FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

THOMAS H. LEE ADVISORS, LLC
2. Issuer Name and Ticker or Trading Symbol

Syneos Health, Inc. [ SYNH ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    __X__ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)

C/O THOMAS H. LEE PARTNERS, L.P., 100 FEDERAL STREET, 35TH FLOOR
3. Date of Earliest Transaction (MM/DD/YYYY)

3/3/2021
(Street)

BOSTON, MA 02110
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Class A Common Stock 3/3/2021  S  3717905 (4)D$74.175 9517640 (5)I See footnote (1)(2)(3)
Class A Common Stock 3/3/2021  S  277114 (6)D$74.175 9106651 (7)I See footnote (1)(2)(3)
Class A Common Stock 3/3/2021  S  631 (8)D$74.175 1535 (10)D  
Class A Common Stock 3/3/2021  S  242 (9)D$74.175 589 (11)D  
Class A Common Stock 3/3/2021  S  45 (12)D$74.175 1490 (14)D  
Class A Common Stock 3/3/2021  S  17 (13)D$74.175 572 (15)D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares

Explanation of Responses:
(1) See Exhibit 99.1 for text of footnote (1).
(2) See Exhibit 99.1 for text of footnote (2).
(3) See Exhibit 99.1 for text of footnote (3).
(4) See Exhibit 99.1 for text of footnote (4).
(5) See Exhibit 99.1 for text of footnote (5).
(6) See Exhibit 99.1 for text of footnote (6).
(7) See Exhibit 99.1 for text of footnote (7).
(8) See Exhibit 99.1 for text of footnote (8).
(9) See Exhibit 99.1 for text of footnote (9).
(10) See Exhibit 99.1 for text of footnote (10).
(11) See Exhibit 99.1 for text of footnote (11).
(12) See Exhibit 99.1 for text of footnote (12).
(13) See Exhibit 99.1 for text of footnote (13).
(14) See Exhibit 99.1 for text of footnote (14).
(15) See Exhibit 99.1 for text of footnote (15).

Remarks:
Exhibit 99.1 (Form 4 Footnotes) and Exhibit 99.2 (Joint Filer Information) are incorporated herein by reference. This Form 4 is the first of two Forms 4 being filed relating to the same event. The Form 4 has been split into two filings because there are more than 10 Reporting Persons in total, and the SEC's EDGAR filing system limits a single Form 4 to a maximum of 10 Reporting Persons. Each Form 4 will be filed by Designated Filer Thomas H. Lee Advisors, LLC.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
THOMAS H. LEE ADVISORS, LLC
C/O THOMAS H. LEE PARTNERS, L.P.
100 FEDERAL STREET, 35TH FLOOR
BOSTON, MA 02110
XX

THL Fund VII Coinvestment Partners, L.P.
C/O THOMAS H. LEE PARTNERS, L.P.
100 FEDERAL STREET, 35TH FLOOR
BOSTON, MA 02110
XX

THL Executive Fund VII, L.P.
C/O THOMAS H. LEE PARTNERS, L.P.
100 FEDERAL STREET, 35TH FLOOR
BOSTON, MA 02110
XX

THL Equity Fund VII Investors (inVentiv), L.P.
C/O THOMAS H. LEE PARTNERS, L.P.
100 FEDERAL STREET, 35TH FLOOR
BOSTON, MA 02110
XX


Signatures
** See Exhibit 99.2 for Signatures3/5/2021
**Signature of Reporting PersonDate

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