RNS Number:2348V
Cobra Bio-Manufacturing PLC
10 February 2004

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1.     Name of company

       Cobra Bio-Manufacturing plc

2.     Name of shareholder having a major interest

       Unicorn Investment Funds ICVC

3.     Please state whether notification indicates that it is in respect of 
       holding of the shareholder named in 2 above or in respect of a 
       non-beneficial interest or in the case of an individual holder if it is a 
       holding of that person's spouse or children under the age of 18.

       As above

4.     Name of the registered holder(s) and, if more than one holder, the number 
       ofshares held by each of them

       HSBC Nominees Limited a/c Unicorn Investment Funds UK Smaller Companies 
       Fund & Unicorn Free Spirit Fund

5.     Number of shares/amount of stock acquired

       151,013

6.     Percentage of issued class

       Not stated

7.     Number of shares/amount of stock disposed

       N/A

8.     Percentage of issued class

       N/A

9.     Class of security

       Ordinary Shares of 10p each

10.    Date of transaction

       4thFebruary 2004

11.    Date company informed

       10th February 2004

12.    Total holding following this notification

       651,013 shares

13.    Total percentage holding of issued class following this notification

       3.339%

14.    Any additional information

15.    Name of contact and telephone number for queries

       Tracey Pughe  - Tel: 01782 714181

16.    Name and signature of authorised company official responsible for making 
       this notification.

   Tracey Pughe

       Date of notification: 10th February 2004




                      This information is provided by RNS
            The company news service from the London Stock Exchange
END

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