TIDMIMM

RNS Number : 8715K

Immupharma PLC

31 August 2023

RNS: RELEASE | 31 August 2023

ImmuPharma PLC

("ImmuPharma" or the "Company")

INTERIM RESULTS

for the six months ended 30 June 2023

ImmuPharma PLC (LSE:IMM) , ("ImmuPharma" or the "Company"), the specialist drug discovery and development company, is pleased to announce its interim results for the six months ended 30 June 2023 (the "Period").

Key Highlights (including post Period review)

Financials

   --   Loss for the Period of GBP0.8m (30 June 2022:  GBP1.7m) 
   --   Research and development expenses of GBP0.8m (30 June 2022: GBP1.0m) 
   --   Administrative expenses of GBP0.4m (30 June 2022: GBP0.6m) 
   --   Share based expense of GBP0.1m (30 June 2022: GBP0.1m) 
   --   Cash balance of GBP0.2m as at 30 June 2023 (31 December 2022:  GBP0.2m) 
   --   Derivative financial asset of GBP0.6m as at 30 June 2023 (31 December 2022: GBP0.6m) 
   --   Basic and diluted loss per share of 0.25p (30 June 2022: 0.58p) 
   --   Successful fundraising - see separate announcement today 

Portfolio

-- In February 2023 an adaptive Phase 2/3 study for Lupuzor(TM) in SLE/Lupus patients was agreed with US partner, Avion Pharmaceuticals.

   --    In March 2023 a collaboration with Orano SA on ImmuPharma's peptide technology was announced. 

-- In May 2023, ImmuPharma received positive guidance from the Food and Drug Administration ("FDA") following the Pre-Investigational New Drug ("PIND") meeting supporting a Phase 2/3 adaptive clinical study of P140 in CIDP.

-- In June 2023, confirmation that following receipt of comprehensive guidance from the FDA, a Phase 2/3 adaptive clinical trial of P140 (Lupuzor(TM)) in patients with Lupus will commence in H2 2023.

-- Established discussions with new potential corporate partners across the P140 platform and anti-infective programmes.

Corporate

   --    In August 2023, the Board was strengthened with two NED appointments: Dr Laurence Reilly & Dr Sébastien Goudreau. 

Commenting on the statement and outlook Tim McCarthy, CEO and Chairman, said :

"We continue to make positive progressive steps for ImmuPharma. As a Board, we remain focused on bringing our two key late stage P140 clinical assets in Lupus and CIDP through their final clinical trials and to the market.

The drive to conclude further commercial and partnering deals will be accelerated over this next period and which is now bolstered by the recently announced new Board appointments.

The Board would like to take this opportunity to thank its shareholders for their continued patience and support, as well as its staff, corporate and scientific advisers and our partners including CNRS and Avion."

Market Abuse Regulation (MAR) Disclosure

THIS ANNOUNCEMENT CONTAINS INSIDE INFORMATION AS STIPULATED UNDER THE UK VERSION OF THE MARKET ABUSE REGULATION NO 596/2014 WHICH IS PART OF UK LAW BY VIRTUE OF THE EUROPEAN UNION (WITHDRAWAL) ACT 2018, AS AMED. ON PUBLICATION OF THIS ANNOUNCEMENT VIA A REGULATORY INFORMATION SERVICE, THIS INFORMATION IS CONSIDERED TO BE IN THE PUBLIC DOMAIN.

 
 
    For further information please contact: 
      ImmuPharma PLC (www.immupharma.co.uk)                  + 44 (0) 2072 062650 
      Tim McCarthy, Chief Executive Officer and Chairman 
      Lisa Baderoon, Head of Investor Relations              + 44 (0) 7721 413496 
      SPARK Advisory Partners Limited (NOMAD) 
       Neil Baldwin                                          +44 (0) 203 36 8 8974 
 
       Stanford Capital Partners (Joint Broker) 
       Patrick Claridge, Bob Pountney                         +44 (0) 203 815 8880 
 
       SI Capital (Joint Broker) 
       Nick Emerson                                           +44 (0) 1483 413500 
 

A copy of the interim report is available on the Company's website www.immupharma.co.uk

ImmuPharma plc

INTERIM RESULTS

FOR THE SIX MONTH PERIODED 30 JUNE 2023

ImmuPharma plc

Chairman's Statement

The first part of 2023 was a period of further progress for ImmuPharma, as we continued to focus on progressing our late-stage pipeline assets specifically, within our P140 autoimmune platform.

Most recently in June, the Company announced that, after receiving comprehensive guidance from the Food and Drug Administration ("FDA") on the new Phase 2/3 adaptive clinical trial protocol for the lead programme for the treatment of patients with systemic lupus erythematosus ("SLE/Lupus"), it is moving forward with the study, together with its US partner Avion Pharmaceuticals ("Avion").

Positive progress was also announced in May for a second high medical need disease, chronic idiopathic demyelinating polyneuropathy ("CIDP"). The Company received positive feedback from the FDA at a pre-IND meeting for a late-stage Phase 2/3 adaptive clinical program in patients, which is a further debilitating auto-immune condition within the Company's P140 platform.

In parallel with advancements in the late-stage clinical developments, the Company is also actively in discussions with a number of potential commercial partners for programmes across the Company's development portfolio.

Lupuzor(TM)/P140 - opportunity and next steps

There are an estimated five million people suffering from Lupus, with approximately 5 million patients in the US, Europe and Japan (Source: Lupus Foundation of America). The prevalence in China may be 2-3 times that seen in the US. Current 'standard of care' treatments, including steroids and immunosuppressants, can potentially have either serious side effects for patients or limited efficacy, with over 60 per cent of patients not adequately treated.

ImmuPharma believes Lupuzor(TM)/P140 has the potential to be a novel specific drug therapy for the treatment of Lupus by specifically modulating the immune system and halting disease progression in most Lupus patients. It has a unique mechanism of action and is not an immunosuppressant like other drugs. Lupuzor(TM)/P140 normalises the over-activity of T-cells which are involved in the immune response leading to Lupus disease. Lupuzor(TM) taken over the long term may have the potential to prevent the progression of Lupus rather than just treating its symptoms, with the rest of the immune system retaining the ability to work normally.

A new major opportunity for P140 is CIDP, a rare acquired autoimmune disorder of peripheral nerves. It is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. CIDP is a potential orphan drug indication which would provide patent life extension of 7 years post-approval.

The Board is confident that there is a route to market for P140 in Lupus and CIDP including further corporate collaborations.

Lupuzor(TM) Phase 2/3 Adaptive Study

As announced in June 2023, following the receipt of comprehensive guidance from the FDA, in conjunction with our US partner Avion, a Phase 2/3 adaptive clinical trial of P140 (Lupuzor(TM)) in patients with Lupus will commence in H2 2023.

The trial design and protocol is substantially different from previous clinical trials that ImmuPharma has completed and includes maintaining subcutaneous dosing but at much higher concentrations and significant changes to patient inclusion criteria and primary and secondary clinical endpoints.

The detailed protocol and key elements of the clinical trial design will be communicated at a later stage once the details of the trial are available on clinicaltrials.gov (a comprehensive database of privately and publicly funded clinical studies conducted around the world).

Lupus ABC Consortium

The FDA's Center for Drug Evaluation and Research ("CDER") has partnered with the Lupus Research Alliance ("LRA") to launch the Lupus Accelerating Breakthroughs Consortium ("Lupus ABC"), a first-of-its-kind public-private partnership focused on addressing challenges impacting Lupus clinical trial success.

Lupus ABC will convene people living with Lupus, medical societies, industry, academic clinical researchers and scientists, FDA, and other federal agencies to address scientific hurdles that are beyond the capacity of any single entity. By connecting those with lived experience with all parties involved in Lupus treatment research, CDER hopes to advance the development of urgently needed treatments for Lupus.

This can only be extremely good news for Lupus patients worldwide, including ImmuPharma, our partners and our peers, in bringing new safe Lupus drugs to the market, sooner rather than later.

CIDP / P140

For P140 in CIDP we announced in April 2023 that we had received confirmation from the FDA for a pre- Investigational New Drug ("PIND") meeting date of 16 May 2023, to consider a Phase 2/3 adaptive trial study protocol.

In May 2023, ImmuPharma received positive guidance from FDA following the PIND meeting that confirms the route for a Phase 2/3 adaptive clinical study of P140 in CIDP.

The FDA feedback recognises that P140 is suitable to be studied in another disease indication in addition to SLE and this strongly supports the underlying science and mechanism of action of P140 across several auto-immune/inflammatory diseases and is a significant breakthrough for the P140 platform.

The Phase 2/3 adaptive clinical trial will be the first pivotal stage study of P140 in patients with CIDP: a rare neurological disease with high medical need.

An IND application is now being prepared for submission to the FDA, incorporating all guidance points. An application for Orphan Drug status for CIDP will be also submitted in parallel to the full IND application.

The CIDP market is expected to reach global sales of US$2.7bn by 2029.

Anti-Infection

The innovative peptide technology at ImmuPharma Biotech has been a huge success and very recently has given rise to a number of novel development programs, out of which we have identified two core programs: BioAMB and BioCin, which we believe have the best commercial opportunity and speed to market. These programs are based on existing drugs that have been used for decades so the PK, efficacy and safety of those drugs is well understood. They will also be patent protected.

o BioAMB, a novel peptide-based drug that offers a potential improvement on the limiting side effects and poor administration regime of current Amphotericin-B ("AMB") formulations. AMB is one of a last line of agents against serious and life-threatening fungal infections caused by the aspergillus family of fungi.

o BioCin, a novel peptide-based drug based on an existing potent antibacterial, vancomycin, used in high medical need cases and in many cases the last line of defense. BioCin has the potential to offer improved safety and administration benefits.

Pipeline Overview

Our therapeutic focus is on two core areas; Autoimmunity/Inflammation and Anti-infection. We also look for valuable deals for non-core assets as evidenced by a collaborative deal, signed in March 2023, with Orano SA on ImmuPharma's peptide technology as a vector for cancer radiotherapy. The initial collaboration is for 12 months, and a small undisclosed upfront payment was paid to ImmuPharma.

Commercial Activities

Management has established discussions with new potential corporate partners across the P140 platform and anti-infective programmes. The drive to conclude further commercial and partnering deals will be accelerated over this next period and which is now bolstered by the recently announced new Board appointments.

Centre National de la Recherche Scientifique (CNRS)

ImmuPharma continues to have important collaboration arrangements with the Centre National de la Recherche Scientifique ("CNRS"), the French National Council for Scientific Research and the largest basic research organisation in Europe. This is where Lupuzor(TM) /P140 platform was invented by Prof. Sylviane Muller, Emeritus Research Director at the CNRS.

Interest in Incanthera Plc

As at 30 June 2023, ImmuPharma had a 12.7% interest in oncology specialist, Incanthera plc, which trades on Aquis Stock Exchange ("AQSE") under the ticker (TIDM:INC).

ImmuPharma also has 7,272,740 warrants in Incanthera at an exercise price of 9.5p. As most recently announced in August 2023, the term of these Warrants has been extended by 12 months to 6 September 2024.

As announced in Incanthera's interim report in December 2022, the Company continues to concentrate upon furthering discussions to capitalise on the potential for various applications of its skincare portfolio for commercial success.

As a major shareholder, ImmuPharma remains supportive of Incanthera.

Capital subscription post period end

The Company has undertaken a successful fundraising post period ended; see the separate announcement issued today.

Current Activities and Outlook

"We continue to make positive progressive steps for ImmuPharma. As a Board, we remain focused on bringing our two key late stage P140 clinical assets in Lupus and CIDP through their final clinical trials and to the market.

The drive to conclude further commercial and partnering deals will be accelerated over this next period and which is now bolstered by the recently announced new Board appointments.

The Board would like to take this opportunity to thank its shareholders for their continued patience and support, as well as its staff, corporate and scientific advisers and our partners including CNRS and Avion."

Tim McCarthy

Chairman & Chief Executive Officer

31 August 2023

ImmuPharma plc

CONSOLIDATED INCOME STATEMENT

FOR THE PERIODED 30 JUNE 2023

 
                                               Unaudited         Audited      Unaudited 
                                                6 months      Year ended       6 months 
                                                   ended     31 December          ended 
                                     Note        30 June            2022        30 June 
                                                    2023                           2022 
                                                     GBP             GBP            GBP 
  Continuing operations 
  Revenue                                         69,959               -              - 
  Research and development                                   ( 2,022,507 
   expenses                                    (828,767)               )    (1,042,917) 
                                                               ( 846,571 
  Administrative expenses                      (412,277)               )      (555,600) 
                                                               ( 159,874 
  Share based expense                          (127,327)               )       (70,994) 
 
                                                              (3,028,952 
    Operating loss                           (1,298,412)               )    (1,669,511) 
 
  Finance costs                      6             (931)     (1,455,966)      (176,665) 
  Finance income                                 162,286        (28,585)         16,364 
 
 
  Loss before taxation                       (1,137,057)     (4,456,333)    (1,829,812) 
 
  Tax                                            289,691         648,902        166,024 
 
 
  Loss for the period                          (847,366)     (3,807,431)    (1,663,788) 
 
 
  Attributable to: 
  Equity holders of the parent 
   company                                     (847,366)     (3,807,431)    (1,663,788) 
 
 
  Loss per ordinary share 
 
  Basic and diluted                  2           (0.25)p         (1.26)p        (0.58)p 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

FOR THE PERIODED 30 JUNE 2023

 
                                            Unaudited         Audited      Unaudited 
                                             6 months            Year       6 months 
                                                ended           ended          ended 
                                              30 June     31 December        30 June 
                                                 2023            2022           2022 
                                                  GBP             GBP            GBP 
 
  Loss for the financial period             (847,366)     (3,807,431)    (1,663,788) 
 
 
  Other comprehensive income 
  Items that will not be reclassified 
   subsequently to profit or loss: 
  Fair value loss on investment              (54,474)       (519,977)      (614,068) 
  Fair value loss on warrants                   7,421       (206,279)      (206,411) 
 
 
  Total items that will not be 
   reclassified subsequently to 
   profit or loss                            (47,053)       (726,256)      (820,479) 
 
 
  Items that may be reclassified 
   subsequently to profit or loss: 
  Exchange differences on translation 
   of foreign operations                     (18,897)          79,104         16,350 
 
 
  Total items that may be reclassified 
   subsequently to profit or loss            (18,897)          79,104         16,350 
 
  Other comprehensive loss for 
   the period                                (65,950)       (647,152)      (804,129) 
 
 
  Total comprehensive loss for 
   the period                               (913,316)     (4,454,583)    (2,467,917) 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

AS AT 30 JUNE 2023

 
                                    Note       Unaudited              Audited            Unaudited 
                                                6 months                 Year             6 months 
                                                   ended                ended                ended 
                                                 30 June          31 December              30 June 
                                                    2023                 2022                 2022 
                                                     GBP                  GBP                  GBP 
  Non-current assets 
  Intangible assets                              463,207              473,892              471,534 
  Property, plant and equipment                  332,992              389,716              330,835 
   Financial asset                               642,526              689,579              595,355 
  Derivative financial asset         4            36,466               82,563              196,488 
 
 
  Total non-current assets                     1,475,191            1,635,750            1,594,212 
 
 
  Current assets 
  Trade and other receivables                    705,867              723,583              114,450 
  Cash and cash equivalents                      210,584              667,813              170,922 
  Current tax asset                              624,429              695,297              595,205 
  Derivative financial asset         4           272,388              252,258              400,306 
 
 
  Total current assets                         1,813,268            2,338,951            1,280,883 
 
 
  Current liabilities 
  Financial liabilities - 
   borrowings                                          -                (111)                (230) 
  Trade and other payables                   (1,551,071)          (1,451,213)            (858,291) 
 
 
  Total current liabilities                  (1,551,071)           1,451,324)            (858,521) 
 
 
  Net current assets                             262,197              887,627              422,362 
 
 
 
 
  Net assets                                   1,737,388            2,523,377            2,016,574 
 
 
  EQUITY 
  Ordinary shares                    5        28,982,676           28,982,676            28,498,94 
  Share premium                               28,788,377           28,788,377           27,237,329 
  Merger reserve                                 106,148              106,148              106,148 
  Other reserves                               5,869,926            5,761,496            5,240,503 
  Retained earnings                         (62,009,739)         (61,115,320)         (59,065,900) 
 
 
  Total equity                                 1,737,388            2,523,377            2,016,574 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

FOR THE PERIODED 30 JUNE 2023

 
 
 
 
 
 
                                                                                                          Other 
                                                                     Other                   Other     reserves        Other 
                                                                  reserves                reserves       -Share     reserves 
                                         Share      Merger               -                       -        based            -        Retained 
                        Ordinary       premium     Reserve     Acquisition             Translation      payment      Warrant         Earning            Total 
                          shares           GBP         GBP         Reserve                 Reserve      reserve      reserve            GBPs           Equity 
                             GBP                                       GBP                     GBP          GBP          GBP                              GBP 
   At 1 January 
    2022              28,498,494    27,237,329     106,148     (3,541,203)             (1,344,657)    8,690,019    1,349,000    (56,581,633)        4,413,497 
   Loss for the 
    financial 
    period                     -             -           -               -                       -            -            -     (1,663,788)      (1,663,788) 
   Exchange                                                                                 16,350 
    differences                -             -           -               -                       -            -            -               -           16,350 
   Share based 
    payments                   -             -           -               -                       -       70,994            -               -           70,994 
   Fair value 
    loss 
    on 
    investments                -             -           -               -                       -            -            -       (614,068)        (614,068) 
   Fair value 
    loss 
    on warrants                -             -           -               -                       -            -            -       (206,411)        (206,411) 
   At 30 June 
    2022 
    unaudited         28,498,494    27,237,329     106,148     (3,541,203)             (1,328,307)    8,761,013    1,349,000    (59,065,900)        2,016,574 
                 ---------------  ------------  ----------  --------------  ----------------------  -----------  -----------  --------------  --------------- 
 
   At 1 January 
    2022              28,498,494    27,237,329     106,148     (3,541,203)             (1,344,657)    8,690,019    1,349,000    (56,581,633)        4,413,497 
   Loss for the 
    financial 
    year                       -             -           -               -                       -            -                  (3,807,431)      (3,807,431) 
   Exchange 
    differences                -                         -               -                  79,104            -            -               -         (79,104) 
   Share based 
    payments                   -             -           -               -                       -      159,874            -               -          159,874 
   New issue of 
    equity 
    capital              484,182     1,866,727           -               -                       -            -            -               -        2,350,909 
   Cost of new 
    issue 
    of equity 
    capital                    -     (165,679)           -               -                       -            -            -               -        (165,679) 
   Fair value 
    loss 
    o n 
    investments                -             -           -               -                       -            -            -       (519,977)        (519,977) 
   Fair value 
    loss 
    on warrants                -             -           -               -                       -            -            -       (206,279)        (206,279) 
   Issue of 
    warrants                         (150,000)                                                                       369,359               -          219,359 
   At 31 
    December 
    2022 & 1 
    January 
    2023 
    audited           28,982,676    28,788,377     106,148     (3,541,203)             (1,265,553)    8,849,893    1,718,359    (61,115,320)        2,523,377 
                 ---------------  ------------  ----------  --------------  ----------------------  -----------  -----------  --------------  --------------- 
 
   Loss for the 
    financial 
    period                     -             -           -               -                       -            -            -       (847,366)      (1,663,788) 
   Exchange 
    differences                -             -           -               -                (18,897)            -                            -           16,350 
   Share split                 -                                                                                                                            - 
   Share based 
    payments                   -             -           -               -                       -      127,327            -               -           70,994 
   Fair value 
    loss 
    on 
    investments                -             -           -               -                       -            -            -        (54,475)        (614,068) 
   Fair value 
    gain 
    on warrants                -             -           -               -                       -            -            -           7,421        (206,411) 
                 ---------------  ------------  ----------  --------------  ----------------------  -----------  -----------  --------------  --------------- 
   At 30 June 
    2023 
    unaudited         28,982,676    28,788,377     106,148     (3,541,203)             (1,284,450)    8,977,220    1,718,359    (62,009,739)        1,737,388 
                 ---------------  ------------  ----------  --------------  ----------------------  -----------  -----------  --------------  --------------- 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CASHFLOWS

FOR THE PERIODED 30 JUNE 2023

 
                                        Note    Unaudited                    Audited      Unaudited 
                                                 6 months                       Year       6 months 
                                                    ended                      ended          ended 
                                                  30 June                31 December        30 June 
                                                     2023                       2022           2022 
                                                      GBP                        GBP            GBP 
  Cash flows from operating 
   activities 
  Cash used in operations                3      (990,977)                (3,224,906)    (1,966,598) 
 
    Tax received                                  338,992                    879,877        343,246 
  Interest paid                                     (932)                    (2,036)          (922) 
 
 
    Net cash used in operating 
    activities                                  (652,917)                (2,347,065)    (1,624,274) 
 
 
  Investing activities 
  Purchase of property, 
   plant and equipment                                  -                 ( 106,009)              - 
  Interest received                                 1,464                     28,585             63 
 
  Net cash (used in)/generated 
   from investing activities                        1,464                   (77,424)             63 
 
 
  Financing activities 
  Decrease in bank overdraft                        (109)                          -              - 
  New loans/(loan repayments)                           -                          -          (470) 
  Settlements from Sharing 
   Agreement                                      184,951                    362,500        143,273 
  Gross proceeds from issue                             -                  2,350,909              - 
   of new share capital 
  Share capital issue costs                             -                  (165,679)              - 
  Funds deferred per Sharing                            -                (1,000,000)              - 
   Agreement 
 
 
  Net cash generated from financing 
   activities                                     184,842                  1,547,730        142,803 
 
  Net (decrease) in cash and 
   cash equivalents                             (466,612)                  (876,759)    (1,481,408) 
  Cash and cash equivalents 
   at start of period                             667,813                  1,649,374      1,649,374 
 
    Effects of exchange rates 
    on cash and 
    cash equivalents                                9,382                  (104,802)          2,956 
 
 
    Cash and cash equivalents 
    at end of period                              210,583                    667,813        170,922 
 
 
 

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIODED 30 JUNE 2023

   1          ACCOUNTING POLICIES 

Basis of preparation

The interim financial information in this report has been prepared using accounting policies consistent with IFRS as adopted by the United Kingdom. IFRS is subject to amendment and interpretation by the International Accounting Standards Board (IASB) and the IFRS Interpretations Committee and there is an ongoing process of review and endorsement by the UK Endorsement Board. The financial information has been prepared on the basis of IFRS expected to be adopted by the United Kingdom and applicable as at 31 December 2022. The Group has chosen not to adopt IAS 34 "Interim Financial Statements" in preparing the interim financial information.

The accounting policies applied are consistent with those that were applied to the financial statements for the year ended 31 December 2022.

Non-Statutory accounts

The financial information set out in this interim report does not constitute the Group's statutory accounts, within the meaning of Section 434 of the Companies Act 2006. The statutory accounts for the year ended 31 December 2022 have been filed with Registrar of Companies. The auditors reported on those accounts; their report was unqualified, did not contain a statement under either Section 498 (2) or Section 498 (3) of the Companies Act 2006 but did include emphasis of matter paragraph relating to the carrying value of Parent Company's investment in subsidiaries and receivables due from group undertakings, and a reference to which the auditor drew attention by way of emphasis without qualifying their report in respect of going concern.

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2023

(Continued)

   2              LOSS PER SHARE 
 
                                          Unaudited         Audited      Unaudited 
                                           6 months            Year       6 months 
                                              ended           ended          ended 
                                            30 June     31 December        30 June 
                                               2023            2022           2022 
                                                GBP             GBP            GBP 
 
  Loss 
  Loss for the purposes of basic 
   and diluted loss per share 
   being net loss attributable 
   to equity shareholders                 (847,366)     (3,807,431)    (1,663,788) 
 
 
  Number of shares 
  Weighted average number of 
   ordinary shares for the purposes 
   of basic loss per share              333,403,115    302,912,903     284,984,933 
 
 
 
    Basic loss per share                    (0.25)p         (1.26)p        (0.58)p 
 
 
 
  Diluted loss per share                    (0.25)p         (1.26)p        (0.58)p 
 
 
 

There is no difference between basic loss per share and diluted loss per share as the share options and warrants are anti-dilutive. Deferred shares are excluded from the loss per share calculation as they have no attributable earnings.

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2023

(Continued)

 
  3                                 CASH USED IN OPERATIONS 
                                               Unaudited          Audited          Unaudited 
                                                6 months             Year           6 months 
                                                   ended            ended              ended 
                                                 30 June      31 December            30 June 
                                                    2023             2022               2022 
                                                     GBP              GBP                GBP 
 
   Operating loss                            (1,298,417)      (3,028,952)        (1,669,511) 
   Depreciation & amortisation                    58,787          117,563              86,639 
   Share based payments                          127,327          159,874            288,826 
   Decrease/(increase) in trade 
    & other receivables                           17,716        (132,392)            312,749 
   Increase/(decrease) in trade 
    & other payables                              99,858        (296,384)          (725,313) 
   Gain / (loss) on 
    foreign exchange                               3,752         (45,554)              7,271 
 
 
     Cash used in operations                   (990,977)      (3,224,906)        (1,966,598) 
 
 
 
 
  4    Derivative Financial Asset 
 
        As part of the placement completed in March 2020, the Company 
        issued 13,000,000 new ordinary shares to Lanstead Capital 
        Investors L.P. ("Lanstead") at a price of 10p per share 
        for an aggregate subscription price of GBP1.3m before expenses. 
        In December 2021, the Company issued 20,000,000 new ordinary 
        shares to Lanstead at a price of 11p per share to raise 
        GBP2.2m before expenses. In the placement completed in August 
        2022, the Company issued 20,000,000 new ordinary shares 
        to Lanstead at a price of 5p per share to raise GBP1m gross. 
        All Subscriptions proceeds were pledged under Sharing Agreements, 
        under which Lanstead made and will continue to make, subject 
        to the terms and conditions of the respective Sharing Agreement, 
        monthly settlements to the Company that are subject to adjustment 
        upwards or downwards depending on the Company's share price 
        performance. 
 
        In December 2021 and August 2022 the Company also issued 
        1,400,000 new ordinary shares consecutively to Lanstead 
        as value payments in connection with the Share Subscriptions 
        and the Sharing Agreements. Monthly settlements under the 
        Sharing Agreement from March 2020 completed in June 2022. 
        The settlements from remaining Sharing Agreements (December 
        2021 and August 2022) will continue until 2024, completing 
        in March 2024 and August 2024 respectively. 
 
        At the end of the accounting period the amount receivable 
        has been adjusted to fair value based upon the share price 
        of the Company at that date. Any change in the fair value 
        of the derivative financial asset is reflected in the income 
        statement. As at 30 June 2023, the Company completed a calculation 
        of fair value of the derivative financial asset that resulted 
        in a finance gain of GBP142,439 (GBP174,742 loss at 30 June 
        2022), which was recorded in the income statement. The restatement 
        to fair value will be calculated at the end of each accounting 
        period during the course of each Sharing Agreement and will 
        vary according to the Company's share price performance. 
 

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2023

(Continued)

 
 
 
 
 
 
   5              Issued share capital 

At 30 June 2023, the Company had no limit on its authorised share capital.

 
  Allotted, called up              30 June        31 December    30 June       31 December 
   and fully paid                   2023 No.       2022 No.       2023 GBP      2022 GBP 
  At start of year: 
                                 -------------  -------------  ------------  ------------- 
  Ordinary shares of GBP0.10 
   each 
                                 -------------  -------------  ------------  ------------- 
  Ordinary shares of GBP0.01 
   each                            333,403,115    284,984,933     3,334,032      2,849,849 
                                 -------------  -------------  ------------  ------------- 
  Deferred shares of GBP0.09 
   each                            284,984,933    284,984,933    25,648,644     25,648,644 
                                 -------------  -------------  ------------  ------------- 
  Movements during period: 
                                 -------------  -------------  ------------  ------------- 
  Shares issued on 23 
   December 2021 
                                 -------------  -------------  ------------  ------------- 
  Shares issued on 16 
   August 2022                               -     42,418,182             -        424,183 
                                 -------------  -------------  ------------  ------------- 
  Shares issued on 30 
   August 2022                               -      1,000,000             -         10,000 
                                 -------------  -------------  ------------  ------------- 
  Shares issued on 5 September 
   2022                                      -      2,000,000             -         20,000 
                                 -------------  -------------  ------------  ------------- 
  Shares issued on 13 
   September 2022                            -      3,000,000             -         30,000 
                                 -------------  -------------  ------------  ------------- 
  At end of the period             618,388,048    618,388,048    28,982,676     28,982,676 
                                 -------------  -------------  ------------  ------------- 
 
   6.             Subsequent events 

Successful fundraising, see separate announcement issued today

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END

IR EANPEDSLDEFA

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August 31, 2023 02:00 ET (06:00 GMT)

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