RNS Number:0424N
Protherics PLC
02 July 2003



                      NOTIFICATION OF DIRECTORS' INTERESTS



Protherics plc ("Protherics") announces that Dr Tony Atkinson and Dr Mike
Peagram, being the directors of Enact Pharma plc ("Enact") who were appointed to
the Board of Protherics with effect from 20 June 2003, were issued with the
consideration due to them under the offer by the Company for Enact (the "Offer")
on 1 July 2003.

As a result, Dr Atkinson holds #682,162 in nominal value of the Protherics
Convertible Loan Notes 2010 issued in connection with the Offer ("Loan Notes")
and 237,256 shares in New Opportunities Investment Trust plc ("NOIT Shares "),
both of which were received in respect of the aggregate number of 4,000,951
ordinary shares of 10p each in Enact ("Enact Shares") acquired from Dr Atkinson
pursuant to the Offer.

Dr Peagram has received #125,402 in nominal value of the Loan Notes and 43,615
NOIT Shares. These were received in consideration for the 735,500 Enact Shares
acquired from him pursuant to the Offer.

In addition, Dr Peagram agreed on 27 June 2003 to acquire #127,875 in nominal
value of Loan Notes and 44,475 NOIT Shares in satisfaction of an outstanding
loan of #75,000 and a further #35,520 in nominal value of Loan Notes and 12,354
NOIT Shares in consideration of #25,000. Disclosure of these acquisitions was
made to the Company on 1 July 2003.

The Loan Notes, in accordance with their terms of issue, are convertible into
ordinary shares of 2p each in the capital of Protherics at a conversion rate of
25p per Protherics share during the period from 19 December 2004 until 19 June
2010. In certain circumstances the Loan Notes will be convertible from 19 June
2004.

For the purposes of this announcement, references to holdings of Dr Atkinson of
Loan Notes, NOIT Shares and Enact Shares includes the holdings of his immediate
family and connected persons (within the meaning of section 346 of the Companies
Act 1985).




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