PTIL Protherics (MM)

Cheshire, UK , the international biopharmaceutical company focused on critical care and cancer, Protherics PLC announces the grant, on 9 June 2008, of the following options over Ordinary Shares in Protherics ("Ordinary Shares") to Directors and other Persons Discharging Managerial Responsibility (PDMRs) under the terms of the Protherics PLC Long Term Incentive Plan ("LTIP"): Name Position Number of Options Directors: Andrew Heath Chief Executive Officer 500,000 Rolf Soderstrom Finance Director 313,513 James Christie Operations Director 270,270 PDMRs: Ian Scoular Director of Business Development 227,027 Nick Staples Director of Corporate Affairs 191,891 Sally Waterman Director of Research & Development 227,027 The options are exercisable between the third and tenth anniversary of the date of grant at an exercise price of 2p per share, subject to the achievement of performance conditions. Protherics also announces the award, on 9 June 2008, of a conditional right to receive 252,460 Ordinary Shares under the terms of the LTIP, to Saul Komisar, President of the Company's US operations. The award vests on the third anniversary of the date of grant subject to the achievement of performance conditions. In addition to the above, the following Directors and PDMRs were granted options under the terms of the Deferred Bonus Plan on 9 June 2008: Number of Directors: Options Rolf Soderstrom 99,099 James Christie 128,378 PDMRs: Sally Waterman 86,486 Nick Staples 72,972 The options are exercisable between the second and tenth anniversary of the date of grant at an exercise price of 2p per share. Following the above grant of options and share awards, the Company's Directors and PDMRs hold options or share awards over the following number of Ordinary Shares: Number of Shares Andrew Heath 4,523,909 Rolf Soderstrom 1,040,339 James Christie 1,851,986 Saul Komisar 1,523,541 Ian Scoular 1,348,758 Nick Staples 871,114 Sally Waterman 993,023 / Ends / For further information please contact: Protherics Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510 Julie Vickers, Company Secretary +44 (0)1928 518010 Financial Dynamics - press enquiries London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113 New York: John Capodanno, Jonathan Birt +1 212 850 5600 Or visit www.protherics.com This information is provided by RNS The company news service from the London Stock Exchange END

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