Galectin Therapeutics Inc (GALT) News

Correct, I have read this happening many times over the past 30 years, but then again maybe it's all just a conspiracy theory! LMAO
Nothing wrong being a short based on fundamentals. Lying though doesn't cut it and there are plenty of them in the past few years. All grads from the Sykes School for Idiots. Earning the tuition fee brings out the panic and stress for such "students".

can you explain in detail how they are ineffective. Thanks

Your quote does not refute or cancel out the conclusion from Dr. Chalasani, who is looking at all the data in great detail (more than what we have access to). His conclusion of reproducible benefit is a strong statement for significant value of belapectin in cirrhosis.

Not sure why you bring up Jim. His only involvement in recent years is being a large shareholder and he's not involved with managing the company in any way; he is not even on the board anymore.

Actually this quote sums up the whole situation perfectly:

“ While there was a favorable trend for incidence of varices in the primary end point intent-to-treat population, belapectin did not achieve statistical significance”

And not only do I understand pharmaceutical research extremely well, I don’t feel the need to make excuses for serial cheats and liars like Jim Czirr.

This quote sums it up succinctly. Dr. Chalasani has an impeccable reputation, a respected authority in the field, and he would not make up something that he doesn't believe and have evidence for.

"Belapectin clearly is offering a reproducible benefit and should be continued in clinical development as there is a significant unmet need for patients with MASH cirrhosis.” - Dr. Naga Chalasani

Dr. Chalasani is considered an authority in the fields of Nonalcoholic Fatty Liver Disease (NAFLD) and Drug Induced Liver Injury (DILI), two highly significant public health problems. His research has been continuously funded by the National Institutes of Health since 1999. He is currently the PI for three U01 awards and an R01 award from the National Institutes of Health. He published over 300 original papers, 3 Practice Guidelines, 47 book chapters/review articles, 31 editorials/commentaries, 16 symposium proceedings, and more than 500 abstracts. He has co-edited a textbook with Prof. Gyongyi Szabo titled ‘Alcoholic & Nonalcoholic Fatty Liver Disease – Bench to bedside’ (Springer 2015). He is the lead author for the AASLD Practice Guideline on the Diagnosis and Management of Nonalcoholic Fatty Liver Disease.

Some people posting here do not understand pharmacology.

A less effective higher dose happens sometimes especially in immunology (keep in mind that galectins are native immune system proteins that modulate macrophage polarization to affect fibrotic pathways). Examples of other common drugs exhibiting this behavior include immunomodulators, beta-blockers, and hormonal therapies, among others.

Why Higher Doses Can Appear Less Effective
In some studies, high doses of a drug can paradoxically look less effective. This can happen due to several factors:

- Reduced Receptor Turnover: If the target proteins (Galectin-3) are already occupied, additional drug might not only fail to add benefit but could also alter how the body handles or clears the complex, changing the dynamic equilibrium.

- Changes in Drug Clearance or Metabolism: Higher levels of belapectin might trigger regulatory mechanisms in the liver or kidneys that clear the drug more rapidly, resulting in reduced steady-state concentrations at the target site over time.

- Potential Off-Target Effects: Excess drug can bind weakly to non-target proteins or set off other responses, sometimes counteracting the positive effects seen at lower doses.

Hope you listened to your more cautious advice to yourself.

I rather think you missed the point. It’s not that higher doses of GALT’s drug are toxic, it’s that they are ineffective.

Given the purported mechanism, that almost certainly means lower doses are too, and that the implication that the lower dose worked is merely an artefact.

I rather like it here and have posted on this MB for over a decade. I’ll hang around whether you like it or not.

Insider director buy a day ago, above the price I paid days ago.

I like it, I love it, I want some more of it.

Shorts have no shares left to borrow and the cost to borrow is 98%
Holy shit Sherlock, never seen that before. Ever heard of a bear trap?
The guy funding GALT is no Dummy, and experienced and super rich $$$$$$.

⌛️⌛️⌛️ ⌛️ ⌛️

https://ih.advfn.com/stock-market/NASDAQ/galectin-therapeutics-GALT/stock-news/95177233/form-4-statement-of-changes-in-beneficial-owners

Indeed:

Superior article and well written by Zerohedge. It not only explains and identifies the efficacies, but exposes the real world greed factors that are slowing down progress by the research that should be getting the attention and funding. So looking forward to the new bosses at our health agencies that seem to be raring to go in cleaning up the corruption within the FDA etc and Big Pharma. Thanks for posting this article.

#DHMO is deadly in higher doses as well, but life can not exist with out it.

https://www.DHMO.org

There is no logic or basis in that BS you posted. Shorts are drowning with no shares left to borrow. They dug their own grave.

So move along little short doggie.

Superior article and well writtien by Zerohedge. It not only explains and identifies the efficacies but exposes the real world greed factors that are slowing down progress by the research that should be getting the attention and funding. So looking forward to the new bosses at our health agencies that seem to be raring to go in cleaning up the corruption within the FDA etc and Big Pharma. Thanks for posting this article.

I sold everything.  Big loss but wasn't going to wait this out further.  It's a shame mgmt was so confident back in April.  Baby biotechs simply haven't been good to me.  

When the lower dose appears to work better than the higher dose, the straw-grasping begins.

Seasoned pharma aficionados know that in reality it was a data artefact and that means the drug doesn’t work, which is why neither dose was better than placebo.

Quelle surprise.

GALT bad results 

Ok I wasn't sure if your referring to bixt Galt or both.  Mike sheikh is part of bixt.  Not Galt as far as I know.  Are they both scams or just Galt? 

Nope. I never short stocks. Too risky.

I'm in the camp that thinks GALT/PRWP has always been long on lies and short on real drug candidates.

So your in the short camp?  

Adam F is right about GALT, just like The Boston Globe was right about PRWP, GALT’s previous incarnation.

https://www.thestreet.com/investing/stocks/biotech-stock-mailbag-aspenbio-10741455

https://www.insiderfinancial.com/post/short-mafia-attacking-galectin-therapeutics-nasdaq-galt-ahead-of-planned-year-end-readout

https://www.insiderfinancial.com/post/galectin-therapeutics-nasdaq-galt-disrupting-mercks-cancer-dominance

GALT MENTIONED IN THIS ARTICLE

https://www.zerohedge.com/news/2024-10-15/what-merck-doesnt-want-you-know-about-keytruda

Please watch this and comment your opinion

Any company that has Ben Carson on its BoD is doomed to failure.

Good things about to happen here

https://www.globenewswire.com/news-release/2024/06/27/2905450/0/en/Bioxytran-s-Advisor-Releases-Book-on-Hyperbaric-Oxygenation-Related-to-Stroke-Alzheimer-s-Patients.html

https://medicaldialogues.in/medicine/news/galectin-3-promising-biomarker-for-predicting-long-covid-among-patients-of-covid-19-study-129158

Todays emerging growth conference
CEO DAVID PLATT $BIXT
BioxyTran.

https://emerginggrowth.com/emerging-growth-conference-70/

https://www.nasdaq.com/press-release/6-stocks-positioned-to-soar-as-investors-focus-on-mash-2024-04-22

Reached a peak.

Letting some air out today !!

But I had 20,000 !!!

AND AT 2.45...YA GOT ME BEAT BIG TIME!

ONLY...LOL...I ONLY HAVE A 1000..NICE WORK CHAMP!!

Man , I only bought 5000 shares at 1.20 . Happy but I should have loaded the boat a bit more.

GALT...THESE BIO BEAST OF THE BIO MARKET

https://www.insiderfinancial.com/post/galectin-therapeutics-galt-a-discount-opportunity-moving-on-analysts-upgrade

Hey look at this;
GALT shareholders!
If you want an alternative to or additionally own a Galectin drug by the creator of Galectin antagonist, Dr Platt the father of the new science glycovirlogy

Viruses
Cancer
And hypoxia drug! BXT 25

https://www.insiderfinancial.com/post/galectin-therapeutics-galt-a-discount-opportunity-moving-on-analysts-upgrade

GALT..THE BIO BEAST THAT KEEPS BEASTING...

GALT the bio beast of the bio techs

GALT new 52 hi

GALT BREAKING OUT

Play the chart not the story and sell before news

What do we think this run is credited to ?? Our data readout isn’t until Q4??

GALT WEEKLY BREAK OUT HERE IS STRONG

GALT new 52 hi

GALT BIO BEAST!!!

Just trying to justify the run here. I’m happy of course , my entry was 1.20

So sell short