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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
_____________________
FORM 10-Q
______________________
| | | | | |
x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the quarterly period ended March 31, 2024
Or
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o | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the transition period from ___________ to ___________
Commission File Number: 001-16133
______________________
DELCATH SYSTEMS, INC.
(Exact name of registrant as specified in its charter)
______________________
| | | | | |
Delaware | 06-1245881 |
(State or other jurisdiction of incorporation or organization) | (I.R.S. Employer Identification No.) |
566 Queensbury Avenue
Queensbury, NY 12804
(Address of principal executive offices)
(212) 489-2100
(Registrant’s telephone number, including area code)
______________________
Securities registered pursuant to Section 12(b) of the Act:
| | | | | | | | | | | | | | |
Title of each class | | Trading Symbol(s) | | Name of each exchange on which registered |
Common stock, $0.01 par value per share | | DCTH | | The Nasdaq Capital Market |
______________________
Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No o
Indicate by check mark whether the registrant has submitted electronically, every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes x No o
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Large accelerated filer | o | | Accelerated filer | o |
| | | | |
Non-accelerated filer | x | | Smaller reporting company | x |
| | | | |
| | | Emerging growth company | o |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Securities Act. o
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes o No x
As of May 9, 2024, 27,785,803 shares of the Company’s common stock, $0.01 par value, were outstanding.
DELCATH SYSTEMS, INC.
Table of Contents
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DELCATH SYSTEMS, INC.
Condensed Consolidated Balance Sheets
(Unaudited)
(in thousands, except share and per share data)
| | | | | | | | | | | |
| March 31, 2024 | | December 31, 2023 |
Assets | | | |
Current assets | | | |
Cash and cash equivalents | $ | 11,760 | | | $ | 12,646 | |
Restricted cash | 50 | | | 50 | |
Short-term investments | 15,360 | | | 19,808 | |
Accounts receivable, net | 1,564 | | | 241 | |
Inventory | 3,634 | | | 3,322 | |
Prepaid expenses and other current assets | 1,278 | | | 1,091 | |
Total current assets | 33,646 | | | 37,158 | |
Property, plant and equipment, net | 1,336 | | | 1,352 | |
Right-of-use assets | 1,117 | | | 103 | |
Total assets | $ | 36,099 | | | $ | 38,613 | |
Liabilities and Stockholders’ Equity | | | |
Current liabilities | | | |
Accounts payable | $ | 1,487 | | | $ | 1,012 | |
Accrued expenses | 4,395 | | | 5,249 | |
Lease liabilities, current | 102 | | | 37 | |
Loan payable | 2,408 | | | 5,239 | |
Convertible notes payable | 4,949 | | | 4,911 | |
Total current liabilities | 13,341 | | | 16,448 | |
Warrant liability | 6,160 | | | 5,548 |
Lease Liabilities, non-current | 1,016 | | | — | |
Other liabilities, non-current | 962 | | | 840 | |
Total liabilities | 21,479 | | | 22,836 | |
Commitments and contingencies (see Note 15) | | | |
Stockholders’ equity | | | |
Preferred stock, $0.01 par value; 10,000,000 shares authorized; 16,809 and 24,819 shares issued and outstanding at March 31, 2024 and December 31, 2023, respectively | — | | | — | |
Common stock, $0.01 par value; 80,000,000 shares authorized; 25,439,319 shares and 22,761,554 shares issued and outstanding at March 31, 2024 and December 31, 2023, respectively | 254 | | | 228 | |
Additional paid-in capital | 530,482 | | | 520,576 | |
Accumulated deficit | (516,273) | | | (505,162) | |
Accumulated other comprehensive loss | 157 | | | 135 | |
Total stockholders’ equity | 14,620 | | | 15,777 | |
Total liabilities and stockholders’ equity | $ | 36,099 | | | $ | 38,613 | |
See accompanying Notes to Condensed Consolidated Financial Statements.
DELCATH SYSTEMS, INC.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(Unaudited)
(in thousands, except share and per share data)
| | | | | | | | | | | |
| Three months ended March 31, |
| 2024 | | 2023 |
Product revenue | $ | 3,139 | | | $ | 597 | |
Other revenue | — | | | — | |
Total revenues | 3,139 | | | 597 | |
Cost of goods sold | (903) | | | (181) | |
Gross profit | 2,236 | | | 416 | |
Operating expenses: | | | |
Research and development expenses | 3,700 | | | 4,576 | |
Selling, general and administrative expenses | 8,814 | | | 4,165 | |
Total operating expenses | 12,514 | | | 8,741 | |
Operating loss | (10,278) | | | (8,325) | |
Change in fair value of warrant liability | (612) | | | — | |
Interest expense, net | (199) | | | (688) | |
Other (expense) income | (22) | | | 13 | |
Net loss | (11,111) | | | (9,000) | |
Other comprehensive (loss) income: | | | |
Unrealized gain on investments | 8 | | | — | |
Foreign currency translation adjustments | 14 | | | 19 | |
Total comprehensive loss | $ | (11,089) | | | $ | (8,981) | |
Common share data: | | | |
Basic and diluted loss per common share | $ | (0.45) | | | $ | (0.77) | |
Weighted average number of basic and diluted shares outstanding | 24,887,180 | | 11,622,384 |
See accompanying Notes to Condensed Consolidated Financial Statements.
DELCATH SYSTEMS, INC.
Condensed Consolidated Statements of Stockholders’ Equity (Deficit)
(Unaudited)
(in thousands, except share data)
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| Three Months ended March 31, 2024 |
| Preferred Stock $0.01 Par Value | | Common Stock $0.01 Par Value | | Additional Paid in Capital | | Accumulated Deficit | | Accumulated Other Comprehensive Income (Loss) | | Total |
| No. of Shares | | Amount | | No. of Shares | | Amount | | | | |
Balance at January 1, 2024 | 24,819 | | $ | — | | | 22,761,554 | | $ | 228 | | | $ | 520,576 | | | $ | (505,162) | | | $ | 135 | | | $ | 15,777 | |
Compensation expense for issuance of stock options | — | | — | | | — | | — | | | 2,895 | | | — | | | — | | | 2,895 | |
Compensation expense for Employee Stock Purchase Plan | — | | — | | — | | — | | 50 | | — | | — | | 50 |
Private placement -issuance of common shares, net of expenses | — | | — | | | 876,627 | | 8 | | | 6,904 | | | — | | | — | | | 6,912 | |
Issuance of common stock with the employee stock purchase plan | — | | — | | | 21,140 | | — | | | 74 | | | — | | | — | | | 74 | |
Conversion - Preferred to Common F-3 | (8,010) | | — | | 1,779,998 | | 18 | | (17) | | — | | — | | 1 |
Net loss | — | | — | | | — | | — | | | — | | | (11,111) | | | — | | | (11,111) | |
Unrealized gain on investments | — | | — | | — | | — | | — | | — | | 8 | | 8 |
Foreign currency translation adjustments | — | | — | | | — | | — | | | — | | | — | | | 14 | | | 14 | |
Balance at March 31, 2024 | 16,809 | | $ | — | | | 25,439,319 | | $ | 254 | | | $ | 530,482 | | | $ | (516,273) | | | $ | 157 | | | $ | 14,620 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| Three Months ended March 31, 2023 |
| Preferred Stock $0.01 Par Value | | Common Stock $0.01 Par Value | | Additional Paid in Capital | | Accumulated Deficit | | Accumulated Other Comprehensive Income (Loss) | | Total |
| No. of Shares | | Amount | | No. of Shares | | Amount | | | | |
Balance at January 1, 2023 | 11,357 | | $ | — | | | 10,046,571 | | $ | 100 | | | $ | 451,607 | | | $ | (457,483) | | | $ | (83) | | | $ | (5,859) | |
Compensation expense for issuance of stock options | — | | — | | | — | | — | | | 1,661 | | | — | | | — | | | 1,661 | |
Private placement -issuance of common shares, net of expenses | — | | — | | | 19,646 | | 1 | | | 55 | | | — | | | — | | | 56 | |
Issuance of common stock with the employee stock purchase plan | — | | — | | | 15,417 | | — | | | 47 | | | — | | | — | | | 47 | |
Net loss | — | | $ | — | | | — | | $ | — | | | $ | — | | | $ | (9,000) | | | $ | — | | | $ | (9,000) | |
Foreign currency translation adjustments | — | | — | | | — | | — | | | — | | | — | | | 19 | | | 19 | |
Balance at March 31, 2023 | 11,357 | | $ | — | | | 10,081,634 | | $ | 101 | | | $ | 453,370 | | | $ | (466,483) | | | $ | (64) | | | $ | (13,076) | |
See accompanying Notes to Condensed Consolidated Financial Statements.
DELCATH SYSTEMS, INC.
Condensed Consolidated Statements of Cash Flows
(Unaudited)
(in thousands) | | | | | | | | | | | |
| Three months ended March 31, |
| 2024 | | 2023 |
Cash flows from operating activities: | | | |
Net loss | $ | (11,111) | | | $ | (9,000) | |
Adjustments to reconcile net loss to net cash used in operating activities: | | | |
Stock option compensation expense | 2,945 | | | 1,661 | |
Depreciation expense | 29 | | | 30 | |
Warrant liability fair value adjustment | 612 | | | — | |
Non-cash lease expense | 13 | | | 100 | |
Amortization of debt discount | 261 | | | 194 | |
Interest expense accrued related to convertible notes | 40 | | | 27 | |
Amortization of premiums and discounts on marketable securities | (229) | | | — | |
Changes in operating assets and liabilities: | | | |
Prepaid expenses and other assets | (174) | | | 14 | |
Accounts receivable | (1,323) | | | (92) | |
Inventory | (312) | | | (339) | |
Accounts payable and accrued expenses | (507) | | | 3,221 | |
Other liabilities, non-current | 172 | | | (80) | |
Deferred revenue | — | | | — | |
Net cash used in operating activities | (9,584) | | | (4,264) | |
Cash flows from investing activities: | | | |
Purchase of investment | (10,327) | | | — | |
Maturities of investments | 15,000 | | | — | |
Purchase of property, plant and equipment | (13) | | | — | |
Net cash provided by investing activities | 4,660 | | | — | |
Cash flows from financing activities: | | | |
Proceeds from private placement | 7,000 | | | 22,960 | |
Proceeds from the issuance of common stock relating to the employee stock purchase plan | 75 | | | 47 | |
Repayment of debt | (3,054) | | | (6,313) | |
Proceeds from exercise of warrants | — | | | — | |
Proceeds from exercise of stock options | — | | | — | |
Net cash provided by financing activities | 4,021 | | | 16,694 | |
Foreign currency effects on cash | 17 | | | 20 | |
Net (decrease) increase in total cash | (886) | | | 12,450 | |
Total Cash, Cash Equivalents and Restricted Cash: | | | |
Beginning of period | 12,696 | | | 11,822 | |
End of period | $ | 11,810 | | | $ | 24,272 | |
Cash, Cash Equivalents and Restricted Cash consisted of the following: | | | |
Cash and Cash Equivalents | $ | 11,760 | | | $ | 24,222 | |
Restricted Cash | 50 | | | 50 | |
Total | $ | 11,810 | | | $ | 24,272 | |
| | | | | | | | | | | |
| Three months ended March 31, |
| 2024 | | 2023 |
Supplemental Disclosure of Cash Flow Information: | | | |
Cash paid during the periods for: | | | |
Interest expense | $ | 250 | | | $ | 491 | |
Supplemental Disclosure of Non-Cash Investing and Financing Activities: | | | |
Right of use assets obtained in exchange for lease obligations | $ | 1,029 | | | $ | — | |
See accompanying Notes to Condensed Consolidated Financial Statements.
DELCATH SYSTEMS, INC.
Notes to the Condensed Consolidated Financial Statements
(amounts in thousands, except share and per share amounts)
(1) General
The unaudited interim condensed consolidated financial statements of Delcath Systems, Inc. (“Delcath” or the “Company”) as of and for the three months ended March 31, 2024 and 2023 should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 (the “Annual Report”), which was filed with the Securities and Exchange Commission (the “SEC”) on March 26, 2024 and may also be found on the Company’s website (www.delcath.com). In these notes to the interim condensed consolidated financial statements the terms “us”, “we” or “our” refer to Delcath and its consolidated subsidiaries.
Description of Business
The Company is an interventional oncology company focused on the treatment of primary and cancers metastatic to the liver. The Company’s lead product, the HEPZATOTM KIT (melphalan for Injection/Hepatic Delivery System), a drug/device combination product, was approved by the US Food and Drug Administration (the “FDA”) on August 14, 2023, indicated as a liver-directed treatment for adult patients with uveal melanoma with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection, or radiation. The first commercial use of HEPZATO KIT (“HEPZATO”) for the treatment of metastatic uveal melanoma (“mUM”) occurred in January 2024.
In the United States, HEPZATO is considered a combination drug and device product and is regulated as a drug by the FDA. Primary jurisdiction for regulation of HEPZATO has been assigned to the FDA’s Center for Drug Evaluation and Research. The FDA has granted Delcath six orphan drug designations (five for melphalan in the treatment of patients with ocular (uveal) melanoma, cutaneous melanoma, intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and neuroendocrine tumor indications and one for doxorubicin in the treatment of patients with hepatocellular carcinoma).
The Company has sufficient raw material and component constituent parts of HEPZATO KIT to meet the first year of its anticipated demand and it intends to manage supply chain risk through stockpiled inventory and contracting with multiple suppliers for critical components.
In Europe, the hepatic delivery system is a stand-alone medical device having the same device components as HEPZATO, but without the melphalan hydrochloride and is approved for sale under the trade name CHEMOSAT Hepatic Delivery System for Melphalan (“CHEMOSAT”), where it has been used at major medical centers to treat a wide range of cancers in the liver. On February 28, 2022, CHEMOSAT received Medical Device Regulation (MDR) certification under the European Medical Devices Regulation (EU) 2017/745, which may be considered by jurisdictions when evaluating reimbursement.
To support the New Drug Application for HEPZATO the Company conducted the FOCUS Clinical Trial for Patients with metastatic hepatic dominant Uveal Melanoma (the “FOCUS Trial”), a global registration clinical trial that investigated objective response rate in patients with mUM. The current focus of the Company’s clinical development program is to generate clinical data for CHEMOSAT and HEPZATO either as monotherapy or in combination with immunotherapy. The Company expects that this will support increased clinical adoption of and reimbursement for CHEMOSAT in Europe, and to support reimbursement in various jurisdictions, including the United States. In addition to HEPZATO’s use to treat mUM, the Company believes that HEPZATO has the potential to treat cancers in the liver, such as metastatic colorectal cancer, metastatic neuroendocrine tumors, metastatic breast cancer and intrahepatic cholangiocarcinoma, and plans to begin one or more studies of HEPZATO KIT to treat such conditions in 2024. The Company believes that those and similar disease states are areas of unmet medical needs that represent significant market opportunities.
Risks and Uncertainties
As detailed in the Company’s 2023 Annual Report filed on Form 10-K, the Company is subject to risks common to companies in the biopharmaceutical industry with FDA-approved products and planned clinical development activities, including, but not limited to, risks associated with successfully launching and commercializing the products; further developing HEPZATO to potentially treat other cancers in the liver and the Company’s ability to obtain any additional regulatory approval of such products in the United States and obtaining regulatory approval in other geographic markets; the uncertainty relating to the broad adoption of any approved products by physicians and consumers; and the impacts of significant competition.
In addition, high rates of inflation have resulted in the U.S. Federal Reserve raising interest rates. Increases in interest rates, especially if coupled with reduced government spending and volatility in financial markets, may further increase economic uncertainty and heighten these risks. Furthermore, if additional banks and financial institutions enter receivership or become insolvent in the future in response to financial conditions affecting the banking system and financial markets, the Company or its partners’ ability to access existing cash, cash equivalents and investments may be threatened and could have a material adverse effect on the Company’s business and financial condition, including the Company’s ability to access additional capital on favorable terms, or at all, which could in the future negatively affect the Company’s ability to pursue its business strategy.
Liquidity and Going Concern
On March 31, 2024, the Company had cash, cash equivalents and restricted cash totaling $11.8 million and short-term investments totaling $15.4 million, as compared to cash, cash equivalents and restricted cash totaling $12.7 million and short-term investments totaling $19.8 million at December 31, 2023. During the three months ended March 31, 2024, the Company used $9.6 million of cash in its operating activities and $3.1 million for principal payments.
The Company’s future results are subject to substantial risks and uncertainties. The Company has operated at a loss for its entire history and there can be no assurance that it will ever achieve or maintain profitability. The Company has historically funded its operations primarily with proceeds from sales of common stock, warrants and pre-funded warrants for the purchase of common stock, sales of preferred stock, proceeds from the issuance of convertible debt and borrowings under loan and security agreements.
If there is a substantial delay in the activation of sites to administer HEPZATO, the Company expects to need to raise additional capital under structures available to the Company, including debt and/or equity offerings, which may not be on favorable terms. In a substantially delayed site activation scenario, the Company would not have sufficient funds to meet its obligations within twelve months from the issuance date of these condensed consolidated financial statements. As such, there is uncertainty regarding the Company’s ability to maintain liquidity sufficient to operate its business effectively, which raises substantial doubt about the Company’s ability to continue as a going concern. Debt financing and equity financing, if available, may involve agreements that include covenants limiting or restricting the Company’s ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If the Company raises funds through collaborations or other similar arrangements with third parties, it may have to relinquish valuable rights to its technologies, future revenue streams, research programs for product candidates and/or grant licenses on terms that may not be favorable to the Company, any of which may reduce the value of its common stock. If the Company is unable to raise additional funds through equity or debt financings when needed, it may be required to delay, limit, reduce or terminate its product development or future commercialization efforts or grant rights to develop and market its product candidates to third parties even if the Company would otherwise prefer to develop and market such product candidates itself.
The Company also expects to use cash and cash equivalents to fund activities relating to commercial support for HEPZATO, CHEMOSAT and any future clinical research trials and operating activities. The Company’s future liquidity and capital requirements will depend on numerous factors, including the initiation and progress of clinical trials and research and product development programs; obtaining regulatory approvals and complying with applicable laws and regulations; the timing and effectiveness of product commercialization activities, including marketing arrangements; the timing and costs involved in preparing, filing, prosecuting, defending and enforcing intellectual property rights; the resolution of any disputes with third parties; and the effect of competing technological and market developments.
The Company’s capital commitments over the next twelve months include (a) $6.0 million to satisfy accounts payable, accrued expenses, current lease liabilities and current medac settlement and (b) $7.6 million of loan and convertible note principal payments, if the holders do not elect to convert up to $5.0 million of the notes into equity. Additional capital commitments beyond the next twelve months include (a) $1.0 million of lease liabilities; and (b) $0.8 million for settlement of litigation with medac.
Basis of Presentation
These interim condensed consolidated financial statements are unaudited and were prepared by the Company in accordance with generally accepted accounting principles in the United States of America (GAAP) and with the SEC’s instructions to Form 10-Q and Article 10 of Regulation S-X. They include the accounts of all wholly owned subsidiaries and all significant inter-company accounts and transactions have been eliminated in consolidation.
The preparation of interim condensed consolidated financial statements requires management to make assumptions and estimates that impact the amounts reported. These interim condensed consolidated financial statements reflect all adjustments, consisting of normal recurring accruals, necessary for a fair presentation of the Company’s results of operations, financial position and cash flows for the interim periods ended March 31, 2024 and 2023; however, certain information and footnote disclosures normally included in our audited consolidated financial statements which were included in our Annual Report have been condensed or omitted as permitted by GAAP. It is important to note that the Company’s results of operations and cash flows for interim periods are not necessarily indicative of the results of operations and cash flows to be expected for a full fiscal year or any interim period.
Significant Accounting Policies
There have been no material changes to our significant accounting policies as set forth in Note 3 Summary of Significant Accounting Policies to the consolidated financial statements included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023.
Recent Accounting Pronouncements
No new accounting standards were adopted during the three months ended March 31, 2024
(2) Revenue
The Company recognizes product revenue from sales of HEPZATO in the United States and CHEMOSAT in certain European countries in accordance with the five-step model in Accounting Standards Codification (“ASC”) 606, Revenue Recognition: (i) identify contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenues when (or as) the Company satisfies the performance obligation. Under this revenue standard, the Company recognizes revenue when its customer obtains control of the promised goods, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods. There are no contractual rights of returns, refunds or similar obligations.
HEPZATO
The Company ships and sells the HEPZATO directly to hospitals and treating centers based on approved agreements. Prior to use of the HEPZATO, the inventory is considered on consignment in which the Company retains title to the product. The Company recognizes HEPZATO revenue, based on contracted rates stated in an approved contract or purchase order, upon completion of the procedure as evidenced through the Company’s required Risk Evaluation and Mitigation Strategy (“REMS”) system. There is no obligation for the hospitals or treating centers to use the consigned HEPZATO, and the Company has no contractual right to receive payment until the product is used in a procedure and transfer of control is completed. See Note 5 for further information for consignment inventory.
CHEMOSAT
CHEMOSAT is sold directly to hospitals in the European Union and United Kingdom based on contracted rates in an approved contract or sales order. The Company recognizes product revenue from sales of CHEMOSAT upon shipment.
Revenue by product for the periods indicated were as follows:
| | | | | | | | | | | | | | |
| | Three Months Ended March 31, |
(In thousands) | | 2024 | | 2023 |
CHEMOSAT | | $ | 1,131 | | | $ | 597 | |
HEPZATO KIT | | 2,008 | | | — | |
Total revenue | | $ | 3,139 | | | $ | 597 | |
Concentration of Credit Risk
Potential credit risk exposure for both HEPZATO KIT and CHEMOSAT has been evaluated for the Company’s accounts receivable in accordance with ASC 326, Financial Instruments - Credit Losses. The loss percentage is calculated through
the use of current and historical economic and financial information. As of March 31, 2024, there were no estimated losses applied to the accounts receivables balance.
The Company’s total percentage of revenue and accounts receivable concentrations from a single customer consisted of the following:
| | | | | | | | | | | |
For the quarter ended and as of | Revenue | | Accounts Receivable |
March 31, 2024 | 52.4 | % | | 46.7 | % |
March 31, 2023 | 24.2 | % | | 21.8 | % |
(3) Cash, Cash Equivalents and Restricted Cash
Cash and cash equivalents that are restricted as to withdrawal or use under the terms of certain contractual agreements are recorded in Restricted Cash on the balance sheet. Restricted cash does not include required minimum balances.
Cash, cash equivalents, and restricted cash balances were as follows: | | | | | | | | | | | |
(In thousands) | March 31, 2024 | | December 31, 2023 |
Cash and cash equivalents | $ | 11,760 | | | $ | 12,646 | |
Security for credit cards | 50 | | | 50 | |
Total cash, cash equivalents and restricted cash shown in the statements of cash flows | $ | 11,810 | | | $ | 12,696 | |
(4) Investments
Marketable debt securities held by the Company are classified as available-for-sale pursuant to ASC 320, Investments - Debt and Equity Securities, and carried at fair value in the accompanying condensed consolidated balance sheets.
The following table summarizes the gross unrealized gains on the Company’s marketable securities as of March 31, 2024:
| | | | | | | | | | | | | | | | | | | | |
| | March 31, 2024 |
| | | | Gross Unrealized | | |
(In thousands) | | Amortized Cost | | Gains | | Estimated Fair Value |
U.S. government agency bonds | | $ | 15,195 | | | $ | 165 | | | $ | 15,360 | |
| | $ | 15,195 | | | $ | 165 | | | $ | 15,360 | |
Short-term investments | | | | | | $ | 15,360 | |
As of March 31, 2024, there was $0.2 million of interest receivable related to the outstanding debt securities held by the Company.
The following table summarizes the gross unrealized gains on the Company’s marketable securities as of December 31, 2023:
| | | | | | | | | | | | | | | | | | | | |
| | December 31, 2023 |
| | | | Gross Unrealized | | |
(in thousands) | | Amortized Cost | | Gains | | Estimated Fair Value |
U.S. government agency bonds | | $ | 19,651 | | | $ | 157 | | | $ | 19,808 | |
| | $ | 19,651 | | | $ | 157 | | | $ | 19,808 | |
Short-term investments | | | | | | $ | 19,808 | |
| | | | | | |
As of December 31, 2023, there was $0.2 million of interest receivable related to the outstanding debt securities held by the Company.
(5) Inventory
Inventory consists of the following: | | | | | | | | | | | |
(In thousands) | March 31, 2024 | | December 31, 2023 |
Raw materials | $ | 1,335 | | | $ | 1,443 | |
Work-in-process | 1,983 | | | 1,753 | |
Finished goods | 316 | | | 126 | |
Total inventory | $ | 3,634 | | | $ | 3,322 | |
The Company has consignment agreements with approved hospitals and treatment centers. As of March 31, 2024, there was $0.2 million in finished goods held at hospitals and treatment centers.
(6) Prepaid Expenses and Other Current Assets
Prepaid expenses and other current assets consist of the following: | | | | | | | | | | | |
(In thousands) | March 31, 2024 | | December 31, 2023 |
Clinical trial expenses | $ | 222 | | | $ | 222 | |
Insurance premiums | 173 | | | 157 | |
Professional services | 332 | | | 133 | |
Interest Receivable | 164 | | | 151 | |
Other | 387 | | | 428 | |
Total prepaid expenses and other current assets | $ | 1,278 | | | $ | 1,091 | |
(7) Property, Plant, and Equipment
Property, plant, and equipment consist of the following: | | | | | | | | | | | | | | | | | |
(In thousands) | March 31, 2024 | | December 31, 2023 | | Estimated Useful Life |
Buildings and land | $ | 1,318 | | | $ | 1,318 | | | 30 years - Buildings |
Enterprise hardware and software | 1,857 | | | 1,857 | | | 3 years |
Leaseholds | 1,779 | | | 1,787 | | | Lesser of lease term or estimated useful life |
Equipment | 1,262 | | | 1,263 | | | 7 years |
Furniture | 215 | | | 202 | | | 5 years |
Property, plant and equipment, gross | 6,431 | | | 6,427 | | | |
Accumulated depreciation | (5,095) | | | (5,075) | | | |
Property, plant and equipment, net | $ | 1,336 | | | $ | 1,352 | | | |
Depreciation expense for the three months ended March 31, 2024 and 2023 was less than $0.1 million for each period.
(8) Accrued Expenses
Accrued expenses consist of the following: | | | | | | | | | | | |
(In thousands) | March 31, 2024 | | December 31, 2023 |
Clinical expenses | $ | 1,064 | | | $ | 1,129 | |
Compensation, excluding taxes | 1,567 | | | 1,859 | |
Professional fees | 252 | | | 272 | |
Interest on convertible note | 753 | | | 713 | |
Inventory | 12 | | | 585 | |
Other | 747 | | | 691 | |
Total accrued expenses | $ | 4,395 | | | $ | 5,249 | |
(9) Leases
The Company recognizes right-of-use (“ROU”) assets and lease liabilities when it obtains the right to control an asset under a leasing arrangement with an initial term greater than twelve months. The Company leases its facilities under non-cancellable operating and financing leases. The Company evaluates the nature of each lease at the inception of an arrangement to determine whether it is an operating or financing lease and recognizes the ROU asset and lease liabilities based on the present value of future minimum lease payments over the expected lease term. The Company’s leases do not generally contain an implicit interest rate and therefore the Company uses the incremental borrowing rate it would expect to pay to borrow on a similar collateralized basis over a similar term in order to determine the present value of its lease payments.
For the three months ended March 31, 2024 and 2023, the Company recognized less than $0.1 million of operating lease expense in the U.S. and less than $0.1 million of operating lease expense in Ireland for the same periods.
In 2021, the Company entered into a sub-lease agreement (the “2021 Sub-Lease”) with its previous sub-lessee pursuant to which, effective August 2, 2021, the previous sub-lessee would become the lessee and the Company would then sublease its portion of the premises in Galway, Ireland from the previous sub-lessee. The Company’s annual rent expense under the 2021 Sub-Lease is less than $0.1 million for a term of 5 years.
In 2020, the Company entered into an amendment to a sub-lease agreement executed in 2016 for office space at 1633 Broadway, New York, New York. The term of the sub-lease agreement began in April 2016 and, pursuant to amendments, was extended through August 2023. As of August 31, 2023, the lease was month-to-month. No ROU assets or lease liabilities were recognized on the balance sheet as of December 31, 2023 for this arrangement. The Company ended the sublease for its former corporate offices at 1633 Broadway, New York, New York in February 2024.
On January 18, 2024, the Company entered into a lease agreement (the “Queensbury Lease”) to lease approximately 18,000 square feet of manufacturing and office space in Queensbury, New York (the “Premises”). The initial term of the lease is five years with a right to extend the lease by an additional five years, exercisable under certain conditions set forth in the Queensbury Lease. The Company’s annual rent expense under the Queensbury Lease is less than $0.2 million for a term of 5 years.
The following table summarizes the Company’s operating leases as of March 31, 2024: | | | | | | | | | | | | | | | | | |
(In thousands) | U.S. | | Ireland | | Total |
Operating cash flows for operating leases | $ | 4 | | | $ | 9 | | | $ | 13 | |
Weighted average remaining lease term | 9.8 | | 2.3 | | |
Weighted average discount rate - operating leases | 8 | % | | 8 | % | | |
Remaining maturities of the Company’s operating leases, excluding short-term leases, are as follows:
| | | | | | | | | | | | | | | | | |
(In thousands) | U.S. | | Ireland | | Total |
Year ended December 31, 2024 | $ | 108 | | | $ | 32 | | | $ | 140 | |
Year ended December 31, 2025 | 144 | | | 43 | | | 187 | |
Year ended December 31, 2026 | 144 | | | 25 | | | 169 | |
Year ended December 31, 2027 | 148 | | | — | | | 148 | |
Year ended December 31, 2028 | 153 | | | — | | | 153 | |
Thereafter | 800 | | | — | | | 800 | |
Total | 1,497 | | | 100 | | | 1,597 | |
Less present value discount | (471) | | | (8) | | | (479) | |
Operating lease liabilities included in the condensed consolidated balance sheets at March 31, 2024 | $ | 1,026 | | | $ | 92 | | | $ | 1,118 | |
(10) Loans and Convertible Notes Payable
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| March 31, 2024 | | December 31, 2023 |
(In thousands) | Gross | | Discount | | Net | | Gross | | Discount | | Net |
Loans payable, current1 | $ | 2,557 | | | $ | (149) | | | $ | 2,408 | | | $ | 5,610 | | | $ | (371) | | | $ | 5,239 | |
Convertible notes payable - current | 5,000 | | | (51) | | | 4,949 | | | 5,000 | | | (89) | | | 4,911 | |
Total - Loans and notes payable | $ | 7,557 | | | $ | (200) | | | $ | 7,357 | | | $ | 10,610 | | | $ | (460) | | | $ | 10,150 | |
1 The gross amount includes the 4.25% final payment of $0.5 million.
Term Loan from Avenue Venture Opportunities Fund, L.P.
On August 6, 2021, the Company entered into a Loan and Security Agreement (the “Avenue Loan Agreement”) with Avenue Venture Opportunities Fund, L.P. (the “Lender,” or “Avenue”) for a term loan in an aggregate principal amount of up to $20.0 million (the “Avenue Loan”). The Avenue Loan bears interest at an annual rate equal to the greater of (a) the sum of 7.70% plus the prime rate as reported in The Wall Street Journal and (b) 10.95%. The interest rate at March 31, 2024 was 16.20%. The Avenue Loan is secured by all of the Company’s assets globally, including intellectual property. The Avenue Loan matures on August 1, 2024.
The initial tranche of the Avenue Loan was $15.0 million, including $4.0 million that was funded into a restricted account. On March 15, 2023, the Company returned to Avenue $4.0 million held as restricted cash to pay down a portion of the outstanding loan balance, principal payments of $2.1 million and an incremental 4.25% of the final payment of $0.2 million. On March 31, 2023, the Avenue Loan Agreement was amended (the “Avenue Amendment”) to defer the interest only period to September 30, 2023, with an additional extension option upon FDA Approval for the HEPZATO KIT and subsequent receipt of at least $10 million from the sale and issuance of equity securities. On August 14, 2023, the Company received FDA approval and has subsequently received over $10 million from the exercise of Tranche A Preferred Warrants. At the Company’s option, it elected to extend the interest only period to December 31, 2023 and monthly principal payments of approximately $1.0 million began in January 2024.
Up to $3.0 million of the principal amount of the Avenue Loan outstanding may be converted, at Avenue’s option, into shares of the Company’s common stock at a conversion price of $11.98 per share.
The Avenue Loan Agreement requires the Company to make and maintain representations and warranties and other agreements that are customary in loan agreements of this type. The Avenue Loan Agreement also contains customary events of default, including non-payment of principal or interest, violations of covenants, bankruptcy and material judgements.
In connection with the initial entry into the Avenue Loan Agreement, the Company issued warrants to Avenue (the “Initial Avenue Warrant”) to purchase 127,755 shares of common stock at an exercise price per share equal to $0.01. Additionally, in connection with the Avenue Amendment, the Company issued to Avenue a warrant to purchase 34,072 shares of common stock at an exercise price per share equal to $0.01. Both the Initial Avenue Warrant and the warrant to purchase 34,072 shares of common stock were exercised in full in April 2024.
The Company determined that the embedded conversion option associated with the Avenue Loan did not require bifurcation and met the criteria for equity classification. In addition, the amendment was recorded under debt modification guidance. Aggregate debt discount amortization of $0.3 million and $0.2 million was recorded during the three months ended March 31, 2024 and 2023, respectively. Interest expense incurred was $0.3 million and $0.5 million for the three months ended March 31, 2024 and 2023, respectively.
Convertible Notes Payable
The Company has $2.0 million of principal outstanding related to Senior Secured Promissory Notes (the “Rosalind Notes”) which bear interest at 8% per annum. Pursuant to the original terms, the Rosalind Notes were convertible into Series E Preferred Stock at a price of $1,500 per share and were to mature on July 16, 2021.
On August 6, 2021, the Company executed an agreement to amend the Rosalind Notes to (i) reduce the conversion price to $1,198 per share of the Company’s Series E Preferred Stock; and (ii) extend the maturity date to October 30, 2024. In addition, the holders of the Rosalind Notes agreed to subordinate all of the Company’s indebtedness and obligations to Avenue and all of the holders’ security interest to the Avenue Loan and Avenue’s security interest in the Company’s property.
Interest expense accrued relating to the Rosalind Notes was less than $0.1 million for both the three months ended March 31, 2024 and 2023.
(11) Preferred Purchase Agreement
On March 27, 2023, we entered into a securities purchase agreement with certain accredited investors (the “Preferred Purchase Agreement”), pursuant to which on March 29, 2023, the Company issued and sold, in a private placement (the “Series F Preferred Offering”), (i) 24,900 shares of Series F-1 Convertible Preferred Stock, par value $0.01 per share (the “Series F-1 Preferred Stock”), (ii) tranche A warrants (the “Preferred Tranche A Warrants”) to acquire 34,859 shares of Series F-3 Convertible Preferred Stock, par value $0.01 per share (the “Series F-3 Preferred Stock”) and (iii) tranche B warrants (the “Preferred Tranche B Warrants”, together with the Preferred Tranche A Warrant, the “Preferred Warrants”) to acquire 24,900 shares of Series F-4 Convertible Preferred Stock, par value $0.01 per share (the “Series F-4 Preferred Stock”) for an aggregate offering price of $24.9 million before deducting the fees paid to the placement agent and the financial advisors and other financing expenses payable by the Company.
The gross proceeds of $24.9 million from the Series F Preferred Offering have been allocated first to the Preferred Warrant liabilities at their fair value of $4.9 million, with the residual of $20.0 million being allocated to the Series F-1 Preferred Stock.
As of March 31, 2024, all of the Preferred Tranche A Warrants were exercised for an aggregate exercise price of $34.9 million. The Preferred Tranche B Warrants are exercisable for 24,900 shares of Series F-4 Preferred Stock, with an aggregate exercise price of $24.9 million until the earlier of (i) 21 days following the Company’s announcement of receipt of at least $10 million in quarterly U.S. revenue from the commercialization of HEPZATO and (ii) March 31, 2026.
Pursuant to the Certificate of Designation of Preferences, Rights and Limitations of the Series F Convertible Voting Preferred Stock (the “Certificate of Designation”), each share of Series F-1 Preferred Stock automatically converted into shares of common stock and/or, if applicable (in accordance with the beneficial ownership limitations then in effect), shares of Series F-2 Preferred Stock, par value $0.01 per share (the “Series F-2 Preferred Stock” and, together with the Series F-1 Preferred Stock, the Series F-3 Preferred Stock and the Series F-4 Preferred Stock, the “Series F Preferred Stock”) in lieu of common stock. Subject to limitations set forth in the Certificate of Designation, the shares of Series F-2, F-3 and F-4 Preferred Stock are convertible into common stock at the option of the holder at the conversion price of $3.30 per share, $4.50 per share and $6.00 per share, respectively, rounded down to the nearest whole share, and in each case subject to the terms and limitations contained in the Certificate of Designation.
As of March 31, 2024, 54,207 shares of the Company’s Series F-1, F-2 and F-3 Preferred Stock were converted into 13,853,143 shares of common stock. As of March 31, 2024, there were 2,542 shares of Series F-2 Preferred Stock, 3,010 shares of Series F-3 Preferred Stock and no shares of Series F-4 Preferred Stock outstanding.
The Series F-2, F-3 and F-4 Preferred Stock are not mandatorily redeemable, redeemable at the holder’s election or contingently redeemable at the holder’s election (at this point, a Deemed Liquidation Event would potentially trigger pro
rata liquidation payments to the preferred and common stockholders on a pro rata “as converted” basis). Accordingly, the Series F-2, F-3 and F-4 Preferred are now classified as permanent equity.
The Company determined that the outstanding Preferred Warrants should be liability-classified. See Note 16 for a discussion of the accounting treatment of the Common Warrants and Preferred Warrants.
(12) Stockholders’ Equity
Public and Private Placements
Common Purchase Agreement
On March 27, 2023, the Company entered into a securities purchase agreement (the “Common Purchase Agreement”) with the Company’s Chief Executive Officer, Gerard Michel, pursuant to which the Company agreed to issue and sell, in a private placement (the “Common Offering”) shares of common stock, tranche A warrants (“Common Tranche A Warrants”) to acquire 31,110 shares of common stock, tranche B warrants (“Common Tranche B Warrants”, together with the Common Tranche A Warrants, the “Common Warrants”) to acquire 16,666 shares of common stock. On March 29, 2023, the Company closed the Common Offering.
The aggregate exercise price of the Common Tranche A Warrants issued pursuant to the Common Offering is approximately $0.1 million.
On August 14, 2023, the Company announced the receipt of the FDA Approval and all Common Tranche A Warrants were exercised and converted into 31,110 shares of common stock.
The aggregate exercise price of the Common Tranche B Warrants issued in the Common Offering is approximately $0.1 million. The Common Tranche B Warrants are exercisable for an aggregate of 16,666 shares of common stock until the earlier of 21 days following the Company’s announcement of receipt of recording at least $10 million in quarterly U.S. revenue from the commercialization of HEPZATO and March 31, 2026.
Securities Purchase Agreement
On March 14, 2024, the Company and certain accredited investors (each an “Investor” and collectively, the “Investors”) entered into a securities purchase agreement (the “Securities Purchase Agreement”) pursuant to which the Company agreed to sell and issue to the Investors in a private placement (the “Private Placement”) (i) an aggregate of 876,627 shares of the Company’s common stock, par value $0.01 per share, at a purchase price of $3.72 per share, and (ii) to certain investors, in lieu of shares of common stock, 1,008,102 pre-funded warrants (the “Pre-Funded Warrants”) at a price per Pre-Funded Warrant of $3.71 (the “Warrant Shares” and together with the Shares, the “Securities”). The Pre-Funded Warrants will have an exercise price of $0.01 per share of common stock, be immediately exercisable and remain exercisable until exercised in full.
The Private Placement closed on March 19, 2024. The Company received gross proceeds of approximately $7.0 million, before deducting offering expenses payable by the Company.
Registration Rights for Preferred and Common Offerings
Pursuant to the Preferred Purchase Agreement and the Common Purchase Agreement (collectively, the “Purchase Agreements”), the Company filed a registration statement on Form S-3 (the “June 2023 Resale Registration Statement”) providing for the resale by the investors party thereto of the common stock issuable upon conversion of the Registrable Shares (as defined in the Purchase Agreements). The June 2023 Resale Registration Statement became effective on June 28, 2023.
Pursuant to the Securities Purchase Agreement, the Company filed a registration statement on Form S-3 (the “April 2024 Resale Registration Statement”) providing for the resale of the common stock and common stock issuable upon the exercise of the Pre-Funded Warrants. The April 2024 Resale Registration Statement also provided for the common stock issued upon the exercise of pre-funded warrants to purchase common stock issued by the Company pursuant to the Avenue Amendment. The registration became effective on May 9, 2024.
There is no established public trading market for the Series F Preferred Stock, the Preferred Warrants, Common Warrants or the Pre-Funded Warrants and the Company does not intend to list such securities on any national securities exchange or nationally recognized trading system.
At-the-Market Offering
The Company has entered into a Controlled Equity OfferingSM Sales Agreement (“ATM Sales Agreement”), with Cantor Fitzgerald & Co. (the “Sales Agent”), pursuant to which the Company may offer and sell, at its sole discretion through the Sales Agent, shares of common stock having an aggregate offering price of up to $17.0 million. To date, the Company has sold approximately $4.0 million of its common stock, prior to issuance costs, under the ATM Sales Agreement. No sales were made during the three months ended March 31, 2024.
Authorized Shares
The Company is authorized to issue 80 million shares of common stock, $0.01 par value, and 10 million shares of preferred stock, $0.01 par value. As of March 31, 2024, the Company has designated the following preferred stock:
| | | | | | | | |
Designated Preferred Shares | | March 31, 2024 |
Series A | | 4,200 | |
Series B | | 2,360 | |
Series C | | 590 | |
Series D | | 10,000 | |
Series E | | 40,000 | |
Series E-1 | | 12,960 | |
Series F-1 | | 24,900 | |
Series F-2 | | 24,900 | |
Series F-3 | | 34,860 | |
Series F-4 | | 24,900 | |
Total | | 179,670 | |
Preferred Stock
As of March 31, 2024, there were an aggregate of 11,257 shares of Series E and Series E-1, 2,542 Series F-2 and 3,010 Series F-3 Convertible Preferred Stock outstanding, respectively.
Omnibus Equity Incentive Plan
On September 30, 2020, the Company’s 2020 Omnibus Equity Incentive Plan (the “2020 Plan”) was adopted by the Company’s Board of Directors. On November 23, 2020, the Company’s stockholders approved the 2020 Plan. The 2020 Plan will continue in effect until the tenth anniversary of the date of its adoption by the Board or until earlier terminated by the Board. The 2020 Plan is administered by the Board of Directors or a committee designated by the Board of Directors. The 2020 Plan provides for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock awards, restricted stock unit awards, performance awards, as well as other stock-based awards or cash awards that are deemed to be consistent with the purposes of the plan to Company employees, directors and consultants. As of March 31, 2024, there have been 5,125,000 shares of common stock reserved under the 2020 Plan, of which 232,566 remained available to be issued.
In addition to options granted from the 2020 Plan, the Company also grants employment inducement awards pursuant to Listing Rule 5635(c)(4) of the corporate governance rules of the NASDAQ Stock Market. The inducement grants are intended to provide incentive to certain individuals to enter into employment with the Company. Prior to December 5, 2023, the inducement awards were granted outside of the 2020 Plan, however they are governed in all respects as if they were issued under the 2020 Plan. These grants do not reduce the number of options available for issuance under the 2020 Plan.
On December 5, 2023, the Company’s 2023 Inducement Plan (the “2023 Plan”) was adopted by the Company’s Board of Directors. The 2023 Plan is administered by a Compensation Committee of two or more Independent Directors appointed by the Board of Directors and is intended to provide for the grant of non-qualified stock options, stock appreciation rights, restricted stock awards, restricted stock unit awards, performance awards, as well as other stock-based awards or cash awards that are deemed appropriate to incentivize employment with the Company. Awards from the 2023 Plan can only be granted to individuals who have not previously worked for the Company or have not worked for the Company for a bona fide period of time. As of March 31, 2024, there have been 650,000 shares of common stock reserved under the 2023 Plan, of which 372,000 remain available to be granted.
Stock Options
The following tables include information for all options granted including inducement grants that are granted outside of the 2020 Plan.
The Company values stock options using the Black-Scholes option pricing model and used the following assumptions, on a weighted-average basis, during the reporting periods: | | | | | | | | | | | |
| Three Months Ended March 31, |
| 2024 | | 2023 |
Expected terms (years) | 5.6 | | 5.8 |
Expected volatility | 115.0% | | 172.8% |
Risk-free interest rate | 4.19% | | 4.08% |
Expected dividends | 0.00% | | 0.00% |
The following is a summary of stock option activity for the three months ended March 31, 2024:
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| Number of Options | | Weighted Average Exercise Price Per Share | | Weighted Average Grant Date Fair Value Per Share | | Weighted Average Remaining Contractual Term (in years) | | Aggregate Intrinsic Value (in thousands) |
Outstanding at January 1, 2024 | 4,183,232 | | $ | 8.17 | | | $ | 7.60 | | | 8.3 | | $ | 147 | |
Granted | 2,017,596 | | 4.80 | | | 3.92 | | 9.7 | | |
Exercised | — | | | — | | | — | | | | | — | |
Expired | (15,341) | | 7.16 | | | 6.91 | | | | |
Cancelled/Forfeited | (146,312) | | 6.08 | | | 5.75 | | | | |
Outstanding at March 31, 2024 | 6,039,175 | | $ | 7.10 | | | $ | 6.42 | | | 8.6 | | $ | 433 | |
| | | | | | | | | |
Exercisable at March 31, 2024 | 2,569,497 | | $ | 9.47 | | | $ | 8.73 | | | 7.4 | | $ | 74 | |
Unvested at March 31, 2024 | 3,469,678 | | | $ | 5.34 | | | $ | 4.70 | | | 9.4 | | $ | 358 | |
The following table summarizes information for stock option shares outstanding and exercisable at March 31, 2024: | | | | | | | | | | | | | | | | | | | | |
| | | | Options Outstanding |
Range of Exercise Prices | | Outstanding Number of Options | | Weighted Average Remaining Option Term (in years) | | Number of Options |
$2.83 - $51.50 | | 6,038,676 | | 8.6 | | 6,038,676 |
$51.50+ | | 499 | | 4.8 | | 499 |
| | 6,039,175 | | 8.6 | | 6,039,175 |
The following is a summary of share-based compensation expense in the statement of operations for the three months ended March 31, 2024: | | | | | | | | | | | | | | | |
| Three Months Ended March 31, | | |
(In thousands) | 2024 | | 2023 | | | | |
Selling, general and administrative | $ | 2,042 | | | $ | 1,118 | | | | | |
Research and development | 647 | | | 417 | | | | | |
Cost of goods sold | 256 | | | 126 | | | | | |
Total | $ | 2,945 | | | $ | 1,661 | | | | | |
At March 31, 2024, there was $10.3 million of aggregate unrecognized compensation expense related employee and board stock option grants. The cost is expected to be recognized over a weighted average period of 1.2 years.
Common Stock Warrants
The following is a summary of common stock warrant activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | |
| Warrants | | Weighted Average Exercise Price | | Weighted Average Remaining Life (in years) |
Outstanding at January 1, 2024 | 4,665,201 | | $ | 7.76 | | | 1.6 |
Warrants issued | 1,008,102 | | 0.01 | | | 5.0 |
Warrants exercised | — | | | — | | | |
Outstanding at March 31, 2024 | 5,673,303 | | | | 2.0 |
Exercisable at March 31, 2024 | 5,673,303 | | $ | 6.39 | | | 2.0 |
The following table presents information related to common stock warrants outstanding at March 31, 2024: | | | | | | | | | | | | | | | | | |
| | | Warrants Exercisable |
Range of Exercise Prices | Outstanding Number of Warrants | | Weighted Average Remaining Warrant Term (in years) | | Number of Warrants |
$0.01 | 2,045,894 | | 4.0 | | 2,045,894 |
$6.00 | 16,666 | | 2.0 | | 16,666 |
$10.00 | 3,610,743 | | 1.0 | | 3,610,743 |
| 5,673,303 | | 2.0 | | 5,673,303 |
As of March 31, 2024, there were no warrants exercised for common shares.
Preferred Stock Warrants
The following is a summary of preferred stock warrant activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | |
| Warrants | | Weighted Average Exercise Price | | Weighted Average Remaining Life (in years) |
Outstanding at January 1, 2024 | 24,900 | | | $ | 1,000 | | | 2.3 |
Warrants issued | — | | | | | |
Warrants exercised | — | | | | | |
Outstanding at March 31, 2024 | 24,900 | | $ | 1,000 | | | 2.0 |
Exercisable at March 31, 2024 | 24,900 | | $ | 1,000 | | | 2.0 |
Employee Stock Purchase Plan
In August 2021, the Company’s Board of Directors, with shareholder approval in May 2022, adopted the Employee Stock Purchase Plan (the “ESPP”). The ESPP provides for a maximum of 260,295 shares of common stock to be purchased by participating employees of which 62,575 have been issued as of March 31, 2024 since the inception of the benefit in 2021. Employees who elect to participate in the ESPP will be able to purchase common stock at the lower of 85% of the fair market value of common stock on the first or last day of the applicable six-month offering period.
(13) Net Loss per Share
Basic net loss per share is determined by dividing net loss by the weighted average shares of common stock outstanding during the period, without consideration of potentially dilutive securities, except for those shares that are issuable for little or no cash consideration. Diluted net loss per share is determined by dividing net loss by diluted weighted average shares outstanding. Diluted weighted average shares reflects the dilutive effect, if any, of potentially dilutive common shares, such as stock options and warrants calculated using the treasury stock method. In periods with reported net operating losses, all common stock options, convertible preferred shares, and preferred and common warrants are generally deemed anti-dilutive such that basic net loss per share and diluted net loss per share are equal.
The following potentially dilutive securities were excluded from the computation of earnings per share as of March 31, 2024 and 2023 because their effects would be anti-dilutive: | | | | | | | | | | | |
| March 31, |
| 2024 | | 2023 |
Common stock warrants | 3,627,409 | | 3,658,520 |
Assumed conversion of preferred stock warrants | 4,149,994 | | 11,896,667 |
Assumed conversion of preferred stock | 2,564,911 | | 8,681,176 |
Assumed conversion of convertible notes | 488,031 | | 488,031 |
Stock options | 6,039,175 | | 2,894,393 |
Total | 16,869,520 | | 27,618,787 |
As of March 31, 2024 and 2023, the Company had 2,045,894 and 1,576,620 pre-funded warrants outstanding, respectively. The following table provides a reconciliation of the weighted average shares outstanding calculation for the three months ended March 31, 2024 and 2023: | | | | | | | | | | | | | | | |
| Three months ended March 31, | | |
| 2024 | | 2023 | | | | |
Weighted average shares issued | 23,705,374 | | 10,081,634 | | | | |
Weighted average pre-funded warrants | 1,181,806 | | 1,540,750 | | | | |
Weighted average shares outstanding | 24,887,180 | | 11,622,384 | | | | |
(14) Income Taxes
As discussed in “Note 17—Income Taxes” to the notes to the consolidated financial statements contained in the Annual Report, the Company has a valuation allowance against the full amount of its net deferred tax assets. The Company currently provides a valuation allowance against deferred tax assets when it is more likely than not that some portion or all of its deferred tax assets will not be realized. The Company has not recognized any unrecognized tax benefits in its balance sheet.
The Company is subject to income tax in the U.S., as well as various state and international jurisdictions. The federal and state tax authorities can generally reduce a net operating loss (but not create taxable income) for a period outside the statute of limitations in order to determine the correct amount of net operating loss which may be allowed as a deduction against income for a period within the statute of limitations. Additional information regarding the statutes of limitations can be found in Note 17 - Income Taxes of the Company’s Annual Report.
The Inflation Reduction Act of 2022 included tax legislation that became effective in the first quarter of 2023. Significant legislation for corporate taxpayers includes a corporate alternative minimum tax of 15% for companies with $1 billion or more in average net financial statement profits over the three previous years, as well as a 1% indirect excise tax on the repurchase of shares by a publicly traded company. The Company does not expect this legislation to have an effect on the
tax provision as of March 31, 2024, however the Company will continue to evaluate the effect on the tax provision each reporting period.
(15) Commitments and Contingencies
medac Matter
In April 2021, the Company’s wholly owned subsidiary, Delcath Systems Ltd, issued to medac GmbH, a privately held, multi-national pharmaceutical company based in Germany (“medac”), an invoice for a €1 million milestone payment under a License, Supply and Marketing Agreement dated December 10, 2018 (the “medac Agreement”) between medac and the Company. The medac Agreement provided to medac the exclusive right to market and sell CHEMOSAT in certain designated countries for which the Company was entitled to a combination of upfront and success-based milestone payments as well as a fixed transfer price per unit of CHEMOSAT and specified royalties.
In response to medac’s subsequent dispute and non-payment of the invoice, on October 12, 2021, the Company notified medac in writing that it was terminating the medac Agreement due to medac’s nonpayment of the €1 million milestone payment, with the effective date of termination of the medac Agreement being April 12, 2022. On December 16, 2021, the Company initiated an arbitration proceeding pursuant to the dispute resolution procedures of the medac Agreement for the non-payment of the invoice.
On December 30, 2022, the parties reached a final settlement of the matter and the Company agreed to pay medac either (a) a royalty on sales of CHEMOSAT units over a defined minimum for a period of five years or until a maximum payment has been reached, or (b) a minimum annual payment of $0.2 million in the event the annual royalty payment does not reach the agreed minimum payment amount. The Company has estimated the fair value of the settlement to be $1.0 million as of March 31, 2024 and recorded $0.8 million as other liabilities, non-current and $0.2 million as accrued expenses on the Company’s condensed consolidated balance sheet as of March 31, 2024.
Manufacturing and Supply Agreements
The Company has a License, Supply and Contract Manufacturing Agreement (the “Supply Agreement”) for the supply of melphalan provided in the HEPZATO KIT. An amendment to the Supply Agreement was entered into on April 22, 2024, and effective as of May 1, 2024, which extends the term of the agreement through December 31, 2028, with an option to renew for successive five-year periods upon the mutual written consent of both parties. Although the Supply Agreement does not contain an annual minimum purchase quantity, the Agreement requires Delcath to order full lots of labeled melphalan vials. As of March 31, 2024, the Company has committed to purchasing $2.25 million of melphalan under this Supply Agreement in 2024.
(16) Fair Value Measurements
The table below presents activity within Level 3 of the fair value hierarchy, our liabilities carried at fair value for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | |
| Level 3 |
(In thousands) | Contingent liabilities | | Warrants | | Total |
Balance at January 1, 2024 | $ | 996 | | | $ | 5,548 | | | $ | 6,544 | |
Total change in foreign exchange | (22) | | | — | | | (22) | |
Warrant liability fair value adjustment | — | | | 612 | | | 612 | |
Change due to warrant exercise | $ | — | | | $ | — | | | $ | — | |
Balance at March 31, 2024 | $ | 974 | | | $ | 6,160 | | | $ | 7,134 | |
Contingent liabilities are re-measured to fair value each reporting period using projected financial targets, discount rates, probabilities of payment, and projected payment dates. Projected contingent payment amounts are discounted back to the current period using a discounted cash flow model. Projected financial targets are based on our most recent internal operational budgets and may take into consideration alternate scenarios that could result in more or less profitability for the respective service line. Increases or decreases in projected financial targets and probabilities of payment may result in significant changes in the fair value measurements. Increases in discount rates and the time to payment may result in lower fair value measurements. Increases or decreases in any of those inputs in isolation may result in a significantly lower or higher fair value measurement.
As disclosed in Note 11 and Note 12 of the Company’s consolidated financial statements, the Company allocated part of the proceeds of the Series F Preferred Offering to warrant liability issued in connection with the transaction. The valuations of the warrants were determined using option pricing models. The Company concluded that the Preferred Warrants were not in the scope of Accounting Standards Codification, Distinguishing Liabilities from Equity (ASC 480) since the Preferred Warrants are not mandatorily redeemable; and do not have obligations to issue a variable number of shares of preferred stock. The Company determined the Preferred Warrants met the definition of a derivative in accordance with ASC 815 but were not considered indexed to the Company’s common stock since the warrants require early settlement by repurchasing the preferred warrants for cash in an amount equal to the Black-Scholes value in the event of a Fundamental Transaction at pre-specified volatility of 100% as an input to the Black-Scholes calculation. The Company determined to record the Preferred Warrants at fair value with subsequent changes in fair value recorded in earnings at the end of each reporting period. For the three months ended March 31, 2024, the Company recorded an increase to other expense of $0.6 million related to the change in fair value of the warrant liability. These models use inputs such as the underlying price of the shares issued at the measurement date, volatility, risk free interest rate and expected life of the instrument. The Company has classified the warrants as a long-term liability due to potential provisions relating to the holders’ ability to exercise the warrants beyond twelve months of the reporting date.
The fair value of the preferred and common warrants at March 31, 2024 and December 31, 2023 was determined by using option pricing models assuming the following: | | | | | | | | | | | |
| March 31, 2024 | | December 31, 2023 |
Risk free interest rate | 4.49% | | 4.09% |
Expected term (years) | 2.0 | | 2.3 |
Expected volatility | 65% | | 70% |
Expected dividends | 0.00% | | 0.00% |
Additionally, the Company has determined that the warrant liability should be classified within Level 3 of the fair-value hierarchy by evaluating each input for the option pricing models against the fair-value hierarchy criteria and using the lowest level of input as the basis for the fair-value classification as called for in ASC 820. There are six inputs: closing price of the Company’s stock on the day of evaluation; the exercise price of the warrants; the remaining term of the warrants; the volatility of the Company’s stock over that term; annual rate of dividends; and the risk-free rate of return. Of those inputs, the exercise price of the warrants and the remaining term are readily observable in the warrant agreements. The annual rate of dividends is based on the Company’s historical practice of not granting dividends. The closing price of the Company’s stock would fall under Level 1 of the fair-value hierarchy as it is a quoted price in an active market, the risk-free rate of return is a Level 2 input, while the historical volatility is a Level 3 input as defined in ASC 820-10. Since the lowest level input is a Level 3, the Company determined the warrant liability is most appropriately classified within Level 3 of the fair value hierarchy.
The following tables present information about the Company’s financial assets and liabilities that have been measured at fair value as of March 31, 2024 and December 31, 2023 and indicate the fair value hierarchy of the valuation inputs utilized to determine such fair value.
| | | | | | | | | | | | | | | | | | | | | | | | | | |
| | March 31, 2024 |
(In thousands) | | Quoted Prices in Active Markets (Level 1) | | Significant Other Observable Inputs (Level 2) | | Significant Unobservable Inputs (Level 3) | | Total |
Assets: | | | | | | | | |
Money market funds | | $ | 72 | | | $ | — | | | $ | — | | | $ | 72 | |
U.S. government agency bonds | | — | | | 15,360 | | | — | | | 15,360 | |
Total Assets | | $ | 72 | | | $ | 15,360 | | | $ | — | | | $ | 15,432 | |
| | | | | | | | |
Liabilities: | | | | | | | | |
Contingent Liability | | $ | — | | | $ | — | | | $ | 974 | | | $ | 974 | |
Warrant Liabilities | | — | | | — | | | 6,160 | | | 6,160 | |
Total Liabilities | | $ | — | | | $ | — | | | $ | 7,134 | | | $ | 7,134 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | |
| | December 31, 2023 |
(In thousands) | | Quoted Prices in Active Markets (Level 1) | | Significant Other Observable Inputs (Level 2) | | Significant Unobservable Inputs (Level 3) | | Total |
Assets: | | | | | | | | |
Money market funds | | $ | 392 | | | $ | — | | | $ | — | | | $ | 392 | |
U.S. government agency bonds | | — | | | 19,808 | | | — | | | 19,808 | |
Total Assets | | $ | 392 | | | $ | 19,808 | | | $ | — | | | $ | 20,200 | |
| | | | | | | | |
Liabilities: | | | | | | | | |
Contingent Liability | | $ | — | | | $ | — | | | $ | 996 | | | $ | 996 | |
Warrant Liabilities | | — | | | — | | | 5,548 | | | 5,548 | |
Total Liabilities | | $ | — | | | $ | — | | | $ | 6,544 | | | $ | 6,544 | |
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations
The following discussion and analysis of the financial condition and results of operations of Delcath Systems, Inc. (“Delcath” or the “Company”) should be read in conjunction with the unaudited interim condensed consolidated financial statements and notes thereto contained in Item 1 of Part I of this Quarterly Report on Form 10-Q and the audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 (the “Annual Report”), which was filed with the Securities and Exchange Commission (the “SEC”) on March 26, 2024, to provide an understanding of its results of operations, financial condition and cash flows.
All references in this Quarterly Report on Form 10-Q to “we,” “our,” “us” and the “Company” refer to Delcath Systems, Inc., and its subsidiaries unless the context indicates otherwise.
This Quarterly Report on Form 10-Q and may include trademarks, service marks and trade names owned or licensed by us, including CHEMOFUSE, CHEMOSAT, CHEMOSATURATION, DELCATH, HEPZATO, HEPZATO KIT, PHP and THE DELCATH PHP SYSTEM. Solely for convenience and readability, trademarks, service marks and trade names, including logos, artwork and other visual displays, may appear in a non-traditional trademark usage manner, including without the ® or TM symbols, but such references are not intended to indicate, in any way, that we will not assert, to the fullest extent under applicable law, our rights or the rights of the applicable licensor to these trademarks, service marks and trade names. All trademarks, service marks and trade names included in this Quarterly Report on Form 10-Q are the property of the Company or the Company’s licensor, as applicable.
Disclosure Regarding Forward-Looking Statements
This Quarterly Report on Form 10-Q contains certain “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 with respect to our business, financial condition, liquidity, and results of operations. Words such as “anticipates,” “expects,” “intends,” “plans,” “predicts,” “believes,” “seeks,” “estimates,” “could,” “would,” “will,” “may,” “can,” “continue,” “potential,” “should,” and the negative of these terms or other comparable terminology often identify forward-looking statements. Statements in this Quarterly Report on Form 10-Q that are not historical facts are hereby identified as “forward-looking statements” for the purpose of the safe harbor provided by Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and Section 27A of the Securities Act of 1933, as amended (the “Securities Act”). These forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results to differ materially from the results contemplated by the forward-looking statements, including the risks discussed in Item 3 “Quantitative and Qualitative Disclosures About Market Risk,” and the risks discussed in Part II, Item 1A under “Risk Factors” and the risks detailed from time to time in our future reports filed with the SEC. These forward-looking statements include, but are not limited to, statements about:
•our estimates regarding sufficiency of our cash resources, anticipated capital requirements, future revenue and our need for additional financing;
•the commencement of future clinical trials, if any, and the results and timing of those clinical trials;
•our ability to successfully commercialize CHEMOSAT, HEPZATO, and future products, if any, generate revenue and successfully obtain reimbursement for the products and/or the associated procedures;
•our sales, marketing and distribution capabilities and strategies, including for the commercialization and manufacturing of CHEMOSAT, HEPZATO, and future products, if any;
•the rate and degree of market acceptance and clinical utility of CHEMOSAT, HEPZATO, and future products, if any;
•developments relating to our competitors and our industry;
•the initiation and success of our research and development programs;
•submission and timing of applications for regulatory approval and approval thereof;
•our ability to successfully source components of CHEMOSAT, HEPZATO, and future products, if any, and enter into supplier contracts;
•our ability to source melphalan and other critical components necessary to manufacture HEPZATO;
•our ability to successfully manufacture CHEMOSAT and HEPZATO;
•our ability to successfully negotiate and enter into agreements with distribution, strategic and corporate partners; and
•our estimates of potential market opportunities and our ability to successfully realize these opportunities.
Many of the important factors that will determine these results are beyond our ability to control or predict. You are cautioned not to put undue reliance on any forward-looking statements, which speak only as of the date of this Quarterly Report on Form 10-Q. Except as otherwise required by law, we do not assume any obligation to publicly update or release any revisions to these forward-looking statements to reflect events or circumstances after the date of this Quarterly Report on Form 10-Q or to reflect the occurrence of unanticipated events.
Company Overview
We are an interventional oncology company focused on the treatment of primary cancers metastatic to the liver. Our lead product, the HEPZATO KIT (melphalan for Injection/Hepatic Delivery System), a drug/device combination product, was approved by the US Food and Drug Administration (the “FDA”) on August 14, 2023, indicated as a liver-directed treatment for adult patients with uveal melanoma with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection, or radiation. The first commercial use of HEPZATO for the treatment of metastatic hepatic dominant uveal melanoma (“mUM”) took place in January 2024.
In the United States, HEPZATO is considered a combination drug and device product and is regulated as a drug by the FDA. Primary jurisdiction for regulation of HEPZATO has been assigned to the FDA’s Center for Drug Evaluation and Research. The FDA has granted us six orphan drug designations (five for melphalan in the treatment of patients with ocular (uveal) melanoma, cutaneous melanoma, intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and neuroendocrine tumor indications and one for doxorubicin in the treatment of patients with hepatocellular carcinoma).
We have sufficient raw material and component constituent parts of HEPZATO KIT to meet the first year of our anticipated demand and we intend to manage supply chain risk through stockpiled inventory and contracting with multiple suppliers for critical components.
In Europe, the hepatic delivery system is a stand-alone medical device having the same device components as HEPZATO, but without the melphalan hydrochloride and is approved for sale under the trade name CHEMOSAT Hepatic Delivery System for Melphalan, or CHEMOSAT, where it has been used at major medical centers to treat a wide range of cancers in the liver. On February 28, 2022, CHEMOSAT received Medical Device Regulation (MDR) certification under the European Medical Devices Regulation (EU)2017/745, which may be considered by jurisdictions when evaluating reimbursement. As of March 1, 2022, we have assumed direct responsibility for sales, marketing and distribution of CHEMOSAT in Europe.
Our clinical development program for HEPZATO was comprised of the FOCUS Clinical Trial for Patients with metastatic hepatic dominant Uveal Melanoma (the “FOCUS Trial”), a global registration clinical trial that investigated objective response rate in patients with mUM. The current focus of our clinical development program is to generate clinical data for CHEMOSAT and HEPZATO in patients with mUM, either as monotherapy or in combination with immunotherapy. We expect that this will support increased clinical adoption of and reimbursement for CHEMOSAT in Europe, and to support reimbursement in various jurisdictions, including the United States. In addition to HEPZATO’s use to treat mUM, the Company believes that HEPZATO has the potential to treat cancers in the liver, such as metastatic colorectal cancer, metastatic neuroendocrine tumors, metastatic breast cancer and intrahepatic cholangiocarcinoma, and plans to begin one or more studies of HEPZATO KIT to treat such conditions in 2024. We believe that those and similar disease states are areas of unmet medical needs that represent significant market opportunities.
Results of Operations | | | | | | | | | | | |
| Three months ended March 31, |
(In thousands) | 2024 | | 2023 |
Total revenues | $ | 3,139 | | | $ | 597 | |
Cost of goods sold | (903) | | | (181) | |
Gross profit | 2,236 | | | 416 | |
Research and development expenses | 3,700 | | | 4,576 | |
Selling, general and administrative expenses | 8,814 | | | 4,165 | |
Total operating expenses | 12,514 | | | 8,741 | |
Operating loss | (10,278) | | | (8,325) | |
Interest and other income (expense) | (833) | | | (675) | |
Net loss | $ | (11,111) | | | $ | (9,000) | |
Revenue
The increase in total revenue for the three months ended March 31, 2024 compared to the same periods in 2023 was due to the commercial launch of HEPZATO KIT in the U.S. along with an increase in demand for CHEMOSAT in Europe.
Cost of Goods Sold
The change in cost of goods sold for the three months ended March 31, 2024 compared to the same periods in 2023 is directly related to changes in demand for product revenue.
Research and Development Expenses
Research and development expenses are incurred for the development of HEPZATO and consist primarily of payroll and payments to contract research and development companies. In 2023, these costs primarily related to generating pre-clinical data submission of the NDA and the cost of manufacturing HEPZATO for expanded access protocol sites utilizing HEPZATO KIT prior to FDA approval. The decrease for the three months ended March 31, 2024 compared to the same period in 2023 is due to lower costs associated with NDA submission offset by an increase in medical affairs and regulatory costs associated with an approved product.
Selling, General and Administrative Expenses
Selling, general and administrative expenses consist primarily of payroll, rent and professional services such as accounting, legal, marketing and commercial preparation services. For the three months ended March 31, 2024 compared to the same periods in 2023, selling, general and administrative expenses increased due to activities supporting the commercial launch of HEPZATO.
Interest and other Income/Expense
Interest and other income (expense) in 2024 is primarily related to the change in fair value of the Tranche B Warrants liability, interest income associated with marketable securities offset by interest expense related to our debt instruments. There was a decrease in interest expense for the three months ended March 31, 2024 compared to the same periods in 2023 related to the principal loan payments made during 2023 and 2024.
Liquidity and Capital Resources
At March 31, 2024, we had cash, cash equivalents and restricted cash totaling $11.8 million and short-term investments totaling $15.4 million, as compared to cash, cash equivalents and restricted cash totaling $12.7 million and short-term investments totaling $19.8 million at December 31, 2023. During the three months ended March 31, 2024, we used $9.6 million of cash for operating activities compared to $4.3 million during the three months ended March 31, 2023, and $3.1 million for principal payments during the three months ended March 31, 2024, compared to $6.3 million for principal payments during the three months ended March 31, 2023. At March 31, 2023, we had cash, cash equivalents and restricted cash totaling $24.3 million.
Our future results are subject to substantial risks and uncertainties. We have operated at a loss for our entire history and there can be no assurance that we will ever achieve or maintain profitability. We have historically funded our operations primarily with
proceeds from sales of common stock, warrants and pre-funded warrants for the purchase of common stock, sales of preferred stock, proceeds from the issuance of convertible debt and borrowings under loan and security agreements.
Funding Requirements
If there is a substantial delay in the activation of sites to administer HEPZATO, we expect to need to raise additional capital under structures available to us, including debt and/or equity offerings, which may not be on terms favorable to us. In a substantially delayed site activation scenario, we will not have sufficient funds to meet our obligations within twelve months from the issuance date of these condensed consolidated financial statements. As such, there is uncertainty regarding our ability to maintain liquidity sufficient to operate our business effectively, which raises substantial doubt about our ability to continue as a going concern.
Debt financing and equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If we raise funds through collaborations, or other similar arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs for product candidates and/or grant licenses on terms that may not be favorable to us, any of which may reduce the value of our common stock. If we are unable to raise additional funds through equity or debt financings when needed, we may be required to delay, limit, reduce or terminate our product development or future commercialization efforts or grant rights to develop and market our product candidates to third parties even if we would otherwise prefer to develop and market such product candidates ourselves.
We also expect to use cash and cash equivalents to fund activities relating to commercial support for HEPZATO, CHEMOSAT and any future clinical research trials and operating activities. Our future liquidity and capital requirements will depend on numerous factors, including our ability to successfully commercialize HEPZATO and CHEMOSAT; the cost of and our ability to obtain additional regulatory approvals for HEPZATO and CHEMOSAT in additional jurisdictions and for additional indications; our ability to build a commercial infrastructure for HEPZATO for the treatment of mUM in the United States; obtaining regulatory approvals and complying with applicable laws and regulations; the timing and effectiveness of product commercialization activities, including marketing arrangements; our headcount growth and associated costs as we expand our research and development and establish a commercial infrastructure; the timing and costs involved in preparing, filing, prosecuting, defending and enforcing intellectual property rights; the resolution of any disputes with third parties; and the effect of competing technological and market developments.
Capital Commitments
Our capital commitments over the next twelve months include (a) $6.0 million to satisfy accounts payable, accrued expenses, current lease liabilities and current medac settlement and (b) $7.6 million of loan and convertible note principal payments, if the holders do not elect to convert up to $5.0 million of the notes into equity. Additional capital commitments beyond the next twelve months include (a) $1.0 million of lease liabilities and (b) $0.8 million for settlement of litigation with medac.
Source of Liquidity
ATM Sales Agreement
On August 18, 2020, we entered into a Controlled Equity OfferingSM Sales Agreement (“ATM Sales Agreement”), with Cantor Fitzgerald & Co. (the “Sales Agent”), pursuant to which we may offer and sell, at our sole discretion through the Sales Agent, shares of common stock having an aggregate offering price of up to $17.0 million. To date, we have sold approximately $4.0 million of our common stock, prior to issuance costs, under the ATM Sales Agreement. No sales were made during the three months ended March 31, 2024.
Avenue Loan Agreement
On August 6, 2021, we entered into the Avenue Loan Agreement with Avenue Venture Opportunities Fund, L.P. (the “Lender,” or “Avenue”), as amended on March 31, 2023, for a term loan in an aggregate principal amount of up to $20 million (the “Avenue Loan”). The Avenue Loan bears interest at an annual rate equal to the greater of (a) the sum of 7.7% plus the prime rate as reported in The Wall Street Journal and (b) 10.95%. The interest rate at March 31, 2024 was 16.20%. The Avenue Loan is secured by all of our assets globally, including intellectual property. The Avenue Loan matures on August 1, 2024. On March 15, 2023, we returned to Avenue $4.0 million held in the restricted cash to pay down a portion of the outstanding loan balance, principal payments of $2.1 million and an incremental 4.25% of the final payment of $0.2 million. On March 31, 2023, we reached an agreement to amend the existing loan agreement with Avenue to defer the interest only period to September 30, 2023, with an additional extension option upon the FDA approval for HEPZATO KIT and subsequent receipt of at least $10 million from the sale and issuance of equity securities. In exchange for this extension, the Company agreed to provide Avenue with 34,072 warrants to purchase shares of common stock at an exercise price of $0.01 per warrant share, all of which were exercised in April
2024. On August 14, 2023, the Company received the FDA approval for the HEPZATO KIT and subsequently received over $10 million from the exercise of warrants. At our option, we elected to extend the interest only period to December 31, 2023. Principal payments of approximately $1.0 million began in January 2024.
Private Placements, Common Offering and Warrants
On March 27, 2023, we entered into a securities purchase agreement with certain accredited investors (the “Preferred Purchase Agreement”), pursuant to which we agreed to issue and sell, in a private placement (the “Series F Preferred Offering”), (i) 24,900 shares of our Series F-1 Convertible Preferred Stock, par value $0.01 per share (the “Series F-1 Preferred Stock”), (ii) tranche A warrants (the “Preferred Tranche A Warrant”) to acquire 34,859 shares of Series F-3 Convertible Preferred Stock, par value $0.01 per share (the “Series F-3 Preferred Stock”) and (iii) tranche B warrants (the “Preferred Tranche B Warrant,” together with the Preferred Tranche A Warrant, the “Preferred Warrants”) to acquire 24,900 shares of Series F-4 Convertible Preferred Stock, par value $0.01 per share (the “Series F-4 Preferred Stock”) for an aggregate offering price of $24.9 million before deducting the fees paid to the placement agent and the financial advisors and other financing expenses payable by us.
Also on March 27, 2023, we entered into a securities purchase agreement with the our Chief Executive Officer, Gerard Michel, pursuant to which we agreed to issue and sell, in a private placement (the “Common Offering”, and together with the Series F Preferred Offering, the “Private Placements”), (i) 19,646 shares of common stock, (ii) tranche A warrants to acquire 31,110 shares of common stock (the “Common Tranche A Warrants”, and together with the Preferred Tranche A Warrants, the “Tranche A Warrants”) and (iii) tranche B warrants to acquire 16,666 shares of common stock (the “Common Tranche B Warrants”, and together with the Preferred Tranche B Warrants, the “Tranche B Warrants”) for an approximate aggregate offering price of $0.1 million.
On June 12, 2023, the stockholders approved the Private Placements at the annual general meeting of stockholders and therefore, the Preferred Warrants and Common Warrants issued in the Private Placements are exercisable. The exercise of all such Preferred Warrants and Common Warrants would generate approximately $60.0 million in proceeds. There can be no guarantee that all such Warrants are ever exercised, and if so, there is no guarantee that we will ever receive the full $60.0 million in proceeds. As of March 31, 2024, all of the Preferred Tranche A Warrants were exercised for an aggregate exercise price of $34.9 million into 34,859 shares of Series F-3 Preferred Stock and all of the Common Tranche A Warrants were exercised for an aggregate exercise price of $0.1 million into 31,110 shares of common stock.
As of March 31, 2024, 54,207 shares of our Series F-1, F-2 and F-3 Preferred Stock were converted into 13,853,143 shares of common stock.
On March 14, 2024, we and certain accredited investors (each an “Investor” and collectively, the “Investors”) entered into a securities purchase agreement (the “Securities Purchase Agreement”) pursuant to which we agreed to sell and issue to the Investors in a private placement (the “Private Placement”) (i) an aggregate of 876,627 shares of the Company’s common stock, par value $0.01 per share, at a purchase price of $3.72 per share, and (ii) to certain investors, in lieu of shares of common stock, 1,008,102 pre-funded warrants (the “Pre-Funded Warrants”) at a price per Pre-Funded Warrant of $3.71 (the “Warrant Shares” and together with the Shares, the “Securities”). The Pre-Funded Warrants have an exercise price of $0.01 per share of Common Stock, are immediately exercisable and will remain exercisable until exercised in full.
The Private Placement closed on March 19, 2024. We received gross proceeds of approximately $7.0 million, before deducting offering expenses payable by us.
Critical Accounting Estimates
There have been no material changes to the process of our critical accounting estimates as they were reported in our Annual Report on Form 10-K filed with the SEC on March 26, 2024.
Application of Critical Accounting Policies
Our financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America. There were no material changes to our critical accounting policies as reported in our Annual Report. A description of certain accounting policies that may have a significant impact on amounts reported in the financial statements is disclosed in “Note 3 – Summary of Accounting Policies” to the notes to the consolidated financial statements contained in the Annual Report.
Item 3. Quantitative and Qualitative Disclosures About Market Risk
Not required.
Item 4. Controls and Procedures
Evaluation of Disclosure Controls and Procedures
Management of the Company, with the participation of its Chief Executive Officer and Chief Financial Officer (its Certifying Officers), evaluated the effectiveness of the Company’s disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act. Based on the evaluation as of March 31, 2024, the Company’s Certifying Officers concluded that the Company’s disclosure controls and procedures were effective.
The Company has established disclosure controls and procedures designed to ensure that information required to be disclosed by the Company in the reports that it files or submits under the Exchange Act, is recorded, processed, summarized and reported within the time periods specified in the U.S. Securities and Exchange Commission’s rules and forms, and that such information is accumulated and communicated to management of the Company, with the participation of its Certifying Officers, as appropriate, to allow timely decisions regarding required disclosure.
Changes in Internal Control over Financial Reporting
There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) during the three months ended March 31, 2024, that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
PART II: OTHER INFORMATION
Item 1. Legal Proceedings
From time to time, claims are made against the Company in the ordinary course of business, which could result in litigation. Claims and associated litigation are subject to inherent uncertainties and unfavorable outcomes could occur, such as monetary damages, fines, penalties, or injunctions prohibiting us from selling our products or engaging in other activities.
medac Matter
See Note 15 - “Commitment and Contingencies - Litigation, Claims and Assessments - medac Matter” for more information.
Item 1A. Risk Factors
Our business is subject to various risks and uncertainties that may have a material adverse effect on our business, financial condition or results of operations. You should carefully consider the risks and uncertainties described in the Annual Report on Form 10-K filed on March 26, 2024. Our business faces significant risks and uncertainties, and those described in our Annual Report may not be the only risks and uncertainties we face. Additional risks and uncertainties not presently known to us or that we currently believe are immaterial may also significantly impair our business, financial condition or results of operations. If any of these risks or uncertainties occur, our business, financial condition or results of operations could suffer, the market price of our common stock could decline and you could lose all or part of your investment in our common stock.
As of the date of this Quarterly Report on Form 10-Q, there have been no material changes to the risk factors disclosed in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds
Not applicable.
Item 3. Defaults Upon Senior Securities
Not applicable.
Item 4. Mine Safety Disclosures
Not applicable.
Item 5. Other Information
Not applicable.
Item 6. Exhibits
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Exhibit No. | | Description |
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3.1 | | |
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3.2 | | |
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3.3 | | |
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3.4 | | |
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3.5 | | |
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3.6 | | |
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3.7 | | |
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3.8 | | |
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31.1* | | |
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31.2* | | |
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32.1*+ | | |
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32.2*+ | | |
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101.INS | | XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document. |
| | |
101.SCH | | Inline XBRL Taxonomy Extension Schema Document |
| | |
101.CAL | | Inline XBRL Taxonomy Extension Calculation Linkbase Document |
| | |
101.DEF | | Inline XBRL Taxonomy Extension Definition Linkbase Document |
| | |
101.LAB | | Inline XBRL Taxonomy Extension Label Linkbase Document |
| | |
101.PRE | | Inline XBRL Taxonomy Extension Presentation Linkbase Document |
| | |
104 | | Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101) |
*Filed herewith.
+ This exhibit shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act or the Exchange Act whether made before or after the date hereof and irrespective of any general incorporation language in any filing, except to the extent the Company specifically incorporates it by reference.
DELCATH SYSTEMS, INC.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
| | | | | |
| DELCATH SYSTEMS, INC. |
| |
May 14, 2024 | /s/ Gerard Michel |
| Gerard Michel |
| Chief Executive Officer (Principal Executive Officer) |
| |
May 14, 2024 | /s/ Sandra Pennell |
| Sandra Pennell |
| Principal Financial Officer |
Exhibit 31.1
DELCATH SYSTEMS, INC.
CERTIFICATION
PURSUANT TO RULE 13a-14(a) OR 15d-14(a) OF THE SECURITIES
EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302
OF THE SARBANES-OXLEY ACT OF 2002
I, Gerard Michel, certify that:
1)I have reviewed this Quarterly Report on Form 10-Q of Delcath Systems, Inc.;
2)Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3)Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4)The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5)The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
| | | | | |
May 14, 2024 | |
| |
| /s/ Gerard Michel |
| Gerard Michel |
| Chief Executive Officer (Principal Executive Officer) |
Exhibit 31.2
DELCATH SYSTEMS, INC.
CERTIFICATION
PURSUANT TO RULE 13a-14(a) OR 15d-14(a) OF THE SECURITIES
EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302
OF THE SARBANES-OXLEY ACT OF 2002
I, Sandra Pennell, certify that:
1)I have reviewed this Quarterly Report on Form 10-Q of Delcath Systems, Inc.;
2)Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3)Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4)The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5)The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
| | | | | |
May 14, 2024 | |
| |
| /s/ Sandra Pennell |
| Sandra Pennell |
| Principal Financial Officer |
Exhibit 32.1
DELCATH SYSTEMS, INC.
CERTIFICATION
PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report of DELCATH SYSTEMS, INC. (the “Company”) on Form 10-Q for the period ended March 31, 2024, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Gerard Michel, certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to my knowledge:
(1)The Report fully complies with the requirements of section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and
(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
| | | | | |
May 14, 2024 | |
| |
| /s/ Gerard Michel |
| Gerard Michel |
| Chief Executive Officer (Principal Executive Officer) |
Exhibit 32.2
DELCATH SYSTEMS, INC.
CERTIFICATION
PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report of DELCATH SYSTEMS, INC. (the “Company”) on Form 10-Q for the period ended March 31, 2024, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Sandra Pennell, certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to my knowledge:
(1)The report fully complies with the requirements of section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and
(2)The information contained in the report fairly presents, in all material respects, the financial condition and results of operations of the Company.
| | | | | |
May 14, 2024 | |
| |
| /s/ Sandra Pennell |
| Sandra Pennell |
| Principal Financial Officer |
v3.24.1.1.u2
Cover Page - shares
|
3 Months Ended |
|
Mar. 31, 2024 |
May 09, 2024 |
Cover [Abstract] |
|
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Document Type |
10-Q
|
|
Document Quarterly Report |
true
|
|
Document Period End Date |
Mar. 31, 2024
|
|
Document Transition Report |
false
|
|
Entity File Number |
001-16133
|
|
Entity Registrant Name |
DELCATH SYSTEMS, INC.
|
|
Entity Incorporation, State or Country Code |
DE
|
|
Entity Tax Identification Number |
06-1245881
|
|
Entity Address, Address Line One |
566 Queensbury Avenue
|
|
Entity Address, City or Town |
Queensbury
|
|
Entity Address, State or Province |
NY
|
|
Entity Address, Postal Zip Code |
12804
|
|
City Area Code |
212
|
|
Local Phone Number |
489-2100
|
|
Title of 12(b) Security |
Common stock, $0.01 par value per share
|
|
Trading Symbol |
DCTH
|
|
Security Exchange Name |
NASDAQ
|
|
Entity Current Reporting Status |
Yes
|
|
Entity Interactive Data Current |
Yes
|
|
Entity Filer Category |
Non-accelerated Filer
|
|
Entity Small Business |
true
|
|
Entity Emerging Growth Company |
false
|
|
Entity Shell Company |
false
|
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Entity Common Stock, Shares Outstanding |
|
27,785,803
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Entity Central Index Key |
0000872912
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--12-31
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2024
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Q1
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v3.24.1.1.u2
Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands |
Mar. 31, 2024 |
Dec. 31, 2023 |
Current assets |
|
|
Cash and cash equivalents |
$ 11,760
|
$ 12,646
|
Restricted cash |
50
|
50
|
Short-term investments |
15,360
|
19,808
|
Accounts receivable, net |
1,564
|
241
|
Inventory |
3,634
|
3,322
|
Prepaid expenses and other current assets |
1,278
|
1,091
|
Total current assets |
33,646
|
37,158
|
Property, plant and equipment, net |
1,336
|
1,352
|
Right-of-use assets |
1,117
|
103
|
Total assets |
36,099
|
38,613
|
Current liabilities |
|
|
Accounts payable |
1,487
|
1,012
|
Accrued expenses |
4,395
|
5,249
|
Lease liabilities, current |
102
|
37
|
Loan payable |
2,408
|
5,239
|
Convertible notes payable |
4,949
|
4,911
|
Total current liabilities |
13,341
|
16,448
|
Warrant liability |
6,160
|
5,548
|
Lease Liabilities, non-current |
1,016
|
0
|
Other liabilities, non-current |
962
|
840
|
Total liabilities |
21,479
|
22,836
|
Commitments and contingencies (see Note 15) |
|
|
Stockholders’ equity |
|
|
Preferred stock, $0.01 par value; 10,000,000 shares authorized; 16,809 and 24,819 shares issued and outstanding at March 31, 2024 and December 31, 2023, respectively |
0
|
0
|
Common stock, $0.01 par value; 80,000,000 shares authorized; 25,439,319 shares and 22,761,554 shares issued and outstanding at March 31, 2024 and December 31, 2023, respectively |
254
|
228
|
Additional paid-in capital |
530,482
|
520,576
|
Accumulated deficit |
(516,273)
|
(505,162)
|
Accumulated other comprehensive loss |
157
|
135
|
Total stockholders’ equity |
14,620
|
15,777
|
Total liabilities and stockholders’ equity |
$ 36,099
|
$ 38,613
|
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v3.24.1.1.u2
Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares
|
Mar. 31, 2024 |
Dec. 31, 2023 |
Statement of Financial Position [Abstract] |
|
|
Preferred stock, par value (in dollars per share) |
$ 0.01
|
$ 0.01
|
Preferred stock, shares authorized (in shares) |
10,000,000
|
10,000,000
|
Preferred stock, shares issued (in shares) |
16,809
|
24,819
|
Preferred stock, shares outstanding (in shares) |
16,809
|
24,819
|
Common stock, par value (in dollars per share) |
$ 0.01
|
$ 0.01
|
Common stock, shares authorized (in shares) |
80,000,000
|
80,000,000
|
Common stock, shares issued (in shares) |
25,439,319
|
22,761,554
|
Common stock, shares outstanding (in shares) |
25,439,319
|
22,761,554
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.24.1.1.u2
Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
Mar. 31, 2024 |
Mar. 31, 2023 |
Income Statement [Abstract] |
|
|
Product revenue |
$ 3,139
|
$ 597
|
Other revenue |
0
|
0
|
Total revenues |
3,139
|
597
|
Cost of goods sold |
(903)
|
(181)
|
Gross profit |
2,236
|
416
|
Operating expenses: |
|
|
Research and development expenses |
3,700
|
4,576
|
Selling, general and administrative expenses |
8,814
|
4,165
|
Total operating expenses |
12,514
|
8,741
|
Operating loss |
(10,278)
|
(8,325)
|
Change in fair value of warrant liability |
(612)
|
0
|
Interest expense, net |
(199)
|
(688)
|
Other (expense) income |
(22)
|
13
|
Net loss |
(11,111)
|
(9,000)
|
Other comprehensive (loss) income: |
|
|
Unrealized gain on investments |
8
|
0
|
Foreign currency translation adjustments |
14
|
19
|
Total comprehensive loss |
$ (11,089)
|
$ (8,981)
|
Common share data: |
|
|
Basic loss per common share (in dollars per share) |
$ (0.45)
|
$ (0.77)
|
Diluted loss per common share (in dollars per share) |
$ (0.45)
|
$ (0.77)
|
Weighted average number of basic shares outstanding (in shares) |
24,887,180
|
11,622,384
|
Weighted average number of diluted shares outstanding (in shares) |
24,887,180
|
11,622,384
|
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v3.24.1.1.u2
Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Unaudited) - USD ($) $ in Thousands |
Total |
Stock options |
Employee Stock |
Preferred F-3 Stock |
Preferred Stock |
Preferred Stock
Preferred F-3 Stock
|
Common Stock |
Common Stock
Preferred F-3 Stock
|
Additional Paid in Capital |
Additional Paid in Capital
Stock options
|
Additional Paid in Capital
Employee Stock
|
Additional Paid in Capital
Preferred F-3 Stock
|
Accumulated Deficit |
Accumulated Other Comprehensive Income (Loss) |
Beginning Balance (in shares) at Dec. 31, 2022 |
|
|
|
|
11,357
|
|
10,046,571
|
|
|
|
|
|
|
|
Beginning Balance at Dec. 31, 2022 |
$ (5,859)
|
|
|
|
$ 0
|
|
$ 100
|
|
$ 451,607
|
|
|
|
$ (457,483)
|
$ (83)
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Compensation expense for issuance of stock options |
|
$ 1,661
|
|
|
|
|
|
|
|
$ 1,661
|
|
|
|
|
Private placement -issuance of common shares, net of expenses (in shares) |
|
|
|
|
|
|
19,646
|
|
|
|
|
|
|
|
Private placement -issuance of common shares, net of expenses |
56
|
|
|
|
|
|
$ 1
|
|
55
|
|
|
|
|
|
Issuance of common stock with the employee stock purchase plan (in shares) |
|
|
|
|
|
|
15,417
|
|
|
|
|
|
|
|
Issuance of common stock with the employee stock purchase plan |
47
|
|
|
|
|
|
|
|
47
|
|
|
|
|
|
Net loss |
(9,000)
|
|
|
|
|
|
|
|
|
|
|
|
(9,000)
|
|
Foreign currency translation adjustments |
19
|
|
|
|
|
|
|
|
|
|
|
|
|
19
|
Ending Balance (in shares) at Mar. 31, 2023 |
|
|
|
|
11,357
|
|
10,081,634
|
|
|
|
|
|
|
|
Ending Balance at Mar. 31, 2023 |
(13,076)
|
|
|
|
$ 0
|
|
$ 101
|
|
453,370
|
|
|
|
(466,483)
|
(64)
|
Beginning Balance (in shares) at Dec. 31, 2023 |
|
|
|
|
24,819
|
|
22,761,554
|
|
|
|
|
|
|
|
Beginning Balance at Dec. 31, 2023 |
15,777
|
|
|
|
$ 0
|
|
$ 228
|
|
520,576
|
|
|
|
(505,162)
|
135
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Compensation expense for issuance of stock options |
|
$ 2,895
|
$ 50
|
|
|
|
|
|
|
$ 2,895
|
$ 50
|
|
|
|
Private placement -issuance of common shares, net of expenses (in shares) |
|
|
|
|
|
|
876,627
|
|
|
|
|
|
|
|
Private placement -issuance of common shares, net of expenses |
6,912
|
|
|
|
|
|
$ 8
|
|
6,904
|
|
|
|
|
|
Issuance of common stock with the employee stock purchase plan (in shares) |
|
|
|
|
|
|
21,140
|
|
|
|
|
|
|
|
Issuance of common stock with the employee stock purchase plan |
74
|
|
|
|
|
|
|
|
74
|
|
|
|
|
|
Conversion of shares (in shares) |
|
|
|
|
|
(8,010)
|
|
1,779,998
|
|
|
|
|
|
|
Conversion of shares |
|
|
|
$ 1
|
|
|
|
$ 18
|
|
|
|
$ (17)
|
|
|
Net loss |
(11,111)
|
|
|
|
|
|
|
|
|
|
|
|
(11,111)
|
|
Unrealized gain on investments |
8
|
|
|
|
|
|
|
|
|
|
|
|
|
8
|
Foreign currency translation adjustments |
14
|
|
|
|
|
|
|
|
|
|
|
|
|
14
|
Ending Balance (in shares) at Mar. 31, 2024 |
|
|
|
|
16,809
|
|
25,439,319
|
|
|
|
|
|
|
|
Ending Balance at Mar. 31, 2024 |
$ 14,620
|
|
|
|
$ 0
|
|
$ 254
|
|
$ 530,482
|
|
|
|
$ (516,273)
|
$ 157
|
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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
Mar. 31, 2024 |
Mar. 31, 2023 |
Cash flows from operating activities: |
|
|
Net loss |
$ (11,111)
|
$ (9,000)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Stock option compensation expense |
2,945
|
1,661
|
Depreciation expense |
29
|
30
|
Warrant liability fair value adjustment |
612
|
0
|
Non-cash lease expense |
13
|
100
|
Amortization of debt discount |
261
|
194
|
Interest expense accrued related to convertible notes |
40
|
27
|
Amortization of premiums and discounts on marketable securities |
(229)
|
0
|
Changes in operating assets and liabilities: |
|
|
Prepaid expenses and other assets |
(174)
|
14
|
Accounts receivable |
(1,323)
|
(92)
|
Inventory |
(312)
|
(339)
|
Accounts payable and accrued expenses |
(507)
|
3,221
|
Other liabilities, non-current |
172
|
(80)
|
Deferred revenue |
0
|
0
|
Net cash used in operating activities |
(9,584)
|
(4,264)
|
Cash flows from investing activities: |
|
|
Purchase of investment |
(10,327)
|
0
|
Maturities of investments |
15,000
|
0
|
Purchase of property, plant and equipment |
(13)
|
0
|
Net cash provided by investing activities |
4,660
|
0
|
Cash flows from financing activities: |
|
|
Proceeds from private placement |
7,000
|
22,960
|
Proceeds from the issuance of common stock relating to the employee stock purchase plan |
75
|
47
|
Repayment of debt |
(3,054)
|
(6,313)
|
Proceeds from exercise of warrants |
0
|
0
|
Proceeds from exercise of stock options |
0
|
0
|
Net cash provided by financing activities |
4,021
|
16,694
|
Foreign currency effects on cash |
17
|
20
|
Net (decrease) increase in total cash |
(886)
|
12,450
|
Total Cash, Cash Equivalents and Restricted Cash: |
|
|
Beginning of period |
12,696
|
11,822
|
End of period |
11,810
|
24,272
|
Cash, Cash Equivalents and Restricted Cash consisted of the following: |
|
|
Cash and Cash Equivalents |
11,760
|
24,222
|
Restricted Cash |
50
|
50
|
Total cash, cash equivalents and restricted cash shown in the statements of cash flows |
11,810
|
24,272
|
Cash paid during the periods for: |
|
|
Interest expense |
250
|
491
|
Supplemental Disclosure of Non-Cash Investing and Financing Activities: |
|
|
Right of use assets obtained in exchange for lease obligations |
$ 1,029
|
$ 0
|
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v3.24.1.1.u2
General
|
3 Months Ended |
Mar. 31, 2024 |
Accounting Policies [Abstract] |
|
General |
General The unaudited interim condensed consolidated financial statements of Delcath Systems, Inc. (“Delcath” or the “Company”) as of and for the three months ended March 31, 2024 and 2023 should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 (the “Annual Report”), which was filed with the Securities and Exchange Commission (the “SEC”) on March 26, 2024 and may also be found on the Company’s website (www.delcath.com). In these notes to the interim condensed consolidated financial statements the terms “us”, “we” or “our” refer to Delcath and its consolidated subsidiaries. Description of Business The Company is an interventional oncology company focused on the treatment of primary and cancers metastatic to the liver. The Company’s lead product, the HEPZATOTM KIT (melphalan for Injection/Hepatic Delivery System), a drug/device combination product, was approved by the US Food and Drug Administration (the “FDA”) on August 14, 2023, indicated as a liver-directed treatment for adult patients with uveal melanoma with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection, or radiation. The first commercial use of HEPZATO KIT (“HEPZATO”) for the treatment of metastatic uveal melanoma (“mUM”) occurred in January 2024. In the United States, HEPZATO is considered a combination drug and device product and is regulated as a drug by the FDA. Primary jurisdiction for regulation of HEPZATO has been assigned to the FDA’s Center for Drug Evaluation and Research. The FDA has granted Delcath six orphan drug designations (five for melphalan in the treatment of patients with ocular (uveal) melanoma, cutaneous melanoma, intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and neuroendocrine tumor indications and one for doxorubicin in the treatment of patients with hepatocellular carcinoma). The Company has sufficient raw material and component constituent parts of HEPZATO KIT to meet the first year of its anticipated demand and it intends to manage supply chain risk through stockpiled inventory and contracting with multiple suppliers for critical components. In Europe, the hepatic delivery system is a stand-alone medical device having the same device components as HEPZATO, but without the melphalan hydrochloride and is approved for sale under the trade name CHEMOSAT Hepatic Delivery System for Melphalan (“CHEMOSAT”), where it has been used at major medical centers to treat a wide range of cancers in the liver. On February 28, 2022, CHEMOSAT received Medical Device Regulation (MDR) certification under the European Medical Devices Regulation (EU) 2017/745, which may be considered by jurisdictions when evaluating reimbursement. To support the New Drug Application for HEPZATO the Company conducted the FOCUS Clinical Trial for Patients with metastatic hepatic dominant Uveal Melanoma (the “FOCUS Trial”), a global registration clinical trial that investigated objective response rate in patients with mUM. The current focus of the Company’s clinical development program is to generate clinical data for CHEMOSAT and HEPZATO either as monotherapy or in combination with immunotherapy. The Company expects that this will support increased clinical adoption of and reimbursement for CHEMOSAT in Europe, and to support reimbursement in various jurisdictions, including the United States. In addition to HEPZATO’s use to treat mUM, the Company believes that HEPZATO has the potential to treat cancers in the liver, such as metastatic colorectal cancer, metastatic neuroendocrine tumors, metastatic breast cancer and intrahepatic cholangiocarcinoma, and plans to begin one or more studies of HEPZATO KIT to treat such conditions in 2024. The Company believes that those and similar disease states are areas of unmet medical needs that represent significant market opportunities. Risks and Uncertainties As detailed in the Company’s 2023 Annual Report filed on Form 10-K, the Company is subject to risks common to companies in the biopharmaceutical industry with FDA-approved products and planned clinical development activities, including, but not limited to, risks associated with successfully launching and commercializing the products; further developing HEPZATO to potentially treat other cancers in the liver and the Company’s ability to obtain any additional regulatory approval of such products in the United States and obtaining regulatory approval in other geographic markets; the uncertainty relating to the broad adoption of any approved products by physicians and consumers; and the impacts of significant competition. In addition, high rates of inflation have resulted in the U.S. Federal Reserve raising interest rates. Increases in interest rates, especially if coupled with reduced government spending and volatility in financial markets, may further increase economic uncertainty and heighten these risks. Furthermore, if additional banks and financial institutions enter receivership or become insolvent in the future in response to financial conditions affecting the banking system and financial markets, the Company or its partners’ ability to access existing cash, cash equivalents and investments may be threatened and could have a material adverse effect on the Company’s business and financial condition, including the Company’s ability to access additional capital on favorable terms, or at all, which could in the future negatively affect the Company’s ability to pursue its business strategy. Liquidity and Going Concern On March 31, 2024, the Company had cash, cash equivalents and restricted cash totaling $11.8 million and short-term investments totaling $15.4 million, as compared to cash, cash equivalents and restricted cash totaling $12.7 million and short-term investments totaling $19.8 million at December 31, 2023. During the three months ended March 31, 2024, the Company used $9.6 million of cash in its operating activities and $3.1 million for principal payments. The Company’s future results are subject to substantial risks and uncertainties. The Company has operated at a loss for its entire history and there can be no assurance that it will ever achieve or maintain profitability. The Company has historically funded its operations primarily with proceeds from sales of common stock, warrants and pre-funded warrants for the purchase of common stock, sales of preferred stock, proceeds from the issuance of convertible debt and borrowings under loan and security agreements. If there is a substantial delay in the activation of sites to administer HEPZATO, the Company expects to need to raise additional capital under structures available to the Company, including debt and/or equity offerings, which may not be on favorable terms. In a substantially delayed site activation scenario, the Company would not have sufficient funds to meet its obligations within twelve months from the issuance date of these condensed consolidated financial statements. As such, there is uncertainty regarding the Company’s ability to maintain liquidity sufficient to operate its business effectively, which raises substantial doubt about the Company’s ability to continue as a going concern. Debt financing and equity financing, if available, may involve agreements that include covenants limiting or restricting the Company’s ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If the Company raises funds through collaborations or other similar arrangements with third parties, it may have to relinquish valuable rights to its technologies, future revenue streams, research programs for product candidates and/or grant licenses on terms that may not be favorable to the Company, any of which may reduce the value of its common stock. If the Company is unable to raise additional funds through equity or debt financings when needed, it may be required to delay, limit, reduce or terminate its product development or future commercialization efforts or grant rights to develop and market its product candidates to third parties even if the Company would otherwise prefer to develop and market such product candidates itself. The Company also expects to use cash and cash equivalents to fund activities relating to commercial support for HEPZATO, CHEMOSAT and any future clinical research trials and operating activities. The Company’s future liquidity and capital requirements will depend on numerous factors, including the initiation and progress of clinical trials and research and product development programs; obtaining regulatory approvals and complying with applicable laws and regulations; the timing and effectiveness of product commercialization activities, including marketing arrangements; the timing and costs involved in preparing, filing, prosecuting, defending and enforcing intellectual property rights; the resolution of any disputes with third parties; and the effect of competing technological and market developments. The Company’s capital commitments over the next twelve months include (a) $6.0 million to satisfy accounts payable, accrued expenses, current lease liabilities and current medac settlement and (b) $7.6 million of loan and convertible note principal payments, if the holders do not elect to convert up to $5.0 million of the notes into equity. Additional capital commitments beyond the next twelve months include (a) $1.0 million of lease liabilities; and (b) $0.8 million for settlement of litigation with medac. Basis of Presentation These interim condensed consolidated financial statements are unaudited and were prepared by the Company in accordance with generally accepted accounting principles in the United States of America (GAAP) and with the SEC’s instructions to Form 10-Q and Article 10 of Regulation S-X. They include the accounts of all wholly owned subsidiaries and all significant inter-company accounts and transactions have been eliminated in consolidation. The preparation of interim condensed consolidated financial statements requires management to make assumptions and estimates that impact the amounts reported. These interim condensed consolidated financial statements reflect all adjustments, consisting of normal recurring accruals, necessary for a fair presentation of the Company’s results of operations, financial position and cash flows for the interim periods ended March 31, 2024 and 2023; however, certain information and footnote disclosures normally included in our audited consolidated financial statements which were included in our Annual Report have been condensed or omitted as permitted by GAAP. It is important to note that the Company’s results of operations and cash flows for interim periods are not necessarily indicative of the results of operations and cash flows to be expected for a full fiscal year or any interim period. Significant Accounting Policies There have been no material changes to our significant accounting policies as set forth in Note 3 Summary of Significant Accounting Policies to the consolidated financial statements included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023. Recent Accounting Pronouncements No new accounting standards were adopted during the three months ended March 31, 2024
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- DefinitionThe entire disclosure for the general note to the financial statements for the reporting entity which may include, descriptions of the basis of presentation, business description, significant accounting policies, consolidations, reclassifications, new pronouncements not yet adopted and changes in accounting principles.
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v3.24.1.1.u2
Revenue
|
3 Months Ended |
Mar. 31, 2024 |
Revenue from Contract with Customer [Abstract] |
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Revenue |
Revenue The Company recognizes product revenue from sales of HEPZATO in the United States and CHEMOSAT in certain European countries in accordance with the five-step model in Accounting Standards Codification (“ASC”) 606, Revenue Recognition: (i) identify contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenues when (or as) the Company satisfies the performance obligation. Under this revenue standard, the Company recognizes revenue when its customer obtains control of the promised goods, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods. There are no contractual rights of returns, refunds or similar obligations. HEPZATO The Company ships and sells the HEPZATO directly to hospitals and treating centers based on approved agreements. Prior to use of the HEPZATO, the inventory is considered on consignment in which the Company retains title to the product. The Company recognizes HEPZATO revenue, based on contracted rates stated in an approved contract or purchase order, upon completion of the procedure as evidenced through the Company’s required Risk Evaluation and Mitigation Strategy (“REMS”) system. There is no obligation for the hospitals or treating centers to use the consigned HEPZATO, and the Company has no contractual right to receive payment until the product is used in a procedure and transfer of control is completed. See Note 5 for further information for consignment inventory. CHEMOSAT CHEMOSAT is sold directly to hospitals in the European Union and United Kingdom based on contracted rates in an approved contract or sales order. The Company recognizes product revenue from sales of CHEMOSAT upon shipment. Revenue by product for the periods indicated were as follows: | | | | | | | | | | | | | | | | | Three Months Ended March 31, | (In thousands) | | 2024 | | 2023 | CHEMOSAT | | $ | 1,131 | | | $ | 597 | | HEPZATO KIT | | 2,008 | | | — | | Total revenue | | $ | 3,139 | | | $ | 597 | |
Concentration of Credit Risk Potential credit risk exposure for both HEPZATO KIT and CHEMOSAT has been evaluated for the Company’s accounts receivable in accordance with ASC 326, Financial Instruments - Credit Losses. The loss percentage is calculated through the use of current and historical economic and financial information. As of March 31, 2024, there were no estimated losses applied to the accounts receivables balance. The Company’s total percentage of revenue and accounts receivable concentrations from a single customer consisted of the following: | | | | | | | | | | | | For the quarter ended and as of | Revenue | | Accounts Receivable | March 31, 2024 | 52.4 | % | | 46.7 | % | March 31, 2023 | 24.2 | % | | 21.8 | % |
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- DefinitionThe entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts.
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v3.24.1.1.u2
Cash, Cash Equivalents and Restricted Cash
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3 Months Ended |
Mar. 31, 2024 |
Cash and Cash Equivalents [Abstract] |
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Cash, Cash Equivalents and Restricted Cash |
Cash, Cash Equivalents and Restricted Cash Cash and cash equivalents that are restricted as to withdrawal or use under the terms of certain contractual agreements are recorded in Restricted Cash on the balance sheet. Restricted cash does not include required minimum balances. Cash, cash equivalents, and restricted cash balances were as follows: | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | Cash and cash equivalents | $ | 11,760 | | | $ | 12,646 | | Security for credit cards | 50 | | | 50 | | Total cash, cash equivalents and restricted cash shown in the statements of cash flows | $ | 11,810 | | | $ | 12,696 | |
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- DefinitionThe entire disclosure for cash and cash equivalent footnotes, which may include the types of deposits and money market instruments, applicable carrying amounts, restricted amounts and compensating balance arrangements. Cash and equivalents include: (1) currency on hand (2) demand deposits with banks or financial institutions (3) other kinds of accounts that have the general characteristics of demand deposits (4) short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Generally, only investments maturing within three months from the date of acquisition qualify.
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v3.24.1.1.u2
Investments
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3 Months Ended |
Mar. 31, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Investments |
Investments Marketable debt securities held by the Company are classified as available-for-sale pursuant to ASC 320, Investments - Debt and Equity Securities, and carried at fair value in the accompanying condensed consolidated balance sheets. The following table summarizes the gross unrealized gains on the Company’s marketable securities as of March 31, 2024:
| | | | | | | | | | | | | | | | | | | | | | | March 31, 2024 | | | | | Gross Unrealized | | | (In thousands) | | Amortized Cost | | Gains | | Estimated Fair Value | U.S. government agency bonds | | $ | 15,195 | | | $ | 165 | | | $ | 15,360 | | | | $ | 15,195 | | | $ | 165 | | | $ | 15,360 | | Short-term investments | | | | | | $ | 15,360 | |
As of March 31, 2024, there was $0.2 million of interest receivable related to the outstanding debt securities held by the Company. The following table summarizes the gross unrealized gains on the Company’s marketable securities as of December 31, 2023: | | | | | | | | | | | | | | | | | | | | | | | December 31, 2023 | | | | | Gross Unrealized | | | (in thousands) | | Amortized Cost | | Gains | | Estimated Fair Value | U.S. government agency bonds | | $ | 19,651 | | | $ | 157 | | | $ | 19,808 | | | | $ | 19,651 | | | $ | 157 | | | $ | 19,808 | | Short-term investments | | | | | | $ | 19,808 | | | | | | | | |
As of December 31, 2023, there was $0.2 million of interest receivable related to the outstanding debt securities held by the Company.
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v3.24.1.1.u2
Inventory
|
3 Months Ended |
Mar. 31, 2024 |
Inventory Disclosure [Abstract] |
|
Inventory |
InventoryInventory consists of the following: | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | Raw materials | $ | 1,335 | | | $ | 1,443 | | Work-in-process | 1,983 | | | 1,753 | | Finished goods | 316 | | | 126 | | Total inventory | $ | 3,634 | | | $ | 3,322 | |
The Company has consignment agreements with approved hospitals and treatment centers. As of March 31, 2024, there was $0.2 million in finished goods held at hospitals and treatment centers.
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v3.24.1.1.u2
Prepaid Expenses and Other Current Assets
|
3 Months Ended |
Mar. 31, 2024 |
Prepaid Expense and Other Assets, Current [Abstract] |
|
Prepaid Expenses and Other Current Assets |
Prepaid Expenses and Other Current Assets Prepaid expenses and other current assets consist of the following: | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | Clinical trial expenses | $ | 222 | | | $ | 222 | | Insurance premiums | 173 | | | 157 | | Professional services | 332 | | | 133 | | Interest Receivable | 164 | | | 151 | | Other | 387 | | | 428 | | Total prepaid expenses and other current assets | $ | 1,278 | | | $ | 1,091 | |
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v3.24.1.1.u2
Property, Plant, and Equipment
|
3 Months Ended |
Mar. 31, 2024 |
Property, Plant and Equipment [Abstract] |
|
Property, Plant, and Equipment |
Property, Plant, and EquipmentProperty, plant, and equipment consist of the following: | | | | | | | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | | Estimated Useful Life | Buildings and land | $ | 1,318 | | | $ | 1,318 | | | 30 years - Buildings | Enterprise hardware and software | 1,857 | | | 1,857 | | | 3 years | Leaseholds | 1,779 | | | 1,787 | | | Lesser of lease term or estimated useful life | Equipment | 1,262 | | | 1,263 | | | 7 years | Furniture | 215 | | | 202 | | | 5 years | Property, plant and equipment, gross | 6,431 | | | 6,427 | | | | Accumulated depreciation | (5,095) | | | (5,075) | | | | Property, plant and equipment, net | $ | 1,336 | | | $ | 1,352 | | | |
Depreciation expense for the three months ended March 31, 2024 and 2023 was less than $0.1 million for each period.
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- DefinitionThe entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections.
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v3.24.1.1.u2
Accrued Expenses
|
3 Months Ended |
Mar. 31, 2024 |
Payables and Accruals [Abstract] |
|
Accrued Expenses |
Accrued ExpensesAccrued expenses consist of the following: | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | Clinical expenses | $ | 1,064 | | | $ | 1,129 | | Compensation, excluding taxes | 1,567 | | | 1,859 | | Professional fees | 252 | | | 272 | | Interest on convertible note | 753 | | | 713 | | Inventory | 12 | | | 585 | | Other | 747 | | | 691 | | Total accrued expenses | $ | 4,395 | | | $ | 5,249 | |
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- DefinitionThe entire disclosure for accounts payable and accrued liabilities at the end of the reporting period.
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v3.24.1.1.u2
Leases
|
3 Months Ended |
Mar. 31, 2024 |
Leases [Abstract] |
|
Leases |
Leases The Company recognizes right-of-use (“ROU”) assets and lease liabilities when it obtains the right to control an asset under a leasing arrangement with an initial term greater than twelve months. The Company leases its facilities under non-cancellable operating and financing leases. The Company evaluates the nature of each lease at the inception of an arrangement to determine whether it is an operating or financing lease and recognizes the ROU asset and lease liabilities based on the present value of future minimum lease payments over the expected lease term. The Company’s leases do not generally contain an implicit interest rate and therefore the Company uses the incremental borrowing rate it would expect to pay to borrow on a similar collateralized basis over a similar term in order to determine the present value of its lease payments. For the three months ended March 31, 2024 and 2023, the Company recognized less than $0.1 million of operating lease expense in the U.S. and less than $0.1 million of operating lease expense in Ireland for the same periods. In 2021, the Company entered into a sub-lease agreement (the “2021 Sub-Lease”) with its previous sub-lessee pursuant to which, effective August 2, 2021, the previous sub-lessee would become the lessee and the Company would then sublease its portion of the premises in Galway, Ireland from the previous sub-lessee. The Company’s annual rent expense under the 2021 Sub-Lease is less than $0.1 million for a term of 5 years. In 2020, the Company entered into an amendment to a sub-lease agreement executed in 2016 for office space at 1633 Broadway, New York, New York. The term of the sub-lease agreement began in April 2016 and, pursuant to amendments, was extended through August 2023. As of August 31, 2023, the lease was month-to-month. No ROU assets or lease liabilities were recognized on the balance sheet as of December 31, 2023 for this arrangement. The Company ended the sublease for its former corporate offices at 1633 Broadway, New York, New York in February 2024. On January 18, 2024, the Company entered into a lease agreement (the “Queensbury Lease”) to lease approximately 18,000 square feet of manufacturing and office space in Queensbury, New York (the “Premises”). The initial term of the lease is five years with a right to extend the lease by an additional five years, exercisable under certain conditions set forth in the Queensbury Lease. The Company’s annual rent expense under the Queensbury Lease is less than $0.2 million for a term of 5 years. The following table summarizes the Company’s operating leases as of March 31, 2024: | | | | | | | | | | | | | | | | | | (In thousands) | U.S. | | Ireland | | Total | Operating cash flows for operating leases | $ | 4 | | | $ | 9 | | | $ | 13 | | Weighted average remaining lease term | 9.8 | | 2.3 | | | Weighted average discount rate - operating leases | 8 | % | | 8 | % | | |
Remaining maturities of the Company’s operating leases, excluding short-term leases, are as follows: | | | | | | | | | | | | | | | | | | (In thousands) | U.S. | | Ireland | | Total | Year ended December 31, 2024 | $ | 108 | | | $ | 32 | | | $ | 140 | | Year ended December 31, 2025 | 144 | | | 43 | | | 187 | | Year ended December 31, 2026 | 144 | | | 25 | | | 169 | | Year ended December 31, 2027 | 148 | | | — | | | 148 | | Year ended December 31, 2028 | 153 | | | — | | | 153 | | Thereafter | 800 | | | — | | | 800 | | Total | 1,497 | | | 100 | | | 1,597 | | Less present value discount | (471) | | | (8) | | | (479) | | Operating lease liabilities included in the condensed consolidated balance sheets at March 31, 2024 | $ | 1,026 | | | $ | 92 | | | $ | 1,118 | |
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Leases |
Leases The Company recognizes right-of-use (“ROU”) assets and lease liabilities when it obtains the right to control an asset under a leasing arrangement with an initial term greater than twelve months. The Company leases its facilities under non-cancellable operating and financing leases. The Company evaluates the nature of each lease at the inception of an arrangement to determine whether it is an operating or financing lease and recognizes the ROU asset and lease liabilities based on the present value of future minimum lease payments over the expected lease term. The Company’s leases do not generally contain an implicit interest rate and therefore the Company uses the incremental borrowing rate it would expect to pay to borrow on a similar collateralized basis over a similar term in order to determine the present value of its lease payments. For the three months ended March 31, 2024 and 2023, the Company recognized less than $0.1 million of operating lease expense in the U.S. and less than $0.1 million of operating lease expense in Ireland for the same periods. In 2021, the Company entered into a sub-lease agreement (the “2021 Sub-Lease”) with its previous sub-lessee pursuant to which, effective August 2, 2021, the previous sub-lessee would become the lessee and the Company would then sublease its portion of the premises in Galway, Ireland from the previous sub-lessee. The Company’s annual rent expense under the 2021 Sub-Lease is less than $0.1 million for a term of 5 years. In 2020, the Company entered into an amendment to a sub-lease agreement executed in 2016 for office space at 1633 Broadway, New York, New York. The term of the sub-lease agreement began in April 2016 and, pursuant to amendments, was extended through August 2023. As of August 31, 2023, the lease was month-to-month. No ROU assets or lease liabilities were recognized on the balance sheet as of December 31, 2023 for this arrangement. The Company ended the sublease for its former corporate offices at 1633 Broadway, New York, New York in February 2024. On January 18, 2024, the Company entered into a lease agreement (the “Queensbury Lease”) to lease approximately 18,000 square feet of manufacturing and office space in Queensbury, New York (the “Premises”). The initial term of the lease is five years with a right to extend the lease by an additional five years, exercisable under certain conditions set forth in the Queensbury Lease. The Company’s annual rent expense under the Queensbury Lease is less than $0.2 million for a term of 5 years. The following table summarizes the Company’s operating leases as of March 31, 2024: | | | | | | | | | | | | | | | | | | (In thousands) | U.S. | | Ireland | | Total | Operating cash flows for operating leases | $ | 4 | | | $ | 9 | | | $ | 13 | | Weighted average remaining lease term | 9.8 | | 2.3 | | | Weighted average discount rate - operating leases | 8 | % | | 8 | % | | |
Remaining maturities of the Company’s operating leases, excluding short-term leases, are as follows: | | | | | | | | | | | | | | | | | | (In thousands) | U.S. | | Ireland | | Total | Year ended December 31, 2024 | $ | 108 | | | $ | 32 | | | $ | 140 | | Year ended December 31, 2025 | 144 | | | 43 | | | 187 | | Year ended December 31, 2026 | 144 | | | 25 | | | 169 | | Year ended December 31, 2027 | 148 | | | — | | | 148 | | Year ended December 31, 2028 | 153 | | | — | | | 153 | | Thereafter | 800 | | | — | | | 800 | | Total | 1,497 | | | 100 | | | 1,597 | | Less present value discount | (471) | | | (8) | | | (479) | | Operating lease liabilities included in the condensed consolidated balance sheets at March 31, 2024 | $ | 1,026 | | | $ | 92 | | | $ | 1,118 | |
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v3.24.1.1.u2
Loans and Convertible Notes Payable
|
3 Months Ended |
Mar. 31, 2024 |
Debt Disclosure [Abstract] |
|
Loans and Convertible Notes Payable |
Loans and Convertible Notes Payable | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | March 31, 2024 | | December 31, 2023 | (In thousands) | Gross | | Discount | | Net | | Gross | | Discount | | Net | Loans payable, current1 | $ | 2,557 | | | $ | (149) | | | $ | 2,408 | | | $ | 5,610 | | | $ | (371) | | | $ | 5,239 | | Convertible notes payable - current | 5,000 | | | (51) | | | 4,949 | | | 5,000 | | | (89) | | | 4,911 | | Total - Loans and notes payable | $ | 7,557 | | | $ | (200) | | | $ | 7,357 | | | $ | 10,610 | | | $ | (460) | | | $ | 10,150 | |
1 The gross amount includes the 4.25% final payment of $0.5 million.
Term Loan from Avenue Venture Opportunities Fund, L.P. On August 6, 2021, the Company entered into a Loan and Security Agreement (the “Avenue Loan Agreement”) with Avenue Venture Opportunities Fund, L.P. (the “Lender,” or “Avenue”) for a term loan in an aggregate principal amount of up to $20.0 million (the “Avenue Loan”). The Avenue Loan bears interest at an annual rate equal to the greater of (a) the sum of 7.70% plus the prime rate as reported in The Wall Street Journal and (b) 10.95%. The interest rate at March 31, 2024 was 16.20%. The Avenue Loan is secured by all of the Company’s assets globally, including intellectual property. The Avenue Loan matures on August 1, 2024.
The initial tranche of the Avenue Loan was $15.0 million, including $4.0 million that was funded into a restricted account. On March 15, 2023, the Company returned to Avenue $4.0 million held as restricted cash to pay down a portion of the outstanding loan balance, principal payments of $2.1 million and an incremental 4.25% of the final payment of $0.2 million. On March 31, 2023, the Avenue Loan Agreement was amended (the “Avenue Amendment”) to defer the interest only period to September 30, 2023, with an additional extension option upon FDA Approval for the HEPZATO KIT and subsequent receipt of at least $10 million from the sale and issuance of equity securities. On August 14, 2023, the Company received FDA approval and has subsequently received over $10 million from the exercise of Tranche A Preferred Warrants. At the Company’s option, it elected to extend the interest only period to December 31, 2023 and monthly principal payments of approximately $1.0 million began in January 2024. Up to $3.0 million of the principal amount of the Avenue Loan outstanding may be converted, at Avenue’s option, into shares of the Company’s common stock at a conversion price of $11.98 per share. The Avenue Loan Agreement requires the Company to make and maintain representations and warranties and other agreements that are customary in loan agreements of this type. The Avenue Loan Agreement also contains customary events of default, including non-payment of principal or interest, violations of covenants, bankruptcy and material judgements. In connection with the initial entry into the Avenue Loan Agreement, the Company issued warrants to Avenue (the “Initial Avenue Warrant”) to purchase 127,755 shares of common stock at an exercise price per share equal to $0.01. Additionally, in connection with the Avenue Amendment, the Company issued to Avenue a warrant to purchase 34,072 shares of common stock at an exercise price per share equal to $0.01. Both the Initial Avenue Warrant and the warrant to purchase 34,072 shares of common stock were exercised in full in April 2024. The Company determined that the embedded conversion option associated with the Avenue Loan did not require bifurcation and met the criteria for equity classification. In addition, the amendment was recorded under debt modification guidance. Aggregate debt discount amortization of $0.3 million and $0.2 million was recorded during the three months ended March 31, 2024 and 2023, respectively. Interest expense incurred was $0.3 million and $0.5 million for the three months ended March 31, 2024 and 2023, respectively. Convertible Notes Payable The Company has $2.0 million of principal outstanding related to Senior Secured Promissory Notes (the “Rosalind Notes”) which bear interest at 8% per annum. Pursuant to the original terms, the Rosalind Notes were convertible into Series E Preferred Stock at a price of $1,500 per share and were to mature on July 16, 2021. On August 6, 2021, the Company executed an agreement to amend the Rosalind Notes to (i) reduce the conversion price to $1,198 per share of the Company’s Series E Preferred Stock; and (ii) extend the maturity date to October 30, 2024. In addition, the holders of the Rosalind Notes agreed to subordinate all of the Company’s indebtedness and obligations to Avenue and all of the holders’ security interest to the Avenue Loan and Avenue’s security interest in the Company’s property. Interest expense accrued relating to the Rosalind Notes was less than $0.1 million for both the three months ended March 31, 2024 and 2023.
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- DefinitionThe entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.
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v3.24.1.1.u2
Preferred Purchase Agreement
|
3 Months Ended |
Mar. 31, 2024 |
Preferred Purchase Agreement [Abstract] |
|
Preferred Purchase Agreement |
Preferred Purchase Agreement On March 27, 2023, we entered into a securities purchase agreement with certain accredited investors (the “Preferred Purchase Agreement”), pursuant to which on March 29, 2023, the Company issued and sold, in a private placement (the “Series F Preferred Offering”), (i) 24,900 shares of Series F-1 Convertible Preferred Stock, par value $0.01 per share (the “Series F-1 Preferred Stock”), (ii) tranche A warrants (the “Preferred Tranche A Warrants”) to acquire 34,859 shares of Series F-3 Convertible Preferred Stock, par value $0.01 per share (the “Series F-3 Preferred Stock”) and (iii) tranche B warrants (the “Preferred Tranche B Warrants”, together with the Preferred Tranche A Warrant, the “Preferred Warrants”) to acquire 24,900 shares of Series F-4 Convertible Preferred Stock, par value $0.01 per share (the “Series F-4 Preferred Stock”) for an aggregate offering price of $24.9 million before deducting the fees paid to the placement agent and the financial advisors and other financing expenses payable by the Company.
The gross proceeds of $24.9 million from the Series F Preferred Offering have been allocated first to the Preferred Warrant liabilities at their fair value of $4.9 million, with the residual of $20.0 million being allocated to the Series F-1 Preferred Stock. As of March 31, 2024, all of the Preferred Tranche A Warrants were exercised for an aggregate exercise price of $34.9 million. The Preferred Tranche B Warrants are exercisable for 24,900 shares of Series F-4 Preferred Stock, with an aggregate exercise price of $24.9 million until the earlier of (i) 21 days following the Company’s announcement of receipt of at least $10 million in quarterly U.S. revenue from the commercialization of HEPZATO and (ii) March 31, 2026. Pursuant to the Certificate of Designation of Preferences, Rights and Limitations of the Series F Convertible Voting Preferred Stock (the “Certificate of Designation”), each share of Series F-1 Preferred Stock automatically converted into shares of common stock and/or, if applicable (in accordance with the beneficial ownership limitations then in effect), shares of Series F-2 Preferred Stock, par value $0.01 per share (the “Series F-2 Preferred Stock” and, together with the Series F-1 Preferred Stock, the Series F-3 Preferred Stock and the Series F-4 Preferred Stock, the “Series F Preferred Stock”) in lieu of common stock. Subject to limitations set forth in the Certificate of Designation, the shares of Series F-2, F-3 and F-4 Preferred Stock are convertible into common stock at the option of the holder at the conversion price of $3.30 per share, $4.50 per share and $6.00 per share, respectively, rounded down to the nearest whole share, and in each case subject to the terms and limitations contained in the Certificate of Designation. As of March 31, 2024, 54,207 shares of the Company’s Series F-1, F-2 and F-3 Preferred Stock were converted into 13,853,143 shares of common stock. As of March 31, 2024, there were 2,542 shares of Series F-2 Preferred Stock, 3,010 shares of Series F-3 Preferred Stock and no shares of Series F-4 Preferred Stock outstanding. The Series F-2, F-3 and F-4 Preferred Stock are not mandatorily redeemable, redeemable at the holder’s election or contingently redeemable at the holder’s election (at this point, a Deemed Liquidation Event would potentially trigger pro rata liquidation payments to the preferred and common stockholders on a pro rata “as converted” basis). Accordingly, the Series F-2, F-3 and F-4 Preferred are now classified as permanent equity. The Company determined that the outstanding Preferred Warrants should be liability-classified. See Note 16 for a discussion of the accounting treatment of the Common Warrants and Preferred Warrants.
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v3.24.1.1.u2
Stockholders' Equity
|
3 Months Ended |
Mar. 31, 2024 |
Stockholders' Equity Note [Abstract] |
|
Stockholders' Equity |
Stockholders’ Equity Public and Private Placements Common Purchase Agreement On March 27, 2023, the Company entered into a securities purchase agreement (the “Common Purchase Agreement”) with the Company’s Chief Executive Officer, Gerard Michel, pursuant to which the Company agreed to issue and sell, in a private placement (the “Common Offering”) shares of common stock, tranche A warrants (“Common Tranche A Warrants”) to acquire 31,110 shares of common stock, tranche B warrants (“Common Tranche B Warrants”, together with the Common Tranche A Warrants, the “Common Warrants”) to acquire 16,666 shares of common stock. On March 29, 2023, the Company closed the Common Offering. The aggregate exercise price of the Common Tranche A Warrants issued pursuant to the Common Offering is approximately $0.1 million. On August 14, 2023, the Company announced the receipt of the FDA Approval and all Common Tranche A Warrants were exercised and converted into 31,110 shares of common stock. The aggregate exercise price of the Common Tranche B Warrants issued in the Common Offering is approximately $0.1 million. The Common Tranche B Warrants are exercisable for an aggregate of 16,666 shares of common stock until the earlier of 21 days following the Company’s announcement of receipt of recording at least $10 million in quarterly U.S. revenue from the commercialization of HEPZATO and March 31, 2026. Securities Purchase Agreement On March 14, 2024, the Company and certain accredited investors (each an “Investor” and collectively, the “Investors”) entered into a securities purchase agreement (the “Securities Purchase Agreement”) pursuant to which the Company agreed to sell and issue to the Investors in a private placement (the “Private Placement”) (i) an aggregate of 876,627 shares of the Company’s common stock, par value $0.01 per share, at a purchase price of $3.72 per share, and (ii) to certain investors, in lieu of shares of common stock, 1,008,102 pre-funded warrants (the “Pre-Funded Warrants”) at a price per Pre-Funded Warrant of $3.71 (the “Warrant Shares” and together with the Shares, the “Securities”). The Pre-Funded Warrants will have an exercise price of $0.01 per share of common stock, be immediately exercisable and remain exercisable until exercised in full. The Private Placement closed on March 19, 2024. The Company received gross proceeds of approximately $7.0 million, before deducting offering expenses payable by the Company. Registration Rights for Preferred and Common Offerings Pursuant to the Preferred Purchase Agreement and the Common Purchase Agreement (collectively, the “Purchase Agreements”), the Company filed a registration statement on Form S-3 (the “June 2023 Resale Registration Statement”) providing for the resale by the investors party thereto of the common stock issuable upon conversion of the Registrable Shares (as defined in the Purchase Agreements). The June 2023 Resale Registration Statement became effective on June 28, 2023. Pursuant to the Securities Purchase Agreement, the Company filed a registration statement on Form S-3 (the “April 2024 Resale Registration Statement”) providing for the resale of the common stock and common stock issuable upon the exercise of the Pre-Funded Warrants. The April 2024 Resale Registration Statement also provided for the common stock issued upon the exercise of pre-funded warrants to purchase common stock issued by the Company pursuant to the Avenue Amendment. The registration became effective on May 9, 2024. There is no established public trading market for the Series F Preferred Stock, the Preferred Warrants, Common Warrants or the Pre-Funded Warrants and the Company does not intend to list such securities on any national securities exchange or nationally recognized trading system. At-the-Market Offering The Company has entered into a Controlled Equity OfferingSM Sales Agreement (“ATM Sales Agreement”), with Cantor Fitzgerald & Co. (the “Sales Agent”), pursuant to which the Company may offer and sell, at its sole discretion through the Sales Agent, shares of common stock having an aggregate offering price of up to $17.0 million. To date, the Company has sold approximately $4.0 million of its common stock, prior to issuance costs, under the ATM Sales Agreement. No sales were made during the three months ended March 31, 2024. Authorized Shares The Company is authorized to issue 80 million shares of common stock, $0.01 par value, and 10 million shares of preferred stock, $0.01 par value. As of March 31, 2024, the Company has designated the following preferred stock:
| | | | | | | | | Designated Preferred Shares | | March 31, 2024 | Series A | | 4,200 | | Series B | | 2,360 | | Series C | | 590 | | Series D | | 10,000 | | Series E | | 40,000 | | Series E-1 | | 12,960 | | Series F-1 | | 24,900 | | Series F-2 | | 24,900 | | Series F-3 | | 34,860 | | Series F-4 | | 24,900 | | Total | | 179,670 | |
Preferred Stock As of March 31, 2024, there were an aggregate of 11,257 shares of Series E and Series E-1, 2,542 Series F-2 and 3,010 Series F-3 Convertible Preferred Stock outstanding, respectively. Omnibus Equity Incentive Plan On September 30, 2020, the Company’s 2020 Omnibus Equity Incentive Plan (the “2020 Plan”) was adopted by the Company’s Board of Directors. On November 23, 2020, the Company’s stockholders approved the 2020 Plan. The 2020 Plan will continue in effect until the tenth anniversary of the date of its adoption by the Board or until earlier terminated by the Board. The 2020 Plan is administered by the Board of Directors or a committee designated by the Board of Directors. The 2020 Plan provides for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock awards, restricted stock unit awards, performance awards, as well as other stock-based awards or cash awards that are deemed to be consistent with the purposes of the plan to Company employees, directors and consultants. As of March 31, 2024, there have been 5,125,000 shares of common stock reserved under the 2020 Plan, of which 232,566 remained available to be issued. In addition to options granted from the 2020 Plan, the Company also grants employment inducement awards pursuant to Listing Rule 5635(c)(4) of the corporate governance rules of the NASDAQ Stock Market. The inducement grants are intended to provide incentive to certain individuals to enter into employment with the Company. Prior to December 5, 2023, the inducement awards were granted outside of the 2020 Plan, however they are governed in all respects as if they were issued under the 2020 Plan. These grants do not reduce the number of options available for issuance under the 2020 Plan. On December 5, 2023, the Company’s 2023 Inducement Plan (the “2023 Plan”) was adopted by the Company’s Board of Directors. The 2023 Plan is administered by a Compensation Committee of two or more Independent Directors appointed by the Board of Directors and is intended to provide for the grant of non-qualified stock options, stock appreciation rights, restricted stock awards, restricted stock unit awards, performance awards, as well as other stock-based awards or cash awards that are deemed appropriate to incentivize employment with the Company. Awards from the 2023 Plan can only be granted to individuals who have not previously worked for the Company or have not worked for the Company for a bona fide period of time. As of March 31, 2024, there have been 650,000 shares of common stock reserved under the 2023 Plan, of which 372,000 remain available to be granted. Stock Options The following tables include information for all options granted including inducement grants that are granted outside of the 2020 Plan. The Company values stock options using the Black-Scholes option pricing model and used the following assumptions, on a weighted-average basis, during the reporting periods: | | | | | | | | | | | | | Three Months Ended March 31, | | 2024 | | 2023 | Expected terms (years) | 5.6 | | 5.8 | Expected volatility | 115.0% | | 172.8% | Risk-free interest rate | 4.19% | | 4.08% | Expected dividends | 0.00% | | 0.00% |
The following is a summary of stock option activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Number of Options | | Weighted Average Exercise Price Per Share | | Weighted Average Grant Date Fair Value Per Share | | Weighted Average Remaining Contractual Term (in years) | | Aggregate Intrinsic Value (in thousands) | Outstanding at January 1, 2024 | 4,183,232 | | $ | 8.17 | | | $ | 7.60 | | | 8.3 | | $ | 147 | | Granted | 2,017,596 | | 4.80 | | | 3.92 | | 9.7 | | | Exercised | — | | | — | | | — | | | | | — | | Expired | (15,341) | | 7.16 | | | 6.91 | | | | | Cancelled/Forfeited | (146,312) | | 6.08 | | | 5.75 | | | | | Outstanding at March 31, 2024 | 6,039,175 | | $ | 7.10 | | | $ | 6.42 | | | 8.6 | | $ | 433 | | | | | | | | | | | | Exercisable at March 31, 2024 | 2,569,497 | | $ | 9.47 | | | $ | 8.73 | | | 7.4 | | $ | 74 | | Unvested at March 31, 2024 | 3,469,678 | | | $ | 5.34 | | | $ | 4.70 | | | 9.4 | | $ | 358 | |
The following table summarizes information for stock option shares outstanding and exercisable at March 31, 2024: | | | | | | | | | | | | | | | | | | | | | | | | | Options Outstanding | Range of Exercise Prices | | Outstanding Number of Options | | Weighted Average Remaining Option Term (in years) | | Number of Options | $2.83 - $51.50 | | 6,038,676 | | 8.6 | | 6,038,676 | $51.50+ | | 499 | | 4.8 | | 499 | | | 6,039,175 | | 8.6 | | 6,039,175 |
The following is a summary of share-based compensation expense in the statement of operations for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | Three Months Ended March 31, | | | (In thousands) | 2024 | | 2023 | | | | | Selling, general and administrative | $ | 2,042 | | | $ | 1,118 | | | | | | Research and development | 647 | | | 417 | | | | | | Cost of goods sold | 256 | | | 126 | | | | | | Total | $ | 2,945 | | | $ | 1,661 | | | | | |
At March 31, 2024, there was $10.3 million of aggregate unrecognized compensation expense related employee and board stock option grants. The cost is expected to be recognized over a weighted average period of 1.2 years. Common Stock Warrants The following is a summary of common stock warrant activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | Warrants | | Weighted Average Exercise Price | | Weighted Average Remaining Life (in years) | Outstanding at January 1, 2024 | 4,665,201 | | $ | 7.76 | | | 1.6 | Warrants issued | 1,008,102 | | 0.01 | | | 5.0 | Warrants exercised | — | | | — | | | | Outstanding at March 31, 2024 | 5,673,303 | | | | 2.0 | Exercisable at March 31, 2024 | 5,673,303 | | $ | 6.39 | | | 2.0 |
The following table presents information related to common stock warrants outstanding at March 31, 2024: | | | | | | | | | | | | | | | | | | | | | Warrants Exercisable | Range of Exercise Prices | Outstanding Number of Warrants | | Weighted Average Remaining Warrant Term (in years) | | Number of Warrants | $0.01 | 2,045,894 | | 4.0 | | 2,045,894 | $6.00 | 16,666 | | 2.0 | | 16,666 | $10.00 | 3,610,743 | | 1.0 | | 3,610,743 | | 5,673,303 | | 2.0 | | 5,673,303 |
As of March 31, 2024, there were no warrants exercised for common shares. Preferred Stock Warrants The following is a summary of preferred stock warrant activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | Warrants | | Weighted Average Exercise Price | | Weighted Average Remaining Life (in years) | Outstanding at January 1, 2024 | 24,900 | | | $ | 1,000 | | | 2.3 | Warrants issued | — | | | | | | Warrants exercised | — | | | | | | Outstanding at March 31, 2024 | 24,900 | | $ | 1,000 | | | 2.0 | Exercisable at March 31, 2024 | 24,900 | | $ | 1,000 | | | 2.0 |
Employee Stock Purchase Plan In August 2021, the Company’s Board of Directors, with shareholder approval in May 2022, adopted the Employee Stock Purchase Plan (the “ESPP”). The ESPP provides for a maximum of 260,295 shares of common stock to be purchased by participating employees of which 62,575 have been issued as of March 31, 2024 since the inception of the benefit in 2021. Employees who elect to participate in the ESPP will be able to purchase common stock at the lower of 85% of the fair market value of common stock on the first or last day of the applicable six-month offering period.
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- DefinitionThe entire disclosure for equity.
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v3.24.1.1.u2
Net Loss per Share
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3 Months Ended |
Mar. 31, 2024 |
Earnings Per Share [Abstract] |
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Net Loss per Share |
Net Loss per Share Basic net loss per share is determined by dividing net loss by the weighted average shares of common stock outstanding during the period, without consideration of potentially dilutive securities, except for those shares that are issuable for little or no cash consideration. Diluted net loss per share is determined by dividing net loss by diluted weighted average shares outstanding. Diluted weighted average shares reflects the dilutive effect, if any, of potentially dilutive common shares, such as stock options and warrants calculated using the treasury stock method. In periods with reported net operating losses, all common stock options, convertible preferred shares, and preferred and common warrants are generally deemed anti-dilutive such that basic net loss per share and diluted net loss per share are equal. The following potentially dilutive securities were excluded from the computation of earnings per share as of March 31, 2024 and 2023 because their effects would be anti-dilutive: | | | | | | | | | | | | | March 31, | | 2024 | | 2023 | Common stock warrants | 3,627,409 | | 3,658,520 | Assumed conversion of preferred stock warrants | 4,149,994 | | 11,896,667 | Assumed conversion of preferred stock | 2,564,911 | | 8,681,176 | Assumed conversion of convertible notes | 488,031 | | 488,031 | Stock options | 6,039,175 | | 2,894,393 | Total | 16,869,520 | | 27,618,787 |
As of March 31, 2024 and 2023, the Company had 2,045,894 and 1,576,620 pre-funded warrants outstanding, respectively. The following table provides a reconciliation of the weighted average shares outstanding calculation for the three months ended March 31, 2024 and 2023: | | | | | | | | | | | | | | | | | Three months ended March 31, | | | | 2024 | | 2023 | | | | | Weighted average shares issued | 23,705,374 | | 10,081,634 | | | | | Weighted average pre-funded warrants | 1,181,806 | | 1,540,750 | | | | | Weighted average shares outstanding | 24,887,180 | | 11,622,384 | | | | |
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- DefinitionThe entire disclosure for earnings per share.
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v3.24.1.1.u2
Income Taxes
|
3 Months Ended |
Mar. 31, 2024 |
Income Tax Disclosure [Abstract] |
|
Income Taxes |
Income Taxes As discussed in “Note 17—Income Taxes” to the notes to the consolidated financial statements contained in the Annual Report, the Company has a valuation allowance against the full amount of its net deferred tax assets. The Company currently provides a valuation allowance against deferred tax assets when it is more likely than not that some portion or all of its deferred tax assets will not be realized. The Company has not recognized any unrecognized tax benefits in its balance sheet. The Company is subject to income tax in the U.S., as well as various state and international jurisdictions. The federal and state tax authorities can generally reduce a net operating loss (but not create taxable income) for a period outside the statute of limitations in order to determine the correct amount of net operating loss which may be allowed as a deduction against income for a period within the statute of limitations. Additional information regarding the statutes of limitations can be found in Note 17 - Income Taxes of the Company’s Annual Report. The Inflation Reduction Act of 2022 included tax legislation that became effective in the first quarter of 2023. Significant legislation for corporate taxpayers includes a corporate alternative minimum tax of 15% for companies with $1 billion or more in average net financial statement profits over the three previous years, as well as a 1% indirect excise tax on the repurchase of shares by a publicly traded company. The Company does not expect this legislation to have an effect on the tax provision as of March 31, 2024, however the Company will continue to evaluate the effect on the tax provision each reporting period.
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- DefinitionThe entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.
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v3.24.1.1.u2
Commitments and Contingencies
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3 Months Ended |
Mar. 31, 2024 |
Commitments and Contingencies Disclosure [Abstract] |
|
Commitments and Contingencies |
Commitments and Contingencies medac Matter In April 2021, the Company’s wholly owned subsidiary, Delcath Systems Ltd, issued to medac GmbH, a privately held, multi-national pharmaceutical company based in Germany (“medac”), an invoice for a €1 million milestone payment under a License, Supply and Marketing Agreement dated December 10, 2018 (the “medac Agreement”) between medac and the Company. The medac Agreement provided to medac the exclusive right to market and sell CHEMOSAT in certain designated countries for which the Company was entitled to a combination of upfront and success-based milestone payments as well as a fixed transfer price per unit of CHEMOSAT and specified royalties. In response to medac’s subsequent dispute and non-payment of the invoice, on October 12, 2021, the Company notified medac in writing that it was terminating the medac Agreement due to medac’s nonpayment of the €1 million milestone payment, with the effective date of termination of the medac Agreement being April 12, 2022. On December 16, 2021, the Company initiated an arbitration proceeding pursuant to the dispute resolution procedures of the medac Agreement for the non-payment of the invoice. On December 30, 2022, the parties reached a final settlement of the matter and the Company agreed to pay medac either (a) a royalty on sales of CHEMOSAT units over a defined minimum for a period of five years or until a maximum payment has been reached, or (b) a minimum annual payment of $0.2 million in the event the annual royalty payment does not reach the agreed minimum payment amount. The Company has estimated the fair value of the settlement to be $1.0 million as of March 31, 2024 and recorded $0.8 million as other liabilities, non-current and $0.2 million as accrued expenses on the Company’s condensed consolidated balance sheet as of March 31, 2024. Manufacturing and Supply Agreements The Company has a License, Supply and Contract Manufacturing Agreement (the “Supply Agreement”) for the supply of melphalan provided in the HEPZATO KIT. An amendment to the Supply Agreement was entered into on April 22, 2024, and effective as of May 1, 2024, which extends the term of the agreement through December 31, 2028, with an option to renew for successive five-year periods upon the mutual written consent of both parties. Although the Supply Agreement does not contain an annual minimum purchase quantity, the Agreement requires Delcath to order full lots of labeled melphalan vials. As of March 31, 2024, the Company has committed to purchasing $2.25 million of melphalan under this Supply Agreement in 2024.
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v3.24.1.1.u2
Fair Value Measurements
|
3 Months Ended |
Mar. 31, 2024 |
Fair Value Disclosures [Abstract] |
|
Fair Value Measurements |
Fair Value MeasurementsThe table below presents activity within Level 3 of the fair value hierarchy, our liabilities carried at fair value for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | Level 3 | (In thousands) | Contingent liabilities | | Warrants | | Total | Balance at January 1, 2024 | $ | 996 | | | $ | 5,548 | | | $ | 6,544 | | Total change in foreign exchange | (22) | | | — | | | (22) | | Warrant liability fair value adjustment | — | | | 612 | | | 612 | | Change due to warrant exercise | $ | — | | | $ | — | | | $ | — | | Balance at March 31, 2024 | $ | 974 | | | $ | 6,160 | | | $ | 7,134 | |
Contingent liabilities are re-measured to fair value each reporting period using projected financial targets, discount rates, probabilities of payment, and projected payment dates. Projected contingent payment amounts are discounted back to the current period using a discounted cash flow model. Projected financial targets are based on our most recent internal operational budgets and may take into consideration alternate scenarios that could result in more or less profitability for the respective service line. Increases or decreases in projected financial targets and probabilities of payment may result in significant changes in the fair value measurements. Increases in discount rates and the time to payment may result in lower fair value measurements. Increases or decreases in any of those inputs in isolation may result in a significantly lower or higher fair value measurement. As disclosed in Note 11 and Note 12 of the Company’s consolidated financial statements, the Company allocated part of the proceeds of the Series F Preferred Offering to warrant liability issued in connection with the transaction. The valuations of the warrants were determined using option pricing models. The Company concluded that the Preferred Warrants were not in the scope of Accounting Standards Codification, Distinguishing Liabilities from Equity (ASC 480) since the Preferred Warrants are not mandatorily redeemable; and do not have obligations to issue a variable number of shares of preferred stock. The Company determined the Preferred Warrants met the definition of a derivative in accordance with ASC 815 but were not considered indexed to the Company’s common stock since the warrants require early settlement by repurchasing the preferred warrants for cash in an amount equal to the Black-Scholes value in the event of a Fundamental Transaction at pre-specified volatility of 100% as an input to the Black-Scholes calculation. The Company determined to record the Preferred Warrants at fair value with subsequent changes in fair value recorded in earnings at the end of each reporting period. For the three months ended March 31, 2024, the Company recorded an increase to other expense of $0.6 million related to the change in fair value of the warrant liability. These models use inputs such as the underlying price of the shares issued at the measurement date, volatility, risk free interest rate and expected life of the instrument. The Company has classified the warrants as a long-term liability due to potential provisions relating to the holders’ ability to exercise the warrants beyond twelve months of the reporting date. The fair value of the preferred and common warrants at March 31, 2024 and December 31, 2023 was determined by using option pricing models assuming the following: | | | | | | | | | | | | | March 31, 2024 | | December 31, 2023 | Risk free interest rate | 4.49% | | 4.09% | Expected term (years) | 2.0 | | 2.3 | Expected volatility | 65% | | 70% | Expected dividends | 0.00% | | 0.00% |
Additionally, the Company has determined that the warrant liability should be classified within Level 3 of the fair-value hierarchy by evaluating each input for the option pricing models against the fair-value hierarchy criteria and using the lowest level of input as the basis for the fair-value classification as called for in ASC 820. There are six inputs: closing price of the Company’s stock on the day of evaluation; the exercise price of the warrants; the remaining term of the warrants; the volatility of the Company’s stock over that term; annual rate of dividends; and the risk-free rate of return. Of those inputs, the exercise price of the warrants and the remaining term are readily observable in the warrant agreements. The annual rate of dividends is based on the Company’s historical practice of not granting dividends. The closing price of the Company’s stock would fall under Level 1 of the fair-value hierarchy as it is a quoted price in an active market, the risk-free rate of return is a Level 2 input, while the historical volatility is a Level 3 input as defined in ASC 820-10. Since the lowest level input is a Level 3, the Company determined the warrant liability is most appropriately classified within Level 3 of the fair value hierarchy. The following tables present information about the Company’s financial assets and liabilities that have been measured at fair value as of March 31, 2024 and December 31, 2023 and indicate the fair value hierarchy of the valuation inputs utilized to determine such fair value. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | March 31, 2024 | (In thousands) | | Quoted Prices in Active Markets (Level 1) | | Significant Other Observable Inputs (Level 2) | | Significant Unobservable Inputs (Level 3) | | Total | Assets: | | | | | | | | | Money market funds | | $ | 72 | | | $ | — | | | $ | — | | | $ | 72 | | U.S. government agency bonds | | — | | | 15,360 | | | — | | | 15,360 | | Total Assets | | $ | 72 | | | $ | 15,360 | | | $ | — | | | $ | 15,432 | | | | | | | | | | | Liabilities: | | | | | | | | | Contingent Liability | | $ | — | | | $ | — | | | $ | 974 | | | $ | 974 | | Warrant Liabilities | | — | | | — | | | 6,160 | | | 6,160 | | Total Liabilities | | $ | — | | | $ | — | | | $ | 7,134 | | | $ | 7,134 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | December 31, 2023 | (In thousands) | | Quoted Prices in Active Markets (Level 1) | | Significant Other Observable Inputs (Level 2) | | Significant Unobservable Inputs (Level 3) | | Total | Assets: | | | | | | | | | Money market funds | | $ | 392 | | | $ | — | | | $ | — | | | $ | 392 | | U.S. government agency bonds | | — | | | 19,808 | | | — | | | 19,808 | | Total Assets | | $ | 392 | | | $ | 19,808 | | | $ | — | | | $ | 20,200 | | | | | | | | | | | Liabilities: | | | | | | | | | Contingent Liability | | $ | — | | | $ | — | | | $ | 996 | | | $ | 996 | | Warrant Liabilities | | — | | | — | | | 5,548 | | | 5,548 | | Total Liabilities | | $ | — | | | $ | — | | | $ | 6,544 | | | $ | 6,544 | |
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v3.24.1.1.u2
General (Policies)
|
3 Months Ended |
Mar. 31, 2024 |
Accounting Policies [Abstract] |
|
Risks and Uncertainties |
Risks and Uncertainties As detailed in the Company’s 2023 Annual Report filed on Form 10-K, the Company is subject to risks common to companies in the biopharmaceutical industry with FDA-approved products and planned clinical development activities, including, but not limited to, risks associated with successfully launching and commercializing the products; further developing HEPZATO to potentially treat other cancers in the liver and the Company’s ability to obtain any additional regulatory approval of such products in the United States and obtaining regulatory approval in other geographic markets; the uncertainty relating to the broad adoption of any approved products by physicians and consumers; and the impacts of significant competition. In addition, high rates of inflation have resulted in the U.S. Federal Reserve raising interest rates. Increases in interest rates, especially if coupled with reduced government spending and volatility in financial markets, may further increase economic uncertainty and heighten these risks. Furthermore, if additional banks and financial institutions enter receivership or become insolvent in the future in response to financial conditions affecting the banking system and financial markets, the Company or its partners’ ability to access existing cash, cash equivalents and investments may be threatened and could have a material adverse effect on the Company’s business and financial condition, including the Company’s ability to access additional capital on favorable terms, or at all, which could in the future negatively affect the Company’s ability to pursue its business strategy.
|
Liquidity and Going Concern |
Liquidity and Going Concern On March 31, 2024, the Company had cash, cash equivalents and restricted cash totaling $11.8 million and short-term investments totaling $15.4 million, as compared to cash, cash equivalents and restricted cash totaling $12.7 million and short-term investments totaling $19.8 million at December 31, 2023. During the three months ended March 31, 2024, the Company used $9.6 million of cash in its operating activities and $3.1 million for principal payments. The Company’s future results are subject to substantial risks and uncertainties. The Company has operated at a loss for its entire history and there can be no assurance that it will ever achieve or maintain profitability. The Company has historically funded its operations primarily with proceeds from sales of common stock, warrants and pre-funded warrants for the purchase of common stock, sales of preferred stock, proceeds from the issuance of convertible debt and borrowings under loan and security agreements. If there is a substantial delay in the activation of sites to administer HEPZATO, the Company expects to need to raise additional capital under structures available to the Company, including debt and/or equity offerings, which may not be on favorable terms. In a substantially delayed site activation scenario, the Company would not have sufficient funds to meet its obligations within twelve months from the issuance date of these condensed consolidated financial statements. As such, there is uncertainty regarding the Company’s ability to maintain liquidity sufficient to operate its business effectively, which raises substantial doubt about the Company’s ability to continue as a going concern. Debt financing and equity financing, if available, may involve agreements that include covenants limiting or restricting the Company’s ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If the Company raises funds through collaborations or other similar arrangements with third parties, it may have to relinquish valuable rights to its technologies, future revenue streams, research programs for product candidates and/or grant licenses on terms that may not be favorable to the Company, any of which may reduce the value of its common stock. If the Company is unable to raise additional funds through equity or debt financings when needed, it may be required to delay, limit, reduce or terminate its product development or future commercialization efforts or grant rights to develop and market its product candidates to third parties even if the Company would otherwise prefer to develop and market such product candidates itself. The Company also expects to use cash and cash equivalents to fund activities relating to commercial support for HEPZATO, CHEMOSAT and any future clinical research trials and operating activities. The Company’s future liquidity and capital requirements will depend on numerous factors, including the initiation and progress of clinical trials and research and product development programs; obtaining regulatory approvals and complying with applicable laws and regulations; the timing and effectiveness of product commercialization activities, including marketing arrangements; the timing and costs involved in preparing, filing, prosecuting, defending and enforcing intellectual property rights; the resolution of any disputes with third parties; and the effect of competing technological and market developments. The Company’s capital commitments over the next twelve months include (a) $6.0 million to satisfy accounts payable, accrued expenses, current lease liabilities and current medac settlement and (b) $7.6 million of loan and convertible note principal payments, if the holders do not elect to convert up to $5.0 million of the notes into equity. Additional capital commitments beyond the next twelve months include (a) $1.0 million of lease liabilities; and (b) $0.8 million for settlement of litigation with medac.
|
Basis of Presentation |
Basis of Presentation These interim condensed consolidated financial statements are unaudited and were prepared by the Company in accordance with generally accepted accounting principles in the United States of America (GAAP) and with the SEC’s instructions to Form 10-Q and Article 10 of Regulation S-X. They include the accounts of all wholly owned subsidiaries and all significant inter-company accounts and transactions have been eliminated in consolidation. The preparation of interim condensed consolidated financial statements requires management to make assumptions and estimates that impact the amounts reported. These interim condensed consolidated financial statements reflect all adjustments, consisting of normal recurring accruals, necessary for a fair presentation of the Company’s results of operations, financial position and cash flows for the interim periods ended March 31, 2024 and 2023; however, certain information and footnote disclosures normally included in our audited consolidated financial statements which were included in our Annual Report have been condensed or omitted as permitted by GAAP. It is important to note that the Company’s results of operations and cash flows for interim periods are not necessarily indicative of the results of operations and cash flows to be expected for a full fiscal year or any interim period.
|
Recent Accounting Pronouncements |
Recent Accounting Pronouncements No new accounting standards were adopted during the three months ended March 31, 2024
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v3.24.1.1.u2
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- DefinitionTabular disclosure of disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor.
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v3.24.1.1.u2
Cash, Cash Equivalents and Restricted Cash (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Cash and Cash Equivalents [Abstract] |
|
Schedule of Cash, Cash Equivalents, and Restricted Cash |
Cash, cash equivalents, and restricted cash balances were as follows: | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | Cash and cash equivalents | $ | 11,760 | | | $ | 12,646 | | Security for credit cards | 50 | | | 50 | | Total cash, cash equivalents and restricted cash shown in the statements of cash flows | $ | 11,810 | | | $ | 12,696 | |
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v3.24.1.1.u2
Investments (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Schedule of Unrealized Gains and Losses |
The following table summarizes the gross unrealized gains on the Company’s marketable securities as of March 31, 2024:
| | | | | | | | | | | | | | | | | | | | | | | March 31, 2024 | | | | | Gross Unrealized | | | (In thousands) | | Amortized Cost | | Gains | | Estimated Fair Value | U.S. government agency bonds | | $ | 15,195 | | | $ | 165 | | | $ | 15,360 | | | | $ | 15,195 | | | $ | 165 | | | $ | 15,360 | | Short-term investments | | | | | | $ | 15,360 | |
The following table summarizes the gross unrealized gains on the Company’s marketable securities as of December 31, 2023: | | | | | | | | | | | | | | | | | | | | | | | December 31, 2023 | | | | | Gross Unrealized | | | (in thousands) | | Amortized Cost | | Gains | | Estimated Fair Value | U.S. government agency bonds | | $ | 19,651 | | | $ | 157 | | | $ | 19,808 | | | | $ | 19,651 | | | $ | 157 | | | $ | 19,808 | | Short-term investments | | | | | | $ | 19,808 | | | | | | | | |
|
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v3.24.1.1.u2
Inventory (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Inventory Disclosure [Abstract] |
|
Schedule of Inventory |
Inventory consists of the following: | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | Raw materials | $ | 1,335 | | | $ | 1,443 | | Work-in-process | 1,983 | | | 1,753 | | Finished goods | 316 | | | 126 | | Total inventory | $ | 3,634 | | | $ | 3,322 | |
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v3.24.1.1.u2
Property, Plant, and Equipment (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Property, Plant and Equipment [Abstract] |
|
Components of Property, Plant and Equipment |
Property, plant, and equipment consist of the following: | | | | | | | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | | Estimated Useful Life | Buildings and land | $ | 1,318 | | | $ | 1,318 | | | 30 years - Buildings | Enterprise hardware and software | 1,857 | | | 1,857 | | | 3 years | Leaseholds | 1,779 | | | 1,787 | | | Lesser of lease term or estimated useful life | Equipment | 1,262 | | | 1,263 | | | 7 years | Furniture | 215 | | | 202 | | | 5 years | Property, plant and equipment, gross | 6,431 | | | 6,427 | | | | Accumulated depreciation | (5,095) | | | (5,075) | | | | Property, plant and equipment, net | $ | 1,336 | | | $ | 1,352 | | | |
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v3.24.1.1.u2
Accrued Expenses (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Payables and Accruals [Abstract] |
|
Schedule of Accrued Expenses |
Accrued expenses consist of the following: | | | | | | | | | | | | (In thousands) | March 31, 2024 | | December 31, 2023 | Clinical expenses | $ | 1,064 | | | $ | 1,129 | | Compensation, excluding taxes | 1,567 | | | 1,859 | | Professional fees | 252 | | | 272 | | Interest on convertible note | 753 | | | 713 | | Inventory | 12 | | | 585 | | Other | 747 | | | 691 | | Total accrued expenses | $ | 4,395 | | | $ | 5,249 | |
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v3.24.1.1.u2
Leases (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Leases [Abstract] |
|
Schedule of Lease Costs |
The following table summarizes the Company’s operating leases as of March 31, 2024: | | | | | | | | | | | | | | | | | | (In thousands) | U.S. | | Ireland | | Total | Operating cash flows for operating leases | $ | 4 | | | $ | 9 | | | $ | 13 | | Weighted average remaining lease term | 9.8 | | 2.3 | | | Weighted average discount rate - operating leases | 8 | % | | 8 | % | | |
|
Schedule of Remaining maturity of Operating Leases Excluding Short-Term Leases |
Remaining maturities of the Company’s operating leases, excluding short-term leases, are as follows: | | | | | | | | | | | | | | | | | | (In thousands) | U.S. | | Ireland | | Total | Year ended December 31, 2024 | $ | 108 | | | $ | 32 | | | $ | 140 | | Year ended December 31, 2025 | 144 | | | 43 | | | 187 | | Year ended December 31, 2026 | 144 | | | 25 | | | 169 | | Year ended December 31, 2027 | 148 | | | — | | | 148 | | Year ended December 31, 2028 | 153 | | | — | | | 153 | | Thereafter | 800 | | | — | | | 800 | | Total | 1,497 | | | 100 | | | 1,597 | | Less present value discount | (471) | | | (8) | | | (479) | | Operating lease liabilities included in the condensed consolidated balance sheets at March 31, 2024 | $ | 1,026 | | | $ | 92 | | | $ | 1,118 | |
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v3.24.1.1.u2
Loans and Convertible Notes Payable (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Debt Disclosure [Abstract] |
|
Summary of Loans and Convertible Notes Payable |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | March 31, 2024 | | December 31, 2023 | (In thousands) | Gross | | Discount | | Net | | Gross | | Discount | | Net | Loans payable, current1 | $ | 2,557 | | | $ | (149) | | | $ | 2,408 | | | $ | 5,610 | | | $ | (371) | | | $ | 5,239 | | Convertible notes payable - current | 5,000 | | | (51) | | | 4,949 | | | 5,000 | | | (89) | | | 4,911 | | Total - Loans and notes payable | $ | 7,557 | | | $ | (200) | | | $ | 7,357 | | | $ | 10,610 | | | $ | (460) | | | $ | 10,150 | |
1 The gross amount includes the 4.25% final payment of $0.5 million.
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v3.24.1.1.u2
Stockholders' Equity (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Stockholders' Equity Note [Abstract] |
|
Schedule of Designated Preferred Units |
As of March 31, 2024, the Company has designated the following preferred stock: | | | | | | | | | Designated Preferred Shares | | March 31, 2024 | Series A | | 4,200 | | Series B | | 2,360 | | Series C | | 590 | | Series D | | 10,000 | | Series E | | 40,000 | | Series E-1 | | 12,960 | | Series F-1 | | 24,900 | | Series F-2 | | 24,900 | | Series F-3 | | 34,860 | | Series F-4 | | 24,900 | | Total | | 179,670 | |
|
Summary of Avenue Warrant Valued Using the Black-Scholes Option Pricing Method |
The Company values stock options using the Black-Scholes option pricing model and used the following assumptions, on a weighted-average basis, during the reporting periods: | | | | | | | | | | | | | Three Months Ended March 31, | | 2024 | | 2023 | Expected terms (years) | 5.6 | | 5.8 | Expected volatility | 115.0% | | 172.8% | Risk-free interest rate | 4.19% | | 4.08% | Expected dividends | 0.00% | | 0.00% |
|
Summary of Stock Option Activity |
The following is a summary of stock option activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Number of Options | | Weighted Average Exercise Price Per Share | | Weighted Average Grant Date Fair Value Per Share | | Weighted Average Remaining Contractual Term (in years) | | Aggregate Intrinsic Value (in thousands) | Outstanding at January 1, 2024 | 4,183,232 | | $ | 8.17 | | | $ | 7.60 | | | 8.3 | | $ | 147 | | Granted | 2,017,596 | | 4.80 | | | 3.92 | | 9.7 | | | Exercised | — | | | — | | | — | | | | | — | | Expired | (15,341) | | 7.16 | | | 6.91 | | | | | Cancelled/Forfeited | (146,312) | | 6.08 | | | 5.75 | | | | | Outstanding at March 31, 2024 | 6,039,175 | | $ | 7.10 | | | $ | 6.42 | | | 8.6 | | $ | 433 | | | | | | | | | | | | Exercisable at March 31, 2024 | 2,569,497 | | $ | 9.47 | | | $ | 8.73 | | | 7.4 | | $ | 74 | | Unvested at March 31, 2024 | 3,469,678 | | | $ | 5.34 | | | $ | 4.70 | | | 9.4 | | $ | 358 | |
|
Summary of Stock Option Shares Outstanding and Exercisable |
The following table summarizes information for stock option shares outstanding and exercisable at March 31, 2024: | | | | | | | | | | | | | | | | | | | | | | | | | Options Outstanding | Range of Exercise Prices | | Outstanding Number of Options | | Weighted Average Remaining Option Term (in years) | | Number of Options | $2.83 - $51.50 | | 6,038,676 | | 8.6 | | 6,038,676 | $51.50+ | | 499 | | 4.8 | | 499 | | | 6,039,175 | | 8.6 | | 6,039,175 |
|
Summary of Recognized Share-based Compensation Cost |
The following is a summary of share-based compensation expense in the statement of operations for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | Three Months Ended March 31, | | | (In thousands) | 2024 | | 2023 | | | | | Selling, general and administrative | $ | 2,042 | | | $ | 1,118 | | | | | | Research and development | 647 | | | 417 | | | | | | Cost of goods sold | 256 | | | 126 | | | | | | Total | $ | 2,945 | | | $ | 1,661 | | | | | |
|
Summary of Warrant Activity |
The following is a summary of common stock warrant activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | Warrants | | Weighted Average Exercise Price | | Weighted Average Remaining Life (in years) | Outstanding at January 1, 2024 | 4,665,201 | | $ | 7.76 | | | 1.6 | Warrants issued | 1,008,102 | | 0.01 | | | 5.0 | Warrants exercised | — | | | — | | | | Outstanding at March 31, 2024 | 5,673,303 | | | | 2.0 | Exercisable at March 31, 2024 | 5,673,303 | | $ | 6.39 | | | 2.0 |
The following is a summary of preferred stock warrant activity for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | Warrants | | Weighted Average Exercise Price | | Weighted Average Remaining Life (in years) | Outstanding at January 1, 2024 | 24,900 | | | $ | 1,000 | | | 2.3 | Warrants issued | — | | | | | | Warrants exercised | — | | | | | | Outstanding at March 31, 2024 | 24,900 | | $ | 1,000 | | | 2.0 | Exercisable at March 31, 2024 | 24,900 | | $ | 1,000 | | | 2.0 |
|
Schedule of Information Related to Stock Warrants Outstanding and Exercisable |
The following table presents information related to common stock warrants outstanding at March 31, 2024: | | | | | | | | | | | | | | | | | | | | | Warrants Exercisable | Range of Exercise Prices | Outstanding Number of Warrants | | Weighted Average Remaining Warrant Term (in years) | | Number of Warrants | $0.01 | 2,045,894 | | 4.0 | | 2,045,894 | $6.00 | 16,666 | | 2.0 | | 16,666 | $10.00 | 3,610,743 | | 1.0 | | 3,610,743 | | 5,673,303 | | 2.0 | | 5,673,303 |
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v3.24.1.1.u2
Net Loss per Share (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Earnings Per Share [Abstract] |
|
Antidilutive Securities Excluded from the Computation of Earnings Per Share |
The following potentially dilutive securities were excluded from the computation of earnings per share as of March 31, 2024 and 2023 because their effects would be anti-dilutive: | | | | | | | | | | | | | March 31, | | 2024 | | 2023 | Common stock warrants | 3,627,409 | | 3,658,520 | Assumed conversion of preferred stock warrants | 4,149,994 | | 11,896,667 | Assumed conversion of preferred stock | 2,564,911 | | 8,681,176 | Assumed conversion of convertible notes | 488,031 | | 488,031 | Stock options | 6,039,175 | | 2,894,393 | Total | 16,869,520 | | 27,618,787 |
|
Summary of Reconciliation of Weighted Average Shares Outstanding Calculation |
The following table provides a reconciliation of the weighted average shares outstanding calculation for the three months ended March 31, 2024 and 2023: | | | | | | | | | | | | | | | | | Three months ended March 31, | | | | 2024 | | 2023 | | | | | Weighted average shares issued | 23,705,374 | | 10,081,634 | | | | | Weighted average pre-funded warrants | 1,181,806 | | 1,540,750 | | | | | Weighted average shares outstanding | 24,887,180 | | 11,622,384 | | | | |
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v3.24.1.1.u2
Fair Value Measurements (Tables)
|
3 Months Ended |
Mar. 31, 2024 |
Fair Value Disclosures [Abstract] |
|
Schedule of Level 3 Investments |
The table below presents activity within Level 3 of the fair value hierarchy, our liabilities carried at fair value for the three months ended March 31, 2024: | | | | | | | | | | | | | | | | | | | Level 3 | (In thousands) | Contingent liabilities | | Warrants | | Total | Balance at January 1, 2024 | $ | 996 | | | $ | 5,548 | | | $ | 6,544 | | Total change in foreign exchange | (22) | | | — | | | (22) | | Warrant liability fair value adjustment | — | | | 612 | | | 612 | | Change due to warrant exercise | $ | — | | | $ | — | | | $ | — | | Balance at March 31, 2024 | $ | 974 | | | $ | 6,160 | | | $ | 7,134 | |
|
Schedule of Fair Value Assumptions for Warrants |
The fair value of the preferred and common warrants at March 31, 2024 and December 31, 2023 was determined by using option pricing models assuming the following: | | | | | | | | | | | | | March 31, 2024 | | December 31, 2023 | Risk free interest rate | 4.49% | | 4.09% | Expected term (years) | 2.0 | | 2.3 | Expected volatility | 65% | | 70% | Expected dividends | 0.00% | | 0.00% |
|
Schedule of Financial Assets Carried at Fair Value |
The following tables present information about the Company’s financial assets and liabilities that have been measured at fair value as of March 31, 2024 and December 31, 2023 and indicate the fair value hierarchy of the valuation inputs utilized to determine such fair value. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | March 31, 2024 | (In thousands) | | Quoted Prices in Active Markets (Level 1) | | Significant Other Observable Inputs (Level 2) | | Significant Unobservable Inputs (Level 3) | | Total | Assets: | | | | | | | | | Money market funds | | $ | 72 | | | $ | — | | | $ | — | | | $ | 72 | | U.S. government agency bonds | | — | | | 15,360 | | | — | | | 15,360 | | Total Assets | | $ | 72 | | | $ | 15,360 | | | $ | — | | | $ | 15,432 | | | | | | | | | | | Liabilities: | | | | | | | | | Contingent Liability | | $ | — | | | $ | — | | | $ | 974 | | | $ | 974 | | Warrant Liabilities | | — | | | — | | | 6,160 | | | 6,160 | | Total Liabilities | | $ | — | | | $ | — | | | $ | 7,134 | | | $ | 7,134 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | December 31, 2023 | (In thousands) | | Quoted Prices in Active Markets (Level 1) | | Significant Other Observable Inputs (Level 2) | | Significant Unobservable Inputs (Level 3) | | Total | Assets: | | | | | | | | | Money market funds | | $ | 392 | | | $ | — | | | $ | — | | | $ | 392 | | U.S. government agency bonds | | — | | | 19,808 | | | — | | | 19,808 | | Total Assets | | $ | 392 | | | $ | 19,808 | | | $ | — | | | $ | 20,200 | | | | | | | | | | | Liabilities: | | | | | | | | | Contingent Liability | | $ | — | | | $ | — | | | $ | 996 | | | $ | 996 | | Warrant Liabilities | | — | | | — | | | 5,548 | | | 5,548 | | Total Liabilities | | $ | — | | | $ | — | | | $ | 6,544 | | | $ | 6,544 | |
|
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v3.24.1.1.u2
General (Details) - USD ($) $ in Thousands |
3 Months Ended |
|
Mar. 31, 2024 |
Mar. 31, 2023 |
Dec. 31, 2023 |
Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Line Items] |
|
|
|
Cash cash equivalents and restricted cash |
$ 11,800
|
|
$ 12,700
|
Short-term investments |
15,360
|
|
$ 19,808
|
Net cash used in operating activities |
9,584
|
$ 4,264
|
|
Principal payments |
3,054
|
$ 6,313
|
|
Accounts payable, accrued expenses, current lease liabilities and current medac settlement |
|
|
|
Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Line Items] |
|
|
|
Current capital commitments |
6,000
|
|
|
Loan and convertible note principal payments |
|
|
|
Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Line Items] |
|
|
|
Current capital commitments |
7,600
|
|
|
Conversion of notes to equity |
|
|
|
Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Line Items] |
|
|
|
Noncurrent capital commitments |
5,000
|
|
|
Lease liabilities |
|
|
|
Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Line Items] |
|
|
|
Noncurrent capital commitments |
1,000
|
|
|
Settlement of litigation with medac |
|
|
|
Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Line Items] |
|
|
|
Noncurrent capital commitments |
$ 800
|
|
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Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands |
Mar. 31, 2024 |
Dec. 31, 2023 |
Mar. 31, 2023 |
Dec. 31, 2022 |
Cash and Cash Equivalents [Abstract] |
|
|
|
|
Cash and cash equivalents |
$ 11,760
|
$ 12,646
|
|
|
Security for credit cards |
50
|
50
|
|
|
Total cash, cash equivalents and restricted cash shown in the statements of cash flows |
$ 11,810
|
$ 12,696
|
$ 24,272
|
$ 11,822
|
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Investments (Details) - USD ($) $ in Thousands |
Mar. 31, 2024 |
Dec. 31, 2023 |
Debt Securities, Available-for-sale [Line Items] |
|
|
Amortized Cost |
$ 15,195
|
$ 19,651
|
Gross Unrealized Gains |
165
|
157
|
Estimated Fair Value |
15,360
|
19,808
|
Interest Receivable |
164
|
151
|
U.S. government agency bonds |
|
|
Debt Securities, Available-for-sale [Line Items] |
|
|
Amortized Cost |
15,195
|
19,651
|
Gross Unrealized Gains |
165
|
157
|
Estimated Fair Value |
$ 15,360
|
$ 19,808
|
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Property, Plant, and Equipment (Details) - USD ($) $ in Thousands |
Mar. 31, 2024 |
Dec. 31, 2023 |
Property Plant And Equipment [Line Items] |
|
|
Property, plant and equipment, gross |
$ 6,431
|
$ 6,427
|
Accumulated depreciation |
(5,095)
|
(5,075)
|
Property, plant and equipment, net |
1,336
|
1,352
|
Buildings and land |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property, plant and equipment, gross |
$ 1,318
|
1,318
|
Buildings |
|
|
Property Plant And Equipment [Line Items] |
|
|
Estimated Useful Life |
30 years
|
|
Enterprise hardware and software |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property, plant and equipment, gross |
$ 1,857
|
1,857
|
Estimated Useful Life |
3 years
|
|
Leaseholds |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property, plant and equipment, gross |
$ 1,779
|
1,787
|
Equipment |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property, plant and equipment, gross |
$ 1,262
|
1,263
|
Estimated Useful Life |
7 years
|
|
Furniture |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property, plant and equipment, gross |
$ 215
|
$ 202
|
Estimated Useful Life |
5 years
|
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v3.24.1.1.u2
Leases - Schedule of Remaining Maturity of Operating Leases Excluding Short-Term Leases (Details) $ in Thousands |
Mar. 31, 2024
USD ($)
|
Lessee Lease Description [Line Items] |
|
Year ended December 31, 2024 |
$ 140
|
Year ended December 31, 2025 |
187
|
Year ended December 31, 2026 |
169
|
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148
|
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153
|
Thereafter |
800
|
Total |
1,597
|
Less present value discount |
(479)
|
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1,118
|
U.S. |
|
Lessee Lease Description [Line Items] |
|
Year ended December 31, 2024 |
108
|
Year ended December 31, 2025 |
144
|
Year ended December 31, 2026 |
144
|
Year ended December 31, 2027 |
148
|
Year ended December 31, 2028 |
153
|
Thereafter |
800
|
Total |
1,497
|
Less present value discount |
(471)
|
Operating lease liabilities included in the condensed consolidated balance sheets at March 31, 2024 |
1,026
|
Ireland |
|
Lessee Lease Description [Line Items] |
|
Year ended December 31, 2024 |
32
|
Year ended December 31, 2025 |
43
|
Year ended December 31, 2026 |
25
|
Year ended December 31, 2027 |
0
|
Year ended December 31, 2028 |
0
|
Thereafter |
0
|
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100
|
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(8)
|
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v3.24.1.1.u2
Loans and Convertible Notes Payable - Summary of Loans and Convertible Notes Payable (Details) - USD ($) $ in Thousands |
3 Months Ended |
|
Mar. 31, 2024 |
Dec. 31, 2023 |
Debt Instrument [Line Items] |
|
|
Loans and notes payable, gross |
$ 7,557
|
$ 10,610
|
Discount |
(200)
|
(460)
|
Total - Loans and notes payable |
$ 7,357
|
10,150
|
Percentage of final payment included in gross amount |
4.25%
|
|
Final payment |
$ 500
|
|
Loans Payable |
|
|
Debt Instrument [Line Items] |
|
|
Loans and notes payable, current, gross |
2,557
|
5,610
|
Discount, current |
(149)
|
(371)
|
Loans and notes payable, current, net |
2,408
|
5,239
|
Convertible Notes Payable |
|
|
Debt Instrument [Line Items] |
|
|
Loans and notes payable, current, gross |
5,000
|
5,000
|
Discount, current |
(51)
|
(89)
|
Loans and notes payable, current, net |
$ 4,949
|
$ 4,911
|
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v3.24.1.1.u2
Loans and Convertible Notes Payable - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands |
|
|
|
|
1 Months Ended |
3 Months Ended |
Aug. 14, 2023 |
Mar. 31, 2023 |
Mar. 15, 2023 |
Aug. 06, 2021 |
Apr. 30, 2024 |
Jan. 31, 2024 |
Mar. 31, 2024 |
Mar. 31, 2023 |
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
Restricted cash |
|
$ 50
|
|
|
|
|
$ 50
|
$ 50
|
Principal payments |
|
|
|
|
|
|
3,054
|
6,313
|
Final payment |
|
|
|
|
|
|
500
|
|
Proceeds from exercise of warrants |
|
|
|
|
|
|
$ 0
|
$ 0
|
Warrants issued to purchase of common stock (in shares) |
|
|
|
127,755
|
|
|
|
|
Warrant exercise price (in dollars per share) |
|
$ 0.01
|
|
$ 0.01
|
|
|
|
$ 0.01
|
Number of warrants outstanding (in shares) |
|
34,072
|
|
|
|
|
|
34,072
|
Subsequent Event |
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
Warrants exercised (in shares) |
|
|
|
|
34,072
|
|
|
|
Preferred Tranche A Warrant |
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
Proceeds from exercise of warrants |
$ 10,000
|
|
|
|
|
|
|
|
Series E |
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
Debt instrument, conversion price (in dollars per share) |
|
|
|
$ 1,198
|
|
|
$ 1,500
|
|
Avenue Loan |
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
Debt instrument, principal face amount |
|
|
|
$ 20,000
|
|
|
|
|
Interest rate |
|
|
|
7.70%
|
|
|
|
|
Debt instrument, interest rate |
|
|
|
10.95%
|
|
|
16.20%
|
|
Initial tranche of loan |
|
|
|
$ 15,000
|
|
|
|
|
Loan amount funded into restricted account |
|
|
|
4,000
|
|
|
|
|
Restricted cash |
|
|
$ 4,000
|
|
|
|
|
|
Principal payments |
|
|
$ 2,100
|
|
|
|
|
|
Debt instrument, incremental final payment, percentage |
|
|
4.25%
|
|
|
|
|
|
Final payment |
|
|
$ 200
|
|
|
|
|
|
Estimated minimum proceeds on issue of common stock for extension of due date of interest only interest payments |
|
$ 10,000
|
|
|
|
|
|
|
Principal payments |
|
|
|
|
|
$ 1,000
|
|
|
Principal amount hat may be converted to common stock |
|
|
|
$ 3,000
|
|
|
|
|
Debt instrument, conversion price (in dollars per share) |
|
|
|
$ 11.98
|
|
|
|
|
Amortization of debt discount |
|
|
|
|
|
|
$ 300
|
$ 200
|
Interest expense incurred |
|
|
|
|
|
|
300
|
500
|
Rosalind Notes |
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
Debt instrument, principal face amount |
|
|
|
|
|
|
$ 2,000
|
|
Interest rate |
|
|
|
|
|
|
8.00%
|
|
Interest expense incurred |
|
|
|
|
|
|
$ 100
|
$ 100
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v3.24.1.1.u2
Preferred Purchase Agreement (Details) - USD ($) $ / shares in Units, $ in Thousands |
|
3 Months Ended |
|
|
Mar. 29, 2023 |
Mar. 31, 2024 |
Dec. 31, 2023 |
Mar. 31, 2023 |
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
|
$ 0.01
|
$ 0.01
|
$ 0.01
|
Fair value of warrant liabilities |
|
$ 7,134
|
$ 6,544
|
|
Deferred revenue |
$ 10,000
|
$ 10,000
|
|
|
Preferred stock, shares outstanding (in shares) |
|
16,809
|
24,819
|
|
Preferred Warrant Liabilities |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Proceeds from issuance of warrants |
24,900
|
|
|
|
Fair value of warrant liabilities |
$ 4,900
|
|
|
|
Preferred Purchase Agreement | Series F-1 |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Number of exercisable preferred warrants (in shares) |
24,900
|
|
|
|
Preferred Purchase Agreement | Preferred Tranche A Warrant |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Aggregate exercise price of preferred warrants |
|
$ 34,900
|
|
|
Preferred Purchase Agreement | Preferred Tranche B Warrant |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Number of exercisable preferred warrants (in shares) |
24,900
|
|
|
|
Aggregate exercise price of preferred warrants |
|
$ 24,900
|
|
|
Warrant exercise period |
|
21 days
|
|
|
Preferred Purchase Agreement | Series F-4 |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Number of exercisable preferred warrants (in shares) |
|
24,900
|
|
|
Series F1, Series F2 and F3 Preferred Stock |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Conversion of shares (in shares) |
|
54,207
|
|
|
Series F-1 | Preferred Warrant Liabilities |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Proceeds from issuance of warrants |
$ 20,000
|
|
|
|
Series F-1 | Preferred Purchase Agreement |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
$ 0.01
|
|
|
|
Series F-2 |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
|
$ 3.30
|
|
|
Preferred stock, shares outstanding (in shares) |
|
2,542
|
|
|
Series F-2 | Preferred Purchase Agreement |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
|
$ 0.01
|
|
|
Series F-3 |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
|
$ 4.50
|
|
|
Preferred stock, shares outstanding (in shares) |
|
3,010
|
|
|
Series F-3 | Preferred Tranche A Warrant |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Number of exercisable preferred warrants (in shares) |
34,859
|
|
|
|
Series F-3 | Preferred Purchase Agreement |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
$ 0.01
|
|
|
|
Common Stock |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Number of shares converted (in shares) |
|
13,853,143
|
|
|
Series F-4 |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
|
$ 6.00
|
|
|
Preferred stock, shares outstanding (in shares) |
|
0
|
|
|
Series F-4 | Preferred Purchase Agreement |
|
|
|
|
Disclosure Of Preferred Purchase Agreement [Line Items] |
|
|
|
|
Preferred stock, par value (in dollars per share) |
$ 0.01
|
|
|
|
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Stockholders' Equity - Securities Purchase Agreement (Details) - USD ($) $ / shares in Units, $ in Thousands |
|
|
|
3 Months Ended |
|
Mar. 19, 2024 |
Mar. 14, 2024 |
Aug. 06, 2021 |
Mar. 31, 2024 |
Mar. 31, 2023 |
Dec. 31, 2023 |
Stockholders Equity Note [Line Items] |
|
|
|
|
|
|
Common stock, par value (in dollars per share) |
|
|
|
$ 0.01
|
$ 0.01
|
$ 0.01
|
Warrants issued to purchase of common stock (in shares) |
|
|
127,755
|
|
|
|
Warrant exercise price (in dollars per share) |
|
|
$ 0.01
|
|
$ 0.01
|
|
Proceeds from private placement |
|
|
|
$ 7,000
|
$ 22,960
|
|
PreFundedWarrants |
|
|
|
|
|
|
Stockholders Equity Note [Line Items] |
|
|
|
|
|
|
Warrants issued to purchase of common stock (in shares) |
|
1,008,102
|
|
|
|
|
Private Placement |
|
|
|
|
|
|
Stockholders Equity Note [Line Items] |
|
|
|
|
|
|
Proceeds from private placement |
$ 7,000
|
|
|
|
|
|
Private Placement | PreFundedWarrants |
|
|
|
|
|
|
Stockholders Equity Note [Line Items] |
|
|
|
|
|
|
Warrants issued to purchase of common stock, price per warrant (in dollars per share) |
|
$ 3.71
|
|
|
|
|
Warrant exercise price (in dollars per share) |
|
$ 0.01
|
|
|
|
|
Common Stock | Private Placement |
|
|
|
|
|
|
Stockholders Equity Note [Line Items] |
|
|
|
|
|
|
Stock issued during period, shares, new issues (in shares) |
|
876,627
|
|
|
|
|
Common stock, par value (in dollars per share) |
|
$ 0.01
|
|
|
|
|
Shares issued, price per share (in dollars per share) |
|
$ 3.72
|
|
|
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v3.24.1.1.u2
Stockholders' Equity - Designated Preferred Shares (Details)
|
Mar. 31, 2024
shares
|
Class of Stock [Line Items] |
|
Preferred stock, shares designated (in shares) |
179,670
|
Series A |
|
Class of Stock [Line Items] |
|
Preferred stock, shares designated (in shares) |
4,200
|
Series B |
|
Class of Stock [Line Items] |
|
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2,360
|
Series C |
|
Class of Stock [Line Items] |
|
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590
|
Series D |
|
Class of Stock [Line Items] |
|
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10,000
|
Series E |
|
Class of Stock [Line Items] |
|
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40,000
|
Series E-1 |
|
Class of Stock [Line Items] |
|
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12,960
|
Series F-1 |
|
Class of Stock [Line Items] |
|
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24,900
|
Series F-2 |
|
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|
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24,900
|
Series F-3 |
|
Class of Stock [Line Items] |
|
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34,860
|
Series F-4 |
|
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|
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24,900
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v3.24.1.1.u2
Stockholders' Equity - Authorized Shares and Preferred Stock (Details) - $ / shares
|
Mar. 31, 2024 |
Dec. 31, 2023 |
Mar. 31, 2023 |
Stockholders Equity Note [Line Items] |
|
|
|
Common stock, shares authorized (in shares) |
80,000,000
|
80,000,000
|
|
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$ 0.01
|
$ 0.01
|
$ 0.01
|
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10,000,000
|
10,000,000
|
|
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$ 0.01
|
$ 0.01
|
$ 0.01
|
Preferred stock, shares outstanding (in shares) |
16,809
|
24,819
|
|
Series E |
|
|
|
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|
|
|
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11,257
|
|
|
Series E-1 |
|
|
|
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|
|
|
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11,257
|
|
|
Series F-2 |
|
|
|
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|
|
|
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$ 3.30
|
|
|
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2,542
|
|
|
Series F-3 |
|
|
|
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|
|
|
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$ 4.50
|
|
|
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3,010
|
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v3.24.1.1.u2
Stockholders' Equity - Summary of Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands |
3 Months Ended |
12 Months Ended |
Mar. 31, 2024 |
Dec. 31, 2023 |
Number of Options |
|
|
Outstanding, beginning of period (in shares) |
4,183,232
|
|
Granted (in shares) |
2,017,596
|
|
Expired (in shares) |
(15,341)
|
|
Cancelled/Forfeited (in shares) |
(146,312)
|
|
Outstanding, end of period (in shares) |
6,039,175
|
4,183,232
|
Exercisable (in shares) |
2,569,497
|
|
Unvested at March 31, 2024 (in shares) |
3,469,678
|
|
Weighted Average Exercise Price Per Share |
|
|
Outstanding, Weighted Average Exercise Price Per Share, beginning of period (in dollars per share) |
$ 8.17
|
|
Granted, Weighted Average Exercise Price Per Share (in dollars per share) |
4.80
|
|
Expired, Weighted Average Exercise Price Per Share (in dollars per share) |
7.16
|
|
Cancelled-Forfeited, Weighted Average Exercise Price Per Share (in dollars per share) |
6.08
|
|
Outstanding, Weighted Average Exercise Price Per Share, end of period (in dollars per share) |
7.10
|
$ 8.17
|
Weighted Average Exercise Price, Exercisable (in dollars per share) |
9.47
|
|
Weighted Average Exercise Price, Unvested (in dollars per share) |
5.34
|
|
Weighted Average Grant Date Fair Value Per Share |
|
|
Outstanding, Weighted average grant date fair value at beginning of period (in dollars per share) |
7.60
|
|
Weighted average estimated fair value of the stock options granted (in dollars per share) |
3.92
|
|
Expired, Weighted average grant date fair value (in dollars per share) |
6.91
|
|
Expired, Weighted average grant date fair value (in dollars per share) |
5.75
|
|
Ending, Weighted average grant date fair value at beginning of period (in dollars per share) |
6.42
|
$ 7.60
|
Exercisable, Weighted average grant date fair value (in dollars per share) |
8.73
|
|
Unvested Weighted average grant date fair value (in dollars per share) |
$ 4.70
|
|
Weighted Average Remaining Contractual Term (in years) and Aggregate Intrinsic Value |
|
|
Weighted Average Remaining Contractual Term (in years), Outstanding |
8 years 7 months 6 days
|
8 years 3 months 18 days
|
Weighted Average Remaining Contractual Term (in years), Granted |
9 years 8 months 12 days
|
|
Weighted Average Remaining Contractual Term (in years), Exercisable |
7 years 4 months 24 days
|
|
Weighted Average Remaining Contractual Term (in years), Unvested |
9 years 4 months 24 days
|
|
Aggregate Intrinsic Value, Outstanding |
$ 433
|
$ 147
|
Aggregate Intrinsic Value, Exercisable |
74
|
|
Aggregate Intrinsic Value, Unvested |
$ 358
|
|
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v3.24.1.1.u2
Stockholders' Equity - Summary of Stock Option Shares Outstanding and Exercisable (Details) - $ / shares
|
3 Months Ended |
12 Months Ended |
Mar. 31, 2024 |
Dec. 31, 2023 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
Outstanding Number of Options (in shares) |
6,039,175
|
4,183,232
|
Weighted Average Remaining Option Term (in years), Options Outstanding |
8 years 7 months 6 days
|
8 years 3 months 18 days
|
Number of Options Exercisable (in shares) |
6,039,175
|
4,183,232
|
$2.83 - $51.50 |
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
Outstanding Number of Options (in shares) |
6,038,676
|
|
Weighted Average Remaining Option Term (in years), Options Outstanding |
8 years 7 months 6 days
|
|
Number of Options Exercisable (in shares) |
6,038,676
|
|
$2.83 - $51.50 | Minimum |
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
Range of Exercise Prices (in dollars per share) |
$ 2.83
|
|
$2.83 - $51.50 | Maximum |
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
Range of Exercise Prices (in dollars per share) |
51.50
|
|
$51.50+ |
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
Range of Exercise Prices (in dollars per share) |
$ 51.50
|
|
Outstanding Number of Options (in shares) |
499
|
|
Weighted Average Remaining Option Term (in years), Options Outstanding |
4 years 9 months 18 days
|
|
Number of Options Exercisable (in shares) |
499
|
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Stockholders' Equity - Summary of Recognized Share-based Compensation Cost (Details) - USD ($) $ in Thousands |
3 Months Ended |
Mar. 31, 2024 |
Mar. 31, 2023 |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
Share-based compensation expense |
$ 2,945
|
$ 1,661
|
Unrecognized compensation expense related to non-vested share-based compensation awards |
$ 10,300
|
|
Cost expected to be recognized over weighted average period |
1 year 2 months 12 days
|
|
Selling, general and administrative |
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
Share-based compensation expense |
$ 2,042
|
1,118
|
Research and development |
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
Share-based compensation expense |
647
|
417
|
Cost of goods sold |
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
Share-based compensation expense |
$ 256
|
$ 126
|
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- DefinitionAmount of expense for award under share-based payment arrangement. Excludes amount capitalized.
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Stockholders' Equity - Summary of Common Stock Warrant Activity (Details) - Common Warrants - $ / shares
|
3 Months Ended |
12 Months Ended |
Mar. 31, 2024 |
Dec. 31, 2023 |
Class Of Warrant Or Right Outstanding [Roll Forward] |
|
|
Outstanding, beginning of period (in shares) |
4,665,201
|
|
Warrants issued (in shares) |
1,008,102
|
|
Warrants exercised (in shares) |
0
|
|
Outstanding, end of period (in shares) |
5,673,303
|
4,665,201
|
Exercisable, end of period (in shares) |
5,673,303
|
|
Weighted Average Exercise Price |
|
|
Outstanding, beginning of period (in dollars per share) |
$ 7.76
|
|
Warrants issued (in dollars per share) |
0.01
|
|
Warrants exercised (in dollars per share) |
0
|
|
Outstanding, ending of period (in dollars per share) |
|
$ 7.76
|
Exercisable, (in dollars per share) |
$ 6.39
|
|
Weighted Average Remaining Life (in years) |
|
|
Weighted Average Remaining Life (in years), Outstanding |
2 years
|
1 year 7 months 6 days
|
Weighted Average Remaining Life, Issued |
5 years
|
|
Weighted Average Remaining Life, Exercisable |
2 years
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v3.24.1.1.u2
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|
3 Months Ended |
12 Months Ended |
|
|
Mar. 31, 2024 |
Dec. 31, 2023 |
Mar. 31, 2023 |
Aug. 06, 2021 |
Class of Warrant or Right [Line Items] |
|
|
|
|
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|
|
$ 0.01
|
$ 0.01
|
Common Warrants |
|
|
|
|
Class of Warrant or Right [Line Items] |
|
|
|
|
Outstanding Number of Warrants (in shares) |
5,673,303
|
4,665,201
|
|
|
Warrants Exercisable, Weighted Average Remaining Warrant Term (in years) |
2 years
|
1 year 7 months 6 days
|
|
|
Warrants Exercisable, Number of Warrants (in shares) |
5,673,303
|
|
|
|
$0.01 |
|
|
|
|
Class of Warrant or Right [Line Items] |
|
|
|
|
Warrant exercise price (in dollars per share) |
$ 0.01
|
|
|
|
$0.01 | Common Warrants |
|
|
|
|
Class of Warrant or Right [Line Items] |
|
|
|
|
Outstanding Number of Warrants (in shares) |
2,045,894
|
|
|
|
Warrants Exercisable, Weighted Average Remaining Warrant Term (in years) |
4 years
|
|
|
|
Warrants Exercisable, Number of Warrants (in shares) |
2,045,894
|
|
|
|
$6.00 |
|
|
|
|
Class of Warrant or Right [Line Items] |
|
|
|
|
Warrant exercise price (in dollars per share) |
$ 6.00
|
|
|
|
$6.00 | Common Warrants |
|
|
|
|
Class of Warrant or Right [Line Items] |
|
|
|
|
Outstanding Number of Warrants (in shares) |
16,666
|
|
|
|
Warrants Exercisable, Weighted Average Remaining Warrant Term (in years) |
2 years
|
|
|
|
Warrants Exercisable, Number of Warrants (in shares) |
16,666
|
|
|
|
$10.00 |
|
|
|
|
Class of Warrant or Right [Line Items] |
|
|
|
|
Warrant exercise price (in dollars per share) |
$ 10
|
|
|
|
$10.00 | Common Warrants |
|
|
|
|
Class of Warrant or Right [Line Items] |
|
|
|
|
Outstanding Number of Warrants (in shares) |
3,610,743
|
|
|
|
Warrants Exercisable, Weighted Average Remaining Warrant Term (in years) |
1 year
|
|
|
|
Warrants Exercisable, Number of Warrants (in shares) |
3,610,743
|
|
|
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Stockholders' Equity - Preferred Stock Warrants (Details) - Preferred Warrants - $ / shares
|
3 Months Ended |
12 Months Ended |
Mar. 31, 2024 |
Dec. 31, 2023 |
Class of Warrant or Right [Line Items] |
|
|
Outstanding, beginning of period (in shares) |
24,900
|
|
Warrants issued (in shares) |
0
|
|
Warrants exercised (in shares) |
0
|
|
Outstanding, end of period (in shares) |
24,900
|
24,900
|
Warrants Exercisable, Number of Warrants (in shares) |
24,900
|
|
Outstanding, beginning of period (in dollars per share) |
$ 1,000
|
|
Warrants issued (in dollars per share) |
|
|
Warrants exercised (in dollars per share) |
|
|
Outstanding, ending of period (in dollars per share) |
1,000
|
$ 1,000
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Warrants Exercisable, Weighted Average Exercise Price |
$ 1,000
|
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Warrants Exercisable, Weighted Average Remaining Warrant Term (in years) |
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v3.24.1.1.u2
Net Loss per Share - Anti-Dilutive Securities Excluded from Computation of Earnings Per Share (Details) - shares
|
3 Months Ended |
Mar. 31, 2024 |
Mar. 31, 2023 |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive securities excluded from computation of earnings per share (in shares) |
16,869,520
|
27,618,787
|
Common stock warrants |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive securities excluded from computation of earnings per share (in shares) |
3,627,409
|
3,658,520
|
Assumed conversion of preferred stock warrants |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive securities excluded from computation of earnings per share (in shares) |
4,149,994
|
11,896,667
|
Assumed conversion of preferred stock |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive securities excluded from computation of earnings per share (in shares) |
2,564,911
|
8,681,176
|
Assumed conversion of convertible notes |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive securities excluded from computation of earnings per share (in shares) |
488,031
|
488,031
|
Stock options |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive securities excluded from computation of earnings per share (in shares) |
6,039,175
|
2,894,393
|
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Net Loss per Share - Summary of Reconciliation of Weighted Average Shares Outstanding Calculation (Details) - shares
|
3 Months Ended |
Mar. 31, 2024 |
Mar. 31, 2023 |
Earnings Per Share [Abstract] |
|
|
Weighted average shares issued (in shares) |
23,705,374
|
10,081,634
|
Weighted average pre-funded warrants (in shares) |
1,181,806
|
1,540,750
|
Weighted average number of basic shares outstanding (in shares) |
24,887,180
|
11,622,384
|
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24,887,180
|
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Commitments and Contingencies (Details) $ in Thousands, € in Millions |
May 01, 2024 |
Dec. 30, 2022
USD ($)
|
Mar. 31, 2024
USD ($)
|
Oct. 12, 2021
EUR (€)
|
Apr. 30, 2021
EUR (€)
|
Loss Contingencies [Line Items] |
|
|
|
|
|
Milestone payment unpaid | € |
|
|
|
€ 1
|
|
Purchase obligation, remainder of fiscal year |
|
|
$ 2,250
|
|
|
Subsequent Event |
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
Supply agreement, renewal option term |
5 years
|
|
|
|
|
Medac |
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
Accounts receivable | € |
|
|
|
|
€ 1
|
Term over which the royalty is to be paid |
|
5 years
|
|
|
|
Minimum annual payments |
|
$ 200
|
|
|
|
Other Liabilities | Medac |
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
Loss contingency accrual |
|
|
1,000
|
|
|
Other Noncurrent Liabilities | Medac |
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
Loss contingency accrual |
|
|
800
|
|
|
Accrued Expenses | Medac |
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
Loss contingency accrual |
|
|
$ 200
|
|
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v3.24.1.1.u2
Fair Value Measurements - Fair Value Measurements Using Significant Unobservable Inputs (Details) - USD ($) $ in Thousands |
3 Months Ended |
Mar. 31, 2024 |
Mar. 31, 2023 |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |
|
|
Beginning balance |
$ 6,544
|
|
Total change in foreign exchange |
(22)
|
|
Warrant liability fair value adjustment |
612
|
$ 0
|
Change due to warrant exercise |
0
|
|
Ending balance |
7,134
|
|
Contingent liabilities |
|
|
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |
|
|
Beginning balance |
996
|
|
Total change in foreign exchange |
(22)
|
|
Warrant liability fair value adjustment |
0
|
|
Change due to warrant exercise |
0
|
|
Ending balance |
974
|
|
Warrants |
|
|
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |
|
|
Beginning balance |
5,548
|
|
Total change in foreign exchange |
0
|
|
Warrant liability fair value adjustment |
612
|
|
Change due to warrant exercise |
0
|
|
Ending balance |
$ 6,160
|
|
X |
- DefinitionAmount of expense (income) related to adjustment to fair value of warrant liability.
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Mar. 31, 2024 |
Dec. 31, 2023 |
Assets: |
|
|
Total Assets |
$ 15,432
|
$ 20,200
|
Liabilities: |
|
|
Contingent Liability |
974
|
996
|
Warrant Liabilities |
6,160
|
5,548
|
Total Liabilities |
7,134
|
6,544
|
Money market funds |
|
|
Assets: |
|
|
Investments |
72
|
392
|
U.S. government agency bonds |
|
|
Assets: |
|
|
Investments |
15,360
|
19,808
|
Quoted Prices in Active Markets (Level 1) |
|
|
Assets: |
|
|
Total Assets |
72
|
392
|
Liabilities: |
|
|
Contingent Liability |
0
|
0
|
Warrant Liabilities |
0
|
0
|
Total Liabilities |
0
|
0
|
Quoted Prices in Active Markets (Level 1) | Money market funds |
|
|
Assets: |
|
|
Investments |
72
|
392
|
Quoted Prices in Active Markets (Level 1) | U.S. government agency bonds |
|
|
Assets: |
|
|
Investments |
0
|
0
|
Significant Other Observable Inputs (Level 2) |
|
|
Assets: |
|
|
Total Assets |
15,360
|
19,808
|
Liabilities: |
|
|
Contingent Liability |
0
|
0
|
Warrant Liabilities |
0
|
0
|
Total Liabilities |
0
|
0
|
Significant Other Observable Inputs (Level 2) | Money market funds |
|
|
Assets: |
|
|
Investments |
0
|
0
|
Significant Other Observable Inputs (Level 2) | U.S. government agency bonds |
|
|
Assets: |
|
|
Investments |
15,360
|
19,808
|
Significant Unobservable Inputs (Level 3) |
|
|
Assets: |
|
|
Total Assets |
0
|
0
|
Liabilities: |
|
|
Contingent Liability |
974
|
996
|
Warrant Liabilities |
6,160
|
5,548
|
Total Liabilities |
7,134
|
6,544
|
Significant Unobservable Inputs (Level 3) | Money market funds |
|
|
Assets: |
|
|
Investments |
0
|
0
|
Significant Unobservable Inputs (Level 3) | U.S. government agency bonds |
|
|
Assets: |
|
|
Investments |
$ 0
|
$ 0
|
X |
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