Cassava Sciences Inc (SAVA) Options

What about the director who poured millions into Cassava propping it up when it would crash from bad news? If this was a scam, wouldnt he have known about it?

That also baffled me. Many smart people had their money tied up here and somehow the share price recovered after the court cases in September. Id love to know more about the why.
They didnt see the forest for all the trees?

I can only agree. Shkreli still has friends in the industry that likely told him about all of his "DD" that he presented in this rink dink "paper" then earns the laurels.
98% of PH3 Alzheimer trials miss and this one had many sticks in the soup. --> managements history of lying and no peer reviewed literatue backing.
Unbelievable there is this laughable antihero worshipping around his persona. Nothing fabulous about this sociopath.

I made the same call repeatedly over the last 2 years but didn't get the love that the convicted fraudster is getting!

How long before indictments of former CEO and his wife? Class action suit? Who sold with inside info this past Friday?

I dont like him but he made a good pre P3 call
if somehow it passed P3 it could have went up slot
P3 fail it crashed


Im listening to him talk about shorting MSTR against BTC hedge/arbitrage
https://x.com/i/broadcasts/1LyxBgywQZkKN

Last call all aboard SAVA FDA fast track status Micro RNA novel prize cancer destruction RNAZ

When companies split in ways that put them this far above the minimum requirement they usually do so when they expect much more downside and when they want to cater to the low float crowd instead of real investors in the bio space.

Thank you. Someone forwarded this to me, else i wouldnt have anticipated something like that :)
Im not interested in ESPR right now as its really in no mans land. I dont "hold" many bios at all. The market has been brutal past few months. But there are some 70 stocks i monitor daily for action...

$PGHL. Wow! Ran 918% during market hours. AH down 87%.
The opposite of a bear raid.
Prada
9 hours ago

So what happened? I’ll tell you….

Short sellers need only be outside of margin compliance for a fraction of a second for brokers to force automatic buy-ins. Knowing this, offshore scam operators tightly control the float of all these issuers but sometimes leave borrow available to lure in short sellers...

When short sellers bite, the scam operators wash trade a spike in the stock, then keep bid/asks moving during the halt so no unhalt price can be settled upon during regular trading hours. Then, after hours, it unhalts as they rip the price 10x+, causing brokers to force-liquidate accounts that were short. Brokers buy-in to cover the short sales as scam artists sell into the artificially high price.

This can lead to short accounts being wiped out instantly and can even lead to broker losses. The same liquidation scam playbook had been executed previously with other Nasdaq offshore scam tickers such as $ZJYL.

This is terrible

https://finance.yahoo.com/quote/PGHL/

So much for that former insider/fraudster of KBI*O then turned into another turd HYG*N. But altogether, SAVA has been a scam, any public company that works with Maxim is a scam. Period.

Yes indeed!

Exactly.

Nice chatting with you Janice.

Yes, I was surprised to learn kidney beans are somewhat toxic. Toxic enough that you should never cook them in the water you soaked them in. I wouldn't have known were I not an inveterate reader of packaging.

Cassava, from what i have seen, is ingrained into the cultures of Mexican / African / South American diets and they are proud of it.

Their persistence, imo comes from a lack of alternatives and again a culture practice of growing a usable and edible product. Visiting some places in Mexico / Brazil you begin to understand people are just in "survival" mode - use what's available.

The toxicity issue is also common in legume crops such as lima / red kidney beans which are also common in these cultural diets.

And it was first done by pretty primitive people.

Cocoa beans taste pretty crappy before you run them through a 15 step process to get chocolate...Another case of " how did they get from this raw stuff to that?"

Yes, it was an unusual choice of name. Though it's a popular carbohydrate in Central and South America, perhaps the most popular. I've always wondered how many people died before they figured out how to prepare it. And why they were so persistent.

Interesting, just like cassava, which when raw, contains cyanide and is toxic.

https://www.medicalnewstoday.com/articles/323756#is-it-toxic

The name picked by scammers for scammers - how suitable!

Now let's see , where is cassava grown? Mexico / Costa Rica / South America. Insiders probably went straight to the airport after the reverse split, never to be seen again, unless of couse Karma catches up to them, amen.

Appreciate the "scam force" here on Ihub - H Bear too.

Hello again! I found this one remarkable because it was KNOWN that the most important insiders were scammers. And people seem simply to have discounted that, somehow imagining what they produced would be a winner.

Why, hello janice!

Our paths have not crossed for a long time.

Yes, investors still gett'in burnt, will it ever end !? i think not, even i , have had to learn a few lessons from my foolish juvenile days. (lol)

Comprende amigo,

"Its possible for mortals to anticipate a partner in a ph1/ph2 company when their data is about to be due and a BP dropped similar but not equal programs recently"

(cost efficient for a BP to partner up with a smaller biotech demonstrating a superior product in the same category)

The reverse can also be true - eg IMTX, BMY drops out of 1 trial, IMA402 p1/p2 results are poor - same press release in that instance. Was suspicion evident in previous trading - i beleive so, however, hindsight is 20/20

Seriously, did anyone need Shkreli to tell them it was doomed? The follies of management should have been enough.

Congrats on your short here with SAVA.

Your education paid off big time in this instance!

We should probably discuss ESPR further on that board, of course if you are up to that.

Reminds me of of ARGS - that was a stinging lesson for me, ouch...still hurts!

Although i feel bad for investors in SAVA, biotech is high risk and that should be understood by all investors. Lawsuit won't help imo, ... prove wrongdoing against forward looking statements, etc, etc, for 5+ years, imo. - only good for the lawyers, imo.

Ref: Argos Therapeutics

https://x.com/MartinShkreli/status/1859681514415607930

You will all kiss my feet brothers make it all back

Get ready for Fda fast track status for nobel prize micro rna for terminally ill cancer patients

A reverse split is NOT something directors or management wishes to do — we all hope it won’t be needed. But the Nasdaq Hearings Panel that approved the extension to continue our Nasdaq listing did so on the condition that our shareholders authorize a reverse split — should one be necessary. The reverse split will not be necessary if our stock closes at $1.00 per share or more for any ten-day period prior to December 31, 2024.

I have never ever in my life seen a great bio with a chart like this.
SCREAMS promotion campaign - which is something you dont do when you have the next greatest thing in oncology.
Now a 1 for 33 is coming??

"The reverse split will reduce the number of shares of common stock outstanding from 17,265,658 shares to approximately 523,202 shares." per their recent PR. They want to cater to the low float crowd.
A more healthy ratio wouldve done it too...

TransCode Therapeutics Announces Safety Review Committee Approval of Second Cohort Opening in Phase 1 TTX-MC138 Clinical Trial Following Favorable Review of Cohort 1 Safety Data
October 23 2024 - 7:00AM


Share On Facebook

TransCode Therapeutics, Inc. (NASDAQ: RNAZ), the RNA oncology company committed to more effectively treating cancer using RNA therapeutics, today announced that the Safety Review Committee (SRC) monitoring its Phase 1 clinical trial has unanimously approved opening of the second cohort of patients based on its favorable review of Cohort 1 safety data. The therapeutic candidate being evaluated, TTX-MC138, is TransCode’s lead candidate designed to inhibit microRNA-10b, a microRNA critical to the emergence and progression of metastatic cancer. All patients in the first cohort remain on study for continued treatment. No significant safety or dose limiting toxicities have been reported. The dose administered to the second cohort will be approximately double the dose administered to the first cohort.
“An SRC is a group of clinicians and experts that oversee the safety of subjects during the conduct of the trial. The SRC makes decisions on whether and how the study should proceed, including dose escalation and de-escalation decisions per the study design. The recommendations of the SRC are used to decide whether a clinical trial should be continued as designed, changed, or terminated,” commented Sue Duggan, TransCode’s Senior Vice President of Operations. Duggan added, “No dose-limiting toxicities were reported in the first cohort of patients treated with TTX-MC138. Eligible subjects may now be scheduled in Cohort 2 for treatment with the next dose level of TTX-MC138.”

Is FDA And NIH Ascam
TransCode Therapeutics Awarded $2 Million NIH Grant to Support Clinical Evaluation of Lead Candidate
September 05 2024 - 7:00AM


Share On Facebook

TransCode Therapeutics, Inc. (NASDAQ: RNAZ), the RNA oncology company committed to more effectively treating cancer using RNA therapeutics, today announced that it has been awarded a $2 million Direct to Phase II Small Business Innovation Research (SBIR) grant from the National Institutes of Health (NIH) to support clinical evaluation of TTX-MC138, TransCode’s lead therapeutic candidate. TransCode has recently activated three clinical trial sites to conduct a Phase I/II clinical trial of TTX-MC138 for the treatment of advanced solid tumors.


The clinical trial is designed to generate critical data to support evaluation of the safety of TTX-MC138. While efficacy of TTX-MC138 is not an endpoint in this trial, the trial may nevertheless provide early evidence of TTX-MC138 clinical activity in patients with metastatic disease. Funds under the grant are expected to be received over two years.

“We are honored that the NIH recognizes and continues to support our mission to advance therapies against metastatic cancer,” said Zdravka Medarova, Ph.D., Chief Scientific Officer of TransCode. “NIH funding is awarded only after rigorous review. We believe that this award attests to the potential impact, novelty, and robustness of the TTX-MC138 clinical development program.”

TTX-MC138 is a first-in-class therapeutic candidate with novel relevance to metastatic disease. Successful clinical development of TTX-MC138 potentially represents a viable treatment option for many patients with metastatic cancer.

RNAZ FDA Fast track status in progress, they are making everyone panic sell, read between the lines brother, you will kiss my feet and make all your $$ back and more

I was short SAVA.
And believe RNAZ is a scam.

last call for RNAZ cancer cure fda fast track coming about to unleash hell on shorts

Good. But I am glad I sold @ $4.26 yesterday. I am not a member of Congress who gets info. and can inside trade. Ever wonder how a women who's net worth was $319,000 joins Congress and in 4 years her net worth is now $46 Million? They get into Congress and are allowed to inside trade. That's how.

Correct. But there is no one home.

I agree. I was very fortunate to learn from a professional in the bio sector. He taught me that its crucial to understand whats actually being discussed in the share price.
Sometimes, you have very seggsy risk reward ratios......... Where stocks correct upwards.

This is the world we live in when it comes to biotech investing.
Every day is a positive day as long as the company is moving forward and trying to get data that shows promising results. During this long period some stocks go up, some go down but the positivity and promise is there for all investors to hold onto and keep the dream alive.

Then the data comes out and it is not good, or FDA says no.

That is biotech investing - purely speculative with absolutely no control by the management team, other than hurting the stock price during the process with poor deals that are some form of toxic financing.

Biotech investing is not for the faint of heart.

Just in: SRPT to give 850mn upfront in partnership with ARWR...
Another AAV based gene tx seeking RNAI......

I dont know much about Rett but I like their miRARE + aav9 to manage precise mecp2 expression... I like this RNA thermometer/thermostat function. I believe its the way to go.
Whether they will succeed or the stock go up? I dont know.

I agree that there was no problem in the way the Ph3 readout was handled (obviously the content was not positive).

My sense is that SAVA did nothing wrong but there will be class action suits anyway because there always are when a stock drops precipitously.

It is puzzling why the Ph 3 was so blah given the positive results in earlier phases. SAVA lying about earlier results is one possibility, but I think not overly likely. Possibly some selective reporting. Doesn't really matter at this point. These class action lawsuits never proceed to an actual trial where evidence is presented and evaluated. They are always settled out of court with a denial of wrongdoing. If anything SAVA holders will see pennies on the dollar several years from now. Sadly, there will be no full recovery of losses and, apparently, no meds from SAVA for AD patients (even worse).

SAVA Make it all back with RNAZ cancer destruction fast track news for terminally ill cancer patients coming

We do not know enough yet. This ph3 readout wasnt problematic in any way legally speaking.

The question is whether these ph3 results mean they MUST have lied at some point prior. And to what extent.

partnerships and buyouts...
You need very serious edge to play these. Its possible for mortals to anticipate a partner in a ph1/ph2 company when their data is about to be due and a BP dropped similar but not equal programs recently - everything else i would never try to factor in. Leave to the pros.

Of course there will be class action lawsuits against SAVA - that is what class action lawyers do.

Thank you very much for your input.

I like ESPR as well and concur that VRNA is a good comparable.
I think ESPR could move quickly ( 2025) as you mentioned it is a BIG space.

https://www.esperion.com/news-releases/news-release-details/us-fda-approves-broad-new-labels-nexletolr-and-nexlizetr-prevent

The next sign most shareholders are looking for is a U.S. partnership / Canada - Australia filing / and of course the ultimate - a buyout.

2024 imo, has been a milestone year for ESPR, however the market appears skeptical. Hopefully script growth continues / revenue continues to grow, just not sure if mgmt. can execute as it should.

( I came across ESPR as i was reviewing a litigation case Esperion vs. Daiichi Sankyo Europe about 1 year ago. That case settled in January/24 - i viewed that as a pivotal positive and credit to ESPR mgmt. )

Charity starts from home.

From Adam F.

Cassava Sciences and its Alzheimer’s drug are done. The damage lingers
While many investors lost money, the bigger tragedy involves patients

Four years on, the Cassava Sciences story ended Monday exactly as many knew it would — with the company’s experimental drug for Alzheimer’s disease, simufilam, proving to be nothing more than a placebo in a large clinical trial.

The negative outcome is devastating for the nearly 2,000 participants in this study and a second study also shut down Monday. Clinical trials in Alzheimer’s fail all too frequently, but simufilam was built on falsified research and misleading efficacy claims. The drug should never have advanced this far.

https://www.statnews.com/2024/11/25/cassava-sciences-simufilam-trial-failure/

GOD bless,