By Denny Jacob

International stocks trading in New York closed mostly lower on Wednesday.

The S&P/BNY Mellon index of American depositary receipts ticked down 1.2% to 140.51. The European index edged down 1% to 136.68. The Asian index lost 1.8% to 160.90. The Latin American index moved up 0.7% to 182.59, while the emerging-markets index slipped 1.6% to 269.98.

AstraZeneca PLC was among those whose ADRs traded actively.

The pharmaceutical company edged down 0.5% after it said calquence was approved in Japan for adult patients with treatment-naïve chronic lymphocytic leukaemia, while imfinzi and imjudo were approved in Japan as a treatment for advanced liver cancer, biliary tract cancer and lung cancer.

ABB Ltd. retreated 1.2% after the Swiss technology company said it completed its divestment of Hitachi Energy, a joint venture between Hitachi Ltd. and ABB's Power Grids business, to Hitachi. ABB said it realized a net positive cash inflow of about $1.43 billion in the fourth quarter through the divestment.

Write to Denny Jacob at denny.jacob@wsj.com

(END) Dow Jones Newswires

December 28, 2022 16:52 ET (21:52 GMT)

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