RNS Number:6934N
Protherics PLC
18 July 2003


                      NOTIFICATION OF DIRECTOR'S INTERESTS

Protherics plc ("Protherics") announces that Dr Mike Peagram, being a director
of Protherics, has agreed on 16 July 2003 to acquire #8,360 in nominal value of
the Protherics Convertible Loan Notes 2010 ("Loan Notes") for a consideration of
#5,000. Disclosure of this acquisition was made to Protherics after the close of
business on 16 July 2003.

As a result, Dr Peagram will hold #297,157 in nominal value of the Loan Notes.

The Loan Notes, in accordance with their terms of issue, are convertible into
ordinary shares of 2p each in the capital of Protherics at a conversion rate of
25p per Protherics share during the period from 19 December 2004 until 19 June
2010. In certain circumstances the Loan Notes will be convertible from 19 June
2004.


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