Protherics PLC


Notification of Major Interests in Shares



London, UK; Brentwood, TN, US: 27 October 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that on 27
October 2008, in accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share capital of
the Company was received from AXA Investment Managers UK Limited on
behalf of AXA S.A. and its Group Companies ("AXA").  Details of the
interest notified are set out below.


The notification follows an increase in the Company's issued ordinary
share capital following the conversion of all outstanding six per cent.
unsecured convertible loan notes 2010 of Protherics, as further
described in the announcement made jointly by Protherics and BTG plc on
18 September 2008.



1.    Reason for the notification (please tick
      the appropriate box or boxes)



An acquisition or disposal of voting rights

An acquisition or disposal of financial
instruments which may result in the acquisition
of shares already issued to which voting rights
are attached


An event changing the breakdown of voting rights


Other (please specify): variation in issued      X
share capital

2. Full name of person(s) subject to the      AXA S.A., 25 Avenue
notification obligation:                      Matignon, 75008 Paris and
                                              its group of companies.

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which 26 October 2008
the threshold is crossed or reached if
different):

5. Date on which issuer notified:             27 October 2008

6. Threshold(s) that is/are crossed or        12%
reached:


7. Notified details:




A: Voting rights attached to shares

Class/   Situation previous to Resulting situation after the triggering
type of  the Triggering                      transaction
shares   transaction
if
possible Number of  Number of  Number of Number of voting   % of voting
using    Shares     Voting     shares    rights               rights
the ISIN            Rights
CODE
                               Direct   Direct    Indirect Direct  Indi-
                                                                  -rect



0702920 42,026,712 42,026,712 1,041,666 1,041,666 40,985,046 0.30%11.70%




B: Financial Instruments

Resulting situation after the triggering transaction

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted.




Total (A+B)

Number of voting rights     % of voting rights


42,026,712                        11.99%



8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :

Name of Company/Fund                    Number of   % of issued share
                                        Shares      capital

AXA                                     716,666     0.20451
Direct


AXA Framlington                         40,985,046  11.69573
Indirect


AXA IM UK                               325,000     0.09274
Direct



Total Direct                            1,041,666   0.29726

Total Indirect                          40,985,046  11.69573


TOTAL                                   42,026,712  11.99298


Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will
cease to hold:

11. Date on which proxy holder will cease to hold
voting    rights:



12. Additional information:





/ Ends /



For further information please contact:


Protherics

Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510

Julie Vickers, Company Secretary            +44 (0)1928 518010


Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113

New York: John Capodanno                    +1 212 850 5600



Or visit  www.protherics.com

                    This information is provided by RNS
          The company news service from the London Stock Exchange

Contacts: RNS Customer Services 0044-207797-4400 Email Contact http://www.rns.com

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