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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section
13 OR 15(d) of The Securities Exchange Act of 1934
Date of Report (Date
of earliest event reported): February 14, 2024
Outlook Therapeutics,
Inc.
(Exact name of registrant
as specified in its charter)
Delaware |
001-37759 |
38-3982704 |
(State or other jurisdiction
of incorporation) |
(Commission File Number) |
(IRS Employer Identification No.) |
485 Route 1 South
Building F, Suite 320
Iselin, New Jersey |
08830 |
(Address of principal executive offices) |
(Zip Code) |
Registrant’s telephone number, including area code:
(609) 619-3990
(Former
name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under
any of the following provisions (see General Instructions A.2. below):
¨ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
|
|
¨ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
|
|
¨ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
|
|
¨ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
|
Trading Symbol(s) |
|
Name of each exchange
on which registered |
Common stock |
|
OTLK |
|
The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant is an emerging growth
company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange
Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ¨
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 13(a) of the Exchange Act. ¨
Item 2.02 |
Results of Operations and Financial Condition |
On February 14, 2024, Outlook Therapeutics,
Inc. (the “Company”) issued a press release announcing its financial results for its first fiscal quarter ended December 31,
2023. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.
The information contained in this
Item 2.02 and in the accompanying Exhibit 99.1 shall not be deemed filed for purposes of Section 18 of the Securities Exchange Act of
1934, as amended (the “Exchange Act”), or incorporated by reference in any filing under the Exchange Act or the Securities
Act of 1933, as amended, except as shall be expressly set forth by specific reference in such filing.
Item 9.01 |
Financial Statements and Exhibits |
(d) Exhibits.
SIGNATURES
Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
|
Outlook Therapeutics, Inc. |
|
|
Date: February 14, 2024 |
By: |
/s/ Lawrence A. Kenyon |
|
|
Lawrence A. Kenyon |
|
|
Chief Financial Officer |
Exhibit 99.1
Outlook Therapeutics® Reports Financial
Results for First Quarter Fiscal Year 2024 and Provides Corporate Update
| · | NORSE EIGHT underway with first subject dosed and additional clinical sites beginning enrollment |
| · | Continue to expect planned resubmission of the ONS-5010 Biologics License Application (BLA) by the end of CY2024 |
| · | Anticipate review decision from European regulators in the first half of CY2024 |
ISELIN,
N.J., February 14, 2024 — Outlook Therapeutics, Inc. (Nasdaq: OTLK), a biopharmaceutical company working to achieve regulatory
approval for the first ophthalmic formulation of bevacizumab for the treatment of retinal diseases, today announced financial results
for first quarter fiscal year 2024 and provided a corporate update.
“We are proud of the recent progress our
team has made. In January 2024, we received confirmation that the FDA has reviewed and agreed upon the NORSE EIGHT trial protocol pursuant
to the SPA they approved. We also reached agreement that if the NORSE EIGHT trial is successful, it would satisfy the FDA’s requirement
for a second adequate and well-controlled clinical trial to address fully the clinical deficiency identified in the CRL. Importantly,
the first subject was enrolled in NORSE EIGHT in January 2024,” commented Russell Trenary, President and Chief Executive Officer.
“In addition, through a Type A meeting and additional interactions, we have identified the approaches needed to resolve the CMC
comments in the CRL. We are working to address the open items and expect to resolve these comments prior to the expected completion of
NORSE EIGHT. Finally, we have entered into purchase agreements for a financing of up to $172 million, subject to shareholder approval,
to support our regulatory efforts and launch preparations.”
Upcoming Anticipated Milestones
| · | Closing
of private placement financing in March 2024, subject to receipt of stockholder approval
and other closing conditions; |
| · | MAA
decision date in the EU for ONS-5010 targeted for first half of 2024; |
| · | Completion
of NORSE EIGHT in the United States anticipated in 2024; and |
| · | Resubmission
of the ONS-5010 BLA expected by the end of calendar year 2024. |
ONS-5010 / LYTENAVA™ (bevacizumab-vikg)
Regulatory Update
As previously announced, following a Type A meeting
with the FDA in October 2023, the FDA informed Outlook Therapeutics that it can conduct a non-inferiority study evaluating ONS-5010 versus
ranibizumab in a 3-month study of treatment naïve patients with a primary efficacy endpoint at 2 months (NORSE EIGHT). In January
2024, Outlook Therapeutics announced that it received written agreement on the NORSE EIGHT trial protocol from the FDA under a SPA for
NORSE EIGHT. The SPA confirms that if the NORSE EIGHT trial is successful, it would satisfy the FDA’s requirement for a second
adequate and well-controlled clinical trial to fully address the clinical deficiency identified in the Complete Response Letter (CRL).
In addition, through a Type A meeting and additional interactions, Outlook Therapeutics has identified the approaches needed to resolve
the Chemistry, Manufacturing and Controls (CMC) comments in the CRL. Outlook Therapeutics is working to address the open CMC items in
the CRL and expects to resolve these comments prior to the expected completion of NORSE EIGHT.
NORSE EIGHT is a randomized, controlled, parallel-group,
masked, non-inferiority study of approximately 400 newly diagnosed, wet AMD subjects randomized in a 1:1 ratio to receive 1.25 mg ONS-5010
or 0.5 mg ranibizumab intravitreal injections. Subjects will receive injections at Day 0 (randomization), Week 4, and Week 8 visits.
The primary endpoint will be mean change in BCVA from baseline to week 8. Outlook Therapeutics expects NORSE EIGHT topline results and
resubmission of the ONS-5010 BLA by the end of calendar year 2024.
Additionally, the formal review process of the
ONS-5010 MAA by the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) is underway with an estimated
decision date expected in the first half of 2024. In addition to pursuing potential strategic partnering opportunities in the EU and
other regions, Outlook Therapeutics is also exploring potential expanded relationships with Cencora (formerly AmerisourceBergen) to support
the launch of ONS-5010 in international markets.
If approved, ONS-5010 / LYTENAVA™ (bevacizumab-vikg)
would be the first approved ophthalmic formulation of bevacizumab in the U.S. or EU.
Financial Highlights for the Fiscal First Quarter Ended December 31, 2023
For the fiscal first quarter ended December 31,
2023, Outlook Therapeutics reported a net loss attributable to common stockholders of $11.2 million, or $0.04 per basic and diluted share,
compared to a net loss attributable to common stockholders of $18.7 million, or $0.08 per basic and diluted share, for the same period
last year.
In January 2024, the Company announced that it
has entered into definitive securities purchase agreements with certain institutional and accredited investors to purchase shares of
common stock and accompanying warrants in private placements, the closing of which is conditioned upon stockholder approval of the transactions
and certain other corporate actions, expected in the first quarter of 2024. The private placements are expected to provide up to $65
million in gross proceeds at closing, before deducting placement agent fees and offering expenses. In addition, Outlook Therapeutics
will have the potential to receive additional gross proceeds of up to $107 million upon the full cash exercise of the warrants being
issued in the private placements, before deducting placement agent fees and offering expenses. The warrants include a feature that allows
Outlook Therapeutics to require cash exercise if certain stock price and milestone conditions are met.
At December 31, 2023, Outlook Therapeutics had
cash and cash equivalents of $10.4 million. Assuming closing of the private placements as planned (subject to closing conditions) and
full cash exercise of the related warrants, the proceeds from the private placements are expected to support business operations, complete
the execution of NORSE EIGHT, resubmit the ONS-5010 BLA and, if approved, support the commercial launch of ONS-5010.
About ONS-5010 / LYTENAVA™ (bevacizumab-vikg)
ONS-5010 is an investigational ophthalmic formulation of bevacizumab under development as an intravitreal injection for the treatment
of wet AMD and other retinal diseases. Because no FDA-approved ophthalmic formulations of bevacizumab are available currently, clinicians
wishing to treat retinal patients with bevacizumab have had to use unapproved repackaged IV bevacizumab provided by compounding pharmacies—products
that have known risks of contamination and inconsistent potency and availability. If approved, ONS-5010 would provide an FDA-approved
option for physicians that currently prescribe unapproved repackaged oncologic IV bevacizumab from compounding pharmacies for the treatment
of wet AMD.
Bevacizumab-vikg is a recombinant humanized monoclonal
antibody (mAb) that selectively binds with high affinity to all isoforms of human vascular endothelial growth factor (VEGF) and neutralizes
VEGF’s biologic activity through a steric blocking of the binding of VEGF to its receptors Flt-1 (VEGFR-1) and KDR (VEGFR-2) on
the surface of endothelial cells. Following intravitreal injection, the binding of bevacizumab-vikg to VEGF prevents the interaction of
VEGF with its receptors on the surface of endothelial cells, reducing endothelial cell proliferation, vascular leakage, and new blood
vessel formation in the retina.
About Outlook Therapeutics, Inc.
Outlook Therapeutics is a biopharmaceutical company working to achieve FDA and EMA approval for the launch of ONS-5010/ LYTENAVA™
(bevacizumab-vikg) as the first FDA-approved ophthalmic formulation of bevacizumab for use in retinal indications, including wet AMD,
DME and BRVO. If ONS-5010 ophthalmic bevacizumab is approved, Outlook Therapeutics expects to commercialize it as the first and only FDA
and/or EMA approved ophthalmic formulation of bevacizumab for use in treating retinal diseases in the United States, United Kingdom, Europe,
Japan, and other markets. As part of the Outlook Therapeutics' multi-year commercial planning process, Outlook Therapeutics and Cencora
entered into a strategic commercialization agreement to expand the Outlook Therapeutics’ reach for connecting to retina specialists
and their patients. Cencora will provide third-party logistics (3PL) services and distribution, as well as pharmacovigilance services
and other services in the United States. For more information, please visit www.outlooktherapeutics.com.
Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical facts are “forward-looking
statements,” including those relating to future events. In some cases, you can identify forward-looking statements by terminology
such as “anticipate,” “believe,” “continue,” “estimate,” “expect,” “intend,”
“may,” “plan,” “potential,” “target,” “will,” or “would” the negative
of terms like these or other comparable terminology, and other words or terms of similar meaning. These include, among others, statements
about ONS-5010’s potential as the first FDA-approved ophthalmic formulation of bevacizumab-vikg, expectations concerning Outlook
Therapeutics’ ability to remediate or otherwise resolve deficiencies identified in the CRL issued by the FDA, including with respect
to an additional clinical trial and CMC issues, expectations concerning the NORSE EIGHT trial design, the timing for completion of NORSE
EIGHT and resubmission of the BLA for ONS-5010, the private placement, including expected proceeds from the issuance of the shares of
common stock and exercise of the warrants, satisfaction of closing conditions, including receipt of necessary stockholder approvals, and
uses of proceeds, the sufficiency of Outlook Therapeutics’ resources, including funds from the financing, to fund its operations
through various milestones, expectations concerning decisions of regulatory bodies, including the FDA and EMA, and the timing thereof,
plans for potential commercial launch of ONS-5010, expectations concerning the relationship with Cencora and the benefits and potential
expansion thereof, and other statements that are not historical fact. Although Outlook Therapeutics believes that it has a reasonable
basis for the forward-looking statements contained herein, they are based on current expectations about future events affecting Outlook
Therapeutics and are subject to risks, uncertainties and factors relating to its operations and business environment, all of which are
difficult to predict and many of which are beyond its control. These risk factors include those risks associated with developing pharmaceutical
product candidates, risks of conducting clinical trials and risks in obtaining necessary regulatory approvals, the content and timing
of decisions by the FDA, receipt of necessary stockholder approvals for the private placements, as well as those risks detailed in Outlook
Therapeutics’ filings with the Securities and Exchange Commission (the SEC), including the Annual Report on Form 10-K for the fiscal
year ended September 30, 2023, filed with the SEC on December 22, 2023, and future quarterly reports Outlook Therapeutics files with the
SEC, which include uncertainty of market conditions and future impacts related to macroeconomic factors, including as a result of the
ongoing overseas conflict, high interest rates, inflation and potential future bank failures on the global business environment. These
risks may cause actual results to differ materially from those expressed or implied by forward-looking statements in this press release.
All forward-looking statements included in this press release are expressly qualified in their entirety by the foregoing cautionary statements.
You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Outlook Therapeutics
does not undertake any obligation to update, amend or clarify these forward-looking statements whether as a result of new information,
future events or otherwise, except as may be required under applicable securities law.
Investor Inquiries:
Jenene Thomas
Chief Executive Officer
JTC Team, LLC
T: 833.475.8247
OTLK@jtcir.com
Outlook Therapeutics, Inc. |
Consolidated Statements of Operations |
(Amounts in thousands, except per share data) | |
|
| |
| | |
| |
| |
Three months ended December 31, | |
| |
2023 | | |
2022 | |
Operating expenses: | |
| | | |
| | |
Research and development | |
$ | 4,529 | | |
$ | 9,862 | |
General and administrative | |
| 5,794 | | |
| 5,826 | |
| |
| 10,323 | | |
| 15,688 | |
Loss from operations | |
| (10,323 | ) | |
| (15,688 | ) |
Income on equity method investment | |
| (3 | ) | |
| (22 | ) |
Interest (income) expense, net | |
| (188 | ) | |
| 2,449 | |
Loss on extinguishment of debt | |
| - | | |
| 578 | |
Change in fair value of promissory notes | |
| 993 | | |
| - | |
Change in fair value of warrant liability | |
| 53 | | |
| (30 | ) |
Net loss attributable to common stockholders | |
$ | (11,178 | ) | |
$ | (18,663 | ) |
| |
| | | |
| | |
Per share information: | |
| | | |
| | |
Net loss per share of common stock, basic and diluted | |
$ | (0.04 | ) | |
$ | (0.08 | ) |
Weighted average shares outstanding, basic and diluted | |
| 260,258 | | |
| 227,411 | |
Consolidated Balance Sheet Data |
(Amounts in thousands) |
|
| |
| | |
| |
| |
December 31, 2023 | | |
September 30, 2023 | |
Cash and cash equivalents | |
$ | 10,357 | | |
$ | 23,392 | |
Total assets | |
$ | 21,685 | | |
$ | 32,301 | |
Current liabilities | |
$ | 45,969 | | |
$ | 46,732 | |
Total stockholders' deficit | |
$ | (24,343 | ) | |
$ | (14,438 | ) |
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