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United
States
Securities
and Exchange Commission
Washington,
D.C. 20549
FORM
10-Q
(Mark
One)
☒ |
QUARTERLY
REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For
the quarterly period ended June 30, 2023
or
☐ |
TRANSITION
REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For
the transition period from ____ to ____
Commission
File Number 001-39531
Processa
Pharmaceuticals, Inc.
(Exact
name of registrant as specified in its charter)
Delaware |
|
45-1539785 |
(State
or other jurisdiction
of
incorporation or organization) |
|
(IRS
Employer
Identification
No.) |
7380
Coca Cola Drive, Suite 106,
Hanover,
Maryland 21076
(443)
776-3133
Securities
registered pursuant to Section 12(b) of the Exchange Act:
Title
of Each Class |
|
Trading
Symbol(s) |
|
Name
of each exchange on which registered |
Common
Stock, $0.0001 par value per share |
|
PCSA |
|
The
Nasdaq Stock Market LLC |
Indicate
by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2)
has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate
by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule
405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).
Yes ☒ No ☐
Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or emerging growth company. See definition of “large accelerated filer,” “accelerated filer,” “smaller
reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large
accelerated filer |
☐ |
Accelerated
filer |
☐ |
Non-accelerated
filer |
☒ |
Smaller
reporting company |
☒ |
|
|
Emerging
growth company |
☐ |
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate
by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
The
number of outstanding shares of the registrant’s common stock at August 4, 2023 was 24,531,474.
PROCESSA
PHARMACEUTICALS, INC.
TABLE
OF CONTENTS
PART
1: FINANCIAL INFORMATION
ITEM
1: FINANCIAL STATEMENTS
Processa
Pharmaceuticals, Inc.
Condensed
Consolidated Balance Sheets
(Unaudited)
| |
June 30, 2023 | | |
December 31, 2022 | |
ASSETS | |
| | | |
| | |
Current Assets | |
| | | |
| | |
Cash and cash equivalents | |
$ | 8,677,133 | | |
$ | 6,503,595 | |
Prepaid expenses and other | |
| 1,220,150 | | |
| 1,883,134 | |
Total Current Assets | |
| 9,897,283 | | |
| 8,386,729 | |
| |
| | | |
| | |
Property and Equipment, net | |
| - | | |
| - | |
| |
| | | |
| | |
Other Assets | |
| | | |
| | |
Operating lease right-of-use assets, net | |
| 187,605 | | |
| 227,587 | |
Security deposit | |
| 5,535 | | |
| 5,535 | |
Total Other Assets | |
| 193,140 | | |
| 233,122 | |
Total Assets | |
$ | 10,090,423 | | |
$ | 8,619,851 | |
| |
| | | |
| | |
LIABILITIES AND STOCKHOLDERS’ EQUITY | |
| | | |
| | |
Current Liabilities | |
| | | |
| | |
Current maturities of operating lease liability | |
$ | 81,890 | | |
$ | 78,896 | |
Accounts payable | |
| 239,022 | | |
| 327,548 | |
Due to licensor | |
| 189,000 | | |
| 189,000 | |
Due to related parties | |
| - | | |
| 51 | |
Accrued expenses | |
| 311,502 | | |
| 403,061 | |
Total Current Liabilities | |
| 821,414 | | |
| 998,556 | |
Non-current Liabilities | |
| | | |
| | |
Non-current operating lease liability | |
| 109,327 | | |
| 150,554 | |
Total Liabilities | |
| 930,741 | | |
| 1,149,110 | |
| |
| | | |
| | |
Commitments and Contingencies | |
| - | | |
| - | |
| |
| | | |
| | |
Stockholders’ Equity | |
| | | |
| | |
Common stock, par value $0.0001, 100,000,000 shares authorized: 24,631,474 issued and 24,531,474 outstanding at June 30, 2023, and 16,135,400 issued and 16,035,400 outstanding at December 31, 2022 | |
| 2,463 | | |
| 1,614 | |
Additional paid-in capital | |
| 80,339,418 | | |
| 72,016,688 | |
Treasury stock at cost — 100,000 shares at June 30, 2023 and December 31, 2022 | |
| (300,000 | ) | |
| (300,000 | ) |
Accumulated deficit | |
| (70,882,199 | ) | |
| (64,247,561 | ) |
Total Stockholders’ Equity | |
| 9,159,682 | | |
| 7,470,741 | |
Total Liabilities and Stockholders’ Equity | |
$ | 10,090,423 | | |
$ | 8,619,851 | |
The
accompanying notes are an integral part of these condensed consolidated financial statements.
Processa
Pharmaceuticals, Inc.
Condensed
Consolidated Statements of Operations
(Unaudited)
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Operating Expenses | |
| | | |
| | | |
| | | |
| | |
Research and development expenses | |
$ | 1,688,164 | | |
$ | 3,137,292 | | |
$ | 3,342,509 | | |
$ | 5,181,912 | |
General and administrative expenses | |
| 1,026,301 | | |
| 2,034,456 | | |
| 3,477,490 | | |
| 3,218,550 | |
| |
| | | |
| | | |
| | | |
| | |
Operating Loss | |
| (2,714,465 | ) | |
| (5,171,748 | ) | |
| (6,819,999 | ) | |
| (8,400,462 | ) |
| |
| | | |
| | | |
| | | |
| | |
Other Income (Expense), net | |
| 101,900 | | |
| 7,380 | | |
| 185,361 | | |
| 8,963 | |
| |
| | | |
| | | |
| | | |
| | |
Income Tax Benefit | |
| - | | |
| - | | |
| - | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Net Loss | |
$ | (2,612,565 | ) | |
$ | (5,164,368 | ) | |
$ | (6,634,638 | ) | |
$ | (8,391,499 | ) |
| |
| | | |
| | | |
| | | |
| | |
Net Loss per Common Share - Basic and Diluted | |
$ | (0.10 | ) | |
$ | (0.32 | ) | |
$ | (0.27 | ) | |
$ | (0.53 | ) |
| |
| | | |
| | | |
| | | |
| | |
Weighted Average Common Shares Used to Compute Net Loss Applicable to Common Shares - Basic and Diluted | |
| 26,935,463 | | |
| 15,940,510 | | |
| 24,864,630 | | |
| 15,886,116 | |
The
accompanying notes are an integral part of these condensed consolidated financial statements.
Processa
Pharmaceuticals, Inc.
Condensed
Consolidated Statements of Changes in Stockholders’ Equity
(Unaudited)
| |
Shares | | |
Amount | | |
Capital | | |
Shares | | |
Amount | | |
Deficit | | |
Total | |
| |
| | |
Additional | | |
| | |
| | |
| |
| |
Common Stock | | |
Paid-In | | |
Treasury Stock | | |
Accumulated | |
| |
Shares | | |
Amount | | |
Capital | | |
Shares | | |
Amount | | |
Deficit | | |
Total | |
Balance at January 1, 2022 | |
| 15,710,246 | | |
$ | 1,571 | | |
$ | 62,306,861 | | |
| - | | |
$ | - | | |
$ | (36,823,332 | ) | |
$ | 25,485,100 | |
Stock-based compensation | |
| 103,670 | | |
| 10 | | |
| 828,887 | | |
| - | | |
| - | | |
| - | | |
| 828,897 | |
Acquisition of treasury stock | |
| - | | |
| - | | |
| - | | |
| (100,000 | ) | |
| (300,000 | ) | |
| - | | |
| (300,000 | ) |
Shares issued in connection with the Purchase Agreement with Lincoln Park | |
| 123,609 | | |
| 12 | | |
| 449,988 | | |
| - | | |
| - | | |
| - | | |
| 450,000 | |
Net loss | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| (3,227,131 | ) | |
| (3,227,131 | ) |
Balance, March 31, 2022 | |
| 15,937,525 | | |
| 1,593 | | |
| 63,585,736 | | |
| (100,000 | ) | |
| (300,000 | ) | |
| (40,050,463 | ) | |
| 23,236,866 | |
Stock-based compensation | |
| (18,208 | ) | |
| (1 | ) | |
| 2,009,370 | | |
| - | | |
| - | | |
| - | | |
| 2,009,369 | |
Net loss | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| (5,164,368 | ) | |
| (5,164,368 | ) |
Balance, June 30, 2022 | |
| 15,919,317 | | |
$ | 1,592 | | |
$ | 65,595,106 | | |
| (100,000 | ) | |
$ | (300,000 | ) | |
$ | (45,214,831 | ) | |
$ | 20,081,867 | |
| |
| | |
Additional | | |
| | |
| | |
| |
| |
Common Stock | | |
Paid-In | | |
Treasury Stock | | |
Accumulated | |
| |
Shares | | |
Amount | | |
Capital | | |
Shares | | |
Amount | | |
Deficit | | |
Total | |
Balance at January 1, 2023 | |
| 16,135,400 | | |
$ | 1,614 | | |
$ | 72,016,688 | | |
| (100,000 | ) | |
$ | (300,000 | ) | |
$ | (64,247,561 | ) | |
$ | 7,470,741 | |
Stock-based compensation | |
| 63,882 | | |
| 6 | | |
| 341,498 | | |
| - | | |
| - | | |
| - | | |
| 341,504 | |
Shares issued in connection with capital raises, net of transaction costs | |
| 8,432,192 | | |
| 843 | | |
| 6,351,234 | | |
| - | | |
| - | | |
| - | | |
| 6,352,077 | |
Net loss | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| (4,022,073 | ) | |
| (4,022,073 | ) |
Balance, March 31, 2023 | |
| 24,631,474 | | |
| 2,463 | | |
| 78,709,420 | | |
| (100,000 | ) | |
| (300,000 | ) | |
| (68,269,634 | ) | |
| 10,142,249 | |
Stock-based compensation | |
| - | | |
| - | | |
| 319,123 | | |
| - | | |
| - | | |
| - | | |
| 319,123 | |
Warrants issued in connection with consulting agreement | |
| - | | |
| - | | |
| 1,310,875 | | |
| - | | |
| - | | |
| - | | |
| 1,310,875 | |
Net loss | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| (2,612,565 | ) | |
| (2,612,565 | ) |
Balance, June 30, 2023 | |
| 24,631,474 | | |
$ | 2,463 | | |
$ | 80,339,418 | | |
| (100,000 | ) | |
$ | (300,000 | ) | |
$ | (70,882,199 | ) | |
$ | 9,159,682 | |
The
accompanying notes are an integral part of these condensed consolidated financial statements.
Processa
Pharmaceuticals, Inc.
Condensed
Consolidated Statements of Cash Flows
(Unaudited)
| |
2023 | | |
2022 | |
| |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | |
Cash Flows From Operating Activities | |
| | | |
| | |
Net loss | |
$ | (6,634,638 | ) | |
$ | (8,391,499 | ) |
Adjustments to reconcile net loss to net cash used in operating activities: | |
| | | |
| | |
Non-cash lease expense for right-of-use assets | |
| 39,982 | | |
| 45,291 | |
Non-cash milestone expense in connection with license agreement | |
| - | | |
| 189,000 | |
Amortization of issuance costs | |
| - | | |
| 40,613 | |
Amortization of intangible asset | |
| - | | |
| 394,248 | |
Stock-based compensation | |
| 660,627 | | |
| 2,838,266 | |
Warrants issued to purchase 3,160,130
shares of common stock in connection with a consulting agreement | |
| 1,310,875 | | |
| - | |
| |
| | | |
| | |
Net changes in operating assets and liabilities: | |
| | | |
| | |
Prepaid expenses and other | |
| 662,984 | | |
| 272,050 | |
Operating lease liability | |
| (38,233 | ) | |
| (47,256 | ) |
Accounts payable | |
| (88,526 | ) | |
| 429,199 | |
Due (from) to related parties | |
| (51 | ) | |
| (1,772 | ) |
Other receivables | |
| - | | |
| 70,274 | |
Accrued expenses | |
| (91,559 | ) | |
| 28,147 | |
Net cash used in operating activities | |
| (4,178,539 | ) | |
| (4,133,439 | ) |
| |
| | | |
| | |
Cash Flows From Financing Activities | |
| | | |
| | |
Net proceeds from common stock issued | |
| 6,352,077 | | |
| - | |
Acquisition of treasury stock | |
| - | | |
| (300,000 | ) |
Net cash provided by (used in) financing activities | |
| 6,352,077 | | |
| (300,000 | ) |
| |
| | | |
| | |
Net Increase (Decrease) in Cash | |
| 2,173,538 | | |
| (4,433,439 | ) |
Cash and Cash Equivalents – Beginning of Period | |
| 6,503,595 | | |
| 16,497,581 | |
Cash and Cash Equivalents – End of Period | |
$ | 8,677,133 | | |
$ | 12,064,142 | |
| |
| | | |
| | |
Non-Cash Financing Activities | |
| | | |
| | |
Issuance of 123,609 shares of common stock in connection with the Purchase Agreement with Lincoln Park | |
$ | - | | |
$ | 450,000 | |
The
accompanying notes are an integral part of these condensed consolidated financial statements.
Processa
Pharmaceuticals, Inc.
Notes
to Condensed Consolidated Financial Statements
(Unaudited)
Note
1 – Organization and Summary of Significant Accounting Policies
Organization
We
are a clinical-stage biopharmaceutical company focused on incorporating our Regulatory Science Approach into the development of our Next
Generation Chemotherapy (NGC) drugs to improve the safety and efficacy of cancer treatment. Our NGC drugs are modifications of existing
FDA-approved oncology drugs resulting in an alteration of the metabolism and/or distribution while maintaining the well-known and established
existing mechanisms of killing the cancer cells. By modifying the NGC drugs in this manner, we believe our three NGC treatments will
provide improved safety-efficacy profiles when compared to their currently marketed counterparts.
Basis
of Presentation
The
accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally
accepted in the United States of America (“U.S. GAAP”) for interim financial information and with the instructions of the
Securities and Exchange Commission (“SEC”) on Form 10-Q and Article 8 of Regulation S-X.
Accordingly,
they do not include all the information and disclosures required by U.S. GAAP for complete financial statements. All material intercompany
accounts and transactions have been eliminated in consolidation. In the opinion of management, the accompanying unaudited condensed consolidated
financial statements include all adjustments necessary, which are of a normal and recurring nature, for the fair presentation of our
financial position and of the results of operations and cash flows for the periods presented. These condensed consolidated financial
statements should be read in conjunction with the audited financial statements and notes thereto included in our Annual Report on Form
10-K for the year ended December 31, 2022, as filed with the SEC. The results of operations for the interim periods shown in this report
are not necessarily indicative of the results that may be expected for any other interim period or for the full year.
Going
Concern and Management’s Plans
We
have incurred losses since inception, devoting substantially all of our efforts toward research and development, and have an accumulated
deficit of $70.9 million at June 30, 2023. During the six months ended June 30, 2023, we generated a net loss of $6.6 million and used
$4.2 million in net cash from operating activities from continuing operations. We expect to continue to generate operating losses and
negative cash flow from operations for the foreseeable future.
During
the six months ended June 30, 2023, we raised gross proceeds of $7.0 million (net proceeds of $6.4 million) from the sale of 8,432,192
shares of our common stock, as described in Note 2. We plan to use the net proceeds from these financings to prepare for future clinical
trials; and on research and development expenses, working capital and other general corporate purposes.
Our
condensed consolidated financial statements have been prepared using U.S. GAAP and are based on the assumption that we will continue
as a going concern, which contemplates the realization of assets and liquidation of liabilities in the normal course of business. We
face certain risks and uncertainties that are present in many emerging pharmaceutical companies regarding product development,
limited working capital, recurring losses and negative cash flow from operations, future profitability, ability to obtain future capital,
protection of patents, technologies and property rights, competition, rapid technological change, navigating the domestic and major foreign
markets’ regulatory and clinical environment, recruiting and retaining key personnel, dependence on third party manufacturing organizations,
third party collaboration and licensing agreements, lack of sales and marketing activities. We currently have no customers or pharmaceutical
products to sell or distribute. These risks and other factors raise substantial doubt about our ability to continue as a going concern.
At
June 30, 2023, we had cash and cash equivalents totaling $8.7
million. Based on our current plans, we believe our current cash balances will enable us to complete our current clinical trial in
NGC-Capecitabine (also known as PCS6422), prepare for future clinical trials, fund our administrative costs through the second
quarter of 2024, and close out the PCS499 and PCS12852 trials. Our ability to execute our longer-term operating plans, including
future clinical trials for our NGC drugs, will depend on our ability to obtain additional funding from the
sale of equity and/or debt securities, a strategic transaction or other funding transactions. We plan to continue to actively pursue
financing alternatives, including out-licensing and/or entering into partnerships on any of our non-core assets, but there can be no
assurance that we will obtain the necessary funding in the future when necessary.
We
had no revenue during the six months ended June 30, 2023 and do not have any revenue under contract or any immediate sales prospects.
Our primary uses of cash are to fund our planned clinical trials, research and development expenditures and other operating expenses.
Cash used to fund operating expenses is impacted by the timing of when we incur and pay these expenses.
We
are hoping to raise additional funds in 2023, but will only do so if terms are acceptable to us. Additional funding may not be
available to us on acceptable terms, or at all. If we are unable to obtain adequate financing when needed, we may have to delay,
reduce the scope of, or suspend our current or planned future clinical trial plans, or research and development programs. We may
seek to raise any necessary additional capital through a combination of public or private equity offerings, debt financings,
collaborations, strategic alliances, licensing arrangements and other marketing and distribution arrangements. To the extent that we
raise additional capital through marketing and distribution arrangements or other collaborations, strategic alliances or licensing
arrangements with third parties, we may have to relinquish valuable rights to our product candidates, future revenue streams,
research programs or product candidates or to grant licenses on terms that may not be favorable to us. If we raise additional
capital through public or private equity offerings, the ownership interest of our existing stockholders will be diluted, and the
terms of these securities may include liquidation or other preferences that adversely affect our stockholders’ rights. If we
raise additional capital through debt financing, we may be subject to covenants limiting or restricting our ability to take specific
actions, such as incurring additional debt, making capital expenditures or declaring dividends.
Uncertainty
concerning our ability to continue as a going concern may hinder our ability to obtain future financing. Continued operations and our
ability to continue as a going concern are dependent on our ability to obtain additional funding in the future and thereafter, and no
assurances can be given that such funding will be available at all, in a sufficient amount, or on reasonable terms. Without additional
funds from debt or equity financing, sales of assets, sales or out-licenses of intellectual property or technologies, or other transactions
providing funds, we will rapidly exhaust our resources and be unable to continue operations. Absent additional funding, we believe that
our cash and cash equivalents will not be sufficient to fund our operations for a period of one year or more after the date that these
condensed consolidated financial statements are available to be issued based on the timing and amount of our projected net loss from
continuing operations and cash to be used in operating activities during that period of time.
As
a result, substantial doubt exists about our ability to continue as a going concern within one year after the date that these condensed
consolidated financial statements are available to be issued. The accompanying condensed consolidated financial statements do not include
any adjustments to reflect the possible future effects on the recoverability and classification of recorded assets, or the amounts and
classification of liabilities that might be different should we be unable to continue as a going concern based on the outcome of these
uncertainties described above.
Use
of Estimates
In
preparing our condensed consolidated financial statements and related disclosures in conformity with U.S. GAAP and pursuant to the rules
and regulations of the SEC, we make estimates and judgments that affect the amounts reported in the condensed consolidated financial
statements and accompanying notes. Estimates are used for, but not limited to preclinical and clinical trial expenses, stock-based compensation,
intangible assets, future milestone payments and income taxes. These estimates and assumptions are continuously evaluated and are based
on management’s experience and knowledge of the relevant facts and circumstances. While we believe the estimates to be reasonable,
actual results could differ materially from those estimates and could impact future results of operations and cash flows.
Income
Taxes
We
account for income taxes in accordance with ASC Topic 740, Income Taxes. Deferred income taxes are recorded for the expected tax
consequences of temporary differences between the basis of assets and liabilities for financial reporting purposes and amounts recognized
for income tax purposes. At June 30, 2023 and December 31, 2022, we recorded a valuation allowance equal to the full recorded amount
of our net deferred tax assets since it is more-likely-than-not that such benefits will not be realized. The valuation allowance is reviewed
quarterly and is maintained until sufficient positive evidence exists to support its reversal.
Under
ACS 740-270 Income Taxes – Interim Reporting, we are required to project our annual federal and state effective income tax
rate and apply it to the year-to-date ordinary operating tax basis loss before income taxes. Based on the projection, no current income
tax benefit or expense is expected for 2023 and the foreseeable future since we expect to generate taxable net operating losses.
Concentration
of Credit Risk
Financial
instruments that potentially subject us to significant concentration of credit risk consist primarily of our cash and cash equivalents.
We utilize only well-established banks and financial institutions with high credit ratings. Balances on deposit are insured by the Federal
Deposit Insurance Corporation (FDIC) up to specified limits. Total cash held by our banks at June 30, 2023, exceeded FDIC limits.
Recent
Accounting Pronouncements
From
time to time, the Financial Accounting Standards Board (“FASB”) or other standard setting bodies issue new accounting pronouncements.
Updates to the FASB Accounting Standards Codification are communicated through issuance of an Accounting Standards Update (“ASU”).
We have implemented all new accounting pronouncements that are in effect and that may impact our condensed consolidated financial statements.
We have evaluated recently issued accounting pronouncements and determined that there is no material impact on our consolidated financial
position or results of operations.
Note
2 – Stockholders’ Equity
Preferred
Stock
There
were no issued or outstanding shares of preferred stock at either June 30, 2023 or December 31, 2022.
Common
Stock
Increase in Our Authorized Number of Shares
Subsequent to receiving shareholder approval on June 27, 2023, we amended
our Certificate of Incorporation to increase the number of authorized shares of our common stock from 50,000,000 to 100,000,000. We believe
100,000,000 authorized shares of common stock better aligns our capital structure with our future needs and have shown this retroactively
in the condensed consolidated financial statements.
During
the six months ended June 30, 2023, we issued 8,432,192
shares of our common stock through several fundraising
efforts described below:
ATM
Offering
On
August 20, 2021, we entered into the Sales Agreement with Oppenheimer & Co. Inc. (the “Sales Agent”) under which we may
issue and sell up to $30.0 million from time to time under the ATM Offering. We expect to use net proceeds from the ATM Offering over
time as a source for working capital and general corporate purposes. During the six months ended June 30, 2023, we sold 569,648 shares
at an average price of $1.22 per share for aggregate gross proceeds of $693,000 (net proceeds of $672,000) prior to deducting sales commissions.
On February 5, 2023, in connection with our Registered Direct Offering, we suspended the Sales Agreement with the Sales Agent, but we
expect to reinstate it in the future.
Lincoln
Park Capital Fund, LLC Purchase Agreement
On
March 23, 2022, we entered into the Purchase Agreement with Lincoln Park, pursuant to which Lincoln Park has committed to purchase up
to $15.0 million of shares (the “Purchase Shares”) of our common stock, subject to the terms and conditions in the Purchase
Agreement with Lincoln Park, including that the closing sale price of the common stock on the purchase date is not below a threshold
price of $1.00. Any proceeds that we receive under the Purchase Agreement are expected to be used for working capital and general corporate
purposes. During the six months ended June 30, 2023, we sold 50,000 shares at an average price of $1.08 per share for aggregate gross
proceeds of $54,000 under the Purchase Agreement with Lincoln Park.
Registered
Direct Offering
On
February 14, 2023, we closed a registered direct offering (the “Offering”) for the sale of 7,812,544 shares of common stock
at a purchase price of $0.80 per share for gross proceeds of $6.3 million (net proceeds of $5.6 million). The Purchase Agreement provides
that, subject to certain exceptions, until the earlier of (i) 90 days after the closing of the Offering or (ii) the trading day following
the date that our common stock’s closing price exceeds $2.00 for a period of 10 consecutive trading days, neither we nor our subsidiary
will issue or enter into any agreement to issue or announce the issuance or proposed issuance of any shares of common stock or common
stock equivalents.
We
paid the Placement Agent (“Spartan Capital” or “Spartan”) a cash fee of 8.0% of the gross proceeds from the Offering, excluding proceeds received from our insiders, and
reimbursed the Placement Agent for legal fees of $60,000. The engagement agreement with the Placement Agent requires us to indemnify
the Placement Agent and certain of its affiliates against certain customary liabilities. On February 14, 2023, we amended our consulting
agreement with Spartan originally entered into on August 24, 2022, extending the term of the consulting agreement until February 10,
2024. As compensation for services under the agreement, on April 17, 2023, we granted Spartan warrants to purchase 3,160,130 shares
of our common stock with an exercise price of $1.02. The warrants will expire three years from the date of issuance and contains both
call and cashless exercise provisions.
Note
3 - Stock-based Compensation
On
June 19, 2019, our stockholders approved, and we adopted the Processa Pharmaceuticals Inc. 2019 Omnibus Equity Incentive Plan (the “2019
Plan”). The 2019 Plan allows us, under the direction of our Board of Directors or a committee thereof, to make grants of stock
options, restricted and unrestricted stock and other stock-based awards to employees, including our executive officers, consultants and
directors. The 2019 Plan provides for the aggregate issuance of 6,000,000 shares of our common stock. At June 30, 2023, we had 931,692
shares available for future grants.
Stock
Compensation Expense
We
recorded stock-based compensation expense for the three and six months ended June 30, 2023 and 2022 as follows:
Schedule
of Stock-based Compensation Expense
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Research and development | |
$ | 102,678 | | |
$ | 685,624 | | |
$ | 209,526 | | |
$ | 877,500 | |
General and administrative | |
| 216,445 | | |
| 1,323,745 | | |
| 451,101 | | |
| 1,960,766 | |
Total | |
$ | 319,123 | | |
$ | 2,009,369 | | |
$ | 660,627 | | |
$ | 2,838,266 | |
During
the six months ended June 30, 2023, we also recorded an expense of $1.3
million related to the warrants we issued to Spartan (see Note 2), which is not included in the table above. No tax benefits were attributed to
the stock-based compensation expense because a valuation allowance was maintained for all net deferred tax assets relating to this
expense.
Stock
Options
During
the six months ended June 30, 2023, stock options to purchase 36,885 shares of common stock expired and there were no exercises or grants
of stock options. At June 30, 2023, we had outstanding and exercisable options for the purchase of 141,611 shares with a weighted average
exercise price of $18.22, a weighted average remaining contractual life of 2.6
years. At June 30, 2023, we did not have any unrecognized stock-based compensation expense
related to our granted stock options.
Restricted
Stock Awards
Activity
with respect to our Restricted Stock Awards (RSAs) during the six months ended June 30, 2023 was as follows:
Schedule
of Restricted Stock Awards (“RSAs”) Activity
| |
Number of shares | | |
Weighted- average grant-date fair value per share | |
Outstanding at January 1, 2023 | |
| 61,888 | | |
$ | 4.72 | |
Granted | |
| 90,000 | | |
| 1.10 | |
Cancelled | |
| (26,118 | ) | |
| 1.72 | |
Issued | |
| (100,770 | ) | |
| 1.79 | |
| |
| | | |
| | |
Outstanding and unvested at June 30, 2023 | |
| 25,000 | | |
$ | 6.65 | |
On
January 1, 2023, we granted RSAs totaling 90,000 shares of common stock to three directors for their service for the six-month period
ending June 30, 2023 in order to align their compensation plan with their service period and change the annual service period to begin
and end on the date of respective Annual Meetings rather than the calendar year. Our directors are compensated through a combination
of cash and equity. On March 8, 2023, the directors increased the cash component and decreased the equity component of their compensation
by equal amounts on a retroactive basis, to the beginning of their respective service periods. Accordingly, we cancelled RSAs representing
26,118 shares of common stock.
At
June 30, 2023, the total unrecognized stock-based compensation expense related to the outstanding and unvested RSAs was $94,000,
which is expected to be recognized over a weighted average period of 1.3
years. The weighted-average grant-date fair value of RSAs granted during the six
months ended June 30, 2022 was $4.21.
Restricted
Stock Units
Activity
with respect to our Restricted Stock Units (“RSUs”) during the six months ended June 30, 2023 was as follows:
Schedule
of Restricted Stock Units (“RSUs”) Activity
| |
Number of shares | | |
Weighted- average grant-date fair value per share | |
Outstanding at January 1, 2023 | |
| 2,713,977 | | |
$ | 3.69 | |
Granted | |
| 1,473,328 | | |
| 0.90 | |
Cancelled | |
| (44,395 | ) | |
| 1.63 | |
Outstanding at June 30, 2023 | |
| 4,142,910 | | |
| 2.72 | |
Vested and unissued | |
| 2,590,497 | | |
| 3.51 | |
| |
| | | |
| | |
Unvested at June 30, 2023 | |
| 1,552,413 | | |
$ | 1.41 | |
At
June 30, 2023, unrecognized stock-based compensation expense of $1.2 million for RSUs is expected to be fully recognized over a weighted
average period of 1.5 years. The unrecognized expense excludes $322,000 of expense related to certain RSUs with a performance milestone
that is not probable of occurring at this time. The weighted-average grant-date fair value of RSUs granted during the six months ended June 30, 2022 was $3.01.
Holders
of our vested RSUs have our promise to issue shares of our common stock upon meeting the distribution restrictions contained in their
Restricted Stock Unit Award Agreement. The distribution restrictions are different (longer) than the vesting schedule, imposing an additional
restriction on the holder. Unlike RSAs, while certain employees may hold fully vested RSUs, the individual does not hold any shares or
have any rights of a shareholder until the distribution restrictions are met. Upon distribution to the employee, each RSU converts into
one share of our common stock. The RSUs contain dividend equivalent rights.
Warrants
During
the six months ended June 30, 2023, we granted warrants to purchase a total of 3,160,130 shares
of our common stock as compensation for services provided under an amended consulting agreement with Spartan Capital, the placement
agent for the Offering. The warrants were issued and
exercisable on April 17, 2023 with an exercise price of $1.02 and
expiration date of April 17, 2026. The warrants contains both call and cashless exercise provisions. We recorded $1,310,875 as
a general and administrative expense representing the fair value of these warrants on February 14, 2023, the date we amended the
consulting agreement since there were no contingent conditions on that date through April 17, 2023, the date of issuance. At
June 30, 2023, we had outstanding and exercisable stock purchase warrants for the purchase of 3,366,480 shares
with a weighted average exercise price of $1.61 and
a weighted average remaining contractual life of 2.5 years.
At
June 30, 2023, we did not have any unrecognized stock-based compensation expense related to our granted stock purchase warrants.
Note
4 – Net Loss per Share of Common Stock
Net
Loss Per Share
Basic
net loss per share is computed by dividing our net loss available to common shareholders by the weighted average number of shares of
common stock outstanding (which excludes unvested RSAs and includes vested RSUs) during the period. Diluted loss per share is
computed by dividing our net loss available to common shareholders by the diluted weighted average number of shares of common stock
(which includes the potentially dilutive effect of stock options, unvested RSAs, unvested RSUs and warrants) during the period.
Since we experienced a net loss for both periods presented, basic and diluted net loss per share are the same. As such, diluted loss
per share for the three and six months ended June 30, 2023 and 2022 excludes the impact of potentially dilutive common shares since
those shares would have an anti-dilutive effect on net loss per share.
The
computation of net loss per share for the three- and six-month periods ended June 30, 2023 and 2022 was as follows:
Schedule
of Net Loss Per Share Basic and Diluted
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Basic and diluted net loss per share: | |
| | | |
| | | |
| | | |
| | |
Net loss available to common stockholders | |
$ | (2,612,565 | ) | |
$ | (5,164,368 | ) | |
$ | (6,634,638 | ) | |
$ | (8,391,499 | ) |
Weighted average number of common shares-basic and diluted | |
| 26,935,463 | | |
| 15,940,510 | | |
| 24,864,630 | | |
| 15,886,116 | |
| |
| | | |
| | | |
| | | |
| | |
Basic and diluted net loss per share | |
$ | (0.10 | ) | |
$ | (0.32 | ) | |
$ | (0.27 | ) | |
$ | (0.53 | ) |
Our
diluted net loss per share for the three and six months ended June 30, 2023 and 2022 excluded 5,085,504 and 1,965,502 of potentially
dilutive common shares, respectively, related to outstanding stock options, warrants and unvested restricted stock since those shares
would have had an anti-dilutive effect on net loss per share during the periods then ended.
Note
5 – Operating Leases
We
lease our office space under an operating lease agreement. This lease does not have significant rent escalation, concessions, leasehold
improvement incentives, or other build-out clauses. Further, the lease does not contain contingent rent provisions. Our office space
lease includes both lease (e.g., fixed payments including rent, taxes, and insurance costs) and non-lease components (e.g., common-area
or other maintenance costs), which are accounted for as a single lease component as we have elected the practical expedient to group
lease and non-lease components for all leases. We also lease office equipment under an operating lease. Our leases do not provide an
implicit rate and, as such, we have used our incremental borrowing rate of 8% to determine the present value of the lease payments
based on the information available at the lease commencement date.
Lease
costs included in our condensed consolidated statements of operations totaled $24,000
for both three-month periods ended June 30, 2023 and 2022 and $49,000
for both six-month periods ended June 30, 2023 and 2022. The weighted average remaining lease terms and discount rate for
our operating leases were as follows at June 30, 2023:
Schedule
of Weighted Average Remaining Lease Terms and Discount Rate for Operating Leases
Remaining lease term (years) for our facility lease | |
| 2.3 | |
Remaining lease term (years) for our equipment lease | |
| 0.8 | |
Weighted average remaining lease term (years) for our facility and equipment leases | |
| 2.2 | |
Weighted average discount rate for our facility and equipment leases | |
| 8.0 | % |
Annual
lease liabilities for all operating leases were as follows at June 30, 2023:
Schedule
of Annual Lease Liabilities for all Operating Leases
| |
| | |
2023 | |
$ | 47,354 | |
2024 | |
| 92,356 | |
2025 | |
| 70,040 | |
Total lease payments | |
| 209,750 | |
Less: Interest | |
| (18,533 | ) |
Present value of lease liabilities | |
| 191,217 | |
Less: current maturities | |
| (81,890 | ) |
Non-current lease liability | |
$ | 109,327 | |
Note
6 – Related Party Transactions
CorLyst,
LLC (“CorLyst”) reimburses us for shared costs related to payroll, health insurance and rent based on actual costs
incurred, which are recognized as a reduction of our general and administrative operating expenses being reimbursed in our condensed
consolidated statement of operations. We recorded $34,000
and $32,000
of reimbursements during the three months ended June 30, 2023 and 2022, respectively, and $64,000
for both six-month periods ended June 30, 2023 and 2022. No
amounts were due from CorLyst at June 30, 2023 or 2022. Dr. David Young is the CEO of CorLyst, and CorLyst is a shareholder.
Note
7 – Commitments and Contingencies
Purchase
Obligations
We
enter into contracts in the normal course of business with contract research organizations (CROs) and subcontractors to further develop
our products. The contracts are cancelable, with varying provisions regarding termination. If we terminated a cancelable contract with
a specific vendor, we would only be obligated for products or services that we received at the effective date of the termination and
any applicable cancellation fees. At June 30, 2023, we are contractually obligated to pay up to $2.4 million of future services under
the agreements with the CROs. Our actual contractual obligations will also vary depending on the progress and results of the remaining
clinical trials.
Note 8 – Subsequent
Event
On August
8, 2023, Mr. George Ng was appointed as our Chief Executive Officer and as a Board Director. Mr. Ng is a seasoned life sciences industry
executive with significant experience successfully leading small-cap public companies including through product development and fundraising
activities. In connection with his employment, Mr. Ng will be paid an annual base salary of $400,000 and will be eligible to receive bonus
compensation of up to $100,000 contingent on Mr. Ng. meeting certain performance milestones during 2023 and 2024. In addition, the Compensation
Committee awarded 800,000 restricted stock units (“RSUs”) to Mr. Ng. Vesting for 400,000 RSUs occurs ratably over a three-year
period. The remaining 400,000 RSUs will vest on the achievement of certain performance metrics, with the first 200,000 performance-based
RSUs vesting when gross proceeds of $10,000,000 is raised, and the second 200,000 performance-based RSUs vesting when additional gross
proceeds of $10,000,000 is raised. He will also be eligible for other benefits as described in the Employment Agreement.
Given his oncology and
drug development expertise, Dr. David Young will transition to be our President, Research and Development, concentrating his
fulltime effort to drug development of our NGC drugs. By mutual agreement, Mr. R. Michael Floyd resigned as Chief Operating Officer
of the Company, effective August 31, 2023.
Item
2. Management’s Discussion and Analysis of Financial Condition and Results of Operation
Forward
Looking Statements
This
Quarterly Report on Form 10-Q contains “forward-looking statements” that reflect, when made, the Company’s expectations
or beliefs concerning future events that involve risks and uncertainties. Forward-looking statements frequently are identified by the
words “believe,” “anticipate,” “expect,” “estimate,” “intend,” “project,”
“will be,” “will continue,” “will likely result,” or other similar words and phrases. Similarly,
statements herein that describe the Company’s objectives, plans or goals also are forward-looking statements. Actual results could
differ materially from those projected, implied or anticipated by the Company’s forward-looking statements. Some of the factors
that could cause actual results to differ include: our limited operating history, limited cash and history of losses; our ability to
achieve profitability; our ability to obtain adequate financing to fund our business operations in the future; the impact of COVID-19,
including its impact on our ability to obtain financing or complete clinical trials; our ability to secure required FDA or other governmental
approvals for our product candidates and the breadth of the indication sought; the impact of competitive or alternative products, technologies
and pricing; whether we are successful in developing and commercializing our technology, including through licensing; the adequacy of
protections afforded to us and/or our licensors by the anticipated patents that we own or license and the cost to us of maintaining,
enforcing and defending those patents; our and our licensors’ ability to protect non-patented intellectual property rights; our
exposure to and ability to defend third-party claims and challenges to our and our licensors’ anticipated patents and other intellectual
property rights; and our ability to continue as a going concern. For a discussion of these and all other known risks and uncertainties
that could cause actual results to differ from those contained in the forward-looking statements, see “Risk Factors” in the
Company’s Annual Report on Form 10-K for the year ended December 31, 2022, which is available on the SEC’s website at www.sec.gov.
All forward-looking statements are qualified in their entirety by this cautionary statement, and the Company undertakes no obligation
to revise or update this Quarterly Report on Form 10-Q to reflect events or circumstances after the date hereof.
For
purposes of this Management’s Discussion and Analysis of Financial Condition and Results of Operations, references to the “Company,”
“we,” “us” or “our” refer to the operations of Processa Pharmaceuticals, Inc. and its direct and
indirect subsidiaries for the periods described herein.
Overview
We
are a clinical-stage biopharmaceutical company focused on utilizing our Regulatory Science Approach, including the principles associated
with FDA’s Project Optimus Oncology initiative and the related FDA Draft Guidance, in the development of Next Generation Chemotherapy
(NGC) oncology drug products. Our mission is to provide better treatment options than those that presently exist by extending a patient’s
survival and/or improving a patient’s quality of life. This is achieved by improving upon FDA-approved, widely used oncology drugs
or the cancer-killing metabolites of these drugs by altering how they are metabolized and/or distributed in the body, including how they
are distributed to the actual cancer cells.
Regulatory
science was conceived in the early 1990s when the founders of Processa and other faculty at the University of Maryland worked with the
FDA to develop multiple FDA Guidance documents. Over the last 30 years, two of our founders, Dr. David Young and Dr. Sian Bigora, have
expanded the original regulatory science concept to include other factors, such as the principles of Project Optimus, which can affect
the risk-benefit analyses that FDA conducts for every FDA drug approval. In fact, the principles of FDA’s Project Optimus have
been used by Drs. Young and Bigora to identify and justify an “optimal” dosage regimen for a number of non-oncology FDA-approved
drugs. Our Regulatory Science Approach and our experience with the principles of Project Optimus differentiates us from other biotechnology
companies by focusing us not only on the clinical science, but also on the equally important regulatory process. We believe utilizing
our Regulatory Science Approach provides us with three distinct advantages:
|
● |
greater
efficiencies (e.g., the right trial design and trial readouts); |
|
● |
greater
possibility of drug approval by the FDA or other regulatory authorities; and |
|
● |
improvement
over existing therapy with greater acceptance by patients/prescribers. |
In
January 2023, we announced our strategic prioritization to advance our pipeline of Next Generation Chemotherapy proprietary small molecule
oncology drugs. By changing either the metabolism, distribution and/or elimination of already FDA-approved cancer drugs or their active
metabolites while maintaining the mechanism of how the drug kills cancer cells, we believe our NGC treatments will provide improved safety-efficacy
profiles when compared to their currently marketed counterparts - capecitabine, gemcitabine, and irinotecan. All future studies of these
drugs are subject to availability of capital to conduct the trials.
The
three NGC treatments in our pipeline are as follows:
|
● |
NGC-Capecitabine
is a combination of PCS6422 and capecitabine. NGC-Capecitabine alters the metabolism of capecitabine without having any clinically
meaningful biological effect itself. In clinical trials, NGC-Capecitabine has a safety profile different than capecitabine when administered
alone. Side effects, such as Hand-Foot Syndrome (HFS) and cardiotoxicity that typically occur in up to 50-70% of patients treated
with capecitabine and caused by specific capecitabine metabolites that are not formed to the same extent with NGC-Capecitabine, do
not appear to be side effects associated with NGC-Capecitabine. These types of toxicities frequently result in decreased doses, interrupted
doses or discontinuation of treatment with capecitabine. In addition, NGC-Capecitabine has been found to be 50 times more potent
than capecitabine based on the systemic exposure of the capecitabine metabolite 5-FU, which is metabolized to the cancer-killing
metabolites. Like capecitabine, NGC-Capecitabine could be used to treat patients with various cancers, such as metastatic colorectal,
gastrointestinal, breast, and pancreatic. We estimate at least 200,000 patients in the United States were diagnosed in 2022 with
metastatic colorectal, gastrointestinal, breast, and pancreatic cancers. |
|
● |
NGC-Gemcitabine,
also identified as PCS3117, is an oral analog of gemcitabine that is converted to its active metabolite by a different enzyme system
than gemcitabine resulting in a positive response in gemcitabine patients as well as some gemcitabine treatment-resistant patients.
Like gemcitabine, NGC-Gemcitabine could be used to treat patients with various cancers such as pancreatic, lung, ovarian, and breast.
We estimate at least 275,000 patients in the United States were diagnosed in 2022 with pancreatic, lung, ovarian, and breast cancer.
We plan to meet with the FDA in 2023 to discuss potential study designs including implementation of the Project Optimus initiative
as part of the design, and then submit the Phase 2B protocol to the Investigational New Drug (IND Application) in the first half
of 2024. |
|
|
|
|
● |
NGC-Irinotecan,
also identified as PCS11T, is a prodrug of the active metabolite of irinotecan (SN-38). The chemical structure of NGC-Irinotecan
influences the uptake of the drug into cancer cells, resulting in more NGC-Irinotecan entering cancer cells than normal cells in
mice. These levels were significantly greater than those seen with irinotecan, resulting in lower doses of NGC-Irinotecan having
greater efficacy than irinotecan and improved safety in animal models. Like irinotecan, NGC-Irinotecan could be used to treat patients
with various cancers such as lung, colorectal, gastrointestinal, and pancreatic cancer. We estimate at least 200,000 patients in
the United States were diagnosed in 2022 with lung, colorectal, gastrointestinal, and pancreatic cancer. We plan to conduct IND-enabling
and toxicology studies in 2023 and 2024. |
We
have completed our Phase 2A trial for PCS12852 in gastroparesis patients with positive results. Additionally, due primarily to the
inability to identify and enroll patients in our rare disease Phase 2 trial for PCS499 in ulcerative Necrobiosis Lipoidica (uNL), we
decided to cease further enrollment in the PCS499 trial in February 2023 and terminated the trial. We did not experience any safety concerns during the
conduct of either the PCS12852 or PCS499 trial. We are currently evaluating options to monetize these non-core drug assets.
Our
shift in prioritization to NGC oncology drugs does not change our mission. We continue to be focused on drug products that improve the
survival and/or quality of life for patients by improving the safety and/or efficacy of the drug in a targeted patient population, while
providing a more efficient and probable path to FDA approval, and differentiating our drugs from those on the market or are currently
being developed.
Historically,
much of oncology drug development has searched for novel or different ways to treat cancer. Our approach is to modify and improve three
different and well-known, currently approved, and successfully used chemotherapy treatments so that the human body metabolizes and/or
distributes these NGC treatments differently than their presently approved counterpart drugs while maintaining the cancer-killing mechanism
of action. FDA’s newly issued Project Optimus Oncology initiative and draft guidance on determining the optimal dose for oncology
drugs recommends that the dose-response (both safety and efficacy) relationships be evaluated for all oncology drugs. Our Regulatory
Science Approach, developed over the last 30 years, is very well aligned with the principles of Project Optimus and draft guidance where
the objective is to identify the optimal dosage regimen, rather than the old approach of identifying the maximum tolerated dose (MTD)
and adjust dosing accordingly. To date, we have data that suggests our NGC treatments are likely to have a better safety-efficacy profile
than the current widely used marketed counterpart drugs, not only potentially making the development and approval process more efficient,
but also clearly differentiating our NGC treatments from the existing treatment. We believe our NGC treatments have the potential to
extend the survival and/or quality of life for more patients diagnosed with cancer while decreasing the number of patients who are required
to dose-adjust or discontinue treatment because of side effects or lack of response.
Our
Strategy
Our
strategy is to develop our pipeline of Next Generation Chemotherapy (NGC) proprietary small molecule oncology drugs using our Regulatory
Science Approach, encompassing the principles of the FDA’s recent Project Optimus initiative and draft guidance on determining
the optimal dosage regimen of oncology drugs.
By
changing either the metabolism, distribution, and/or elimination of already FDA-approved cancer drugs or their active metabolites while
maintaining the mechanism of how the drug kills cancer cells, we believe our three NGC treatments will provide improved safety-efficacy
profiles when compared to their currently marketed counterparts - capecitabine, gemcitabine, and irinotecan. By combining these modified
approved cancer treatments with our Regulatory Science Approach and our experience using the principles of FDA’s Project Optimus
initiative, we will be able to increase the probability of FDA approval, improve the safety-efficacy profile over their existing counterparts
which is important to patients and prescribers, and more efficiently develop each drug.
Our
pipeline of NGCs (i) already has data demonstrating the desired pharmacological activity in humans or appropriate animal models and is
able to provide improved safety and/or efficacy by some modification in the formation and/or distribution of the active moieties associated
with the drug and (ii) targets cancers for which a single positive pivotal trial demonstrating efficacy might provide enough evidence
that the clinical benefits of the drug and its approval outweighs the risks associated with the drug.
Our
Drug Pipeline
Our
pipeline currently consists of NGC-Capecitabine, NGC-Gemcitabine and NGC-Irinotecan (also identified as PCS6422, PCS3117 and PCS11T,
respectively) and two non-oncology drugs (PCS12852 and PCS499). A timeline and summary of each drug is provided below.
Next
Generation Chemotherapy Pipeline
|
● |
Next
Generation Capecitabine (NGC-Capecitabine), also identified as PCS6422, is a combination of PCS6422 and the FDA-approved cancer drug
capecitabine. PCS6422 is an orally administered irreversible inhibitor of the enzyme dihydropyrimidine dehydrogenase (DPD). DPD metabolizes
5-Fluorouracil (5-FU), the major metabolite of capecitabine and widely used itself as an intravenous chemotherapeutic agent in many
types of cancer, to multiple metabolites classified as catabolites. These catabolites do not have any cancer-killing properties but
frequently cause dose-limiting side effects that may require dose adjustments or discontinuation of therapy.
When
combining capecitabine with PCS6422 in NGC-Capecitabine, PCS6422 significantly changes the metabolism and distribution of 5-FU. After
formation from capecitabine, 5-FU is metabolized to anabolites (which kill both cancer cells and normal duplicating cells) and catabolites
(which cause side effects and have no cancer killing properties). Due to this change in metabolism of capecitabine and the change in
the overall metabolite profile of anabolites and catabolites, the side effect and efficacy profile of NGC-Capecitabine has been found
to be different than the existing FDA-approved capecitabine. Since the potency of NGC-Capecitabine is also more potent than FDA-approved
capecitabine based on the 5-FU systemic exposure per mg of capecitabine administered, the amount of capecitabine anabolites formed from
1 mg of capecitabine administered in NGC-Capecitabine will, therefore, be much greater than formed from the administration of 1 mg of
existing capecitabine.
|
|
|
On
August 2, 2021, we enrolled the first patient in our Phase 1B dose-escalation maximum tolerated dose trial in patients with advanced
refractory gastrointestinal (GI) tract tumors. Our interim analysis of Cohorts 1 and 2A of the ongoing clinical trial found no dose-limiting
toxicities (DLTs), no drug-related adverse events greater than Grade 1, and no adverse events associated with the catabolites of 5-FU
such as HFS. In this Phase 1B trial, it was demonstrated that the irreversible inhibition of DPD by PCS6422 could alter the metabolism,
distribution and elimination of 5-FU, making NGC-Capecitabine significantly more potent than capecitabine alone (50 times more potent)
and potentially leading to higher levels of anabolites which can kill replicating cancer and normal cells. By administering NGC-Capecitabine
to cancer patients, the balance between anabolites and catabolites changes depending on the dosage regimens of PCS6422 and capecitabine
used, making the efficacy-safety profile of NGC-Capecitabine different than that of FDA-approved capecitabine and requiring further evaluation
of the PCS6422 and capecitabine regimens to determine the optimal NGC-Capecitabine regimens for patients. |
|
|
|
|
|
In
order for NGC-Capecitabine to provide a safer and more efficacious profile for cancer patients compared to existing chemotherapy,
understanding how the different regimens of PCS6422 and capecitabine may affect the systemic and tumor exposure to the anabolites,
as well as the systemic exposure to the catabolites, is required. This can be achieved by following the timeline of DPD irreversible
inhibition and the formation of new DPD using the plasma concentrations of 5-FU and its catabolites. |
|
|
In
an effort to better estimate the timeline of DPD inhibition and formation of new DPD, we modified the protocol for the Phase 1B trial
and began enrolling patients in the amended Phase 1B trial in April 2022. On November 1, 2022, we announced that data from the Phase
1B trial identified multiple dosage regimens with potentially better safety and efficacy profiles than currently existing chemotherapy
regimens. Since 5-FU exposure is dependent on both the PCS6422 regimen and the capecitabine regimen, safe regimens were identified
as well as regimens that cause DLTs. One of the regimens in the Phase 1B trial did cause DLTs in two patients, one of whom died.
The Phase 1B trial is continuing to enroll patients and is expected to complete enrollment in 2023. The next trial will be a Phase
2 trial to determine which regimens provide an improved efficacy-safety profile over present therapy using the principles of the
FDA’s Project Optimus initiative to help guide the design of the trial. This FDA initiative requires us to consider NGC regimens
that are not at the maximum tolerated dose or exposure level.
Discussions
with the FDA in April 2023 have clarified that the major goal for the next Phase 2 trial will be to evaluate and understand the
dose- and exposure-response relationship for anti-tumor activity and safety. The specific dosage regimens for the trial will be
defined following the determination of the MTD from our ongoing Phase 1B trial. We recently completed Cohort 3 in the Phase 1B
trial, which dosed patients with PCS6422 in combination with capecitabine at 150 mg BID (twice a day), with no dose-limiting
toxicities. Enrollment is now complete for Cohort 4, although the initial safety evaluation for
this cohort is still ongoing. The last cohort of the study is expected to enroll in the fourth quarter of 2023. As a result of the data from the Phase 1B study and recent discussions
with the FDA, we have begun Phase 2 trial preparation tasks and will collaborate with the FDA to further define the dosage regimens
and final design prior to the trial. We will need to obtain additional funding before we can conduct this trial. |
|
● |
NGC-Gemcitabine,
also identified as PCS3117, is a cytidine analog similar to gemcitabine (Gemzar®), but different enough in chemical structure
that some patients are more likely to respond to PCS3117 than gemcitabine. The difference in response occurs because NGC-Gemcitabine
is metabolized to its active metabolite through a different enzyme system than gemcitabine. We continue to evaluate the potential
use of NGC-Gemcitabine in patients with pancreatic cancer and to evaluate ways to identify patients who are more likely to respond
to NGC-Gemcitabine than gemcitabine. We plan to meet with the FDA in 2023 to discuss potential trial designs including implementation
of the Project Optimus initiative as part of the design and then submit the Phase 2B protocol to the IND. Similar to NGC-Capecitabine, we will need to obtain additional funding
before we can begin the Phase 2B trial for NGC-Gemcitabine. |
|
|
|
|
● |
NGC-Irinotecan,
also identified as PCS11T, is an analog of SN38 (SN38 is the active metabolite of irinotecan) and should have an improved safety/efficacy
profile in every type of cancer that irinotecan is presently used. The manufacturing process and sites for drug substance and drug
product are presently being evaluated and IND-enabling toxicology studies will then be initiated. In addition, we are defining the
potential paths to approval, which include defining the targeted patient population and the type of cancer. We plan to conduct IND
enabling and toxicology studies in 2023 and 2024, subject to available funding. |
Non-Oncology
Pipeline for Out-licensing or Partnership
|
● |
PCS12852
is a highly specific and potent 5HT4 agonist that has already been evaluated in clinical studies in South Korea for gastric emptying
and gastrointestinal motility in healthy volunteers and volunteers with a history of constipation. In October 2021, the FDA cleared
our IND application to proceed with a Phase 2A trial for the treatment of gastroparesis. We enrolled our first patient on April 5,
2022 and completed enrollment of the trial on September 2, 2022. Results from this Phase 2A trial, which included 25 patients with
moderate to severe gastroparesis, demonstrated improvements in gastric emptying in patients receiving 0.5 mg of PCS12852 as compared
to placebo. The results indicated that for the patients in the PCS12852 group, the mean time for 50% of the gastric contents to empty
(t50) compared to their baseline value (±SD) decreased by -31.90 min (±50.53) (compared to the change seen in the placebo
group of only -9.36 min (±42.43). Significant gastric emptying differences were not observed between the placebo and the 0.1
mg dose. Adverse events associated with the administration of PCS12852 were generally mild to moderate as expected, limited in duration,
and quickly resolved without any sequelae. There were no cardiovascular safety events or serious adverse events reported during the
trial. Additionally, the 0.5 mg of PCS12852 showed a greater improvement than placebo in the gastroparesis symptomology scales (including
both total scores in the scales, as well as sub-scores such as nausea, vomiting and abdominal pain) used in the trial. With the trial
now complete, we have the data necessary to finalize the development plan for the treatment of diabetic gastroparesis patients. We
plan to monetize PCS12852 by looking for licensing and/or partnering opportunities. |
|
● |
PCS499
is an oral tablet of the deuterated analog of one of the major metabolites of pentoxifylline (PTX or Trental®). PCS499 is a drug
that can be used to treat unmet medical need conditions caused by multiple pathophysiological changes. We completed a Phase 2A trial
for PCS499 in patients with ulcerative and non-ulcerative necrobiosis lipoidica (uNL and NL, respectively) in late 2020, and in May
2021, we enrolled the first patient in our Phase 2B trial for the treatment of uNL. Although we initiated several recruitment
programs to increase the enrollment of patients in this trial, we were only able to recruit four patients. We experienced extremely
slow enrollment in the trial given the extreme rarity of the condition (rarer than reported in the literature), the impact of
COVID-19, and the reluctance of patients to be in a clinical trial. We completed the Phase 2B uNL trial for those currently
enrolled, but halted further efforts to enroll new patients in the trial and have terminated the trial. There were no safety
concerns during the conduct of the trial. Although we believe that PCS499 can be effective in treating uNL, we received preliminary
data in late February 2023 that indicated that the placebo response was likely to be much greater than the literature and clinical
experts believe; thus, a much larger sample size would be required in a pivotal trial for an indication where it was extremely
difficult to enroll even four patients. We would like to license and/or find a partner for the future development of PCS499. If this is not possible, we
will return the drug to the licensor. |
Recent
Developments
Through
the date of this Form 10-Q, we had the following significant developments:
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● |
On August 8, 2023, Mr. George Ng was appointed as our Chief Executive Officer and as a Board Director. Mr. Ng is a seasoned life sciences industry executive with significant experience successfully leading small-cap public companies including through product development and fundraising activities. In connection with his employment, Mr. Ng will be paid an annual base salary of $400,000 and will be eligible to receive bonus compensation of up to $100,000 contingent on Mr. Ng. meeting certain performance milestones during 2023 and 2024. In addition, the Compensation Committee awarded 800,000 restricted stock units (“RSUs”) to Mr. Ng. Vesting for 400,000 RSUs occurs ratably over a three-year period. The remaining 400,000 RSUs will vest on the achievement of certain performance metrics, with the first 200,000 performance-based RSUs vesting when gross proceeds of $10,000,000 is raised, and the second 200,000 performance-based RSUs vesting when additional gross proceeds of $10,000,000 is raised. He will also be eligible for other benefits as described in the Employment Agreement.
Given
his oncology and drug development expertise, Dr. David Young will transition to be our President,
Research and Development, concentrating his fulltime effort to drug development of our NGC
drugs. By mutual agreement, Mr. R. Michael Floyd resigned as Chief Operating Officer of
the Company, effective August 31, 2023. |
|
|
|
|
● |
We
raised gross proceeds of $7.0 million (net proceeds of $6.4 million) from the sale of 8,432,192 shares of our common stock through
the following transactions to strengthen our balance sheet and allow us to prepare for our next trial for NGC-Capecitabine: |
|
● |
In
January 2023, we sold 50,000 shares at an average price of $1.08 per share for an aggregate gross proceeds of $54,000 through the
Purchase Agreement we entered into with Lincoln Park Capital in March 2022, under which we have the right, but not the obligation,
to sell to Lincoln Park, and Lincoln Park is obligated to purchase up to $15.0 million of our shares of common stock, subject to
the terms and conditions in the Purchase Agreement. |
|
|
|
|
● |
On
February 3, 2023, we sold 569,648 shares at an average price of $1.22 per share for an aggregate gross proceeds of $693,000 (net
proceeds of $672,000) prior to deducting sales commissions, pursuant to our Sales Agreement with Oppenheimer & Co. Inc., under
which we may issue and sell in a registered “at-the-market” offering shares of our common stock having an aggregate offering
price of up to $30.0 million from time to time. |
|
|
|
|
● |
On
February 14, 2023, we closed a registered direct offering for the sale of 7,812,544 shares of our common stock at a purchase price
of $0.80 per share to accredited investors for gross proceeds of $6.3 million. Net proceeds from the offering were $5.6 million. |
|
● |
Due
to enrollment difficulties that we experienced in our rare disease Phase 2 trial for PCS499 in uNL, we decided to cease further enrollment
in the PCS499 trial in February 2023 and terminated the trial. There were no safety concerns noted during the trial. |
Results
of Operations
Comparison
of the three and six months ended June 30, 2023 and 2022
The
following table summarizes our operations during the periods indicated:
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
Change | | |
2023 | | |
2022 | | |
Change | |
Operating Expenses | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Research and development expenses | |
$ | 1,688,164 | | |
$ | 3,137,292 | | |
$ | (1,449,128 | ) | |
$ | 3,342,509 | | |
$ | 5,181,912 | | |
$ | (1,839,403 | ) |
General and administrative expenses | |
| 1,026,301 | | |
| 2,034,456 | | |
| (1,008,155 | ) | |
| 3,477,490 | | |
| 3,218,550 | | |
| 258,940 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Operating Loss | |
| (2,714,465 | ) | |
| (5,171,748 | ) | |
| | | |
| (6,819,999 | ) | |
| (8,400,462 | ) | |
| | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Other Income (Expense), net | |
| 101,900 | | |
| 7,380 | | |
| 94,519 | | |
| 185,361 | | |
| 8,963 | | |
| 176,398 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Net Operating Loss Before Income Tax Benefit | |
| (2,612,565 | ) | |
| (5,164,368 | ) | |
| 2,551,802 | | |
| (6,634,638 | ) | |
| (8,391,499 | ) | |
| 1,756,861 | |
Income Tax Benefit | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Net Loss | |
$ | (2,612,565 | ) | |
$ | (5,164,368 | ) | |
| | | |
$ | (6,634,638 | ) | |
$ | (8,391,499 | ) | |
| | |
Revenues
We
do not currently have any revenue under contract or any immediate sales prospects.
Research
and development expenses
Our
research and development costs are expensed as incurred. Research and development expenses include: (i) internal research and
development staff related salaries and other payroll costs including stock-based compensation, payroll taxes and employee benefits
and (ii) program and testing related expenses including external consulting and professional fees related to the product testing and
our development activities. In 2022, we also had expenses related to the amortization of the exclusive PCS499 license intangible
asset. Non-refundable advance payments for goods and services to be used in future research and development activities are recorded
as prepaid expenses and expensed when the research and development activities are performed.
Our
research and development expenses decreased during both the three- and six-month periods ended June 30, 2023 when compared to the same
periods in 2022 as shown below.
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Amortization of intangible assets | |
$ | - | | |
$ | 197,124 | | |
$ | - | | |
$ | 394,248 | |
Research and development salaries and benefits | |
| 502,626 | | |
| 1,037,768 | | |
| 1,048,294 | | |
| 1,565,020 | |
Preclinical, clinical trial and other costs | |
| 1,185,538 | | |
| 1,902,400 | | |
| 2,294,215 | | |
| 3,222,644 | |
Total | |
$ | 1,688,164 | | |
$ | 3,137,292 | | |
$ | 3,342,509 | | |
$ | 5,181,912 | |
The
decrease in preclinical, clinical trial and other costs during the three
and six months ended June 30, 2023 when compared to the same period in 2022 was attributable to the completion of our clinical trial for
PCS12852 and the early termination of our clinical trial for PCS499. We also did not have any amortization expense in 2023, as we fully
impaired our intangible asset at December 31, 2022. During the same three- and six-month periods in 2022, we had three active clinical
trials and amortization expense for our intangible asset.
During
the three and six months ended June 30, 2023, when compared to the same period in 2022, we also experienced decreases in stock-based
compensation of $583,000 and $668,000, respectively, as a result of a reduction in stock awards granted. During the same periods, we
experienced increases in payroll and related costs of $48,000 and $151,000, respectively, as a result of increased salary
rates.
Until
we begin our next clinical trial, we anticipate our research and development costs to remain consistent as we close out and receive
final reports related to our clinical trials for PCS499 and PCS12852. We will, however, continue incurring costs in our clinical
trial for NGC-Capecitabine, including the cost of having drug product manufactured and other tasks necessary for the planned Phase 2
clinical trial, as well as costs necessary to submit the Phase 2B protocol for NGC-Gemcitabine.
The
funding necessary to bring a drug candidate to market is subject to numerous uncertainties. Once a drug candidate is identified, the
further development of that drug candidate may be halted or abandoned at any time due to a number of factors. These factors include,
but are not limited to, funding constraints, safety or a change in market demand. For each of our drug candidate programs, we periodically
assess the scientific progress and merits of the programs to determine if continued research and development is economically viable.
Some programs may be terminated due to the lack of scientific progress and lack of prospects for ultimate commercialization.
Our
clinical trial cost accruals are based on estimates of patient enrollment and related costs at clinical investigator sites, as well as
estimates for the services received and efforts expended pursuant to contracts with multiple research institutions and CROs that conduct
and manage clinical trials on our behalf.
We
estimate preclinical and clinical trial expenses based on the services performed, pursuant to contracts with research institutions and
clinical research organizations that conduct and manage preclinical studies and clinical trials on our behalf. In accruing service fees,
we estimate the time period over which services will be performed and the level of patient enrollment and activity expended in each period.
If the actual timing of the performance of services or the level of effort varies from the estimate, we will adjust the accrual accordingly.
Payments made to third parties under these arrangements in advance of the receipt of the related services are recorded as prepaid expenses
and expensed when the services are rendered.
General
and administrative expenses
Our
general and administrative expenses for the three months ended June 30, 2023 decreased by $1.0 million to $1.0 million from $2.0 million
for the three months ended June 30, 2022. This decrease is primarily attributable to a decrease in stock-based compensation of $1.1 million
due to a reduction in stock awards granted. The decrease was primarily offset by increases in payroll and related costs. Reimbursements
from CorLyst totaled $34,000 for rent and other costs during the three months ended June 30, 2023, approximately $1,700 more than reimbursements
for the same period in 2022.
During
the six months ended June 30, 2023, our general and administrative expenses increased by $259,000 to $3.5 million from $3.2
million for the six months ended June 30, 2022. We experienced increases in professional fees of $1.4 million as a result of stock warrants issued to Spartan Capital, as well as in other
expenses including payroll and related costs, insurance, office expenses, and travel of $208,000. These increases were primarily
offset by a decrease in employee stock-based compensation and taxes of $1.4 million due to a reduction in stock awards granted.
Reimbursements from CorLyst totaled $64,000 for rent and other costs during the six months ended June 30, 2023, which was similar to
amounts received during the same period in 2022.
Other
income, net
Other
income represents interest income of $102,000 and $7,400 for the three months ended June 30, 2023 and 2022, respectively, and $185,000
and $9,000 for the six months ended June 30, 2023 and 2022, respectively.
Income
tax benefit
We
did not recognize any income tax benefit for the three or six months ended June 30, 2023 or 2022.
Cash
Flows
The
following table sets forth our sources and uses of cash and cash equivalents for the six months ended June 30, 2023 and 2022:
| |
Six months ended | |
| |
June 30, | |
| |
2023 | | |
2022 | |
Net cash (used in) provided by: | |
| | | |
| | |
Operating activities | |
$ | (4,178,539 | ) | |
$ | (4,133,439 | ) |
Financing activities | |
| 6,352,077 | | |
| (300,000 | ) |
Net increase (decrease) in cash | |
$ | 2,173,538 | | |
$ | (4,433,439 | ) |
Net
cash used in operating activities
We
used net cash in our operating activities of $4,178,539 and $4,133,439 during the six months ended June 30, 2023 and 2022, respectively.
As
we continue our clinical trial for NGC-Capecitabine and evaluate the other NGC drugs in our portfolio, we anticipate our research and
development efforts and ongoing general and administrative costs will continue to generate negative cash flows from operating activities
for the foreseeable future. Until we raise additional funds and begin a new clinical trial, we anticipate clinical trial costs will
decrease when compared to prior periods since we are currently only conducting one clinical trial for NGC-Capecitabine.
Net
cash provided by (used in) financing activities
During
the six months ended June 30, 2023, we raised net proceeds of $6.4 million from the sale of 8,432,192 shares of our common stock. We
used net cash in financing activities during the six months ended June 30, 2022 of $300,000 to purchase 100,000 shares of our common
stock from a licensee.
Going
Concern and Management’s Plans
We
have incurred losses since inception, devoting substantially all of our efforts toward research and development, and have an accumulated
deficit of $70.9 million at June 30, 2023. During the six months ended June 30, 2023, we generated a net loss of $6.6 million and used
$4.2 million in net cash from operating activities from continuing operations. We expect to continue to generate operating losses and
negative cash flow from operations for the foreseeable future.
During
the six months ended June 30, 2023, we raised gross proceeds of $7.0 million (net proceeds of $6.4 million) from the sale of
8,432,192 shares of our common stock, as described in Note 2 to the condensed consolidated financial statements. We plan to use the net proceeds from these financings to prepare for
future clinical trials; on research and development activities; and for working capital and other general corporate purposes.
Our
condensed consolidated financial statements have been prepared using U.S. GAAP and are based on the assumption that we will continue
as a going concern, which contemplates the realization of assets and liquidation of liabilities in the normal course of business. We
face certain risks and uncertainties that are present in many emerging pharmaceutical company regarding product development,
limited working capital, recurring losses and negative cash flow from operations, future profitability, ability to obtain future capital,
protection of patents, technologies and property rights, competition, rapid technological change, navigating the domestic and major foreign
markets’ regulatory and clinical environment, recruiting and retaining key personnel, dependence on third party manufacturing organizations,
third party collaboration and licensing agreements, lack of sales and marketing activities. We currently have no customers or pharmaceutical
products to sell or distribute. These risks and other factors raise substantial doubt about our ability to continue as a going concern.
At
June 30, 2023, we had cash and cash equivalents totaling $8.7 million. Based on our current plans, we believe our current cash balances
will enable us to complete our current clinical trial in NGC-Capecitabine (also known as PCS6422), prepare for future clinical
trials, fund our administrative costs through the second quarter of 2024, and close out the PCS499 and PCS12852 trials. Our ability to
execute our longer-term operating plans, including future clinical trials for our NGC drugs, will depend on our ability to obtain additional
funding from the sale of equity and/or debt securities, a strategic transaction or other funding transactions. We plan to continue to
actively pursue financing alternatives, including out-licensing and/or entering into partnerships on any of our non-core assets, but
there can be no assurance that we will obtain the necessary funding in the future when necessary.
We
had no revenue during the six months ended June 30, 2023 and do not have any revenue under contract or any immediate sales prospects.
Our primary uses of cash are to fund our planned clinical trials, research and development expenditures and other operating expenses.
Cash used to fund operating expenses is impacted by the timing of when we incur and pay these expenses.
We
are hoping to raise additional funds in 2023, but will only do so if terms are acceptable to us. Additional funding may not be
available to us on acceptable terms, or at all. If we are unable to obtain adequate financing when needed, we may have to delay,
reduce the scope of, or suspend our current or planned future clinical trial plans, or research and development programs. We may
seek to raise any necessary additional capital through a combination of public or private equity offerings, debt financings,
collaborations, strategic alliances, licensing arrangements and other marketing and distribution arrangements. To the extent that we
raise additional capital through marketing and distribution arrangements or other collaborations, strategic alliances or licensing
arrangements with third parties, we may have to relinquish valuable rights to our product candidates, future revenue streams,
research programs or product candidates or to grant licenses on terms that may not be favorable to us. If we raise additional
capital through public or private equity offerings, the ownership interest of our existing stockholders will be diluted, and the
terms of these securities may include liquidation or other preferences that adversely affect our stockholders’ rights. If we
raise additional capital through debt financing, we may be subject to covenants limiting or restricting our ability to take specific
actions, such as incurring additional debt, making capital expenditures or declaring dividends.
Our
future capital requirements will depend on many factors, including:
|
● |
the
cost of our current clinical trials and the cost of third-party manufacturing; |
|
● |
the
initiation, progress, timing, costs and results of drug manufacturing, pre-clinical studies, and clinical trials of PCS3117 and PCS11T,
as well as any other future product candidates; |
|
● |
the
number and characteristics of product candidates that we pursue; |
|
● |
the
outcome, timing, and costs of seeking regulatory approvals; |
|
● |
the
costs associated with hiring additional personnel and consultants for our pre-clinical and clinical activities; |
|
● |
the
emergence of competing therapies and other adverse market developments; |
|
● |
the
costs involved in preparing, filing, prosecuting, maintaining, expanding, defending, and enforcing patent claims, including litigation
costs and the outcome of such litigation; |
|
● |
the
extent to which we in-license or acquire other products and technologies; and |
|
● |
the
costs of operating as a public company. |
Until
such time as we can generate substantial product revenues to support our capital requirements, if ever, we expect to finance our cash
needs through a combination of public or private equity offerings, debt financings, collaborations and licensing arrangements or other
capital sources. We currently have an effective S-3 shelf registration statement on file with the SEC, which provides us flexibility
and optionality to raise capital, including pursuant to a Purchase Agreement with Lincoln Park Capital or a future at-the-market offering,
but there can be no assurance that capital will continue to be available to us on acceptable terms, won’t be limited, or be available
at all. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the ownership interest
of our stockholders will or could be diluted, and the terms of these securities may include liquidation or other preferences that adversely
affect the rights of our common stockholders.
Uncertainty
concerning our ability to continue as a going concern may hinder our ability to obtain future financing. Continued operations and our
ability to continue as a going concern are dependent on our ability to obtain additional funding in the future and thereafter, and no
assurances can be given that such funding will be available at all, in a sufficient amount, or on reasonable terms. Without additional
funds from debt or equity financing, sales of assets, sales or out-licenses of intellectual property or technologies, or other transactions
providing funds, we will rapidly exhaust our resources and be unable to continue operations. Absent additional funding, we believe that
our cash and cash equivalents will not be sufficient to fund our operations for a period of one year or more after the date that these
condensed consolidated financial statements are available to be issued based on the timing and amount of our projected net loss from
continuing operations and cash to be used in operating activities during that period of time.
As
a result, substantial doubt exists about our ability to continue as a going concern within one year after the date that these condensed
consolidated financial statements are available to be issued. The accompanying condensed consolidated financial statements do not include
any adjustments to reflect the possible future effects on the recoverability and classification of recorded assets, or the amounts and
classification of liabilities that might be different should we be unable to continue as a going concern based on the outcome of these
uncertainties described above.
Our
estimate of future cash needs is based on assumptions that may prove to be wrong, and we could utilize our available cash sooner than
we currently expect. Our ultimate success depends on the outcome of our planned clinical trials and our research and development activities,
as disclosed above. We expect to incur additional losses in the future, and we will need to raise additional capital to fully implement
our business plan if the costs of our clinical trials are greater than we expect or they take longer than anticipated. We also expect
to incur increased general and administrative expenses in the future. In addition, there may be costs we incur as we develop these drug
products that we do not currently anticipate, requiring us to need additional capital sooner than currently expected.
Contractual
Obligations and Commitments
There
have been no significant changes to the contractual obligations reported in our Annual Report on Form 10-K for the fiscal year ended
December 31, 2022.
Off
Balance Sheet Arrangements
At
June 30, 2023, we did not have any off-balance sheet arrangements.
Critical
Accounting Policies and Use of Estimates
Our
discussion and analysis of our financial condition and results of operations are based upon our Unaudited Condensed Consolidated Financial
Statements, which have been prepared in accordance with U.S. GAAP. The preparation of these financial statements requires us to make
estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses and related disclosure of contingent
assets and liabilities.
We
believe that the estimates, assumptions, and judgments involved in the accounting policies described in the “Management’s
Discussion and Analysis of Financial Condition and Results of Operations” section of our most recent Annual Report on Form 10-K
have the greatest potential impact on our financial statements, so we consider these to be our critical accounting policies. Actual results
could differ from the estimates we use in applying our critical accounting policies. We are not currently aware of any reasonably likely
events or circumstances that would result in materially different amounts being reported.
There
have been no changes in our critical accounting policies since our most recent Annual Report on Form 10-K.
Recently
Issued Accounting Pronouncements
We
have evaluated recently issued accounting pronouncements and determined that there is no material impact on our condensed
consolidated financial position or results of operations.
Item
3. Quantitative and Qualitative Disclosures About Market Risk
Item
3 is not applicable to us as a smaller reporting company and has been omitted.
Item
4. Controls and Procedures
At
June 30, 2023, management, with the participation of the then Chief Executive Officer
and Chief Financial Officer, conducted an evaluation of the effectiveness of the design and operation of our disclosure controls and
procedures, as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act. Based on the evaluation of its disclosure controls
and procedures, the then Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures
were effective at June 30, 2023 to provide reasonable assurance that information
required to be disclosed in our reports under the Exchange Act is (i) recorded, processed, summarized and reported within the time
periods specified in the SEC’s rules and forms and (ii) accumulated and communicated to our management, as appropriate, to
allow timely decisions regarding required disclosure. In designing and evaluating our disclosure controls and procedures, management
recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of
achieving their objectives, and management necessarily applies its judgment in evaluating the benefits of possible controls and
procedures relative to their costs.
Changes
in Internal Control over Financial Reporting
There
were no changes in our internal control over financial reporting during the quarter ended June 30, 2023 that have materially affected
or are reasonably likely to materially affect our internal control over financial reporting.
PART
II. OTHER INFORMATION
Item
1. Legal Proceedings
We
are currently not a party to any material legal proceedings.
Item
1A. Risk Factors
In
addition to the information set forth in this report, you should carefully consider the risk factors discussed in Item 1A. of Part I
of our Annual Report on Form 10-K for the year ended December 31, 2022 (“2022 Annual Report”)
Nasdaq
may delist our securities from trading on its exchange which could limit investors’ ability to make transactions in our securities
and subject us to additional trading restrictions.
Our
securities are currently listed on the Nasdaq. If Nasdaq delists our securities from trading on its exchange, we could face significant
material adverse consequences, including:
|
● |
a limited availability of market quotations for our securities; |
|
● |
reduced liquidity with respect to our securities; |
|
● |
a determination that shares of our common stock are “penny stock”
which will require brokers trading in our shares to adhere to more stringent rules, possibly resulting in a reduced level of trading activity
in the secondary trading market for our shares; |
|
● |
a limited amount of news and analyst coverage; and |
|
● |
a decreased ability to issue additional securities or obtain additional
financing in the future. |
On
March 22, 2023, we received a deficiency letter from the Nasdaq Listing Qualifications Department (the “Staff”) notifying
us that, for the last 30 consecutive business days, the closing bid price for the Company’s common stock has been below the minimum
$1.00 per share required for continued listing on The Nasdaq Capital Market pursuant to Nasdaq Listing Rule 5550(a)(2) (“Rule 5550(a)(2)”).
As a result, the Company is not in compliance with the $1.00 minimum bid price requirement for the continued listing on the Nasdaq Capital
Market. In accordance with Nasdaq Listing Rule 5810(c)(3)(A), the Company had been given 180 calendar days, or until September 18, 2023,
to regain compliance with Rule 5550(a)(2).
The
National Securities Markets Improvement Act of 1996, which is a federal statute, prevents or preempts the states from regulating the
sale of certain securities, which are referred to as “covered securities.” Because our common stock is listed on Nasdaq,
our securities are covered securities. If we are no longer listed on Nasdaq, our securities would not be covered securities and we would
be subject to regulation in each state in which our securities are offered.
Item
2. Unregistered Sales of Equity Securities and Use of Proceeds
(a)
Recent Sale of Unregistered Securities
None.
(b)
Use of Proceeds from Public Offering of Common Stock
None.
(c)
Issuer Purchases of Equity Securities
None.
Item
3. Defaults Upon Senior Securities
None.
Item
4. Mine Safety Disclosures
Not
applicable.
Item
5. Other Information
During the three months ended June 30, 2023, there were no modifications,
adoptions or terminations by any directors or
officers to any contract, instruction or written plan for the purchase or sale of securities of the Company that is intended to satisfy
the affirmative defense conditions of Rule 10b5-1(c) or non-Rule 10b5-1 trading agreements.
Item
6. Exhibits
*
Filed herewith.
++
This certification is being furnished solely to accompany this Quarterly Report pursuant to 18 U.S.C. Section 1350 and are not being
filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and are not to be incorporated by reference into
any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing
herewith.
SIGNATURES
Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned thereunto duly authorized.
|
PROCESSA
PHARMACEUTICALS, INC. |
|
|
|
|
By: |
/s/
Dr. David Young |
|
|
Dr. David Young |
|
|
President, Research and Development
|
|
|
(Acting Principal Executive Officer) |
|
|
|
|
Dated:
|
August
10, 2023 |
|
|
|
|
By: |
/s/
James Stanker |
|
|
James
Stanker |
|
|
Chief
Financial Officer |
|
|
(Principal
Financial and Accounting Officer) |
|
|
|
|
Dated:
|
August
10, 2023 |
Exhibit 31.1
CERTIFICATION
I, Dr. David Young, President, Research and
Development (Acting Principal Executive Officer) of PROCESSA PHARMACEUTICALS, INC. certify that:
1. I have reviewed this quarterly report on Form 10-Q
of PROCESSA PHARMACEUTICALS, INC. for the six months ended June 30, 2023;
2. Based on my knowledge, this report does not contain
any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances
under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements,
and other financial information included in this report, fairly present in all material respects the financial condition, results of operations
and cash flows of the registrant at, and for, the periods presented in this report;
4. I am responsible for establishing and maintaining
disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting
(as defined in Exchange Act Rules13a-15(f) and 15d-15 (f)) for the registrant and have:
a. Designed such disclosure controls
and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information
relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly
during the period in which this report is being prepared;
b. Designed such internal control
over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance
with generally accepted accounting principles;
c. Evaluated the effectiveness
of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the
disclosure controls and procedures, at the end of the period covered by this report based on such evaluation; and
d. Disclosed in this report any
change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal
quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably
likely to materially affect, the registrant’s internal control over financial reporting.
5. I have disclosed, based on our most recent evaluation
of internal control over financial reporting, to the registrant’s auditors and the audit committee of registrant’s board of
directors (or persons performing equivalent functions):
a. All significant deficiencies
and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely
affect the registrant’s ability to record, process, summarize and report financial information; and
b. Any fraud, whether or not material,
that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
|
By: |
/s/ Dr. David Young |
|
|
Dr. David Young |
|
|
President, Research and Development |
|
|
(Acting Principal Executive Officer) |
|
|
|
|
Date: |
August 10, 2023 |
Exhibit 31.2
CERTIFICATION
I, James Stanker, Chief Financial Officer of PROCESSA
PHARMACEUTICALS, INC. certify that:
1. I have reviewed this quarterly report on Form 10-Q
of PROCESSA PHARMACEUTICALS, INC. for the six months ended June 30, 2023;
2. Based on my knowledge, this report does not contain
any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances
under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements,
and other financial information included in this report, fairly present in all material respects the financial condition, results of operations
and cash flows of the registrant at, and for, the periods presented in this report;
4. I am responsible for establishing and maintaining
disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting
(as defined in Exchange Act Rules13a-15(f) and 15d-15 (f)) for the registrant and have:
a. Designed such disclosure controls
and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information
relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly
during the period in which this report is being prepared;
b. Designed such internal control
over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance
with generally accepted accounting principles;
c. Evaluated the effectiveness
of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the
disclosure controls and procedures, at the end of the period covered by this report based on such evaluation; and
d. Disclosed in this report any
change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal
quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably
likely to materially affect, the registrant’s internal control over financial reporting.
5. I have disclosed, based on our most recent evaluation
of internal control over financial reporting, to the registrant’s auditors and the audit committee of registrant’s board of
directors (or persons performing equivalent functions):
a. All significant deficiencies
and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely
affect the registrant’s ability to record, process, summarize and report financial information; and
b. Any fraud, whether or not material,
that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
|
By: |
/s/ James
Stanker |
|
|
James Stanker |
|
|
Chief Financial Officer
(Principal Financial and Accounting Officer) |
|
|
|
|
Date: |
August 10, 2023 |
Exhibit 32.1
Written Statement of the Chief Executive Officer
and Chief Financial Officer Pursuant to 18 U.S.C. §1350
Solely for the purposes of complying with 18 U.S.C.
§1350, I, the undersigned President, Research and Development (Acting Principal Executive Officer) of Processa Pharmaceuticals, Inc. (the “Company”), hereby certify,
to the best of my knowledge, that the quarterly report on Form 10-Q of the Company for the quarter ended June 30, 2023 (the “Report”)
fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 and that the information
contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
This certification is being furnished solely to accompany
this Report pursuant to 18 U.S.C. 1350 and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934 and is
not to be incorporated by reference into any filing of the registrant, whether made before or after the date hereof, regardless of any
general incorporation language in such filing.
|
By: |
/s/ Dr. David Young |
|
|
Dr. David Young |
|
|
President, Research and Development |
|
|
(Acting Principal Executive Officer)
|
|
|
|
|
Date: |
August 10, 2023 |
Solely for the purposes of complying with 18 U.S.C.
§1350, I, the undersigned Chief Financial Officer of Processa Pharmaceuticals, Inc. (the “Company”), hereby certify,
to the best of my knowledge, that the quarterly report on Form 10-Q of the Company for the quarter ended June 30, 2023 (the “Report”)
fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 and that the information
contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
This certification is being furnished solely to accompany
this Report pursuant to 18 U.S.C. 1350 and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934 and is
not to be incorporated by reference into any filing of the registrant, whether made before or after the date hereof, regardless of any
general incorporation language in such filing.
|
By: |
/s/ James Stanker |
|
|
James Stanker |
|
|
Chief Financial Officer
(Principal Financial and Accounting Officer) |
|
|
|
|
Date: |
August 10, 2023 |
v3.23.2
Cover - shares
|
6 Months Ended |
|
Jun. 30, 2023 |
Aug. 04, 2023 |
Cover [Abstract] |
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10-Q
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Document Period End Date |
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|
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Document Fiscal Period Focus |
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|
|
Document Fiscal Year Focus |
2023
|
|
Current Fiscal Year End Date |
--12-31
|
|
Entity File Number |
001-39531
|
|
Entity Registrant Name |
Processa
Pharmaceuticals, Inc.
|
|
Entity Central Index Key |
0001533743
|
|
Entity Tax Identification Number |
45-1539785
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|
Entity Incorporation, State or Country Code |
DE
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Entity Address, Address Line One |
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Coca Cola Drive
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Entity Address, Address Line Two |
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Entity Address, City or Town |
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Entity Address, State or Province |
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|
Entity Address, Postal Zip Code |
21076
|
|
City Area Code |
(443)
|
|
Local Phone Number |
776-3133
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Title of 12(b) Security |
Common
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Trading Symbol |
PCSA
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Security Exchange Name |
NASDAQ
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v3.23.2
Condensed Consolidated Balance Sheets (Unaudited) - USD ($)
|
Jun. 30, 2023 |
Dec. 31, 2022 |
Current Assets |
|
|
Cash and cash equivalents |
$ 8,677,133
|
$ 6,503,595
|
Prepaid expenses and other |
1,220,150
|
1,883,134
|
Total Current Assets |
9,897,283
|
8,386,729
|
Property and Equipment, net |
|
|
Other Assets |
|
|
Operating lease right-of-use assets, net |
187,605
|
227,587
|
Security deposit |
5,535
|
5,535
|
Total Other Assets |
193,140
|
233,122
|
Total Assets |
10,090,423
|
8,619,851
|
Current Liabilities |
|
|
Current maturities of operating lease liability |
81,890
|
78,896
|
Accounts payable |
239,022
|
327,548
|
Due to licensor |
189,000
|
189,000
|
Due to related parties |
|
$ 51
|
Other Liability, Current, Related Party, Type [Extensible Enumeration] |
|
Related Party [Member]
|
Accrued expenses |
311,502
|
$ 403,061
|
Total Current Liabilities |
821,414
|
998,556
|
Non-current Liabilities |
|
|
Non-current operating lease liability |
109,327
|
150,554
|
Total Liabilities |
930,741
|
1,149,110
|
Commitments and Contingencies |
|
|
Stockholders’ Equity |
|
|
Common stock, par value $0.0001, 100,000,000 shares authorized: 24,631,474 issued and 24,531,474 outstanding at June 30, 2023, and 16,135,400 issued and 16,035,400 outstanding at December 31, 2022 |
2,463
|
1,614
|
Additional paid-in capital |
80,339,418
|
72,016,688
|
Treasury stock at cost — 100,000 shares at June 30, 2023 and December 31, 2022 |
(300,000)
|
(300,000)
|
Accumulated deficit |
(70,882,199)
|
(64,247,561)
|
Total Stockholders’ Equity |
9,159,682
|
7,470,741
|
Total Liabilities and Stockholders’ Equity |
$ 10,090,423
|
$ 8,619,851
|
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v3.23.2
Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares
|
Jun. 30, 2023 |
Dec. 31, 2022 |
Statement of Financial Position [Abstract] |
|
|
Common stock, par value |
$ 0.0001
|
$ 0.0001
|
Common stock, shares authorized |
100,000,000
|
100,000,000
|
Common stock, shares issued |
24,631,474
|
16,135,400
|
Common stock, shares outstanding |
24,531,474
|
16,035,400
|
Treasury stock shares |
100,000
|
100,000
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.23.2
Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Operating Expenses |
|
|
|
|
Research and development expenses |
$ 1,688,164
|
$ 3,137,292
|
$ 3,342,509
|
$ 5,181,912
|
General and administrative expenses |
1,026,301
|
2,034,456
|
3,477,490
|
3,218,550
|
Operating Loss |
(2,714,465)
|
(5,171,748)
|
(6,819,999)
|
(8,400,462)
|
Other Income (Expense), net |
101,900
|
7,380
|
185,361
|
8,963
|
Net Operating Loss Before Income Tax Benefit |
(2,612,565)
|
(5,164,368)
|
(6,634,638)
|
(8,391,499)
|
Income Tax Benefit |
|
|
|
|
Net Loss |
$ (2,612,565)
|
$ (5,164,368)
|
$ (6,634,638)
|
$ (8,391,499)
|
Net Loss per Common Share - Basic |
$ (0.10)
|
$ (0.32)
|
$ (0.27)
|
$ (0.53)
|
Net Loss per Common Share - Diluted |
$ (0.10)
|
$ (0.32)
|
$ (0.27)
|
$ (0.53)
|
Weighted Average Common Shares Used to Compute Net Loss Applicable to Common Shares - Basic |
26,935,463
|
15,940,510
|
24,864,630
|
15,886,116
|
Weighted Average Common Shares Used to Compute Net Loss Applicable to Common Shares - Diluted |
26,935,463
|
15,940,510
|
24,864,630
|
15,886,116
|
X |
- DefinitionThe amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.
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v3.23.2
Condensed Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($)
|
Common Stock [Member] |
Additional Paid-in Capital [Member] |
Treasury Stock, Common [Member] |
Retained Earnings [Member] |
Total |
Beginning balance, value at Dec. 31, 2021 |
$ 1,571
|
$ 62,306,861
|
|
$ (36,823,332)
|
$ 25,485,100
|
Beginning balance, shares at Dec. 31, 2021 |
15,710,246
|
|
|
|
|
Stock-based compensation |
$ 10
|
828,887
|
|
|
828,897
|
Stock-based compensation, shares |
103,670
|
|
|
|
|
Acquisition of treasury stock |
|
|
$ (300,000)
|
|
(300,000)
|
Acquisition of treasury stock, shares |
|
|
(100,000)
|
|
|
Shares issued in connection with the Purchase Agreement with Lincoln Park |
$ 12
|
449,988
|
|
|
450,000
|
Shares issued in connection with the Purchase Agreement with Lincoln Park, shares |
123,609
|
|
|
|
|
Net loss |
|
|
|
(3,227,131)
|
(3,227,131)
|
Ending balance, value at Mar. 31, 2022 |
$ 1,593
|
63,585,736
|
$ (300,000)
|
(40,050,463)
|
23,236,866
|
Ending balance, shares at Mar. 31, 2022 |
15,937,525
|
|
(100,000)
|
|
|
Beginning balance, value at Dec. 31, 2021 |
$ 1,571
|
62,306,861
|
|
(36,823,332)
|
25,485,100
|
Beginning balance, shares at Dec. 31, 2021 |
15,710,246
|
|
|
|
|
Net loss |
|
|
|
|
(8,391,499)
|
Ending balance, value at Jun. 30, 2022 |
$ 1,592
|
65,595,106
|
$ (300,000)
|
(45,214,831)
|
20,081,867
|
Ending balance, shares at Jun. 30, 2022 |
15,919,317
|
|
(100,000)
|
|
|
Beginning balance, value at Mar. 31, 2022 |
$ 1,593
|
63,585,736
|
$ (300,000)
|
(40,050,463)
|
23,236,866
|
Beginning balance, shares at Mar. 31, 2022 |
15,937,525
|
|
(100,000)
|
|
|
Stock-based compensation |
$ (1)
|
2,009,370
|
|
|
2,009,369
|
Stock-based compensation, shares |
(18,208)
|
|
|
|
|
Net loss |
|
|
|
(5,164,368)
|
(5,164,368)
|
Ending balance, value at Jun. 30, 2022 |
$ 1,592
|
65,595,106
|
$ (300,000)
|
(45,214,831)
|
20,081,867
|
Ending balance, shares at Jun. 30, 2022 |
15,919,317
|
|
(100,000)
|
|
|
Beginning balance, value at Dec. 31, 2022 |
$ 1,614
|
72,016,688
|
$ (300,000)
|
(64,247,561)
|
7,470,741
|
Beginning balance, shares at Dec. 31, 2022 |
16,135,400
|
|
(100,000)
|
|
|
Stock-based compensation |
$ 6
|
341,498
|
|
|
341,504
|
Stock-based compensation, shares |
63,882
|
|
|
|
|
Net loss |
|
|
|
(4,022,073)
|
(4,022,073)
|
Shares issued in connection with capital raises, net of transaction costs |
$ 843
|
6,351,234
|
|
|
6,352,077
|
Shares issued in connection with capital raises, net of transaction costs, shares |
8,432,192
|
|
|
|
|
Ending balance, value at Mar. 31, 2023 |
$ 2,463
|
78,709,420
|
$ (300,000)
|
(68,269,634)
|
10,142,249
|
Ending balance, shares at Mar. 31, 2023 |
24,631,474
|
|
(100,000)
|
|
|
Beginning balance, value at Dec. 31, 2022 |
$ 1,614
|
72,016,688
|
$ (300,000)
|
(64,247,561)
|
7,470,741
|
Beginning balance, shares at Dec. 31, 2022 |
16,135,400
|
|
(100,000)
|
|
|
Net loss |
|
|
|
|
(6,634,638)
|
Shares issued in connection with capital raises, net of transaction costs, shares |
8,432,192
|
|
|
|
|
Ending balance, value at Jun. 30, 2023 |
$ 2,463
|
80,339,418
|
$ (300,000)
|
(70,882,199)
|
9,159,682
|
Ending balance, shares at Jun. 30, 2023 |
24,631,474
|
|
(100,000)
|
|
|
Beginning balance, value at Mar. 31, 2023 |
$ 2,463
|
78,709,420
|
$ (300,000)
|
(68,269,634)
|
10,142,249
|
Beginning balance, shares at Mar. 31, 2023 |
24,631,474
|
|
(100,000)
|
|
|
Stock-based compensation |
|
319,123
|
|
|
319,123
|
Net loss |
|
|
|
(2,612,565)
|
(2,612,565)
|
Warrants issued in connection with consulting agreement |
|
1,310,875
|
|
|
1,310,875
|
Ending balance, value at Jun. 30, 2023 |
$ 2,463
|
$ 80,339,418
|
$ (300,000)
|
$ (70,882,199)
|
$ 9,159,682
|
Ending balance, shares at Jun. 30, 2023 |
24,631,474
|
|
(100,000)
|
|
|
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v3.23.2
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
|
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Cash Flows From Operating Activities |
|
|
Net loss |
$ (6,634,638)
|
$ (8,391,499)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Non-cash lease expense for right-of-use assets |
39,982
|
45,291
|
Non-cash milestone expense in connection with license agreement |
|
189,000
|
Amortization of issuance costs |
|
40,613
|
Amortization of intangible asset |
|
394,248
|
Stock-based compensation |
660,627
|
2,838,266
|
Warrants issued to purchase 3,160,130 shares of common stock in connection with a consulting agreement |
1,310,875
|
|
Net changes in operating assets and liabilities: |
|
|
Prepaid expenses and other |
662,984
|
272,050
|
Operating lease liability |
(38,233)
|
(47,256)
|
Accounts payable |
(88,526)
|
429,199
|
Due (from) to related parties |
(51)
|
(1,772)
|
Other receivables |
|
70,274
|
Accrued expenses |
(91,559)
|
28,147
|
Net cash used in operating activities |
(4,178,539)
|
(4,133,439)
|
Cash Flows From Financing Activities |
|
|
Net proceeds from common stock issued |
6,352,077
|
|
Acquisition of treasury stock |
|
(300,000)
|
Net cash provided by (used in) financing activities |
6,352,077
|
(300,000)
|
Net Increase (Decrease) in Cash |
2,173,538
|
(4,433,439)
|
Cash and Cash Equivalents – Beginning of Period |
6,503,595
|
16,497,581
|
Cash and Cash Equivalents – End of Period |
8,677,133
|
12,064,142
|
Non-Cash Financing Activities |
|
|
Issuance of 123,609 shares of common stock in connection with the Purchase Agreement with Lincoln Park |
|
$ 450,000
|
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v3.23.2
Organization and Summary of Significant Accounting Policies
|
6 Months Ended |
Jun. 30, 2023 |
Accounting Policies [Abstract] |
|
Organization and Summary of Significant Accounting Policies |
Note
1 – Organization and Summary of Significant Accounting Policies
Organization
We
are a clinical-stage biopharmaceutical company focused on incorporating our Regulatory Science Approach into the development of our Next
Generation Chemotherapy (NGC) drugs to improve the safety and efficacy of cancer treatment. Our NGC drugs are modifications of existing
FDA-approved oncology drugs resulting in an alteration of the metabolism and/or distribution while maintaining the well-known and established
existing mechanisms of killing the cancer cells. By modifying the NGC drugs in this manner, we believe our three NGC treatments will
provide improved safety-efficacy profiles when compared to their currently marketed counterparts.
Basis
of Presentation
The
accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally
accepted in the United States of America (“U.S. GAAP”) for interim financial information and with the instructions of the
Securities and Exchange Commission (“SEC”) on Form 10-Q and Article 8 of Regulation S-X.
Accordingly,
they do not include all the information and disclosures required by U.S. GAAP for complete financial statements. All material intercompany
accounts and transactions have been eliminated in consolidation. In the opinion of management, the accompanying unaudited condensed consolidated
financial statements include all adjustments necessary, which are of a normal and recurring nature, for the fair presentation of our
financial position and of the results of operations and cash flows for the periods presented. These condensed consolidated financial
statements should be read in conjunction with the audited financial statements and notes thereto included in our Annual Report on Form
10-K for the year ended December 31, 2022, as filed with the SEC. The results of operations for the interim periods shown in this report
are not necessarily indicative of the results that may be expected for any other interim period or for the full year.
Going
Concern and Management’s Plans
We
have incurred losses since inception, devoting substantially all of our efforts toward research and development, and have an accumulated
deficit of $70.9 million at June 30, 2023. During the six months ended June 30, 2023, we generated a net loss of $6.6 million and used
$4.2 million in net cash from operating activities from continuing operations. We expect to continue to generate operating losses and
negative cash flow from operations for the foreseeable future.
During
the six months ended June 30, 2023, we raised gross proceeds of $7.0 million (net proceeds of $6.4 million) from the sale of 8,432,192
shares of our common stock, as described in Note 2. We plan to use the net proceeds from these financings to prepare for future clinical
trials; and on research and development expenses, working capital and other general corporate purposes.
Our
condensed consolidated financial statements have been prepared using U.S. GAAP and are based on the assumption that we will continue
as a going concern, which contemplates the realization of assets and liquidation of liabilities in the normal course of business. We
face certain risks and uncertainties that are present in many emerging pharmaceutical companies regarding product development,
limited working capital, recurring losses and negative cash flow from operations, future profitability, ability to obtain future capital,
protection of patents, technologies and property rights, competition, rapid technological change, navigating the domestic and major foreign
markets’ regulatory and clinical environment, recruiting and retaining key personnel, dependence on third party manufacturing organizations,
third party collaboration and licensing agreements, lack of sales and marketing activities. We currently have no customers or pharmaceutical
products to sell or distribute. These risks and other factors raise substantial doubt about our ability to continue as a going concern.
At
June 30, 2023, we had cash and cash equivalents totaling $8.7
million. Based on our current plans, we believe our current cash balances will enable us to complete our current clinical trial in
NGC-Capecitabine (also known as PCS6422), prepare for future clinical trials, fund our administrative costs through the second
quarter of 2024, and close out the PCS499 and PCS12852 trials. Our ability to execute our longer-term operating plans, including
future clinical trials for our NGC drugs, will depend on our ability to obtain additional funding from the
sale of equity and/or debt securities, a strategic transaction or other funding transactions. We plan to continue to actively pursue
financing alternatives, including out-licensing and/or entering into partnerships on any of our non-core assets, but there can be no
assurance that we will obtain the necessary funding in the future when necessary.
We
had no revenue during the six months ended June 30, 2023 and do not have any revenue under contract or any immediate sales prospects.
Our primary uses of cash are to fund our planned clinical trials, research and development expenditures and other operating expenses.
Cash used to fund operating expenses is impacted by the timing of when we incur and pay these expenses.
We
are hoping to raise additional funds in 2023, but will only do so if terms are acceptable to us. Additional funding may not be
available to us on acceptable terms, or at all. If we are unable to obtain adequate financing when needed, we may have to delay,
reduce the scope of, or suspend our current or planned future clinical trial plans, or research and development programs. We may
seek to raise any necessary additional capital through a combination of public or private equity offerings, debt financings,
collaborations, strategic alliances, licensing arrangements and other marketing and distribution arrangements. To the extent that we
raise additional capital through marketing and distribution arrangements or other collaborations, strategic alliances or licensing
arrangements with third parties, we may have to relinquish valuable rights to our product candidates, future revenue streams,
research programs or product candidates or to grant licenses on terms that may not be favorable to us. If we raise additional
capital through public or private equity offerings, the ownership interest of our existing stockholders will be diluted, and the
terms of these securities may include liquidation or other preferences that adversely affect our stockholders’ rights. If we
raise additional capital through debt financing, we may be subject to covenants limiting or restricting our ability to take specific
actions, such as incurring additional debt, making capital expenditures or declaring dividends.
Uncertainty
concerning our ability to continue as a going concern may hinder our ability to obtain future financing. Continued operations and our
ability to continue as a going concern are dependent on our ability to obtain additional funding in the future and thereafter, and no
assurances can be given that such funding will be available at all, in a sufficient amount, or on reasonable terms. Without additional
funds from debt or equity financing, sales of assets, sales or out-licenses of intellectual property or technologies, or other transactions
providing funds, we will rapidly exhaust our resources and be unable to continue operations. Absent additional funding, we believe that
our cash and cash equivalents will not be sufficient to fund our operations for a period of one year or more after the date that these
condensed consolidated financial statements are available to be issued based on the timing and amount of our projected net loss from
continuing operations and cash to be used in operating activities during that period of time.
As
a result, substantial doubt exists about our ability to continue as a going concern within one year after the date that these condensed
consolidated financial statements are available to be issued. The accompanying condensed consolidated financial statements do not include
any adjustments to reflect the possible future effects on the recoverability and classification of recorded assets, or the amounts and
classification of liabilities that might be different should we be unable to continue as a going concern based on the outcome of these
uncertainties described above.
Use
of Estimates
In
preparing our condensed consolidated financial statements and related disclosures in conformity with U.S. GAAP and pursuant to the rules
and regulations of the SEC, we make estimates and judgments that affect the amounts reported in the condensed consolidated financial
statements and accompanying notes. Estimates are used for, but not limited to preclinical and clinical trial expenses, stock-based compensation,
intangible assets, future milestone payments and income taxes. These estimates and assumptions are continuously evaluated and are based
on management’s experience and knowledge of the relevant facts and circumstances. While we believe the estimates to be reasonable,
actual results could differ materially from those estimates and could impact future results of operations and cash flows.
Income
Taxes
We
account for income taxes in accordance with ASC Topic 740, Income Taxes. Deferred income taxes are recorded for the expected tax
consequences of temporary differences between the basis of assets and liabilities for financial reporting purposes and amounts recognized
for income tax purposes. At June 30, 2023 and December 31, 2022, we recorded a valuation allowance equal to the full recorded amount
of our net deferred tax assets since it is more-likely-than-not that such benefits will not be realized. The valuation allowance is reviewed
quarterly and is maintained until sufficient positive evidence exists to support its reversal.
Under
ACS 740-270 Income Taxes – Interim Reporting, we are required to project our annual federal and state effective income tax
rate and apply it to the year-to-date ordinary operating tax basis loss before income taxes. Based on the projection, no current income
tax benefit or expense is expected for 2023 and the foreseeable future since we expect to generate taxable net operating losses.
Concentration
of Credit Risk
Financial
instruments that potentially subject us to significant concentration of credit risk consist primarily of our cash and cash equivalents.
We utilize only well-established banks and financial institutions with high credit ratings. Balances on deposit are insured by the Federal
Deposit Insurance Corporation (FDIC) up to specified limits. Total cash held by our banks at June 30, 2023, exceeded FDIC limits.
Recent
Accounting Pronouncements
From
time to time, the Financial Accounting Standards Board (“FASB”) or other standard setting bodies issue new accounting pronouncements.
Updates to the FASB Accounting Standards Codification are communicated through issuance of an Accounting Standards Update (“ASU”).
We have implemented all new accounting pronouncements that are in effect and that may impact our condensed consolidated financial statements.
We have evaluated recently issued accounting pronouncements and determined that there is no material impact on our consolidated financial
position or results of operations.
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v3.23.2
Stockholders’ Equity
|
6 Months Ended |
Jun. 30, 2023 |
Equity [Abstract] |
|
Stockholders’ Equity |
Note
2 – Stockholders’ Equity
Preferred
Stock
There
were no issued or outstanding shares of preferred stock at either June 30, 2023 or December 31, 2022.
Common
Stock
Increase in Our Authorized Number of Shares
Subsequent to receiving shareholder approval on June 27, 2023, we amended
our Certificate of Incorporation to increase the number of authorized shares of our common stock from 50,000,000 to 100,000,000. We believe
100,000,000 authorized shares of common stock better aligns our capital structure with our future needs and have shown this retroactively
in the condensed consolidated financial statements.
During
the six months ended June 30, 2023, we issued 8,432,192
shares of our common stock through several fundraising
efforts described below:
ATM
Offering
On
August 20, 2021, we entered into the Sales Agreement with Oppenheimer & Co. Inc. (the “Sales Agent”) under which we may
issue and sell up to $30.0 million from time to time under the ATM Offering. We expect to use net proceeds from the ATM Offering over
time as a source for working capital and general corporate purposes. During the six months ended June 30, 2023, we sold 569,648 shares
at an average price of $1.22 per share for aggregate gross proceeds of $693,000 (net proceeds of $672,000) prior to deducting sales commissions.
On February 5, 2023, in connection with our Registered Direct Offering, we suspended the Sales Agreement with the Sales Agent, but we
expect to reinstate it in the future.
Lincoln
Park Capital Fund, LLC Purchase Agreement
On
March 23, 2022, we entered into the Purchase Agreement with Lincoln Park, pursuant to which Lincoln Park has committed to purchase up
to $15.0 million of shares (the “Purchase Shares”) of our common stock, subject to the terms and conditions in the Purchase
Agreement with Lincoln Park, including that the closing sale price of the common stock on the purchase date is not below a threshold
price of $1.00. Any proceeds that we receive under the Purchase Agreement are expected to be used for working capital and general corporate
purposes. During the six months ended June 30, 2023, we sold 50,000 shares at an average price of $1.08 per share for aggregate gross
proceeds of $54,000 under the Purchase Agreement with Lincoln Park.
Registered
Direct Offering
On
February 14, 2023, we closed a registered direct offering (the “Offering”) for the sale of 7,812,544 shares of common stock
at a purchase price of $0.80 per share for gross proceeds of $6.3 million (net proceeds of $5.6 million). The Purchase Agreement provides
that, subject to certain exceptions, until the earlier of (i) 90 days after the closing of the Offering or (ii) the trading day following
the date that our common stock’s closing price exceeds $2.00 for a period of 10 consecutive trading days, neither we nor our subsidiary
will issue or enter into any agreement to issue or announce the issuance or proposed issuance of any shares of common stock or common
stock equivalents.
We
paid the Placement Agent (“Spartan Capital” or “Spartan”) a cash fee of 8.0% of the gross proceeds from the Offering, excluding proceeds received from our insiders, and
reimbursed the Placement Agent for legal fees of $60,000. The engagement agreement with the Placement Agent requires us to indemnify
the Placement Agent and certain of its affiliates against certain customary liabilities. On February 14, 2023, we amended our consulting
agreement with Spartan originally entered into on August 24, 2022, extending the term of the consulting agreement until February 10,
2024. As compensation for services under the agreement, on April 17, 2023, we granted Spartan warrants to purchase 3,160,130 shares
of our common stock with an exercise price of $1.02. The warrants will expire three years from the date of issuance and contains both
call and cashless exercise provisions.
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- DefinitionThe entire disclosure for equity.
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v3.23.2
Stock-based Compensation
|
6 Months Ended |
Jun. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Stock-based Compensation |
Note
3 - Stock-based Compensation
On
June 19, 2019, our stockholders approved, and we adopted the Processa Pharmaceuticals Inc. 2019 Omnibus Equity Incentive Plan (the “2019
Plan”). The 2019 Plan allows us, under the direction of our Board of Directors or a committee thereof, to make grants of stock
options, restricted and unrestricted stock and other stock-based awards to employees, including our executive officers, consultants and
directors. The 2019 Plan provides for the aggregate issuance of 6,000,000 shares of our common stock. At June 30, 2023, we had 931,692
shares available for future grants.
Stock
Compensation Expense
We
recorded stock-based compensation expense for the three and six months ended June 30, 2023 and 2022 as follows:
Schedule
of Stock-based Compensation Expense
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Research and development | |
$ | 102,678 | | |
$ | 685,624 | | |
$ | 209,526 | | |
$ | 877,500 | |
General and administrative | |
| 216,445 | | |
| 1,323,745 | | |
| 451,101 | | |
| 1,960,766 | |
Total | |
$ | 319,123 | | |
$ | 2,009,369 | | |
$ | 660,627 | | |
$ | 2,838,266 | |
During
the six months ended June 30, 2023, we also recorded an expense of $1.3
million related to the warrants we issued to Spartan (see Note 2), which is not included in the table above. No tax benefits were attributed to
the stock-based compensation expense because a valuation allowance was maintained for all net deferred tax assets relating to this
expense.
Stock
Options
During
the six months ended June 30, 2023, stock options to purchase 36,885 shares of common stock expired and there were no exercises or grants
of stock options. At June 30, 2023, we had outstanding and exercisable options for the purchase of 141,611 shares with a weighted average
exercise price of $18.22, a weighted average remaining contractual life of 2.6
years. At June 30, 2023, we did not have any unrecognized stock-based compensation expense
related to our granted stock options.
Restricted
Stock Awards
Activity
with respect to our Restricted Stock Awards (RSAs) during the six months ended June 30, 2023 was as follows:
Schedule
of Restricted Stock Awards (“RSAs”) Activity
| |
Number of shares | | |
Weighted- average grant-date fair value per share | |
Outstanding at January 1, 2023 | |
| 61,888 | | |
$ | 4.72 | |
Granted | |
| 90,000 | | |
| 1.10 | |
Cancelled | |
| (26,118 | ) | |
| 1.72 | |
Issued | |
| (100,770 | ) | |
| 1.79 | |
| |
| | | |
| | |
Outstanding and unvested at June 30, 2023 | |
| 25,000 | | |
$ | 6.65 | |
On
January 1, 2023, we granted RSAs totaling 90,000 shares of common stock to three directors for their service for the six-month period
ending June 30, 2023 in order to align their compensation plan with their service period and change the annual service period to begin
and end on the date of respective Annual Meetings rather than the calendar year. Our directors are compensated through a combination
of cash and equity. On March 8, 2023, the directors increased the cash component and decreased the equity component of their compensation
by equal amounts on a retroactive basis, to the beginning of their respective service periods. Accordingly, we cancelled RSAs representing
26,118 shares of common stock.
At
June 30, 2023, the total unrecognized stock-based compensation expense related to the outstanding and unvested RSAs was $94,000,
which is expected to be recognized over a weighted average period of 1.3
years. The weighted-average grant-date fair value of RSAs granted during the six
months ended June 30, 2022 was $4.21.
Restricted
Stock Units
Activity
with respect to our Restricted Stock Units (“RSUs”) during the six months ended June 30, 2023 was as follows:
Schedule
of Restricted Stock Units (“RSUs”) Activity
| |
Number of shares | | |
Weighted- average grant-date fair value per share | |
Outstanding at January 1, 2023 | |
| 2,713,977 | | |
$ | 3.69 | |
Granted | |
| 1,473,328 | | |
| 0.90 | |
Cancelled | |
| (44,395 | ) | |
| 1.63 | |
Outstanding at June 30, 2023 | |
| 4,142,910 | | |
| 2.72 | |
Vested and unissued | |
| 2,590,497 | | |
| 3.51 | |
| |
| | | |
| | |
Unvested at June 30, 2023 | |
| 1,552,413 | | |
$ | 1.41 | |
At
June 30, 2023, unrecognized stock-based compensation expense of $1.2 million for RSUs is expected to be fully recognized over a weighted
average period of 1.5 years. The unrecognized expense excludes $322,000 of expense related to certain RSUs with a performance milestone
that is not probable of occurring at this time. The weighted-average grant-date fair value of RSUs granted during the six months ended June 30, 2022 was $3.01.
Holders
of our vested RSUs have our promise to issue shares of our common stock upon meeting the distribution restrictions contained in their
Restricted Stock Unit Award Agreement. The distribution restrictions are different (longer) than the vesting schedule, imposing an additional
restriction on the holder. Unlike RSAs, while certain employees may hold fully vested RSUs, the individual does not hold any shares or
have any rights of a shareholder until the distribution restrictions are met. Upon distribution to the employee, each RSU converts into
one share of our common stock. The RSUs contain dividend equivalent rights.
Warrants
During
the six months ended June 30, 2023, we granted warrants to purchase a total of 3,160,130 shares
of our common stock as compensation for services provided under an amended consulting agreement with Spartan Capital, the placement
agent for the Offering. The warrants were issued and
exercisable on April 17, 2023 with an exercise price of $1.02 and
expiration date of April 17, 2026. The warrants contains both call and cashless exercise provisions. We recorded $1,310,875 as
a general and administrative expense representing the fair value of these warrants on February 14, 2023, the date we amended the
consulting agreement since there were no contingent conditions on that date through April 17, 2023, the date of issuance. At
June 30, 2023, we had outstanding and exercisable stock purchase warrants for the purchase of 3,366,480 shares
with a weighted average exercise price of $1.61 and
a weighted average remaining contractual life of 2.5 years.
At
June 30, 2023, we did not have any unrecognized stock-based compensation expense related to our granted stock purchase warrants.
|
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- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.23.2
Net Loss per Share of Common Stock
|
6 Months Ended |
Jun. 30, 2023 |
Earnings Per Share [Abstract] |
|
Net Loss per Share of Common Stock |
Note
4 – Net Loss per Share of Common Stock
Net
Loss Per Share
Basic
net loss per share is computed by dividing our net loss available to common shareholders by the weighted average number of shares of
common stock outstanding (which excludes unvested RSAs and includes vested RSUs) during the period. Diluted loss per share is
computed by dividing our net loss available to common shareholders by the diluted weighted average number of shares of common stock
(which includes the potentially dilutive effect of stock options, unvested RSAs, unvested RSUs and warrants) during the period.
Since we experienced a net loss for both periods presented, basic and diluted net loss per share are the same. As such, diluted loss
per share for the three and six months ended June 30, 2023 and 2022 excludes the impact of potentially dilutive common shares since
those shares would have an anti-dilutive effect on net loss per share.
The
computation of net loss per share for the three- and six-month periods ended June 30, 2023 and 2022 was as follows:
Schedule
of Net Loss Per Share Basic and Diluted
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Basic and diluted net loss per share: | |
| | | |
| | | |
| | | |
| | |
Net loss available to common stockholders | |
$ | (2,612,565 | ) | |
$ | (5,164,368 | ) | |
$ | (6,634,638 | ) | |
$ | (8,391,499 | ) |
Weighted average number of common shares-basic and diluted | |
| 26,935,463 | | |
| 15,940,510 | | |
| 24,864,630 | | |
| 15,886,116 | |
| |
| | | |
| | | |
| | | |
| | |
Basic and diluted net loss per share | |
$ | (0.10 | ) | |
$ | (0.32 | ) | |
$ | (0.27 | ) | |
$ | (0.53 | ) |
Our
diluted net loss per share for the three and six months ended June 30, 2023 and 2022 excluded 5,085,504 and 1,965,502 of potentially
dilutive common shares, respectively, related to outstanding stock options, warrants and unvested restricted stock since those shares
would have had an anti-dilutive effect on net loss per share during the periods then ended.
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v3.23.2
Operating Leases
|
6 Months Ended |
Jun. 30, 2023 |
Operating Leases |
|
Operating Leases |
Note
5 – Operating Leases
We
lease our office space under an operating lease agreement. This lease does not have significant rent escalation, concessions, leasehold
improvement incentives, or other build-out clauses. Further, the lease does not contain contingent rent provisions. Our office space
lease includes both lease (e.g., fixed payments including rent, taxes, and insurance costs) and non-lease components (e.g., common-area
or other maintenance costs), which are accounted for as a single lease component as we have elected the practical expedient to group
lease and non-lease components for all leases. We also lease office equipment under an operating lease. Our leases do not provide an
implicit rate and, as such, we have used our incremental borrowing rate of 8% to determine the present value of the lease payments
based on the information available at the lease commencement date.
Lease
costs included in our condensed consolidated statements of operations totaled $24,000
for both three-month periods ended June 30, 2023 and 2022 and $49,000
for both six-month periods ended June 30, 2023 and 2022. The weighted average remaining lease terms and discount rate for
our operating leases were as follows at June 30, 2023:
Schedule
of Weighted Average Remaining Lease Terms and Discount Rate for Operating Leases
Remaining lease term (years) for our facility lease | |
| 2.3 | |
Remaining lease term (years) for our equipment lease | |
| 0.8 | |
Weighted average remaining lease term (years) for our facility and equipment leases | |
| 2.2 | |
Weighted average discount rate for our facility and equipment leases | |
| 8.0 | % |
Annual
lease liabilities for all operating leases were as follows at June 30, 2023:
Schedule
of Annual Lease Liabilities for all Operating Leases
| |
| | |
2023 | |
$ | 47,354 | |
2024 | |
| 92,356 | |
2025 | |
| 70,040 | |
Total lease payments | |
| 209,750 | |
Less: Interest | |
| (18,533 | ) |
Present value of lease liabilities | |
| 191,217 | |
Less: current maturities | |
| (81,890 | ) |
Non-current lease liability | |
$ | 109,327 | |
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v3.23.2
Related Party Transactions
|
6 Months Ended |
Jun. 30, 2023 |
Related Party Transactions [Abstract] |
|
Related Party Transactions |
Note
6 – Related Party Transactions
CorLyst,
LLC (“CorLyst”) reimburses us for shared costs related to payroll, health insurance and rent based on actual costs
incurred, which are recognized as a reduction of our general and administrative operating expenses being reimbursed in our condensed
consolidated statement of operations. We recorded $34,000
and $32,000
of reimbursements during the three months ended June 30, 2023 and 2022, respectively, and $64,000
for both six-month periods ended June 30, 2023 and 2022. No
amounts were due from CorLyst at June 30, 2023 or 2022. Dr. David Young is the CEO of CorLyst, and CorLyst is a shareholder.
|
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- DefinitionThe entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.
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v3.23.2
Commitments and Contingencies
|
6 Months Ended |
Jun. 30, 2023 |
Commitments and Contingencies Disclosure [Abstract] |
|
Commitments and Contingencies |
Note
7 – Commitments and Contingencies
Purchase
Obligations
We
enter into contracts in the normal course of business with contract research organizations (CROs) and subcontractors to further develop
our products. The contracts are cancelable, with varying provisions regarding termination. If we terminated a cancelable contract with
a specific vendor, we would only be obligated for products or services that we received at the effective date of the termination and
any applicable cancellation fees. At June 30, 2023, we are contractually obligated to pay up to $2.4 million of future services under
the agreements with the CROs. Our actual contractual obligations will also vary depending on the progress and results of the remaining
clinical trials.
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- DefinitionThe entire disclosure for commitments and contingencies.
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v3.23.2
Subsequent Event
|
6 Months Ended |
Jun. 30, 2023 |
Subsequent Events [Abstract] |
|
Subsequent Event |
Note 8 – Subsequent
Event
On August
8, 2023, Mr. George Ng was appointed as our Chief Executive Officer and as a Board Director. Mr. Ng is a seasoned life sciences industry
executive with significant experience successfully leading small-cap public companies including through product development and fundraising
activities. In connection with his employment, Mr. Ng will be paid an annual base salary of $400,000 and will be eligible to receive bonus
compensation of up to $100,000 contingent on Mr. Ng. meeting certain performance milestones during 2023 and 2024. In addition, the Compensation
Committee awarded 800,000 restricted stock units (“RSUs”) to Mr. Ng. Vesting for 400,000 RSUs occurs ratably over a three-year
period. The remaining 400,000 RSUs will vest on the achievement of certain performance metrics, with the first 200,000 performance-based
RSUs vesting when gross proceeds of $10,000,000 is raised, and the second 200,000 performance-based RSUs vesting when additional gross
proceeds of $10,000,000 is raised. He will also be eligible for other benefits as described in the Employment Agreement.
Given his oncology and
drug development expertise, Dr. David Young will transition to be our President, Research and Development, concentrating his
fulltime effort to drug development of our NGC drugs. By mutual agreement, Mr. R. Michael Floyd resigned as Chief Operating Officer
of the Company, effective August 31, 2023.
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v3.23.2
Organization and Summary of Significant Accounting Policies (Policies)
|
6 Months Ended |
Jun. 30, 2023 |
Accounting Policies [Abstract] |
|
Organization |
Organization
We
are a clinical-stage biopharmaceutical company focused on incorporating our Regulatory Science Approach into the development of our Next
Generation Chemotherapy (NGC) drugs to improve the safety and efficacy of cancer treatment. Our NGC drugs are modifications of existing
FDA-approved oncology drugs resulting in an alteration of the metabolism and/or distribution while maintaining the well-known and established
existing mechanisms of killing the cancer cells. By modifying the NGC drugs in this manner, we believe our three NGC treatments will
provide improved safety-efficacy profiles when compared to their currently marketed counterparts.
|
Basis of Presentation |
Basis
of Presentation
The
accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally
accepted in the United States of America (“U.S. GAAP”) for interim financial information and with the instructions of the
Securities and Exchange Commission (“SEC”) on Form 10-Q and Article 8 of Regulation S-X.
Accordingly,
they do not include all the information and disclosures required by U.S. GAAP for complete financial statements. All material intercompany
accounts and transactions have been eliminated in consolidation. In the opinion of management, the accompanying unaudited condensed consolidated
financial statements include all adjustments necessary, which are of a normal and recurring nature, for the fair presentation of our
financial position and of the results of operations and cash flows for the periods presented. These condensed consolidated financial
statements should be read in conjunction with the audited financial statements and notes thereto included in our Annual Report on Form
10-K for the year ended December 31, 2022, as filed with the SEC. The results of operations for the interim periods shown in this report
are not necessarily indicative of the results that may be expected for any other interim period or for the full year.
|
Going Concern and Management’s Plans |
Going
Concern and Management’s Plans
We
have incurred losses since inception, devoting substantially all of our efforts toward research and development, and have an accumulated
deficit of $70.9 million at June 30, 2023. During the six months ended June 30, 2023, we generated a net loss of $6.6 million and used
$4.2 million in net cash from operating activities from continuing operations. We expect to continue to generate operating losses and
negative cash flow from operations for the foreseeable future.
During
the six months ended June 30, 2023, we raised gross proceeds of $7.0 million (net proceeds of $6.4 million) from the sale of 8,432,192
shares of our common stock, as described in Note 2. We plan to use the net proceeds from these financings to prepare for future clinical
trials; and on research and development expenses, working capital and other general corporate purposes.
Our
condensed consolidated financial statements have been prepared using U.S. GAAP and are based on the assumption that we will continue
as a going concern, which contemplates the realization of assets and liquidation of liabilities in the normal course of business. We
face certain risks and uncertainties that are present in many emerging pharmaceutical companies regarding product development,
limited working capital, recurring losses and negative cash flow from operations, future profitability, ability to obtain future capital,
protection of patents, technologies and property rights, competition, rapid technological change, navigating the domestic and major foreign
markets’ regulatory and clinical environment, recruiting and retaining key personnel, dependence on third party manufacturing organizations,
third party collaboration and licensing agreements, lack of sales and marketing activities. We currently have no customers or pharmaceutical
products to sell or distribute. These risks and other factors raise substantial doubt about our ability to continue as a going concern.
At
June 30, 2023, we had cash and cash equivalents totaling $8.7
million. Based on our current plans, we believe our current cash balances will enable us to complete our current clinical trial in
NGC-Capecitabine (also known as PCS6422), prepare for future clinical trials, fund our administrative costs through the second
quarter of 2024, and close out the PCS499 and PCS12852 trials. Our ability to execute our longer-term operating plans, including
future clinical trials for our NGC drugs, will depend on our ability to obtain additional funding from the
sale of equity and/or debt securities, a strategic transaction or other funding transactions. We plan to continue to actively pursue
financing alternatives, including out-licensing and/or entering into partnerships on any of our non-core assets, but there can be no
assurance that we will obtain the necessary funding in the future when necessary.
We
had no revenue during the six months ended June 30, 2023 and do not have any revenue under contract or any immediate sales prospects.
Our primary uses of cash are to fund our planned clinical trials, research and development expenditures and other operating expenses.
Cash used to fund operating expenses is impacted by the timing of when we incur and pay these expenses.
We
are hoping to raise additional funds in 2023, but will only do so if terms are acceptable to us. Additional funding may not be
available to us on acceptable terms, or at all. If we are unable to obtain adequate financing when needed, we may have to delay,
reduce the scope of, or suspend our current or planned future clinical trial plans, or research and development programs. We may
seek to raise any necessary additional capital through a combination of public or private equity offerings, debt financings,
collaborations, strategic alliances, licensing arrangements and other marketing and distribution arrangements. To the extent that we
raise additional capital through marketing and distribution arrangements or other collaborations, strategic alliances or licensing
arrangements with third parties, we may have to relinquish valuable rights to our product candidates, future revenue streams,
research programs or product candidates or to grant licenses on terms that may not be favorable to us. If we raise additional
capital through public or private equity offerings, the ownership interest of our existing stockholders will be diluted, and the
terms of these securities may include liquidation or other preferences that adversely affect our stockholders’ rights. If we
raise additional capital through debt financing, we may be subject to covenants limiting or restricting our ability to take specific
actions, such as incurring additional debt, making capital expenditures or declaring dividends.
Uncertainty
concerning our ability to continue as a going concern may hinder our ability to obtain future financing. Continued operations and our
ability to continue as a going concern are dependent on our ability to obtain additional funding in the future and thereafter, and no
assurances can be given that such funding will be available at all, in a sufficient amount, or on reasonable terms. Without additional
funds from debt or equity financing, sales of assets, sales or out-licenses of intellectual property or technologies, or other transactions
providing funds, we will rapidly exhaust our resources and be unable to continue operations. Absent additional funding, we believe that
our cash and cash equivalents will not be sufficient to fund our operations for a period of one year or more after the date that these
condensed consolidated financial statements are available to be issued based on the timing and amount of our projected net loss from
continuing operations and cash to be used in operating activities during that period of time.
As
a result, substantial doubt exists about our ability to continue as a going concern within one year after the date that these condensed
consolidated financial statements are available to be issued. The accompanying condensed consolidated financial statements do not include
any adjustments to reflect the possible future effects on the recoverability and classification of recorded assets, or the amounts and
classification of liabilities that might be different should we be unable to continue as a going concern based on the outcome of these
uncertainties described above.
|
Use of Estimates |
Use
of Estimates
In
preparing our condensed consolidated financial statements and related disclosures in conformity with U.S. GAAP and pursuant to the rules
and regulations of the SEC, we make estimates and judgments that affect the amounts reported in the condensed consolidated financial
statements and accompanying notes. Estimates are used for, but not limited to preclinical and clinical trial expenses, stock-based compensation,
intangible assets, future milestone payments and income taxes. These estimates and assumptions are continuously evaluated and are based
on management’s experience and knowledge of the relevant facts and circumstances. While we believe the estimates to be reasonable,
actual results could differ materially from those estimates and could impact future results of operations and cash flows.
|
Income Taxes |
Income
Taxes
We
account for income taxes in accordance with ASC Topic 740, Income Taxes. Deferred income taxes are recorded for the expected tax
consequences of temporary differences between the basis of assets and liabilities for financial reporting purposes and amounts recognized
for income tax purposes. At June 30, 2023 and December 31, 2022, we recorded a valuation allowance equal to the full recorded amount
of our net deferred tax assets since it is more-likely-than-not that such benefits will not be realized. The valuation allowance is reviewed
quarterly and is maintained until sufficient positive evidence exists to support its reversal.
Under
ACS 740-270 Income Taxes – Interim Reporting, we are required to project our annual federal and state effective income tax
rate and apply it to the year-to-date ordinary operating tax basis loss before income taxes. Based on the projection, no current income
tax benefit or expense is expected for 2023 and the foreseeable future since we expect to generate taxable net operating losses.
|
Concentration of Credit Risk |
Concentration
of Credit Risk
Financial
instruments that potentially subject us to significant concentration of credit risk consist primarily of our cash and cash equivalents.
We utilize only well-established banks and financial institutions with high credit ratings. Balances on deposit are insured by the Federal
Deposit Insurance Corporation (FDIC) up to specified limits. Total cash held by our banks at June 30, 2023, exceeded FDIC limits.
|
Recent Accounting Pronouncements |
Recent
Accounting Pronouncements
From
time to time, the Financial Accounting Standards Board (“FASB”) or other standard setting bodies issue new accounting pronouncements.
Updates to the FASB Accounting Standards Codification are communicated through issuance of an Accounting Standards Update (“ASU”).
We have implemented all new accounting pronouncements that are in effect and that may impact our condensed consolidated financial statements.
We have evaluated recently issued accounting pronouncements and determined that there is no material impact on our consolidated financial
position or results of operations.
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v3.23.2
Stock-based Compensation (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Schedule of Stock-based Compensation Expense |
We
recorded stock-based compensation expense for the three and six months ended June 30, 2023 and 2022 as follows:
Schedule
of Stock-based Compensation Expense
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Research and development | |
$ | 102,678 | | |
$ | 685,624 | | |
$ | 209,526 | | |
$ | 877,500 | |
General and administrative | |
| 216,445 | | |
| 1,323,745 | | |
| 451,101 | | |
| 1,960,766 | |
Total | |
$ | 319,123 | | |
$ | 2,009,369 | | |
$ | 660,627 | | |
$ | 2,838,266 | |
|
Schedule of Restricted Stock Awards (“RSAs”) Activity |
Activity
with respect to our Restricted Stock Awards (RSAs) during the six months ended June 30, 2023 was as follows:
Schedule
of Restricted Stock Awards (“RSAs”) Activity
| |
Number of shares | | |
Weighted- average grant-date fair value per share | |
Outstanding at January 1, 2023 | |
| 61,888 | | |
$ | 4.72 | |
Granted | |
| 90,000 | | |
| 1.10 | |
Cancelled | |
| (26,118 | ) | |
| 1.72 | |
Issued | |
| (100,770 | ) | |
| 1.79 | |
| |
| | | |
| | |
Outstanding and unvested at June 30, 2023 | |
| 25,000 | | |
$ | 6.65 | |
|
Schedule of Restricted Stock Units (“RSUs”) Activity |
Activity
with respect to our Restricted Stock Units (“RSUs”) during the six months ended June 30, 2023 was as follows:
Schedule
of Restricted Stock Units (“RSUs”) Activity
| |
Number of shares | | |
Weighted- average grant-date fair value per share | |
Outstanding at January 1, 2023 | |
| 2,713,977 | | |
$ | 3.69 | |
Granted | |
| 1,473,328 | | |
| 0.90 | |
Cancelled | |
| (44,395 | ) | |
| 1.63 | |
Outstanding at June 30, 2023 | |
| 4,142,910 | | |
| 2.72 | |
Vested and unissued | |
| 2,590,497 | | |
| 3.51 | |
| |
| | | |
| | |
Unvested at June 30, 2023 | |
| 1,552,413 | | |
$ | 1.41 | |
|
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v3.23.2
Net Loss per Share of Common Stock (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Earnings Per Share [Abstract] |
|
Schedule of Net Loss Per Share Basic and Diluted |
The
computation of net loss per share for the three- and six-month periods ended June 30, 2023 and 2022 was as follows:
Schedule
of Net Loss Per Share Basic and Diluted
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Basic and diluted net loss per share: | |
| | | |
| | | |
| | | |
| | |
Net loss available to common stockholders | |
$ | (2,612,565 | ) | |
$ | (5,164,368 | ) | |
$ | (6,634,638 | ) | |
$ | (8,391,499 | ) |
Weighted average number of common shares-basic and diluted | |
| 26,935,463 | | |
| 15,940,510 | | |
| 24,864,630 | | |
| 15,886,116 | |
| |
| | | |
| | | |
| | | |
| | |
Basic and diluted net loss per share | |
$ | (0.10 | ) | |
$ | (0.32 | ) | |
$ | (0.27 | ) | |
$ | (0.53 | ) |
|
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v3.23.2
Operating Leases (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Operating Leases |
|
Schedule of Weighted Average Remaining Lease Terms and Discount Rate for Operating Leases |
Schedule
of Weighted Average Remaining Lease Terms and Discount Rate for Operating Leases
Remaining lease term (years) for our facility lease | |
| 2.3 | |
Remaining lease term (years) for our equipment lease | |
| 0.8 | |
Weighted average remaining lease term (years) for our facility and equipment leases | |
| 2.2 | |
Weighted average discount rate for our facility and equipment leases | |
| 8.0 | % |
|
Schedule of Annual Lease Liabilities for all Operating Leases |
Annual
lease liabilities for all operating leases were as follows at June 30, 2023:
Schedule
of Annual Lease Liabilities for all Operating Leases
| |
| | |
2023 | |
$ | 47,354 | |
2024 | |
| 92,356 | |
2025 | |
| 70,040 | |
Total lease payments | |
| 209,750 | |
Less: Interest | |
| (18,533 | ) |
Present value of lease liabilities | |
| 191,217 | |
Less: current maturities | |
| (81,890 | ) |
Non-current lease liability | |
$ | 109,327 | |
|
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v3.23.2
Organization and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
|
3 Months Ended |
6 Months Ended |
|
Jun. 30, 2023 |
Mar. 31, 2023 |
Jun. 30, 2022 |
Mar. 31, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Dec. 31, 2022 |
Accounting Policies [Abstract] |
|
|
|
|
|
|
|
Accumulated deficit |
$ 70,882,199
|
|
|
|
$ 70,882,199
|
|
$ 64,247,561
|
Net loss |
2,612,565
|
$ 4,022,073
|
$ 5,164,368
|
$ 3,227,131
|
6,634,638
|
$ 8,391,499
|
|
Net cash provided by operating activities |
|
|
|
|
4,178,539
|
4,133,439
|
|
Proceeds from sale of common stock |
|
|
|
|
7,000,000.0
|
|
|
Net proceeds from sale of stock |
|
|
|
|
$ 6,352,077
|
|
|
Sale of common stock, shares |
|
|
|
|
8,432,192
|
|
|
Cash and cash equivalents |
$ 8,677,133
|
|
|
|
$ 8,677,133
|
|
$ 6,503,595
|
Revenue |
|
|
|
|
$ 0
|
|
|
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v3.23.2
Stockholders’ Equity (Details Narrative) - USD ($)
|
|
|
|
3 Months Ended |
6 Months Ended |
|
|
|
|
Feb. 14, 2023 |
Mar. 23, 2022 |
Aug. 20, 2021 |
Mar. 31, 2023 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 27, 2023 |
Jun. 26, 2023 |
Apr. 17, 2023 |
Dec. 31, 2022 |
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Preferred stock, shares issued |
|
|
|
|
0
|
|
|
|
|
0
|
Preferred stock, shares outstanding |
|
|
|
|
0
|
|
|
|
|
0
|
Authorized shares of common stock |
|
|
|
|
100,000,000
|
|
100,000,000
|
50,000,000
|
|
100,000,000
|
Net proceeds from common stock |
|
|
|
|
$ 6,352,077
|
|
|
|
|
|
Sales Agreement [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Number of shares issued |
|
|
|
|
569,648
|
|
|
|
|
|
Shares issue price per share |
|
|
|
|
$ 1.22
|
|
|
|
|
|
Gross proceeds from common stock |
|
|
|
|
$ 693,000
|
|
|
|
|
|
Net proceeds from common stock |
|
|
|
|
$ 672,000
|
|
|
|
|
|
Sales Agreement [Member] | Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Maximum value to be sold at the market offering |
|
|
$ 30,000,000.0
|
|
|
|
|
|
|
|
Purchase Agreement [Member] | Lincoln Park Capital Fund LLC [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Number of shares issued |
|
|
|
|
50,000
|
|
|
|
|
|
Shares issue price per share |
|
|
|
|
$ 1.08
|
|
|
|
|
|
Net proceeds from common stock |
|
|
|
|
$ 54,000
|
|
|
|
|
|
Threshold price |
|
$ 1.00
|
|
|
|
|
|
|
|
|
Purchase Agreement [Member] | Maximum [Member] | Lincoln Park Capital Fund LLC [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Commitment to purchase common stock |
|
$ 15,000,000.0
|
|
|
|
|
|
|
|
|
Securities Purchase Agreement [Member] | Registered Direct Offering [Member] | Accredited Investor [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Number of shares issued |
7,812,544
|
|
|
|
|
|
|
|
|
|
Shares issue price per share |
$ 0.80
|
|
|
|
|
|
|
|
|
|
Gross proceeds from common stock |
$ 6,300,000
|
|
|
|
|
|
|
|
|
|
Net proceeds from common stock |
$ 5,600,000
|
|
|
|
|
|
|
|
|
|
Restrictions to issue stock |
The Purchase Agreement provides
that, subject to certain exceptions, until the earlier of (i) 90 days after the closing of the Offering or (ii) the trading day following
the date that our common stock’s closing price exceeds $2.00 for a period of 10 consecutive trading days, neither we nor our subsidiary
will issue or enter into any agreement to issue or announce the issuance or proposed issuance of any shares of common stock or common
stock equivalents.
|
|
|
|
|
|
|
|
|
|
Securities Purchase Agreement [Member] | Registered Direct Offering [Member] | Placement Agent [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Cash fee percentage |
8.00%
|
|
|
|
|
|
|
|
|
|
Reimbursement fees |
$ 60,000
|
|
|
|
|
|
|
|
|
|
Consulting Agreement [Member] | Spartan Capital Securites LLC [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Warrants to purchase common stock, shares |
|
|
|
|
|
|
|
|
3,160,130
|
|
Warrant exercise price |
|
|
|
|
|
|
|
|
$ 1.02
|
|
Warrant term |
|
|
|
|
|
|
|
|
3 years
|
|
Common Stock [Member] |
|
|
|
|
|
|
|
|
|
|
Class of Stock [Line Items] |
|
|
|
|
|
|
|
|
|
|
Number of shares issued |
|
|
|
8,432,192
|
8,432,192
|
|
|
|
|
|
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Schedule of Stock-based Compensation Expense (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Total |
$ 319,123
|
$ 2,009,369
|
$ 660,627
|
$ 2,838,266
|
Research and Development Expense [Member] |
|
|
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Total |
102,678
|
685,624
|
209,526
|
877,500
|
General and Administrative Expense [Member] |
|
|
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Total |
$ 216,445
|
$ 1,323,745
|
$ 451,101
|
$ 1,960,766
|
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Schedule of Restricted Stock Awards (“RSAs”) Activity (Details) - Restricted Stock [Member] - $ / shares
|
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
Number of restricted stock, shares outstanding |
61,888
|
|
Weighted-average grant-date fair value per share, outstanding |
$ 4.72
|
|
Number of shares, granted |
90,000
|
|
Weighted-average grant-date fair value per share, granted |
$ 1.10
|
$ 4.21
|
Number of shares, cancelled |
(26,118)
|
|
Weighted-average grant-date fair value per share, cancelled |
$ 1.72
|
|
Number of shares, vested and issued |
(100,770)
|
|
Weighted-average grant-date fair value per share, vested and issued |
$ 1.79
|
|
Number of restricted stock shares outstanding |
25,000
|
|
Weighted-average grant-date fair value per share, outstanding |
$ 6.65
|
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v3.23.2
Schedule of Restricted Stock Units (“RSUs”) Activity (Details) - Restricted Stock Units (RSUs) [Member] - $ / shares
|
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
Number of shares, Beginning balance |
2,713,977
|
|
Weighted-average grant-date fair value per share, Beginning balance |
$ 3.69
|
|
Number of shares, granted |
1,473,328
|
|
Weighted-average grant-date fair value per share, awarded |
$ 0.90
|
$ 3.01
|
Number of shares, cancelled |
(44,395)
|
|
Weighted-average grant-date fair value per share, cancelled |
$ 1.63
|
|
Number of shares, Ending balance |
4,142,910
|
|
Weighted-average grant-date fair value per share, Ending balance |
$ 2.72
|
|
Number of shares, vested and unissued |
2,590,497
|
|
Weighted-average grant-date fair value per share, vested and unissued |
$ 3.51
|
|
Number of restricted stock shares outstanding |
1,552,413
|
|
Weighted-average grant-date fair value per share, outstanding |
$ 1.41
|
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v3.23.2
Stock-based Compensation (Details Narrative) - USD ($)
|
|
|
3 Months Ended |
6 Months Ended |
Feb. 14, 2023 |
Jan. 01, 2023 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Warrants issued in connection with consulting agreement |
|
|
$ 1,310,875
|
|
|
|
General and Administrative Expense |
|
|
$ 1,026,301
|
$ 2,034,456
|
$ 3,477,490
|
$ 3,218,550
|
Warrant [Member] |
|
|
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Warrants issued in connection with consulting agreement |
|
|
|
|
$ 1,300,000
|
|
Weighted average exercise price |
$ 1.02
|
|
$ 1.61
|
|
$ 1.61
|
|
Warrants to purchase shares |
|
|
3,366,480
|
|
3,366,480
|
|
Weighted average remaining contractual life |
|
|
|
|
2 years 6 months
|
|
Warrant [Member] | Consultant [Member] |
|
|
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Warrants granted |
|
|
|
|
3,160,130
|
|
General and Administrative Expense |
$ 1,310,875
|
|
|
|
|
|
Share-Based Payment Arrangement, Option [Member] |
|
|
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Options, forfeited |
|
|
|
|
36,885
|
|
Options exercisable, shares |
|
|
141,611
|
|
141,611
|
|
Options exercisable weighted average exercise price |
|
|
$ 18.22
|
|
$ 18.22
|
|
Exercisable weighted average remaining contractual term |
|
|
|
|
2 years 7 months 6 days
|
|
Restricted Stock [Member] |
|
|
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Number of shares, granted |
|
|
|
|
90,000
|
|
Number of shares, cancelled |
|
|
|
|
26,118
|
|
Unrecognized share based compensation expense |
|
|
$ 94,000
|
|
$ 94,000
|
|
Weighted average period for recognition |
|
|
|
|
1 year 3 months 18 days
|
|
Weighted-average grant-date fair value per share |
|
|
|
|
$ 1.10
|
$ 4.21
|
Restricted Stock [Member] | Three Directors [Member] |
|
|
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Number of shares, granted |
|
90,000
|
|
|
|
|
Restricted Stock Units (RSUs) [Member] |
|
|
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Number of shares, granted |
|
|
|
|
1,473,328
|
|
Number of shares, cancelled |
|
|
|
|
44,395
|
|
Unrecognized share based compensation expense |
|
|
$ 1,200,000
|
|
$ 1,200,000
|
|
Weighted average period for recognition |
|
|
|
|
1 year 6 months
|
|
Weighted-average grant-date fair value per share |
|
|
|
|
$ 0.90
|
$ 3.01
|
Unrecognized restricted stock expense |
|
|
|
|
$ 322,000
|
|
2019 Plan [Member] |
|
|
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
|
|
Maximum equity available for issuance |
|
|
6,000,000
|
|
6,000,000
|
|
Shares available for future grants |
|
|
931,692
|
|
931,692
|
|
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v3.23.2
Schedule of Net Loss Per Share Basic and Diluted (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Mar. 31, 2023 |
Jun. 30, 2022 |
Mar. 31, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Earnings Per Share [Abstract] |
|
|
|
|
|
|
Net loss available to common stockholders |
$ (2,612,565)
|
$ (4,022,073)
|
$ (5,164,368)
|
$ (3,227,131)
|
$ (6,634,638)
|
$ (8,391,499)
|
Weighted average number of common shares-basic |
26,935,463
|
|
15,940,510
|
|
24,864,630
|
15,886,116
|
Weighted average number of common shares-diluted |
26,935,463
|
|
15,940,510
|
|
24,864,630
|
15,886,116
|
Basic net loss per share |
$ (0.10)
|
|
$ (0.32)
|
|
$ (0.27)
|
$ (0.53)
|
Diluted net loss per share |
$ (0.10)
|
|
$ (0.32)
|
|
$ (0.27)
|
$ (0.53)
|
X |
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v3.23.2
Net Loss per Share of Common Stock (Details Narrative) - shares
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Earnings Per Share [Abstract] |
|
|
|
|
Antidilutive securities excluded from computation of earnings per share, amount |
5,085,504
|
1,965,502
|
5,085,504
|
1,965,502
|
X |
- DefinitionSecurities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.
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v3.23.2
Schedule of Annual Lease Liabilities for all Operating Leases (Details) - USD ($)
|
Jun. 30, 2023 |
Dec. 31, 2022 |
Operating Leases |
|
|
2023 |
$ 47,354
|
|
2024 |
92,356
|
|
2025 |
70,040
|
|
Total lease payments |
209,750
|
|
Less: Interest |
(18,533)
|
|
Present value of lease liabilities |
191,217
|
|
Less: current maturities |
(81,890)
|
$ (78,896)
|
Non-current lease liability |
$ 109,327
|
$ 150,554
|
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v3.23.2
Subsequent Event (Details Narrative) - USD ($)
|
|
6 Months Ended |
Aug. 08, 2023 |
Jun. 30, 2023 |
Restricted Stock Units (RSUs) [Member] |
|
|
Subsequent Event [Line Items] |
|
|
Number of shares, granted |
|
1,473,328
|
Subsequent Event [Member] |
|
|
Subsequent Event [Line Items] |
|
|
Annual base salary |
$ 400,000
|
|
Bonus compensation |
$ 100,000
|
|
Subsequent Event [Member] | Restricted Stock Units (RSUs) [Member] |
|
|
Subsequent Event [Line Items] |
|
|
Number of shares, granted |
800,000
|
|
Subsequent Event [Member] | Service Based RSU [Member] |
|
|
Subsequent Event [Line Items] |
|
|
Number of shares, granted |
400,000
|
|
Subsequent Event [Member] | First Performance Based R S U [Member] |
|
|
Subsequent Event [Line Items] |
|
|
Number of shares, granted |
200,000
|
|
Performance vesting criteria |
$ 10,000,000
|
|
Subsequent Event [Member] | Second Performance Based R S U [Member] |
|
|
Subsequent Event [Line Items] |
|
|
Number of shares, granted |
200,000
|
|
Performance vesting criteria |
$ 10,000,000
|
|
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