We are offering 4,148 shares of our Series
1 convertible non-voting preferred stock, or the Series 1 preferred stock, which is convertible into our common stock from time
to time upon conversion of our Series 1 preferred stock. Our common stock is listed on The Nasdaq Capital Market under the symbol
“TARA.” On September 21, 2020, the last reported sale price of our common stock was $16.87 per share. There is no established
trading market for the Series 1 preferred stock and we do not expect a market to develop. In addition, we do not intend to list
the Series 1 preferred stock on The Nasdaq Capital Market, any other national securities exchange or any other nationally recognized
trading system.
Concurrently with this offering of Series
1 preferred stock, and pursuant to a separate prospectus supplement, we are offering 4,600,000 shares of our common stock, which
we refer to herein as the Concurrent Offering.
Delivery of the shares of Series 1 preferred
stock in this offering is expected to be made on or about September 24, 2020.
ABOUT
THIS PROSPECTUS SUPPLEMENT
This
document is part of a “shelf” registration statement on Form S-3 (file no. 333-238273) that we filed with the Securities
and Exchange Commission, or the SEC, and is in two parts. The first part is this prospectus supplement, which describes the specific
terms of this offering and also adds to and updates information contained in the accompanying prospectus and the documents incorporated
by reference herein. The second part, the accompanying prospectus, provides more general information. Generally, when we refer
to this prospectus, we are referring to both parts of this document combined. To the extent there is a conflict between the information
contained in this prospectus supplement and the information contained in the accompanying prospectus or any document incorporated
by reference therein filed prior to the date of this prospectus supplement, you should rely on the information in this prospectus
supplement; provided that if any statement in one of these documents is inconsistent with a statement in another document having
a later date—for example, a document incorporated by reference in the accompanying prospectus—the statement in the
document having the later date modifies or supersedes the earlier statement.
We
further note that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any
document that is incorporated by reference herein were made solely for the benefit of the parties to such agreement, including,
in some cases, for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation,
warranty or covenant to you. Moreover, such representations, warranties or covenants were accurate only as of the date when made.
Accordingly, such representations, warranties and covenants should not be relied on as accurately representing the current state
of our affairs.
Neither
we nor the underwriters have authorized anyone to provide any information other than that contained or incorporated by reference
in this prospectus supplement or in the accompanying prospectus. We take no responsibility for, and can provide no assurance as
to the reliability of, any other information that others may give you. This prospectus supplement and the accompanying prospectus
do not constitute an offer to sell, or a solicitation of an offer to purchase, the securities offered by this prospectus supplement
and the accompanying prospectus in any jurisdiction to or from any person to whom or from whom it is unlawful to make such offer
or solicitation of an offer in such jurisdiction. The information contained in this prospectus supplement or the accompanying
prospectus, or incorporated by reference herein or therein, is accurate only as of the respective dates hereof or thereof, as
the case may be, regardless of the time of delivery of this prospectus supplement and the accompanying prospectus or of any sale
of our securities. It is important for you to read and consider all information contained in this prospectus supplement and the
accompanying prospectus, including the documents incorporated by reference herein and therein, in making your investment decision.
You should also read and consider the information in the documents to which we have referred you in the sections entitled “Where
You Can Find More Information” and “Incorporation of Certain Information by Reference” in this prospectus supplement
and in the accompanying prospectus.
We
are offering to sell, and seeking offers to buy, shares of our Series 1 preferred stock (and the underlying shares of common stock)
only in jurisdictions where offers and sales are permitted. The distribution of this prospectus supplement and the accompanying
prospectus and the offering in certain jurisdictions may be restricted by law. Persons outside the United States who come into
possession of this prospectus supplement and the accompanying prospectus must inform themselves about, and observe any restrictions
relating to, the offering and the distribution of this prospectus supplement and the accompanying prospectus outside the United
States. This prospectus supplement and the accompanying prospectus do not constitute, and may not be used in connection with,
an offer to sell, or a solicitation of an offer to buy, any securities offered by this prospectus supplement and the accompanying
prospectus by any person in any jurisdiction in which it is unlawful for such person to make such an offer or solicitation.
Unless
otherwise stated, all references in this prospectus supplement to “we,” “us,” “our,” “Protara,”
the “Company” and similar designations refer to Protara Therapeutics, Inc. This prospectus supplement and the accompanying
prospectus contain references to trademarks belonging to other entities. Solely for convenience, trademarks and trade names referred
to in this prospectus supplement, including logos, artwork and other visual displays, may appear without the ® or ™
symbols, but such references are not intended to indicate, in any way, that the applicable licensor will not assert, to the fullest
extent under applicable law, its rights to these trademarks and trade names. We do not intend our use or display of other companies’
trade names or trademarks to imply a relationship with, or endorsement or sponsorship of us by, any other companies.
PROSPECTUS
SUPPLEMENT SUMMARY
This
summary highlights selected information contained elsewhere in this prospectus supplement and the accompanying prospectus and
in the documents we incorporate by reference. This summary does not contain all of the information you should consider before
investing in our securities. You should read this entire prospectus supplement and the accompanying prospectus carefully, especially
the risks of investing in our securities discussed under the section titled “Risk Factors” in this prospectus supplement
and under similar headings our Annual Report on Form 10-K for the year ended December 31, 2019 and in our Quarterly Report on
Form 10-Q for the quarter ended June 30, 2020, which are incorporated by reference into this prospectus supplement, along with
our consolidated financial statements and notes to those consolidated financial statements and the other information incorporated
by reference in this prospectus supplement and the accompanying prospectus, before making an investment decision.
Company
Overview
We
are a New York City based clinical-stage biopharmaceutical company focused on identifying and advancing transformative therapies
for the treatment of cancer and rare diseases with significant unmet needs. We prioritize creativity, diverse perspectives, integrity
and tenacity to expedite our goal of bringing life-changing therapies to people with limited treatment options.
Our
lead program, TARA-002, is an investigational cell therapy based on the broad immunopotentiator, OK-432, which is approved in
Japan and Taiwan for the treatment of lymphatic malformations (LMs) and multiple oncologic indications. We are initially developing
TARA-002 in the U.S. for the treatment of LMs. In addition, we are developing TARA-002 in the U.S. for the treatment of non-muscle
invasive bladder cancer (NMIBC). In July 2020, the U.S. Food and Drug Administration, or FDA, granted Rare Pediatric Disease designation
for TARA-002 for the treatment of LMs.
Bladder
cancer is the sixth most common cancer in the United States, with NMIBC representing approximately 80% of bladder cancer diagnoses.
Approximately 65,000 patients are diagnosed with NMIBC in the United States each year. NMIBC is cancer found in the tissue that
lines the inner surface of the bladder that has not spread into the bladder muscle. The current standard of care for NMIBC includes
intravesical Bacillus Calmette-Guerin (BCG), which has been the subject of multiple global supply shortages in the past decade
due to the inability to meet demand to treat the large worldwide population of patients with NMIBC.
Building
on existing safety and efficacy data from OK-432, and subject to the completion of non-clinical studies as well as acceptance
of an Investigational New Drug (IND) application, we plan to commence a Phase 1 clinical trial in 2021 to assess the safety and
tolerability of TARA-002 in patients with High Grade NMIBC, potentially including patients with carcinoma in situ (CIS), with
results expected in 2022. We are currently in the planning stages for the Phase 2 clinical development program, which if the Phase
1 trial is successful, we will plan to commence with our first Phase 2 clinical trial in this indication in 2022. The Phase 2
trials are expected to include High Grade NMIBC patients with CIS +/- Ta and/or T1 papillary tumors and high grade Ta and/or T1
papillary tumors without CIS.
We
plan to file an updated IND and to engage the FDA by the end of 2020 to discuss the regulatory approval path for TARA-002 in LMs,
including the requirements for a biologics license application, or BLA. Specifically, we plan to discuss with the FDA whether
OK-432’s more than 25-year safety database in LMs outside the U.S., as well as the significant treatment effect and safety
database from the clinical trials conducted in the US and led by the University of Iowa, are sufficient for a BLA submission for
TARA-002. Based on our interaction with the FDA, we may need to conduct additional clinical trials.
TARA-002
was developed from the same master cell bank of genetically distinct group A Streptococcus pyogenes as OK-432 (marketed as Picibanil®
in Japan and Taiwan by Chugai Pharmaceutical Co., Ltd., or Chugai Pharmaceutical). Following a recent pre-IND interaction
with the Office of Tissues and Advanced Therapies division of the Center for Biologics Evaluation and Research (CBER), the FDA
agreed that we have successfully demonstrated initial manufacturing comparability between TARA-002 and OK-432 and that we were
on track with our plans to conduct testing on three large-scale batch runs required to confirm comparability. Good Manufacturing
Practice (GMP) scale up is currently in process and we plan to initiate GMP comparability runs with an expected completion date
in mid-2021.
The
second development program in our portfolio is intravenous (IV) Choline Chloride, an investigational phospholipid substrate replacement
therapy initially in development for patients receiving parenteral nutrition (PN) who have intestinal failure associated liver
disease (IFALD). IV Choline Chloride has been granted Orphan Drug Designation by the FDA for this indication and has also been
granted Fast Track Designation for the treatment of IFALD.
Our
third program, vonapanitase, is a recombinant human elastase. We are reviewing the research and preclinical and clinical data
of vonapanitase and have not yet determined whether to pursue further development of this product candidate in the future.
We
have devoted substantial efforts to the development of these programs. We do not have any approved products and have not generated
any revenue from product sales. The lead program, TARA-002, is in later stage development and has not yet been approved for use
for treatment of LMs, NMIBC or any other indications. The Company does not expect to generate any significant revenues prior to
2022, if ever. To finance the Company’s current strategic plans, including the conduct of ongoing and future clinical trials
and further research and development costs, the Company will need to raise additional capital.
Corporate
Information
We
were originally incorporated in March 2006 in the State of Delaware under the name Proteon Therapeutics, Inc., and at that time,
acquired Proteon Therapeutics, LLC, our predecessor, which was formed in June 2001. In January 2020, we effected a reverse merger,
pursuant to which a wholly owned subsidiary of ours merged with and into ArTara Subsidiary, Inc. (f/k/a ArTara Therapeutics,Inc.,
“Private ArTara”), with Private ArTara surviving as a wholly owned subsidiary of ours. In January 2020, we changed
our name from Proteon Therapeutics, Inc. to ArTara Therapeutics, Inc., and in May 2020, we changed our name from ArTara Therapeutics,
Inc. to Protara Therapeutics, Inc. Our principal executive offices are located at 1 Little West 12th Street, New York, New York
10014, our telephone number is (646) 844-0337 and our website address is www.protaratx.com. The information contained in or accessible
through our website does not constitute part of this prospectus.
Concurrent
Offering of Common Stock
Concurrently with this offering of Series
1 preferred stock, we are offering 4,600,000 shares of our common stock, which we refer to as the Concurrent Offering. The Concurrent
Offering is being conducted as a separate public offering by means of a separate prospectus supplement. We cannot assure you that
either or both of the offerings will be completed.
THE
OFFERING
Series 1 preferred stock to be offered by us
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4,148 shares. This prospectus supplement also relates to the offering of 4,148,869 shares of common stock issuable upon conversion of the Series 1 preferred stock.
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Series 1 preferred stock to be outstanding immediately following this offering
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8,027.356 shares
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Conversion
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Each
share of Series 1 preferred stock is convertible into shares of common stock as set forth in the certificate of designation
for the Series 1 preferred stock, at a conversion rate equal to the stated value of $7,011.47 per share divided by an initial
conversion price of $7.01 per share, subject to adjustment for any stock splits, stock dividends and similar events, at any
time at the option of the holder, provided that any conversion of Series 1 preferred stock by a holder into shares of common
stock would be prohibited if, as a result of such conversion, the holder, together with its affiliates and any other person
or entity whose beneficial ownership of the common stock would be aggregated with such holder’s for purposes of Section
13(d) of the Securities Exchange Act of 1934, as amended, would beneficially own more than 9.99% of the total number of shares
common stock issued and outstanding after giving effect to such conversion. Upon 61 days’ written notice to us, the
holder may from time to time increase or decrease such limitation to any other percentage not in excess of 19.99% specified
in such notice.
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Liquidation
preference
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In
the event of our liquidation, each share of Series 1 preferred stock is entitled to a preference of $10.00 per share and thereafter
will share ratably in any distributions or payments on an as-converted basis with the holders of our common stock.
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Voting
rights
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Shares
of Series 1 preferred stock will generally have no voting rights, except as required by law. The consent of 66.6% of the then-outstanding
shares of Series 1 preferred stock is required for us to effect any amendment to the certificate of designation for the Series
1 preferred stock that alters or changes the powers, preferences, rights or other terms of the Series 1 Preferred Stock, or
to directly or indirectly (whether by amendment, corporate action, by contract, by merger or otherwise), increase the number
of authorized shares of Series 1 preferred stock, consummate or consent to certain transactions, or enter into any agreement
with respect to any of the foregoing.
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Dividends
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Shares
of Series 1 preferred stock will be entitled to receive dividends at a rate equal to (on an as-if-converted-to-common stock
basis), and in the same form and manner as, dividends actually paid on shares of our common stock.
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Use
of proceeds
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We
currently intend to use the net proceeds from this offering and the Concurrent Offering, together with other available funds,
primarily for development activities associated with TARA-002 in NMIBC, LMs and potential exploration of additional
indications. We intend to use the remainder of the net proceeds for general corporate purposes and working capital. See
“Use of Proceeds.”
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Risk
factors
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An
investment in our securities involves a high degree of risk. See the section titled “Risk Factors” in this prospectus
supplement and under similar headings in the other documents that are incorporated by reference herein and therein.
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Concurrent Offering
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Concurrently with this offering, we are conducting the Concurrent Offering, pursuant to which we are offering 4,600,000 shares of our common stock. The Concurrent Offering is being conducted as a separate public offering by means of a separate prospectus supplement.
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Listing
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There
is no established public trading market for the Series 1 preferred stock, and we do not expect a market to develop. In addition,
we do not intend to apply for listing of the Series 1 preferred stock on The Nasdaq Capital Market or on any national securities
or other nationally recognized trading system. Our common stock is listed on The Nasdaq Capital Market under the symbol “TARA.”
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The
number of shares of Series 1 preferred stock outstanding as of June 30, 2020 was 3,879.356.
The
number of shares of our common stock outstanding as of June 30, 2020 was 5,843,203 shares, which excludes as of June 30, 2020:
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518,292
shares of our common stock issuable upon the exercise of stock options outstanding under
our 2014 Stock Plan, as amended, or 2014 Plan, our 2017 Equity Incentive Plan, or 2017
Plan, and our 2020 Inducement Plan, or Inducement Plan, at a weighted average exercise
price of $22.78 per share;
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317,114
shares of common stock reserved for future issuance under our 2014 Plan, plus any additional shares of our common stock that
may become available under our 2014 Plan;
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560,550
shares of our common stock reserved for issuance under our Inducement Plan, plus any additional shares of our common stock
that may become available under our Inducement Plan;
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13,340
shares of our common stock reserved for issuance under our 2014 Employee Stock Purchase Plan, or ESPP, as well as any future
increases in the number of shares of our common stock reserved for issuance under the ESPP;
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387,157
shares of common stock issuable upon the vesting of outstanding restricted stock units;
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89,913
shares of common stock issuable upon the settlement of vested restricted stock units;
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3,880,170 shares of our common stock issuable upon the conversion of 3,879.356 shares of our Series 1 preferred stock outstanding;
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4,600,000 shares of our common stock being offered by us in the Concurrent Offering; and
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4,148,869 shares of our common stock issuable upon the conversion of shares of Series 1 preferred stock being offered by us in connection with this offering.
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Except
as otherwise indicated, the information in this prospectus supplement assumes no exercise of the outstanding stock options, no
conversion of the outstanding Series 1 preferred stock and no exercise by the underwriters of their option to purchase additional
shares in the Concurrent Offering.
RISK
FACTORS
An
investment in our securities involves a high degree of risk. Before deciding whether to invest in our securities, you should carefully
consider the risks described below and those discussed under the section titled “Risk Factors” contained in our Annual
Report on Form 10-K for the year ended December 31, 2019 and in our Quarterly Report on Form 10-Q for the quarter ended June 30,
2020, each as updated by our annual, quarterly and other reports and documents that are incorporated by reference in this prospectus
supplement and the accompanying prospectus, together with other information in this prospectus supplement, the accompanying prospectus,
the information and documents incorporated by reference herein and therein, and in any free writing prospectus that we have authorized
for use in connection with this offering. Such risks may be amplified by the COVID-19 pandemic and its potential impact on our
business and the global economy. If any of these risks actually occurs, our business, financial condition, results of operations
or cash flow could be seriously harmed. This could cause the trading price of our common stock (including the common stock issuable
upon conversion of the Series 1 preferred stock issued in this offering) to decline, resulting in a loss of all or part of your
investment.
Risks
Related to this Offering
If
you purchase our Series 1 preferred stock in this offering, assuming it is converted into shares of our common stock, you will
experience immediate and substantial dilution in investment. You will experience further dilution if we issue additional equity
securities in future financing transactions.
Since the public offering price per share
attributable to each share of common stock issuable upon conversion of Series 1 preferred stock being offered is higher than the
net tangible book value per share of our common stock, you will suffer immediate and substantial dilution in the net tangible book
value of the common stock issuable upon the conversion of Series 1 preferred stock you purchase in this offering. As a result,
investors in this offering will incur immediate dilution of approximately $7.25 per share, representing the difference between
the public offering price of $16.87 per share of common stock into which the shares of Series 1 preferred stock being offered in
this offering are convertible and our net tangible book value as of June 30, 2020, assuming the conversion of our shares of Series
1 preferred stock to be issued in this offering into shares of common stock, but excluding the effect of the conversion of the
outstanding shares of Series 1 preferred stock and the shares of common stock to be issued in the Concurrent Offering. In addition,
we have a significant number of stock options outstanding. To the extent that outstanding stock options have been or may be exercised,
or shares of our common stock are issued in the Concurrent Offering, investors in this offering may experience further dilution.
We
will require more capital to conduct the costly and time-consuming clinical trials necessary to pursue regulatory approval of
each of our potential product candidates and to continue the development of TARA-002 and IV Choline Chloride in new indications
or uses. In addition, we may choose to raise additional capital due to market conditions or strategic considerations even if we
believe we have sufficient funds for our current or future operating plans. To the extent that additional capital is raised through
the sale of equity or convertible debt securities, the issuance of these securities could result in further dilution to our stockholders
or result in downward pressure on the price of our common stock. See the section titled “Dilution” for a more detailed
discussion of the dilution you will incur if you purchase Series 1 preferred stock in this offering.
There
is no public market for our Series 1 preferred stock.
There
is no established public trading market for our Series 1 preferred stock, and we do not expect a market to develop. In addition,
we do not intend to apply for listing of the Series 1 preferred stock on any national securities exchange or other nationally
recognized trading system. Without an active market, the liquidity of the Series 1 preferred stock will be limited.
Our
management might apply the net proceeds from this offering and the Concurrent Offering in ways with which you do not agree and
in ways that may impair the value of your investment.
We
currently intend to use the net proceeds from this offering and the Concurrent Offering primarily to fund the development of our
product candidates and for working capital and general corporate purposes. We may also use the net proceeds from this offering
and the Concurrent Offering for certain pre-commercialization activities and to acquire or invest in businesses, products or technologies
that are complementary to our own, although we have no current plans, commitments or agreements with respect to any acquisitions
as of the date of this prospectus supplement. Pending the use of net proceeds from this offering and the Concurrent Offering as
further described in the section titled “Use of Proceeds,” we intend to invest the net proceeds in short-term, investment-grade,
interest bearing obligations, certificates of deposit or direct or guaranteed obligations of the United States. Our management
has broad discretion as to the use of these proceeds and you will be relying on the judgment of our management regarding the application
of these proceeds. We might apply these proceeds in ways with which you do not agree, or in ways that do not yield a favorable
return. If our management applies these proceeds in a manner that does not yield a significant return, if any, on our investment
of these net proceeds, it could compromise our ability to pursue our growth strategy and adversely affect the market price of
our common stock.
Concentration
of ownership of our common stock among our existing executive officers, directors and principal stockholders may prevent new investors
from influencing significant corporate decisions.
Based
upon our shares of our common stock outstanding as of September 18, 2020, our executive officers, directors and stockholders
who own more than 5% of our outstanding common stock before this offering, in the aggregate, beneficially own shares representing
approximately 85% of our outstanding common stock (excluding the effect of the conversion of the shares of Series 1 preferred
stock to be issued in this offering into shares of common stock). These stockholders, acting together, will be able to significantly
influence all matters requiring stockholder approval, including the election and removal of directors and any merger or other
significant corporate transactions. The interests of this group of stockholders may not coincide with the interests of other stockholders.
SPECIAL
NOTE REGARDING FORWARD-LOOKING STATEMENTS
This
prospectus supplement, the accompanying prospectus, the documents incorporated by reference and any free writing prospectus that
we have authorized for use in connection with this offering contain “forward-looking statements” within the meaning
of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act
of 1934, as amended, or the Exchange Act, which are subject to the “safe harbor” created by those sections. We may,
in some cases, use words such as “anticipate,” “believe,” “could,” “estimate,”
“expect,” “intend,” “may,” “plan,” “potential,” “predict,”
“project,” “should,” “will,” “would” or the negative of those terms, and similar
expressions that convey uncertainty of future events or outcomes to identify these forward-looking statements. Any statements
contained herein that are not statements of historical facts may be deemed to be forward-looking statements. Forward-looking statements
may include, but are not limited to, statements about:
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the
impact of the COVID-19 pandemic on our business and operations as well as the business or operations of our manufacturers,
research partners, research sites, and other third parties with whom we conduct business or regulatory agencies;
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estimates
regarding our financial performance, including future revenue, expenses and capital requirements
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our
expected cash position and ability to obtain financing in the future on satisfactory terms or at all;
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expectations
regarding our plans to research, develop and commercialize our current and future product candidates, including TARA-002,
and Intravenous (IV) Choline Chloride;
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expectations
regarding the safety and efficacy of our product candidates;
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expectations
regarding the timing, costs and outcomes of our planned non-clinical studies and clinical trials;
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expectations
regarding potential market size;
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expectations
regarding enrollment and the timing of the availability of data from our non-clinical studies and clinical trials;
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expectations
regarding the clinical utility, potential benefits and market acceptance of our product candidates;
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expectations
regarding our commercialization, marketing and manufacturing capabilities and strategy;
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the
implementation of our business model, strategic plans for our business, product candidates and technology;
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expectations
regarding our ability to identify additional products or product candidates with significant commercial potential;
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developments
and projections relating to the combined our competitors and industry;
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our
ability to remain listed on the Nasdaq Capital Market;
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the
impact of government laws and regulations;
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the
timing or likelihood of regulatory filings and approvals;
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our
ability to protect our intellectual property position;
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the
successful completion of this offering and the Concurrent Offering; and
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our
expected use of proceeds from this offering.
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These
forward-looking statements reflect our management’s beliefs and views with respect to future events and are based on estimates
and assumptions as of the date of this prospectus supplement and are subject to risks and uncertainties. We discuss many of these
risks in greater detail under the section titled “Risk Factors” in this prospectus supplement and under similar headings
in the other documents that are incorporated by reference herein and therein. Moreover, we operate in a very competitive and rapidly
changing environment. New risks emerge from time to time. It is not possible for our management to predict all risks, nor can
we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual
results to differ materially from those contained in any forward-looking statements we may make. Given these uncertainties, you
should not place undue reliance on these forward-looking statements.
You
should read this prospectus supplement and the accompanying prospectus together with the documents that we have filed with the
SEC that are incorporated by reference and any free writing prospectus we have authorized for use in connection with a specific
offering completely and with the understanding that our actual future results may be materially different from what we expect.
We qualify all of the forward-looking statements in this prospectus supplement and the accompanying prospectus, and the documents
incorporated herein and therein, by these cautionary statements. Except as required by law, we undertake no obligation to update
any forward-looking statements, whether as a result of new information, future events or otherwise.
USE
OF PROCEEDS
We expect to receive approximately $66.4
million in net proceeds from the sale of 4,148 shares of Series 1 preferred stock offered by us in this offering, after deducting
underwriting discounts and commissions and estimated offering expenses payable by us. In addition, we estimate that the net proceeds
we will receive from the Concurrent Offering will be approximately $73.7 million (or approximately $84.8 million if the underwriters
exercise their option to purchase additional shares of common stock in full), after deducting underwriting discounts and commissions
and estimated offering expenses payable by us.
We
expect to use the net proceeds from this offering and the Concurrent Offering, together with other available funds, for the
development activities associated with TARA-002 in NMIBC, LMs and potential exploration of additional indications. We
intend to use the remainder of the net proceeds from this offering and the Concurrent Offering for general corporate purposes
and working capital.
The
expected use of the net proceeds from this offering and the Concurrent Offering represents our intentions based upon our current
plans and business conditions, which could change in the future as our plans and business conditions evolve. The amounts and timing
of our actual expenditures depend on numerous factors, including the progress of our preclinical development efforts, the ongoing
status of and results from our clinical trials and other studies and any unforeseen cash needs. As a result, our management will
have broad discretion in applying the net proceeds from this offering and the Concurrent Offering. Pending the use of net proceeds,
we plan to invest the net proceeds in short- and intermediate-term interest-bearing obligations,
investment-grade securities, certificates of deposit or government securities.
DILUTION
Our
net tangible book value as of June 30, 2020 was $29.7 million, or $5.08 per share. Net tangible book value per share is determined
by dividing our total tangible assets, less total liabilities, by the number of shares of our common stock outstanding as of June
30, 2020. Dilution with respect to net tangible book value per share of common stock represents the difference between the amount
per share of common stock attributable to investors purchasing shares of Series 1 preferred stock in this offering and the net
tangible book value per share of our common stock immediately after this offering (excluding the effect of the conversion of the
outstanding shares of Series 1 preferred stock and the shares of common stock to be issued in the Concurrent Offering).
After giving effect to the sale of 4,148
shares of our Series 1 preferred stock in this offering at a public offering price of $16,873.54 per share, assuming the conversion
of all shares of our Series 1 preferred stock sold in this offering into 4,148,869 shares of our common stock, and after deducting
underwriting discounts and commissions and estimated offering expenses payable by us, our as adjusted net tangible book value as
of June 30, 2020 would have been approximately $96.1 million, or $9.62 per share. This represents an immediate increase in
net tangible book value of $4.54 per share to existing stockholders and immediate dilution of $7.25 per share of common stock into
which the shares of Series 1 preferred stock are convertible to investors in this offering. The following table illustrates this
dilution on a per share of common stock basis (assuming the conversion of all shares of Series 1 preferred stock being offered
in this offering):
Public
offering price per share of common stock into which the shares of Series 1 preferred stock being offered in this offering
are convertible
|
|
|
|
|
|
$
|
16.87
|
|
Net
tangible book value per share of common stock as of June 30, 2020
|
|
$
|
5.08
|
|
|
|
|
|
Increase
in net tangible book value per share of common stock attributable to investors purchasing Series 1 preferred stock in this
offering
|
|
$
|
4.54
|
|
|
|
|
|
As
adjusted net tangible book value per share of common stock as of June 30, 2020, after giving effect to this offering
|
|
|
|
|
|
$
|
9.62
|
|
Dilution
per share of common stock to investors purchasing Series 1 preferred stock in this offering
|
|
|
|
|
|
$
|
7.25
|
|
The
above discussion and table are based on 5,843,203 shares of our common stock outstanding as of June 30, 2020, which excludes as
of June 30, 2020:
|
●
|
518,292
shares of our common stock issuable upon the exercise of stock options outstanding under our 2014 Stock Plan, as amended,
or 2014 Plan, our 2017 Equity Incentive Plan, or 2017 Plan, and our 2020 Inducement Plan, or Inducement Plan, at a weighted
average exercise price of $22.78 per share;
|
|
|
|
|
●
|
317,114
shares of common stock reserved for future issuance under our 2014 Plan, plus any additional shares of our common stock that
may become available under our 2014 Plan;
|
|
|
|
|
●
|
560,550
shares of our common stock reserved for issuance under our Inducement Plan, plus any additional shares of our common stock
that may become available under our Inducement Plan;
|
|
|
|
|
●
|
13,340
shares of our common stock reserved for issuance under our 2014 Employee Stock Purchase Plan, or ESPP, as well as any future
increases in the number of shares of our common stock reserved for issuance under the ESPP;
|
|
|
|
|
●
|
387,157
shares of common stock issuable upon the vesting of outstanding restricted stock units;
|
|
|
|
|
●
|
89,913
shares of common stock issuable upon the settlement of vested restricted stock units;
|
|
|
|
|
●
|
3,880,170
shares of our common stock issuable upon the conversion of 3,879.356 shares of our Series 1 preferred stock outstanding;
|
|
|
|
|
●
|
4,600,000 shares of our common stock being offered by us in the Concurrent Offering; and
|
|
|
|
|
●
|
4,148,869 shares of our common stock issuable upon the conversion of shares of Series 1 preferred stock being offered by us in connection with this offering.
|
The above discussion and table do not take
into account giving effect to the 4,600,000 shares of common stock offered by us in the Concurrent Offering at the public offering
price of $16.87 per share. Giving effect to both this offering and the Concurrent Offering (assuming no exercise of the underwriters’
option to purchase additional shares in the Concurrent Offering), our as adjusted net tangible book value as of June 30, 2020,
would have been approximately $169.8 million, or $11.63 per share of common stock (assuming conversion of all shares of Series
1 preferred stock offered in this offering), which represents an immediate increase in net tangible book value of $6.55 per share
of common stock to existing stockholders and immediate dilution in net tangible book value of $5.24 per share of common stock into
which the shares of Series 1 preferred stock are convertible to investors participating in this offering.
To
the extent that outstanding options outstanding as of June 30, 2020 have been or may be exercised or other shares are issued,
or other shares of common stock are issued, including shares of our common stock issuable upon conversion of our outstanding Series
1 preferred stock or Series 1 preferred stock being offered in the Concurrent Offering, investors in this offering may experience
further dilution. We will require more capital to pursue our preclinical and clinical activities, regulatory approval and the
commercialization of our current or future drug candidates. In addition, we may also choose to raise additional capital due to
market conditions or strategic considerations even if we believe we have sufficient funds for our current or future operating
plans. To the extent that additional capital is raised through the sale of equity or convertible debt securities, the issuance
of these securities could result in further dilution to our stockholders.
CONCURRENT
OFFERING OF COMMON STOCK
Concurrently with
this offering of Series 1 Preferred Stock and pursuant to a separate prospectus supplement, we are offering 4,600,000 shares of
our common stock. Through this offering and the Concurrent Offering we intend to raise gross proceeds of approximately $147.6 million,
based on the public offering price of $16,873.54 per share of Series 1 Preferred Stock and the public offering price of $16.87
per share of common stock.
UNDERWRITING
We
and the underwriters for the offering named below have entered into an underwriting agreement with respect to the Series 1 preferred
stock being offered. Subject to the terms and conditions of the underwriting agreement, each underwriter has severally agreed
to purchase from us the number of shares of our Series 1 preferred stock set forth opposite its name below. Cowen and Company,
LLC, or Cowen, and Guggenheim Securities, LLC are the representatives of the underwriters, or the Representatives.
Underwriters
|
|
Number of
Shares
|
|
Cowen and Company, LLC
|
|
|
2,489
|
|
Guggenheim Securities, LLC
|
|
|
1,037
|
|
Oppenheimer & Co. Inc.
|
|
|
415
|
|
H.C. Wainwright & Co., LLC
|
|
|
207
|
|
Total
|
|
|
4,148
|
|
The
underwriting agreement provides that the obligations of the underwriters are subject to certain conditions precedent and that
the underwriters have agreed, severally and not jointly, to purchase all of the shares sold under the underwriting agreement if
any of these shares are purchased. If an underwriter defaults, the underwriting agreement provides that the purchase commitments
of the non- defaulting underwriters may be increased or the underwriting agreement may be terminated.
We
have agreed to indemnify the underwriters against specified liabilities, including liabilities under the Securities Act and to
contribute to payments the underwriters may be required to make in respect thereof.
The
underwriters are offering the shares, subject to prior sale, when, as and if issued to and accepted by them, subject to approval
of legal matters by their counsel and other conditions specified in the underwriting agreement. The underwriters reserve the right
to withdraw, cancel or modify offers to the public and to reject orders in whole or in part.
Discounts
and Commissions. The following table shows the public offering price, underwriting discount and proceeds,
before expenses to us.
|
|
Per Share
|
|
|
Total
|
|
Public offering price
|
|
$
|
16,873.54
|
|
|
$
|
69,991,444
|
|
Underwriting discount
|
|
$
|
717.12545
|
|
|
$
|
2,974,636
|
|
Proceeds, before expenses, to us
|
|
$
|
16,156.41455
|
|
|
$
|
67,016,808
|
|
The
underwriters propose to offer the shares of Series 1 preferred stock to the public at the public offering price set forth on the
cover page of this prospectus. If all of the shares are not sold at the public offering price, the underwriters may change the
offering price and other selling terms.
We have engaged
Ladenburg Thalmann & Co. Inc., or Ladenburg, as our financial advisor in connection with this offering and will pay Ladenburg
a fee equal to $500,000. Ladenburg is neither acting as an underwriter in this offering nor obligated to purchase any of the shares
of Series 1 preferred stock offered herby. We estimate that the total expenses of this offering, excluding underwriting discounts
and commissions, will be approximately $616,500, which includes the fee we are paying to Ladenburg.
Discretionary
Accounts. The underwriters do not intend to confirm sales of the shares to any accounts over which
they have discretionary authority.
Stabilization. In
connection with this offering, the underwriters may engage in stabilizing transactions, syndicate covering transactions, penalty
bids and purchases to cover positions created by short sales.
|
●
|
Stabilizing
transactions permit bids to purchase shares of common stock so long as the stabilizing
bids do not exceed a specified maximum, and are engaged in for the purpose of preventing
or retarding a decline in the market price of the common stock while the offering is
in progress.
|
|
●
|
Syndicate
covering transactions involve purchases of common stock in the open market after the
distribution has been completed in order to cover syndicate short positions. In determining
the source of shares to close out the short position, the underwriters will consider,
among other things, the price of shares available for purchase in the open market as
compared with the price at which they purchased shares from us. If the underwriters sell
more shares than we are offering and thus have a naked short position, the position can
be closed out only by buying shares in the open market. A naked short position is more
likely to be created if the underwriters are concerned that after pricing there could
be downward pressure on the price of the shares in the open market that could adversely
affect investors who purchase in the offering.
|
|
●
|
Penalty
bids permit the representative to reclaim a selling concession from a syndicate member
when the common stock originally sold by that syndicate member is purchased in stabilizing
or syndicate covering transactions to cover syndicate short positions.
|
These
stabilizing transactions, syndicate covering transactions and penalty bids may have the effect of raising or maintaining the market
price of our common stock or preventing or retarding a decline in the market price of our common stock. As a result, the price
of our common stock in the open market may be higher than it would otherwise be in the absence of these transactions. Neither
we nor the underwriters make any representation or prediction as to the effect that the transactions described above may have
on the price of our common stock. These transactions may be effected on the Nasdaq Stock Market, in the over-the-counter market
or otherwise and, if commenced, may be discontinued at any time.
Passive
Market Making. In connection with this offering, underwriters and selling group members may engage
in passive market making transactions in our common stock on the Nasdaq Stock Market in accordance with Rule 103 of Regulation
M under the Securities Exchange Act of 1934, as amended, during a period before the commencement of offers or sales of common
stock and extending through the completion of the distribution. A passive market maker must display its bid at a price not in
excess of the highest independent bid of that security. However, if all independent bids are lowered below the passive market
maker’s bid, that bid must then be lowered when specified purchase limits are exceeded.
Lock-Up Agreements. Pursuant
to certain "lock-up” agreements, we and our executive officers, directors and certain of their affiliates have
agreed, subject to certain exceptions, not to offer, sell, assign, transfer, pledge, contract to sell, or otherwise dispose of
or announce the intention to otherwise dispose of, or enter into any swap, hedge or similar agreement or arrangement that transfers,
in whole or in part, the economic consequence of ownership of, directly or indirectly, or make any demand or request or exercise
any right with respect to the registration of, or file with the SEC a registration statement under the Securities Act relating
to, any common stock or securities convertible into or exchangeable or exercisable for any common stock without the prior written
consent of the Representatives, for a period of 90 days after the date of the pricing of the offering.
Cowen,
in its sole discretion, may release our common stock and other securities subject to the lock-up agreements described above in
whole or in part at any time. When determining whether or not to release our common stock and other securities from lock-up agreements,
Cowen will consider, among other factors, the holder’s reasons for requesting the release, the number of shares for which
the release is being requested and market conditions at the time of the request.
Canada. The
Series 1 preferred stock may be sold only to purchasers purchasing, or deemed to be purchasing, as principal, who are accredited
investors, as defined in National Instrument 45-106 Prospectus Exemptions or subsection 73.3(1) of the Securities
Act (Ontario), and are permitted clients, as defined in National Instrument 31-103 Registration Requirements,
Exemptions and Ongoing Registrant Obligations. Any resale of the Series 1 preferred stock must be made in accordance with
an exemption from, or in a transaction not subject to, the prospectus requirements of applicable securities laws.
Securities
legislation in certain provinces or territories of Canada may provide a purchaser with remedies for rescission or damages if this
prospectus supplement (including any amendment thereto) contains a misrepresentation, provided that the remedies for rescission
or damages are exercised by the purchaser within the time limit prescribed by the securities legislation of the purchaser’s
province or territory. The purchaser should refer to any applicable provisions of the securities legislation of the purchaser’s
province or territory for particulars of these rights or consult with a legal advisor.
Pursuant
to section 3A.3 of National Instrument 33-105 Underwriting Conflicts (NI 33-105), the underwriters
are not required to comply with the disclosure requirements of NI 33-105 regarding underwriter conflicts of interest
in connection with this offering.
United
Kingdom. Each of the underwriters has represented and agreed that:
|
●
|
it
has not made or will not make an offer of the securities to the public in the United
Kingdom within the meaning of section 102B of the Financial Services and Markets Act
2000 (as amended) (FSMA) except to legal entities which are authorized or regulated to
operate in the financial markets or, if not so authorized or regulated, whose corporate
purpose is solely to invest in securities or otherwise in circumstances which do not
require the publication by us of a prospectus pursuant to the Prospectus Rules of the
Financial Services Authority (FSA);
|
|
●
|
it
has only communicated or caused to be communicated and will only communicate or cause
to be communicated an invitation or inducement to engage in investment activity (within
the meaning of section 21 of FSMA) to persons who have professional experience in matters
relating to investments falling within Article 19(5) of the Financial Services and Markets
Act 2000 (Financial Promotion) Order 2005 or in circumstances in which section 21 of
FSMA does not apply to us; and
|
|
●
|
it
has complied with and will comply with all applicable provisions of FSMA with respect
to anything done by it in relation to the securities in, from or otherwise involving
the United Kingdom.
|
Switzerland. The
securities will not be offered, directly or indirectly, to the public in Switzerland and this prospectus does not constitute a
public offering prospectus as that term is understood pursuant to article 652a or 1156 of the Swiss Federal Code of Obligations.
European
Economic Area. In relation to each Member State of the European Economic Area (each, a “Member
State”), no offer of shares may be made to the public in that Member State other than:
|
(a)
|
to
any legal entity which is a qualified investor as defined in the Prospectus Regulation;
|
|
(b)
|
to
fewer than 150 natural or legal persons (other than qualified investors as defined in
the Prospectus Regulation), subject to obtaining the prior consent of the representatives;
or
|
|
(c)
|
in
any other circumstances falling within Article 1(4) of the Prospectus Regulation, provided
that no such offer of shares shall require us or any underwriter to publish a prospectus
pursuant to Article 3 of the Prospectus Regulation or supplement a prospectus pursuant
to Article 23 of the Prospectus Regulation and each person who initially acquires any
shares or to whom any offer is made will be deemed to have represented, acknowledged
and agreed to and with each of the underwriters and us that it is a “qualified
investor” as defined in the Prospectus Regulation.
|
In
the case of any shares being offered to a financial intermediary as that term is used in Article 5 of the Prospectus Regulation,
each such financial intermediary will be deemed to have represented, acknowledged and agreed that the shares acquired by it in
the offer have not been acquired on a nondiscretionary basis on behalf of, nor have they been acquired with a view to their offer
or resale to, persons in circumstances which may give rise to an offer of any shares to the public other than their offer or resale
in a Member State to qualified investors as so defined or in circumstances in which the prior consent of the underwriters has
been obtained to each such proposed offer or resale.
For
the purposes of this provision, the expression an “offer of shares to the public” in relation to any shares in any
Member State means the communication in any form and by means of sufficient information on the terms of the offer and the shares
to be offered so as to enable an investor to decide to purchase shares, and the expression “Prospectus Regulation”
means Regulation (EU) 2017/1129 (as amended).
Israel. In
the State of Israel this prospectus shall not be regarded as an offer to the public to purchase shares of Series 1 preferred stock
under the Israeli Securities Law, 5728 – 1968, which requires a prospectus to be published and authorized by the
Israel Securities Authority, if it complies with certain provisions of Section 15 of the Israeli Securities Law, 5728–1968,
including, inter alia, if: (i) the offer is made, distributed or directed to not more than 35 investors, subject to certain
conditions, or the Addressed Investors; or (ii) the offer is made, distributed or directed to certain qualified investors
defined in the First Addendum of the Israeli Securities Law, 5728 – 1968, subject to certain conditions, or the
Qualified Investors. The Qualified Investors shall not be taken into account in the count of the Addressed Investors and
may be offered to purchase securities in addition to the 35 Addressed Investors. The company has not and will not take any
action that would require it to publish a prospectus in accordance with and subject to the Israeli Securities Law, 5728 – 1968. We
have not and will not distribute this prospectus or make, distribute or direct an offer to subscribe for our Series 1 preferred
stock to any person within the State of Israel, other than to Qualified Investors and up to 35 Addressed Investors.
Qualified
Investors may have to submit written evidence that they meet the definitions set out in of the First Addendum to the Israeli Securities
Law, 5728 – 1968. In particular, we may request, as a condition to be offered Series 1 preferred stock, that
Qualified Investors will each represent, warrant and certify to us and/or to anyone acting on our behalf: (i) that it is
an investor falling within one of the categories listed in the First Addendum to the Israeli Securities Law, 5728 – 1968;
(ii) which of the categories listed in the First Addendum to the Israeli Securities Law, 5728 – 1968 regarding
Qualified Investors is applicable to it; (iii) that it will abide by all provisions set forth in the Israeli Securities Law,
5728 – 1968 and the regulations promulgated thereunder in connection with the offer to be issued Series 1 preferred
stock; (iv) that the shares of Series 1 preferred stock that it will be issued are, subject to exemptions available under
the Israeli Securities Law, 5728 – 1968: (a) for its own account; (b) for investment purposes only; and (c) not
issued with a view to resale within the State of Israel, other than in accordance with the provisions of the Israeli Securities
Law, 5728 – 1968; and (v) that it is willing to provide further evidence of its Qualified Investor status. Addressed
Investors may have to submit written evidence in respect of their identity and may have to sign and submit a declaration containing,
inter alia, the Addressed Investor’s name, address and passport number or Israeli identification number.
Electronic
Offer, Sale and Distribution of Shares. A prospectus in electronic format may be made available
on the websites maintained by one or more of the underwriters or selling group members, if any, participating in this offering
and one or more of the underwriters participating in this offering may distribute prospectuses electronically. The Representatives
may agree to allocate a number of shares to underwriters and selling group members for sale to their online brokerage account
holders. Internet distributions will be allocated by the underwriters and selling group members that will make internet distributions
on the same basis as other allocations. Other than the prospectus in electronic format, the information on these websites is not
part of this prospectus or the registration statement of which this prospectus forms a part, has not been approved or endorsed
by us or any underwriter in its capacity as underwriter, and should not be relied upon by investors.
Other
Relationships. Certain of the underwriters and their affiliates have provided, and may in the future
provide, various investment banking, commercial banking and other financial services for us and our affiliates for which they
have received, and may in the future receive, customary fees. The underwriters and certain of their affiliates may also communicate
independent investment recommendations, market color or trading ideas and/or publish or express independent research views in
respect of the Series 1 preferred stock and may at any time hold, or recommend to clients that they acquire, long and/or short positions in
the Series 1 preferred stock.
LEGAL
MATTERS
Cooley
LLP, San Diego, California, will pass upon the validity of the issuance of the securities being sold in this offering. Certain
legal matters related to this offering will be passed upon for the underwriters by Goodwin Procter LLP, New York, New York.
EXPERTS
The
consolidated financial statements of ArTara Subsidiary, Inc. (formerly ArTara Therapeutics, Inc.) as of December 31, 2019 and
2018 and for each of the years then ended, incorporated by reference in this prospectus supplement from the Company’s Current
Report on Form 8-K/A, filed with the SEC on March 20, 2020, have been audited by Marcum, LLP, an independent registered public
accounting firm, as set forth in their report, which is incorporated herein by reference. Such consolidated financial statements
have been so incorporated by reference in reliance on such report given upon such firm as experts in auditing and accounting.
The
consolidated financial statements of Protara Therapeutics, Inc. (formerly Proteon Therapeutics, Inc. and ArTara Therapeutics,
Inc.) at December 31, 2019 and 2018, and for each of the years then ended, incorporated by reference in this prospectus supplement
and registration statement have been audited by Ernst & Young LLP, independent registered public accounting firm, as set forth
in their report thereon appearing elsewhere herein, and are included in reliance upon such report given on the authority of such
firm as experts in accounting and auditing.
WHERE
YOU CAN FIND MORE INFORMATION
This
prospectus supplement and the accompanying prospectus are part of the registration statement on Form S-3 we filed with the SEC
under the Securities Act and do not contain all of the information set forth or incorporated by reference in the registration
statement and the exhibits to the registration statement. For further information with respect to us and the securities we are
offering under this prospectus supplement, we refer you to the registration statement and the exhibits and schedules filed as
a part of the registration statement.
We
must comply with the informational requirements of the Exchange Act, and we are required to file reports and proxy statements
and other information with the SEC. You may read and copy these reports, proxy statements and other information on the SEC’s
website at http://www.sec.gov, which contains reports, proxy and information statements and other information regarding issuers
like us that file electronically with the SEC. We maintain a website at www.protaratx.com. The information contained in, or that
can be accessed through, our website is not incorporated by reference herein and is not part of this prospectus.
Statements
contained in this prospectus supplement as to the contents of any contract or other document are not necessarily complete, and
in each instance we refer you to the copy of the contract or document filed as an exhibit to the registration statement, each
such statement being qualified in all respects by such reference.
INCORPORATION
OF CERTAIN INFORMATION BY REFERENCE
The
SEC allows us to “incorporate by reference” information that we file with it, which means that we can disclose important
information to you by referring you to those documents. The information incorporated by reference is an important part of this
prospectus supplement. Information in this prospectus supplement supersedes information incorporated by reference that we filed
with the SEC prior to the date of this prospectus supplement, while information that we file later with the SEC will automatically
update and supersede the information in this prospectus supplement. We also incorporate by reference into this prospectus supplement
the documents listed below and any future filings made by us with the SEC (other than current reports or portions thereof furnished
under Item 2.02 or Item 7.01 of Form 8-K and exhibits filed on such form that are related to such items and other portions of
documents that are furnished, but not filed, pursuant to applicable rules promulgated by the SEC) that are filed by us with the
SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (i) after the date of the initial filing of the registration
statement of which this prospectus supplement is a part and prior to effectiveness of the registration statement, and (ii) after
the effectiveness of the registration statement but prior to the termination of the offering of the securities covered by this
prospectus supplement:
|
●
|
our
Annual Report on Form
10-K for the fiscal year ended December 31, 2019, filed with the SEC on March 20,
2020;
|
|
●
|
the
information specifically incorporated by reference into our Annual Report on Form
10-K for the year ended December 31, 2019 from our definitive proxy statement on Schedule
14A, as filed with the SEC on April 23, 2020;
|
|
●
|
our
Quarterly Reports on Form 10-Q for the quarter ended March 31, 2020 and June 30, 2020, filed with the SEC on May
13, 2020 and July
31, 2020, respectively;
|
|
●
|
our
Current Reports on Form 8-K filed on January
10, 2020 (as amended by Amendment No. 1 thereto, filed with the SEC on March
20, 2020), February
11, 2020, March
23, 2020, March
30, 2020, June
10, 2020, July
16, 2020, July
24, 2020 and September
8, 2020; and
|
|
●
|
the
description of our common stock contained in our registration statement on Form
8-A filed with the SEC on October 16, 2014, including any amendments or reports filed
for the purposes of updating this description.
|
We
will furnish without charge to each person, including any beneficial owner, to whom this prospectus supplement and the accompanying
prospectus is delivered, upon written or oral request, a copy of any document incorporated by reference. Requests should be addressed
to 1 Little West 12th Street, New York, NY 10014, Attn: Secretary or may be made telephonically at (646) 844-0337. Copies of these
filings are filings are also available, without charge, on the SEC’s website at www.sec.gov and on our website www.protaratx.com
as soon as reasonably practicable after they are filed electronically with the SEC. The information contained on our website is
not part of this prospectus supplement or the accompanying prospectus.
In
accordance with Rule 412 of the Securities Act, any statement contained in a document incorporated by reference in this prospectus
supplement or the accompanying prospectus shall be deemed modified, superseded or replaced for the purposes of this prospectus
supplement or the accompanying prospectus to the extent that a statement contained in this prospectus supplement or the accompanying
prospectus or in any other subsequently filed document that also is or is deemed to be incorporated by reference herein modifies
or supersedes such statement.
PROSPECTUS
$150,000,000
Common Stock
Preferred Stock
Debt Securities
Warrants
From
time to time, we may offer up to $150,000,000 of any combination of the securities described in this prospectus in one or more
offerings. We may also offer securities as may be issuable upon conversion, redemption, repurchase, exchange or exercise of any
securities registered hereunder, including any applicable antidilution provisions.
This
prospectus provides a general description of the securities we may offer. Each time we offer securities, we will provide specific
terms of the securities offered in a supplement to this prospectus. We may also authorize one or more free writing prospectuses
to be provided to you in connection with these offerings. The prospectus supplement and any related free writing prospectus may
also add, update or change information contained in this prospectus. You should carefully read this prospectus, the applicable
prospectus supplement and any related free writing prospectus, as well as any documents incorporated by reference, before you
invest in any of the securities being offered.
This
prospectus may not be used to consummate a sale of any securities unless accompanied by a prospectus supplement.
Our
common stock is listed on The Nasdaq Capital Market, or Nasdaq, under the symbol “TARA.” On May 12, 2020, the last
reported sale price of our common stock was $24.60 per share. The applicable prospectus supplement will contain information, where
applicable, as to any other listing on Nasdaq or any securities market or other exchange of the securities, if any, covered by
the prospectus supplement.
We
will sell these securities directly to investors, through agents designated from time to time or to or through underwriters or
dealers, on a continuous or delayed basis. For additional information on the methods of sale, you should refer to the section
titled “Plan of Distribution” in this prospectus. If any agents or underwriters are involved in the sale of any securities
with respect to which this prospectus is being delivered, the names of such agents or underwriters and any applicable fees, commissions,
discounts or over-allotment options will be set forth in a prospectus supplement. The price to the public of such securities and
the net proceeds we expect to receive from such sale will also be set forth in a prospectus supplement.
Investing
in our securities involves a high degree of risk. You should review carefully the risks and uncertainties described under the
heading “Risk Factors” contained in the applicable prospectus supplement and any related free writing prospectus,
and under similar headings in the other documents that are incorporated by reference into this prospectus as described on page
26 of this prospectus.
Neither
the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or
determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.
The
date of this prospectus is May 26, 2020.
TABLE
OF CONTENTS
ABOUT
THIS PROSPECTUS
This
prospectus is a part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission, or SEC,
utilizing a “shelf” registration process. Under this shelf registration process, we may sell any combination of the
securities described in this prospectus in one or more offerings up to a total aggregate offering price of $150,000,000. This
prospectus provides you with a general description of the securities we may offer.
Each
time we sell securities under this prospectus, we will provide a prospectus supplement that will contain specific information
about the terms of that offering. We may also authorize one or more free writing prospectuses to be provided to you that may contain
material information relating to these offerings. The prospectus supplement and any related free writing prospectus that we may
authorize to be provided to you may also add, update or change information contained in this prospectus or in any documents that
we have incorporated by reference into this prospectus. You should read this prospectus, any applicable prospectus supplement
and any related free writing prospectus, together with the information incorporated herein by reference as described under the
heading “Incorporation of Certain Information by Reference,” before investing in any of the securities offered.
THIS
PROSPECTUS MAY NOT BE USED TO CONSUMMATE A SALE OF SECURITIES UNLESS IT IS ACCOMPANIED BY A PROSPECTUS SUPPLEMENT.
Neither
we, nor any agent, underwriter or dealer has authorized any person to give any information or to make any representation other
than those contained or incorporated by reference in this prospectus, any applicable prospectus supplement or any related free
writing prospectus prepared by or on behalf of us or to which we have referred you. This prospectus, any applicable supplement
to this prospectus or any related free writing prospectus do not constitute an offer to sell or the solicitation of an offer to
buy any securities other than the registered securities to which they relate, nor do this prospectus, any applicable supplement
to this prospectus or any related free writing prospectus constitute an offer to sell or the solicitation of an offer to buy securities
in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction.
You
should not assume that the information contained in this prospectus, any applicable prospectus supplement or any related free
writing prospectus is accurate on any date subsequent to the date set forth on the front of the document or that any information
we have incorporated by reference is correct on any date subsequent to the date of the document incorporated by reference, even
though this prospectus, any applicable prospectus supplement or any related free writing prospectus is delivered, or securities
are sold, on a later date.
This
prospectus and the information incorporated herein by reference contains summaries of certain provisions contained in some of
the documents described herein, but reference is made to the actual documents for complete information. All of the summaries are
qualified in their entirety by the actual documents. Copies of some of the documents referred to herein have been filed, will
be filed or will be incorporated by reference as exhibits to the registration statement of which this prospectus is a part, and
you may obtain copies of those documents as described below under the heading “Where You Can Find More Information.”
Unless
otherwise stated, all references in this prospectus to “we,” “us,” “our,” “Protara,”
the “Company” and similar designations refer to Protara Therapeutics, Inc. This prospectus contains references to
trademarks belonging to other entities. Solely for convenience, trademarks and trade names referred to in this prospectus, including
logos, artwork and other visual displays, may appear without the ® or ™ symbols, but such references are not intended
to indicate, in any way, that the applicable licensor will not assert, to the fullest extent under applicable law, its rights
to these trademarks and trade names. We do not intend our use or display of other companies’ trade names or trademarks to
imply a relationship with, or endorsement or sponsorship of us by, any other companies.
SUMMARY
The
following summary highlights information contained elsewhere in this prospectus. This summary is not complete and does not contain
all of the information that you need to consider in making your investment decision. You should carefully read the entire prospectus,
the applicable prospectus supplement and any related free writing prospectus, including the risks of investing in our securities
discussed under the heading “Risk Factors” contained in the applicable prospectus supplement and any related free
writing prospectus, and under similar headings in the other documents that are incorporated by reference into this prospectus.
You should also carefully read the information incorporated by reference into this prospectus, including our financial statements,
and the exhibits to the registration statement of which this prospectus is a part.
Unless
the context indicates otherwise, references in this prospectus to “Protara,” “Protara Therapeutics,” “the
Company,” “we,” “us,” “our” and similar references refer to Protara Therapeutics, Inc.
Overview
We
are a New York City based clinical-stage biopharmaceutical company focused on identifying and advancing transformative therapies
for people with rare and specialty diseases. We prioritize creativity, diverse perspectives, integrity and tenacity to expedite
our goal of bringing life-changing therapies to people with limited treatment options.
Our
lead program, TARA-002 is an investigational cell based therapy currently being developed for the treatment of lymphatic malformations,
or LMs. In addition to LMs, the Company is also evaluating the potential of TARA-002 in oncologic indications. TARA-002 was developed
from the same master cell bank of genetically distinct group A Streptococcus pyogenes as OK-432 (marketed as Picibanil® in
Japan and Taiwan by Chugai Pharmaceutical Co., Ltd., or Chugai Pharmaceutical). We plan to engage the U.S. Food and Drug Administration,
or FDA, in 2020 to determine the requirements for a biologics license application, or BLA, submission, including agreement on
requirements to demonstrate the comparability of the two products. We plan to discuss with the FDA whether OK-432’s more
than 25-year safety database in LMs, as well as the efficacy and safety database from the clinical trials conducted in the US
and led by the University of Iowa are sufficient for a BLA submission for TARA-002. Based on the guidance from the FDA, we plan
to conduct additional clinical trials as required.
Our
second program, Intravenous (IV) Choline Chloride, is an investigational, Phase 3-ready, phospholipid substrate replacement therapy
initially in development for patients receiving parenteral nutrition who have intestinal failure associated liver disease. IV
Choline Chloride has been granted Orphan Drug Designation by the FDA for this indication.
Our
third program, vonapanitase, is a recombinant human elastase. We are reviewing the research and preclinical and clinical data
of vonapanitase and have not yet determined whether to pursue further development of this product candidate in the future.
We
have devoted substantial efforts in the development of these programs. We do not have any approved products and have not generated
any revenue from product sales. The lead program, TARA-002, is in later stage development and has not yet been approved for use
for treatment of LMs or any other indications. The Company does not expect to generate any significant revenues prior to 2021,
if ever. To finance the Company’s current strategic plans, including the conduct of ongoing and future clinical trials and
further research and development costs, the Company will need to raise additional capital.
The
Merger
On
January 9, 2020, we, then known as Proteon Therapeutics, Inc., completed our previously announced merger transaction with ArTara
Subsidiary, Inc. (formerly ArTara Therapeutics, Inc., or Private ArTara) in accordance with the terms of the Agreement and Plan
of Merger and Reorganization, or the Merger Agreement, dated as of September 23, 2019, by and among the Company, REM 1 Acquisition,
Inc., and Private ArTara, pursuant to which REM 1 Acquisition, Inc. merged with and into Private ArTara, with Private ArTara surviving
as a wholly owned subsidiary of the Company, which we refer to as the “Merger”.
On
January 9, 2020, in connection with, and prior to the completion of, the Merger, we effected a 1-for-40 reverse stock split of
our common stock, Private ArTara changed its name from “ArTara Therapeutics, Inc.” to “ArTara Subsidiary, Inc.”,
and we changed our name from “Proteon Therapeutics, Inc.” to “ArTara Therapeutics, Inc.” On May 11, 2020,
we changed our name from “ArTara Therapeutics, Inc.” to “Protara Therapeutics, Inc.”
Corporate
Information
We
were originally incorporated in March 2006 in the State of Delaware under the name Proteon Therapeutics, Inc., and at that time,
acquired Proteon Therapeutics, LLC, our predecessor, which was formed in June 2001. In January 2020, we effected a reverse merger,
pursuant to which a wholly owned subsidiary of ours merged with and into Private ArTara, with Private ArTara surviving as a wholly
owned subsidiary of ours. In January 2020, we changed our name from Proteon Therapeutics, Inc. to ArTara Therapeutics, Inc., and
in May 2020, we changed our name from ArTara Therapeutics, Inc. to Protara Therapeutics, Inc. Our principal executive offices
are located at 1 Little West 12th Street, New York, New York 10014, our telephone number is (646) 844-0337 and our website address
is www.protaratx.com. The information contained in or accessible through our website does not constitute part of this prospectus.
The
Securities We May Offer
We
may offer shares of our common stock and preferred stock, various series of debt securities and warrants to purchase any of such
securities, up to a total aggregate offering price of $150,000,000 from time to time in one or more offerings under this prospectus,
together with any applicable prospectus supplement and any related free writing prospectus, at prices and on terms to be determined
by market conditions at the time of the relevant offering. This prospectus provides you with a general description of the securities
we may offer. Each time we offer a type or series of securities under this prospectus, we will provide a prospectus supplement
that will describe the specific amounts, prices and other important terms of the securities, including, to the extent applicable:
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designation or classification;
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aggregate principal
amount or aggregate offering price;
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maturity, if applicable;
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original issue discount,
if any;
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rates
and times of payment of interest or dividends, if any;
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redemption,
conversion, exchange or sinking fund terms, if any;
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ranking,
if applicable;
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restrictive
covenants, if any;
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voting
or other rights, if any;
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conversion
or exchange prices or rates, if any, and, if applicable, any provisions for changes to or adjustments in the conversion or
exchange prices or rates and in the securities or other property receivable upon conversion or exchange; and
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important
U.S. federal income tax considerations.
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The
prospectus supplement and any related free writing prospectus that we may authorize to be provided to you may also add, update
or change information contained in this prospectus or in documents we have incorporated by reference. However, no prospectus supplement
or free writing prospectus will offer a security that is not registered and described in this prospectus at the time of the effectiveness
of the registration statement of which this prospectus is a part.
We
may sell the securities directly to investors or through underwriters, dealers or agents. We, and our underwriters or agents,
reserve the right to accept or reject all or part of any proposed purchase of securities. If we do offer securities through underwriters
or agents, we will include in the applicable prospectus supplement:
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the
names of those underwriters or agents;
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applicable
fees, discounts and commissions to be paid to them;
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details
regarding over-allotment options, if any; and
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the
estimated net proceeds to us.
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This
prospectus may not be used to consummate a sale of securities unless it is accompanied by a prospectus supplement.
Common
Stock. We may issue shares of our common stock from time to time. Each holder of common stock is entitled to one vote
for each share on all matters submitted to a vote of the stockholders and does not have cumulative voting rights. Subject to preferences
that may apply to any outstanding preferred stock, holders of our common stock are entitled to receive ratably any dividends that
our board of directors may declare out of funds legally available for that purpose. In the
event of our liquidation, dissolution or winding up, holders of our common stock are entitled to share ratably in all assets remaining
after payment of liabilities and the liquidation preference of any outstanding preferred stock. Holders
of our common stock have no preemptive, conversion, subscription or other rights, and there are no redemption or sinking fund
provisions applicable to our common stock. The rights, preferences and privileges of the holders of our common stock are subject
to and may be adversely affected by the rights of the holders of shares of any series of our preferred stock that we may designate
in the future, as well as our Series 1 Convertible Non-Voting Preferred Stock, or Series 1 Preferred Stock. In this prospectus,
we have summarized certain general features of our common stock under the heading “Description of Capital Stock—Common
Stock.” We urge you, however, to read the applicable prospectus supplement (and any related free writing prospectus that
we may authorize to be provided to you) related to any common stock being offered.
Preferred
Stock. We may issue shares of our preferred stock from time to time, in one or more series. Under our amended and restated
certificate of incorporation, our board of directors has the authority, without further
action by our stockholders (unless such stockholder action is required by applicable law or the rules of any stock exchange or
market on which our securities are then traded), to issue up to 10,000,000 shares of preferred stock in one or more series and
to fix the number, rights, preferences, privileges and restrictions thereof. These rights, preferences and privileges could include
dividend rights, conversion rights, voting rights, terms of redemption, liquidation preferences and sinking fund terms, and the
number of shares constituting any series or the designation of such series, any or all of which may be greater than the rights
of common stock. Any convertible preferred stock we may issue will be convertible into our common stock or exchangeable
for our other securities. Conversion may be mandatory or at the holder’s option and would be at prescribed conversion rates.
If
we sell any series of preferred stock under this prospectus, we will fix the designations, voting powers, preferences and rights
of such series of preferred stock, as well as the qualifications, limitations or restrictions thereof, in the certificate of designation
relating to that series. We will file as an exhibit to the registration statement of which this prospectus is a part, or will
incorporate by reference from reports that we file with the SEC, the form of any certificate of designation that describes the
terms of the series of preferred stock that we are offering before the issuance of the related series of preferred stock. In this
prospectus, we have summarized certain general features of the preferred stock under the heading “Description of Capital
Stock—Preferred Stock.” We urge you, however, to read the applicable prospectus supplement (and any free writing
prospectus that we may authorize to be provided to you) related to the series of preferred stock being offered, as well as the
complete certificate of designation that contains the terms of the applicable series of preferred stock.
Debt
Securities. From time to time, we may issue debt securities in one or more series, as either senior or subordinated debt
or as senior or subordinated convertible debt. The senior debt securities will rank equally with any other unsecured and unsubordinated
debt. The subordinated debt securities will be subordinate and junior in right of payment, to the extent and in the manner described
in the instrument governing the debt, to all of our senior indebtedness. Convertible debt securities will be convertible into
or exchangeable for our common stock or other securities. Conversion may be mandatory or at the holder’s option and would
be at prescribed conversion rates.
Any
debt securities issued under this prospectus will be issued under one or more documents called indentures, which are contracts
between us and a national banking association or other eligible party, as trustee. In this prospectus, we have summarized certain
general features of the debt securities under the heading “Description of Debt Securities.” We urge you, however,
to read the applicable prospectus supplement (and any free writing prospectus that we may authorize to be provided to you) related
to the series of debt securities being offered, as well as the complete indenture(s) and any supplemental indentures that contain
the terms of the debt securities. We have filed a form of indenture as an exhibit to the registration statement of which this
prospectus is a part. We will file as exhibits to the registration statement of which this prospectus is a part, or will be incorporated
by reference from reports that we file with the SEC, supplemental indentures and forms of debt securities containing the terms
of the debt securities being offered.
Warrants.
From time to time, we may issue warrants for the purchase of common stock, preferred stock and/or debt securities, in
one or more series, from time to time. We may issue warrants independently or in combination with common stock, preferred stock
and/or debt securities, and the warrants may be attached to or separate from these securities. In this prospectus, we have summarized
certain general features of the warrants under the heading “Description of Warrants.” We urge you, however, to read
the applicable prospectus supplement (and any free writing prospectus that we may authorize to be provided to you) related to
the particular series of warrants being offered, as well as the complete warrant agreements and warrant certificates that contain
the terms of the warrants. We have filed forms of the warrant agreements and forms of warrant certificates containing the terms
of the warrants that we may offer as exhibits to the registration statement of which this prospectus is a part. We will file as
exhibits to the registration statement of which this prospectus is a part, or will be incorporated by reference from reports that
we file with the SEC, the form of warrant or the warrant agreement and warrant certificate, as applicable, that contain the terms
of the particular series of warrants we are offering, and any supplemental agreements, before the issuance of such warrants.
Any
warrants issued under this prospectus may be evidenced by warrant certificates. Warrants may be issued under a warrant agreement
that we enter into with a warrant agent. We will indicate the name and address of the warrant agent, if applicable, in the prospectus
supplement relating to the particular series of warrants being offered.
RISK
FACTORS
Investing
in our securities involves a high degree of risk. You should carefully review the risks and uncertainties described under the
heading “Risk Factors” contained in the applicable prospectus supplement and any related free writing prospectus,
and under similar headings in our Annual Report on Form 10-K for the year ended December 31, 2019, as updated by our annual, quarterly
and other reports and documents that are incorporated by reference into this prospectus, before deciding whether to purchase any
of the securities being registered pursuant to the registration statement of which this prospectus is a part. Each of the risk
factors could adversely affect our business, results of operations, financial condition and cash flows, as well as adversely affect
the value of an investment in our securities, and the occurrence of any of these risks might cause you to lose all or part of
your investment. Additional risks not presently known to us or that we currently believe are immaterial may also significantly
impair our business operations.
SPECIAL
NOTE REGARDING FORWARD-LOOKING STATEMENTS
This
prospectus, including the information incorporated herein by reference, contains, and any prospectus supplement may contain, forward-looking
statements. These statements are based on our management’s current beliefs, expectations and assumptions about future events,
conditions and results and on information currently available to us. Discussions containing these forward-looking statements may
be found, among other places, in the sections titled “Business,” “Risk Factors” and “Management’s
Discussion and Analysis of Financial Condition and Results of Operations” incorporated by reference from our most recent
Annual Report on Form 10-K and our most recent Quarterly Report on Form 10-Q, as well as any amendments thereto, filed with the
SEC.
In
some cases, you can identify forward-looking statements by terminology such as “aim,” “anticipate,” “assume,”
“believe,” “contemplate,” “continue,” “could,” “design,” “due,”
“estimate,” “expect,” “goal,” “intend,” “may,” “objective,”
“plan,” “predict,” “positioned,” “potential,” “seek,” “should,”
“target,” “will,” “would” or the negative or plural of those terms, and similar expressions
intended to identify statements about the future, although not all forward-looking statements contain these words. These forward-looking
statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity,
performance or achievements to be materially different from the information expressed or implied by these statements.
Any
statements in this prospectus, or incorporated herein by reference, about our expectations, beliefs, plans, objectives, assumptions
or future events or performance are not historical facts and are forward-looking statements. Within the meaning of Section 27A
of the Securities Act and Section 21E of the Exchange Act these forward-looking statements include statements regarding:
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the
impact of the COVID-19 pandemic on our business and operations as well as the business or operations of our manufacturers,
research partners, and other third parties with whom we conduct business or regulatory agencies;
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estimates
regarding our financial performance, including future revenue, expenses and capital requirements
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our
expected cash position and ability to obtain financing in the future on satisfactory terms or at all;
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expectations
regarding our plans to research, develop and commercialize our current and future product candidates, including TARA-002,
and Intravenous (IV) Choline Chloride;
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expectations
regarding the safety and efficacy of our product candidates;
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expectations
regarding the timing, costs and outcomes of our planned clinical trials;
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expectations
regarding potential market size;
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expectations
regarding the timing of the availability of data from our clinical trials
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expectations
regarding the clinical utility, potential benefits and market acceptance of our product candidates;
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expectations
regarding our commercialization, marketing and manufacturing capabilities and strategy;
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the
implementation of our business model, strategic plans for our business, product candidates and technology;
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expectations
regarding our ability to identify additional products or product candidates with significant commercial potential;
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developments
and projections relating to the combined our competitors and industry;
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our
ability to remain listed on the Nasdaq Capital Market;
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the
impact of government laws and regulations;
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the
timing or likelihood of regulatory filings and approvals;
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our
ability to protect our intellectual property position; and
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our
expected use of proceeds from any offering under this prospectus.
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You
should refer to the “Risk Factors” section contained in the applicable prospectus supplement and any related free
writing prospectus, and under similar headings in the other documents that are incorporated by reference into this prospectus,
for a discussion of important factors that may cause our actual results to differ materially from those expressed or implied by
our forward-looking statements. Given these risks, uncertainties and other factors, many of which are beyond our control, we cannot
assure you that the forward-looking statements in this prospectus will prove to be accurate, and you should not place undue reliance
on these forward-looking statements. Furthermore, if our forward-looking statements prove to be inaccurate, the inaccuracy may
be material. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements
as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time
frame, or at all.
Except
as required by law, we assume no obligation to update these forward-looking statements publicly, or to revise any forward-looking
statements to reflect events or developments occurring after the date of this prospectus, even if new information becomes available
in the future.
USE
OF PROCEEDS
We
will retain broad discretion over the use of the net proceeds from the sale of the securities offered hereby. Except as described
in any applicable prospectus supplement or in any related free writing prospectus that we may authorize to be provided to you
in connection with a specific offering, we currently intend to use the net proceeds from the sale of the securities offered hereby,
if any, for general corporate purposes, including research and development expenses, general
and administrative expenses, sales and marketing expenses, capital expenditures, which may include costs of funding future license
agreements, acquisitions, and working capital or for any other purpose we describe in the applicable prospectus supplement.
We will set forth in the applicable prospectus supplement or free writing prospectus our intended use for the net proceeds received
from the sale of any securities sold pursuant to the prospectus supplement or free writing prospectus. Pending the use of net
proceeds, we plan to invest the net proceeds in short- and intermediate-term interest-bearing
obligations, investment-grade securities, certificates of deposit or government securities.
DESCRIPTION
OF CAPITAL STOCK
The
following summary description of our capital stock is based on the provisions of our amended and restated certificate of incorporation,
as well as our amended and restated bylaws and the applicable provisions of the Delaware General Corporation Law. This information
is qualified entirely by reference to the applicable provisions of our amended certificate of incorporation, amended and restated
bylaws and the Delaware General Corporation Law. For information on how to obtain copies of our amended certificate of incorporation
and amended and restated bylaws, which are exhibits to the registration statement of which this prospectus is a part, see “Where
You Can Find Additional Information.” We refer in this section to our amended and restated certificate of incorporation
and our amended and restated bylaws as our “certificate of incorporation” and our “bylaws”, respectively.
General
Our
authorized capital stock consists of 110,000,000 shares, all with a par value of $0.001 per share, of which 100,000,000 shares
are designated as common stock and 10,000,000 shares are designated as preferred stock. As of May 12, 2020, we had 5,843,203 shares
of common stock and 3,879.356 shares of Series 1 Preferred Stock outstanding.
Common
Stock
Voting
Rights
Each
holder of our common stock is entitled to one vote for each share on all matters submitted to a vote of the stockholders, including
the election of directors. Our stockholders do not have cumulative voting rights in the election of directors. An election of
directors by our stockholders shall be determined by a plurality of votes cast by the stockholders entitled to vote on the election.
Dividends
Subject
to preferences that may be applicable to any then outstanding preferred stock, holders of our common stock are entitled to receive
dividends, if any, as may be declared from time to time by the board of directors out of legally available funds.
Liquidation
In
the event of our liquidation, dissolution or winding up, holders of our common stock will be entitled to share ratably in the
net assets legally available for distribution to stockholders after the payment of all of our debts and other liabilities and
the satisfaction of any liquidation preference granted to the holders of any then outstanding shares of preferred stock.
Rights
and Preferences
Holders
of common stock have no preemptive, conversion or subscription rights and there are no redemption or sinking fund provisions applicable
to the common stock. The rights, preferences and privileges of the holders of common stock are subject to, and may be adversely
affected by, the rights of the holders of shares of any series of preferred stock that we may designate in the future.
Preferred
Stock
Under
our certificate of incorporation, our board of directors has the authority, without further action by stockholders, to designate
up to 10,000,000 shares of preferred stock in one or more series and to fix or alter, from time to time, the powers, designations,
preferences, and relative, participating, optional, or other special rights, if any, and such qualifications and restrictions,
if any, of any series of preferred stock, including dividend rights, dividend rate, conversion rights, voting rights, rights and
terms of redemption (including sinking fund provisions), redemption price or prices, and the liquidation preference of any wholly
unissued series of preferred stock, any or all of which may be greater than the rights of the common stock, and to establish the
number of shares constituting any such series. Our board of directors has designated 3,880 shares of preferred stock as Series
1 Preferred Stock.
Our
board of directors will fix the rights, preferences, privileges, qualifications and restrictions of the preferred stock of each
series that we sell under this prospectus and any applicable prospectus supplements in the certificate of designation relating
to each such series. We will incorporate by reference as an exhibit to the registration statement of which this prospectus is
a part or as an exhibit to one or more Current Reports on Form 8-K, the form of any certificate of designation that describes
the terms of the series of preferred stock we are offering before the issuance of the related series of preferred stock. This
description will include:
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the
title and stated value;
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the
number of shares we are offering;
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the
liquidation preference per share;
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the
purchase price per share;
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the
dividend rate per share, dividend period, payment date or dates and method of calculation for dividends;
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whether
dividends will be cumulative or non-cumulative and, if cumulative, the date from which dividends will accumulate;
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our
right, if any, to defer payment of dividends and the maximum length of any such deferral period;
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the
procedures for any auction and remarketing, if any;
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the
provisions for a sinking fund, if any;
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the
provisions for redemption or repurchase, if applicable, and any restrictions on our ability to exercise those redemption and
repurchase rights;
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any
listing of the preferred stock on any securities exchange or market;
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whether
the preferred stock will be convertible into our common stock or other securities of ours, including warrants, and, if applicable,
the conversion price, or how it will be calculated, and under what circumstances and the mechanism by which it may be adjusted,
and the conversion period;
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whether
the preferred stock will be exchangeable into debt securities or other securities of ours, and, if applicable, the exchange
price, or how it will be calculated, and under what circumstances it may be adjusted, and the exchange period;
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preemptive
rights, if any;
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restrictions
on transfer, sale or other assignment, if any;
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whether
interests in the preferred stock will be represented by depositary shares;
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a
discussion of any material or special U.S. federal income tax considerations applicable to the preferred stock;
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the
relative ranking and preferences of the preferred stock as to dividend rights and rights if we liquidate, dissolve or wind
up our affairs;
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any
limitations on issuances of any class or series of preferred stock ranking senior to or on parity with the series of preferred
stock being issued as to dividend rights and rights if we liquidate, dissolve or wind up our affairs; and;
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any
other specific terms, rights, preferences, privileges, qualifications or limitations of, or restrictions on the preferred
stock.
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If
we issue and sell shares of preferred stock pursuant to this prospectus, together with any applicable prospectus supplement or
free writing prospectus, the shares will be fully paid and nonassessable.
The
laws of the state of Delaware, the state of our incorporation, provide that the holders of preferred stock will have the right
to vote separately, as a class, on any proposal involving fundamental changes in the rights of holders of such preferred stock.
This right is in addition to any voting rights that may be provided for in the applicable certificate of designation.
The
issuance of preferred stock could adversely affect the voting power, conversion or other rights of holders of common stock and
reduce the likelihood that common stockholders will receive dividend payments and payments upon liquidation. Preferred stock could
be issued quickly with terms designed to delay, deter or prevent a change in control of our company or make removal of management
more difficult. Additionally, the issuance of preferred stock may have the effect of decreasing the market price of our common
stock.
Series
1 Convertible Non-Voting Preferred Stock
On
September 23, 2019, we entered into a subscription agreement, or the Subscription Agreement, with certain institutional investors,
or the Purchasers, providing for the issuance and sale of 1,896,888 shares of common stock and 3,879.356 shares of Series 1 Preferred
Stock for an aggregate purchase price of approximately $40.5 million. The Subscription Agreement was subsequently amended by a
First Amendment to Subscription Agreement on November 19, 2019.
Each
share of Series 1 Preferred Stock is convertible, at any time at the option of the holder thereof, into 1,000 shares of common
stock, subject to a 9.99% blocker provision. Upon written notice to us, the holder may from time to time increase or decrease
such limitation to any other percentage not in excess of 19.99% specified in such notice. Each share of Series 1 Preferred Stock
is entitled to a preference of $10.00 per share upon liquidation of the Company, and thereafter will share ratably in any distributions
or payments on an as-converted basis with the holders of common stock. In addition, upon the occurrence of certain transactions
that involve the merger or consolidation of the Company, an exchange or tender offer, a sale of all or substantially all of the
assets of the Company or a reclassification of its common stock, each share of Series 1 Preferred Stock will be convertible into
the kind and amount of securities, cash and/or other property that the holder of a number of shares of common stock issuable upon
conversion of one share of Series 1 Preferred Stock would receive in connection with such transaction. Except as provided in the
Certificate of Designation or as required by law, the shares of Series 1 Preferred Stock have no voting rights.
Pursuant
to the Subscription Agreement, certain holders of Series 1 Preferred Stock have preemptive rights to participate pro rata in future
equity financings of the Company, subject to certain exceptions and limitations. In addition, the lead Purchaser has the right
(but not the obligation) to appoint up to two directors to our board of directors and one other Purchaser has the right (but not
the obligation) to appoint one director to our board of directors, in each case subject to requirements related to holding minimum
amounts of our equity securities. In addition, at any time when it does not have a designee serving on the board of directors,
each of these Purchasers has a right to designate an individual to be present and participate in a non-voting capacity in all
meetings of our board of directors and committees of the board. Further, we have also agreed not to take certain actions related
to the business without the consent of the lead Purchaser for so long as such lead Purchaser continues to hold a minimum amount
of the Series 1 Preferred Stock purchased under the Subscription Agreement. These actions include (a) liquidating, dissolving
or winding-up the affairs of the Company; (b) any merger, consolidation or other Fundamental Transaction (defined in the Subscription
Agreement); (c) amendments to our certificate of incorporation or bylaws in a manner that adversely effects the Series 1 Preferred
Stock and that is disproportionate to the effect on any other class or series of capital stock; (d) material changes to the principal
business of the Company; (e) purchases, redemptions or the payment of dividends on any capital stock (subject to certain exceptions);
(f) the sale, assignment, license or pledge of TARA-002; and (g) transactions involving assets of the Company with an aggregate
value over $2.5 million.
Concurrently
with the execution of the Subscription Agreement, we entered into a registration rights agreement, or the Registration Rights
Agreement, dated September 23, 2019, with the Purchasers. Pursuant to the terms of the Registration Rights Agreement, we prepared
and filed a registration statement on Form S-3 on January 30, 2020 for the purposes of registering the resale of the shares of
common stock issued pursuant to the Subscription Agreement and the shares of common stock issuable upon conversion of the Series
1 Preferred Stock issued pursuant to the Subscription Agreement. Additionally, pursuant to the Subscription Agreement, if at any
time after 180 days following the date of closing of the issuance and sale of Series 1 Preferred Stock and common stock pursuant
to the Subscription Agreement, either the lead Purchaser or another Purchaser determines that it may be deemed to be an “affiliate”
of the Company within the meaning of Rule 144 of the Securities Act, we shall enter into a registration rights agreement with
such Purchaser requiring us to file a registration statement on Form S-3 pursuant to a demand by such Purchaser in connection
with the resale of such Purchaser’s shares of common stock.
The
preceding summaries do not purport to be complete and are qualified in their entirety by reference to the Certificate of Designation
for the Series 1 Preferred Stock, the Registration Rights Agreement and the Subscription Agreement, as applicable, copies of which
are attached hereto as Exhibits 3.5, 4.5 and 10.1, respectively, and which are incorporated herein by reference
Delaware
Anti-Takeover Law and Provisions of Our Certificate of Incorporation, as amended, and Bylaws, as amended
Our
certificate of incorporation and our bylaws contain certain provisions that could have the effect of delaying, deterring or preventing
another party from acquiring control of us, and therefore could adversely affect the market price of our common stock. These provisions
and certain provisions of Delaware General Corporation Law, or the DGCL, which are summarized below, may also discourage coercive
takeover practices and inadequate takeover bids, and are designed, in part, to encourage persons seeking to acquire control of
us to negotiate first with our board of directors. We believe that the benefits of increased protection of our potential ability
to negotiate more favorable terms with an unfriendly or unsolicited acquirer outweigh the disadvantages of potentially discouraging
a proposal to acquire us.
Delaware
Anti-Takeover Law
We
are subject to Section 203 of the DGCL, or Section 203. Section 203 generally prohibits a public Delaware corporation
from engaging in a “business combination” with an “interested stockholder” for a period of three years
following the time that such stockholder became an interested stockholder, unless:
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prior
to such time the board of directors of the corporation approved either the business combination or the transaction which resulted
in the stockholder becoming an interested stockholder;
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upon
consummation of the transaction which resulted in the stockholder becoming an interested stockholder, the interested stockholder
owned at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding for
purposes of determining the voting stock outstanding (but not the outstanding voting stock owned by the interested stockholder)
those shares owned (i) by persons who are directors and also officers and (ii) employee stock plans in which employee
participants do not have the right to determine confidentially whether shares held subject to the plan will be tendered in
a tender or exchange offer; or
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at
or subsequent to such time the business combination is approved by the board of directors and authorized at an annual or special
meeting of stockholders, and not by written consent, by the affirmative vote of at least 66 2/3% of the outstanding voting
stock which is not owned by the interested stockholder.
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Section 203
defines a business combination to include:
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any
merger or consolidation involving the corporation and the interested stockholder;
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any
sale, transfer, pledge or other disposition involving the interested stockholder of 10% or more of the assets of the corporation;
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subject
to exceptions, any transaction that results in the issuance or transfer by the corporation of any stock of the corporation
to the interested stockholder;
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subject
to exceptions, any transaction involving the corporation that has the effect of increasing the proportionate share of the
stock of any class or series of the corporation beneficially owned by the interested stockholder; and
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the
receipt by the interested stockholder of the benefit of any loans, advances, guarantees, pledges or other financial benefits
provided by or through the corporation.
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In
general, Section 203 defines an interested stockholder as any entity or person beneficially owning 15% or more of the outstanding
voting stock of the corporation and any entity or person affiliated with or controlling or controlled by the entity or person.
Certificate
of Incorporation and Bylaws
Our
certificate of incorporation and bylaws contain certain provisions that are intended to enhance the likelihood of continuity and
stability in the composition of the board of directors and which may have the effect of delaying, deferring or preventing a future
takeover or change in control unless such takeover or change in control is approved by the board of directors. In addition,
the authorization of undesignated preferred stock makes it possible for our board of directors to issue preferred stock with voting
or other rights or preferences that could impede the success of any attempt to change our control. These provisions include:
Classified
board of directors
Our
certificate of incorporation provides that the board of directors is divided into three classes of directors, with the classes
as nearly equal in number as possible. Any additional directorships resulting from an increase in the number of directors will
be apportioned by the board of directors among the three classes. The classification of directors will have the effect of making
it more difficult for stockholders to change the composition of the board of directors.
Our
certificate of incorporation provides that, subject to any rights of holders of preferred stock to elect additional directors
under specified circumstances, the number of directors will be fixed exclusively pursuant to a resolution adopted by the board
of directors. Any additional directorships resulting from an increase in the number of directors will be distributed among the
three classes so that, as nearly as possible, each class shall consist of one third of the board of directors.
Action
by Written Consent; Special Meetings of Stockholders
Our
certificate of incorporation provides that stockholder action can be taken only at an annual or special meeting of stockholders
and cannot be taken by written consent in lieu of a meeting. Our certificate of incorporation and bylaws also provide that, except
as otherwise required by law, special meetings of the stockholders can be called only by or at the direction of the board of directors
pursuant to a resolution adopted by a majority of the total number of directors. Except as described above, stockholders will
not be permitted to call a special meeting or to require the board of directors to call a special meeting.
Removal
of Directors
Our
certificate of incorporation provides that our directors may be removed only for cause by the affirmative vote of at least 75%
of the voting power of our outstanding shares of capital stock, voting together as a single class and entitled to vote in the
election of directors. This requirement of a supermajority vote to remove directors could enable a minority of our stockholders
to prevent a change in the composition of the board of directors.
Advance
Notice Procedures
Our
bylaws include an advance notice procedure for stockholder proposals to be brought before an annual meeting of our stockholders,
including proposed nominations of persons for election to the board of directors. Stockholders at an annual meeting will only
be able to consider proposals or nominations specified in the notice of meeting or brought before the meeting by or at the direction
of the board of directors or by a stockholder who was a stockholder of record on the record date for the meeting, who is entitled
to vote at the meeting and who has given our Secretary timely written notice, in proper form, of the stockholder’s intention
to bring that business before the meeting. Although the bylaws do not give the board of directors the power to approve or disapprove
stockholder nominations of candidates or proposals regarding other business to be conducted at a special or annual meeting, the
bylaws may have the effect of precluding the conduct of certain business at a meeting if the proper procedures are not followed
or may discourage or deter a potential acquirer from conducting a solicitation of proxies to elect its own slate of directors
or otherwise attempting to obtain control of us.
Super
Majority Approval Requirements
The
Delaware General Corporation Law generally provides that the affirmative vote of a majority of the shares entitled to vote on
any matter is required to amend a corporation’s certificate of incorporation or bylaws, unless either a corporation’s
certificate of incorporation or bylaws requires a greater percentage. Our certificate of incorporation and bylaws provide that
the affirmative vote of holders of at least 75% of the outstanding shares of capital stock, voting together as a single class
and entitled to vote in the election of directors will be required to amend, alter, change or repeal the bylaws and the certificate
of incorporation. This requirement of a supermajority vote to approve amendments to our bylaws could enable a minority of our
stockholders to exercise veto power over any such amendments.
Authorized
but Unissued Shares
Our
authorized but unissued shares of common stock will be available for future issuance without stockholder approval. These additional
shares may be utilized for a variety of corporate purposes, including future public offerings to raise additional capital, corporate
acquisitions and employee benefit plans. The existence of authorized but unissued shares of common stock could render more difficult
or discourage an attempt to obtain control of a majority of our common stock by means of a proxy contest, tender offer, merger
or otherwise.
Exclusive
Forum
Our
certificate of incorporation provides that, subject to limited exceptions, the state or federal courts located in the State of
Delaware will be the sole and exclusive forum for (i) any derivative action or proceeding brought on our behalf, (ii) any action
asserting a claim of breach of a fiduciary duty owed by any of our directors, officers or other employees to us or our stockholders,
(iii) any action asserting a claim against us arising pursuant to any provision of the Delaware General Corporation Law, our certificate
of incorporation or our bylaws, or (iv) any other action asserting a claim against our that is governed by the internal affairs
doctrine; provided, that these provisions will not apply to actions or proceedings brought to enforce a duty or liability created
by the Securities Act, the Securities Exchange Act of 1934, as amended, or the Exchange Act, or any other claim for which the
federal courts have exclusive jurisdiction. Any person or entity purchasing or otherwise acquiring any interest in shares of our
capital stock shall be deemed to have notice of and to have consented to the provisions of our certificate of incorporation described
above. Although we believes these provisions benefit us by providing increased consistency in the application of Delaware law
for the specified types of actions and proceedings, the provisions may have the effect of discouraging lawsuits against our directors
and officers. The enforceability of similar choice of forum provisions in other companies’ certificates of incorporation
has been challenged in legal proceedings, and it is possible that, in connection with one or more actions or proceedings described
above, a court could find the choice of forum provisions contained in our certificate of incorporation to be inapplicable or unenforceable.
Transfer
Agent and Registrar
The
transfer agent and registrar for our common stock is Computershare Trust Company, N.A.
Listing
Our
common stock is listed on the Nasdaq Capital Market under the symbol “TARA.”
DESCRIPTION
OF DEBT SECURITIES
We
may issue debt securities from time to time, in one or more series, as either senior or subordinated debt or as senior or subordinated
convertible debt. While the terms we have summarized below will apply generally to any debt securities that we may offer under
this prospectus, we will describe the particular terms of any debt securities that we may offer in more detail in the applicable
prospectus supplement. The terms of any debt securities offered under a prospectus supplement may differ from the terms described
below. Unless the context requires otherwise, whenever we refer to the indenture, we also are referring to any supplemental indentures
that specify the terms of a particular series of debt securities.
We
will issue the debt securities under the indenture that we will enter into with the trustee named in the indenture. The indenture
will be qualified under the Trust Indenture Act of 1939, as amended, or the Trust Indenture Act. We have filed the form of indenture
as an exhibit to the registration statement of which this prospectus is a part, and supplemental indentures and forms of debt
securities containing the terms of the debt securities being offered will be filed as exhibits to the registration statement of
which this prospectus is a part, or will be incorporated by reference from, reports that we file with the SEC.
The
following summary of material provisions of the debt securities and the indenture is subject to, and qualified in its entirety
by reference to, all of the provisions of the indenture applicable to a particular series of debt securities. We urge you to read
the applicable prospectus supplements and any related free writing prospectuses related to the debt securities that we may offer
under this prospectus, as well as the complete indenture that contains the terms of the debt securities.
General
The
indenture does not limit the amount of debt securities that we may issue. It provides that we may issue debt securities up to
the principal amount that we may authorize and may be in any currency or currency unit that we may designate. Except for the limitations
on consolidation, merger and sale of all or substantially all of our assets contained in the indenture, the terms of the indenture
do not contain any covenants or other provisions designed to give holders of any debt securities protection against changes in
our operations, financial condition or transactions involving us.
We
may issue the debt securities issued under the indenture as “discount securities,” which means they may be sold at
a discount below their stated principal amount. These debt securities, as well as other debt securities that are not issued at
a discount, may be issued with “original issue discount,” or OID, for U.S. federal income tax purposes because of
interest payment and other characteristics or terms of the debt securities. Material U.S. federal income tax considerations applicable
to debt securities issued with OID will be described in more detail in any applicable prospectus supplement.
We
will describe in the applicable prospectus supplement the terms of the series of debt securities being offered, including:
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the
title of the series of debt securities;
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any
limit upon the aggregate principal amount that may be issued;
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the
maturity date or dates;
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the
form of the debt securities of the series;
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the
applicability of any guarantees;
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whether
or not the debt securities will be secured or unsecured, and the terms of any secured debt;
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whether
the debt securities rank as senior debt, senior subordinated debt, subordinated debt or any combination thereof, and the terms
of any subordination;
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if
the price (expressed as a percentage of the aggregate principal amount thereof) at which such debt securities will be issued
is a price other than the principal amount thereof, the portion of the principal amount thereof payable upon declaration of
acceleration of the maturity thereof, or if applicable, the portion of the principal amount of such debt securities that is
convertible into another security or the method by which any such portion shall be determined;
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the
interest rate or rates, which may be fixed or variable, or the method for determining the rate and the date interest will
begin to accrue, the dates interest will be payable and the regular record dates for interest payment dates or the method
for determining such dates;
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our
right, if any, to defer payment of interest and the maximum length of any such deferral period;
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if
applicable, the date or dates after which, or the period or periods during which, and the price or prices at which, we may,
at our option, redeem the series of debt securities pursuant to any optional or provisional redemption provisions and the
terms of those redemption provisions;
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the
date or dates, if any, on which, and the price or prices at which we are obligated, pursuant to any mandatory sinking fund
or analogous fund provisions or otherwise, to redeem, or at the holder’s option to purchase, the series of debt securities
and the currency or currency unit in which the debt securities are payable;
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the
denominations in which we will issue the series of debt securities, if other than denominations of $1,000 and any integral
multiple thereof;
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any
and all terms, if applicable, relating to any auction or remarketing of the debt securities of that series and any security
for our obligations with respect to such debt securities and any other terms which may be advisable in connection with the
marketing of debt securities of that series;
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whether
the debt securities of the series shall be issued in whole or in part in the form of a global security or securities; the
terms and conditions, if any, upon which such global security or securities may be exchanged in whole or in part for other
individual securities; and the depositary for such global security or securities;
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if
applicable, the provisions relating to conversion or exchange of any debt securities of the series and the terms and conditions
upon which such debt securities will be so convertible or exchangeable, including the conversion or exchange price, as applicable,
or how it will be calculated and may be adjusted, any mandatory or optional (at our option or the holders’ option) conversion
or exchange features, the applicable conversion or exchange period and the manner of settlement for any conversion or exchange;
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if
other than the full principal amount thereof, the portion of the principal amount of debt securities of the series which shall
be payable upon declaration of acceleration of the maturity thereof;
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additions
to or changes in the covenants applicable to the particular debt securities being issued, including, among others, the consolidation,
merger or sale covenant;
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additions
to or changes in the events of default with respect to the securities and any change in the right of the trustee or the holders
to declare the principal, premium, if any, and interest, if any, with respect to such securities to be due and payable;
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additions
to or changes in or deletions of the provisions relating to covenant defeasance and legal defeasance;
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additions
to or changes in the provisions relating to satisfaction and discharge of the indenture;
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additions
to or changes in the provisions relating to the modification of the indenture both with and without the consent of holders
of debt securities issued under the indenture;
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the
currency of payment of debt securities if other than U.S. dollars and the manner of determining the equivalent amount in U.S.
dollars;
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whether
interest will be payable in cash or additional debt securities at our or the holders’ option and the terms and conditions
upon which the election may be made;
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the
terms and conditions, if any, upon which we will pay amounts in addition to the stated interest, premium, if any and principal
amounts of the debt securities of the series to any holder that is not a “United States person” for federal tax
purposes;
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any
restrictions on transfer, sale or assignment of the debt securities of the series; and
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any
other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities, any other additions
or changes in the provisions of the indenture, and any terms that may be required by us or advisable under applicable laws
or regulations.
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Conversion
or Exchange Rights
We
will set forth in the applicable prospectus supplement the terms on which a series of debt securities may be convertible into
or exchangeable for our common stock or our other securities. We will include provisions as to settlement upon conversion or exchange
and whether conversion or exchange is mandatory, at the option of the holder or at our option. We may include provisions pursuant
to which the number of shares of our common stock or our other securities that the holders of the series of debt securities receive
would be subject to adjustment.
Consolidation,
Merger or Sale
Unless
we provide otherwise in the prospectus supplement applicable to a particular series of debt securities, the indenture will not
contain any covenant that restricts our ability to merge or consolidate, or sell, convey, transfer or otherwise dispose of our
assets as an entirety or substantially as an entirety. However, any successor to or acquirer of such assets (other than any subsidiary
of ours) must assume all of our obligations under the indenture or the debt securities, as appropriate.
Events
of Default under the Indenture
Unless
we provide otherwise in the prospectus supplement applicable to a particular series of debt securities, the following are events
of default under the indenture with respect to any series of debt securities that we may issue:
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if
we fail to pay any installment of interest on any series of debt securities, as and when the same shall become due and payable,
and such default continues for a period of 90 days; provided, however, that a valid extension of an interest payment period
by us in accordance with the terms of any indenture supplemental thereto shall not constitute a default in the payment of
interest for this purpose;
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if
we fail to pay the principal of, or premium, if any, on any series of debt securities as and when the same shall become due
and payable whether at maturity, upon redemption, by declaration or otherwise, or in any payment required by any sinking or
analogous fund established with respect to such series; provided, however, that a valid extension of the maturity of such
debt securities in accordance with the terms of any indenture supplemental thereto shall not constitute a default in the payment
of principal or premium, if any;
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if
we fail to observe or perform any other covenant or agreement contained in the debt securities or the indenture, other than
a covenant specifically relating to another series of debt securities, and our failure continues for 90 days after we
receive written notice of such failure, requiring the same to be remedied and stating that such is a notice of default thereunder,
from the trustee or holders of at least 25% in aggregate principal amount of the outstanding debt securities of the applicable
series; and
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if
specified events of bankruptcy, insolvency or reorganization occur.
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If
an event of default with respect to debt securities of any series occurs and is continuing, other than an event of default specified
in the last bullet point above, the trustee or the holders of at least 25% in aggregate principal amount of the outstanding debt
securities of that series, by notice to us in writing, and to the trustee if notice is given by such holders, may declare the
unpaid principal of, premium, if any, and accrued interest, if any, due and payable immediately. If an event of default specified
in the last bullet point above occurs with respect to us, the principal amount of and accrued interest, if any, of each issue
of debt securities then outstanding shall be due and payable without any notice or other action on the part of the trustee or
any holder.
The
holders of a majority in principal amount of the outstanding debt securities of an affected series may waive any default or event
of default with respect to the series and its consequences, except defaults or events of default regarding payment of principal,
premium, if any, or interest, unless we have cured the default or event of default in accordance with the indenture. Any waiver
shall cure the default or event of default.
Subject
to the terms of the indenture, if an event of default under an indenture shall occur and be continuing, the trustee will be under
no obligation to exercise any of its rights or powers under such indenture at the request or direction of any of the holders of
the applicable series of debt securities, unless such holders have offered the trustee reasonable indemnity. The holders of a
majority in principal amount of the outstanding debt securities of any series will have the right to direct the time, method and
place of conducting any proceeding for any remedy available to the trustee, or exercising any trust or power conferred on the
trustee, with respect to the debt securities of that series, provided that:
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the
direction so given by the holder is not in conflict with any law or the applicable indenture; and
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subject
to its duties under the Trust Indenture Act, the trustee need not take any action that might involve it in personal liability
or might be unduly prejudicial to the holders not involved in the proceeding.
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A
holder of the debt securities of any series will have the right to institute a proceeding under the indenture or to appoint a
receiver or trustee, or to seek other remedies only if:
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the
holder has given written notice to the trustee of a continuing event of default with respect to that series;
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the
holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series have made written
request,
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such
holders have offered to the trustee indemnity satisfactory to it against the costs, expenses and liabilities to be incurred
by the trustee in compliance with the request; and
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the
trustee does not institute the proceeding, and does not receive from the holders of a majority in aggregate principal amount
of the outstanding debt securities of that series other conflicting directions within 90 days after the notice, request
and offer.
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These
limitations do not apply to a suit instituted by a holder of debt securities if we default in the payment of the principal, premium,
if any, or interest on, the debt securities.
We
will periodically file statements with the trustee regarding our compliance with specified covenants in the indenture.
Modification
of Indenture; Waiver
We
and the trustee may change an indenture without the consent of any holders with respect to specific matters:
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to
cure any ambiguity, defect or inconsistency in the indenture or in the debt securities of any series;
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to
comply with the provisions described above under “Description of Debt Securities—Consolidation, Merger or Sale;”
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to
provide for uncertificated debt securities in addition to or in place of certificated debt securities;
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to
add to our covenants, restrictions, conditions or provisions such new covenants, restrictions, conditions or provisions for
the benefit of the holders of all or any series of debt securities, to make the occurrence, or the occurrence and the continuance,
of a default in any such additional covenants, restrictions, conditions or provisions an event of default or to surrender
any right or power conferred upon us in the indenture;
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to
add to, delete from or revise the conditions, limitations, and restrictions on the authorized amount, terms, or purposes of
issue, authentication and delivery of debt securities, as set forth in the indenture;
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to
make any change that does not adversely affect the interests of any holder of debt securities of any series in any material
respect;
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to
provide for the issuance of and establish the form and terms and conditions of the debt securities of any series as provided
above under “Description of Debt Securities—General” to establish the form of any certifications required
to be furnished pursuant to the terms of the indenture or any series of debt securities, or to add to the rights of the holders
of any series of debt securities;
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to
evidence and provide for the acceptance of appointment under any indenture by a successor trustee; or
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to
comply with any requirements of the SEC in connection with the qualification of any indenture under the Trust Indenture Act.
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In
addition, under the indenture, the rights of holders of a series of debt securities may be changed by us and the trustee with
the written consent of the holders of at least a majority in aggregate principal amount of the outstanding debt securities of
each series that is affected. However, unless we provide otherwise in the prospectus supplement applicable to a particular series
of debt securities, we and the trustee may make the following changes only with the consent of each holder of any outstanding
debt securities affected:
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extending
the fixed maturity of any debt securities of any series;
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reducing
the principal amount, reducing the rate of or extending the time of payment of interest, or reducing any premium payable upon
the redemption of any series of any debt securities; or
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reducing
the percentage of debt securities, the holders of which are required to consent to any amendment, supplement, modification
or waiver.
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Discharge
Each
indenture provides that we can elect to be discharged from our obligations with respect to one or more series of debt securities,
except for specified obligations, including obligations to:
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register
the transfer or exchange of debt securities of the series;
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replace
stolen, lost or mutilated debt securities of the series;
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pay
principal of and premium and interest on any debt securities of the series;
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maintain
paying agencies;
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hold
monies for payment in trust;
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recover
excess money held by the trustee;
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compensate
and indemnify the trustee; and
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appoint
any successor trustee.
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In
order to exercise our rights to be discharged, we must deposit with the trustee money or government obligations sufficient to
pay all the principal of, any premium, if any, and interest on, the debt securities of the series on the dates payments are due.
Form,
Exchange and Transfer
We
will issue the debt securities of each series only in fully registered form without coupons and, unless we provide otherwise in
the applicable prospectus supplement, in denominations of $1,000 and any integral multiple thereof. The indenture provides that
we may issue debt securities of a series in temporary or permanent global form and as book-entry securities that will be deposited
with, or on behalf of, The Depository Trust Company, or DTC, or another depositary named by us and identified in the applicable
prospectus supplement with respect to that series. To the extent the debt securities of a series are issued in global form and
as book-entry, a description of terms relating to any book-entry securities will be set forth in the applicable prospectus supplement.
At
the option of the holder, subject to the terms of the indenture and the limitations applicable to global securities described
in the applicable prospectus supplement, the holder of the debt securities of any series can exchange the debt securities for
other debt securities of the same series, in any authorized denomination and of like tenor and aggregate principal amount.
Subject
to the terms of the indenture and the limitations applicable to global securities set forth in the applicable prospectus supplement,
holders of the debt securities may present the debt securities for exchange or for registration of transfer, duly endorsed or
with the form of transfer endorsed thereon duly executed if so required by us or the security registrar, at the office of the
security registrar or at the office of any transfer agent designated by us for this purpose. Unless otherwise provided in the
debt securities that the holder presents for transfer or exchange, we will impose no service charge for any registration of transfer
or exchange, but we may require payment of any taxes or other governmental charges.
We
will name in the applicable prospectus supplement the security registrar, and any transfer agent in addition to the security registrar,
that we initially designate for any debt securities. We may at any time designate additional transfer agents or rescind the designation
of any transfer agent or approve a change in the office through which any transfer agent acts, except that we will be required
to maintain a transfer agent in each place of payment for the debt securities of each series.
If
we elect to redeem the debt securities of any series, we will not be required to:
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issue,
register the transfer of, or exchange any debt securities of that series during a period beginning at the opening of business
15 days before the day of mailing of a notice of redemption of any debt securities that may be selected for redemption
and ending at the close of business on the day of the mailing; or
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register
the transfer of or exchange any debt securities so selected for redemption, in whole or in part, except the unredeemed portion
of any debt securities we are redeeming in part.
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Information
Concerning the Trustee
The
trustee, other than during the occurrence and continuance of an event of default under an indenture, undertakes to perform only
those duties as are specifically set forth in the applicable indenture. Upon an event of default under an indenture, the trustee
must use the same degree of care as a prudent person would exercise or use in the conduct of his or her own affairs. Subject to
this provision, the trustee is under no obligation to exercise any of the powers given it by the indenture at the request of any
holder of debt securities unless it is offered reasonable security and indemnity against the costs, expenses and liabilities that
it might incur.
Payment
and Paying Agents
Unless
we otherwise indicate in the applicable prospectus supplement, we will make payment of the interest on any debt securities on
any interest payment date to the person in whose name the debt securities, or one or more predecessor securities, are registered
at the close of business on the regular record date for the interest.
We
will pay principal of and any premium and interest on the debt securities of a particular series at the office of the paying agents
designated by us, except that unless we otherwise indicate in the applicable prospectus supplement, we will make interest payments
by check that we will mail to the holder or by wire transfer to certain holders. Unless we otherwise indicate in the applicable
prospectus supplement, we will designate the corporate trust office of the trustee as our sole paying agent for payments with
respect to debt securities of each series. We will name in the applicable prospectus supplement any other paying agents that we
initially designate for the debt securities of a particular series. We will maintain a paying agent in each place of payment for
the debt securities of a particular series.
All
money we pay to a paying agent or the trustee for the payment of the principal of or any premium or interest on any debt securities
that remains unclaimed at the end of two years after such principal, premium or interest has become due and payable will be repaid
to us, and the holder of the debt security thereafter may look only to us for payment thereof.
Governing
Law
The
indenture and the debt securities will be governed by and construed in accordance with the internal laws of the State of New York,
except to the extent that the Trust Indenture Act of 1939 is applicable.
DESCRIPTION
OF WARRANTS
The
following description, together with the additional information we may include in any applicable prospectus supplements and free
writing prospectuses, summarizes the material terms and provisions of the warrants that we may offer under this prospectus, which
may consist of warrants to purchase common stock, preferred stock or debt securities and may be issued in one or more series.
Warrants may be issued independently or together with common stock, preferred stock or debt securities offered by any prospectus
supplement, and may be attached to or separate from those securities. While the terms we have summarized below will apply generally
to any warrants that we may offer under this prospectus, we will describe the particular terms of any series of warrants that
we may offer in more detail in the applicable prospectus supplement and any applicable free writing prospectus. The terms of any
warrants offered under a prospectus supplement may differ from the terms described below. However, no prospectus supplement will
fundamentally change the terms that are set forth in this prospectus or offer a security that is not registered and described
in this prospectus at the time of its effectiveness.
We
have filed forms of the warrant agreements as exhibits to the registration statement of which this prospectus is a part. We will
file as exhibits to the registration statement of which this prospectus is a part, or will incorporate by reference from reports
that we file with the SEC, the form of warrant agreement, if any, including a form of warrant certificate, that describes the
terms of the particular series of warrants we are offering. The following summaries of material provisions of the warrants and
the warrant agreements are subject to, and qualified in their entirety by reference to, all the provisions of the warrant agreement
and warrant certificate applicable to the particular series of warrants that we may offer under this prospectus. We urge you to
read the applicable prospectus supplements related to the particular series of warrants that we may offer under this prospectus,
as well as any related free writing prospectuses, and the complete warrant agreements and warrant certificates that contain the
terms of the warrants.
General
In
the applicable prospectus supplement, we will describe the terms of the series of warrants being offered, including, to the extent
applicable:
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the
title of such securities;
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the
offering price or prices and aggregate number of warrants offered;
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the
currency or currencies for which the warrants may be purchased;
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the
designation and terms of the securities with which the warrants are issued and the number of warrants issued with each such
security or each principal amount of such security;
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the
date on and after which the warrants and the related securities will be separately transferable;
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the
minimum or maximum amount of such warrants which may be exercised at any one time
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in
the case of warrants to purchase debt securities, the principal amount of debt securities purchasable upon exercise of one
warrant and the price at which, and currency in which, this principal amount of debt securities may be purchased upon such
exercise;
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in
the case of warrants to purchase common stock or preferred stock, the number of shares of common stock or preferred stock,
as the case may be, purchasable upon the exercise of one warrant and the price at which, and the currency in which, these
shares may be purchased upon such exercise;
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the
effect of any merger, consolidation, sale or other disposition of our business on the warrant agreements and the warrants;
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the
terms of any rights to redeem or call the warrants;
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the
terms of any rights to force the exercise of the warrants;
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any
provisions for changes to or adjustments in the exercise price or number of securities issuable upon exercise of the warrants;
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the
dates on which the right to exercise the warrants will commence and expire;
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the
manner in which the warrant agreements and warrants may be modified;
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a
discussion of any material or special U.S. federal income tax considerations of holding or exercising the warrants;
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the
terms of the securities issuable upon exercise of the warrants; and
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any
other specific terms, preferences, rights or limitations of or restrictions on the warrants.
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Before
exercising their warrants, holders of warrants will not have any of the rights of holders of the securities purchasable upon such
exercise, including:
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in
the case of warrants to purchase common stock or preferred stock, the right to receive dividends, if any, or payments upon
our liquidation, dissolution or winding up or to exercise voting rights, if any; or
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in
the case of warrants to purchase debt securities, the right to receive payments of principal of, or premium, if any, or interest
on, the debt securities purchasable upon exercise or to enforce covenants in the applicable indenture.
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Exercise
of Warrants
Each
warrant will entitle the holder to purchase the securities that we specify in the applicable prospectus supplement at the exercise
price that we describe in the applicable prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement,
holders of the warrants may exercise the warrants at any time up to the specified time on the expiration date that we set forth
in the applicable prospectus supplement. After the close of business on the expiration date, unexercised warrants will become
void.
Unless
we otherwise specify in the applicable prospectus supplement, holders of the warrants may exercise the warrants by delivering
the warrant certificate representing the warrants to be exercised together with specified information, and paying the required
amount to the warrant agent in immediately available funds, as provided in the applicable prospectus supplement. We will set forth
on the reverse side of the warrant certificate and in the applicable prospectus supplement the information that the holder of
the warrant will be required to deliver to the warrant agent in connection with the exercise of the warrant.
On
receipt of payment and the warrant or warrant certificate, as applicable, properly completed and duly executed at the corporate
trust office of the warrant agent, if any, or any other office, including ours, indicated in the prospectus supplement, we will,
as soon as practicable, issue and deliver the securities purchasable on such exercise. If less than all of the warrants (or the
warrants represented by such warrant certificate) are exercised, a new warrant or a new warrant certificate, as applicable, will
be issued for the remaining warrants.
Governing
Law
Unless
we provide otherwise in the applicable prospectus supplement, the warrants and warrant agreements, and any claim, controversy
or dispute arising under or related to the warrants or warrant agreements, will be governed by and construed in accordance with
the laws of the State of New York.
Enforceability
of Rights by Holders of Warrants
Each
warrant agent, if any, will act solely as our agent under the applicable warrant agreement and will not assume any obligation
or relationship of agency or trust with any holder of any warrant. A single bank or trust company may act as warrant agent for
more than one issue of warrants. A warrant agent will have no duty or responsibility in case of any default by us under the applicable
warrant agreement or warrant, including any duty or responsibility to initiate any proceedings at law or otherwise, or to make
any demand upon us. Any holder of a warrant may, without the consent of the related warrant agent or the holder of any other warrant,
enforce by appropriate legal action its right to exercise, and receive the securities purchasable upon exercise of, its warrants.
LEGAL
OWNERSHIP OF SECURITIES
We
can issue securities in registered form or in the form of one or more global securities. We describe global securities in greater
detail below. We refer to those persons who have securities registered in their own names on the books that we or any applicable
trustee or depositary maintain for this purpose as the “holders” of those securities. These persons are the legal
holders of the securities. We refer to those persons who, indirectly through others, own beneficial interests in securities that
are not registered in their own names, as “indirect holders” of those securities. As we discuss below, indirect holders
are not legal holders, and investors in securities issued in book-entry form or in street name will be indirect holders.
Book-Entry
Holders
We
may issue securities in book-entry form only, as we will specify in the applicable prospectus supplement. This means securities
may be represented by one or more global securities registered in the name of a financial institution that holds them as depositary
on behalf of other financial institutions that participate in the depositary’s book-entry system. These participating institutions,
which are referred to as participants, in turn, hold beneficial interests in the securities on behalf of themselves or their customers.
Only
the person in whose name a security is registered is recognized as the holder of that security. Global securities will be registered
in the name of the depositary or its participants. Consequently, for global securities, we will recognize only the depositary
as the holder of the securities, and we will make all payments on the securities to the depositary. The depositary passes along
the payments it receives to its participants, which in turn pass the payments along to their customers who are the beneficial
owners. The depositary and its participants do so under agreements they have made with one another or with their customers; they
are not obligated to do so under the terms of the securities.
As
a result, investors in a global security will not own securities directly. Instead, they will own beneficial interests in a global
security, through a bank, broker or other financial institution that participates in the depositary’s book-entry system
or holds an interest through a participant. As long as the securities are issued in global form, investors will be indirect holders,
and not legal holders, of the securities.
Street
Name Holders
We
may terminate a global security or issue securities that are not issued in global form. In these cases, investors may choose to
hold their securities in their own names or in “street name.” Securities held by an investor in street name would
be registered in the name of a bank, broker or other financial institution that the investor chooses, and the investor would hold
only a beneficial interest in those securities through an account he or she maintains at that institution.
For
securities held in street name, we or any applicable trustee or depositary will recognize only the intermediary banks, brokers
and other financial institutions in whose names the securities are registered as the holders of those securities, and we or any
such trustee or depositary will make all payments on those securities to them. These institutions pass along the payments they
receive to their customers who are the beneficial owners, but only because they agree to do so in their customer agreements or
because they are legally required to do so. Investors who hold securities in street name will be indirect holders, not holders,
of those securities.
Legal
Holders
Our
obligations, as well as the obligations of any applicable trustee or third party employed by us or a trustee, run only to the
legal holders of the securities. We do not have obligations to investors who hold beneficial interests in global securities, in
street name or by any other indirect means. This will be the case whether an investor chooses to be an indirect holder of a security
or has no choice because we are issuing the securities only in global form.
For
example, once we make a payment or give a notice to the legal holder, we have no further responsibility for the payment or notice
even if that legal holder is required, under agreements with its participants or customers or by law, to pass it along to the
indirect holders but does not do so. Similarly, we may want to obtain the approval of the holders to amend an indenture, to relieve
us of the consequences of a default or of our obligation to comply with a particular provision of an indenture, or for other purposes.
In such an event, we would seek approval only from the legal holder, and not the indirect holders, of the securities. Whether
and how the legal holders contact the indirect holders is up to the legal holders.
Special
Considerations for Indirect Holders
If
you hold securities through a bank, broker or other financial institution, either in book-entry form because the securities are
represented by one or more global securities or in street name, you should check with your own institution to find out:
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how
it handles securities payments and notices;
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whether
it imposes fees or charges;
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how
it would handle a request for the holders’ consent, if ever required;
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whether
and how you can instruct it to send you securities registered in your own name so you can be a holder, if that is permitted
in the future;
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how
it would exercise rights under the securities if there were a default or other event triggering the need for holders to act
to protect their interests; and
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if
the securities are in book-entry form, how the depositary’s rules and procedures will affect these matters.
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Global
Securities
A
global security is a security that represents one or any other number of individual securities held by a depositary. Generally,
all securities represented by the same global securities will have the same terms.
Each
security issued in book-entry form will be represented by a global security that we issue to, deposit with and register in the
name of a financial institution or its nominee that we select. The financial institution that we select for this purpose is called
the depositary. Unless we specify otherwise in the applicable prospectus supplement, DTC, New York, New York, will be the depositary
for all securities issued in book-entry form.
A
global security may not be transferred to or registered in the name of anyone other than the depositary, its nominee or a successor
depositary, unless special termination situations arise. We describe those situations below under “—Special Situations
When a Global Security Will Be Terminated.” As a result of these arrangements, the depositary, or its nominee, will be the
sole registered owner and legal holder of all securities represented by a global security, and investors will be permitted to
own only beneficial interests in a global security. Beneficial interests must be held by means of an account with a broker, bank
or other financial institution that in turn has an account with the depositary or with another institution that does. Thus, an
investor whose security is represented by a global security will not be a legal holder of the security, but only an indirect holder
of a beneficial interest in the global security.
If
the prospectus supplement for a particular security indicates that the security will be issued as a global security, then the
security will be represented by a global security at all times unless and until the global security is terminated. If termination
occurs, we may issue the securities through another book-entry clearing system or decide that the securities may no longer be
held through any book-entry clearing system.
Special
Considerations for Global Securities
As
an indirect holder, an investor’s rights relating to a global security will be governed by the account rules of the investor’s
financial institution and of the depositary, as well as general laws relating to securities transfers. We do not recognize an
indirect holder as a holder of securities and instead deal only with the depositary that holds the global security.
If
securities are issued only as global securities, an investor should be aware of the following:
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an
investor cannot cause the securities to be registered in his or her name, and cannot obtain non-global certificates for his
or her interest in the securities, except in the special situations we describe below;
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an
investor will be an indirect holder and must look to his or her own bank or broker for payments on the securities and protection
of his or her legal rights relating to the securities, as we describe above;
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an
investor may not be able to sell interests in the securities to some insurance companies and to other institutions that are
required by law to own their securities in non-book-entry form;
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an
investor may not be able to pledge his or her interest in the global security in circumstances where certificates representing
the securities must be delivered to the lender or other beneficiary of the pledge in order for the pledge to be effective;
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the
depositary’s policies, which may change from time to time, will govern payments, transfers, exchanges and other matters
relating to an investor’s interest in the global security;
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we
and any applicable trustee have no responsibility for any aspect of the depositary’s actions or for its records of ownership
interests in the global security, nor will we or any applicable trustee supervise the depositary in any way;
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the
depositary may, and we understand that DTC will, require that those who purchase and sell interests in the global security
within its book-entry system use immediately available funds, and your broker or bank may require you to do so as well; and
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financial
institutions that participate in the depositary’s book-entry system, and through which an investor holds its interest
in the global security, may also have their own policies affecting payments, notices and other matters relating to the securities.
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There
may be more than one financial intermediary in the chain of ownership for an investor. We do not monitor and are not responsible
for the actions of any of those intermediaries.
Special
Situations When a Global Security Will Be Terminated
In
a few special situations described below, a global security will terminate and interests in it will be exchanged for physical
certificates representing those interests. After that exchange, the choice of whether to hold securities directly or in street
name will be up to the investor. Investors must consult their own banks or brokers to find out how to have their interests in
securities transferred to their own names, so that they will be direct holders. We have described the rights of holders and street
name investors above.
Unless
we provide otherwise in the applicable prospectus supplement, the global security will terminate when the following special situations
occur:
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if
the depositary notifies us that it is unwilling, unable or no longer qualified to continue as depositary for that global security
and we do not appoint another institution to act as depositary within 90 days;
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if
we notify any applicable trustee that we wish to terminate that global security; or
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if
an event of default has occurred with regard to securities represented by that global security and has not been cured or waived.
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The
applicable prospectus supplement may also list additional situations for terminating a global security that would apply only to
the particular series of securities covered by the prospectus supplement. When a global security terminates, the depositary, and
neither we nor any applicable trustee, is responsible for deciding the names of the institutions that will be the initial direct
holders.
PLAN
OF DISTRIBUTION
We
may sell the securities from time to time pursuant to underwritten public offerings, negotiated transactions, block trades or
a combination of these methods. We may sell the securities to or through underwriters or dealers, through agents or directly to
one or more purchasers. We may distribute securities from time to time in one or more transactions:
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at
a fixed price or prices, which may be changed;
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at
market prices prevailing at the time of sale;
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at
prices related to such prevailing market prices; or
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We
may also sell equity securities covered by this registration statement in an “at the market offering” as defined in
Rule 415 under the Securities Act. Such offering may be made into an existing trading market for such securities in transactions
at other than a fixed price, either:
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on
or through the facilities of Nasdaq or any other securities exchange or quotation or trading service on which such securities
may be listed, quoted or traded at the time of sale; and/or
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to
or through a market maker other than on Nasdaq or such other securities exchanges or quotation or trading services.
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Such
at the market offerings, if any, may be conducted by underwriters acting as principal or agent.
A
prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) will
describe the terms of the offering of the securities, including, to the extent applicable:
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the
name or names of any underwriters, dealers or agents, if any;
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the
purchase price of the securities and the proceeds we will receive from the sale;
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any
over-allotment options under which underwriters may purchase additional securities from us;
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any
agency fees or underwriting discounts and other items constituting agents’ or underwriters’ compensation;
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any
public offering price;
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any
discounts or concessions allowed or reallowed or paid to dealers; and
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any
securities exchange or market on which the securities may be listed.
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Only
underwriters named in the prospectus supplement are underwriters of the securities offered by the prospectus supplement.
If
underwriters are used in the sale, they will acquire the securities for their own account and may resell the securities from time
to time in one or more transactions at a fixed public offering price or at varying prices determined at the time of sale. The
obligations of the underwriters to purchase the securities will be subject to the conditions set forth in the applicable underwriting
agreement. We may offer the securities to the public through underwriting syndicates represented by managing underwriters or by
underwriters without a syndicate. Subject to certain conditions, the underwriters will be obligated to purchase all of the securities
offered by the prospectus supplement. Any public offering price and any discounts or concessions allowed or reallowed or paid
to dealers may change from time to time. We may use underwriters with whom we have a material relationship. We will describe in
the prospectus supplement, naming the underwriter, the nature of any such relationship.
We
may sell securities directly or through agents we designate from time to time. We will name any agent involved in the offering
and sale of securities, and we will describe any commissions we will pay the agent in the prospectus supplement. Unless the prospectus
supplement states otherwise, our agent will act on a best-efforts basis for the period of its appointment.
We
may authorize agents or underwriters to solicit offers by certain types of institutional investors to purchase securities from
us at the public offering price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for payment
and delivery on a specified date in the future. We will describe the conditions to these contracts and the commissions we must
pay for solicitation of these contracts in the prospectus supplement.
We
may provide agents and underwriters with indemnification against civil liabilities related to this offering, including liabilities
under the Securities Act, or contribution with respect to payments that the agents or underwriters may make with respect to these
liabilities. Agents and underwriters may engage in transactions with, or perform services for, us in the ordinary course of business.
All
securities we offer, other than common stock, will be new issues of securities with no established trading market. Any underwriters
may make a market in these securities, but will not be obligated to do so and may discontinue any market making at any time without
notice. We cannot guarantee the liquidity of the trading markets for any securities.
Any
underwriter may engage in overallotment, stabilizing transactions, short covering transactions and penalty bids. Overallotment
involves sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids to purchase
the underlying security so long as the stabilizing bids do not exceed a specified maximum. Short covering transactions involve
purchases of the securities in the open market after the distribution is completed to cover short positions. Penalty bids permit
the underwriters to reclaim a selling concession from a dealer when the securities originally sold by the dealer are purchased
in a stabilizing or covering transaction to cover short positions. Those activities may cause the price of the securities to be
higher than it would otherwise be. If commenced, the underwriters may discontinue any of the activities at any time. These transactions
may be effected on any exchange or over-the-counter market or otherwise.
Any
underwriters who are qualified market makers on Nasdaq may engage in passive market making transactions in the securities on Nasdaq
in accordance with Rule 103 of Regulation M, during the business day prior to the pricing of the offering, before the commencement
of offers or sales of the securities. Passive market makers must comply with applicable volume and price limitations and must
be identified as passive market makers. In general, a passive market maker must display its bid at a price not in excess of the
highest independent bid for such security; if all independent bids are lowered below the passive market maker’s bid, however,
the passive market maker’s bid must then be lowered when certain purchase limits are exceeded. Passive market making may
stabilize the market price of the securities at a level above that which might otherwise prevail in the open market and, if commenced,
may be discontinued at any time.
LEGAL
MATTERS
Unless
otherwise indicated in the applicable prospectus supplement, certain legal matters in connection with the offering and the validity
of the securities offered by this prospectus, and any supplement thereto, will be passed upon by Cooley LLP. Additional legal
matters may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus
supplement.
EXPERTS
The
consolidated financial statements of ArTara Subsidiary, Inc. (formerly ArTara Therapeutics, Inc.) as of December 31, 2019 and
2018 and for each of the years then ended, incorporated by reference in this prospectus from the Company’s Current Report
on Form 8-K/A, filed with the SEC on March 20, 2020, have been audited by Marcum, LLP, an independent registered public accounting
firm, as set forth in their report, which is incorporated herein by reference. Such consolidated financial statements have been
so incorporated by reference in reliance on such report given upon such firm as experts in auditing and accounting.
The consolidated financial statements of Protara Therapeutics, Inc. (formerly Proteon Therapeutics, Inc. and ArTara Therapeutics,
Inc.) at December 31, 2019 and 2018, and for each of the years then ended, incorporated by reference in this prospectus and
registration statement have been audited by Ernst & Young LLP, independent registered public accounting firm, as set forth
in their report thereon appearing elsewhere herein, and are included in reliance upon such report given on the authority of
such firm as experts in accounting and auditing.
WHERE
YOU CAN FIND MORE INFORMATION
This
prospectus is part of the registration statement on Form S-3 we filed with the SEC under the Securities Act. This prospectus does
not contain all of the information set forth in the registration statement and the exhibits to the registration statement. For
further information with respect to us and the securities we are offering under this prospectus, we refer you to the registration
statement and the exhibits and schedules filed as a part of the registration statement. You should rely only on the information
contained in this prospectus or incorporated by reference. We have not authorized anyone else to provide you with different information.
We are not making an offer of these securities in any state where the offer is not permitted. You should not assume that the information
in this prospectus is accurate as of any date other than the date on the front page of this prospectus, regardless of the time
of delivery of this prospectus or any sale of the securities offered by this prospectus.
We
must comply with the informational requirements of the Exchange Act, and we are required to file reports and proxy statements
and other information with the SEC. You may read and copy these reports, proxy statements and other information on the SEC’s
website at http://www.sec.gov, which contains reports, proxy and information statements and other information regarding issuers
like us that file electronically with the SEC. We maintain a website at www.protaratx.com. The information contained in, or that
can be accessed through, our website is not incorporated by reference herein and is not part of this prospectus.
Statements
contained in this prospectus as to the contents of any contract or other document are not necessarily complete, and in each instance
we refer you to the copy of the contract or document filed as an exhibit to the registration statement, each such statement being
qualified in all respects by such reference.
INCORPORATION
OF CERTAIN INFORMATION BY REFERENCE
The
SEC allows us to “incorporate by reference” information that we file with it, which means that we can disclose important
information to you by referring you to those documents. The information incorporated by reference is an important part of this
prospectus. Information in this prospectus supersedes information incorporated by reference that we filed with the SEC prior to
the date of this prospectus, while information that we file later with the SEC will automatically update and supersede the information
in this prospectus. We also incorporate by reference into this prospectus the documents listed below and any future filings made
by us with the SEC (other than current reports or portions thereof furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits
filed on such form that are related to such items and other portions of documents that are furnished, but not filed, pursuant
to applicable rules promulgated by the SEC) that are filed by us with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of
the Exchange Act (i) after the date of the initial filing of the registration statement of which this prospectus is a part and
prior to effectiveness of the registration statement, and (ii) after the effectiveness of the registration statement but prior
to the termination of the offering of the securities covered by the applicable prospectus supplement:
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our
Annual Report on Form 10-K for the fiscal year ended December 31, 2019, filed with the SEC on March 20, 2020;
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the
information specifically incorporated by reference into our Annual Report on Form 10-K for the year ended December 31, 2019
from our definitive proxy statement on Schedule 14A, as filed with the SEC on April 23, 2020;
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our
Quarterly Report on Form 10-Q for the quarter ended March 31, 2020, filed with the SEC on May 13, 2020;
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the
description of our common stock contained in our registration statement on Form 8-A filed with the SEC on October 16,
2014, including any amendments or reports filed for the purposes of updating this description.
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We
will furnish without charge to each person, including any beneficial owner, to whom this prospectus supplement and the accompanying
prospectus is delivered, upon written or oral request, a copy of any document incorporated by reference. Requests should be addressed
to 1 Little West 12th Street, New York, NY 10014, Attn: Secretary or may be made telephonically at (646) 844-0337. Copies of these
filings are filings are also available, without charge, on the SEC’s website at www.sec.gov and on our website www.protaratx.com
as soon as reasonably practicable after they are filed electronically with the SEC. The information contained on our website is
not part of this prospectus supplement or the accompanying prospectus.
In
accordance with Rule 412 of the Securities Act, any statement contained in a document incorporated by reference in this prospectus
supplement or the accompanying prospectus shall be deemed modified, superseded or replaced for the purposes of this prospectus
supplement or the accompanying prospectus to the extent that a statement contained in this prospectus supplement or the accompanying
prospectus or in any other subsequently filed document that also is or is deemed to be incorporated by reference herein modifies
or supersedes such statement.
4,148
Shares
Series
1 Convertible Preferred Stock
PROSPECTUS
SUPPLEMENT
Joint
Book-Running Managers
Cowen
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Guggenheim
Securities
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Lead
Manager
Oppenheimer
& Co.
Co-Manager
H.C.
Wainwright & Co.
September 22, 2020.
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