SCHEDULE 11

NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

 1. Name of company
    Acambis plc
   
 2. Name of director
    Gordon Cameron
   
 3. Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder if it is a
    holding of that person's spouse or children under the age of 18 or in
    respect of a non-beneficial interest
    As above
   
 4. Name of the registered holder(s) and, if more than one holder, the number
    of shares held by each of them (if notified)
    As above
   
 5. Please state whether notification relates to a person(s) connected with the
    Director named in 2 above and identify the connected person(s)
    N/A
   
 6. Please state the nature of the transaction. For PEP transactions please
    indicate whether general/single co PEP and if discretionary/non
    discretionary
    Grant of options under "The Acambis 1999 Share Option Plan"
   
 7. Number of shares/amount of stock acquired
    N/A
   
 8. Percentage of issued class
    N/A
   
 9. Number of shares/amount of stock disposed
    N/A
   
10. Percentage of issued class
    N/A
   
11. Class of security
    N/A
   
12. Price per share
    N/A
   
13. Date of transaction
    N/A
   
14. Date company informed
    N/A
   
15. Total holding following this notification
    N/A
   
16. Total percentage holding of issued class following this notification
    N/A
   
If a director has been granted options by the company please complete the
following boxes

17. Date of grant
    19 December 2003
   
18. Period during which or date on which exercisable
    19 December 2006 - 18 December 2013
   
19. Total amount paid (if any) for grant of the option
    Nil
   
20. Description of shares or debentures involved: class, number
   
32,561 ordinary shares of 10p each

21. Exercise price (if fixed at time of grant) or indication that price is to
    be fixed at time of exercise
   
276p per share

22. Total number of shares or debentures over which options held following this
    notification
    567,916 ordinary shares of 10p each
   
23. Any additional information
    N/A
   
24. Name of contact and telephone number for queries
    Elizabeth Brown 01223 275300
   
25. Name company official responsible for making this notification
   
Elizabeth Brown

SCHEDULE 11

NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

 1. Name of company
    Acambis plc
   
 2. Name of director
    Nicolas Higgins
   
 3. Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder if it is a
    holding of that person's spouse or children under the age of 18 or in
    respect of a non-beneficial interest
    As above
   
 4. Name of the registered holder(s) and, if more than one holder, the number
    of shares held by each of them (if notified)
    As above
   
 5. Please state whether notification relates to a person(s) connected with the
    Director named in 2 above and identify the connected person(s)
    N/A
   
 6. Please state the nature of the transaction. For PEP transactions please
    indicate whether general/single co PEP and if discretionary/non
    discretionary
    Grant of options under "The Acambis 1999 Share Option Plan"
   
 7. Number of shares/amount of stock acquired
    N/A
   
 8. Percentage of issued class
    N/A
   
 9. Number of shares/amount of stock disposed
    N/A
   
10. Percentage of issued class
    N/A
   
11. Class of security
    N/A
   
12. Price per share
    N/A
   
13. Date of transaction
    N/A
   
14. Date company informed
    N/A
   
15. Total holding following this notification
    N/A
   
16. Total percentage holding of issued class following this notification
    N/A
   
If a director has been granted options by the company please complete the
following boxes

17. Date of grant
    19 December 2003
   
18. Period during which or date on which exercisable
    19 December 2006 - 18 December 2013
   
19. Total amount paid (if any) for grant of the option
    Nil
   
20. Description of shares or debentures involved: class, number
   
32,428 ordinary shares of 10p each

21. Exercise price (if fixed at time of grant) or indication that price is to
    be fixed at time of exercise
   
276p per share

22. Total number of shares or debentures over which options held following this
    notification
    493,081 ordinary shares of 10p each
   
23. Any additional information
    N/A
   
24. Name of contact and telephone number for queries
    Elizabeth Brown 01223 275300
   
25. Name company official responsible for making this notification
    Elizabeth Brown
   
SCHEDULE 11

NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

 1. Name of company
    Acambis plc
   
 2. Name of director
    Dr Thomas Monath
   
 3. Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder if it is a
    holding of that person's spouse or children under the age of 18 or in
    respect of a non-beneficial interest
    As above
   
 4. Name of the registered holder(s) and, if more than one holder, the number
    of shares held by each of them (if notified)
    As above
   
 5. Please state whether notification relates to a person(s) connected with the
    Director named in 2 above and identify the connected person(s)
    N/A
   
 6. Please state the nature of the transaction. For PEP transactions please
    indicate whether general/single co PEP and if discretionary/non
    discretionary
    Grant of options under "The Acambis 1999 Share Option Plan"
   
 7. Number of shares/amount of stock acquired
    N/A
   
 8. Percentage of issued class
    N/A
   
 9. Number of shares/amount of stock disposed
    N/A
   
10. Percentage of issued class
    N/A
   
11. Class of security
    N/A
   
12. Price per share
    N/A
   
13. Date of transaction
    N/A
   
14. Date company informed
    N/A
   
15. Total holding following this notification
    N/A
   
16. Total percentage holding of issued class following this notification
    N/A
   
If a director has been granted options by the company please complete the
following boxes

17. Date of grant
    19 December 2003
   
18. Period during which or date on which exercisable
    19 December 2006 - 18 December 2013
   
19. Total amount paid (if any) for grant of the option
    Nil
   
20. Description of shares or debentures involved: class, number
   
30,752 ordinary shares of 10p each

21. Exercise price (if fixed at time of grant) or indication that price is to
    be fixed at time of exercise
   
276p per share

22. Total number of shares or debentures over which options held following this
    notification
    486,910 ordinary shares of 10p each
   
23. Any additional information
    N/A
   
24. Name of contact and telephone number for queries
    Elizabeth Brown 01223 275300
   
25) Name company official responsible for making this notification
Elizabeth Brown



END