HIRU Hiru Corporation (PK)

Hiru Corporation (PINK SHEETS: HIRU) (http://www.hirucorporation.com/), is pleased to announce that researchers from its MindUp BioResearch (www.mindupbioresearch.com), European subsidiary have published their new results of preclinical studies on the topic of overcoming multidrug resistance, a frequent phenomenon occurring in cancer that seriously limit the efficacy of lung cancer course of therapy with chemotherapeutic agents.

Dr Sabera Ruzdijic, the Leader of MindUp Bioresearch Group said: "In this paper we examined the effect of two purine analogs sulfinosine (SF) and 8-Cl-cAMP on cell growth inhibition in parental and resistant human lung carcinoma cell lines. Pretreatment with purine analogues was more potent in improving the sensitivity of resistant lung carcinoma cells to doxorubicin than conventional chemo-sensitizing agent - verapamil (VER). Combinations of either SF or 8-Cl-cAMP with VER at clinically acceptable concentrations exhibited synergistic effects on cell growth inhibition in the resistant lung carcinoma cell line. Together with their ability to reverse multidrug resistance, these results render the purine analogs (in combination with VER) as potential candidates for improving the clinical activity of existing lung cancer therapeutics.

Dr Sabera Ruzdijic added: "We are proud that these results are accepted and published in the prestigious journal Investigational New Drugs (2010) 28:482-492 by Pesic et al. (http://www.springerlink.com/content/w2h2805230314332/)". At the company website http://www.hirucorporation.com/ you can find the PDF of article.

In other company news and updates, MindUp division is currently in negotiation discussions as a buyout candidate. The management is of the opinion that this is a material event that warrants a news release.

More details will follow on the MindUp divestiture as it becomes available.

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Contacts: Hiru Corporation corporate@hirucorporation.com