By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- European stock markets ended lower on Wednesday after unions in Greece called a general strike and as investors worried about a potential reduction in central-bank stimulus.

Also, Germany's constitutional court continued its two-day hearing on the legality of the European Central Bank's bond-buying program, known as Outright Monetary Transactions.

The Stoxx Europe 600 index dropped 0.4% to close at 290.68, the lowest closing level since late April.

The downbeat trading day marked the third straight session of losses, as renewed uncertainty about Greece and concerns about central-bank liquidity spooked investors. Three weeks ago the index had climbed to a multiyear high boosted by aggressive easing from central banks, but comments from U.S. Federal Reserve Chairman Ben Bernanke about potential tapering of quantitative easing sparked a correction.

"Markets are afraid that we will go from a quantitative-easing high to a quantitative-easing cold turkey," said Justin Urquhart Stewart, co-founder of Seven Investment Management.

"It's like any other drug. It takes more to work the more you get and has an effect of dependency. It becomes more difficult to come off," he added. "What we need to turn markets around is an affirmation from Bernanke that QE will be withdrawn at some point, but not now."

Worries over Greece were also back in the spotlight on Wednesday, after equity index provider MSCI Inc. (MXB) lowered the country to emerging-market from developed status. Adding to the country's woes, the two biggest labor unions called a 24-hour general strike starting on Thursday in protest over the government's shutdown of its state broadcaster, the Hellenic Broadcasting Corporation (ERT).

The Athex Composite lost 3.2% to close at 867.08.

On Tuesday, the index dropped 4.7% on reports the country will miss its asset-sale goal by about 1 billion euros ($1.3 billion) this year and will have to ask lenders for a lower target.

Industrial production surprises to the upside

Investors also focused on euro-zone industrial-production data, which showed a 0.4% improvement in April, beating expectations.

The only material growth impulses came "from Germany and France while the rest of the major euro-area economies recorded much more lackluster figures," said James Ashley, senior economist at RBC Capital Markets, in a note.

"In other words, of course it is positive news that the euro-area industrial sector has now managed to eke out three months of growth, but the heavy reliance on a single economy leaves the region vulnerable to any slowdown that might befall Germany. But, for now, we'll take what we can get and localized growth is better than no growth," he added.

In Germany, the constitutional court continued its two-day hearing about the ECB's bond-buying program. Executive board member of the ECB Jörg Asmussen said at the hearing on Tuesday he was "firmly convinced that introducing the OMT program was the right thing to do to ensure price stability in the euro area. After all, a currency can only be stable if its continued existence is not in doubt."

Bundesbank President Jens Weidmann said unlimited bond purchases would infringe the ECB's mandate. The Bundesbank has earlier criticized the OMT program for creating moral hazard and taking pressure off governments. Read: Just say no to ECB bond-buying.

A decision from the court is not expected until after the German election in September.

Movers

Among notable movers on Wednesday, shares of HeidelbergCement AG lost 5.1% in Frankfurt after Morgan Stanley cut the firm to equal weight from overweight.

Volkswagen AG fell 3.3% after the car maker recalled almost 26,000 vehicles in Australia due to faulty gearboxes.

Shares of Kabel Deutschland Holding AG rallied 8.2% after Vodafone Group PLC (VOD) confirmed it has made a preliminary approach about making an offer for the German TV and Internet provider. Shares of Vodafone dropped 2.2%.

Germany's DAX 30 index slid 1% to 8,143.27.

France's CAC 40 index dropped 0.4% to 3,793.70, with banks on the decline. Société Générale SA fell 2.5% and BNP Paribas SA slipped 1.2%.

In the U.K., Barclays PLC (BCS) dropped 2.9% and Lloyds Banking Group PLC (LYG) lost 1.3%.

The U.K.'s FTSE 100 index fell 0.6% to 6,299.45.

Bucking the negative trend, BT Group PLC rose 1.4% to 3.09 pounds ($4.84) a share after Credit Suisse reiterated its outperform rating on the firm and raised the price target to GBP3.50 from GBP3.

Outside the major indexes, shares of Industria de Diseno Textil SA , also known as Inditex and owner of the Zara brand, climbed 3.5% after the firm reported a 5% rise in first-quarter sales.

Spain's IBEX 35 index gained 0.4% to 8,123.80.

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