UPDATE: Novartis Gets Rights To Broad-Spectrum Antibiotic
October 08 2009 - 3:21AM
Dow Jones News
Swiss pharmaceutical company Novartis AG (NVS) said Thursday it
has gained exclusive worldwide rights to market what could become
the first once-a-day broad-spectrum antibiotic that can be given as
a tablet or intravenously to treat infections caused by
drug-resistant bacteria.
The drug candidate, dubbed PTK 0796, is currently in late-stage
trials to treat patients with complicated skin and skin structure
infections and Novartis will share the responsibility for
developing the drug with U.S.-based privately held Paratek
Pharmaceuticals.
"Its broad spectrum of activity means it could be used as a
single agent against a range of bacteria, unlike other antibiotics
which may have to be used in combination," the company said.
Gaining the rights makes a lot of strategic sense, said
pharmaceuticals analyst Michael Nawrath of Zuercher Kantonalbank,
who expects the share price to react positively. "The advantage
over other such antibiotics already on the market is that it can be
given in one dose, while for example Pfizer Inc.'s (PFE) Zyvox
needs to be given in two doses a day," he said.
Based on an estimated 150,000 deaths a year from
hospital-acquired infections across the U.S. and Europe, Nawrath
sees peak sales potential of more than $1 billion.
Novartis highlighted that because PTK 0796 can be given as a
30-minute intravenous infusion or as a tablet and patients won't
have to remain in hospital to receive the treatment. This would not
only save healthcare costs, but also lower the risk of further
infections.
Broad-spectrum antibiotics fight bacteria such as
methicillin-resistant Staphylococcus aureus, or MRSA, which cause
complicated, sometimes fatal skin infections and which are
resistant to drugs already on the market.
Year-to-date, Novartis shares have lost 2.9%, underperforming a
4.6% rise in the European Health Care sector Stoxx 600. They closed
at 51.20 Swiss francs ($49.80) Wednesday.
The in-licensing of PTK 0796 represents a further expansion of
the Basel-based company's infectious diseases portfolio following
the acquisition of Protez Pharmaceuticals in 2008.
-By Julia Mengewein, Dow Jones Newswires; +41 43 443 80 45;
julia.mengewein@dowjones.com