWAP Purchase
Date between the opening of trading and the purchase termination time. At any time from and after the Commencement Date, on any business
day that is also the VWAP Purchase Date for a VWAP Purchase, New CERo may also direct Keystone to purchase, on such same business day,
an additional number of shares of Common Stock in an amount up to a defined limit (an “Additional VWAP Purchase”) at a purchase
price equal to the lesser of 90% of (i) the closing sale price of the Common Stock on the applicable Additional VWAP Purchase Date and
(ii) the VWAP during the measurement time on the Additional VWAP Purchase Date.
In
no event shall New CERo issue to Keystone under the Common Stock Purchase Agreement more than 19.99% of the total number of shares of
Common Stock outstanding immediately prior to the execution of the Common Stock Purchase Agreement (the “Exchange Cap”),
unless (i) the Company obtains the approval of the issuance of such shares by its stockholders in accordance with the applicable stock
exchange rules or (ii) sales of Common Stock are made at a price equal to or in excess of the lower of (A) the closing price immediately
preceding the delivery of the applicable notice to the Investor and (B) the average of the closing prices of the Common Stock for the
five business days immediately preceding the delivery of such notice (in each case plus an incremental amount to take into account the
Commitment Shares, such that the sales of such Common Stock to Keystone would not count toward the Exchange Cap because they are “at
market” under applicable stock exchange rules.
Concurrent
with the execution of the Common Stock Purchase Agreement, the Company entered into a registration rights agreement with Keystone (the
“ELOC Registration Rights Agreement”), pursuant to which New CERo agreed to provide Keystone with customary registration
rights related to the shares issued under the ELOC Registration Rights Agreement.
Equity
Line of Credit – Arena Business Solutions Global SPC II, Ltd (“Arena”)
On
February 23, 2024, New CERo entered into a purchase agreement (the “Purchase Agreement”) with Arena, under which Arena has
committed to purchase up to $25 million (the “Commitment Amount”) of New CERo’s shares of Common Stock, subject to
the satisfaction of the conditions in the Purchase Agreement. Such
sales of Common Stock, if any, will be subject to certain limitations, and may occur from time to time at New CERo’s sole discretion
over the period commencing on the termination of the Common Stock Purchase Agreement and expiring approximately 36 months following such
termination, provided that a Registration Statement (as defined below) is and remains effective, and the other conditions set forth in
the Purchase Agreement are satisfied. New CERo will control the timing and amount of any sales of Common Stock to Arena. Actual sales
of shares of Common Stock to Arena under the Purchase Agreement will depend on a variety of factors to be determined by New CERo from
time to time, including, among others, market conditions, the trading price of the Common Stock and determinations by the Company as
to the appropriate sources of funding and New CERo’s operations.
On any trading day, New CERo may direct Arena to purchase amounts of
its Common Stock up to the Commitment Amount. The maximum amount that the Company may specify in any one Advance Notice is equal to: (A)
if the Advance Notice is received by 8:30 a.m. Eastern time, then the maximum amount that the Company may specify is equal to the lesser
of (i) an amount equal to 60% of the average Daily Value Traded of the Common Stock on the ten trading days immediately preceding such
Advance Notice, or (ii) $20.0 million; and (B) if the Advance Notice is received after 8:30 a.m. Eastern time but prior to 10:30 a.m.
Eastern time, then the maximum amount that the Company may specify in an Advance Notice is equal to the lesser of: (i) an amount equal
to 30% of the average Daily Value Traded of the Common Stock on the ten trading days immediately preceding such Advance Notice, or (ii)
$15.0 million. For these purposes, “Daily Value Traded” is the product obtained by multiplying the daily trading volume of
New CERo Common Stock on Nasdaq during regular trading hours by the VWAP for that trading day.
Under
the applicable rules of Nasdaq and the Purchase Agreement, New CERo will not sell or issue to Arena shares of Common Stock, inclusive
of the Commitment Fee Shares (as defined below), in excess of the Exchange Cap, unless the Company obtains stockholder approval to issue
shares of Common Stock in excess of the Exchange Cap. In any event, New CERo may not issue or sell any shares of Common Stock under the
Purchase Agreement if such issuance or sale would breach any applicable Nasdaq rules.
The
Purchase Agreement also prohibits the Company from directing Arena to purchase any shares of Common Stock if those shares, when aggregated
with all other shares of Common Stock then beneficially owned by Arena and its affiliates as a result of purchases under the Purchase
Agreement, would result in Arena and its affiliates having beneficial ownership of more than the 4.99% of the then-outstanding Common
Stock.
The
purchase price of the shares of Common Stock will be equal to 90% of the lower of (i) the closing sale price of the Common Stock on the
purchase date (ii) VWAP of the Common Stock during the purchase date and (iii) the arithmetic average of the three lowest closing prices
of the Common Stock during the ten consecutive trading days ending on the trading day immediately preceding the purchase date.
As
consideration for Arena’s irrevocable commitment to purchase Common Stock upon the terms of the Purchase Agreement, New CERo agreed
to issue a number of shares of Common Stock (the “Commitment Fee Shares”) equal to 500,000 divided by the simple average
of the daily VWAP of the Common Stock during the five trading days immediately preceding the effectiveness of the registration statement
with respect to the resale by Keystone of the shares of Common Stock issuable pursuant to the Common Stock Purchase Agreement (the “Registration
Statement”). In addition, New CERo has granted Arena customary registration rights related to the shares issued under the Purchase
Agreement, and has agreed to include the resale by Arena of the Commitment Fee Shares on the Registration Statement.
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v3.24.1
Accounting Policies, by Policy (Policies)
|
12 Months Ended |
Dec. 31, 2023 |
Summary of Significant Accounting Policies [Abstract] |
|
Basis of Presentation |
Basis
of Presentation The
accompanying financial statements are presented in accordance with accounting principles generally accepted in the United States of America
(“GAAP”) and pursuant to the rules and regulations of the SEC.
|
Reclassifications |
Reclassifications Certain
prior year amounts have been reclassified due to an immaterial correction of an error and for consistency with the current period presentation.
These reclassifications had no effect on the reported results of operations. An adjustment for $244,777 has been made to Class A
common stock subject to possible redemption and Accumulated deficit as of December 31, 2022 to correct the total amount redeemable
to stockholders. In the Form 10-Q for three
months ended March 31, 2023, the Company discovered an error in the Statement of Cash Flows for the presentation of restricted cash. The
error was not corrected and persisted in the statements of cash flows in the quarterly reports on 10-Q for the three months ended June
30, 2023 and September 30, 2023. These errors had no impact on the balance sheets or the statements of operations in those periods. This
error is corrected in the statement of cash flows in the Company’s December 31, 2023 audited financial statements.
|
Emerging Growth Company |
Emerging
Growth Company The
Company is an “emerging growth company,” as defined in Section 2(a) of the Securities Act, as modified by the Jumpstart Our
Business Startups Act of 2012 (the “JOBS Act”), and it may take advantage of certain exemptions from various reporting requirements
that are applicable to other public companies that are not emerging growth companies including, but not limited to, not being required
to comply with the independent registered public accounting firm attestation requirements of Section 404 of the Sarbanes-Oxley Act, reduced
disclosure obligations regarding executive compensation in its periodic reports and proxy statements, and exemptions from the requirements
of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously
approved. Further,
Section 102(b)(1) of the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting
standards until private companies (that is, those that have not had a Securities Act registration statement declared effective or do
not have a class of securities registered under the Exchange Act) are required to comply with the new or revised financial accounting
standards. The JOBS Act provides that a company can elect to opt out of the extended transition period and comply with the requirements
that apply to non-emerging growth companies but any such election to opt out is irrevocable. The Company has elected not to opt out of
such extended transition period which means that when a standard is issued or revised and it has different application dates for public
or private companies, the Company, as an emerging growth company, can adopt the new or revised standard at the time private companies
adopt the new or revised standard. This may make comparison of the Company’s financial statements with another public company which
is neither an emerging growth company nor an emerging growth company which has opted out of using the extended transition period difficult
or impossible because of the potential differences in accounting standards used.
|
Use of Estimates |
Use
of Estimates The
preparation of financial statements in conformity with U.S. GAAP requires the Company’s management to make estimates and assumptions
that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the reporting period. Making
estimates requires management to exercise significant judgment. Such estimates may be subject to change as more current information becomes
available and accordingly the actual results could differ significantly from those estimates. It is at least reasonably possible that
the estimate of the effect of a condition, situation or set of circumstances that existed at the date of the financial statements, which
management considered in formulating its estimate, could change in the near term due to one or more future confirming events. Actual
results could differ from those estimates.
|
Cash and Cash Equivalents |
Cash
and Cash Equivalents The
Company considers all short-term investments with an original maturity of three months or less when purchased to be cash equivalents.
The Company did not have any cash equivalents as of December 31, 2023 and 2022.
|
Restricted Cash |
Restricted
Cash The
Company considers all cash to be held for a specific purpose restricted cash. As of December 31, 2023 and 2022, the Company had $0 and
$41,665,974 in restricted cash, respectively. The restricted cash as of December 31, 2022 was intended to satisfy stockholder redemption
payments. The cash and restricted cash balances included in the balance sheets as of December 31, 2023 and 2022, are comprised of
the following:
| |
December 31, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Cash | |
$ | 96,873 | | |
$ | 475,870 | |
Restricted cash | |
| — | | |
| 41,665,974 | |
Total cash and restricted cash | |
$ | 96,873 | | |
$ | 42,141,844 | |
|
Money Market Funds Held in Trust Account |
Money
Market Funds Held in Trust Account At
December 31, 2023, the assets held in Trust Account were held in money market funds that invested in U.S. Treasury securities. At December 31,
2022, substantially all of the assets held in the Trust Account were held as cash. The Company’s investments held in the Trust
Account are classified as trading securities. Trading securities are presented on the balance sheets at fair value at the end of each
reporting period. Gains and losses resulting from the change in fair value of investments held in the Trust Account and interest
earned on marketable securities are included in the accompanying statements of operations. The estimated fair values of investments held
in the Trust Account are determined using available market information.
|
Shareholder Redemption Liability |
Shareholder
Redemption Liability On
December 20, 2022, in connection with the Company’s special meeting held to consider the First Charter Amendment, the Company’s
stockholders redeemed 16,211,702 shares of Class A common stock subject to possible redemption at $10.20 per share redemption
value, plus a pro rata share of interest earned. Of the total amount redeemed, payments for 2,581,004 shares of Class A
common stock totaling $26,481,101 plus a true-up payment of $1,361,646 for a total liability of $27,842,747 were subsequently paid to
redeeming stockholders on January 3, 2023. Therefore, a portion of the total redemption payment has been classified as a stockholder
redemption liability in the accompanying balance sheet as of December 31, 2022.
|
Offering Costs Associated with the IPO |
Offering
Costs Associated with the IPO Offering
costs, including additional underwriting fees associated with the underwriter’s partial exercise of the over-allotment option,
consist principally of legal, accounting, underwriting fees and other costs directly related to the IPO. Offering costs, including those
attributable to the underwriter’s partial exercise of the over-allotment option, amounted to $12,729,318. This amount was charged
to stockholders’ deficit upon the completion of the IPO.
|
Concentration of Credit Risk |
Concentration
of Credit Risk Financial
instruments that potentially subject the Company to concentrations of credit risk consist of cash accounts in a financial institution,
which, at times, may exceed the Federal Deposit Insurance Corporation coverage limit of $250,000. At December 31, 2023 and 2022, the
Company has not experienced losses on these accounts and management believes the Company is not exposed to significant risks on such
accounts.
|
Fair Value of Financial Instruments |
Fair
Value of Financial Instruments The
fair value of the Company’s financial assets and liabilities reflects management’s estimate of amounts that the Company would
have received in connection with the sale of the assets or paid in connection with the transfer of the liabilities in an orderly transaction
between market participants at the measurement date. In connection with measuring the fair value of its assets and liabilities, the Company
seeks to maximize the use of observable inputs (market data obtained from independent sources) and to minimize the use of unobservable
inputs (internal assumptions about how market participants would price assets and liabilities). The following fair value hierarchy is
used to classify assets and liabilities based on the observable inputs and unobservable inputs used in order to value the assets and
liabilities: Level 1:
Quoted prices in active markets for identical assets or liabilities. An active market for an asset or liability is a market in which
transactions for the asset or liability occur with sufficient frequency and volume to provide pricing information on an ongoing basis. Level 2:
Observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar
assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active. Level 3:
Unobservable inputs based on the Company’s assessment of the assumptions that market participants would use in pricing the asset
or liability.
|
Income Taxes |
Income
Taxes The
Company complies with the accounting and reporting requirements of ASC 740, “Income Taxes” (“ASC 740”), which
requires an asset and liability approach to financial accounting and reporting for income taxes. Deferred income tax assets and liabilities
are computed for differences between the financial statement and tax bases of assets and liabilities that will result in future taxable
or deductible amounts, based on enacted tax laws and rates applicable to the periods in which the differences are expected to affect
taxable income. Valuation allowances are established, when necessary, to reduce deferred tax assets to the amount expected to be realized. ASC
740 prescribes a recognition threshold and a measurement attribute for the financial statement recognition and measurement of tax positions
taken or expected to be taken in a tax return. For those benefits to be recognized, a tax position must be more likely than not to be
sustained upon examination by taxing authorities. There were no unrecognized tax benefits as of December 31, 2023 and 2022. The Company
recognizes accrued interest and penalties related to unrecognized tax benefits as income tax expense. No amounts were accrued for the
payment of interest and penalties at December 31, 2023 and 2022. The Company is currently not aware of any issues under review that could
result in significant payments, accruals, or material deviation from its position. The Company is subject to income tax examinations
by major taxing authorities since inception. Deferred
tax liabilities and assets are determined based on the difference between the financial statement and tax basis of assets and liabilities,
using enacted tax rates in effect for the year in which the differences are expected to reverse. Current income taxes are based on the
year’s income taxable for federal and state income tax reporting purposes. Total tax provision may differ from the statutory tax
rates applied to income before provision for income taxes due principally to expenses charged which are not tax deductible. The
total provision benefit for income taxes is comprised of the following:
| |
December 31,
2023 | | |
December 31,
2022 | |
Current expense | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
Deferred tax benefit | |
| — | | |
| — | |
Change
in valuation allowance | |
| — | | |
| — | |
Total
income tax (expense) benefit | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
The
net deferred tax assets in the accompanying balance sheets included the following components:
| |
December 31,
2023 | | |
December 31,
2022 | |
Deferred tax assets | |
$ | 607,516 | | |
$ | 596,692 | |
Deferred tax liabilities | |
| — | | |
| — | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Net
deferred tax assets | |
$ | — | | |
$ | — | |
The
deferred tax assets as of December 31, 2023 and 2022 were comprised of the tax effect of cumulative temporary differences as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
General and administration
expenses before business combination | |
$ | 607,516 | | |
$ | 596,692 | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Total | |
$ | — | | |
$ | — | |
In
assessing the realization of deferred tax assets, management considers whether it is more likely than not that some portion or all of
the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future
taxable income during the periods in which temporary differences representing net future deductible amounts become deductible. Management
considers the scheduled reversal of deferred tax assets, projected future taxable income and tax planning strategies in making this assessment.
For the year ended December 31, 2023 and 2022, the valuation allowance was $607,516 and $596,692, respectively. A
reconciliation of the statutory federal income tax provision (benefit) to the Company’s effective tax rate is as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
Statutory
federal income tax rate | |
| 21.0 | % | |
| 21.0 | % |
State
taxes, net of federal tax benefit | |
| 0.0 | % | |
| 0.0 | % |
Valuation
allowance | |
| (17.33 | )% | |
| 852.7 | % |
Income
tax provision (benefit) | |
| 3.67 | % | |
| 873.7 | % |
|
Class A Common Stock Subject to Possible Redemption |
Class A
Common Stock Subject to Possible Redemption The
Company accounts for its Class A common stock subject to possible redemption in accordance with the guidance in ASC 480. Shares
of Class A common stock subject to mandatory redemption (if any) are classified as a liability instrument and are measured at fair
value. Conditionally redeemable Class A common stock (including Class A common stock that features redemption rights that are within
the control of the holder or subject to redemption upon the occurrence of uncertain events not solely within the Company’s control)
is classified as temporary equity. At all other times, Class A common stock is classified as stockholders’ equity. The Company’s
Class A common stock features certain redemption rights that are considered to be outside of the Company’s control and subject
to occurrence of uncertain future events. Accordingly, at December 31, 2023 and 2022, 764,957 and 1,288,298 shares of Class A common
stock subject to possible redemption are presented as temporary equity, outside of the stockholders’ deficit section of the Company’s
balance sheets. The
Company recognizes changes in redemption value immediately as they occur and adjusts the carrying value of redeemable Class A common
stock to equal the redemption value at the end of each reporting period. Increases or decreases in the carrying amount of redeemable
common stock are affected by charges against additional paid in capital and accumulated deficit. At
December 31, 2023 and 2022, the Class A common stock subject to possible redemption reflected in the balance sheets is reconciled
in the following table:
Class A common stock subject to possible redemption, December 31, 2021 | |
$ | 178,500,000 | |
Plus: Accretion of carrying value to redemption value | |
| 2,662,553 | |
Less: redemption of shares | |
| (167,693,708 | ) |
Class A common stock subject to possible redemption, December 31, 2022 | |
$ | 13,468,845 | |
Less: Redemption | |
| (5,638,880 | ) |
Plus: Accretion of carrying value to redemption value | |
| 606,346 | |
Class A common stock subject to possible redemption, December 31, 2023 | |
$ | 8,436,311 | |
|
Net Loss per Common Stock |
Net
Loss per Common Stock The
Company has two classes of shares, which are referred to as Class A common stock and Class B common stock (the “Class
B common stock” or the “Founder Shares”). Earnings and losses are shared pro rata between the two classes of shares.
Public Warrants (see Note 3) and Private Placement Warrants (see Note 4) to purchase an aggregate of 9,192,500 shares of Class A
common stock at $11.50 per share were issued on October 29, 2021. At December 31, 2023 and December 31, 2022, no Public
Warrants or Private Placement Warrants have been exercised. The 9,192,500 shares of Class A common stock underlying outstanding
Public Warrants and Private Placement Warrants were excluded from diluted net income per share for the year ended December
31, 2023 and 2022 because they are contingently exercisable, and the contingencies have not yet been met. As a result, diluted net income
per common stock is the same as basic net income per common stock for the period. The tables below present a reconciliation of the numerator
and denominator used to compute basic and diluted net income per share for each class of stock.
| |
For
the Year Ended December 31, | |
| |
2023 | | |
2022 | |
| |
Class A
common stock | | |
Class B
Common stock | | |
Class A
common stock | | |
Class B
Common stock | |
Basic and diluted net income per share: | |
| | |
| | |
| | |
| |
Numerator: | |
| | |
| | |
| | |
| |
Allocation
of net income | |
$ | (1,641,020 | ) | |
$ | (895,213 | ) | |
$ | (531,288 | ) | |
$ | (136,448 | ) |
Denominator: | |
| | | |
| | | |
| | | |
| | |
Weighted
average shares outstanding | |
| 4,224,247 | | |
| 2,304,421 | | |
| 17,896,428 | | |
| 4,596,250 | |
Basic and diluted net income per share | |
$ | (0.39 | ) | |
$ | (0.39 | ) | |
$ | (0.03 | ) | |
$ | (0.03 | ) |
|
Accounting for Warrants |
Accounting
for Warrants The
Company accounts for warrants as either equity-classified or liability-classified instruments based on an assessment of the instruments’
specific terms and applicable authoritative guidance in ASC 480 and ASC 815, Derivatives and Hedging. The assessment considers
whether the instruments are free standing financial instruments pursuant to ASC 480, meet the definition of a liability pursuant to ASC
480, and whether the instruments meet all of the requirements for equity classification under ASC 815, including whether the instruments
are indexed to the Company’s own common stock and whether the instrument holders could potentially require “net cash settlement”
in a circumstance outside of the Company’s control, among other conditions for equity classification. This assessment, which requires
the use of professional judgment, was conducted at the time of warrant issuance and as of each subsequent period end date while the instruments
are outstanding. Management has concluded that the Public Warrants and Private Placement Warrants issued pursuant to the warrant agreement
qualify for equity accounting treatment.
|
Recent Accounting Pronouncements |
Recent
Accounting Pronouncements In
December 2023, the FASB issued ASU 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures (ASU 2023-09), which requires
disclosure of incremental income tax information within the rate reconciliation and expanded disclosures of income taxes paid, among
other disclosure requirements. ASU 2023-09 is effective for fiscal years beginning after December 15, 2024. Early adoption is permitted.
The Company’s management does not believe the adoption of ASU 2023-09 will have a material impact on its consolidated financial statements
and disclosures. Management
does not believe that any other recently issued, but not yet effective, accounting standards if currently adopted would have a material
effect on the accompanying unaudited condensed financial statements.
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v3.24.1
Summary of Significant Accounting Policies (Tables)
|
12 Months Ended |
Dec. 31, 2023 |
Summary of Significant Accounting Policies [Abstract] |
|
Schedule of Cash and Restricted Cash |
The cash and restricted cash balances included in the balance sheets as of December 31, 2023 and 2022, are comprised of
the following:
| |
December 31, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Cash | |
$ | 96,873 | | |
$ | 475,870 | |
Restricted cash | |
| — | | |
| 41,665,974 | |
Total cash and restricted cash | |
$ | 96,873 | | |
$ | 42,141,844 | |
|
Schedule of Total Provision (Benefit) For Income Taxes |
The
total provision benefit for income taxes is comprised of the following:
| |
December 31,
2023 | | |
December 31,
2022 | |
Current expense | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
Deferred tax benefit | |
| — | | |
| — | |
Change
in valuation allowance | |
| — | | |
| — | |
Total
income tax (expense) benefit | |
$ | (94,819 | ) | |
$ | (599,159 | ) |
|
Schedule of Net Deferred Tax Assets and Liabilities in the Accompanying Balance Sheets |
The
net deferred tax assets in the accompanying balance sheets included the following components:
| |
December 31,
2023 | | |
December 31,
2022 | |
Deferred tax assets | |
$ | 607,516 | | |
$ | 596,692 | |
Deferred tax liabilities | |
| — | | |
| — | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Net
deferred tax assets | |
$ | — | | |
$ | — | |
|
Schedule of Deferred Tax Assets |
The
deferred tax assets as of December 31, 2023 and 2022 were comprised of the tax effect of cumulative temporary differences as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
General and administration
expenses before business combination | |
$ | 607,516 | | |
$ | 596,692 | |
Valuation
allowance for deferred tax assets | |
| (607,516 | ) | |
| (596,692 | ) |
Total | |
$ | — | | |
$ | — | |
|
Schedule of Reconciliation of the Statutory Federal Income Tax Provision (Benefit) to the Company’s Effective Tax Rate |
A
reconciliation of the statutory federal income tax provision (benefit) to the Company’s effective tax rate is as follows:
| |
December 31,
2023 | | |
December 31,
2022 | |
Statutory
federal income tax rate | |
| 21.0 | % | |
| 21.0 | % |
State
taxes, net of federal tax benefit | |
| 0.0 | % | |
| 0.0 | % |
Valuation
allowance | |
| (17.33 | )% | |
| 852.7 | % |
Income
tax provision (benefit) | |
| 3.67 | % | |
| 873.7 | % |
|
Schedule of Class A Common Stock Subject to Possible Redemption |
At
December 31, 2023 and 2022, the Class A common stock subject to possible redemption reflected in the balance sheets is reconciled
in the following table:
Class A common stock subject to possible redemption, December 31, 2021 | |
$ | 178,500,000 | |
Plus: Accretion of carrying value to redemption value | |
| 2,662,553 | |
Less: redemption of shares | |
| (167,693,708 | ) |
Class A common stock subject to possible redemption, December 31, 2022 | |
$ | 13,468,845 | |
Less: Redemption | |
| (5,638,880 | ) |
Plus: Accretion of carrying value to redemption value | |
| 606,346 | |
Class A common stock subject to possible redemption, December 31, 2023 | |
$ | 8,436,311 | |
|
Schedule of Basic and Diluted Net Income Per Share |
The tables below present a reconciliation of the numerator
and denominator used to compute basic and diluted net income per share for each class of stock.
| |
For
the Year Ended December 31, | |
| |
2023 | | |
2022 | |
| |
Class A
common stock | | |
Class B
Common stock | | |
Class A
common stock | | |
Class B
Common stock | |
Basic and diluted net income per share: | |
| | |
| | |
| | |
| |
Numerator: | |
| | |
| | |
| | |
| |
Allocation
of net income | |
$ | (1,641,020 | ) | |
$ | (895,213 | ) | |
$ | (531,288 | ) | |
$ | (136,448 | ) |
Denominator: | |
| | | |
| | | |
| | | |
| | |
Weighted
average shares outstanding | |
| 4,224,247 | | |
| 2,304,421 | | |
| 17,896,428 | | |
| 4,596,250 | |
Basic and diluted net income per share | |
$ | (0.39 | ) | |
$ | (0.39 | ) | |
$ | (0.03 | ) | |
$ | (0.03 | ) |
|
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- DefinitionTabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.
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v3.24.1
Fair Value Measurements (Tables)
|
12 Months Ended |
Dec. 31, 2023 |
Fair Value Measurements [Abstract] |
|
Schedule of Assets and Liabilities that are Measured at Fair Value on a Recurring Basis |
The
following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring
basis at December 31, 2023, and indicates the fair value hierarchy of the valuation inputs the Company utilized to determine such fair
value. At December 31, 2022 there were no assets or liabilities measured at fair value.
| |
Level | | |
Quoted
Prices in Active Markets (Level 1) | | |
Significant
Other Observable Inputs (Level 2) | | |
Significant
Other Unobservable Inputs (Level 3) | |
Assets: | |
| | |
| | |
| | |
| |
Money
Market Funds | |
| 1 | | |
$ | 8,436,311 | | |
| — | | |
| — | |
|
X |
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v3.24.1
Description of Organization and Business Operations and Liquidity (Details) - USD ($)
|
|
|
|
|
|
12 Months Ended |
|
|
|
|
|
|
|
|
|
|
|
|
|
Feb. 14, 2024 |
Jul. 17, 2023 |
May 09, 2023 |
Aug. 16, 2022 |
Oct. 08, 2021 |
Oct. 08, 2021 |
Dec. 31, 2023 |
Dec. 31, 2022 |
Feb. 05, 2024 |
Jan. 03, 2024 |
Nov. 30, 2023 |
Oct. 04, 2023 |
Sep. 01, 2023 |
Jul. 28, 2023 |
Jul. 07, 2023 |
Jun. 30, 2023 |
May 08, 2023 |
Apr. 03, 2023 |
Mar. 31, 2023 |
Dec. 20, 2022 |
Oct. 29, 2021 |
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gross proceeds |
|
|
|
|
|
|
$ 8,450,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional units issued during the period shares (in Shares) |
|
|
|
|
|
|
2,200,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Deferred underwriting commissions including fees |
|
|
|
|
|
|
$ 9,150,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
deferred underwriting fees payable |
|
|
|
|
|
|
9,150,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Investment of cash in trust account |
|
|
|
|
|
|
$ 178,500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cash deposited in trust account per unit (in Dollars per share) |
|
|
|
|
|
|
$ 10.2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair value percentage |
|
|
|
|
|
|
80.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Public shares (in Dollars per share) |
|
|
|
|
|
|
$ 10.2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Minimum net worth to consummate business combination |
|
|
|
|
|
|
$ 5,000,001
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Percentage of aggregate share |
|
|
|
|
|
|
20.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Deposit held in trust account |
|
|
|
|
|
|
$ 22,949
|
|
|
|
$ 22,949
|
$ 22,949
|
$ 22,949
|
$ 8,846
|
$ 37,052
|
$ 150,000
|
$ 125,000
|
|
$ 100,000
|
|
|
Payments of accrual interest |
|
|
|
|
|
|
8,400,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Interest to pay dissolution expenses |
|
|
|
|
|
|
$ 100,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Sale of stock price per share (in Dollars per share) |
|
|
|
|
|
|
$ 10.2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Business combination amount |
|
|
|
|
|
|
$ 50,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) |
|
|
|
|
|
|
$ 0.0001
|
$ 0.0001
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Liquidation price per share (in Dollars per share) |
|
|
|
|
|
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Percentage of excise tax |
|
|
|
1.00%
|
|
|
1.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock tendered for redemption shares (in Shares) |
|
523,341
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total redemption amount |
|
$ 5,638,879
|
|
|
|
|
$ 5,638,879
|
$ 181,019,852
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Excise tax liability |
|
|
|
|
|
|
$ 56,389
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Percentage of excise tax liability |
|
|
|
|
|
|
1.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cash at carrying value |
|
|
|
|
|
|
$ 96,873
|
475,870
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Trust account |
|
|
|
|
|
|
8,436,311
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net working capital |
|
|
|
|
|
|
5,049,122
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional federal income tax due |
|
|
$ 182,308
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Accumulated deficit |
|
|
|
|
|
|
$ 14,200,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock traded at a value |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 50,000,000
|
|
|
|
Warrant [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Exercise price per share (in Dollars per share) |
|
|
|
|
|
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
IPO [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Units issued during the period shares (in Shares) |
|
|
|
|
|
15,500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Unit price per share (in Dollars per share) |
|
|
|
|
$ 10
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Proceeds from initial public offering gross |
|
|
|
|
|
$ 155,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Offering costs |
|
|
|
|
|
|
$ 12,729,318
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Underwriting fees |
|
|
|
|
|
|
2,635,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Deferred underwriting commissions including fees |
|
|
|
|
|
|
9,150,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other costs |
|
|
|
|
|
|
$ 944,318
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Public Shares issued |
|
|
|
|
|
|
|
1,288,298
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Sale of stock price per share (in Dollars per share) |
|
|
|
|
|
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Private Placement [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Unit price per share (in Dollars per share) |
|
|
|
|
$ 10
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gross proceeds |
|
|
|
|
$ 8,850,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Public Shares issued |
|
|
|
|
|
|
|
$ 885,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Over-Allotment Option [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Units issued during the period shares (in Shares) |
|
|
|
|
|
|
2,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Unit price per share (in Dollars per share) |
|
|
|
|
$ 10
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gross proceeds |
|
|
|
|
|
|
$ 20,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Underwriting fees |
|
|
|
|
|
|
1,400,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Underwriting fees |
|
|
|
|
|
|
$ 400,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number of shares redemption (in Shares) |
|
|
|
|
|
|
16,211,702
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock outstanding (in Shares) |
|
|
|
|
|
|
|
2,173,298
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Public Shares issued |
|
|
|
|
|
|
$ 547
|
$ 88
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock par value (in Dollars per share) |
|
|
|
|
|
|
$ 0.0001
|
$ 0.0001
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Exercise price per share (in Dollars per share) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 11.5
|
Payments of aggregate |
|
|
|
|
|
|
$ 5,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock outstanding (in Shares) |
|
|
|
|
|
|
5,481,250
|
885,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock issued (in Shares) |
|
|
|
|
|
|
5,481,250
|
885,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Class A Common Stock [Member] | IPO [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Exercise price per share (in Dollars per share) |
|
|
|
|
|
|
$ 11.5
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Class A Common Stock [Member] | Sponsor [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock outstanding (in Shares) |
|
|
|
|
|
|
6,246,207
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock issued (in Shares) |
|
|
|
|
|
|
6,246,207
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CERo common stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock par value (in Dollars per share) |
|
|
|
|
|
|
$ 0.0001
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CERo Preferred Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) |
|
|
|
|
|
|
$ 0.0001
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Class B Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Public Shares issued |
|
|
|
|
|
|
|
$ 459
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock par value (in Dollars per share) |
|
|
|
|
|
|
$ 0.0001
|
$ 0.0001
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock outstanding (in Shares) |
|
|
|
|
|
|
0
|
4,596,250
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock issued (in Shares) |
|
|
|
|
|
|
0
|
4,596,250
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Class B Common Stock [Member] | Sponsor [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock outstanding (in Shares) |
|
|
|
|
|
|
0
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock issued (in Shares) |
|
|
|
|
|
|
0
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Investment Company Act [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ownership percentage |
|
|
|
|
|
|
50.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Unit price per share (in Dollars per share) |
$ 10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gross proceeds |
$ 9,980,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock outstanding (in Shares) |
|
|
|
|
|
|
|
|
|
6,234,582
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Class A Common Stock [Member] | Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock issued (in Shares) |
|
|
|
|
|
|
|
|
4,651,704
|
|
|
|
|
|
|
|
|
|
|
|
|
Business Combination [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Business acquisition, effective date of acquisition |
|
|
|
|
|
|
Jan. 08, 2024
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CERo common stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description of Organization and Business Operations and Liquidity [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Business combination price per share (in Dollars per share) |
|
|
|
|
|
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
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CERo common stock [Member] | Subsequent Event [Member] |
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Description of Organization and Business Operations and Liquidity [Line Items] |
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Business combination price per share (in Dollars per share) |
$ 10
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Sponsor [Member] |
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Description of Organization and Business Operations and Liquidity [Line Items] |
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Maximum borrowing capacity |
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$ 1,500,000
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$ 1,500,000
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Sponsor [Member] | Unsecured Promissory Note [Member] |
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Description of Organization and Business Operations and Liquidity [Line Items] |
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Unsecured promissory note |
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$ 1,500,000
|
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Sponsor [Member] | Private Placement [Member] |
|
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Description of Organization and Business Operations and Liquidity [Line Items] |
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Units issued during the period shares (in Shares) |
|
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|
845,000
|
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Unit price per share (in Dollars per share) |
|
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|
$ 10
|
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Sponsor [Member] | Subsequent Event [Member] |
|
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Description of Organization and Business Operations and Liquidity [Line Items] |
|
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Unit price per share (in Dollars per share) |
|
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|
$ 11.02
|
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Sponsor and Cohen and Company Capital Markets [Member] | Private Placement [Member] |
|
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Description of Organization and Business Operations and Liquidity [Line Items] |
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Gross proceeds |
|
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|
$ 400,000
|
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Additional units issued during the period shares (in Shares) |
|
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|
40,000
|
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Initial Stockholders [Member] |
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Description of Organization and Business Operations and Liquidity [Line Items] |
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Percentage of Public Shares that would not be redeemed if Business Combination is not completed within Initial Combination Period |
|
|
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|
100.00%
|
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v3.24.1
Summary of Significant Accounting Policies (Details) - USD ($)
|
|
|
12 Months Ended |
|
|
Jan. 03, 2023 |
Dec. 20, 2022 |
Dec. 31, 2023 |
Dec. 31, 2022 |
Oct. 29, 2021 |
Summary of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Restricted cash |
|
|
$ 0
|
$ 41,665,974
|
|
Shareholder redemption liability |
|
|
|
27,842,747
|
|
FDIC coverage limit amount |
|
|
250,000
|
|
|
Unrecognized tax benefits |
|
|
|
|
|
Payment of interest and penalties |
|
|
|
|
|
Valuation allowance |
|
|
$ 607,516
|
$ 596,692
|
|
Common stock subject to possible redemption (in Shares) |
|
|
764,957
|
1,288,298
|
|
Over-Allotment Option [Member] |
|
|
|
|
|
Summary of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Offering costs |
|
|
$ 12,729,318
|
|
|
Class A Common Stock [Member] |
|
|
|
|
|
Summary of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Accumulated deficit |
|
|
$ 244,777
|
|
|
Number of shares redeemed (in Shares) |
2,581,004
|
16,211,702
|
|
|
|
Subject to possible redemption per share (in Dollars per share) |
|
$ 10.2
|
|
|
|
Class A common stock totaling |
$ 26,481,101
|
|
|
|
|
True-up payment |
1,361,646
|
|
|
|
|
Shareholder redemption liability |
$ 27,842,747
|
|
|
|
|
Purchase of aggregate shares (in Shares) |
|
|
|
|
9,192,500
|
Price per share (in Dollars per share) |
|
|
|
|
$ 11.5
|
Shares of common stock underlying (in Shares) |
|
|
9,192,500
|
|
|
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v3.24.1
v3.24.1
Summary of Significant Accounting Policies (Details) - Schedule of Class A Common Stock Subject to Possible Redemption - USD ($)
|
12 Months Ended |
Dec. 31, 2023 |
Dec. 31, 2022 |
Summary of Reconciliation of Balance Sheet From Common Stock Subject to Possible Redemption to Redemption Value [Abstract] |
|
|
Class A common stock subject to possible redemption, beggining balance |
$ 13,468,845
|
$ 178,500,000
|
Plus: Accretion of carrying value to redemption value |
606,346
|
2,662,553
|
Less: Redemption |
(5,638,880)
|
(167,693,708)
|
Class A common stock subject to possible redemption, ending balance |
$ 8,436,311
|
$ 13,468,845
|
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v3.24.1
Summary of Significant Accounting Policies (Details) - Schedule of Basic and Diluted Net Income Per Share - USD ($)
|
12 Months Ended |
Dec. 31, 2023 |
Dec. 31, 2022 |
Class A Common Stock [Member] |
|
|
Schedule of Basic and Diluted Net Income Per Share [Line Items] |
|
|
Allocation of net income |
$ (1,641,020)
|
$ (531,288)
|
Weighted average shares outstanding |
4,224,247
|
17,896,428
|
Basic net income per share |
$ (0.39)
|
$ (0.03)
|
Class B Common Stock [Member] |
|
|
Schedule of Basic and Diluted Net Income Per Share [Line Items] |
|
|
Allocation of net income |
$ (895,213)
|
$ (136,448)
|
Weighted average shares outstanding |
2,304,421
|
4,596,250
|
Basic net income per share |
$ (0.39)
|
$ (0.03)
|
X |
- DefinitionThe amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.
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v3.24.1
Private Placement Warrants (Details) - USD ($)
|
|
12 Months Ended |
Oct. 08, 2021 |
Oct. 08, 2021 |
Dec. 31, 2023 |
Private Placement Warrants (Details) [Line Items] |
|
|
|
Generating gross proceeds (in Dollars) |
|
|
$ 8,450,000
|
Private Placement [Member] |
|
|
|
Private Placement Warrants (Details) [Line Items] |
|
|
|
Shares issued, price per share (in Dollars per share) |
$ 10
|
$ 10
|
|
Generating gross proceeds (in Dollars) |
|
$ 8,850,000
|
|
Class A Common Stock [Member] |
|
|
|
Private Placement Warrants (Details) [Line Items] |
|
|
|
Common stock price per share (in Dollars per share) |
$ 11.5
|
|
|
Cantor Fitzgerald and Co [Member] | Private Placement [Member] |
|
|
|
Private Placement Warrants (Details) [Line Items] |
|
|
|
Purchased shares |
|
155,000
|
|
Cohen and Company Capital Markets [Member] | Private Placement [Member] |
|
|
|
Private Placement Warrants (Details) [Line Items] |
|
|
|
Purchased shares |
|
30,004
|
|
Sponsor and Cohen and Company Capital Markets [Member] | Private Placement [Member] |
|
|
|
Private Placement Warrants (Details) [Line Items] |
|
|
|
Generating gross proceeds (in Dollars) |
|
|
$ 400,000
|
Purchased shares |
|
699,996
|
|
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v3.24.1
Related Party Transactions (Details)
|
|
|
|
1 Months Ended |
12 Months Ended |
|
|
|
|
|
|
Jul. 03, 2023
shares
|
Dec. 20, 2022
$ / shares
|
Sep. 18, 2021
USD ($)
shares
|
Sep. 30, 2021
$ / shares
shares
|
Dec. 31, 2023
USD ($)
$ / shares
shares
|
Dec. 31, 2022
USD ($)
|
Dec. 18, 2023
USD ($)
|
Sep. 12, 2023
USD ($)
|
Jun. 09, 2023
USD ($)
|
May 08, 2023
USD ($)
|
Dec. 13, 2022
USD ($)
|
Jun. 18, 2021
USD ($)
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Sponsor provided funds to pay for certain costs totaling |
|
|
|
|
$ 905,000
|
$ 650,000
|
|
|
|
|
|
|
Number of dividends |
|
|
|
1
|
|
|
|
|
|
|
|
|
Number of trading days |
|
|
|
|
20 days
|
|
|
|
|
|
|
|
Loans under promissory note |
|
|
|
|
$ 1,555,000
|
650,000
|
$ 160,000
|
$ 220,000
|
$ 275,000
|
$ 250,000
|
|
|
Incurred under this agreement |
|
|
|
|
0
|
180,000
|
|
|
|
|
|
|
Fee amount |
|
|
|
|
465,000
|
|
|
|
|
|
|
|
Amount paid |
|
|
|
|
1,162,500
|
|
|
|
|
|
|
|
Sponsor a monthly fee |
|
|
|
|
20,000
|
|
|
|
|
|
|
|
Consulting fees incurred under this agreement |
|
|
|
|
200,000
|
$ 240,000
|
|
|
|
|
|
|
Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Aggregate principal amount |
|
|
|
|
1,500,000
|
|
|
|
|
|
|
|
Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Aggregate principal amount |
|
|
|
|
$ 1,600,000
|
|
|
|
|
|
|
|
Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Consideration for founder shares (in Shares) | shares |
|
|
|
|
9,192,500
|
|
|
|
|
|
|
|
Common stock equals or exceeds per share (in Dollars per share) | $ / shares |
|
$ 10.2
|
|
|
|
|
|
|
|
|
|
|
Founder Shares [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Consideration for founder shares (in Shares) | shares |
|
|
4,598,750
|
|
|
|
|
|
|
|
|
|
Common stock dividends per share (in Dollars per share) | $ / shares |
|
|
|
$ 0.017
|
|
|
|
|
|
|
|
|
Founder Shares [Member] | Over-Allotment Option [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Sponsor forfeited founder shares (in Shares) | shares |
|
|
82,875
|
|
|
|
|
|
|
|
|
|
Sponsor [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Sponsor provided funds to pay for certain costs totaling |
|
|
$ 25,000
|
|
|
|
|
|
|
|
|
|
Founder shares stock dividend (in Shares) | shares |
|
|
|
4,679,125
|
|
|
|
|
|
|
|
|
Monthly consulting fees |
|
|
|
|
$ 15,000
|
|
|
|
|
|
|
|
Sponsor [Member] | Promissory Note [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Aggregate to cover expenses |
|
|
|
|
|
|
|
|
|
|
$ 1,500,000
|
$ 300,000
|
Sponsor [Member] | Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock subject to forfeiture (in Shares) | shares |
|
|
|
|
250,000
|
|
|
|
|
|
|
|
Sponsor [Member] | Founder Shares [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock subject to forfeiture (in Shares) | shares |
|
|
|
|
592,875
|
|
|
|
|
|
|
|
Common stock equals or exceeds per share (in Dollars per share) | $ / shares |
|
|
|
|
$ 12
|
|
|
|
|
|
|
|
Threshold consecutive trading days for transfer, assign or sale of shares or warrants, after the completion of the initial business combination |
|
|
|
|
30 days
|
|
|
|
|
|
|
|
Threshold period after the business combination in which the 20 trading days within any 30 trading day period commences |
|
|
|
|
150 days
|
|
|
|
|
|
|
|
Sponsor [Member] | Founder Shares [Member] | Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Founder shares into an equal number of shares of class A common stock (in Shares) | shares |
4,596,250
|
|
|
|
|
|
|
|
|
|
|
|
Sponsor [Member] | Working Capital Loans [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Aggregate to cover expenses |
|
|
|
|
$ 1,500,000
|
|
|
|
|
|
|
|
Business combination entity at a price per share (in Dollars per share) | $ / shares |
|
|
|
|
$ 10
|
|
|
|
|
|
|
|
Related Party [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Related Party Transactions [Abstract] |
|
|
|
|
|
|
|
|
|
|
|
|
Outstanding balance owed to the sponsor |
|
|
|
|
$ 75,000
|
|
|
|
|
|
|
|
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v3.24.1
Commitments and Contingencies (Details) - USD ($)
|
|
12 Months Ended |
|
|
Oct. 08, 2021 |
Dec. 31, 2023 |
Jul. 03, 2023 |
Dec. 31, 2022 |
Commitments and Contingencies [Line Items] |
|
|
|
|
Reimbursed to pay for additional advisors |
|
$ 465,000
|
|
|
Deferred underwriting commissions, price per unit (in Dollars per share) |
|
$ 0.5
|
|
|
Underwriting commissions |
|
$ 8,750,000
|
|
|
Deferred underwriting commissions including fees |
|
$ 9,150,000
|
|
|
Over-Allotment Option [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Number of units issued (in Shares) |
|
2,000,000
|
|
|
Price per unit (in Dollars per share) |
$ 10
|
|
|
|
Underwriting fees |
|
$ 400,000
|
|
|
IPO [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Number of units issued (in Shares) |
15,500,000
|
|
|
|
Price per unit (in Dollars per share) |
$ 10
|
|
|
|
Underwriting fees |
|
2,635,000
|
|
|
Deferred underwriting commissions including fees |
|
9,150,000
|
|
|
Aggregate amount |
|
$ 400,000
|
|
|
Class A Common Stock [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Common stock shares issued (in Shares) |
|
5,481,250
|
|
885,000
|
Class A Common Stock [Member] | CERo Common Stock [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Common stock shares issued (in Shares) |
|
5,000,000
|
|
|
Class B Common Stock [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Common stock shares issued (in Shares) |
|
0
|
|
4,596,250
|
Class B Common Stock [Member] | CERo Common Stock [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Common stock shares issued (in Shares) |
|
|
4,596,250
|
|
Sponsor Support Agreement [Member] | Class A Common Stock [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Aggregate Shares (in Shares) |
|
5,296,246
|
|
|
Underwriting Agreement [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Underwriting discount, price per unit (in Dollars per share) |
|
$ 0.2
|
|
|
Underwriter cash discount |
|
$ 3,100,000
|
|
|
Underwriting Agreement [Member] | Over-Allotment Option [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Number of units issued (in Shares) |
|
2,325,000
|
|
|
Business Combination Agreement [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
Price per unit (in Dollars per share) |
|
$ 10
|
|
|
Aggregate liquidation preference |
|
$ 50,000,000
|
|
|
Diluted price per share (in Dollars per share) |
|
$ 10
|
|
|
Underwriting Agreement [Member] | Over-Allotment Option [Member] |
|
|
|
|
Commitments and Contingencies [Line Items] |
|
|
|
|
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2,000,000
|
|
|
|
X |
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v3.24.1
Stockholders' Deficit (Details) - $ / shares
|
|
12 Months Ended |
|
Jul. 03, 2023 |
Dec. 31, 2023 |
Dec. 31, 2022 |
Stockholders' Deficit [Line Items] |
|
|
|
Temporary equity, shares |
|
764,957
|
1,288,298
|
Preferred stock shares authorized |
|
1,000,000
|
1,000,000
|
Warrant expire term |
|
5 years
|
|
Number of trading days |
|
30 days
|
|
Price per share (in Dollars per share) |
|
$ 18
|
|
Minimum [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Number of trading days for determining the share price |
|
20 days
|
|
Maximum [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Number of trading days for determining the share price |
|
30 days
|
|
Public Warrants [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Class of warrant or right, outstanding |
|
8,750,000
|
8,750,000
|
Public Warrants [Member] | Warrants and Rights Subject to Mandatory Redemption Trigger Price Exceeds [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Warrant price per share (in Dollars per share) |
|
$ 0.01
|
|
Private Placement Warrants [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Class of warrant or right, outstanding |
|
442,500
|
442,500
|
Class A Common Stock [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Common stock shares authorized |
|
60,000,000
|
60,000,000
|
Common stock par or stated value per share (in Dollars per share) |
|
$ 0.0001
|
$ 0.0001
|
Common stock shares outstanding |
|
5,481,250
|
885,000
|
Common stock shares issued |
|
5,481,250
|
885,000
|
Class A Common Stock [Member] | Public Warrants [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Shares issued price per share (in Dollars per share) |
|
$ 18
|
|
Class A Common Stock [Member] | Public Warrants [Member] | Event Triggering Adjustment to Exercise Price of Warrants [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Shares issued price per share (in Dollars per share) |
|
$ 9.2
|
|
Percentage of total equity proceeds |
|
60.00%
|
|
Market value price per share (in Dollars per share) |
|
$ 9.2
|
|
Adjusted Exercise Price of Warrants Percentage |
|
115.00%
|
|
Class B Common Stock [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Common stock shares authorized |
|
10,000,000
|
10,000,000
|
Common stock par or stated value per share (in Dollars per share) |
|
$ 0.0001
|
$ 0.0001
|
Common stock shares outstanding |
|
0
|
4,596,250
|
Common stock shares issued |
|
0
|
4,596,250
|
Class B Common Stock [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Conversion of aggregate share |
4,596,250
|
|
|
Class B Common Stock [Member] | Class B Common Stock [Member] |
|
|
|
Stockholders' Deficit [Line Items] |
|
|
|
Common Stock Voting Rights |
|
one
|
|
X |
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v3.24.1
X |
- DefinitionThe amount of cash, securities, or other assets held by a third-party trustee pursuant to the terms of an agreement which assets are available to be used by beneficiaries to that agreement only within the specific terms thereof and which agreement is expected to terminate within one year of the balance sheet date (or operating cycle, if longer) at which time the assets held-in-trust will be released or forfeited.
+ ReferencesReference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 235 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(b)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1
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v3.24.1
Subsequent Events (Details)
|
|
|
|
|
|
|
1 Months Ended |
12 Months Ended |
|
|
|
Mar. 31, 2024
USD ($)
$ / shares
|
Feb. 14, 2024
USD ($)
$ / shares
shares
|
Feb. 13, 2024
shares
|
Feb. 05, 2024
$ / shares
shares
|
Jan. 03, 2024
USD ($)
$ / shares
shares
|
Jan. 03, 2023
USD ($)
|
Apr. 30, 2024
shares
|
Feb. 29, 2024
shares
|
Dec. 31, 2023
USD ($)
$ / shares
shares
|
Feb. 23, 2024
USD ($)
|
Dec. 31, 2022
$ / shares
shares
|
Oct. 08, 2021
$ / shares
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Deposit held in trust (in Dollars) | $ |
|
|
|
|
$ 22,600
|
|
|
|
|
|
|
|
Exceed shares of purchase price |
|
|
|
|
|
|
|
|
10,000
|
|
|
|
Purchased shares |
|
|
|
|
|
|
|
|
500,000
|
|
|
|
Redeemed per public share (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 11.03
|
|
$ 10.26
|
|
Convertible preferred stock per share (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 0.0001
|
|
$ 0.0001
|
|
Legal expenses (in Dollars) | $ |
|
|
|
|
|
|
|
|
$ 150,000
|
|
|
|
Aggregate purchase price (in Dollars) | $ |
|
|
|
|
|
|
|
|
1,500,000
|
|
|
|
Cash expenses payable (in Dollars) | $ |
|
|
|
|
|
|
|
|
8,540,000
|
|
|
|
Sell securities (in Dollars) | $ |
|
|
|
|
|
|
|
|
$ 25,000,000
|
|
|
|
Sale price (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 10.2
|
|
|
|
Percentage purchase price |
|
|
|
|
|
|
|
|
90.00%
|
|
|
|
Percentage of common stock outstanding |
|
|
|
|
|
|
|
|
4.99%
|
|
|
|
Average daily value traded of the common stock |
|
|
|
|
|
|
|
|
60.00%
|
|
|
|
Advance Notice (in Dollars) | $ |
|
|
|
|
|
|
|
|
$ 20,000,000
|
|
|
|
Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Purchased shares |
|
|
|
|
|
|
|
|
1,629,500
|
|
|
|
Common stock, par value (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 0.0001
|
|
|
|
Percentage purchase price |
|
|
|
|
|
|
|
|
90.00%
|
|
|
|
Percentage of common stock outstanding |
|
|
|
|
|
|
|
|
19.99%
|
|
|
|
Average daily value traded of the common stock |
|
|
|
|
|
|
|
|
30.00%
|
|
|
|
Advance Notice (in Dollars) | $ |
|
|
|
|
|
|
|
|
$ 15,000,000
|
|
|
|
Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Issued an aggregate |
|
|
|
|
|
|
|
|
1,000,000
|
|
|
|
Keystone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Agreed to make a payment (in Dollars) | $ |
|
|
|
|
|
|
|
|
$ 1,000,000
|
|
|
|
Keystone [Member] | Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Purchased shares |
|
119,050
|
|
|
|
|
|
|
|
|
|
|
Private Placement [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
|
|
|
$ 10
|
Purchased shares |
|
|
|
|
|
|
|
|
885,000
|
|
|
|
IPO [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
|
|
|
$ 10
|
Shares |
|
|
|
|
|
|
|
|
17,500,000
|
|
|
|
Sale price (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 10
|
|
|
|
Volume Weighted Average Price Purchase Date [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Sale price (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 1
|
|
|
|
Percentage purchase price |
|
|
|
|
|
|
|
|
90.00%
|
|
|
|
Additional Volume Weighted Average Price Purchase [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Percentage purchase price |
|
|
|
|
|
|
|
|
90.00%
|
|
|
|
Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock, shares outstanding |
|
|
|
|
|
|
|
|
5,481,250
|
|
885,000
|
|
Common stock, shares issued |
|
|
|
|
|
|
|
|
5,481,250
|
|
885,000
|
|
Number of shares issuable |
|
|
|
|
|
|
|
|
9,192,500
|
|
|
|
Exercised redemption rights (in Dollars) | $ |
|
|
|
|
|
|
|
|
$ 671,285
|
|
|
|
Common stock outstanding |
|
|
|
|
|
|
|
|
5,563,297
|
|
|
|
Exceed shares of purchase price |
|
|
|
|
|
|
|
|
1
|
|
|
|
Conversion of shares |
|
|
|
|
|
|
|
|
4,596,250
|
|
|
|
Redeemed public shares (in Dollars) | $ |
|
|
|
|
|
$ 26,481,101
|
|
|
|
|
|
|
Common stock, par value (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 0.0001
|
|
$ 0.0001
|
|
Class A Common Stock [Member] | Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock issued upon conversion |
|
|
|
|
|
|
|
|
4,596,250
|
|
|
|
Class A Common Stock [Member] | IPO [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Exceed shares of purchase price |
|
|
|
|
|
|
|
|
82,047
|
|
|
|
Series A Preferred Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Purchased shares |
|
|
|
|
|
|
|
|
1,500
|
|
|
|
Common Stock issuable conversion |
|
|
|
|
|
|
|
|
200.00%
|
|
|
|
Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Sale price (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 1
|
|
|
|
Common Stock [Member] | Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Issued an aggregate |
|
|
|
|
|
|
|
|
1,200,000
|
|
|
|
Subsequent Event [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Public shares exercised |
|
|
|
|
11,625
|
|
|
|
|
|
|
|
Payments for Deposits (in Dollars) | $ |
|
|
|
|
$ 128,133
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) | $ / shares |
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
Public shares |
|
|
|
|
753,332
|
|
|
|
|
|
|
|
Accrual of interest in trust account (in Dollars) | $ |
|
|
|
|
$ 8,400,000
|
|
|
|
|
|
|
|
Number of shares issuable |
|
|
|
1,200,000
|
|
|
|
|
|
|
|
|
Shares issuable upon exercise of option or warrants |
|
|
|
382,651
|
|
|
|
|
|
|
|
|
Redeemed public shares (in Dollars) | $ |
|
$ 7,456,463.3
|
|
|
|
|
|
|
|
|
|
|
Redeemed per public share (in Dollars per share) | $ / shares |
|
$ 11.11
|
|
|
|
|
|
|
|
|
|
|
Exchange ratio |
|
0.064452
|
|
|
|
|
|
|
|
|
|
|
Earnout shares |
|
875,000
|
|
|
|
|
|
|
|
|
|
|
Warrants to purchase |
|
|
|
|
|
|
|
612,746
|
|
|
|
|
Aggregate cash proceeds (in Dollars) | $ |
|
$ 9,980,000
|
|
|
|
|
|
|
|
|
|
|
Cash proceeds (in Dollars) | $ |
$ 500,000
|
|
|
|
|
|
|
|
|
|
|
|
Purchase agreement (in Dollars) | $ |
|
|
|
|
|
|
|
|
|
$ 25,000,000
|
|
|
Subsequent Event [Member] | Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Shares of restricted |
|
1,200,000
|
|
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Warrant [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Purchased shares |
|
|
|
|
|
|
|
0.0001
|
|
|
|
|
Subsequent Event [Member] | Private Placement [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Shares |
|
|
|
|
885,000
|
|
|
|
|
|
|
|
Purchased shares |
|
|
|
|
|
|
|
10,080
|
|
|
|
|
Subsequent Event [Member] | Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock, shares outstanding |
|
|
|
|
6,234,582
|
|
|
|
|
|
|
|
Aggregate shares |
|
2,977,070
|
|
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Class A Common Stock [Member] | Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock, shares issued |
|
|
|
4,651,704
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Class A Common Stock [Member] | Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock, shares issued |
|
|
|
5,000,000
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Convertible Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Common stock issued upon conversion |
|
|
|
|
4,596,250
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Series A Preferred Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Warrants to purchase stock |
|
|
|
|
|
|
|
2,500
|
|
|
|
|
Subsequent Event [Member] | Series A Preferred Stock [Member] | Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Conversion price (in Dollars per share) | $ / shares |
|
|
|
$ 12.5
|
|
|
|
|
|
|
|
|
Percentage of conversion price of preferred stock |
|
|
|
125.00%
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Series A Preferred Stock [Member] | Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Conversion price (in Dollars per share) | $ / shares |
|
|
|
$ 15
|
|
|
|
|
|
|
|
|
Percentage of conversion price of preferred stock |
|
|
|
150.00%
|
|
|
|
|
|
|
|
|
Subsequent Event [Member] | Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) | $ / shares |
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
Earnout shares |
|
200,000
|
|
|
|
|
|
|
|
|
|
|
Forecast [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Convertible preferred stock per share (in Dollars per share) | $ / shares |
$ 0.0001
|
|
|
|
|
|
|
|
|
|
|
|
Forecast [Member] | Series B Preferred Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Shares |
|
|
|
|
|
|
626
|
|
|
|
|
|
Second Business Combination Agreement Amendment [Member] | Subsequent Event [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Earnout shares |
|
|
875,000
|
|
|
|
|
|
|
|
|
|
Business Combination Agreement [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 10
|
|
|
|
Business Combination Agreement [Member] | Subsequent Event [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Earnout shares |
|
|
1,000,000
|
|
|
|
|
|
|
|
|
|
Preferred stock value, outstanding (in Dollars) | $ |
|
$ 50,000,000
|
|
|
|
|
|
|
|
|
|
|
Business Combination Agreement [Member] | Subsequent Event [Member] | Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Earnout shares |
|
|
1,200,000
|
|
|
|
|
|
|
|
|
|
CERo Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Per share of liquidation (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
10
|
|
|
|
CERo Common Stock [Member] | Subsequent Event [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Per share of liquidation (in Dollars per share) | $ / shares |
|
$ 10
|
|
|
|
|
|
|
|
|
|
|
Earnout shares |
|
1,000,000
|
|
|
|
|
|
|
|
|
|
|
Business Combination [Member] | Subsequent Event [Member] | Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Shares of restricted |
|
1,000,000
|
|
|
|
|
|
|
|
|
|
|
Sponsor [Member] | Private Placement [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) | $ / shares |
|
|
|
|
|
|
|
|
$ 10
|
|
|
|
Sponsor [Member] | Class A Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Forfeit an aggregate of shares |
|
|
|
|
|
|
|
|
250,000
|
|
|
|
Sponsor [Member] | Subsequent Event [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Price per share (in Dollars per share) | $ / shares |
|
|
|
|
$ 11.02
|
|
|
|
|
|
|
|
Lead Investor [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
Subsequent Events [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
Purchased shares |
|
250,000
|
|
|
|
|
|
|
|
|
|
|
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Phoenix Biotech Aquisition (NASDAQ:PBAXU)
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