FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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OMB Number: 3235-0287
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Bove Mauro		 2. Issuer Name and Ticker or Trading Symbol

REGENERX BIOPHARMACEUTICALS INC [ RGRX ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)

C/O REGENERX BIOPHARMACEUTICALS, INC., 15245 SHADY GROVE ROAD, SUITE 470		 3. Date of Earliest Transaction (MM/DD/YYYY)

5/17/2022
(Street)

ROCKVILLE, MD 20850
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (right to buy) $0.3600            (1)6/30/2022 Common Stock 100000  100000 D  
Stock Option (right to buy) $0.6400            (1)3/16/2023 Common Stock 100000  100000 D  
Stock Option (right to buy) $0.2800            (1)9/1/2027 Common Stock 125000  125000 D  
Stock Option (right to buy) $0.2100            (1)7/17/2028 Common Stock 200000  200000 D  
Stock Option (right to buy) $0.2100            (1)5/15/2029 Common Stock 200000  200000 D  
Stock Option (right to buy) $0.3000            (2)6/10/2030 Common Stock 200000  200000 D  
Convertible Promissory Note (right to buy) $0.1200           2/27/2019 2/27/2024 Common Stock 41667  31250 D  
Convertible Promissory Note (right to buy) $0.1200           5/13/2019 5/13/2024 Common Stock 41667  31250 D  
Common Stock Warrant (right to buy) $0.1800           8/27/2019 2/27/2024 Common Stock 31250  20880 D  
Common Stock Warrant (right to buy) $0.1800           11/13/2019 5/13/2024 Common Stock 31250  0 D  
Convertible Promissory Note (right to buy) $0.3600           10/15/2020 10/15/2025 Common Stock 27840  0 D  
Common Stock Warrant (right to buy) $0.4500           4/15/2021 10/15/2025 Common Stock 20880  0 D  
Stock Option (right to buy) $0.2800            (3)8/2/2031 Common Stock 240000  240000 D  
Stock Option (right to buy) $0.19 5/17/2022  A   240000     (4)5/17/2032 Common Stock 240000 $0 240000 D  
Explanation of Responses:
(1) 100% vested.
(2) 50,000 shares vest on each of 6/10/20, 6/10/21, 6/10/22 and 6/10/23.
(3) 60,000 shares vest on each of 8/2/21, 8/2/22, 8/2/23 and 8/2/24.
(4) 120,000 shares vest on each of 5/17/22 and 5/17/23.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Bove Mauro
C/O REGENERX BIOPHARMACEUTICALS, INC.
15245 SHADY GROVE ROAD, SUITE 470
ROCKVILLE, MD 20850		X
Signatures
/s/ Andrew Nick as Attorney-in-Fact for Mauro Bove pursuant to Power of Attorney previously filed.5/19/2022
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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