CHESHIRE, UK , the international biopharmaceutical company focused on critical care and cancer, announces that the Company's Annual Report and Financial Statements for the year ended 31 March 2008, together with a Circular to Shareholders containing the Notice of the Company's Annual General Meeting to be held at 12.00 noon on Tuesday 22 July 2008 at the offices of Ashurst LLP, Broadwalk House, 5 Appold Street, London EC2A 2HA, have been posted to shareholders today. In accordance with Listing Rule 9.6.1R the following documents have been forwarded to the UK Listing Authority and will shortly be available for inspection at The UK Listing Authority's Document Viewing Facility, which is situated at 25 The North Colonnade, Canary Wharf, London E14 5HS: * Protherics PLC Annual Report and Financial Statements for the year ended 31 March 2008; * Circular to shareholders containing a Notice convening the Company's 2008 Annual General Meeting (the "Meeting") and an explanation of the business to be transacted at the Meeting; * Copies of the Company's Articles of Association which contain amendments to be proposed at the Meeting; * Rules of the Company's new 2008 Savings Related Share Option Scheme, which is to be submitted to shareholders for approval at the Meeting; and * A copy of proposed amendments to the Company's 1996 Unapproved Share Option Scheme, which are to be submitted to shareholders for approval at the Meeting. A copy of the Company's Annual Report and Financial Statements can be accessed on the Company's website at www.protherics.com. / Ends / For further information please contact: Protherics Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510 Julie Vickers, Company Secretary +44 (0)1928 518000 Financial Dynamics - press enquiries London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113 New York: John Capodanno, Jonathan Birt +1 212 850 5600 Or visit www.protherics.com This information is provided by RNS The company news service from the London Stock Exchange END

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