SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 


 

FORM 6-K

 

 

REPORT OF FOREIGN PRIVATE ISSUER

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

 

14 August 2008

 

 

PROTHERICS PLC

(Translation of Registrant’s Name Into English)

 

 

The Heath Business & Technical Park
Runcorn, Cheshire, W47 4QF England

(Address of Principal Executive Offices)

 

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

 

Form 20-F       X              Form 40-F               

 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):             

 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 191(b)(7):             

 

Indicate by check mark whether the registrant by furnishing the information contained in this form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

 

Yes                     No          X     

 

If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82-              .

 

 

The Registrant is furnishing a copy of its announcements as reported to the Company Announcements Office of the London Stock Exchange.

 

 

 

Protherics PLC

Notification of Major Interest in Shares


Lon
don, UK; Brentwood, TN, US; 
14
 August 2008
 -
 Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care an
d cancer, announces 
that
, on 12 August 2008,
 the following notification 
of interest in the ordinary share capital of the Company 
was received 
today
 from Aviva plc
.


1
. Reason for the notification
 
   
 
(please tick the appropriate box or boxes)

An acquisitio
 voting rights 

x
An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to w
hich voting rights are attached


An event changing the breakdown of
 voting rights



Other (please 
s
pecify
): CHANGE TO THE TOTAL NUMBER OF VOTING RIGHTS IN ISSUE


2
. Full name of person(s) subject to the notification obligation:
Aviva plc & its subsidiaries
   
3
. Full name of shareholder(s) 
(if different from 2
.):
Registered Holder:

BNY Norwich Union Nominees Limited  
   

 
6,741,190
*

Chase GA Group Nominees 
Limited  
18,382,959
*

Chase Nominees Limited

979,009
*
   

CUIM Nominee Limited

4,812,551
*

Vida
cos Nominees Limited

70,303
*

BNP Paribas - 
London

636,429


Chase Nominees Limited 

3,518,325

State Street Nominees Limited  

9,577,375

Vidacos Nominees Limited 

2,003
,
920
   
*denotes direct interest  

4
. Date of the transaction (and date on which the threshold is crossed or reached if different):
11
 August 2008
   
5
. Date on which issuer notified:
12
 August 2008
   
6
. Threshold(s) that is/are crossed or reached:
8% to 9
% Change at 
Direct
 Interest level
   

7
. Notified details:





A: Voting rights attached to shares
Class/type of shares 
if possible using the ISIN CODE
Situation previous to the Triggering transaction 
Resulting situation after the triggering transaction
Number of Shares 
Number of Voting Rights 
Number of shares
 
Number of voting rights
% of voting rights
Direct
Direct  
Indirect 
Direct
Indirect
Ordinary Shares

GB0007029209
   

46,151
,
488


4
6,151,488


   

30,986
,
012
   

30,986
,
012
   

15,736
,
049
   

9.06
%
   

4.60
%




B: Financial Instruments
Resulting situation after the triggering transaction 
Type of financial instrument 
Expiration date 
Exercise/ Conversion Period/ Date
 
Number of voting rights that may be acquired if the instrument is exercised/ converted. 
% of voting rights

N/A


Total (A+B)
N
umber of voting rights
% of voting rights
   
4
6,722
,
061
   
13.6
6
%




8
.
 
Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable :
See Section 
3



Proxy Voting:
9
. Name of the proxy holder:
   
See Section 
3
1
0
. Number of voting rights proxy holder will cease to hold:
   
11
. Date on which proxy holder will cease to hold voting rights:
   



12
. Additional information:
Figures are based on a total
 number of voting rights of 3
42
,
159
,
034




                                                                   | Ends |


F
or f
urther 
i
nformation
 please contact
:

Protherics 

Nick Staples
Director of Corporate 
Affairs
+44 (0) 7919 480510  
Julie Vickers, Company Secretary 
+44 (0)
1928 518010


Financial Dynamics
 
- press enquiries

London:
 Ben Atwell, Lara Mott
+44 (0) 20 7831 3113 
New York
:
 John Capodanno
+1 212 850 5600



Or visi
t  
www.protherics.com

This information is provided by RNS
The company news service from the London Stock Exchange
END
 

 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 

       

 

PROTHERICS PLC

       

Date: 14 August 2008

 

By:

 

/s/ Rolf Soderstrom


       

Rolf Soderstrom

       

Finance Director

 

 

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