Annovis Bio Inc (ANVS) News

Hyper quick consolidation Annovis
Hidden gem ICCM IceCure.Once
$2.00 Breaks $10.00+ in play disruptive minimal invasive cancer technology that freezes and kills tumors local anesthetic done in less than an hour no surgery needed or radiation treatment aiming to treat a wide array of cancers from early to late stage malignant cancers. Follow up data for 5 years on early stage breast cancer data sets being complied for later stage cancers incredible data for late stage breast cancer patients with tumors twice as large compared to the early stage breast cancer patients in diameter 92% non recurrence and 97% non recurrence for early stage breast cancer. 100% patient and physician satisfaction!! Insurance companies are embracing the IceCure Technology win win for all parties involved.
$ANVS

So checking out Seeking Alpha today....

[Three things to note here:

The "dose-dependent and statistically significant improvements in cognition in the overall enrolled PD population" (n=523) is an inverse one, i.e., 10mg improved more than 20mg.
This inverse "dose-dependent" improvement in cognition occurs in the overall enrolled patients (n=523), but is reversed in the "Mild Dementia MMSE 20-26" subgroup, where the 10mg group has no statistically significant improvement.
MMSE improvement data is the only data reported from the entire enrolled patients (n=523) in the PR./quote]

https://seekingalpha.com/article/4702593-annovis-bio-a-close-look-at-their-parkinsons-trial-data

I've been following Anavex for years, and I believe their approach is better,




Anavex Life Sciences Reports New Mechanism of Action Data Related to ANAVEX Compounds Targeting Sigma-1 Receptor
?

?

Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer, announced today the presentation of new mechanism of action data related to ANAVEX compounds targeting the sigma-1 receptor at the AD/PDTM 2017 Meeting.



Hall H et al presented preclinical data indicating that during pathological conditions, ANAVEX 3-71 demonstrated the formation of new synapses between neurons (synaptogenesis) without causing an abnormal increase in the number of astrocytes. In neurodegenerative diseases like Alzheimer’s and Parkinson’s disease, synaptogenesis is believed to be impaired.



Goguadze N et al presented preclinical data indicating that in addition to reducing oxidative stress, ANAVEX 2-73, ANAVEX 3-71 and ANAVEX 1-41 also demonstrated protective effects of the mitochondrial enzyme complexes I and IV during pathological conditions. The mitochondrial enzyme complex IV is directly involved in the synthesis of ATP, which provides energy within cells for metabolism. It is believed that energy production impairment and mitochondrial dysfunction play a role in the pathogenesis of neurodegenerative disorders and neurodevelopmental diseases.



“These new results provide converging evidence on mechanism of action as well as possible disease-modifying properties potentially by restoring homeostasis by means of the sigma-1 receptor agonists in our pipeline. This data also provides a foundation for our ongoing translational research efforts,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex.



Both data sets described that Aß1-42 (amyloid beta) significantly impairs biological function in the respective animal models and the observed regain of function confirmed the protective potential of ANAVEX sigma-1 receptor agonists against amyloid beta -induced toxicity. The former presentation further reported that although that the transgenic McGill rats had a very late stage of Alzheimer’s disease-like pathology (13 months of age), treatment with ANAVEX 3-71 fully reversed cognitive deficits, reduced amyloid pathology and also significantly reduced inflammation. Furthermore, the sustained recovery in cognition and pathophysiology observed following a month-long washout phase in advanced pathology (19 months of age) strongly suggests true disease-modifying properties of ANAVEX 3-71.




AI agrees with me -

query:
does clearing amyloid plaque stop alzheimer's disease

Search Labs | AI Overview
Learn more
…
No, clearing amyloid plaque alone is not likely to stop Alzheimer's disease. While amyloid plaque buildup is a hallmark of Alzheimer's disease, researchers believe that other factors also contribute to its progression, such as tau protein tangles, immune function, and vascular health. In fact, some research suggests that 25% of people with a clinical diagnosis of Alzheimer's disease have little to no amyloid in their brains.

Thank you

Game changing indications for their respected diseases Annovis for PD and AD
and ICCM for cancer killing a wide array of cancers with IceCure cryoblast freeing technology no surgery or radiation needed 5 year follow up studies approved in 15 countries.
$ANVS

The chart shows 5 minutes, apparently some trades were voided...





07/09/24 09:42:17 14.6342 14.55 14.85 505
07/09/24 09:42:16 14.60 14.55 14.90 1,406
07/09/24 09:42:15 14.7217 14.55 14.90 50
07/09/24 09:42:13 14.7217 14.55 14.90 25
07/09/24 09:42:13 14.7217 14.55 14.90 169
07/09/24 09:42:11 14.68 14.50 14.90 1,111
07/09/24 09:42:09 14.835 14.77 14.90 200
07/09/24 09:42:08 14.8947 14.77 14.90 25
07/09/24 09:42:08 14.8947 14.77 14.90 1,111
07/09/24 09:42:06 14.78 14.77 14.78 101
07/09/24 09:42:05 14.78 14.77 14.90 2,848
07/09/24 09:42:03 14.79 14.77 14.90 1,941
07/09/24 09:42:02 14.7788 14.77 14.78 213
07/09/24 09:42:01 14.77 14.77 14.78 105
07/09/24 09:42:00 14.77 14.77 14.78 1,123
07/09/24 09:41:59 14.77 14.77 14.78 2,425
07/09/24 09:41:58 14.835 14.77 14.90 538
07/09/24 09:41:57 14.77 14.77 14.90 4,220
07/09/24 09:41:55 14.999 14.93 15.00 25
07/09/24 09:41:53 14.999 14.93 15.00 400
07/09/24 09:41:52 14.9999 14.93 15.00 50
07/09/24 09:41:52 14.9999 14.93 15.00 4,504
07/09/24 09:41:51 14.965 14.93 15.00 1,359
07/09/24 09:41:50 14.97 14.93 15.00 1,411
07/09/24 09:41:48 14.9427 14.93 15.00 2,766
07/09/24 09:41:47 14.99 14.93 15.00 301
07/09/24 09:41:46 14.98 14.85 15.00 150
07/09/24 09:41:45 15.00 14.85 15.00 3
07/09/24 09:41:45 15.00 14.85 15.00 1,389
07/09/24 09:41:43 14.91 14.85 14.99 20
07/09/24 09:41:40 14.91 14.85 14.97 50
07/09/24 09:41:40 14.91 14.85 14.97 50
07/09/24 09:41:40 14.91 14.85 14.97 1,551
07/09/24 09:41:39 14.97 14.85 14.97 535
07/09/24 09:41:37 14.96 14.77 14.97 600
07/09/24 09:41:36 14.95 14.77 14.97 1,250
07/09/24 09:41:36 14.7701 14.77 14.97 399
07/09/24 09:41:34 14.7801 14.77 14.97 968
07/09/24 09:41:33 14.95 14.77 14.97 1,000
07/09/24 09:41:33 14.94 14.77 14.97 609
07/09/24 09:41:31 14.96 14.77 14.97 205
07/09/24 09:41:30 14.875 14.77 14.97 1,476
07/09/24 09:41:29 14.77 14.77 14.98 202
07/09/24 09:41:28 14.97 14.77 14.98 5,927
07/09/24 09:41:27 14.76 14.51 14.77 1,400
07/09/24 09:41:26 14.70 14.51 14.77 155
07/09/24 09:41:25 14.7037 14.51 14.77 1,309
07/09/24 09:41:24 14.666 14.51 14.77 300
07/09/24 09:41:23 14.71 14.51 14.77 1,049
07/09/24 09:41:22 14.60 14.50 14.77 100
07/09/24 09:41:21 14.62 14.50 14.77 63
07/09/24 09:41:19 14.62 14.47 14.77 1,562
07/09/24 09:41:19 14.60 14.47 14.77 678
07/09/24 09:41:18 14.62 14.47 14.77 200
07/09/24 09:41:17 14.66 14.47 14.77 963
07/09/24 09:41:16 14.65 14.47 14.70 1,637
07/09/24 09:41:14 14.55 14.47 14.65 2
07/09/24 09:41:14 14.55 14.47 14.65 4,772
07/09/24 09:41:13 14.58 14.45 14.65 181
07/09/24 09:41:12 14.513 14.45 14.65 3,101
07/09/24 09:41:11 14.435 14.40 14.41 135
07/09/24 09:41:10 14.435 14.40 14.47 570
07/09/24 09:41:09 14.435 14.40 14.47 4,895
07/09/24 09:41:08 14.435 14.40 14.47 546
07/09/24 09:41:06 14.47 14.40 14.47 371
07/09/24 09:41:06 14.435 14.40 14.47 1,172
07/09/24 09:41:05 14.41 14.40 14.47 137
07/09/24 09:41:04 14.4683 14.40 14.47 485
07/09/24 09:41:02 14.43 14.40 14.47 100
07/09/24 09:41:02 14.28 14.27 14.47 206
07/09/24 09:41:01 14.3337 14.27 14.40 2
07/09/24 09:41:00 14.3337 14.27 14.40 1
07/09/24 09:40:58 14.3337 14.27 14.40 101
07/09/24 09:40:56 14.3999 14.27 14.40 25
07/09/24 09:40:56 14.3999 14.27 14.40 2,622
07/09/24 09:40:55 14.40 14.27 14.40 104
07/09/24 09:40:55 14.2701 14.27 14.40 650
07/09/24 09:40:53 14.30 14.20 14.40 76
07/09/24 09:40:51 14.30 14.20 14.40 37
07/09/24 09:40:50 14.30 14.20 14.40 154
07/09/24 09:40:50 14.30 14.20 14.40 410
07/09/24 09:40:48 14.295 14.20 14.40 21
07/09/24 09:40:48 14.295 14.20 14.40 1,994
07/09/24 09:40:46 14.3278 14.29 14.40 126
07/09/24 09:40:43 14.3278 14.29 14.40 20
07/09/24 09:40:43 14.3278 14.29 14.40 18
07/09/24 09:40:43 14.3278 14.29 14.40 355
07/09/24 09:40:42 14.35 14.29 14.40 39
07/09/24 09:40:40 14.35 14.29 14.40 110
07/09/24 09:40:40 14.2001 14.29 14.40 1,200
07/09/24 09:40:39 14.25 14.20 14.30 45
07/09/24 09:40:37 14.25 14.20 14.30 620
07/09/24 09:40:37 14.31 14.20 14.30 3,651
07/09/24 09:40:35 14.385 14.30 14.47 412
07/09/24 09:40:34 14.40 14.28 14.47 129
07/09/24 09:40:32 14.45 14.28 14.47 16
07/09/24 09:40:32 14.45 14.28 14.47 50
07/09/24 09:40:31 14.45 14.28 14.47 31
07/09/24 09:40:30 14.45 14.28 14.47 354
07/09/24 09:40:29 14.30 14.21 14.47 3,700
07/09/24 09:40:27 14.289 14.20 14.29 1,200
07/09/24 09:40:26 14.24 14.20 14.29 243
07/09/24 09:40:25 14.20 14.19 14.29 90
07/09/24 09:40:24 14.20 14.19 14.29 816
07/09/24 09:40:22 14.15 14.10 14.20 401
07/09/24 09:40:22 14.199 14.10 14.20 2,491
07/09/24 09:40:21 14.12 14.10 14.20 25
07/09/24 09:40:20 14.12 14.02 14.20 1,134
07/09/24 09:40:19 14.1999 14.02 14.20 4,300
07/09/24 09:40:17 14.11 14.02 14.20 674
07/09/24 09:40:17 14.13 14.09 14.20 151
07/09/24 09:40:16 14.145 14.09 14.20 106
07/09/24 09:40:14 14.17 14.09 14.20 10
07/09/24 09:40:14 14.17 14.09 14.20 700
07/09/24 09:40:13 14.09 14.09 14.20 610
07/09/24 09:40:10 14.155 14.02 14.20 1
07/09/24 09:40:10 14.155 14.02 14.20 1,070
07/09/24 09:40:08 14.15 14.02 14.29 191
07/09/24 09:40:08 14.1352 14.02 14.29 2,718
07/09/24 09:40:07 14.19 14.10 14.29 2,194
07/09/24 09:40:05 14.155 14.02 14.29 725
07/09/24 09:40:01 14.155 14.02 14.29 20
07/09/24 09:40:01 14.155 14.02 14.29 3
07/09/24 09:40:01 14.155 14.02 14.29 71
07/09/24 09:40:01 14.155 14.02 14.29 586
07/09/24 09:40:01 14.02 14.02 14.29 935
07/09/24 09:40:00 14.281 14.19 14.29 951
07/09/24 09:39:59 14.29 14.19 14.29 1,538
07/09/24 09:39:57 14.17 14.19 14.29 616
07/09/24 09:39:56 14.105 14.02 14.19 100
07/09/24 09:39:56 14.0217 14.02 14.19 1,052
07/09/24 09:39:55 14.105 14.02 14.19 991
07/09/24 09:39:53 14.105 14.02 14.19 301
07/09/24 09:39:53 14.07 14.02 14.19 1,473
07/09/24 09:39:51 14.145 14.10 14.19 216
07/09/24 09:39:51 14.15 14.10 14.19 6,350
07/09/24 09:39:50 13.89 13.87 13.90 1,109
07/09/24 09:39:48 13.87 13.85 13.89 1,521
07/09/24 09:39:47 13.82 13.75 13.89 3,495
07/09/24 09:39:47 13.76 13.75 13.85 1,550
07/09/24 09:39:46 13.77 13.75 13.79 200
07/09/24 09:39:45 13.77 13.75 13.79 2,932
07/09/24 09:39:43 13.76 13.75 13.85 702
07/09/24 09:39:42 13.80 13.75 13.89 2,159
07/09/24 09:39:40 13.89 13.75 13.90 407
07/09/24 09:39:39 13.90 13.75 13.90 2,737
07/09/24 09:39:38 13.84 13.75 13.90 2,400
07/09/24 09:39:37 13.7901 13.75 13.80 329
07/09/24 09:39:36 13.81 13.75 13.90 40
07/09/24 09:39:35 13.81 13.75 13.90 332
07/09/24 09:39:35 13.80 13.75 13.90 3,335
07/09/24 09:39:33 13.7701 13.77 13.90 3,487
07/09/24 09:39:32 13.7501 13.75 13.76 266
07/09/24 09:39:30 13.7501 13.75 13.76 10
07/09/24 09:39:30 13.7501 13.75 13.76 446
07/09/24 09:39:29 13.76 13.75 13.90 1,312
07/09/24 09:39:28 13.7935 13.75 13.90 16,889


07/09/24 09:34:10 13.95 13.52 14.85 125
07/09/24 09:34:08 13.95 13.94 13.95 102
07/09/24 09:34:07 13.95 13.94 13.95 10
07/09/24 09:34:06 13.95 13.94 13.95 52
07/09/24 09:34:05 13.95 13.94 13.95 101
07/09/24 09:34:03 13.95 13.94 13.95 501
07/09/24 09:34:03 13.95 13.94 13.95 25
07/09/24 09:34:02 13.95 13.92 13.95 191
07/09/24 09:34:01 13.95 13.92 13.95 137
07/09/24 09:34:00 13.95 13.92 13.95 100
07/09/24 09:33:59 13.95 13.92 13.95 200
07/09/24 09:33:58 13.95 13.92 13.95 1,730
07/09/24 09:33:56 13.95 13.92 13.95 218
07/09/24 09:33:55 13.96 13.92 13.95 25
07/09/24 09:33:54 13.96 13.92 14.28 61
07/09/24 09:33:54 13.96 13.92 14.28 2,784
07/09/24 09:33:51 13.96 13.92 14.29 160
07/09/24 09:33:51 13.96 13.92 14.29 2,427
07/09/24 09:33:51 13.95 13.92 14.00 4,716
07/09/24 09:33:49 13.95 13.92 13.95 3,217
07/09/24 09:33:48 13.95 13.92 13.95 16,076
07/09/24 09:33:47 14.50 14.49 14.81 200
07/09/24 09:33:46 14.4901 14.49 14.81 4,481
07/09/24 09:33:45 14.64 14.49 14.80 5,105
07/09/24 09:33:44 14.66 14.52 14.81 25,949
07/09/24 09:33:42 15.15 15.09 15.24 600
07/09/24 09:33:41 15.09 15.15 15.24 109
07/09/24 09:33:41 15.09 15.09 15.24 115

Did you see what they tried to do this morning?
Got to $16.00 -- massive dump down to $13.94 -- trading halt -- now trading at $17.00
No shares available to short -- not even 100 shares.

This is looking more and more like a squeeze in the future.

Good to know!!
ANVS

Disruptive medicine $ANVS could see a Billion plus valuation also ICCM will see massive growth platform that kills a wide array with cancers with cryoblast technology no surgery or radiation needed imagine that. No warrants or debt approved in 15 countries and will be approved in the US soon.insiders own 56% of the shares.

$ANVS

Daily monster runner. Love this one! $$$

Those are shorts with "connections"....

Tried to short 1,000 shares on this. They're saying there's no more shares available to short this. But all I see today are shorts trying to bring this down.

ANVS between 1-2 billion buyout, sometime this year.

LOL -- around 3:00 EST, this hit $16.50 -- and then dropped back to $15.00 in a matter of seconds. Shorting on this stock is restricted...there's no shares available to short. I think we're about to see a squeeze on this.

Always loved this ticker. Money is in the big board stocks. Holding only a couple of OTC's. Icahn and Jones.

It looks good !!
I’m going to buy some.

Tried to short 1,000 shares on this. They're saying there's no more shares available to short this. But all I see today are shorts trying to bring this down.

ANVS will move into triple dollars.

$12.83 Broke through $12.93 and $13.89. Accumulation and will break a second time then $18.01 in sight again

Stocks that will disrupt PD AD $ANVS
Oncology non surgical Freezing indication destroying malignant cancers $ICCM

There’s another pop to 20 soon could be today gl

My vertical call spreads in ANVS are up 754% from a month ago. Will sell my calls tomorrow take initial investment out buy and ride shares until Buyout or FDA approval or what ever the future holds for ANVS very hard market to prove data & move the needle in a significant way in PD and AD. I believe other investors in this area will sell other positions and build a starter in Annovis Bio in the coming days and weeks.

Annovis Pipeline
https://www.annovisbio.com/our-science

Annovis Bio Announces New Data from Phase III Parkinson’s Study Highlighting Improvements in Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Cognition after Treatment with Buntanetap
https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=87ac07b2-1a3d-49b7-af9e-ab0ecdfd5310


$ANVS

ANVS Sold 2/3 in AH @ 11.08 for a +7.6% win
Let's see what Monday brings.

Just missed an 11.38 exit in regular session by 3 cents.

ANVS Late but just in at 10.30

I agree. I'm waiting to see what happens before I jump back in.

$$$ANVS$$$ What a MONSTER!!! $$$

Seems like the shorts are getting nervous with todays sudden ASSSSSSSK Slapping!

ANVS under $10

Trump gonna change it ALL

Someone is selling...which entices short selling. But someone is also buying. And the buying has led me to hold and see where this goes.

Last week
Seeking Alpha allowed me to read
a post regarding what a
Great Short Annovis is..
What sickness lies at the hearts of men?
Why would you short a company trying to save suffering human beings?

We need a new path for non revenue bio pharmaceutical companies and it doesn’t run through our current Fed bureaucracies

Now
Make the 20 mg available now

They allow experimental Covid Jabs that cause myocarditis to unknowledgeavle healthy children! Let knowledgeable death sentenced adults make a choice about this!

God Bless You Maria and your entire team!

ANVS: Indeed!! (And 5% up more, right now, in the Post-M too. At my first review of their news, I thought it was about Alzheimer's affliction, which has a much larger USA patients base vs. Parkinson's!!)

After hours looks strong. I hope tomorrow morning is as strong as well.

ANVS $10.30 Still has room $18.01- $19.85 are the longer term resistance levels. See how it rolls

$$$ANVS$$$ close at $9.21, open at $50.00?

I LOVE MY ANVS!!! $$$

Webinar was AMAZING!!! $$$

$$$ANVS$$$ MONSTER RUN!!! $$$

Seems 50 is easier and 500m cap only.

Looks like this is going back to $5.00

ANVS: Boy, did I totally MISS this one, or what!!! DAMN-IT!!! (Nice Phase-3 results about that nasty Parkinsons disease!!)

Would luv a huge 10,000% move here!!! Let’s F^

Keep it moving up higher.

Either the news that was supposed to be discussed at the shareholder meeting concerning the Parkinson’s Clinical Trials Tests results are great and have been leaked or I don’t know what has happened. Either way, GIDDYUP!!!!!

$$$ANVS$$$ WOWZA!!! $$$

I find this CEO to be a person who faces shareholders full on; very impressive! Hopefully, July 2nd after the close she will address the actual timeline on the upcoming presentation (July 28th to August 1st)....7 minutes only or 45 minutes as mentioned by Maria.

Annovis Bio Files Patent for New Composition of Matter for Buntanetap
MALVERN, Pa.

June 26, 2024 (GLOBE NEWSWIRE) -- via IBN – Annovis Bio Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD), announces the filing of the new composition of matter patent with the U.S. Patent and Trademark Office covering novel solid forms of buntanetap, selecting the best crystal, and building upon the provisional patent filed in June 2023.
This patent covers novel crystalline forms of buntanetap and their use for treating and/or preventing various neurodegenerative conditions. Crystalline forms offer significant advantages over less structured forms, including better solubility and stability. The most stable crystal form of buntanetap (CAS# 3032752-92-1) has been selected as the new lead compound for animal bridge studies and for developing a manufacturing process. The bridge studies were submitted to the FDA and will be discussed in July. The goal is to continue development of our drug and file the NDA with the new crystal form.
“The invention of a new solid form of our drug, buntanetap, and the subsequent patent filing represent groundbreaking milestones for our company. This achievement will allow us not only to continue advancing our pipeline, but also to enhance the drug's properties, ultimately providing greater benefits to our patients,” said Maria Maccecchini, Ph.D., Founder, President, and CEO of Annovis.
A composition of matter patent comes with protection for the new buntanetap crystalline form and all its uses for a 20-year term.  The composition of matter patent is the single most important patent for any pharmaceutical company developing a new drug because it provides adequate runway to develop a drug and bring it to market.

Wondering if the results are good or bad.

What’s the consensus???

Annovis Bio Inc. (NYSE: ANVS) Schedules Investor Webcast to Discuss Parkinson’s Disease Data

MALVERN, Pa., June 25, 2024 (GLOBE NEWSWIRE) -- via IBN – Annovis Bio Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD), today announced that it will host an investor webcast to discuss recent developments and future plans for its lead drug candidate, Buntanetap.

Investor Call Details:
Date and Time: July 2, 2024, 4:30pm ET.
Register Today: Webcast Registration
Topics to Be Covered:

Recent advancements in the development of Buntanetap.

Strategic plans for upcoming clinical trials.
Overview of the company’s progress and future direction.

Register Today: Investors and interested parties are encouraged to register for the webcast in advance. To register, please visit Webcast Registration and complete the registration form.

I am, but watching from the sidelines in case PD are a repeat of AD (as far as market reaction).

Murocman